A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.
A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).
Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.
An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)
A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
Phenolic benzoic acid esters.
A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.
A plant species of the genus IPOMOEA, family CONVOLVULACEAE. Some cultivars are sweet and edible whereas bitter varieties are a source of SAPONINS. This sweet potato is sometimes referred to as a yam (DIOSCOREA).
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A large class of organic compounds having more than one PHENOL group.
A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.
A genus of perennial herbs used topically and internally. It contains echinacoside, GLYCOSIDES; INULIN; isobutyl amides, resin, and SESQUITERPENES.
A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A plant genus of the family ASTERACEAE. Ingestion has been associated with MILK SICKNESS. The common name of thoroughwort is also used for other plants including CHROMOLAENA; Hebeclinium, and Koanophyllon.
A plant species of the Salvia genus known as a spice and medicinal plant.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Dioxygenases that catalyze the peroxidation of methylene-interrupted UNSATURATED FATTY ACIDS.
Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.

Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (1/401)

The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. Substrates containing a -COOH group are inhibitors for catechol oxidase. The products of enzymic oxidation of caffeic acid were analyzed and isolated by HPLC with diode array detection. The neolignans of the 2,3-dihydro-1,4-benzodioxin type (3, 6-8), 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-2,3-dicarboxy-1,2-dihydro naphthaline (1) 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-3-carboxynaphthaline (5) and 2,6-bis-(3',4'-dihydroxyphenyl)-1-carboxy-3-oxacyclo-(3,0)-pent an-2-on-1-ene (4) were formed. A reaction mechanism for the formation of (1, 4 and 5) is discussed.  (+info)

Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase. (2/401)

In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and dopa decarboxylase and showed hypotensive activity in the SH rat.  (+info)

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. (3/401)

We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 microg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediated induction of PGE2 synthesis. This relatively low concentration of CAPE did not affect amounts of cyclooxygenase (COX) enzymes. CAPE nonselectively inhibited the activities of baculovirus-expressed hCOX-1 and hCOX-2 enzymes. TPA- and A23187-stimulated release of arachidonic acid from membrane phospholipids was also suppressed by CAPE (4-8 microg/ml). Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA. Transient transfections using human COX-2 promoter deletion constructs were performed; the effects of TPA and CAPE were localized to a 124-bp region of the COX-2 promoter. In the rat carrageenan air pouch model of inflammation, CAPE (10-100 mg/kg) caused dose-dependent suppression of PG synthesis. Amounts of COX-2 in the pouch were markedly suppressed by 100 mg/kg CAPE but were unaffected by indomethacin. These data are important for understanding the anticancer and anti-inflammatory properties of CAPE.  (+info)

Genetic analysis of a chromosomal region containing vanA and vanB, genes required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter. (4/401)

VanA and VanB form an oxygenative demethylase that converts vanillate to protocatechuate in microorganisms. Ferulate, an abundant phytochemical, had been shown to be metabolized through a vanillate intermediate in several Pseudomonas isolates, and biochemical evidence had indicated that vanillate also is an intermediate in ferulate catabolism by Acinetobacter. Genetic evidence supporting this conclusion was obtained by characterization of mutant Acinetobacter strains blocked in catabolism of both ferulate and vanillate. Cloned Acinetobacter vanA and vanB were shown to be members of a chromosomal segment remote from a supraoperonic cluster containing other genes required for completion of the catabolism of ferulate and its structural analogs, caffeate and coumarate, through protocatechuate. The nucleotide sequence of DNA containing vanA and vanB demonstrated the presence of genes that, on the basis of nucleotide sequence similarity, appeared to be associated with transport of aromatic compounds, metabolism of such compounds, or iron scavenging. Spontaneous deletion of 100 kb of DNA containing this segment does not impede the growth of cells with simple carbon sources other than vanillate or ferulate. Additional spontaneous mutations blocking vanA and vanB expression were shown to be mediated by IS1236, including insertion of the newly discovered composite transposon Tn5613. On the whole, vanA and vanB appear to be located within a nonessential genetic region that exhibits considerable genetic malleability in Acinetobacter. The overall organization of genes neighboring Acinetobacter vanA and vanB, including a putative transcriptional regulatory gene that is convergently transcribed and overlaps vanB, is conserved in Pseudomonas aeruginosa but has undergone radical rearrangement in other Pseudomonas species.  (+info)

The rabbit lens epithelial cell line N/N1003A requires 12-lipoxygenase activity for DNA synthesis in response to EGF. (5/401)

PURPOSE: Cultured rat lenses and primary human lens epithelial cells (HLECs) express12-lipoxygenase (12-LOX) and require a 12-LOX metabolite of arachidonic acid for growth in response to EGF and insulin. This study seeks to identify an established cell line with these characteristics. METHODS: Immunoblotting was used to screen eight lens epithelial cell lines for 12-LOX expression: the human line, HLE-B3; mouse lines alphaTN4, 17EM15, 21EM15, and MLE6, and rabbit lines N/N1003A, LEP2 and B3. DNA synthesis was measured as incorporation of 3H-thymidine into DNA. Expression of c-fos mRNA was detected by RT-PCR. The involvement of 12-lipoxygenase metabolites was determined using the lipoxygenase inhibitors baicalein, cinnamyl 3,4-dihydroxy-alpha-cyanocinnamate (CDC), or nordihydroguiairetic acid (NDGA). RESULTS: 12-LOX was detected only in the rabbit lines N/N1003A, LEP2 and B3. N/N1003A cells were chosen for further study. 12-LOX inhibitors blocked DNA synthesis in response to EGF with or without insulin. Inhibition of EGF-stimulated DNA synthesis was reversed by 0.3 microM to 3 microM 12(S)hydroxyeicosatetraenoic acid (HETE), but not by equivalent concentrations of 5(S)HETE, 8(S)HETE, 15(S)HETE, or 12(R)HETE. Baicalein prevented EGF induction of c-fos mRNA. The transformed HLEC line, HLE-B3, showed little stimulation of DNA synthesis in response to EGF and was unaffected by the presence of 12-LOX inhibitors. CONCLUSIONS: N/N1003A cells, like primary cultured human lens epithelial cells or neonatal rat lenses, require 12-LOX activity for EGF dependent growth. This line will be useful for studies of the mechanism of action of 12(S)HETE.  (+info)

An early salicylic acid-, pathogen- and elicitor-inducible tobacco glucosyltransferase: role in compartmentalization of phenolics and H2O2 metabolism. (6/401)

Treatment of tobacco cell suspension cultures with a fungal elicitor of defense responses resulted in an early accumulation of the phenylpropanoid glucosyltransferase TOGT, along with the rapid synthesis and secretion of scopolin, the glucoside of scopoletin. Elicitor-triggered extracellular accumulation of the aglycone scopoletin and of free caffeic and ferulic acids could only be revealed in the presence of diphenylene iodonium, an inhibitor of extracellular H2O2 production. Our results strongly support a role for TOGT in the elicitor-stimulated production of transportable phenylpropanoid glucosides, followed by the release of free antioxidant phenolics into the extracellular medium and subsequent H2O2 scavenging.  (+info)

The small intestine can both absorb and glucuronidate luminal flavonoids. (7/401)

We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.  (+info)

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. (8/401)

The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents. Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in cell proliferation and survival. In this study, we investigated the potential role of AA as a proapoptotic agent in CML. Pretreatment of human CML isolated progenitor cells with AA (100 microM for 18 h) induced 71-75% inhibition of in vitro colony formation of granulocyte-macrophage colony-forming units, multilineage colony-forming units, and erythroid burst-forming units. This inhibition was significantly greater than the effect on normal progenitor cells (19-39% growth inhibition of erythroid burst-forming units, multilineage colony-forming units, and granulocyte-macrophage colony-forming units). AA also inhibited growth of the bcr-abl-transformed cell line H7.bcr-abl A54. In contrast, a minimal effect of AA on inhibition of cell growth was observed in the parental nontransformed NSF/N1.H7 cell line. The antiproliferative effect of AA was associated with apoptosis. Gamma-linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no effect. Pharmacological inhibition of cyclooxygenase, lipooxygenase, and cytochrome P450 monooxygenase enzymes prior to exposure to AA did not rescue cells from the inhibitory effect of AA. Moreover, 5,8,11,14-eicosatetraynoic acid, a nonmetabolizable arachidonate analogue, also inhibited cell growth, suggesting that the effect of AA did not require further metabolism. Treatment with antioxidants prior to stimulation with AA was also ineffective in preventing its antiproliferative effect. Thus, AA inhibited proliferation of CML cells by inducing apoptotic cell death. The signaling mechanisms of AA-induced inhibition of cell growth appeared to be independent of its conversion into eicosanoids or free radical generation.  (+info)

Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol ring of caffeic acid esters in the presence of sodium benenesulfinate and sodium toluensulfinate as nucleophiles. Both heterocycle esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against HeLa, SK-OV-3, and HT-29 cancer cell lines. HeLa cells showed the highest sensitivity to the compounds and heterocyclic esters with no substituent on catechol ring showed better activity compared to their substituted counterparts. QSAR studies reemphasized the importance of molecular shape of the compounds for their cytotoxic activity.
AIM: Caffeic acid has been described as active against bacteria commonly isolated from wound infections. However, its low stability and poor solubility reduce caffeic acid applicability as a pharmaceutical product. These parameters can be enhanced by complexation with cyclodextrin. The main goal of the present work was to incorporate caffeic acid on cyclodextrin-based hydrogels capable of controlled delivery, in order to be used as antibacterial wound dressing. MATERIALS & METHODS: Cyclodextrin-based hydrogels were prepared by direct crosslinking of -cyclodextrin or hydroxypropyl--cyclodextrin with 1,4-butanediol diglycidyl ether in the presence of hydroxypropyl methylcellulose. RESULTS: The hydrogels obtained combine good physicochemical properties (viscoelasticity, superabsorbency and high ability to retain and deliver caffeic acid) with the preservation of caffeic acid antibacterial activity and effect on fibroblasts, with gel--cyclodextrin the most suited. CONCLUSION: The hydrogels obtained ...
Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke results from a temporary or permanent reduction of cerebral blood flow that leads to functional and structural damage in different brain regions. Despite decades of intense research, the beneficial treatment of stroke remains limited. In light of this, the search for effective means ameliorating cerebral ischemia-reperfusion injury (CIRI) is one of the major problems of experimental medicine and biology. Recently, the 5-Lipoxygenase (5-LO, a key enzyme metabolizing arachidonic acid to produce leukotrienes) inhibitors have been showed to protect brain against ischemic damage in animal model of cerebral ischemia. Caffeic acid, an inhibitor of 5-LO, is a phenolic compound widely distributed in medicinal plants. The aim of this study was to investigate the effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. The study was carried out on 45 rats that were randomly divided into five groups:
TY - JOUR. T1 - Letter to the Editor regarding Effects of caffeic acid on cisplatin-induced hair cell damage in HEI-OC1 auditory cells. AU - Kim, Shin Hye. AU - Choi, June. AU - Park, Moo Kyun. PY - 2016/2/1. Y1 - 2016/2/1. UR - http://www.scopus.com/inward/record.url?scp=84969724108&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84969724108&partnerID=8YFLogxK. U2 - 10.1016/j.ijporl.2015.12.010. DO - 10.1016/j.ijporl.2015.12.010. M3 - Letter. C2 - 26786961. AN - SCOPUS:84969724108. VL - 81. JO - International Journal of Pediatric Otorhinolaryngology. JF - International Journal of Pediatric Otorhinolaryngology. SN - 0165-5876. ER - ...
In tissue cultures, caffeic acid inhibits the development of human breast cancer cells, and of melanoma skin cancer cells. Many different studies have confirmed this response to caffeic acid. The medical journal, Cancer Research, has proposed that the caffeic acids in propolis could even help to prevent colon cancer, because in experiments, propolis stopped the formation of cancerous growths in rats which had been exposed to carcinogens. Much study continues to be done with caffeic acid and propolis ...
This paper describes experimentally verifiable computational chemistry results of the environmentally benign caffeic acid (CA) antioxidant. Computations at density functional level (DFT) and its time dependent (TD) extension are carried out to explain results obtained experimentally in our laboratories. Emphases are on acidity constants, photodegradation, fluorescence quenching by metal ligation, and UV-Vis absorption characteristics of CA. Additionally, quantitative structure activity indices and composite maps that visualizing nucleophilicity, electrophilicity, and potential energy surface (PES map) are computed and discussed.
In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-|i|κ|/i|B activation and reducing proinflammatory cytokine expression. While the underlying mechanism remains unclear, here, we determined that LPS induced the extensive microstructural damage of bMEC, especially the mitochondria and endoplasmic reticulum. Then, the obvious reduction of mitochondrial membrane potential and expression changes of apoptosis-associated proteins (Bcl-2, Bax, and casepase-3) indicated that apoptosis signaling through the mitochondria should be responsible for the cell viability decrease. Next, the high-throughput cDNA sequencing (RNA-Seq) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were employed to verify that the MAPK and JAK-STAT signaling pathways also were the principal targets of LPS. Following, the
Caffeic acid has a high antioxidant potential. Studies show higher exercise tolerance significant reduction of the blood glucose.
The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenicacid increase vitamin e and cholesterol concentrations in Sprague-Dawleyrats. ...
A number of factors, including diet, obesity, and exercise, affect the level of deoxycholate in the human colon. When humans were switched from their usual diet to a meat, egg and cheese based diet for five days, deoxycholate in their feces increased by factors of 2 to 10 fold.[34] Rats, fed diets with either 30% beef tallow (high fat) or 5% beef tallow (low fat) had almost 2-fold more deoxycholate in their feces on the high fat compared to the low fat diet.[35] In this study,[35] adding the further dietary elements of curcumin or caffeic acid to the rats high fat (30% beef tallow) diet reduced the deoxycholate in their feces to levels comparable to levels seen in the rats on a low fat diet. Curcumin is a component of the spice turmeric, and caffeic acid is a component high in some fruits and spices.[36] Caffeic acid is also a digestive break-down product of chlorogenic acid, high in coffee and some fruits and vegetables.[37] In addition to fats, the type or amount of protein in the diet may ...
Rapamycin (Sirolimus?) is used to avoid rejection of transplanted organs and coronary restenosis. had been treated with rapamycin (0.25 mg/kg i.p.) or automobile (DMSO) with/without inhibitor of JAK2 (AG-490) or STAT3 (stattic). 1 hour later on the hearts were put through I/R either in Langendorf ligation or mode oleft coronary artery. Caffeic acid Additionally major murine cardiomyocytes had been put through simulated ischemia/reoxygenation (SI-RO) damage targeted knockdown of STAT3 lentiviral vector formulated with brief hairpin RNA was injected into still left ventricle 3 weeks ahead of initiating I/R damage. Infarct size cardiac function cardiomyocyte apoptosis Caffeic acid and necrosis were assessed. Rapamycin decreased infarct size improved cardiac function pursuing I/R limited cardiomyocytes necrosis aswell as apoptosis Caffeic acid pursuing SI-RO that have been obstructed by AG-490 and stattic. In situ knock-down of STAT3 attenuated rapamycin-induced security against I/R damage. ...
The amount of dietary trace elements absorbed from a meal depends, among other factors, on the quantities of certain minor plant constituents present in the meal. These substances can act as ligands and bind trace elements in the digestive tract in a
ABSTRACTPhenolic acids have been associated to a wide range of important health benefits underlain by a common molecular mechanism of action. Considering that significant membrane permeation is prevented by their hydrophilic character, we hypothesize that their main effects result from the interplay
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The protective effect of caffeic acid on ferric-induced pancreatic injury was investigated using ex vivo and in silico models. Incubation of pancreatic tissues with Fe2+led to significant depleted...
Flavonoid glycosides and caffeic acid derivatives are widely distributed in the plant kingdom. Many crops owe their red or blue color to the presence of anthocyanins. Their hue depends on their structure, pH and presence of chelating metal ions. Obviously, they are important for visual plant quality. Furthermore, polyphenolic compounds like flavonoids and phenolic acids are reported to have beneficial effects on our health by providing high antioxidant and radical scavenging activity. Yet, studies on health promoting effects are discussed controversially. Results differ between in vitro and in vivo experiments which were conducted with single or several substances or plant extracts. Some of these differences are probably due to varying bioavailability, synergisms between substances and matrix effects. In plants, foliar flavonoids can serve as photoprotectants and shield the photosystem from excess energy and UV radiation. Additionally, they play important roles in the plants interaction with ...
Propolis works as a powerful anti-inflammatory, thanks to the content of caffeic acid and flavonoids, very useful in case of asthma. It helps prevent colds, flu and seasonal ailments and it also strengthens the immune system. It also has antiviral, antifungal, healing and vasoprotective properties: it is also used in case of burns and pimples, because it helps to heal them. Propolis gives immediate relief in case of sore throat and it is also useful for treating abscesses, stomatitis and canker sores. It is also an effective remedy for gingivitis or aching teeth. It may also be useful to take propolis to relieve the symptoms of allergic rhinitis: this substance would work as a kind of natural vaccine. It is in fact a potentially allergenic product, as it contains pollen, but it is possible to accustom the body gradually under medical supervision. ...
Kudugunti, S. K., Vad, N. M., Whiteside, A. J., Naik, B. U., Yusuf, M. A., Srivenugopal, K. S., & Moridani, M. Y. (2010). Biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) selective toxicity towards melanoma cell lines. Chemico-Biological Int ...
Our present results establish for the first time that MTI-induced apoptosis and 15-LOX-1 expression are linked mechanistically in colorectal cancer cells. The demethylating agents 5-Azadc, 5-azacytidine, and zebularine can induce 15-LOX-1 expression, indicating that methylation may play a role in 15-LOX-1 regulation. 5-Azadc induced 15-LOX-1 expression in a dose- and time-dependent manner and induced growth arrest and apoptosis in Caco-2 colon cancer cells. Inhibiting 15-LOX-1 with caffeic acid (at the 2.2 μmol/L concentration shown to be specific for 15-LOX-1 inhibition) or siRNA attenuated 5-Azadc-induced growth inhibition and apoptosis, indicating a direct relationship between 15-LOX-1 and these biological effects. These findings identify a molecular mechanism by which MTIs induce apoptosis and other cellular effects and further elucidate the role of 15-LOX-1 in human colorectal carcinogenesis. Our findings are consistent with results of other studies, which showed a 15-LOX-1-apoptosis link ...
Moleculin Biotech (previously Moleculin), a spin-off company of the University of Texas M.D. Anderson Cancer Center, is developing caffeic acid analogues as
Fig. S1. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the indicated concentrations of CAPE (0-100 μM). The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells were measured by flow cytometry.. Fig. S2. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and anti-CD28 monoclonal antibodies (2 μg/ml) stimulation. The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells from four asthmatic patients were measured by flow cytometry.. Fig. S3. Caffeic acid phenethyl ester (CAPE) inhibits interferon (IFN)-γ and interleukin (IL)-5 production by polarized T helper type 1 (Th1) and Th2 cells. Polarized helper T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and ...
TY - JOUR. T1 - Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. AU - Lin, Hui Ping. AU - Lin, Ching Yu. AU - Huo, Chieh. AU - Hsiao, Ping Hsuan. AU - Su, Liang Cheng. AU - Jiang, Shih Sheng. AU - Chan, Tzu Min. AU - Chang, Chung Ho. AU - Chen, Li Tzong. AU - Kung, Hsing Jien. AU - Wang, Horng Dar. AU - Chuu, Chih Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells. We identified that CAPE treatment significantly reduced ...
TY - JOUR. T1 - Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. AU - Wang, L. C.. AU - Chu, K. H.. AU - Liang, Y. C.. AU - Lin, Y. L.. AU - Chiang, B. L.. PY - 2010/5. Y1 - 2010/5. N2 - Summary Caffeic acid phenethyl ester (CAPE), an active component in propolis, is known to have anti-tumour, anti-inflammatory and anti-oxidant properties. In this study, the effects of CAPE on the functions of primary human CD4+ T cells were evaluated in vitro. CAPE significantly suppressed interferon (IFN)-γ and interleukin (IL)-5 production and proliferation of CD4+ T cells stimulated by soluble anti-CD3 and anti-CD28 monoclonal antibodies in both healthy subjects and asthmatic patients. CAPE inhibited nuclear factor (NF)-κB activation and protein kinase B (Akt) phosphorylation, but not p38 mitogen-activated protein kinase (MAPK) phosphorylation in T cells. CAPE also induced active caspase-3 ...
BACKGROUND:Our aim was to study the effect of caffeic acid phenethyl ester (CAPE) on iNOS and cystathionine gamma-lyase (CSE) of hepatic fibrosis rat, and discuss the anti-hepatic fibrosis mechanism of caffeic acid phenethyl ester. MATERIAL AND METHODS:We observed changes of NO and H2S in serum of hepatic fibrosis rats. Enzyme-linked immunosorbent assay was used to test OD value of iNOS and CSE in serum of each. The expressions of iNOS and CSE protein in the liver were also detected by immunohistochemistry. RESULTS:Compared with the model group, the expression of NO and iNOS was decreased obviously and the level of H2S and CSE was increased in the CAPE group. CONCLUSIONS:CAPE has the effect of anti-hepatic fibrosis, which can be realized through adjusting the expression level of iNOS and CSE.
In vivo and in vitro antıneoplastic actions of caffeic acid phenethyl ester (CAPE): therapeutic perspectives.. Akyol S1, Ozturk G, Ginis Z, Armutcu F, Yigitoglu MR, Akyol O.. Author information. Abstract. Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-κB at μM concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.. PMID: 23659443 [PubMed - indexed for MEDLINE]. ...
We found that micromolar concentrations of caffeic acid phenethyl ester blocked voltage-gated sodium channel activity in several invasive cell lines from different cancers, including breast (MDA-MB-231 and MDA-MB-468), colon (SW620) and non-small cell lung cancer (H460). In the MDA-MB-231 cell line, which was adopted as a model, long-term (48h) treatment with 18μM caffeic acid phenethyl ester reduced the peak current density by 91% and shifted steady-state inactivation to more hyperpolarized potentials and slowed recovery from inactivation. The effects of long-term treatment were also dose-dependent, 1μM caffeic acid phenethyl ester reducing current density by only 65%. The effects of caffeic acid phenethyl ester on metastatic cell behaviours were tested on the MDA-MB-231 cell line at a working concentration (1μM) that did not affect proliferative activity. Lateral motility and Matrigel invasion were reduced by up to 14% and 51%, respectively. Co-treatment of caffeic acid phenethyl ester ...
Objective(s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has numerous biological effects. In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-β1, TNF-α and prostaglandin E2 (PGE2 ) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF). Materials and Methods: In this study, forty male Sprague-Dawley rats were divided into 5 groups (n=8). (1)
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the anti-inflammatory effects of CAPE on Helicobacter pylori-induced NF-kappaB and AP-1 in the gastric epithelial cell line AGS. Electrophoretic mobility shift assay was used to measure NF-kappaB- and AP-1-DNA binding activity. Western blotting was used to detect IkappaB-alpha and COX-2 expression in AGS cells cocultured with H. pylori. The antiproliferative effect of CAPE was measured by MTT assay. Our results showed that caffeic phenethyl ester inhibits H. pylori-induced NF-kappaB and AP-1 DNA-binding activity in a dose (0.1-25 microg ml(-1) approximately 0.35-88 microM) and time- (15-240 min) dependent manner in AGS cells. Maximum inhibition by CAPE was observed at concentrations of 25 microg ml(-1) ( approximately 88 microM) CAPE prevented H. pylori- and cytokine-induced ...
Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cells. Treatment with CAPE decreased protein abundance of Akt, Akt1, Akt2, Akt3, phospho-Akt Ser473, phospho-Akt Thr 308, GSK3β, FOXO1, FOXO3a, phospho-FOXO1 Thr24, phospho-FoxO3a Thr32, NF-κB, phospho-NF-κB Ser536, Rb, phospho-Rb Ser807/811, Skp2, and cyclin D1, but increased cell cycle inhibitor p27Kip. Overexpression of Akt1 or Akt2 in TW2.6 cells rescued growth inhibition caused by CAPE treatment. Co-treating TW2.6 cells with CAPE and 5-fluorouracil, a commonly used chemotherapeutic drug for oral cancers, exhibited additive cell proliferation inhibition. Our study suggested that administration of CAPE is a
In this Study, it was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) oil cisplatin hepatotoxicity. Thirty New Zealand rabbits were divided into 5 groups as group 1 (saline-injected control, C), group 2 0% ethanol; vehicle for CAPE, E), group 3 (CAPE), group 4 (cisplatin, CS) and group 5 (cisplatin Plus CAPE, CS + CAPE). Cisplatin caused increased immunoreactivity against inducible nitric oxide synthase (iNOS), but CAPE treatment reduced the immunoreactive hepatocytes. Liver malondialdehide (MDA), nitric oxide (NO(center dot)) levels and xanthine oxidase (XO) activities were higher in CS than in groups C and E. Cisplatin treatment also significantly decreased the tissue reduced glutathione (GSH) concentration compared to groups C and E. CAPE administration normalized the tissue GSH level and XO activity in group CS + CAPE, whereas CAPE treatment did not affect MDA level In group CS + CAPE. In addition, CAPE treatment significantly depressed the cisplatin-induced ...
Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats. ...
CAPE (caffeic acid phenethyl ester) is one of the most valuable and investigated component of propolis which is composed by honeybees. In the current study, we aimed at examining apoptotic effects of CAPE on CCRF-CEM leukemic cells and at determining the roles of mitochondrial membrane potential (MMP) in cell death. ...
Background: To investigate the effects of propofol and caffeic acid phenethyl ester (CAPE) on prevention of lung injury as a remote organ after performing hindlimb ischaemia-reperfusion (IR) in a rat model. ...
Caffeic acid phenethyl ester is Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Cited in 17 publications
Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells.. Izuta H1, Shimazawa M, Tsuruma K, Araki Y, Mishima S, Hara H.. Abstract. BACKGROUND:. Vascular endothelial growth factor (VEGF) is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ), bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs).. METHODS:. In an in vitro tube formation assay, HUVECs and fibroblast cells were incubated for 14 days with VEGF and various concentrations of bee products [RJ, ethanol extract of bee pollen, ethanol extract of Chinese red propolis and its constituent, caffeic acid phenethyl ester (CAPE)]. To clarify the mechanism of in vitro angiogenesis, HUVEC proliferation and migration were induced ...
Vascular endothelial growth factor (VEGF) is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ), bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs). In an in vitro tube formation assay, HUVECs and fibroblast cells were incubated for 14 days with VEGF and various concentrations of bee products [RJ, ethanol extract of bee pollen, ethanol extract of Chinese red propolis and its constituent, caffeic acid phenethyl ester (CAPE)]. To clarify the mechanism of in vitro angiogenesis, HUVEC proliferation and migration were induced by VEGF with or without various concentrations of RJ, bee pollen, Chinese red propolis, and CAPE. RJ, bee pollen, Chinese red propolis, and CAPE significantly suppressed VEGF-induced in vitro tube
An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.. Caffeic acid phenethyl ester, or CAPE, is a compound isolated from honeybee hive propolis, the resin used by bees to patch up holes in hives. Propolis has been used for centuries as a natural remedy for conditions ranging from sore throats and allergies to burns and cancer. But the compound has not gained acceptance in the clinic due to scientific questions about its effect on cells.. In a paper published in Cancer Prevention Research, researchers combined traditional cancer research methods with cutting-edge proteomics to find that CAPE arrests early-stage prostate cancer by shutting down the tumor cells system for detecting sources of nutrition.. If you feed CAPE to mice daily, their tumors will stop growing. After several weeks, if you stop the treatment, the tumors will begin to grow ...
Transthyretin (TTR) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic acid phenethyl ester (CAPE) and its derivatives. Thioflavin T assay showed that CAPE suppressed the amyloid fibril formation of TTR. Comparative analysis of the inhibitory potencies revealed that phenethyl ferulate was the most potent among the CAPE derivatives. The binding of phenethyl ferulate and the selected compounds to TTR were confirmed by the 8-anilino-1-naphthalenesulfonic acid displacement and X-ray crystallography. It was also demonstrated that Bio 30, which is a CAPE-rich commercially available New Zealand propolis, inhibited ...
SOURCE: Guney M, et al. (2007). Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. 24(2):86-91.. Fluoride is a strong, hard anion and cumulative toxic agent. The effect of fluoride intoxication on lipid peroxidation in endometrial tissue and the protective effects of combinations of vitamins E and C in rats were studied. Additionally, the apoptotic changes in endometrial tissue were examined. Experimental groups were as follows: control group; a group treated with 100 mg/l fluoride (F group); and a group treated with 100 mg/l fluoride plus vitamins E and C (F+Vit group). The F and F+Vit groups were treated orally with fluoride for 30 days. Vitamins E and C were injected simultaneously at doses of 50 mg/kg day i.m. and 20 mg/kg day body weight i.p. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis, was detected with the use of the terminal deoxynucleotidyl ...
The triple-negative breast cancer (TNBC) patients have a high mortality due to paucity of effective treatments. We have utilized human MDA-MB-231 (MDA-231) BC cells, often serving as a model of TNBC, to determine whether CAPE (caffeic acid phenethyl ester), a major medicinal component of propolis, can combat TNBC as a preventive, therapeutic, and/or adjuvant to chemotherapeutic drugs. We found that CAPE inhibits MDA-231 cell growth in vitro and in vivo. In vitro: CAPE dose-dependently inhibits MDA-231 cell growth and has a strong effect on gene and protein expression without affecting non-tumorigenic cells. It inhibits cell proliferation and anti-apoptotic genes, decreases oncogenes, inflammatory cytokines, cyclins, and certain receptors and growth factors (i.e., EGFR, IGFR-like 1&2, RAR, Egr-1, and NF-\#954;B1&2 transcription factors). CAPE also increases p21 and p27. Notably, CAPE down-regulates mdr-1 gene, considered responsible for the resistance of cancer cells to chemotherapeutic agents, ...
All propolis samples had strong anti-oxidant activity, accompanied by high total phenolic content. The most abundant compounds were flavonoids. Concerning the phenolic compounds content, our results showed that the 75% of the samples analysed contained at least 80 mg/g of flavonoids, primarily pinobanksin 3-acetate, pinocembrin, chrysin, galangin and pinobanksin. Caffeic acid phenethyl ester was detected in almost all EEP samples but in smaller proportions (mean 12.9 ± 2.8 mg/g ...
Cell Culture and Chemicals. SW1116 cells, a cell line derived from human colon adenocarcinoma, were obtained from American Type Culture Collection (Manassas, VA) and cultured in Leibovitzs L-15 medium containing 10% (v/v) heat-inactivated fetal bovine serum, 100 U/ml penicillin, and 100 μg/ml streptomycin. Chemicals were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise stated. Caffeic acid phenethyl ester (CAPE) was purchased from Calbiochem (San Diego, CA), and celecoxib was a kind gift from SEARLE (Evanston, IL).. Estimation of Cell Viability. Cell viability was assayed by routine 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction method. Briefly, SW1116 cells were seeded into a 96-well plate and incubated for 24 h for attachment. They were then incubated with different drugs for different times at 37°C. At the end of incubation, the medium was aspirated. The remaining cells were further incubated with 0.25 mg/ml MTT for 3 h. MTT was extracted with isopropanol ...
CAPE is an effective inhibitor of NF-kappaB activation in PC-3 cells, but the mechanism of apoptosis, and the corresponding loss of IAP expression, is caspase-dependent.
Dietary polyphenol caffeic acid (1) has been reported for various pharmacological activities. The aim of the current study was to investigate the
The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed
PubMed journal article: Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Download Prime PubMed App to iPhone, iPad, or Android
A novel peroxidase that catalyses the dimerization of ferulic acid or caffeic acid via oxidative coupling and formation of beta beta′-linkage to the lignan-type compounds 8,8′-bis(caffeic acid) or 8,8′-bis(ferulic acid) respectively was purified from the leaves of Bupleurum salicifolium. The enzyme, for which the name caffeate peroxidase is proposed, was purified 2700-fold. It is a glycoprotein and has an Mr of 38,000 as determined by gel filtration and SDS/PAGE. The Km values for ferulic acid and caffeic acid were 0.24 mM and for H2O2 0.04 mM with caffeic acid and 0.48 mM with ferulic acid. The purified peroxidase does not exhibit activity on other phenylpropanoids tested and has no detectable phenol oxidase or NADPH oxidase activity. The caffeate peroxidase could be involved in the biosynthesis of lignans. ...
Cryptococcosis, specifically caused by Cryptococcus neoformans, is a subacute or chronic fungal infection with several manifestations. It is commonly observed as a disseminated disease in the immunocompromised patient with approximately two thirds of patients experiencing meningitis.(3,5) Because of the wide spectrum of Cryptococcosis and the opportunistic nature of such infection, rapid laboratory identification of Cryptococcus neoformans is necessary so that therapy can be immediately initiated. The presumptive identification of Cryptococcus neoformans is based on the presence of an encapsulated yeast (using India ink), the absence of pseudohyphae, the failure to utilize an inorganic nitrate substance, and the ability to produce urease. The final identification of C. neoformans is usually based on typical substrate utilization patterns and brown pigment production in the presence of caffeic acid.(2,3,5). The brown pigmented colonies of Cryptococcus neoformans were observed by Staib in 1962 ...
Material Safety Data Sheet of Caffeic acid contains identification of substance and details of the supplier of the safety data sheet.
Authors: A.HAKAN AKTAŞ, GÜLSÜM YAŞAR, GÜLEREN ÖZKAN ALSANCAK, ŞAHİNDE DEMİRCİ Abstract: In this study, four hydroxycinnamic acids, namely 3,4-dihydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy --3- methoxycinnamic acid and 4-hydroxy-3,5-dimethoxycinnamic acid, were titrated conductimetrically and potentiometrically using triethylamine and tetrabutylammonium hydroxide in acetonitrile, 2-propanol, and pyridine solvents under a nitrogen atmosphere at 25 ^oC. In conductimetric titration with tetrabutylammonium hydroxide all of the compounds exhibited conventional stoichiometric titration curves in 2-propanol . As is evident from the titration curves, all these compounds gave two well-defined end points. The first end point corresponds to exactly one equivalent and the second one to the two equivalents of the base. In conductimetric titration with tetrabutylammonium hydroxide, all of the acids (except caffeic acid) show two end points in pyridine solvent. These compounds were ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
In this work, the near-neutral photo-Fenton process, as a means of wastewater disinfection, was enhanced by the addition of Organic Acids (OAs), namely citric, ascorbic, tartaric and caffeic acid. The addition of OAs exhibited significant bacterial inactivation enhancement, compared to the classic photo-Fenton systems (Fe2+/H2O2/solar and Fe3+/H2O2/solar). The improved disinfection performance was not attributed to pH variations by the addition of OAs, but to the increase of the initial dissolved iron in the system, facilitating the Fe3+/Fe2+ turnover in the catalytic photo-Fenton reaction and consequently, the hydroxyl radicals production. For citric and tartaric acid, increased photo-activity of the complexes was associated with their high capability to complex Fe3+ and to promote ligand-to-metal charge transfer (LMCT), which is of key importance to feed Fe2+ to the Fenton process. On the other hand, for ascorbic and caffeic acid, the acceleration of the homogeneous Fenton reaction was ...
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One of the best fragments identified in the previous work was L-tryptophan methyl ester (compound 1), so the researchers naturally tried substituting the methyl group. A phenethyl ester (compound 5c) gave a satisfying 10-fold boost in potency, but this turned out to be the best they could get: shorter or longer linkers were both less active, and modifications around the phenyl ring gave marginal improvements at best. Also, changing the ester to an amide decreased affinity. They were, however, able to improve potency another order of magnitude by acylating the nitrogen (compound 6a ...
Twelve Leuconostoc and seven Weissella strains with extracellular glucansucrase activity were obtained from an analysis of 41 lactic acid bacteria. Culture supernatants of all glucansucrase positive strains catalyzed the glycosylation of caffeic acid with sucrose as donor substrate. Eighteen enzymes produced one major peak, which was identified as caffeic acid-4′-O-α-D-monoglucoside by LC-MS and N ...
Natures Naturals® Propolis is rich in flavonoids, amino acids, and caffeic acid. Propolis has anti-inflammatory and anti-bacterial properties to help fight mild upper respiratory complaints. May help to reduce the severity and duration of the symptoms of colds and flu. It assists with recovery and helps restore good health.. Natures Naturals® Propolis protects and maintains the health of capillaries, Maintain a good blood sugar level, promotes general health and well being.. Natures Naturals® Propolis has an antioxidant property and acts as a free radical scavenger. Free radicals may be generated by lifestyle factors such as dietary fats, cigarette smoke, alcohol consumption, pollutants, and stress.. Directions for use:. Adults only. Take one or two capsules twice daily or as prescribed by your healthcare professional.. WARNING: Propolis may cause allergic reactions. If irritation or swelling of the mouth or throat occurs, discontinue use.. If symptoms persist consult your healthcare ...
Each of the following at 6X, 12X, 30X, 200X, 12CH, 30CH, 60CH, 200CH.. Acetalcholine chloride Combo, Acetaldehyde Combo, Apiolum Combo, Ascorbic Aid Combo, Apiolum Combo, Ascorbic Acid Combo, BHT Combo, Caffeic acid Combo, Candida albicans Combo, Chloragenic acid Combo, Cinnamic acid Combo, Coniferyl alcohol Combo, Coumarin Combo, Dopamin Combo, Estrogen Combo, GABA Combo, Gallic acid Combo, Histamine Combo, Indole Combo, L-Dopa Combo, Malvin Combo, Mannan Combo, Melatonin Combo, Menadione Combo, Noepinephrine Combo, Octopamine Combo, Phenylalanine Combo, Phenylisothiocyanate Combo, Phloridzin Combo, Piperin Combo, Progesterone Combo, Pyrole Combo, Quercetin Combo, Rutin Combo, Salsolinol Combo, Serotonin Combo, Taurine Combo, Testosterone Combo, Tryptophan Combo, ATP 5X, Mesenchyme 6X, 9X, 6C.. ...
Hawthorns active components are mostly flavonoids (luteolin, apigenin, vitexin, rutin, and quercetin as glycosides) and procyanidins. Hawthorn is also a source of tannins or polyphenols (oligomeric cathechins and epicathechins), carboxylic acids (caffeic acid), triterpenes and simple amines (choline, acetylcholine and tyramine). Researchers were unable to find one major active ingredient. It would seem that the therapeutic effect of Hawthorn, like that of many other herbs, rests on the synergy of all of its components.(1). The various in vivo and in vitro studies have identified many of Hawthorns therapeutic effects:. Increase of cardiac contractility (positive inotropic effect). As a result, heart efficiency and ejection fraction are increased.(2). Peripheral resistance reduction (post-charge reduction). The lesser the resistance, the lesser the effort needed by the heart. The final effect is a reduction in oxygen consumption. (2). Coronary vasodilator (improves heart irrigation and oxygen ...
The Stepford Cuckoos episode allowed Anthony and I to discuss a smidgen of what sibling multiples may or may not go through in their lives. As usual, in no way was this a comprehensive discussion, so I figured a few written words could help flesh out the narrative. Unfortunately (fortunately?) I did a bit of reading on the subject, which led to watching something on the subject, which led to confusion, anger, and a willingness to make an apology for my field for something I didnt do... Im a bit off course. Breathe, doc. Your wife always tells you to breathe. I found out about the Dr. Peter Neubauer study involving the Triplets Pizza Brothers. If that sounds like the corny premise for an evening sitcom, its because I didnt mention the intentional separation of families from infants to study their development into adulthood, keeping everyone in secrecy and the ultimate footnote being one of them committing suicide. But hey! At least they learned what type of women they liked and they
Today I had the best views of Cape May Warblers ever during easily the best day of spring migration so far this year. Birds that had been trapped in the Mid-Atlantic for a week or 10 days finally moved north with heavy migration occurring on southerly winds. New England and northern New York had poor migratory conditions still, stopping a lot of birds when they arrived, and some areas of fog and/or rain also helped locally. I thought these couple of shots were the best I would get, and I was happy enough…. ...
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trans-3-coumaric acid 14755-02-3 NMR spectrum, trans-3-coumaric acid H-NMR spectral analysis, trans-3-coumaric acid C-NMR spectral analysis ect.
Homogentisic acid 9 C6-C3 1 Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones Caffeic, ferulic acids, ... Phenolic acids, Phenolic aldehydes Gallic, salicylic acids 8 C6-C2 1 Acetophenones, Tyrosine derivatives, Phenylacetic acids 3- ... Hypogallic acid, caffeic acid, paeoniflorin and pikuroside can be isolated from the freshwater fern Salvinia molesta.[58] ... caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p-hydroxybenzaldehyde, 3,4- ...
They include: alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins. The secondary metabolites are believed ... "Establishment of Adventitious Root Cultures of Echinacea purpurea for the Production of Caffeic Acid Derivatives", Protocols ...
The active ingredient appears to be caffeic acid. Initial experiments on Caffenol were performed in 1995 at the Rochester ... The other ingredients in the basic formula are ascorbic acid and anhydrous sodium carbonate; some recipes also include ... Institute of Technology; addition of ascorbic acid began around 2000, yielding the improved Caffenol-C, which is less likely to ...
Chemical Land [online]. Caffeic Acid as Carbocyclic Carboxylic Acid. Dostupné online.. Zdroj[upraviť , upraviť zdroj]. Tento ... článok je čiastočný alebo úplný preklad článku Caffeic acid na anglickej Wikipédii. ...
Caffeic acid phenethyl ester. Преузето из „https://sr.wikipedia.org/w/index.php?title=Fenetil_estar_kofeinske_kiseline&oldid= ...
... fertaric acids. In wine they are present also in the free form (trans-caffeic, trans-p-coumaric, and trans-ferulic acids).[27] ... The non-flavonoids include the stilbenoids such as resveratrol and phenolic acids such as benzoic, caffeic and cinnamic acids. ... Hydroxycinnammic acids[edit]. Hydroxycinnamic acids are the most important group of nonflavonoid phenols in wine. The four most ... As the wine ages, anthocyanins will react with other acids and compounds in wines such as tannins, pyruvic acid and ...
Zhou JM, Seo YW, Ibrahim RK (April 2009). "Biochemical characterization of a putative wheat caffeic acid O-methyltransferase". ...
Active phytoconstituents include gallic acid, caffeic acid, vanillin, and p-coumaric acid. Cucurbitacin b and isocucurbitacin b ... 1999) isolated rosmarinic acid and their derivatives; isoscutellarein and their derivatives; D-glucopyranosyl isorinic acid ... with rosmarinic acid; helisterculins A and B; and helisorin. The fruits and roots of H. isora are used in traditional medicine ...
Andary, C; Wylde, R; Laffite, C; Privat, G; Winternitz, F (1982). "Structures of verbascoside and orobanchoside, caffeic acid ... Verbascoside is a caffeoyl phenylethanoid glycoside in which the phenylpropanoid caffeic acid and the phenylethanoid ... caffeic acid, decreases the spontaneous mutation rate in the ST cross". Food and Chemical Toxicology. 50 (3-4): 1082-90. doi: ... "Phenylethanoids in the Herb of Plantago lanceolataand Inhibitory Effect on Arachidonic Acid-Induced Mouse Ear Edema1". Planta ...
... caffeic acid sugar esters from Orobanche rapum-genistae". Phytochemistry. 21 (5): 1123-1127. doi:10.1016/S0031-9422(00)82429-2. ...
P. acidus contains 4-hydroxybenzoic acid, caffeic acid, adenosine, kaempferol and hypogallic acid. While the wood is strong and ...
Caffeic acid derivatives, such as caffeoylmalic acid, are also present. The characteristic latex also contains proteolytic ... Hahn, R.; Nahrstedt, A. (1993). "Hydroxycinnamic Acid Derivatives, Caffeoylmalic and New Caffeoylaldonic Acid Esters, from ...
It is a caffeic acid glycoside from the phenylpropanoid class. It is constituted from a trisaccharide consisting of two glucose ... Part 5. Direct synthesis of monoacyltartaric acids and novel mono(benzoyl)tartaric anhydride: unusual findings in tartaric acid ... and one rhamnose moieties glycosidically linked to one caffeic acid and one dihydroxyphenylethanol (hydroxytyrosol) residue at ...
"Caffeic Acid Derivatives in the Roots of Yacon ( Smallanthus sonchifolius )". Journal of Agricultural and Food Chemistry. 51 (3 ... In addition, yacon juice is rich in free essential amino acids. Dry basis ND Not determined Carbohydrate was estimated by the ... Kapuler, A.M; Gurusiddiah, Sarangamat (1993-10-14). "The Twenty Protein Amino Acids Free in the Juices of Our Common Vegetables ... Kapuler, A. M.; Gurusiddiah, Sarangamat (1993-10-14). "The Twenty Protein Amino Acids Free in the Juices of Our Common ...
Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones. Caffeic, ferulic acids, Myristicin, Eugenol, ... Hypogallic acid, caffeic acid, paeoniflorin and pikuroside can be isolated from the freshwater fern Salvinia molesta.[71] ... caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p-hydroxybenzaldehyde, 3,4- ... Gallic, salicylic acids. 8. C6-C2. 1. Acetophenones, Tyrosine derivatives, Phenylacetic acids. 3-Acetyl-6-methoxybenzaldehyde, ...
Other compounds reported to occur in the fruit bodies include gyroporin and caffeic acid. Halling RE, Nuhn M, Fechner NA, ...
Phytochemicals isolated from the herb include terpenes, flavonoids, caffeic acid derivatives and essential oils. Sinensetin is ...
Steck, Warren (1967). "The Biosynthetic Pathway from Caffeic Acid to Scopolin in Tobacco Leaves". Canadian Journal of ... Hino F, Okazaki M and Miura Y (1982). "Effect of 2,4-dichlorophenoxyacetic acid on glucosylation of scopoletin to scopolin in ...
... caffeic acid, curcumin, hyperforin and St John's wort. acetyl-keto-beta-boswellic acid (AKBA), one of the bioactive boswellic ... zileuton and the natural products myxochelins/pseudochelin as well as nordihydroguaiaretic acid (NDGA). Some chemicals found in ... acids found in Boswellia serrata (Indian Frankincense) has been found to inhibit 5-lipoxygenase strongly as an allosteric ...
Amino acids • Bodybuilding supplement • Energy drink • Energy bar • Fatty acids • Herbal Supplements • Minerals • Prebiotics • ... Folic acid (B9) • Cyanocobalamin (B12) • Ascorbic acid (ജീവകം സി) • Ergocalciferol and Cholecalciferol (ജീവകം ഡി) • Tocopherol ... Retinol (ജീവകം എ) • B vitamins: തയാമിൻ (B1) • Riboflavin (B2) • Niacin (B3) • Pantothenic acid (B5) • Pyridoxine (B6) • Biotin ... Lipoic acid • Milk thistle • Melatonin • Red yeast rice • Royal jelly • Saw palmetto • സ്പൈറുലിന • St John's wort • Taurine • ...
... it is an ester formed from quinic acid and two units of caffeic acid. Chlorogenic acid Panizzi, Luigi; Scarpati, Maria Luisa ( ... Cynarine is a hydroxycinnamic acid derivative and a biologically active chemical constituent of artichoke (Cynara cardunculus ...
Flavonoids and caffeic acid derivatives are biosynthesized from phenyl alanine and malonyl-CoA. Complex gallotannins develop ... The gallic acid dimer, ellagic acid (M.W. 302, right), a molecule at the core of naturally occurring phenolic compounds of ... The raspberry ellagitannin (M.W. ~2450),[9] on the other hand, with its 14 gallic acid moieties (most in ellagic acid-type ... Plant-derived polyphenol, tannic acid, formed by esterification of ten equivalents of the phenylpropanoid-derived gallic acid ...
Some examples of these antagonists are caffeic acid, chlorogenic acid, and tannic acid. These compounds interact with the ... Thiamine and its acid metabolites (2-methyl-4-amino-5-pyrimidine carboxylic acid, 4-methyl-thiazole-5-acetic acid, and thiamine ... PDH links glycolysis to the citric acid cycle, while the reaction catalyzed by OGDH is a rate-limiting step in the citric acid ... In particular in E. coli, it seems to play a role in response to amino acid starvation. Adenosine thiamine triphosphate (AThTP ...
... caffeic acid, delphinidin, petunidin, pelargonidin, peonidin, and malvidin. All these except caffeic acid are members of the ... whereas red and purple aronia are richer in phenolic acid and proanthocyanins. The plant produces these pigments mainly in the ... hydroxycinnamic acids, and proanthocyanidins". Journal of Agricultural and Food Chemistry. 61 (36): 8581-8. doi:10.1021/ ...
Several terpenoid alcohols - borneol, cedrol, and menthol - have been extracted, as have caffeic acid and ferulic acid. More ...
Other phenolic compounds present in the plant are hyperoside, chlorogenic acid, and caffeic acid. The two secoiridoid ... Lonicera japonica contains methyl caffeate, 3,4-di-O-caffeoylquinic acid, methyl 3,4-di-O-caffeoylquinate, protocatechuic acid ... Peng, Youyuan; Liu, Fanghua; Ye, Jiannong (2005). "Determination of Phenolic Acids and Flavones in Lonicera japonica Thumb. By ... methyl chlorogenic acid, and luteolin. The two biflavonoids, 3′-O-methyl loniflavone and loniflavone, along with luteolin and ...
augusztus 1.). „CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human ... október 1.). „Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in ...
... and caffeic acids in the basal leaves and the roots of intact plants, and greater concentrations in E. planum from in vitro ... chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.". Acta Physiol Plant. 34: 2425-2433. Media related to ... The groups of bioactive compounds present in E. planum are phenolic acids, triterpenoid saponins, flavonoids, coumarins, and ... Qualitative and quantitative determinations of the phenolic acids by reverse phase high-performance liquid chromatography (RP ...
A protein sample is added to a solution of the dye in phosphoric acid and ethanol. Under the acid conditions the dye is ... The two sulfonic acid groups have extremely low pKa and will normally be negatively charged, thus at a pH of around zero the ... The sheet was then soaked in sulfosalicylic acid to fix the protein bands and then transferred to a solution of the dye.[10] ... Through a study done at the University of Albany, it was shown that the ability of the Coomassie dye to target amino acids with ...
... contains a number of phytochemicals, including rosmarinic acid, camphor, caffeic acid, ursolic acid, betulinic acid, ... carnosic acid, and carnosol.[20] Rosemary essential oil contains 10-20% camphor.[21] ...
... including caffeic acid, vanillic acid, ferulic acid, p-coumaric acid, and benzoic acid, with significant content of calcium, ... and heavy clay soils with acid, neutral, or alkaline chemistry and including soils of low nutritional value. It can tolerate ...
Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol). *Unsorted benzodiazepine site positive ... Quinolines (e.g., 4-hydroxyquinoline, 4-hydroxyquinoline-3-carboxylic acid, 5,7-CIQA, 7-CIQ, 7-TFQ, 7-TFQA) ... Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A (2014). "Beyond bile acids: targeting ... "Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease". Endocrinology and ...
Caffeic acid. *Caffeine. *Coffee bean. *Furan-2-ylmethanethiol. Processing. *Coffee roasting. *Coffee wastewater ...
Chlorogenic acids are homologous compounds comprising caffeic acid, ferulic acid and 3,4-dimethoxycinnamic acid, which are ... The lipids found in green coffee include: linoleic acid, palmitic acid, oleic acid, stearic acid, arachidic acid, diterpenes, ... hexanoic acid (fatty-rancid odor), heptanoic acid (fatty odor), octanoic acid (repulsive oily rancid odor); nonanoic acid (mild ... Nonvolatile chlorogenic acids[edit]. Chlorogenic acids belong to a group of compounds known as phenolic acids, which are ...
Since diacylglycerol is synthesized via phosphatidic acid, it will usually contain a saturated fatty acid at the C-1 position ... or free fatty acids.(See Dietary sources of fatty acids, their digestion, absorption, transport in the blood and storage for ... to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. ... A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol ...
... and caffeic acid, as well as terpenoids, triterpenes, and sesquiterpenes.[40] The roots contain a substantial amount of the ...
Some examples of these antagonists are caffeic acid, chlorogenic acid, and tannic acid. These compounds interact with the ... Thiamine and its acid metabolites (2-methyl-4-amino-5-pyrimidine carboxylic acid, 4-methyl-thiazole-5-acetic acid, and thiamine ... PDH links glycolysis to the citric acid cycle, while the reaction catalyzed by OGDH is a rate-limiting step in the citric acid ... "Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and ...
... phenolics caffeic acid) மற்றும் பீனாலிக் கவுமாரிக் அமிலம் ( p-coumaric acid), பெரூலிக் அமிரம் (the ferulic acid), 8, 5' ... டிபிருலிக் அமிலம் (8,5'-diferulic acid) , பிளேவினாய்டு கேட்டச்சின்-7-0-குளுகோசைடு (flavonoids catechin-7-O-glucoside) [9] , ...
... or GLA (γ-linolenic acid), (INN and USAN gamolenic acid) is a fatty acid found primarily in seed oils. ... This article is about gamma-Linolenic acid. For α-Linolenic acid, see alpha-Linolenic acid. For linoleic acid (no "n"), see ... It is an isomer of α-linolenic acid, which is a polyunsaturated n−3 (omega-3) fatty acid, found in rapeseed canola oil, ... Although GLA is an n−6 fatty acid, a type of acid that is, in general, pro-inflammatory, it has anti-inflammatory properties. ( ...
Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. ... "Molecular cloning and amino acid sequence of leukotriene A4 hydrolase". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6677-81. doi ...
... phytolaccagenic acid (phytolaccinic acid), esculentic acid, and pokeberrygenin,[19] and phytolaccasides A, B, D, E, and G, and ... Seeds contain the phenolic aldehyde caffeic aldehyde.[22] ... and oleanolic acid, and 3-oxo-30-carbomethoxy-23-norolean-12-en ... Other toxic components include triterpene saponins based on the triterpene genins, phytolaccagenin as noted, and jaligonic acid ... oic acid.[19] Triterpene alcohols isolated include α-spinasterol and its glucoside, α-spinasteryl-β-D-glucoside, and a palmityl ...
These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, ...
Caffeic acid. *Caffeine. *Coffee bean. *Furan-2-ylmethanethiol. Preparation. *Arabic coffee. *Jebena ...
Curcumin is a component of the spice turmeric, and caffeic acid is a component high in some fruits and spices.[36] Caffeic acid ... Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into ... There are additional secondary bile acids, such as ursodeoxycholic acid. Deoxycholic acid is soluble in alcohol and acetic acid ... 12α-dihydroxy-5β-cholan-24-oic acid, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic ...
... but its colorful rind displays diverse phenolic acids, such as syringic, coumaric, gallic, caffeic, and ellagic acids having ... Usually, a single light brown seed is found, which is high in certain fats and oils (primarily oleic acid and arachidic acid)[8 ... antioxidant activity in vitro.[20][21] Rambutan seeds contain equal proportions of saturated and unsaturated fatty acids, where ... arachidic (34%) and oleic (42%) acids, respectively, are highest in fat content.[8] ...
7-dimethylaric acid.[5] In another pathway, paraxanthine is broken down into 5-acetylamino-6-formylamino-3-methyluracil through ... and its presence in the blood causes an increase in serum free fatty acid concentration.[8] ... which can then be metabolized by xanthine oxidase to form 1-methyl-uric acid.[7] ...
Caffeic acid. *Caffeine. *Coffee bean. *Furan-2-ylmethanethiol. Preparation. *Arabic coffee. *Jebena ...
3-dimethyluric acid was described by Emil Fischer and Lorenz Ach.[30] The Traube purine synthesis, an alternative method to ...
3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2,2 -dimethyl-propanoic acid ...
Hydroxycinnamic acids. *α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Chicoric acid. *Cinnamic acid ... Dihydroxybenzoic acids. *2,3-Dihydroxybenzoic acid (Hypogallic acid). *2,4-Dihydroxybenzoic acid ...
Caffeic acid. *Caffeine. *Coffee bean. *Furan-2-ylmethanethiol. Preparation. *Arabic coffee. *Jebena ...
Caffeic acid. *Cinnamaldehyde. *Cinnamomum osmophloeum. *Febuxostat. *Myo-inositol. *Kaempferol. *Myricetin. *Niraxostat. * ...
Hydroxycinnamic acids. *α-Cyano-4-hydroxycinnamic acid. *Caffeic acid. *Cichoric acid. *Cinnamic acid ... Short-chain fatty acids[edit]. When fermentable fiber is fermented, short-chain fatty acids (SCFA) are produced. SCFAs are ... Almost all of these short-chain fatty acids will be absorbed from the colon. This means that fecal short-chain fatty acid ... The production of short-chain fatty acids has several possible actions on the gut mucosa. All of the short-chain fatty acids ...
... p-coumaric acid, caffeic acid, and ferulic acid.[30][31] ... Ascorbic acid is vitamin C, which is essential for repairing ... High levels of ROS lead to oxidative stress, which causes damage to lipids, proteins, and nucleic acids. The oxidative damage ... Some of these natural antioxidants include ascorbic acid, tocopherol, and epigallocatechin gallate; they can be found in ... Usenik, Valentina; Fabčič, Jerneja; Štampar, Franci (1 March 2008). "Sugars, organic acids, phenolic composition and ...
Find out more about the possible benefits of caffeic acid. ... Caffeic acid is an antioxidant that is present in all foods. ... Alternatively, people can consider a caffeic acid supplement.. Can I get enough caffeic acid from my diet?. As caffeic acid is ... Other benefits of caffeic acid. Further areas where caffeic acid might be beneficial include:. *Chronic inflammation: Caffeic ... Sources of caffeic acid Caffeic acid is a substance that is present in all plants, including vegetables, fruits, herbs, coffee ...
Other names: Caffeic acid, O,O-bis(tert-butyldimethylsilyl)-, tert-butyldimethylsilyl ester; Caffeic acid, 3TBDMS derivative ... Caffeic acid, TBDMS. *Formula: C27H50O4Si3 ...
Caffeate O-methyltransferase is an enzyme responsible for the transformation of caffeic acid into ferulic acid. Caffeic acid ... 4-dicarboxylic acid). Caffeic acid can also be polymerized using the horseradish peroxidase/H2O2 oxidizing system. Caffeic acid ... Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid ... Caffeic acid is an antioxidant in vitro and also in vivo. Caffeic acid also shows immunomodulatory and anti-inflammatory ...
... C10431 (E)-3-[4-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl] ... Caffeic acid 3-glucoside acid 24959-81-7
Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. It is the ester of caffeic acid and phenethyl ... Huang MT, Smart RC, Wong CQ, Conney AH (November 1988). "Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ... August 2008). "CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human ... Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB (August 1996). "Caffeic acid phenethyl ester is a potent and specific ...
This topic has 11 study abstracts on Caffeic Acid indicating that it may have therapeutic value in the treatment of Breast ... Substances : Alpha Linolenic Acid, Biochanin A, Caffeic Acid, Caffeic acid phenethyl ester, Chlorogenic Acid, Cinnamaldehyde, ... Caffeic acid and caffeic acid phenethyl ester induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.Sep 14, ... Caffeic acid and caffeic acid phenethyl ester Induction of cell cycle arrest and apoptotic response of head and neck squamous ...
Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid ... and 3,5-dicaffeoylquinic acid, three up to now unknown depsides of caffeic acid with glucaric acid have been isolated: 2,5- ... dicaffeoylglucaric acid, 3,4-dicaffeoylglucaric acid, and 2,4- or 3,5-dicaffeoylglucaric acid. ... six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. ...
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. The resulting products ... Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. The resulting products ... Caffeic acid 3-O-methyltransferase (EC:2.1.1.68*Search proteins in UniProtKB for this EC number. ... sp,Q43239,COMT1_ZINVI Caffeic acid 3-O-methyltransferase OS=Zinnia violacea OX=34245 PE=2 SV=1 ...
Caffeic Acid Phenethyl Ester Regulates PPARs Levels in Stem Cells-Derived Adipocytes. Luca Vanella,1 Daniele Tibullo,2 Justyna ... Luca Vanella, Daniele Tibullo, Justyna Godos, et al., "Caffeic Acid Phenethyl Ester Regulates PPARs Levels in Stem Cells- ...
Antimicrobial Potential of Caffeic Acid against,i, Staphylococcus aureus,/i, Clinical Strains ... caffeic acid.. : minimum inhibitory concentration.. : erythromycin.. ICs changes according to the formula [(MIC of antibiotic ... Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains. Table 2. Antibacterial potential of ... caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus. The combined effect of CA ...
Caffeic acid acts as an antioxidant through an iron chelating mechanism, preventing the formation of free hydroxyl radicals and ... Caffeic acid (CA) is a phenolic compound widely found in coffee beans with known beneficial effects in vivo. Many studies ... Caffeic acid acts as an antioxidant through an iron chelating mechanism, preventing the formation of free hydroxyl radicals and ... Antioxidant Activity of Caffeic Acid against Iron-Induced Free Radical Generation-A Chemical Approach. ...
A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited ... Keywords: anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication anti-inflammatory; caffeic acid ... A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited ... Liu Z, Fu J, Shan L, Sun Q, Zhang W. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues ...
... and Insulin-like Growth Factor I Receptor Levels in Human ... Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER(+) (MCF-7) and ER(-) ( ... Substances : Caffeic Acid : CK(43) : AC(25), Caffeine : CK(245) : AC(40) ... CONCLUSION: The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid ...
A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. ... Caffeic Acids. Subscribe to New Research on Caffeic Acids A class of phenolic acids related to chlorogenic acid, p-coumaric ... Carboxylic Acids: 83*Carbocyclic Acids*Cinnamates: 10*Caffeic Acids: 5*Eugenol: 291 ... 01/01/2012 - "Gallic acid and caffeic acids are reported to modulate allergic reactions via unknown mode(s) of action. ". ...
... clarify the role of oxidative stress in streptozotocin induced liver injury and the possible protective effect of caffeic acid ... The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury Bratisl Lek Listy. 2016;117(5):276- ... clarify the role of oxidative stress in streptozotocin induced liver injury and the possible protective effect of caffeic acid ...
Thermo Scientific Remel TOC Agar (Polysorbate 80, Oxgall, Caffeic Acid) is for the presumptive identification of Candida ...
Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Download Prime PubMed App to iPhone, iPad, ... Chlorogenic acid and caffeic acid are absorbed in humans.. *In vitro and in vivo antioxidant properties of chlorogenic acid and ... Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid ... Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid ...
... anti-inflammatory and immunomodulating properties of rosmarinic acid. Characteristics of the parameters of optimal extraction ... Caffeic and rosmarinic acids in thyme species. Analysis of the study of antioxidant, anti-inflammatory and immunomodulating ... properties of rosmarinic acid. Characteristics of the parameters of optimal extraction of biologically active compounds of ...
Bout S, Vermerris W (2003) A candidate-gene approach to clone the sorghum brown midrib gene encoding caffeic acid O- ... Transcription activator-like effector nucleases Genome editing Caffeic acid O-methyltransferase Lignin Sugarcane Capillary ... 2016). Here, we report TALEN mediated targeted mutagenesis of the lignin biosynthetic gene, caffeic acid O-methyltransferase ( ... TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall ...
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. K ... Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B ... Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B ... Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B ...
... vanillic acid, rosmarinic acid, myricetin (4 μg/ml each), caffeic acid, Syringic acid, vanillin, trans-ferulic acid (3 μg/ml ... vanillic acid (VA), caffeic acid (CA), Syringic acid (SA), (−)-epicatechin (EC), vanillin (VL), p-coumaric acid (PCA), trans- ... Peaks: 1, caffeic acid; 2, syringic acid; 3, (−)-epicatechin; 4, vanillin; 5, benzoic acid; 6, kaempferol ... caffeic acid and syringic acid and benzoic acid. This study also pointed out that oxidative stress can be reduced by Citrus ...
Ji-Yeon Lee, Hee-Jung Choi, Tae-Wook Chung, Cheorl-Ho Kim, Han-Sol Jeong, Ki-Tae Ha, Caffeic Acid Phenethyl Ester Inhibits ... S1. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4+ T cells. CD4+ T cells (106 cells/ml) were ... S2. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4+ T cells. CD4+ T cells (106 cells/ml) ... S5. Caffeic acid phenethyl ester (CAPE) induces active caspase-3 expression in polarized T helper type 1 (Th1) and Th2 cells. ...
5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to ... The absorption and metabolism in the small intestine of chlorogenic acid ( ... 0/Antioxidants; 0/Caffeic Acids; 0/Coumaric Acids; 0/Hydroxybenzoic Acids; 29656-58-4/phenolic acid; 327-97-9/Chlorogenic Acid ... Caffeic Acids / metabolism*, pharmacokinetics. Chlorogenic Acid / metabolism*, pharmacokinetics. Coumaric Acids / ...
The Structure of an ABC-Transporter Family Protein from Rhodopseudomonas palustris in Complex with Caffeic Acid. ... Putative branched-chain amino acid transport system substrate-binding protein 1076 4 3UKJ 1 A Extracellular ligand-binding ... Putative branched-chain amino acid transport system substrate-binding protein 1076 7 4EYQ 1 A Extracellular ligand-binding ... branched-chain amino acid transport system substrate-binding protein Aromatic compound transport protein 1076 ...
Keywords: caffeic acid phenyl ester, palatal mucosa, tooth extraction socket, healing ... The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and ... Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets Ahmet Günay,1 Osman Fatih Arpağ ... and caffeic acid phenethyl ester (palatal mucosal defect treated with caffeic acid phenethyl ester [caffeic acid phenethyl ...
Caffeic Acid (UNII: U2S3A33KVM) (Caffeic Acid - UNII:U2S3A33KVM) Caffeic Acid. 200 [kp_C] in 1 mL. ... Caffeic acid 6X 200K, Candida Albicans 30X 200K, Chrysanthemum parthenium 30X, 200K, Hydrocotyle Asiatica 6X 200K, Mannan 6X ... caffeic acid, candida albicans, tanacetum parthenium, centella asiatica, yeast mannan, vaccinium vitis-idaea leaf spray spray. ... CANDIDA I- caffeic acid, candida albicans, tanacetum parthenium, centella asiatica, yeast mannan, vaccinium vitis-idaea leaf ...
Forestomach and Kidney Carcinogenicity of Caffeic Acid in F344 Rats and C57BL/6N × C3H/HeN F1 Mice. Akihiro Hagiwara, Masao ... The carcinogenic potential of caffeic acid was investigated in both sexes of F344 rats and C57BL/6N × C3H/HeN F1 mice. After ... Forestomach and Kidney Carcinogenicity of Caffeic Acid in F344 Rats and C57BL/6N × C3H/HeN F1 Mice ... Forestomach and Kidney Carcinogenicity of Caffeic Acid in F344 Rats and C57BL/6N × C3H/HeN F1 Mice ...
Caffeic acid phenethyl ester is Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Cited in ... Caffeic acid phenethyl ester Citazioni prodotti Vedi quanti altri hanno usato Caffeic acid phenethyl ester. Clicca sulla voce ... CAPE (Caffeic acid phenethyl ester) is a constituent of the propolis of honeybee hives and has been shown to contain inhibitory ... Caffeic acid phenethyl ester (CAS 104594-70-9) *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
INDOFINE Chemical Company supplies CAFFEIC ACID natural for pharmaceutical, agricultural and life science industries. We ...
CAFFEIC ACID (UNII: U2S3A33KVM) (CAFFEIC ACID - UNII:U2S3A33KVM). CAFFEIC ACID. 6 [hp_X] in 1 mL. ... CHLOROGENIC ACID. 6 [IR] in 1 mL. CINNAMIC ACID (UNII: U14A832J8D) (CINNAMIC ACID - UNII:U14A832J8D). CINNAMIC ACID. 6 [hp_X] ... Label: ALLERPHENEX I- acetaldehyde, acetylcholine chloride, adrenalinum, caffeic acid, chlorogenic acid, cinnamic acid, ... ALLERPHENEX I- acetaldehyde, acetylcholine chloride, adrenalinum, caffeic acid, chlorogenic acid, cinnamic acid, coumarinum, ...
  • Caffeic acid has a variety of potential pharmacological effects in in vitro studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma cell line has recently been established. (wikipedia.org)
  • The aim of the present study was to clarify the role of oxidative stress in streptozotocin induced liver injury and the possible protective effect of caffeic acid phenethyl ester (CAPE) using histological and biochemical parameters. (nih.gov)
  • The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4 + T cells. (wiley.com)
  • The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4 + T cells. (wiley.com)
  • The aim of the current study was to investigate the effect of caffeic acid ( 1 ) on ethylene glycol-induced renal stones in rats. (springermedizin.de)
  • In this Study, it was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) oil cisplatin hepatotoxicity. (inonu.edu.tr)
  • Inhibitory effect of caffeic acid phenet. (medeniyet.edu.tr)
  • Neuroprotective effect of caffeic acid under oxidative stress induced by H 2 O 2 was investigated with [3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MTT) and lactate dehydrogenase (LDH) assays. (biomedcentral.com)
  • A 2000 study looked at the effects of caffeic acid on oral cancer cells. (medicalnewstoday.com)
  • Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid in humans. (wikipedia.org)
  • Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice. (greenmedinfo.com)
  • The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model. (dovepress.com)
  • Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats. (marmara.edu.tr)
  • In this experimental study, we investigated the preventive or attenuating effects of caffeic acid phenethyl ester (CAPE) that has been demonstrated to have anti-inflammatory, cytocytatic, anti cancerogenic, antiprolipherative and antioxidant effects on BLM-induced PF. (medeniyet.edu.tr)
  • Caffeic acid and its derivative caffeic acid phenethyl ester (CAPE) are produced in many kinds of plants. (wikipedia.org)
  • Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. (wikipedia.org)
  • Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. (pnas.org)
  • Besides TNF, CAPE also inhibited NF-kappa B activation induced by other inflammatory agents including phorbol ester, ceramide, hydrogen peroxide, and okadaic acid. (pnas.org)
  • Caffeic acid phenethyl ester (CAPE), an active component in propolis, is known to have anti-tumour, anti-inflammatory and anti-oxidant properties. (wiley.com)
  • Caffeic acid phenethyl ester (CAPE) inhibits interferon (IFN)-γ and interleukin (IL)-5 production by polarized T helper type 1 (Th1) and Th2 cells. (wiley.com)
  • Caffeic acid phenethyl ester (CAPE) inhibits proliferation of polarized T helper type 1 (Th) and Th2 cells. (wiley.com)
  • Caffeic acid phenethyl ester (CAPE) is a biologically active ingredient extracted from propolis that is used for the isolation and disinfection of hives. (dovepress.com)
  • CAPE (Caffeic acid phenethyl ester) is a constituent of the propolis of honeybee hives and has been shown to contain inhibitory effects on induced papilloma promotion in mice. (scbt.com)
  • The anti-inflammatory characteristics have been thought to be due to suppression of the lipoxygenase pathway of arachidonic acid metabolism by CAPE. (scbt.com)
  • CAPE (Caffeic Acid Phenethylester) is an inhibitor of ODC and Tyrosine Kinase. (scbt.com)
  • For these tests, new antimicrobial bone-cement was prepared using a caffeic acid phenethyl ester (CAPE) compound from natural propolis, and an antibiotic bone-cement was prepared by the inclusion of gentamycin (GM). (rsc.org)
  • To investigate the effects of a novel agent, caffeic acid phethyl ester (CAPE) on nuclear factor (NF)-kappaB activation and apoptosis in the androgen-independent PC3 prostate cancer cell line. (nih.gov)
  • Caffeic acid phenethyl ester (CAPE) was isolated from propolis (a product of honeybee hives) that has been used in folk medicine as a potent antiinflammatory agent. (aacrjournals.org)
  • Caffeic acid phenethyl ester (CAPE), which is derived from the propolis of honeybee hives, has been shown to reveal anti-inflammatory properties. (aspetjournals.org)
  • Caffeic acid phenethyl ester (CAPE) is an active phenolic compound present in propolis, which is the generic name of a resinous product derived from the bark of conifer trees and carried by honeybees to their hives. (aspetjournals.org)
  • Caffeic Acid Phenethyl Ester (CAPE), a polyphenolic compound found in propolis, has been shown to protect a variety of cells types against ROS in vitro and has also been shown to induce a variety of genes including hemeoxygenase 1 (HMOX-1) , an enzyme that has been implicated in a cytoprotective pathway. (utexas.edu)
  • We have synthesized a series of CAPE amide derivatives, including Caffeic Acid Phenethyl Amide (CAPA), with the aim of improving CAPE's stability properties while maintaining the cytoprotective effects of the parent compound. (utexas.edu)
  • Caffeic Acid Phenethyl Ester (CAPE) is a key component in New Zealand propolis, known for a variety of health promoting and therapeutic potentials. (jcancer.org)
  • Of note, we found that whereas CAPE was unstable in the culture medium (as it gets degraded into caffeic acid by secreted esterases), its complex with gamma cyclodextrin (γCD) showed high efficacy in anti-tumor and anti-metastasis assays in vitro and in vivo (when administered through either intraperitoneal or oral route). (jcancer.org)
  • The aim of this study was to investigate the antioxidant and radioprotective effects of propolis, caffeic acid phenethyl ester (CAPE), Nigella sativa oil (NSO), and thymoquinone (TQ) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with single dose of 5-Gy cobalt-60 gamma rays. (springermedizin.at)
  • Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. (tcd.ie)
  • Several studies have suggested that caffeic acid phenethyl ester (CAPE) can induce the expression of hypoxia inducible factor-1α (HIF-1α) protein. (biomedcentral.com)
  • Caffeic acid's derivative caffeic acid phenethyl ester (CAPE) has been shown to protect against hyperthermal stress induces by prolonged exercise [2]. (nutrientjournal.com)
  • Sourced by bees from New Zealand's native plants in remote pristine areas, BIO30 New Zealand Propolis was found by researchers to contain particularly high levels of the active bioflavonoids and caffeic acid phenethyl ester (CAPE) responsible for the unique activity of propolis, compared to bee propolis of other origins. (bio30.com)
  • Background: To investigate the effects of propofol and caffeic acid phenethyl ester (CAPE) on prevention of lung injury as a remote organ after performing hindlimb ischaemia-reperfusion (IR) in a rat model. (bezmialem.edu.tr)
  • Caffeic acid phenethyl ester (CAPE) exerts pharmacological actions (e.g. anti-inflammatory, chemopreventive) which are relevant for potential clinical application in the digestive tract. (elsevier.com)
  • CAPE reduced (in a tetrodotoxin-insensitive manner) spontaneous ileal contractions and this effect was reduced by the L-type Ca2+ channel blocker nifedipine and the chelant of calcium ethylenediaminetetraacetic acid. (elsevier.com)
  • Caffeic acid phenethyl ester (CAPE) is an active component of honeybee propolis extracts. (semanticscholar.org)
  • Caffeic Acid Phenethyl Ester (CAPE), a component of propolis, showed a preventive effect against both depression- and anxiety-like symptoms when administered during the stress loading, and CAPE also displayed a therapeutic effect against both symptoms when administered after the stress loading. (jscholaronline.org)
  • Effects of Intrathecal Caffeic Acid Phenethyl Ester (CAPE) on IL-6 and TNF-α Levels and Local Inflammatory Responses in Spinal Cord Injuries. (greenmedinfo.com)
  • To investigate the effects of intrathecal caffeic acid phenethyl ester (CAPE) on tissue and serum IL-6 and TNF-α levels following spinal cord injury (SCI) as well as its effects on edema and microhemorrage. (greenmedinfo.com)
  • Ka mor'a tsamaiso, Raw Caffeic acid e bitsoang phenethyl ester powder (CAPE) e thibela ho sebelisoa ha NF-kappa B e nkiloeng ka nyutlelie 'me e ka thibela p70S6K le litsela tsa ho tsebahatsa Akt. (phcoker.com)
  • Litšobotsi tse khahlanong le ho ruruha li 'nile tsa nahana hore li bakoa ke ho tlosoa ha lipoxygenase tsela ea arachidonic acid metabolism ke CAPE. (phcoker.com)
  • The structure-activity relationship was used to describe the antioxidant pharmacophore of caffeic acid phenethyl ester (CAPE) and chrysin by using quantum chemical calculations and the density functional theory method. (propolisscience.org)
  • Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. (ac.ir)
  • Propolis is a mixture having hundreds of polyphenols including caffeic acid phenethyl ester (CAPE). (propolisscience.org)
  • Caffeic acid phenethyl ester CAPE is a polyphenolic compound present in many medicinal plants and in propolis. (duhnnae.com)
  • Similarly to other antioxidants, caffeic acid may also slow the physical aging process. (medicalnewstoday.com)
  • Caffeic acid outperformed the other antioxidants, reducing aflatoxin production by more than 95 percent. (wikipedia.org)
  • In the same study, high doses of combined antioxidants, including caffeic acid, showed a significant decrease in growth of colon tumors in those same rats. (wikipedia.org)
  • Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model. (nutrientjournal.com)
  • Oleanolic acid is present in calendula, it has the properties of anti bacterial, antiseptic and antioxidants which are beneficial for the human body. (ayurvediccure.com)
  • Again, these results suggest that caffeic acid might be a viable treatment for some types of breast cancer. (medicalnewstoday.com)
  • These results suggest that caffeic acid ( 1 ) can be further investigated for the prevention, and treatment of kidney stones. (springermedizin.de)
  • These results suggest that caffeic acid exhibits peripheral analgesic effect in mice and rats and could be further examined for the treatment of chronic painful episodes. (elsevier.com)
  • A total of 74 Sprague-Dawley rats were divided into 8 groups to test the radioprotective effectiveness of Nigella sativa oil, thymoquine, propolis, or caffeic acid phenethyl ester administered by either orogastric tube or intraperitoneal injection. (springermedizin.at)
  • Caffeic acid phenethyl ester, an antioxidant from propolis, protects peripheral blood mononuclear cells of competitive cyclists against hyperthermal stress. (nutrientjournal.com)
  • Peso ea Rafi ea Caffeic acid e phofshoana ea ester ke phenethyl alcohol ester ea acid e caffeic le karolo ea bioactive ea honeybee hive propolis, e nang le li-antineoplastic, mesebetsi ea cytoprotective le immunomodulating. (phcoker.com)
  • Caffeic acid e bitsoang phenethyl ester ke karolo ea propolis ea mahe a linotši, e thibela ho ts'oaroa ha NF-κB e bakoang ke phorbol ester, ceramide, okadaic acid, le hydrogen peroxide ka ho thibela phetoho ea karoloana ea p65 ea NF-κB ho ea lehaeng. (phcoker.com)
  • Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity? (propolisscience.org)
  • The carcinogenic potential of caffeic acid was investigated in both sexes of F344 rats and C57BL/6N × C3H/HeN F 1 mice. (aacrjournals.org)
  • Antioxidant potential of caffeic acid has been shown in vitro and also in vivo [3,4]. (nutrientjournal.com)
  • Furthermore, a 2014 study showed caffeic acid derivatives inhibited the growth of colon cancer cells, both in vitro and in vivo. (medicalnewstoday.com)
  • Caffeic Acid Derivatives from Eupatorium perfoliatum L. (mdpi.com)
  • From the ethyl acetate soluble fraction of a methanol/water extract of the herb Eupatorium perfoliatum L. (Asteraceae) six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. (mdpi.com)
  • Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid) and 3,5-dicaffeoylquinic acid, three up to now unknown depsides of caffeic acid with glucaric acid have been isolated: 2,5-dicaffeoylglucaric acid, 3,4-dicaffeoylglucaric acid, and 2,4- or 3,5-dicaffeoylglucaric acid. (mdpi.com)
  • Hensel, A. Caffeic Acid Derivatives from Eupatorium perfoliatum L.. Molecules 2009 , 14 , 36-45. (mdpi.com)
  • Maas M, Petereit F, Hensel A. Caffeic Acid Derivatives from Eupatorium perfoliatum L.. Molecules . (mdpi.com)
  • This hypothesis was tested using the paradigmatic caffeic acid (CA) and two of its ester derivatives, rosmarinic (RA) and chlorogenic (CGA) acids, for which we predict, based on molecular dynamics simulations, a shallow location in phospholipid bilayers dependent on the protonation-state. (ovid.com)
  • Three species of Plantago and three varieties of Plantago major L. were grown in greenhouse and outdoors to investigate effects on the content and composition of three bioactive caffeic acid derivatives (BCAD) (plantamajoside, iso-plantamajoside and verbascoside), free amino acids (FAA) and leaf texture of the plants. (ajol.info)
  • In nature, they are associated with other molecules to form, e.g., glycosylated derivatives or esters of tartaric acid, quinic acid, or shikimic acid . (tuscany-diet.net)
  • For example, an overlong storage of blood orange fruits causes a massive hydrolysis of hydroxycinnamic derivatives to free acids, and this in turn could lead to the formation of malodorous compounds such as vinyl phenols, indicators of too advanced senescence of the fruit. (tuscany-diet.net)
  • Both heterocycle esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against HeLa, SK-OV-3, and HT-29 cancer cell lines. (ac.ir)
  • Caffeic acid is believed to have potential anti-inflammatory and antioxidant properties, both of which are of increasing interest to medical researchers. (medicalnewstoday.com)
  • Like many other polyphenols, caffeic acid is an antioxidant . (medicalnewstoday.com)
  • Some skin and body care companies add caffeic acid to products because of its antioxidant properties. (medicalnewstoday.com)
  • Caffeic acid is an antioxidant in vitro and also in vivo. (wikipedia.org)
  • Caffeic Acid has significant potential as an antidiabetic agent via attenuation of glucose output, increased glucose uptake, increased insulin secretion and antioxidant capacity. (greenmedinfo.com)
  • Caffeic acid acts as an antioxidant through an iron chelating mechanism, preventing the formation of free hydroxyl radicals and inhibiting fenton induced oxidative damage. (greenmedinfo.com)
  • Antioxidant Activity of Caffeic Acid against Iron-Induced Free Radical Generation-A Chemical Approach. (greenmedinfo.com)
  • Analysis of the study of antioxidant, anti-inflammatory and immunomodulating properties of rosmarinic acid. (allbest.ru)
  • To slow down this process, researchers from Aarhus University have found a way of adding caffeic acid-which is an antioxidant-to various emulsifiers. (dtu.dk)
  • In her research, Betül Yesiltas has shown that by adding caffeic acid to an emulsifier it works in two ways: It forms a physical barrier against the environment while also acting as an antioxidant right where the oxidation processes start. (dtu.dk)
  • Caffeic acid , chlorogenic acid and quercetin has also been found in chia oil, these compounds are known to have antioxidant properties [16]. (thefreedictionary.com)
  • Furthermore, this study investigates the effect of long-term exposure of soybean to exogenous caffeic acid (CA) and salt stress, on the basis of the established role of CA as an antioxidant and the involvement of antioxidant enzymes in plant salt stress responses. (uwc.ac.za)
  • Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. (abmole.com)
  • Green dwarf coconut water, caffeic and ascorbic acids have antioxidant, hepatoprotective and reduced DNA damage properties. (greenmedinfo.com)
  • Besides its antioxidant properties one animal study also showed significant reduction of the blood glucose after caffeic acid ingestion [4]. (nutrientjournal.com)
  • Therefore, caffeic acid demonstrates significant potential as an antidiabetic agent by an attenuation of liver glucose output and enhancement of adipocyte glucose uptake, insulin secretion, and antioxidant capacity. (nutrientjournal.com)
  • Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. (nutrientjournal.com)
  • Caffeic acid e bitsoang phenethyl ester, e le antioxidant e matla, e na le phello ea eona e khahlanong le apoptotic liseleng tsa grerele tsa cerebellar ka ho thibela sebopeho sa ROS le ho thibela mosebetsi oa caspase. (phcoker.com)
  • Theoretical, antioxidant and cytotoxic activities of caffeic acid phenethyl ester and chrysin. (propolisscience.org)
  • Antioxidant activities of the fractions from Erigeron annuus leaf were examined with [2,2-azino-bis(3-ethylbenz thiazoline-6-sulfonic acid diammonium salt)] (ABTS) and ferric reducing antioxidant power (FRAP) assays. (biomedcentral.com)
  • Caffeic acid, an isolated active compound from butanol fraction, showed dose-dependent in vitro antioxidant activity. (biomedcentral.com)
  • These fragrant acids are part of an even larger group of chemicals called polyphenols. (medicalnewstoday.com)
  • The main polyphenols, chlorogenic acids and caffeic acid (not related to caffeine), are demethylating agents, meaning they thwart the addition of methyl groups to DNA. (thefreedictionary.com)
  • Hydroxycinnamic acids or hydroxycinnamates are phenolic compounds belonging to non-flavonoid polyphenols . (tuscany-diet.net)
  • Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer. (greenmedinfo.com)
  • On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. (unboundmedicine.com)
  • Caffeic and ferulic acids were grafted onto chitosan by a free radical mediated method. (naver.com)
  • One study from 2015 used 1,090 people with breast cancer to look at the effect of caffeine and caffeic acid on breast cancer growth in relation to the condition's estrogen receptor status. (medicalnewstoday.com)
  • It concluded that caffeine and caffeic acid demonstrated anticancer properties and suppressed the growth of estrogen receptor cells. (medicalnewstoday.com)
  • Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid (esterified through a side chain alcohol). (wikipedia.org)
  • Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer. (greenmedinfo.com)
  • Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER(+) (MCF-7) and ER(-) (MDA-MB-231) breast cancer cells. (greenmedinfo.com)
  • Caffeine and caffeic acid suppressed the growth of ER(+) (P ≤ 0.01) and ER(-) (P ≤ 0.03) cells. (greenmedinfo.com)
  • The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER + and ER − breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth. (aacrjournals.org)
  • Mechanistically, this study shows that predominantly caffeine, but also caffeic acid, mimics the actions of antiestrogens and modifies major growth regulatory pathways ER/cyclin D1 and IGFIR/pAkt, resulting in impaired cell-cycle progression and reduced cellular proliferation. (aacrjournals.org)
  • Agunloye, Odunayo 2018-06-01 00:00:00 Caffeine (CA) and caffeic acid (CAF) are two bioactive phytochemicals found richly distributed in many plant foods such as coffee in different proportions. (deepdyve.com)
  • Caffeic acid ( 3,4-dihydroxycinnamic acid , 3,4-DA ) is an organic compound found in many plants and foods, which is unrelated to caffeine. (nutrientjournal.com)
  • Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid. (uniprot.org)
  • In this study, SERS measurements were systematically evaluated for ferulic acid, p-coumaric acid, caffeic acid and sinapic acid. (nofima.no)
  • In particular, sinapic acid was evaluated for the first time, with a limit of detection of 2.5 × 10−9 M. (nofima.no)
  • In addition, several hundreds of anthocyanins acylated with the aforementioned hydroxycinnamates have been identified (in descending order with p-coumaric acid, more than 150, caffeic acid, about 100, ferulic acid, about 60, and sinapic acid, about 25). (tuscany-diet.net)
  • In turn, ferulic acid is converted into sinapic acid through two reactions: a hydroxylation at the 5-position to form 5-hydroxy ferulic acid (reaction catalysed by ferulate 5-hydroxylase), and the subsequent O -methylation of the same hydroxyl group (reaction catalyzed by catechol- O- methyltransferase). (tuscany-diet.net)
  • The studies are the first to show that oxidative stress that would otherwise trigger or enhance Aspergillus flavus aflatoxin production can be stymied by caffeic acid. (wikipedia.org)
  • Also, caffeic acid treatment attenuated lipopolysaccharide (LPS)-induced sickness behaviour in experimental animals by decreasing both peripheral and central cytokine levels along with oxidative stress inflicted by LPS. (wikipedia.org)
  • Modified phosphatidylcholine with different alkyl chain length and covalently attached caffeic acid affects the physical and oxidative stability of omega-3 delivery 70% oil-in-water emulsions (pdf). (dtu.dk)
  • and it also remains unknown that caffeic acid or ellagic acid could protect cardiac tissue against diabetes associated dyslipidemia, hypercoagulability, oxidative stress and inflammation. (biomedcentral.com)
  • Although quinic acid failed, chlorogenic and caffeic acids significantly ameliorated the H2O2-induced decline in TTC staining intensities. (thefreedictionary.com)
  • Caffeic acid and quinic acid bind to form chlorogenic acid, present in many fruit and in high concentration in coffee. (tuscany-diet.net)
  • In contrast to numerous flavonoids, absorbed phenolic acids are poorly excreted in the bile or gut lumen. (biomedsearch.com)
  • Most research has found that caffeic acid can slow or reverse inflammation . (medicalnewstoday.com)
  • Research has also found that caffeic acid is safe, even in relatively large doses. (medicalnewstoday.com)
  • That study found that caffeic acid could target a chemical that helps a specific type of breast cancer cell reproduce. (medicalnewstoday.com)
  • A 1996 study found that caffeic acid could target a specific source of inflammation, both in a petri dish and in the human body. (medicalnewstoday.com)
  • Research in mice has found that caffeic acid may combat some effects of diabetes . (medicalnewstoday.com)
  • A 2009 study of diabetic mice found that caffeic acid could raise blood insulin levels, lower blood glucose, and fight inflammation. (medicalnewstoday.com)
  • We found that caffeic acid had a low cytotoxicity and significantly inhibited UVB-induced cytotoxicity on HFDPCs. (e-ajbc.org)
  • HPLC-DAD analysis of Citrus macroptera extract showed the great presence of caffeic acid and (−) epicatechin. (springer.com)
  • The final identification of C. neoformans is usually based on typical substrate utilization patterns and brown pigment production in the presence of caffeic acid. (hardydiagnostics.com)
  • As a result, Cryptococcus neoformans may be differentiated from other yeasts and from other Cryptococcus species by the production of brown pigment in the presence of caffeic acid and ferric citrate. (hardydiagnostics.com)
  • 12 ] reported that oral administration of caffeic acid resulted in the presence of its intact form in mice liver. (biomedcentral.com)
  • Oral administration of caffeic acid (200 mg/kg, p.o.) showed analgesic activity similar to nimesulide (4 mg/kg, p.o.) and inhibited MPO, MDA and nitrite generation in the inflamed paw. (elsevier.com)
  • Background: Caffeic acid phenethyl ester and Dasatinib in combination, when used incongruous proportions and durations, present an antitumor potential for glioma in vitro, suggesting a high therapeutic potential for glioma treatment. (eurekaselect.com)
  • Caffeic acid (CA) is a phenolic compound widely found in coffee beans with known beneficial effects in vivo. (greenmedinfo.com)
  • Ka vivo, Caffeic acid e phenethyl ester (10 mg / kg, ip) e thibela kholo le angiogenesis ea lihlahala tse ka sehloohong ho C57BL / 6 le BALB / c mice e kenngoeng ka Lewis lung carcinoma, colon carcinoma le lisele tsa melanoma. (phcoker.com)
  • Caffeic acid e bitsoang phenethyl ester (5, 10, 20 mg / kg) e boetse e bontša liphello tsa immunomodulatory in vivo ka ho fokotsa thymus boima le / kapa cellularity ea thymus le spleen. (phcoker.com)
  • More recent data show that bacteria in the rats' guts may alter the formation of metabolites of caffeic acid. (wikipedia.org)
  • Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. (unboundmedicine.com)
  • Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. (unboundmedicine.com)
  • Chlorogenic and caffeic acids were perfused into a segment of ileum plus jejunum during 45 min (50 microm, 0.75 ml/min) using an in situ intestinal perfusion rat model with cannulation of the biliary duct, and were quantified together with their metabolites in perfusion effluent, bile and plasma. (biomedsearch.com)
  • The net absorption (influent flux minus effluent flux of phenolic acids and their metabolites) accounted for 19.5 % and 8 % of the perfused caffeic and chlorogenic acids, respectively. (biomedsearch.com)
  • In conclusion, caffeoylisocitric acid from amaranth, which is a source of several esterified phenolic acids in addition to chlorogenic acid, can be metabolized by the human gut microbiota, but the metabolites produced vary between individuals. (elsevier.com)
  • Oral administration of high doses of caffeic acid in rats has caused stomach papillomas. (wikipedia.org)
  • Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. (unboundmedicine.com)
  • Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats. (biomedsearch.com)
  • The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed or hydrolysed in the small intestine. (biomedsearch.com)
  • Short-chain fatty acid formation in the hindgut of rats fed native and fermented oat fibre concentra. (biomedsearch.com)
  • Thus, the current investigation showed caffeic acid to exert carcinogenic activity for the forestomach squamous cell epithelium in both sexes of F344 rats and C57BL/6N × C3H/HeN F 1 mice, for the renal tubular cell in male rats and female mice, and for the alveolar type II cell in male mice. (aacrjournals.org)
  • Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique. (biomedsearch.com)
  • Zn absorption was significantly less in rats fed on chlorogenic acid or caffeic acid than in the control group. (biomedsearch.com)
  • The results indicated that in both the preventive and curative groups, treatment of rats with caffeic acid ( 1 ) significantly regulated the altered biochemical parameters, along with the remarkable reduction of calcium oxalate deposits in the kidneys, as compared to the pathological group. (springermedizin.de)
  • Caffeic acid supplementation has a protective effect against fluoride induced hepatotoxicity in rats. (greenmedinfo.com)
  • 3, 4-Dihydroxycinnamic Acid Attenuates the Fatigue and Improves Exercise Tolerance in Rats. (nutrientjournal.com)
  • Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats? (bezmialem.edu.tr)
  • The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice and rats. (elsevier.com)
  • Caffeic acid was chosen as representative of the phenolic acids since it has also been demonstrated to be inhibitory on adipogenesis [27]. (thefreedictionary.com)
  • The combination of variable-temperature two-dimensional proton-proton double quantum filter correlation spectroscopy (H-1-H-1 DQF COSY) and proton-carbon heteronuclear multiple quantum coherence (H-1-C-13 HMQC) gradient NMR spectroscopy allows the identification and tentative quantification of caffeic and rosmarinic acids at 243 K in extracts from plants of the Lamiaceae family, without resorting to previous chromatographic separation of the components. (openarchives.gr)
  • Naturally occurring phenolic acids (PAs) are key compounds involved in the metabolism of plants and necessary building blocks for the polyphenol biosynthetic pathways to lignins, coumarins, lignans, stilbenes, and many other families of phenolic compounds ( Shahidi and Nazck, 2004 ). (frontiersin.org)
  • E boetse e bontšitsoe ho thibela haholo lipoxygenase tsela ea arachidonic acid e metabolism nakong ea ho ruruha. (phcoker.com)
  • This enzyme catalyzes the deamination of phenylalanine to yield trans -cinnamic acid, so linking the aromatic amino acid to the hydroxycinnamic acids and their activated forms. (tuscany-diet.net)
  • In the first step, a hydroxyl group is attached at the 4-position of the aromatic ring of trans -cinnamic acid to form p-coumaric acid (reaction catalysed by cinnamic acid 4-hydroxylase). (tuscany-diet.net)
  • The addition of a second hydroxyl group at the 3-position of the ring of p-coumaric acid leads to the formation of caffeic acid (reaction catalysed by p-coumarate 3-hydroxylase or phenolase), while the O -methylation of the hydroxyl group at the 3-position yields ferulic acid (reaction catalyzed by catechol- O -methyltransferase). (tuscany-diet.net)
  • A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol ring of caffeic acid esters in the presence of sodium benenesulfinate and sodium toluensulfinate as nucleophiles. (ac.ir)
  • PPO activity in unactivated MsPPO1-alfalfa extracts is sufficient to inhibit proteolysis in the presence of catechol, but not caffeic acid or (-)-epicatechin. (usda.gov)
  • Caffeic acid also shows immunomodulatory and anti-inflammatory activity. (wikipedia.org)
  • Although caffeic acid did slow tumor growth, it was less effective than two other substances, chlorogenic acid and ferulic acid. (medicalnewstoday.com)
  • High Performance Thin Layer Chromatography (HPTLC) was used for the quantification of the BCAD, amino acids were determined by High Performance Liquid Chromatography (HPLC) and a histochemical technique was used to study the physical structure of the plants. (ajol.info)
  • The reaction of caffeic acid with tryptophan was studied as a model for the reaction of caffeic acid with amino acids in the aquatic environment. (wmich.edu)
  • It is the precursor to ferulic acid, coniferyl alcohol, and sinapyl alcohol, all of which are significant building blocks in lignin. (wikipedia.org)
  • Some studies revealed that aside from chlorogenic acid, honeysuckle also contains other phenylpropanoids, such as flavones, isochlorogenic acid A, caffeic acid , lignin, and so on. (thefreedictionary.com)
  • Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis. (greenmedinfo.com)
  • Caffeic acid (CA) and ellagic acid (EA) are phenolic acids naturally occurring in many plant foods. (biomedcentral.com)
  • However, the information regarding the accumulation of caffeic acid or ellagic acid in cardiac tissue after dietary supplement is lacked. (biomedcentral.com)
  • 2009) due to presence of several other bioactive components like sitosterol, uracil, stigmasterol, quercetin, caffeic acid , ferulic acid, procatechuric acid and isorhamnetic (Lee et al. (thefreedictionary.com)
  • CA, an alkaloid, is adjudged world's most consumed food bioactive substance, while CAF is a common phenolic acid in plants. (deepdyve.com)
  • Caffeic acid is one of anti-oxidant phenolic acids and is abundant in plants and algae. (e-ajbc.org)
  • Our results showed that caffeic phenethyl ester inhibits H. pylori-induced NF-kappaB and AP-1 DNA-binding activity in a dose (0.1-25 microg ml(-1) approximately 0.35-88 microM) and time- (15-240 min) dependent manner in AGS cells. (tcd.ie)
  • Inhibits sterol fatty acid biosynthesis. (fishersci.com)
  • Various reports have shown that caffeic acid inhibits ultraviolet (UV)-induced matrix metalloproteinase 1 upregulation and skin carcinogenesis, however, the photoprotective effects on human follicle dermal papilla cells (HFDPCs) have not been elucidated yet. (e-ajbc.org)
  • We investigated if caffeic acid inhibits UV-induced cellular damages in HFDPCs by conducting cell viability, UV protection, intracellular reactive oxygen species (ROS), and cellular senescence detection assays. (e-ajbc.org)
  • Studies of the carcinogenicity of caffeic acid have mixed results. (wikipedia.org)
  • Caffeic acid is a substance that is present in all plants, including vegetables, fruits, herbs, coffee beans, plant-based spices and others that we eat and drink. (medicalnewstoday.com)
  • Data on the absorption of caffeic acid in humans is lacking. (nutrientjournal.com)
  • Therefore, Olthof and others [3] evaluated absorption of caffeic acid in cross-over study. (nutrientjournal.com)
  • Glutathione and thiol compounds (cysteine, thioglycolic acid or thiocresol) or ascorbic acid have a protective effect on browning and disappearance of caffeic acid. (wikipedia.org)
  • Our data indicated that caffeic acid has protective effects against UVB-induced cellular damages on HFDPCs. (e-ajbc.org)
  • It is the ester of caffeic acid and phenethyl alcohol. (wikipedia.org)
  • Caffeic acid inhibited non-small-cell lung cancer cell growth by inducing apoptosis. (greenmedinfo.com)
  • Furthermore, UVB-induced cellular senescence, which was detected by a senescence-associated β-galactosidase (SA-β-galactosidase) assay, markedly reduced in caffeic acid treatment before UVB irradiation on HFDPCs. (e-ajbc.org)
  • Whilst being hardly found in other edible plants, caffeoylisocitric acid represents the most abundant low molecular phenolic compound in many leafy amaranth species. (elsevier.com)
  • Caffeic acid is part of a group of chemicals called hydroxycinnamic acids . (medicalnewstoday.com)
  • What are hydroxycinnamic acids? (tuscany-diet.net)
  • Hydroxycinnamic acids are not present in high quantities since they are rapidly converted to glucose esters or coenzyme A (CoA) esters, in reactions catalyzed by O -glucosyltransferases and hydroxycinnamate:CoA ligases, respectively. (tuscany-diet.net)
  • Conversely, amino acid concentrations were significantly greater for greenhouse grown plants compared with outdoor grown plants. (ajol.info)
  • The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenicacid increase vitamin e and cholesterol concentrations in Sprague-Dawleyrats. (diva-portal.org)
  • Dietary polyphenol caffeic acid ( 1 ) has been reported for various pharmacological activities. (springermedizin.de)
  • It is the most abundant hydroxycinnamic acid in cereals, which are also its main dietary source. (tuscany-diet.net)
  • Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid', Iranian Journal of Pharmaceutical Research , 12(4), pp. 705-719. (ac.ir)
  • This hydroxylation produces the caffeic acid ester of shikimic acid, which converts to chlorogenic acid. (wikipedia.org)
  • The property of the anti inflammatory in the calendula makes it important in herbal medicines , the linoleic acid present in it give it a property of the anti inflammation and at the same time in anti fungal , which reduces the pains or any infections on the skin of the body, it is also edible which can reduce your internal fungal infections or any sort of inflammation within the body. (ayurvediccure.com)
  • The ulcers or gastritis can be treated through the calendula plants, the unsaturated fatty acids are responsible for the property of the anti inflammation of the calendula which helps in the reduction of the pain and burning sensation within the body [ 4 ]. (ayurvediccure.com)