A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.
A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).
Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.
An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)
Cinnamates are organic compounds that contain a cinnamic acid moiety, widely used in pharmaceutical and cosmetic industries as esters, with various applications ranging from UV absorbers to local anesthetics and antimicrobial agents.
A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
Phenolic benzoic acid esters.
Picrates are salts of picric acid, an explosive organic compound previously used as a yellow dye and antiseptic, which are now primarily used in chemical research and industrial applications. Please note that picrates should be handled with care due to their potential explosiveness when heated or subjected to friction.
A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.
A plant species of the genus IPOMOEA, family CONVOLVULACEAE. Some cultivars are sweet and edible whereas bitter varieties are a source of SAPONINS. This sweet potato is sometimes referred to as a yam (DIOSCOREA).
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A large class of organic compounds having more than one PHENOL group.
A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.
Phenylpropionates are a class of organic compounds, including certain drugs such as ephedrine and pseudoephedrine, which contain a phenylethanoic acid structure with a propionate substitution.
Glucosides are glycosides that contain glucose as the sugar component, often forming part of the plant's defense mechanism and can have various pharmacological effects when extracted and used medically.
A genus of perennial herbs used topically and internally. It contains echinacoside, GLYCOSIDES; INULIN; isobutyl amides, resin, and SESQUITERPENES.
A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A plant genus of the family ASTERACEAE. Ingestion has been associated with MILK SICKNESS. The common name of thoroughwort is also used for other plants including CHROMOLAENA; Hebeclinium, and Koanophyllon.
A plant species of the Salvia genus known as a spice and medicinal plant.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (1/401)

The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. Substrates containing a -COOH group are inhibitors for catechol oxidase. The products of enzymic oxidation of caffeic acid were analyzed and isolated by HPLC with diode array detection. The neolignans of the 2,3-dihydro-1,4-benzodioxin type (3, 6-8), 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-2,3-dicarboxy-1,2-dihydro naphthaline (1) 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-3-carboxynaphthaline (5) and 2,6-bis-(3',4'-dihydroxyphenyl)-1-carboxy-3-oxacyclo-(3,0)-pent an-2-on-1-ene (4) were formed. A reaction mechanism for the formation of (1, 4 and 5) is discussed.  (+info)

Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase. (2/401)

In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and dopa decarboxylase and showed hypotensive activity in the SH rat.  (+info)

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. (3/401)

We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 microg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediated induction of PGE2 synthesis. This relatively low concentration of CAPE did not affect amounts of cyclooxygenase (COX) enzymes. CAPE nonselectively inhibited the activities of baculovirus-expressed hCOX-1 and hCOX-2 enzymes. TPA- and A23187-stimulated release of arachidonic acid from membrane phospholipids was also suppressed by CAPE (4-8 microg/ml). Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA. Transient transfections using human COX-2 promoter deletion constructs were performed; the effects of TPA and CAPE were localized to a 124-bp region of the COX-2 promoter. In the rat carrageenan air pouch model of inflammation, CAPE (10-100 mg/kg) caused dose-dependent suppression of PG synthesis. Amounts of COX-2 in the pouch were markedly suppressed by 100 mg/kg CAPE but were unaffected by indomethacin. These data are important for understanding the anticancer and anti-inflammatory properties of CAPE.  (+info)

Genetic analysis of a chromosomal region containing vanA and vanB, genes required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter. (4/401)

VanA and VanB form an oxygenative demethylase that converts vanillate to protocatechuate in microorganisms. Ferulate, an abundant phytochemical, had been shown to be metabolized through a vanillate intermediate in several Pseudomonas isolates, and biochemical evidence had indicated that vanillate also is an intermediate in ferulate catabolism by Acinetobacter. Genetic evidence supporting this conclusion was obtained by characterization of mutant Acinetobacter strains blocked in catabolism of both ferulate and vanillate. Cloned Acinetobacter vanA and vanB were shown to be members of a chromosomal segment remote from a supraoperonic cluster containing other genes required for completion of the catabolism of ferulate and its structural analogs, caffeate and coumarate, through protocatechuate. The nucleotide sequence of DNA containing vanA and vanB demonstrated the presence of genes that, on the basis of nucleotide sequence similarity, appeared to be associated with transport of aromatic compounds, metabolism of such compounds, or iron scavenging. Spontaneous deletion of 100 kb of DNA containing this segment does not impede the growth of cells with simple carbon sources other than vanillate or ferulate. Additional spontaneous mutations blocking vanA and vanB expression were shown to be mediated by IS1236, including insertion of the newly discovered composite transposon Tn5613. On the whole, vanA and vanB appear to be located within a nonessential genetic region that exhibits considerable genetic malleability in Acinetobacter. The overall organization of genes neighboring Acinetobacter vanA and vanB, including a putative transcriptional regulatory gene that is convergently transcribed and overlaps vanB, is conserved in Pseudomonas aeruginosa but has undergone radical rearrangement in other Pseudomonas species.  (+info)

The rabbit lens epithelial cell line N/N1003A requires 12-lipoxygenase activity for DNA synthesis in response to EGF. (5/401)

PURPOSE: Cultured rat lenses and primary human lens epithelial cells (HLECs) express12-lipoxygenase (12-LOX) and require a 12-LOX metabolite of arachidonic acid for growth in response to EGF and insulin. This study seeks to identify an established cell line with these characteristics. METHODS: Immunoblotting was used to screen eight lens epithelial cell lines for 12-LOX expression: the human line, HLE-B3; mouse lines alphaTN4, 17EM15, 21EM15, and MLE6, and rabbit lines N/N1003A, LEP2 and B3. DNA synthesis was measured as incorporation of 3H-thymidine into DNA. Expression of c-fos mRNA was detected by RT-PCR. The involvement of 12-lipoxygenase metabolites was determined using the lipoxygenase inhibitors baicalein, cinnamyl 3,4-dihydroxy-alpha-cyanocinnamate (CDC), or nordihydroguiairetic acid (NDGA). RESULTS: 12-LOX was detected only in the rabbit lines N/N1003A, LEP2 and B3. N/N1003A cells were chosen for further study. 12-LOX inhibitors blocked DNA synthesis in response to EGF with or without insulin. Inhibition of EGF-stimulated DNA synthesis was reversed by 0.3 microM to 3 microM 12(S)hydroxyeicosatetraenoic acid (HETE), but not by equivalent concentrations of 5(S)HETE, 8(S)HETE, 15(S)HETE, or 12(R)HETE. Baicalein prevented EGF induction of c-fos mRNA. The transformed HLEC line, HLE-B3, showed little stimulation of DNA synthesis in response to EGF and was unaffected by the presence of 12-LOX inhibitors. CONCLUSIONS: N/N1003A cells, like primary cultured human lens epithelial cells or neonatal rat lenses, require 12-LOX activity for EGF dependent growth. This line will be useful for studies of the mechanism of action of 12(S)HETE.  (+info)

An early salicylic acid-, pathogen- and elicitor-inducible tobacco glucosyltransferase: role in compartmentalization of phenolics and H2O2 metabolism. (6/401)

Treatment of tobacco cell suspension cultures with a fungal elicitor of defense responses resulted in an early accumulation of the phenylpropanoid glucosyltransferase TOGT, along with the rapid synthesis and secretion of scopolin, the glucoside of scopoletin. Elicitor-triggered extracellular accumulation of the aglycone scopoletin and of free caffeic and ferulic acids could only be revealed in the presence of diphenylene iodonium, an inhibitor of extracellular H2O2 production. Our results strongly support a role for TOGT in the elicitor-stimulated production of transportable phenylpropanoid glucosides, followed by the release of free antioxidant phenolics into the extracellular medium and subsequent H2O2 scavenging.  (+info)

The small intestine can both absorb and glucuronidate luminal flavonoids. (7/401)

We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.  (+info)

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. (8/401)

The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents. Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in cell proliferation and survival. In this study, we investigated the potential role of AA as a proapoptotic agent in CML. Pretreatment of human CML isolated progenitor cells with AA (100 microM for 18 h) induced 71-75% inhibition of in vitro colony formation of granulocyte-macrophage colony-forming units, multilineage colony-forming units, and erythroid burst-forming units. This inhibition was significantly greater than the effect on normal progenitor cells (19-39% growth inhibition of erythroid burst-forming units, multilineage colony-forming units, and granulocyte-macrophage colony-forming units). AA also inhibited growth of the bcr-abl-transformed cell line H7.bcr-abl A54. In contrast, a minimal effect of AA on inhibition of cell growth was observed in the parental nontransformed NSF/N1.H7 cell line. The antiproliferative effect of AA was associated with apoptosis. Gamma-linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no effect. Pharmacological inhibition of cyclooxygenase, lipooxygenase, and cytochrome P450 monooxygenase enzymes prior to exposure to AA did not rescue cells from the inhibitory effect of AA. Moreover, 5,8,11,14-eicosatetraynoic acid, a nonmetabolizable arachidonate analogue, also inhibited cell growth, suggesting that the effect of AA did not require further metabolism. Treatment with antioxidants prior to stimulation with AA was also ineffective in preventing its antiproliferative effect. Thus, AA inhibited proliferation of CML cells by inducing apoptotic cell death. The signaling mechanisms of AA-induced inhibition of cell growth appeared to be independent of its conversion into eicosanoids or free radical generation.  (+info)

Caffeic acids are a type of phenolic compounds that contain a catechol structure and a carboxylic acid group. They are found in various plants, including coffee, tea, fruits, and vegetables. The most common caffeic acid is caffeic acid itself, which is abundant in coffee. Caffeic acids have been studied for their potential health benefits, such as antioxidant, anti-inflammatory, and anticancer activities. However, more research is needed to fully understand their effects on human health.

Chlorogenic acid is a type of polyphenolic compound that is found in various plants, including coffee, tea, and several fruits and vegetables. It is a ester of cinnamic acid and quinic acid. Chlorogenic acids are known to have antioxidant properties and may also play a role in regulating glucose metabolism and inhibiting the growth of certain types of cancer cells. However, more research is needed to fully understand the potential health benefits and risks associated with chlorogenic acid consumption.

Coumaric acids are a type of phenolic acid that are widely distributed in plants. They are found in various foods such as fruits, vegetables, and grains. The most common forms of coumaric acids are p-coumaric acid, o-coumaric acid, and m-coumaric acid.

Coumaric acids have been studied for their potential health benefits, including their antioxidant, anti-inflammatory, and antimicrobial properties. They may also play a role in preventing chronic diseases such as cancer and cardiovascular disease. However, more research is needed to fully understand the potential health benefits of coumaric acids.

It's worth noting that coumaric acids are not to be confused with warfarin (also known as Coumadin), a medication used as an anticoagulant. While both coumaric acids and warfarin contain a similar chemical structure, they have different effects on the body.

Phenylethyl Alcohol is not a medical term per se, but it is a chemical compound with the formula C8H10O. It is a colorless oily liquid that is used as a fragrance ingredient in cosmetics and personal care products due to its rose-like odor.

In a medical context, Phenylethyl Alcohol may be mentioned in relation to its potential antimicrobial properties or as a component of certain pharmaceutical preparations. However, it is not a medication or treatment on its own. It is important to note that while Phenylethyl Alcohol has been studied for its potential health benefits, more research is needed before any definitive conclusions can be drawn.

Quinic acid is not typically defined in a medical context, but rather it is an organic compound that is widely found in nature. It's a type of chemical called a hydroxyacid, and it's particularly abundant in plants. Quinic acid is a white crystalline solid at room temperature and has a slightly sweet taste.

In the medical field, quinic acid may be mentioned in relation to certain medical conditions or treatments. For example, quinic acid is one of the compounds found in large quantities in tea, coffee, and some fruits, and it has been studied for its potential antioxidant properties. Additionally, quinic acid is a metabolic intermediate in the synthesis of various substances in the body, including certain amino acids and neurotransmitters.

However, it's important to note that quinic acid itself is not typically used as a medication or treatment for any medical conditions.

Cinnamates are organic compounds that are derived from cinnamic acid. They contain a carbon ring with a double bond and a carboxylic acid group, making them aromatic acids. Cinnamates are widely used in the perfume industry due to their pleasant odor, and they also have various applications in the pharmaceutical and chemical industries.

In a medical context, cinnamates may be used as topical medications for the treatment of skin conditions such as fungal infections or inflammation. For example, cinnamate esters such as cinoxacin and ciclopirox are commonly used as antifungal agents in creams, lotions, and shampoos. These compounds work by disrupting the cell membranes of fungi, leading to their death.

Cinnamates may also have potential therapeutic benefits for other medical conditions. For instance, some studies suggest that cinnamate derivatives may have anti-inflammatory, antioxidant, and neuroprotective properties, making them promising candidates for the development of new drugs to treat diseases such as Alzheimer's and Parkinson's. However, more research is needed to confirm these effects and determine their safety and efficacy in humans.

Propolis is a resinous substance that honeybees collect from tree buds, sap flows, or other botanical sources. They use it to seal gaps and holes in their hives as a protective barrier against external threats such as intruders (like other insects) and harsh weather conditions. Propolis has been found to have various chemical compositions depending on the plant sources, but it primarily consists of flavonoids, phenolic acids, and esters, which contribute to its biological activities. It has been used in traditional medicine for centuries due to its potential health benefits, including antimicrobial, anti-inflammatory, antioxidant, and wound-healing properties; however, more scientific research is needed to confirm these effects and establish safe and effective therapeutic dosages.

Hydroxybenzoates are the salts or esters of hydroxybenzoic acids. They are commonly used as preservatives in food, cosmetics, and pharmaceutical products due to their antimicrobial and antifungal properties. The most common examples include methylparaben, ethylparaben, propylparaben, and butylparaben. These compounds work by inhibiting the growth of bacteria and fungi, thereby increasing the shelf life and safety of various products. However, there has been some concern about their potential health effects, including possible hormonal disruption, and their use in certain applications is being re-evaluated.

I'm sorry for any confusion, but "Lignin" is not a medical term. It is a term used in the field of biology and chemistry, particularly in botany and wood science. Lignin is a complex organic polymer that binds cellulose fibers together, providing strength and rigidity to the cell walls of plants. It is a major component of wood and bark.

If you have any medical terms you would like defined or any other questions, please let me know!

Phenols, also known as phenolic acids or phenol derivatives, are a class of chemical compounds consisting of a hydroxyl group (-OH) attached to an aromatic hydrocarbon ring. In the context of medicine and biology, phenols are often referred to as a type of antioxidant that can be found in various foods and plants.

Phenols have the ability to neutralize free radicals, which are unstable molecules that can cause damage to cells and contribute to the development of chronic diseases such as cancer, heart disease, and neurodegenerative disorders. Some common examples of phenolic compounds include gallic acid, caffeic acid, ferulic acid, and ellagic acid, among many others.

Phenols can also have various pharmacological activities, including anti-inflammatory, antimicrobial, and analgesic effects. However, some phenolic compounds can also be toxic or irritating to the body in high concentrations, so their use as therapeutic agents must be carefully monitored and controlled.

I apologize for the confusion, but "Lamiaceae" is not a medical term. It is a taxonomic category in biology, specifically it is a family of flowering plants that includes many familiar herbs such as mint, rosemary, sage, basil, and lavender. These plants are often used in medicine, cooking, and for ornamental purposes. The Lamiaceae family is characterized by their square stems, opposite leaves, and two-lipped flowers.

Rutin is a flavonoid, a type of plant pigment that is found in various plants and foods including citrus fruits, buckwheat, and asparagus. It has antioxidant properties and is known to help strengthen blood vessels and reduce inflammation. In medical terms, rutin may be mentioned in the context of discussing treatments for conditions related to these effects, such as varicose veins or hemorrhoids. However, it's important to note that while rutin has potential health benefits, more research is needed to fully understand its effects and proper dosages.

Depsides are a type of chemical compound that are formed by the condensation of two molecules of phenolic acids. They are a subclass of polyphenols, which are compounds found in plants that have various biological activities. Depsides are characterized by the presence of a central core structure consisting of a benzene ring linked to a carboxylic acid group through a carbon-carbon bond.

Depsides can be further classified into different subgroups based on the specific phenolic acids that make up their structure. Some common examples of depsides include chlorogenic acid, which is formed from caffeic acid and quinic acid, and rosmarinic acid, which is formed from caffeic acid and 3,4-dihydroxyphenyllactic acid.

Depsides have been studied for their potential health benefits, including antioxidant, anti-inflammatory, and antimicrobial activities. They are found in a variety of plant foods, such as fruits, vegetables, herbs, and spices, and may contribute to the overall health-promoting properties of these foods.

I am not a medical expert, but I can provide some information that may be helpful. "Picrates" is not a term commonly used in medical definitions. Instead, it is a term used in chemistry to refer to salts of picric acid (2,4,6-trinitrophenol), which was once used as a yellow dye and explosive.

Picric acid has been used historically in some medical applications, such as a component in certain topical antiseptics and in histological staining procedures. However, its use in modern medicine is quite limited due to its high sensitivity to impact, heat, and friction, which makes it potentially dangerous to handle.

Therefore, it's important to note that "picrates" is not a medical term per se but rather a chemical one, and any medical application of picric acid or its salts would be highly specialized and unlikely to be encountered in most healthcare settings.

"Lonicera" is a genus of shrubs and climbers commonly known as honeysuckles. It does not have a specific medical definition, but some species of Lonicera are used in traditional medicine in various cultures. For example, Lonicera japonica (Japanese honeysuckle) is used in Traditional Chinese Medicine for its anti-inflammatory, antibacterial, and antiviral properties. However, it's important to note that the use of these plants as medicine should be under the guidance of a healthcare professional, as they can also have side effects and interact with other medications.

'Ipomoea batatas' is the scientific name for a plant species, commonly known as sweet potato. It is a starchy, root vegetable that comes in various colors and sizes. While I am primarily designed to answer legal, financial, and business questions, I can provide general information about various topics. However, for medical advice or information, it is always best to consult with a healthcare professional.

Catechols are a type of chemical compound that contain a benzene ring with two hydroxyl groups (-OH) attached to it in the ortho position. The term "catechol" is often used interchangeably with "ortho-dihydroxybenzene." Catechols are important in biology because they are produced through the metabolism of certain amino acids, such as phenylalanine and tyrosine, and are involved in the synthesis of various neurotransmitters and hormones. They also have antioxidant properties and can act as reducing agents. In chemistry, catechols can undergo various reactions, such as oxidation and polymerization, to form other classes of compounds.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, which are unstable molecules that the body produces as a reaction to environmental and other pressures. Antioxidants are able to neutralize free radicals by donating an electron to them, thus stabilizing them and preventing them from causing further damage to the cells.

Antioxidants can be found in a variety of foods, including fruits, vegetables, nuts, and grains. Some common antioxidants include vitamins C and E, beta-carotene, and selenium. Antioxidants are also available as dietary supplements.

In addition to their role in protecting cells from damage, antioxidants have been studied for their potential to prevent or treat a number of health conditions, including cancer, heart disease, and age-related macular degeneration. However, more research is needed to fully understand the potential benefits and risks of using antioxidant supplements.

Polyphenols are a type of phytochemical, which are naturally occurring compounds found in plant-based foods. They contain multiple phenol units and can be classified into several subgroups, including flavonoids, stilbenes, tannins, and lignans. These compounds have been studied for their potential health benefits due to their antioxidant, anti-inflammatory, and immune-modulating properties. They are found in a wide variety of foods such as fruits, vegetables, tea, wine, chocolate, and cereals.

Coffee is defined in medical terms as a beverage prepared from the roasted seeds of the Coffea plant. It contains caffeine, a stimulant that can help increase alertness, improve mood, and boost mental and physical performance. Coffee also contains antioxidants and other bioactive compounds that may have health benefits. However, excessive consumption of coffee can lead to side effects such as insomnia, nervousness, restlessness, and rapid heart rate. It's important to consume coffee in moderation and be aware of its potential interactions with medications and medical conditions.

Phenylpropionates are a group of organic compounds that contain a phenyl group and a propionate group. In the context of pharmaceuticals, phenylpropionates often refer to a specific type of esterified hormone, such as testosterone phenylpropionate or nandrolone phenylpropionate. These esters are used in some forms of anabolic-androgenic steroids and are created by attaching a phenylpropionate group to the parent hormone molecule. This modification allows for a slower release and longer duration of action when administered intramuscularly.

It is important to note that these substances have medical uses, but they also carry risks and potential side effects, especially when used inappropriately or without medical supervision. They are controlled substances in many countries due to their potential for misuse and abuse.

Glucosides are chemical compounds that consist of a glycosidic bond between a sugar molecule (typically glucose) and another non-sugar molecule, which can be an alcohol, phenol, or steroid. They occur naturally in various plants and some microorganisms.

Glucosides are not medical terms per se, but they do have significance in pharmacology and toxicology because some of them may release the sugar portion upon hydrolysis, yielding aglycone, which can have physiological effects when ingested or absorbed into the body. Some glucosides are used as medications or dietary supplements due to their therapeutic properties, while others can be toxic if consumed in large quantities.

Echinacea is a type of herb that is native to North America. It is also known as the purple coneflower and is used in herbal medicine for its alleged ability to boost the immune system and help fight off colds and other infections. The active ingredients in echinacea are thought to be compounds called alkylamides, which may have anti-inflammatory and immune-stimulating effects.

There is some evidence to suggest that echinacea may help reduce the duration and severity of colds when taken at the onset of symptoms, but the overall body of research on its effectiveness is mixed. Some studies have found no significant benefit, while others have reported modest reductions in the length and severity of cold symptoms.

Echinacea is generally considered to be safe when used as directed, but it can cause side effects such as stomach upset, headache, and dizziness in some people. It may also interact with certain medications, so it is important to speak with a healthcare provider before taking echinacea if you are taking any prescription drugs or have any underlying health conditions.

Rhodobacter is not a medical term, but a genus of bacteria found in the environment. It is commonly found in aquatic environments and can perform photosynthesis, although it is not classified as a plant. Some species of Rhodobacter are capable of fixing nitrogen gas from the atmosphere, making them important contributors to the global nitrogen cycle.

While there may be some medical research into the potential uses or impacts of certain species of Rhodobacter, there is no widely recognized medical definition for this term. If you have any specific concerns about bacteria or infections, it's best to consult with a healthcare professional for accurate information and advice.

Free radical scavengers, also known as antioxidants, are substances that neutralize or stabilize free radicals. Free radicals are highly reactive atoms or molecules with unpaired electrons, capable of causing damage to cells and tissues in the body through a process called oxidative stress. Antioxidants donate an electron to the free radical, thereby neutralizing it and preventing it from causing further damage. They can be found naturally in foods such as fruits, vegetables, and nuts, or they can be synthesized and used as dietary supplements. Examples of antioxidants include vitamins C and E, beta-carotene, and selenium.

Catechol oxidase, also known as polyphenol oxidase, is an enzyme that catalyzes the oxidation of catechols and other phenolic compounds to quinones. These quinones can then undergo further reactions to form various pigmented compounds, such as melanins. Catechol oxidase is widely distributed in nature and is found in plants, fungi, and some bacteria. In humans, catechol oxidase is involved in the metabolism of neurotransmitters such as dopamine and epinephrine.

I'm sorry for any confusion, but "honey" is not typically considered a medical term. It is a natural sweet substance produced by honeybees from the nectar of flowers. Honey is composed primarily of fructose and glucose, with small amounts of other sugars, water, proteins, amino acids, vitamins, minerals, enzymes, and various organic compounds.

While honey does have some potential health benefits, such as its antimicrobial properties and its use in wound healing, it is not a medical treatment or intervention. If you have any questions about the medicinal uses of honey or its role in health, I would recommend consulting with a healthcare professional.

Methyltransferases are a class of enzymes that catalyze the transfer of a methyl group (-CH3) from a donor molecule to an acceptor molecule, which is often a protein, DNA, or RNA. This transfer of a methyl group can modify the chemical and physical properties of the acceptor molecule, playing a crucial role in various cellular processes such as gene expression, signal transduction, and DNA repair.

In biochemistry, methyltransferases are classified based on the type of donor molecule they use for the transfer of the methyl group. The most common methyl donor is S-adenosylmethionine (SAM), a universal methyl group donor found in many organisms. Methyltransferases that utilize SAM as a cofactor are called SAM-dependent methyltransferases.

Abnormal regulation or function of methyltransferases has been implicated in several diseases, including cancer and neurological disorders. Therefore, understanding the structure, function, and regulation of these enzymes is essential for developing targeted therapies to treat these conditions.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

"Eupatorium" is a genus of flowering plants in the family Asteraceae, also known as the daisy family. These plants are native to North America and are commonly known as Joe-Pye weeds or thoroughworts. Some species of Eupatorium have been used in traditional medicine for their alleged healing properties, although there is limited scientific evidence to support these claims. It's important to note that some Eupatorium species can contain toxic compounds and should not be ingested without proper medical supervision.

'Salvia officinalis', also known as garden sage or common sage, is not a medical condition but an herb that has been used in traditional medicine. Here's the botanical definition:

Salvia officinalis, commonly known as sage, garden sage, or common sage, is a perennial, evergreen subshrub, with woody stems, grayish leaves, and blue to purplish flowers. It belongs to the Lamiaceae family, also known as the mint family. The plant is native to the Mediterranean region and has been cultivated throughout the world for its aromatic leaves, which are used in cooking, cosmetics, and medicinal preparations.

In traditional medicine, sage leaves have been used to treat various conditions, such as sore throats, coughs, colds, and digestive issues. However, it is essential to note that the effectiveness of sage for these uses has not been thoroughly studied in clinical trials, and its use should not replace conventional medical care. Always consult with a healthcare professional before starting any new treatment or therapy.

High-performance liquid chromatography (HPLC) is a type of chromatography that separates and analyzes compounds based on their interactions with a stationary phase and a mobile phase under high pressure. The mobile phase, which can be a gas or liquid, carries the sample mixture through a column containing the stationary phase.

In HPLC, the mobile phase is a liquid, and it is pumped through the column at high pressures (up to several hundred atmospheres) to achieve faster separation times and better resolution than other types of liquid chromatography. The stationary phase can be a solid or a liquid supported on a solid, and it interacts differently with each component in the sample mixture, causing them to separate as they travel through the column.

HPLC is widely used in analytical chemistry, pharmaceuticals, biotechnology, and other fields to separate, identify, and quantify compounds present in complex mixtures. It can be used to analyze a wide range of substances, including drugs, hormones, vitamins, pigments, flavors, and pollutants. HPLC is also used in the preparation of pure samples for further study or use.

  • Caffeic acid and its derivative caffeic acid phenethyl ester (CAPE) are produced in many kinds of plants. (wikipedia.org)
  • A novel antioxidant agent caffeic acid phenethyl ester prevents long-term mobile phone exposure-induced renal impairment in rat. (emf-portal.org)
  • Dziedzic A, Kubina R, Kabała-Dzik A, Tanasiewicz M. Induction of cell cycle arrest and apoptotic response of head and neck squamous carcinoma cells (detroit 562) by caffeic acid and caffeic acid phenethyl ester derivative. (inabj.org)
  • An active component of honeybee hives, CAPE (Caffeic Acid Phenethyl Ester), is believed to inhibit inflammatory process via the inhibition of NFκB activation. (ub.ac.id)
  • Caffeic Acid Phenethyl Ester is A Potent and Specific Inhibitor of Activation of Nuclear Transcription Factor NF-kB.Proc. (ub.ac.id)
  • Anti-glioma effects of Caffeic acid phenethyl ester and Dasatinib combination therapy in an in vivo rat glioma model. (propolisscience.org)
  • Background: Caffeic acid phenethyl ester and Dasatinib in combination, when used in congruous proportions and durations, present an antitumor potential for glioma in vitro, suggesting a high therapeutic potential for glioma treatment. (propolisscience.org)
  • In this study, we found that caffeic acid phenethyl ester (CAPE) displayed an inhibitory effect on human coronary smooth muscle cell (HCSMC) growth and migration. (cellmolbiol.org)
  • Caffeic acid phenethyl ester human coronary smooth muscle cells proliferation migration restenosis local delivery cell cycle. (cellmolbiol.org)
  • Caffeic Acid Phenethyl Ester (CAPE), an antioxidant flavonoid isolated from hives of honeybee, is reported to exert its anti-osteogenic function by inhibiting the NF-kB activation. (pcom.edu)
  • Caffeic Acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines. (propolisscience.org)
  • We evaluated the in vitro cytotoxic activity of ethanol extract of propolis (EEP) and its derivative caffeic acid phenethyl ester (CAPE) towards two triple-negative breast cancer (TNBC) cell lines, MDA-MB-231 and Hs578T, by implementation of the MTT and lactate dehydrogenase (LDH) assays. (propolisscience.org)
  • This study investigated the protective effects of caffeic acid phenethyl ester (CAPE) against rifampicin-isoniazid-induced hepatic and pancreatictoxicity in terms of histopathological deterioration, oxidative stress (paraoxonase-1, total antioxidant status, total oxidant status) and biochemical parameters changes. (uwi.edu)
  • To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage. (uwi.edu)
  • The aim of this study was to investigate whether propolis and caffeic acid phenethyl ester (CAPE) prevent radiation-induced cataractogenesis. (uwi.edu)
  • NFkB activation was associated with TNF-alpha production, since the cells pre-treated with a known NFkB inhibitor (caffeic acid phenethyl ester) decreased both NFkB activation and TNF-alpha production. (cdc.gov)
  • Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid (esterified through a side chain alcohol). (wikipedia.org)
  • This hydroxylation produces the caffeic acid ester of shikimic acid, which converts to chlorogenic acid. (wikipedia.org)
  • Although caffeic acid did slow tumor growth, it was less effective than the other two substances, chlorogenic acid and ferulic acid. (zhenyibio.com)
  • Different purity levels of caffeic acid can affect pricing.Higher purity products, which require more stringent manufacturing and testing processes, may be priced higher. (hzfoodic.com)
  • Most studies have found that caffeic acid can slow or reverse inflammation. (zhenyibio.com)
  • Studies have also found that caffeic acid is safe, even in relatively large doses. (zhenyibio.com)
  • The study found that caffeic acid can target a chemical that helps specific types of breast cancer cells multiply. (zhenyibio.com)
  • A 1996 study found that caffeic acid can target specific sources of inflammation, both in petri dishes and in humans. (zhenyibio.com)
  • Diabetes: Studies in mice have found that caffeic acid can counteract some of the effects of diabetes. (zhenyibio.com)
  • A 2009 study of diabetic mice found that caffeic acid can raise insulin levels in the blood, lower blood sugar and fight inflammation. (zhenyibio.com)
  • The scientists, from the University of Texas at El Paso (UTEP), found that caffeic-acid-based Carbon Quantum Dots (CACQDs), which are easily obtained from spent coffee grounds, have the potential to protect brain cells from damage caused by several NDs if the condition is triggered by factors such as obesity, age and exposure to pesticides and other toxic environmental chemicals. (gazettelive.co.uk)
  • Caffeic acid is an antioxidant in vitro and also in vivo. (wikipedia.org)
  • Caffeic acid is thought to have potential anti-inflammatory and antioxidant properties. (zhenyibio.com)
  • Like many other polyphenols, caffeic acid is an antioxidant. (zhenyibio.com)
  • Some skin and body care companies add caffeic acid to their products because of its antioxidant properties. (zhenyibio.com)
  • Caffeic acid (3,4-dihydroxy-cinnamic acid) waa unug dabiici ah iyo antioxidant awood leh. (wisepowder.com)
  • Caffeic aashitada waxaa loo maleynayaa inay leedahay saameyn badan ee jirka oo ay ku jiraan antioxidant iyo saamaynta anti-bararka. (wisepowder.com)
  • It is well documented that out of several bioactive compounds, caffeic acid (CA) is the most significant antioxidant rich phenolic component that widely distributed as hydroxylcinnamate and phenylpropanoid metabolites consisting of both phenolic and acrylic functional groups [ 5 ]. (biomedcentral.com)
  • The phenolic compounds catechin and caffeic acid that occur in white wine and have antioxidant effects, are also quantified in the same analysis. (unimi.it)
  • Girsang E, Lister INE, Ginting CN, Bethasari M, Amalia A, Widowati W. Comparison of antiaging and antioxidant activities of protocatechuic and ferulic acids. (inabj.org)
  • Natural antioxidants caffeic acid (CA), rosmarinic acid (RA), trans cinnamic acid (TCA), p-coumaric acid (PCA), and hydroxyphenyllactic acid (HPA) acid are known to be potent anticancer and antioxidant agents. (elsevierpure.com)
  • Caffeic acid outperformed the other antioxidants, reducing aflatoxin production by more than 95 percent. (wikipedia.org)
  • In the same study, high doses of combined antioxidants, including caffeic acid, showed a significant decrease in growth of colon tumors in those same rats. (wikipedia.org)
  • Similar to other antioxidants, caffeic acid can also slow down the body's aging process. (zhenyibio.com)
  • This study aims to evaluate the chemopreventive activity of two antioxidants (curcumin [CUM] and caffeic acid [CAF]), focusing on how these antioxidants could reduce cytotoxicity induced by short term secondhand exposure of waterpipe tobacco smoking. (kyobobook.co.kr)
  • Additionally, a 2014 study showed that caffeic acid derivatives inhibited colon cancer cell growth both in vitro and in vivo. (zhenyibio.com)
  • Xaruntan phenolic waxaa laga helaa qaabka fudud ( monomers) sida esters acid organic, esters sonkorta, amides iyo glycosides, ama qaabab aad u adag sida dimers, trimers iyo flavonoid derivatives, ama waxay sidoo kale ku xiran yihiin borotiinno iyo polymers kale derbiga unugga ee khudradda. (wisepowder.com)
  • Based on this and also, on the facts that Taraxacum officinale L. contains a considerable amount of caffeic acid derivatives (48.8 mg/g in the leaves) and it does not exhibit a cytotoxic activity, we aimed to obtain a pharmacological active dry extract, titrated in cichoric acid, which can be developed in a pharmaceutical product used in type 2 diabetes mellitus therapy. (farmaciajournal.com)
  • The aim of this work was to optimize and evaluate the extraction parameters of caffeic acid derivatives from the plant material using Ultrasound - Assisted Extraction (UAE). (farmaciajournal.com)
  • The effects of different parameters of caffeic acid derivatives yields, in plants extracts were investigated using an experimental design - Taguchi L16 (45) orthogonal array design. (farmaciajournal.com)
  • An HPLC/UV method was employed for the qualitative and quantitative determination of caffeic acid derivatives from the liquid extracts and from the lyophilized extract. (farmaciajournal.com)
  • The amount of caffeic acid derivatives and cichoric acid in the dry extract was 127.0 mg/g and 107.50 mg/g. (farmaciajournal.com)
  • Yan, Y. & Lin, Y. Biosynthesis of caffeic acid and caffeic acid derivatives by recombinant microorganisms. (nature.com)
  • Hangzhou Biopak Co Ltd is known as manufactuer of Phenolic Acids/ Polyphenols manufacturer in China, all based on innovative biosynthesis production process, and our full controlled subsidiary company in Nanchang of Jiangxi Province, is a modern plant occupying an area of 40,000 sqm. (biochemicals.cn)
  • These aromatic acids are part of a larger group of chemicals called polyphenols. (zhenyibio.com)
  • It is the precursor to ferulic acid, coniferyl alcohol, and sinapyl alcohol, all of which are significant building blocks in lignin. (wikipedia.org)
  • The transformation to ferulic acid is catalyzed by the enzyme caffeate O-methyltransferase. (wikipedia.org)
  • Caffeate O-methyltransferase is an enzyme responsible for the transformation of caffeic acid into ferulic acid. (wikipedia.org)
  • Plasma levels of L-dopa, 3-O-methyldopa (3-OMD), caffeic acid, and ferulic acid were determined and subsequently used to calculate their pharmacokinetic parameters. (tmu.edu.tw)
  • In contrast, the parameters of neither caffeic acid nor ferulic acid were significantly affected by L-dopa/carbidopa. (tmu.edu.tw)
  • Wang T, Gong X, Jiang R, Li H, Du W, Kuang G. Ferulic acid inhibits proliferation and promotes apoptosis via blockage of PI3K/Akt pathway in osteosarcoma cell. (inabj.org)
  • Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo. (aaem.pl)
  • Caffeic Acid is a natural phenolic compound initially found in plants. (biochemicals.cn)
  • Previously, the neuroprotection of phenolic acids and flavonoids in the brain has been indicated. (aaem.pl)
  • This study measured anticholinesterase activities of 9 phenolic acids and 6 flavonoids, singly or in combination. (aaem.pl)
  • Caspase inhibitor diminishes caffeic acid-induced apoptosis in osteosarcoma cells. (inabj.org)
  • Caffeic acid (CA) waa polyphenol oo lagu soo saaro dheef-shiid kiimikaadka labaad ee khudaarta, oo ay ku jiraan saytuunka, digirta qaxwaha, miraha, baradhada, dabacasaha iyo propolis, waxayna ka kooban tahay hydroxycinnamic acid ugu weyn ee laga helo cuntada dadka. (wisepowder.com)
  • Consequently, this propolis underwent fractionation by chromatographic methods monitored through Agar-diffusion assays with these bacteria, which resulted in the isolation and identification of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C), which showed MIC of 62.5 and 250 µg/mL against B. subtilis and S. aureus, respectively. (scielo.br)
  • Caffeic acid has a variety of potential pharmacological effects in in vitro studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma cell line has recently been established. (wikipedia.org)
  • The ESTs sequences of caffeic acid O-methyltransferase from Larix kaempferi transcriptome database, an cDNA clone encoding COMT, was isolated from L. kaempferi by gene-specific PCR amplification. (lykxyj.com)
  • The sequence indicated that the deduced amino acid contained five highly conserved regions of COMT family, and shared 94% identity with PpCOMT from Pinus pinaster. (lykxyj.com)
  • In conclusion, caffeic acid at a dose of 10 mg·kg -1 can significantly affect the COMT metabolic pathway of L-dopa. (tmu.edu.tw)
  • Berries of Actinidia kolomikta ( A. kolomikta ) are known for high ascorbic acid content, but the diversity of phenolic compounds has been little studied. (mdpi.com)
  • Caffeic acid also shows immunomodulatory and anti-inflammatory activity. (wikipedia.org)
  • Chronic inflammation: The anti-inflammatory powers of caffeic acid are one way it may fight or prevent cancer. (zhenyibio.com)
  • Oral administration of high doses of caffeic acid in rats has caused stomach papillomas. (wikipedia.org)
  • A single dose of 5/1.25 mg·kg -1 L-dopa/carbidopa was administered alone or was coadministered with three different doses of caffeic acid (2.5, 5, and 10 mg·kg -1 ), or a single dose of 5 mg·kg -1 caffeic acid was administered alone via an intramuscular route to six rabbits each in a crossover treatment protocol. (tmu.edu.tw)
  • We observed an increased dose dependent inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL)-induced multinuclear tartarate resistant acid phosphatase (TRAP) positive osteoclast formation by F-CAPE compared to the parental compound. (pcom.edu)
  • In this study, a 3D printing scaffold based on carbon dots- curcumin nano- drug release (CCNPs) was developed as a local drug delivery platform (named CCNACA using CCNPs, Sodium alginate , Nanoclay and Caffeic Acid grafted Chitosan as raw materials), which has the ability to visualize drug release . (bvsalud.org)
  • His areas of research include adaptogens, probiotics, and essential fatty acids. (florahealth.com)
  • Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo . (inabj.org)
  • Caffeic acid induced apoptosis in MG63 osteosarcoma cells through activation of caspases. (inabj.org)
  • Sandra F, Rizal MI, Wahid AHA, Andajana M, Celinna M. Caffeic acid induces intrinsic apoptotic pathway in mg-63 osteosarcoma cells through bid truncation and cytochrome c release. (inabj.org)
  • Caffeic acid and related o-diphenols are rapidly oxidized by o-diphenol oxidases in tissue extracts. (wikipedia.org)
  • The cost of raw materials used to produce caffeic acid, such as plant extracts or synthetic precursors, can significantly impact pricing.Fluctuations in the cost of these materials can lead to price variations. (hzfoodic.com)
  • As a response, the caffeic acid content of the extracts was determined by HPLC. (biomedcentral.com)
  • In this study, the optimization of extraction process parameters of caffeic acid content from Spirulina platensis is performed by supercritical green technology. (biomedcentral.com)
  • A 2000 study looked at the effects of caffeic acid on oral cancer cells. (zhenyibio.com)
  • In 1988, researchers studied the effect of caffeic acid on tumors in mice. (zhenyibio.com)
  • Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery. (bvsalud.org)
  • It was concluded that caffeine and caffeic acid have anticancer properties and inhibit the growth of estrogen receptor cells. (zhenyibio.com)
  • Glutathione and thiol compounds (cysteine, thioglycolic acid or thiocresol) or ascorbic acid have a protective effect on browning and disappearance of caffeic acid. (wikipedia.org)
  • Quantification of glutathione, catechin and caffeic acid in grape juice and wine by a novel ultra-performance liquid chromatography method / D. Fracassetti, N. Lawrence, A.G.J. Tredoux, A. Tirelli, H.H. Nieuwoudt, W.J. Du Toit. (unimi.it)
  • abstract = "The impacts of caffeic acid (3,4-dihydroxycinnamic acid, CA) on the pharmacokinetics of levodopa (L-dopa) were studied in rabbits. (tmu.edu.tw)
  • A 2015 study using 1,090 people with breast cancer examined the effects of caffeine and caffeic acid on breast cancer growth, in relation to the disease's estrogen receptor status. (zhenyibio.com)
  • Caffeine and caffeic acid inhibit growth and modify estrogen receptor (ER) and insulin-like growth factor I receptor (IGF-IR) levels in human breast cancer. (lu.se)
  • They need to metabolize and remove wastes and other compounds in the bloodstream using a variety of enzymes supported by key nutrients like amino acids, B and C vitamins, zinc, selenium, iron, and sulfur. (florahealth.com)
  • Shifting to fatty acid metabolism for energy can be difficult. (totalhealthmagazine.com)
  • The goal is not to be ketogenic all the time, but to be able to metabolize ketones and free fatty acids routinely and easily. (totalhealthmagazine.com)
  • A nonessential amino acid but may be essential for individuals with certain diseases or nutritional concerns. (diagnose-me.com)
  • Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. (wikipedia.org)
  • We engineered tobacco plants with a fungal bioluminescence system that converts caffeic acid (present in all plants) into luciferin and report self-sustained luminescence that is visible to the naked eye. (nature.com)
  • Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid in humans. (wikipedia.org)
  • Cerebral protective and cognition-improving effects of sinapic acid in rodents. (aaem.pl)
  • Another more recent study in 2013 showed that caffeic acid strongly inhibited inflammatory enzymes. (zhenyibio.com)
  • Mid kale, daraasad dhowaan la sameeyay 2013 ayaa muujisay in caffeic acid ay si adag u xakamayso enzymes bararka. (wisepowder.com)
  • Caffeic acid waxay ku milmaysaa dareerayaasha organic sida ethanol, DMSO, iyo dimethyl formamide, kaas oo ay tahay in lagu nadiifiyo gaas aan shaqaynayn. (wisepowder.com)
  • Nardini M, Cirillo E, Natella F, Scaccini C. Absorption of phenolic acids in humans after coffee consumption. (inabj.org)
  • Caffeate 3,4-dioxygenase is an enzyme that uses caffeic acid and oxygen to produce 3-(2-carboxyethenyl)-cis,cis-muconate. (wikipedia.org)
  • The crosslinked gelatins by tannic acid significantly improved the denaturation temperature and their thermal stability was higher than that of caffeic acid. (ac.ir)
  • Chemical oxidation of caffeic acid in acidic conditions using sodium periodate leads to the formation of dimers with a furan structure (isomers of 2,5-(3′,4′-dihydroxyphenyl)tetrahydrofuran 3,4-dicarboxylic acid). (wikipedia.org)
  • MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. (inabj.org)
  • Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. (inabj.org)
  • In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. (inabj.org)
  • Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. (inabj.org)
  • In doing so, caffeic acid also prevents breast cancer from continuing to grow. (zhenyibio.com)
  • Taurine is a non-essential amino acid, synthesized in the body from methionine and cysteine. (diagnose-me.com)
  • Caffeic Acid moisturizes the skin and stimulates the synthesis of collagen and elastin fibers, rebuilding it, has a soothing and anti-imflammatory, antipigmentation effect. (biochemicals.cn)
  • Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. (inabj.org)

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