Caffeic Acids: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.Chlorogenic Acid: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).Coumaric Acids: Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.Quinic Acid: An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)CinnamatesPropolis: A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.Hydroxybenzoates: Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Lamiaceae: The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).Rutin: A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.Depsides: Phenolic benzoic acid esters.PicratesLonicera: A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.Ipomoea batatas: A plant species of the genus IPOMOEA, family CONVOLVULACEAE. Some cultivars are sweet and edible whereas bitter varieties are a source of SAPONINS. This sweet potato is sometimes referred to as a yam (DIOSCOREA).Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Polyphenols: A large class of organic compounds having more than one PHENOL group.Coffee: A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.PhenylpropionatesGlucosidesEchinacea: A genus of perennial herbs used topically and internally. It contains echinacoside, GLYCOSIDES; INULIN; isobutyl amides, resin, and SESQUITERPENES.Rhodobacter: A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Catechol Oxidase: An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.Honey: A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Eupatorium: A plant genus of the family ASTERACEAE. Ingestion has been associated with MILK SICKNESS. The common name of thoroughwort is also used for other plants including CHROMOLAENA; Hebeclinium, and Koanophyllon.Salvia officinalis: A plant species of the Salvia genus known as a spice and medicinal plant.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Siloxanes: Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.United States Government Agencies: Agencies of the FEDERAL GOVERNMENT of the United States.Nisin: A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.Judgment: The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Lipoxygenases: Dioxygenases that catalyze the peroxidation of methylene-interrupted UNSATURATED FATTY ACIDS.Cytotoxins: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Trace Elements: A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Isotopes: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.EstersCell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)

Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (1/401)

The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. Substrates containing a -COOH group are inhibitors for catechol oxidase. The products of enzymic oxidation of caffeic acid were analyzed and isolated by HPLC with diode array detection. The neolignans of the 2,3-dihydro-1,4-benzodioxin type (3, 6-8), 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-2,3-dicarboxy-1,2-dihydro naphthaline (1) 6,7-dihydroxy-1-(3,4-dihydroxyphenyl)-3-carboxynaphthaline (5) and 2,6-bis-(3',4'-dihydroxyphenyl)-1-carboxy-3-oxacyclo-(3,0)-pent an-2-on-1-ene (4) were formed. A reaction mechanism for the formation of (1, 4 and 5) is discussed.  (+info)

Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase. (2/401)

In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and dopa decarboxylase and showed hypotensive activity in the SH rat.  (+info)

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. (3/401)

We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 microg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediated induction of PGE2 synthesis. This relatively low concentration of CAPE did not affect amounts of cyclooxygenase (COX) enzymes. CAPE nonselectively inhibited the activities of baculovirus-expressed hCOX-1 and hCOX-2 enzymes. TPA- and A23187-stimulated release of arachidonic acid from membrane phospholipids was also suppressed by CAPE (4-8 microg/ml). Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA. Transient transfections using human COX-2 promoter deletion constructs were performed; the effects of TPA and CAPE were localized to a 124-bp region of the COX-2 promoter. In the rat carrageenan air pouch model of inflammation, CAPE (10-100 mg/kg) caused dose-dependent suppression of PG synthesis. Amounts of COX-2 in the pouch were markedly suppressed by 100 mg/kg CAPE but were unaffected by indomethacin. These data are important for understanding the anticancer and anti-inflammatory properties of CAPE.  (+info)

Genetic analysis of a chromosomal region containing vanA and vanB, genes required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter. (4/401)

VanA and VanB form an oxygenative demethylase that converts vanillate to protocatechuate in microorganisms. Ferulate, an abundant phytochemical, had been shown to be metabolized through a vanillate intermediate in several Pseudomonas isolates, and biochemical evidence had indicated that vanillate also is an intermediate in ferulate catabolism by Acinetobacter. Genetic evidence supporting this conclusion was obtained by characterization of mutant Acinetobacter strains blocked in catabolism of both ferulate and vanillate. Cloned Acinetobacter vanA and vanB were shown to be members of a chromosomal segment remote from a supraoperonic cluster containing other genes required for completion of the catabolism of ferulate and its structural analogs, caffeate and coumarate, through protocatechuate. The nucleotide sequence of DNA containing vanA and vanB demonstrated the presence of genes that, on the basis of nucleotide sequence similarity, appeared to be associated with transport of aromatic compounds, metabolism of such compounds, or iron scavenging. Spontaneous deletion of 100 kb of DNA containing this segment does not impede the growth of cells with simple carbon sources other than vanillate or ferulate. Additional spontaneous mutations blocking vanA and vanB expression were shown to be mediated by IS1236, including insertion of the newly discovered composite transposon Tn5613. On the whole, vanA and vanB appear to be located within a nonessential genetic region that exhibits considerable genetic malleability in Acinetobacter. The overall organization of genes neighboring Acinetobacter vanA and vanB, including a putative transcriptional regulatory gene that is convergently transcribed and overlaps vanB, is conserved in Pseudomonas aeruginosa but has undergone radical rearrangement in other Pseudomonas species.  (+info)

The rabbit lens epithelial cell line N/N1003A requires 12-lipoxygenase activity for DNA synthesis in response to EGF. (5/401)

PURPOSE: Cultured rat lenses and primary human lens epithelial cells (HLECs) express12-lipoxygenase (12-LOX) and require a 12-LOX metabolite of arachidonic acid for growth in response to EGF and insulin. This study seeks to identify an established cell line with these characteristics. METHODS: Immunoblotting was used to screen eight lens epithelial cell lines for 12-LOX expression: the human line, HLE-B3; mouse lines alphaTN4, 17EM15, 21EM15, and MLE6, and rabbit lines N/N1003A, LEP2 and B3. DNA synthesis was measured as incorporation of 3H-thymidine into DNA. Expression of c-fos mRNA was detected by RT-PCR. The involvement of 12-lipoxygenase metabolites was determined using the lipoxygenase inhibitors baicalein, cinnamyl 3,4-dihydroxy-alpha-cyanocinnamate (CDC), or nordihydroguiairetic acid (NDGA). RESULTS: 12-LOX was detected only in the rabbit lines N/N1003A, LEP2 and B3. N/N1003A cells were chosen for further study. 12-LOX inhibitors blocked DNA synthesis in response to EGF with or without insulin. Inhibition of EGF-stimulated DNA synthesis was reversed by 0.3 microM to 3 microM 12(S)hydroxyeicosatetraenoic acid (HETE), but not by equivalent concentrations of 5(S)HETE, 8(S)HETE, 15(S)HETE, or 12(R)HETE. Baicalein prevented EGF induction of c-fos mRNA. The transformed HLEC line, HLE-B3, showed little stimulation of DNA synthesis in response to EGF and was unaffected by the presence of 12-LOX inhibitors. CONCLUSIONS: N/N1003A cells, like primary cultured human lens epithelial cells or neonatal rat lenses, require 12-LOX activity for EGF dependent growth. This line will be useful for studies of the mechanism of action of 12(S)HETE.  (+info)

An early salicylic acid-, pathogen- and elicitor-inducible tobacco glucosyltransferase: role in compartmentalization of phenolics and H2O2 metabolism. (6/401)

Treatment of tobacco cell suspension cultures with a fungal elicitor of defense responses resulted in an early accumulation of the phenylpropanoid glucosyltransferase TOGT, along with the rapid synthesis and secretion of scopolin, the glucoside of scopoletin. Elicitor-triggered extracellular accumulation of the aglycone scopoletin and of free caffeic and ferulic acids could only be revealed in the presence of diphenylene iodonium, an inhibitor of extracellular H2O2 production. Our results strongly support a role for TOGT in the elicitor-stimulated production of transportable phenylpropanoid glucosides, followed by the release of free antioxidant phenolics into the extracellular medium and subsequent H2O2 scavenging.  (+info)

The small intestine can both absorb and glucuronidate luminal flavonoids. (7/401)

We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.  (+info)

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. (8/401)

The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents. Arachidonic acid (AA), a biologically active fatty acid, plays a crucial role as a mediator of signaling pathways involved in cell proliferation and survival. In this study, we investigated the potential role of AA as a proapoptotic agent in CML. Pretreatment of human CML isolated progenitor cells with AA (100 microM for 18 h) induced 71-75% inhibition of in vitro colony formation of granulocyte-macrophage colony-forming units, multilineage colony-forming units, and erythroid burst-forming units. This inhibition was significantly greater than the effect on normal progenitor cells (19-39% growth inhibition of erythroid burst-forming units, multilineage colony-forming units, and granulocyte-macrophage colony-forming units). AA also inhibited growth of the bcr-abl-transformed cell line H7.bcr-abl A54. In contrast, a minimal effect of AA on inhibition of cell growth was observed in the parental nontransformed NSF/N1.H7 cell line. The antiproliferative effect of AA was associated with apoptosis. Gamma-linolenic acid, a precursor of AA, also inhibited cell growth, whereas other unsaturated and saturated fatty acids had no effect. Pharmacological inhibition of cyclooxygenase, lipooxygenase, and cytochrome P450 monooxygenase enzymes prior to exposure to AA did not rescue cells from the inhibitory effect of AA. Moreover, 5,8,11,14-eicosatetraynoic acid, a nonmetabolizable arachidonate analogue, also inhibited cell growth, suggesting that the effect of AA did not require further metabolism. Treatment with antioxidants prior to stimulation with AA was also ineffective in preventing its antiproliferative effect. Thus, AA inhibited proliferation of CML cells by inducing apoptotic cell death. The signaling mechanisms of AA-induced inhibition of cell growth appeared to be independent of its conversion into eicosanoids or free radical generation.  (+info)

*Naturally occurring phenols

Homogentisic acid 9 C6-C3 1 Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones Caffeic, ferulic acids, ... Phenolic acids, Phenolic aldehydes Gallic, salicylic acids 8 C6-C2 1 Acetophenones, Tyrosine derivatives, Phenylacetic acids 3- ... Hypogallic acid, caffeic acid, paeoniflorin and pikuroside can be isolated from the freshwater fern Salvinia molesta.[58] ... caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p-hydroxybenzaldehyde, 3,4- ...

*Tricetin 3',4',5'-O-trimethyltransferase

Zhou, J.M.; Seo, Y.W.; Ibrahim, R.K. (2009). "Biochemical characterization of a putative wheat caffeic acid O-methyltransferase ...

*Echinacoside

It is a caffeic acid glycoside from the phenylpropanoid class. It is constituted from a trisaccharide consisting of two glucose ... and one rhamnose moieties glycosidically linked to one caffeic acid and one dihydroxyphenylethanol (hydroxytyrosol) residue at ...

*Chelidonium

Caffeic acid derivatives, such as caffeoylmalic acid, are also present. The effect of the fresh herb is of a mild analgesic, ... Hydroxycinnamic Acid Derivatives, Caffeoylmalic and New Caffeoylaldonic Acid Esters, from Chelidonium majus. Hahn R and ...

*Arachidonate 5-lipoxygenase inhibitor

... caffeic acid, curcumin, hyperforin and St John's wort. Antileukotriene agents David L. Nelson, Michael M. Cox. Lehninger's ...

*Phenols

Hypogallic acid, caffeic acid, paeoniflorin and pikuroside can be isolated from the freshwater fern Salvinia molesta. In ... caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p-hydroxybenzaldehyde, 3,4- ... "Nonenzymic Autoxidative Reactions of Caffeic Acid in Wine". Johannes J. L. Cilliers and Vernon L. Singleton, Am. J. Enol. Vitic ... For example, ellagic acid is a dimer of gallic acid and forms the class of ellagitannins, or a catechin and a gallocatechin can ...

*Kyselina kávová - Wikipédia

Chemical Land [online]. Caffeic Acid as Carbocyclic Carboxylic Acid. Dostupné online.. Zdroj[upraviť , upraviť zdroj]. Tento ... článok je čiastočný alebo úplný preklad článku Caffeic acid na anglickej Wikipédii. ...

*Hypericum perforatum

Phenolic acids (e.g. chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, p-hydroxybenzoic acid, vanillic acid) ... Saturated fatty acids (e.g. isovaleric acid (3-methylbutanoic acid), myristic acid, palmitic acid, stearic acid) Alkanols (e.g ... Chlorogenic acid Caffeic acid Kielcorin Norathyriol St John's wort is being studied for effectiveness in the treatment of ... Jaikang, C; Niwatananun, K; Narongchai, P; Narongchai, S; Chaiyasut, C (August 2011). "Inhibitory effect of caffeic acid and ...

*Fenetil estar kofeinske kiseline - Википедија, слободна енциклопедија

Caffeic acid phenethyl ester. Преузето из „https://sr.wikipedia.org/w/index.php?title=Fenetil_estar_kofeinske_kiseline&oldid= ...

*Phenolic content in wine

... fertaric acids. In wine they are present also in the free form (trans-caffeic, trans-p-coumaric, and trans-ferulic acids).[27] ... The non-flavonoids include the stilbenoids such as resveratrol and phenolic acids such as benzoic, caffeic and cinnamic acids. ... Hydroxycinnammic acids[edit]. Hydroxycinnamic acids are the most important group of nonflavonoid phenols in wine. The four most ... As the wine ages, anthocyanins will react with other acids and compounds in wines such as tannins, pyruvic acid and ...

*Verbascoside

Andary, C; Wylde, R; Laffite, C; Privat, G; Winternitz, F (1982). "Structures of verbascoside and orobanchoside, caffeic acid ... Verbascoside is a caffeoyl phenylethanoid glycoside in which the phenylpropanoid caffeic acid and the phenylethanoid ... caffeic acid, decreases the spontaneous mutation rate in the ST cross". Food and Chemical Toxicology. 50 (3-4): 1082-90. doi: ... "Phenylethanoids in the Herb of Plantago lanceolataand Inhibitory Effect on Arachidonic Acid-Induced Mouse Ear Edema1". Planta ...

*Phyllanthus acidus

P. acidus contains 4-hydroxybenzoic acid, caffeic acid, adenosine, kaempferol and hypogallic acid. While the wood is strong and ...

*Helicteres isora

Well identified active phytoconstituents includes Gallic acid, Caffeic acid, vanillin, p-Coumaric acid. From Bean and cowrkers ... 1999) isolated rosmarinic acid and their derivatives; isoscutellarein and their derivatives; D-glucopyranosyl isorinic acid ... with rosmarinic acid; Helisterculins A and B; Helisorin. It is a good source of carbohydrates, proteins, fiber, calcium, ...

*Sutorius eximius

Other compounds reported to occur in the fruit bodies include gyroporin and caffeic acid. Halling RE, Nuhn M, Fechner NA, ...

*Orthosiphon stamineus

Phytochemicals isolated from the herb include terpenes, flavonoids, caffeic acid derivatives and essential oils. Sinensetin is ...

*Scopolin

Steck, Warren (1967). "The Biosynthetic Pathway from Caffeic Acid to Scopolin in Tobacco Leaves". Canadian Journal of ... Hino F, Okazaki M and Miura Y (1982). "Effect of 2,4-dichlorophenoxyacetic acid on glucosylation of scopoletin to scopolin in ...

*Cynarine

... it is an ester formed from quinic acid and two units of caffeic acid. It inhibits taste receptors, making water (and other ... List of drugs: Cp-Cz Chlorogenic acid Panizzi, Luigi; Scarpati, Maria Luisa (1954). "Constitution of Cynarine, the Active ... Cynarine is a hydroxycinnamic acid and a biologically active chemical constituent of artichoke (Cynara cardunculus). Chemically ...

*Clerodendrum infortunatum

Fumaric acid, caffeic acid esters, β-sitosterol and β-sitosterol glucoside were isolated from the flowers. Apigenin, acacetin ...

*Taraxacum officinale

... caffeic acid, and chlorogenic acid. Dandelion also contains terpenoids, triterpenes, and sesquiterpenes. Dandelion has been ...

*Thiamine

Some examples of these antagonists are caffeic acid, chlorogenic acid, and tannic acid. These compounds interact with the ... Thiamine and its acid metabolites (2-methyl-4-amino-5-pyrimidine carboxylic acid, 4-methyl-thiazole-5-acetic acid, and thiamine ... PDH links glycolysis to the citric acid cycle, while the reaction catalyzed by OGDH is a rate-limiting step in the citric acid ... In particular in E. coli, it seems to play a role in response to amino acid starvation. Adenosine thiamine triphosphate (AThTP ...

*Aronia

... caffeic acid, delphinidin, petunidin, pelargonidin, peonidin, and malvidin. All these except caffeic acid are members of the ... whereas red and purple aronia are richer in phenolic acid and proanthocyanins. The plant produces these pigments mainly in the ... hydroxycinnamic acids, and proanthocyanidins". Journal of Agricultural and Food Chemistry. 61 (36): 8581-8. doi:10.1021/ ...

*Echinacea purpurea

... contains multiple substances, such as polysaccharides, caffeic acid derivatives (including cichoric acid), ... Eastern Purple Coneflower (Echinacea purpurea) Manček, Kreft S (2005). "Determination of cichoric acid content in dried press ...

*Ilex aquifolium

... also contains saponins, theobromine (a xanthine), ilicin, caffeine, caffeic acid, and a yellow pigment, ...

*Lonicera japonica

Other phenolic compounds present in the plant are hyperoside, chlorogenic acid and caffeic acid. The two secoiridoid glycosides ... 4-di-O-caffeoylquinic acid, methyl 3,4-di-O-caffeoylquinate, protocatechuic acid, methyl chlorogenic acid and luteolin. The two ... Peng, Youyuan; Liu, Fanghua; Ye, Jiannong (2005). "Determination of Phenolic Acids and Flavones in Lonicera japonica Thumb. By ...

*Phenols

Hydroxycinnamic acids, Phenylpropenes, Coumarins, Isocoumarins, Chromones. Caffeic, ferulic acids, Myristicin, Eugenol, ... Hypogallic acid, caffeic acid, paeoniflorin and pikuroside can be isolated from the freshwater fern Salvinia molesta.[71] ... caffeic, p-coumaric and salicylic acid, cinnamic acid and hydroxybenzaldehydes such as p-hydroxybenzaldehyde, 3,4- ... Gallic, salicylic acids. 8. C6-C2. 1. Acetophenones, Tyrosine derivatives, Phenylacetic acids. 3-Acetyl-6-methoxybenzaldehyde, ...

*Coomassie Brilliant Blue

A protein sample is added to a solution of the dye in phosphoric acid and ethanol. Under the acid conditions the dye is ... The two sulfonic acid groups have extremely low pKa and will normally be negatively charged, thus at a pH of around zero the ... The sheet was then soaked in sulfosalicylic acid to fix the protein bands and then transferred to a solution of the dye.[10] ... Through a study done at the University of Albany, it was shown that the ability of the Coomassie dye to target amino acids with ...
Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol ring of caffeic acid esters in the presence of sodium benenesulfinate and sodium toluensulfinate as nucleophiles. Both heterocycle esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against HeLa, SK-OV-3, and HT-29 cancer cell lines. HeLa cells showed the highest sensitivity to the compounds and heterocyclic esters with no substituent on catechol ring showed better activity compared to their substituted counterparts. QSAR studies reemphasized the importance of molecular shape of the compounds for their cytotoxic activity.
AIM: Caffeic acid has been described as active against bacteria commonly isolated from wound infections. However, its low stability and poor solubility reduce caffeic acid applicability as a pharmaceutical product. These parameters can be enhanced by complexation with cyclodextrin. The main goal of the present work was to incorporate caffeic acid on cyclodextrin-based hydrogels capable of controlled delivery, in order to be used as antibacterial wound dressing. MATERIALS & METHODS: Cyclodextrin-based hydrogels were prepared by direct crosslinking of -cyclodextrin or hydroxypropyl--cyclodextrin with 1,4-butanediol diglycidyl ether in the presence of hydroxypropyl methylcellulose. RESULTS: The hydrogels obtained combine good physicochemical properties (viscoelasticity, superabsorbency and high ability to retain and deliver caffeic acid) with the preservation of caffeic acid antibacterial activity and effect on fibroblasts, with gel--cyclodextrin the most suited. CONCLUSION: The hydrogels obtained ...
Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke results from a temporary or permanent reduction of cerebral blood flow that leads to functional and structural damage in different brain regions. Despite decades of intense research, the beneficial treatment of stroke remains limited. In light of this, the search for effective means ameliorating cerebral ischemia-reperfusion injury (CIRI) is one of the major problems of experimental medicine and biology. Recently, the 5-Lipoxygenase (5-LO, a key enzyme metabolizing arachidonic acid to produce leukotrienes) inhibitors have been showed to protect brain against ischemic damage in animal model of cerebral ischemia. Caffeic acid, an inhibitor of 5-LO, is a phenolic compound widely distributed in medicinal plants. The aim of this study was to investigate the effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. The study was carried out on 45 rats that were randomly divided into five groups:
TY - JOUR. T1 - Letter to the Editor regarding "Effects of caffeic acid on cisplatin-induced hair cell damage in HEI-OC1 auditory cells". AU - Kim, Shin Hye. AU - Choi, June. AU - Park, Moo Kyun. PY - 2016/2/1. Y1 - 2016/2/1. UR - http://www.scopus.com/inward/record.url?scp=84969724108&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84969724108&partnerID=8YFLogxK. U2 - 10.1016/j.ijporl.2015.12.010. DO - 10.1016/j.ijporl.2015.12.010. M3 - Letter. C2 - 26786961. AN - SCOPUS:84969724108. VL - 81. JO - International Journal of Pediatric Otorhinolaryngology. JF - International Journal of Pediatric Otorhinolaryngology. SN - 0165-5876. ER - ...
In tissue cultures, caffeic acid inhibits the development of human breast cancer cells, and of melanoma skin cancer cells. Many different studies have confirmed this response to caffeic acid. The medical journal, Cancer Research, has proposed that the caffeic acids in propolis could even help to prevent colon cancer, because in experiments, propolis stopped the formation of cancerous growths in rats which had been exposed to carcinogens. Much study continues to be done with caffeic acid and propolis ...
The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenicacid increase vitamin e and cholesterol concentrations in Sprague-Dawleyrats. ...
Rapamycin (Sirolimus?) is used to avoid rejection of transplanted organs and coronary restenosis. had been treated with rapamycin (0.25 mg/kg i.p.) or automobile (DMSO) with/without inhibitor of JAK2 (AG-490) or STAT3 (stattic). 1 hour later on the hearts were put through I/R either in Langendorf ligation or mode oleft coronary artery. Caffeic acid Additionally major murine cardiomyocytes had been put through simulated ischemia/reoxygenation (SI-RO) damage targeted knockdown of STAT3 lentiviral vector formulated with brief hairpin RNA was injected into still left ventricle 3 weeks ahead of initiating I/R damage. Infarct size cardiac function cardiomyocyte apoptosis Caffeic acid and necrosis were assessed. Rapamycin decreased infarct size improved cardiac function pursuing I/R limited cardiomyocytes necrosis aswell as apoptosis Caffeic acid pursuing SI-RO that have been obstructed by AG-490 and stattic. In situ knock-down of STAT3 attenuated rapamycin-induced security against I/R damage. ...
The amount of dietary trace elements absorbed from a meal depends, among other factors, on the quantities of certain minor plant constituents present in the meal. These substances can act as ligands and bind trace elements in the digestive tract in a
ABSTRACTPhenolic acids have been associated to a wide range of important health benefits underlain by a common molecular mechanism of action. Considering that significant membrane permeation is prevented by their hydrophilic character, we hypothesize that their main effects result from the interplay
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The protective effect of caffeic acid on ferric-induced pancreatic injury was investigated using ex vivo and in silico models. Incubation of pancreatic tissues with Fe2+led to significant depleted...
Flavonoid glycosides and caffeic acid derivatives are widely distributed in the plant kingdom. Many crops owe their red or blue color to the presence of anthocyanins. Their hue depends on their structure, pH and presence of chelating metal ions. Obviously, they are important for visual plant quality. Furthermore, polyphenolic compounds like flavonoids and phenolic acids are reported to have beneficial effects on our health by providing high antioxidant and radical scavenging activity. Yet, studies on health promoting effects are discussed controversially. Results differ between in vitro and in vivo experiments which were conducted with single or several substances or plant extracts. Some of these differences are probably due to varying bioavailability, synergisms between substances and matrix effects. In plants, foliar flavonoids can serve as photoprotectants and shield the photosystem from excess energy and UV radiation. Additionally, they play important roles in the plants interaction with ...
Kudugunti, S. K., Vad, N. M., Whiteside, A. J., Naik, B. U., Yusuf, M. A., Srivenugopal, K. S., & Moridani, M. Y. (2010). Biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) selective toxicity towards melanoma cell lines. Chemico-Biological Int ...
Our present results establish for the first time that MTI-induced apoptosis and 15-LOX-1 expression are linked mechanistically in colorectal cancer cells. The demethylating agents 5-Azadc, 5-azacytidine, and zebularine can induce 15-LOX-1 expression, indicating that methylation may play a role in 15-LOX-1 regulation. 5-Azadc induced 15-LOX-1 expression in a dose- and time-dependent manner and induced growth arrest and apoptosis in Caco-2 colon cancer cells. Inhibiting 15-LOX-1 with caffeic acid (at the 2.2 μmol/L concentration shown to be specific for 15-LOX-1 inhibition) or siRNA attenuated 5-Azadc-induced growth inhibition and apoptosis, indicating a direct relationship between 15-LOX-1 and these biological effects. These findings identify a molecular mechanism by which MTIs induce apoptosis and other cellular effects and further elucidate the role of 15-LOX-1 in human colorectal carcinogenesis. Our findings are consistent with results of other studies, which showed a 15-LOX-1-apoptosis link ...
Moleculin Biotech (previously Moleculin), a spin-off company of the University of Texas M.D. Anderson Cancer Center, is developing caffeic acid analogues as
Fig. S1. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the indicated concentrations of CAPE (0-100 μM). The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells were measured by flow cytometry.. Fig. S2. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and anti-CD28 monoclonal antibodies (2 μg/ml) stimulation. The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells from four asthmatic patients were measured by flow cytometry.. Fig. S3. Caffeic acid phenethyl ester (CAPE) inhibits interferon (IFN)-γ and interleukin (IL)-5 production by polarized T helper type 1 (Th1) and Th2 cells. Polarized helper T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and ...
TY - JOUR. T1 - Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. AU - Lin, Hui Ping. AU - Lin, Ching Yu. AU - Huo, Chieh. AU - Hsiao, Ping Hsuan. AU - Su, Liang Cheng. AU - Jiang, Shih Sheng. AU - Chan, Tzu Min. AU - Chang, Chung Ho. AU - Chen, Li Tzong. AU - Kung, Hsing Jien. AU - Wang, Horng Dar. AU - Chuu, Chih Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells. We identified that CAPE treatment significantly reduced ...
We found that micromolar concentrations of caffeic acid phenethyl ester blocked voltage-gated sodium channel activity in several invasive cell lines from different cancers, including breast (MDA-MB-231 and MDA-MB-468), colon (SW620) and non-small cell lung cancer (H460). In the MDA-MB-231 cell line, which was adopted as a model, long-term (48h) treatment with 18μM caffeic acid phenethyl ester reduced the peak current density by 91% and shifted steady-state inactivation to more hyperpolarized potentials and slowed recovery from inactivation. The effects of long-term treatment were also dose-dependent, 1μM caffeic acid phenethyl ester reducing current density by only 65%. The effects of caffeic acid phenethyl ester on metastatic cell behaviours were tested on the MDA-MB-231 cell line at a working concentration (1μM) that did not affect proliferative activity. Lateral motility and Matrigel invasion were reduced by up to 14% and 51%, respectively. Co-treatment of caffeic acid phenethyl ester ...
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the anti-inflammatory effects of CAPE on Helicobacter pylori-induced NF-kappaB and AP-1 in the gastric epithelial cell line AGS. Electrophoretic mobility shift assay was used to measure NF-kappaB- and AP-1-DNA binding activity. Western blotting was used to detect IkappaB-alpha and COX-2 expression in AGS cells cocultured with H. pylori. The antiproliferative effect of CAPE was measured by MTT assay. Our results showed that caffeic phenethyl ester inhibits H. pylori-induced NF-kappaB and AP-1 DNA-binding activity in a dose (0.1-25 microg ml(-1) approximately 0.35-88 microM) and time- (15-240 min) dependent manner in AGS cells. Maximum inhibition by CAPE was observed at concentrations of 25 microg ml(-1) ( approximately 88 microM) CAPE prevented H. pylori- and cytokine-induced ...
Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cells. Treatment with CAPE decreased protein abundance of Akt, Akt1, Akt2, Akt3, phospho-Akt Ser473, phospho-Akt Thr 308, GSK3β, FOXO1, FOXO3a, phospho-FOXO1 Thr24, phospho-FoxO3a Thr32, NF-κB, phospho-NF-κB Ser536, Rb, phospho-Rb Ser807/811, Skp2, and cyclin D1, but increased cell cycle inhibitor p27Kip. Overexpression of Akt1 or Akt2 in TW2.6 cells rescued growth inhibition caused by CAPE treatment. Co-treating TW2.6 cells with CAPE and 5-fluorouracil, a commonly used chemotherapeutic drug for oral cancers, exhibited additive cell proliferation inhibition. Our study suggested that administration of CAPE is a
Caffeic acid phenethyl ester is Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Cited in 17 publications
Vascular endothelial growth factor (VEGF) is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ), bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs). In an in vitro tube formation assay, HUVECs and fibroblast cells were incubated for 14 days with VEGF and various concentrations of bee products [RJ, ethanol extract of bee pollen, ethanol extract of Chinese red propolis and its constituent, caffeic acid phenethyl ester (CAPE)]. To clarify the mechanism of in vitro angiogenesis, HUVEC proliferation and migration were induced by VEGF with or without various concentrations of RJ, bee pollen, Chinese red propolis, and CAPE. RJ, bee pollen, Chinese red propolis, and CAPE significantly suppressed VEGF-induced in vitro tube
An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.. Caffeic acid phenethyl ester, or CAPE, is a compound isolated from honeybee hive propolis, the resin used by bees to patch up holes in hives. Propolis has been used for centuries as a natural remedy for conditions ranging from sore throats and allergies to burns and cancer. But the compound has not gained acceptance in the clinic due to scientific questions about its effect on cells.. In a paper published in Cancer Prevention Research, researchers combined traditional cancer research methods with cutting-edge proteomics to find that CAPE arrests early-stage prostate cancer by shutting down the tumor cells system for detecting sources of nutrition.. "If you feed CAPE to mice daily, their tumors will stop growing. After several weeks, if you stop the treatment, the tumors will begin to grow ...
Transthyretin (TTR) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic acid phenethyl ester (CAPE) and its derivatives. Thioflavin T assay showed that CAPE suppressed the amyloid fibril formation of TTR. Comparative analysis of the inhibitory potencies revealed that phenethyl ferulate was the most potent among the CAPE derivatives. The binding of phenethyl ferulate and the selected compounds to TTR were confirmed by the 8-anilino-1-naphthalenesulfonic acid displacement and X-ray crystallography. It was also demonstrated that Bio 30, which is a CAPE-rich commercially available New Zealand propolis, inhibited ...
SOURCE: Guney M, et al. (2007). Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. 24(2):86-91.. "Fluoride is a strong, hard anion and cumulative toxic agent. The effect of fluoride intoxication on lipid peroxidation in endometrial tissue and the protective effects of combinations of vitamins E and C in rats were studied. Additionally, the apoptotic changes in endometrial tissue were examined. Experimental groups were as follows: control group; a group treated with 100 mg/l fluoride (F group); and a group treated with 100 mg/l fluoride plus vitamins E and C (F+Vit group). The F and F+Vit groups were treated orally with fluoride for 30 days. Vitamins E and C were injected simultaneously at doses of 50 mg/kg day i.m. and 20 mg/kg day body weight i.p. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis, was detected with the use of the terminal deoxynucleotidyl ...
The triple-negative breast cancer (TNBC) patients have a high mortality due to paucity of effective treatments. We have utilized human MDA-MB-231 (MDA-231) BC cells, often serving as a model of TNBC, to determine whether CAPE (caffeic acid phenethyl ester), a major medicinal component of propolis, can combat TNBC as a preventive, therapeutic, and/or adjuvant to chemotherapeutic drugs. We found that CAPE inhibits MDA-231 cell growth in vitro and in vivo. In vitro: CAPE dose-dependently inhibits MDA-231 cell growth and has a strong effect on gene and protein expression without affecting non-tumorigenic cells. It inhibits cell proliferation and anti-apoptotic genes, decreases oncogenes, inflammatory cytokines, cyclins, and certain receptors and growth factors (i.e., EGFR, IGFR-like 1&2, RAR, Egr-1, and NF-\#954;B1&2 transcription factors). CAPE also increases p21 and p27. Notably, CAPE down-regulates mdr-1 gene, considered responsible for the resistance of cancer cells to chemotherapeutic agents, ...
All propolis samples had strong anti-oxidant activity, accompanied by high total phenolic content. The most abundant compounds were flavonoids. Concerning the phenolic compounds content, our results showed that the 75% of the samples analysed contained at least 80 mg/g of flavonoids, primarily pinobanksin 3-acetate, pinocembrin, chrysin, galangin and pinobanksin. Caffeic acid phenethyl ester was detected in almost all EEP samples but in smaller proportions (mean 12.9 ± 2.8 mg/g ...
Cell Culture and Chemicals. SW1116 cells, a cell line derived from human colon adenocarcinoma, were obtained from American Type Culture Collection (Manassas, VA) and cultured in Leibovitzs L-15 medium containing 10% (v/v) heat-inactivated fetal bovine serum, 100 U/ml penicillin, and 100 μg/ml streptomycin. Chemicals were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise stated. Caffeic acid phenethyl ester (CAPE) was purchased from Calbiochem (San Diego, CA), and celecoxib was a kind gift from SEARLE (Evanston, IL).. Estimation of Cell Viability. Cell viability was assayed by routine 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction method. Briefly, SW1116 cells were seeded into a 96-well plate and incubated for 24 h for attachment. They were then incubated with different drugs for different times at 37°C. At the end of incubation, the medium was aspirated. The remaining cells were further incubated with 0.25 mg/ml MTT for 3 h. MTT was extracted with isopropanol ...
The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed
A novel peroxidase that catalyses the dimerization of ferulic acid or caffeic acid via oxidative coupling and formation of beta beta′-linkage to the lignan-type compounds 8,8′-bis(caffeic acid) or 8,8′-bis(ferulic acid) respectively was purified from the leaves of Bupleurum salicifolium. The enzyme, for which the name caffeate peroxidase is proposed, was purified 2700-fold. It is a glycoprotein and has an Mr of 38,000 as determined by gel filtration and SDS/PAGE. The Km values for ferulic acid and caffeic acid were 0.24 mM and for H2O2 0.04 mM with caffeic acid and 0.48 mM with ferulic acid. The purified peroxidase does not exhibit activity on other phenylpropanoids tested and has no detectable phenol oxidase or NADPH oxidase activity. The caffeate peroxidase could be involved in the biosynthesis of lignans. ...
Cryptococcosis, specifically caused by Cryptococcus neoformans, is a subacute or chronic fungal infection with several manifestations. It is commonly observed as a disseminated disease in the immunocompromised patient with approximately two thirds of patients experiencing meningitis.(3,5) Because of the wide spectrum of Cryptococcosis and the opportunistic nature of such infection, rapid laboratory identification of Cryptococcus neoformans is necessary so that therapy can be immediately initiated. The presumptive identification of Cryptococcus neoformans is based on the presence of an encapsulated yeast (using India ink), the absence of pseudohyphae, the failure to utilize an inorganic nitrate substance, and the ability to produce urease. The final identification of C. neoformans is usually based on typical substrate utilization patterns and brown pigment production in the presence of caffeic acid.(2,3,5). The brown pigmented colonies of Cryptococcus neoformans were observed by Staib in 1962 ...
Material Safety Data Sheet of Caffeic acid contains identification of substance and details of the supplier of the safety data sheet.
Authors: A.HAKAN AKTAŞ, GÜLSÜM YAŞAR, GÜLEREN ÖZKAN ALSANCAK, ŞAHİNDE DEMİRCİ Abstract: In this study, four hydroxycinnamic acids, namely 3,4-dihydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy --3- methoxycinnamic acid and 4-hydroxy-3,5-dimethoxycinnamic acid, were titrated conductimetrically and potentiometrically using triethylamine and tetrabutylammonium hydroxide in acetonitrile, 2-propanol, and pyridine solvents under a nitrogen atmosphere at 25 ^oC. In conductimetric titration with tetrabutylammonium hydroxide all of the compounds exhibited conventional stoichiometric titration curves in 2-propanol . As is evident from the titration curves, all these compounds gave two well-defined end points. The first end point corresponds to exactly one equivalent and the second one to the two equivalents of the base. In conductimetric titration with tetrabutylammonium hydroxide, all of the acids (except caffeic acid) show two end points in pyridine solvent. These compounds were ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
In this work, the near-neutral photo-Fenton process, as a means of wastewater disinfection, was enhanced by the addition of Organic Acids (OAs), namely citric, ascorbic, tartaric and caffeic acid. The addition of OAs exhibited significant bacterial inactivation enhancement, compared to the classic photo-Fenton systems (Fe2+/H2O2/solar and Fe3+/H2O2/solar). The improved disinfection performance was not attributed to pH variations by the addition of OAs, but to the increase of the initial dissolved iron in the system, facilitating the Fe3+/Fe2+ turnover in the catalytic photo-Fenton reaction and consequently, the hydroxyl radicals production. For citric and tartaric acid, increased photo-activity of the complexes was associated with their high capability to complex Fe3+ and to promote ligand-to-metal charge transfer (LMCT), which is of key importance to feed Fe2+ to the Fenton process. On the other hand, for ascorbic and caffeic acid, the acceleration of the homogeneous Fenton reaction was ...
아시안뷰티화장품학술지, Asian Journal of Beauty and Cosmetology, AJBC, 대학원, 화장품, 미용, 피부과학, 뷰티, 진학, 이미지
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One of the best fragments identified in the previous work was L-tryptophan methyl ester (compound 1), so the researchers naturally tried substituting the methyl group. A phenethyl ester (compound 5c) gave a satisfying 10-fold boost in potency, but this turned out to be the best they could get: shorter or longer linkers were both less active, and modifications around the phenyl ring gave marginal improvements at best. Also, changing the ester to an amide decreased affinity. They were, however, able to improve potency another order of magnitude by acylating the nitrogen (compound 6a ...
Each of the following at 6X, 12X, 30X, 200X, 12CH, 30CH, 60CH, 200CH.. Acetalcholine chloride Combo, Acetaldehyde Combo, Apiolum Combo, Ascorbic Aid Combo, Apiolum Combo, Ascorbic Acid Combo, BHT Combo, Caffeic acid Combo, Candida albicans Combo, Chloragenic acid Combo, Cinnamic acid Combo, Coniferyl alcohol Combo, Coumarin Combo, Dopamin Combo, Estrogen Combo, GABA Combo, Gallic acid Combo, Histamine Combo, Indole Combo, L-Dopa Combo, Malvin Combo, Mannan Combo, Melatonin Combo, Menadione Combo, Noepinephrine Combo, Octopamine Combo, Phenylalanine Combo, Phenylisothiocyanate Combo, Phloridzin Combo, Piperin Combo, Progesterone Combo, Pyrole Combo, Quercetin Combo, Rutin Combo, Salsolinol Combo, Serotonin Combo, Taurine Combo, Testosterone Combo, Tryptophan Combo, ATP 5X, Mesenchyme 6X, 9X, 6C.. ...
Hawthorns active components are mostly flavonoids (luteolin, apigenin, vitexin, rutin, and quercetin as glycosides) and procyanidins. Hawthorn is also a source of tannins or polyphenols (oligomeric cathechins and epicathechins), carboxylic acids (caffeic acid), triterpenes and simple amines (choline, acetylcholine and tyramine). Researchers were unable to find one major active ingredient. It would seem that the therapeutic effect of Hawthorn, like that of many other herbs, rests on the synergy of all of its components.(1). The various in vivo and in vitro studies have identified many of Hawthorns therapeutic effects:. Increase of cardiac contractility (positive inotropic effect). As a result, heart efficiency and ejection fraction are increased.(2). Peripheral resistance reduction (post-charge reduction). The lesser the resistance, the lesser the effort needed by the heart. The final effect is a reduction in oxygen consumption. (2). Coronary vasodilator (improves heart irrigation and oxygen ...
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trans-3-coumaric acid 14755-02-3 NMR spectrum, trans-3-coumaric acid H-NMR spectral analysis, trans-3-coumaric acid C-NMR spectral analysis ect.
Chlorogenic acid is an ester of caffeic acid and quinic acid. Chlorogenic acid is the major polyphenolic compound in coffee, isolated from the leaves and fruits of dicotyledonous plants. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal. Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid. The chlorogenic acid content of a 200 ml (7-oz) cup of coffee has been reported to range from 70-350 mg, which would provide about 35-175 mg of caffeic acid. The results of epidemiological research suggest that coffee consumption may help prevent several chronic diseases, including type 2 diabetes mellitus, Parkinsons disease and liver disease (cirrhosis and hepatocellular carcinoma). Most prospective cohort studies have not found coffee consumption to be associated with significantly increased cardiovascular disease risk. However, coffee consumption is associated with increases in several cardiovascular ...
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Umbellic acid (2,4-dihydroxycinnamic acid) is a hydroxycinnamic acid. It is an isomer of caffeic acid. It is a precursor in the umbelliferone biosynthesis pathway. Umbelliferone is a phenylpropanoid and as such is synthesized from L-phenylalanine, which in turn is produced via the shikimate pathway. Phenylalanine is lysated into cinnamic acid, followed by hydroxylation by cinnamate 4-hydroxylase to yield 4-coumaric acid. The 4-coumaric acid is again hydroxylated by cinnamate/coumarate 2-hydroxylase to yield 2,4-dihydroxy-cinnamic acid followed by a bond rotation of the unsaturated bond adjacent to the carboxylic acid group. Finally an intramolecular attack from the hydroxyl group of C2 to the carboxylic acid group closes the ring and forms the lactone umbelliferone. → P A L {\displaystyle {\xrightarrow {PAL}}} → C 4 H {\displaystyle {\xrightarrow {C4H}}} → C 2 H {\displaystyle {\xrightarrow {C2H}}} ⟶ {\displaystyle \longrightarrow } The enzyme 4-hydroxycinnamate decarboxylase, induced ...
To read the authors abstract of the article, click on the title of the article. Then, to read the full article, click on the full text icon. NOTE: Chlorogenic acid and caffeic acid are inhibitors of DNA methylation. Argan oil is a source of chlorogenic acid and caffeic acid. Green coffee bean extract contains chlorogenic […]. View Post ...
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While Jatropha aethiopica, popularly known in Cuba as "mata diabetes", is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica, leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (4), a new kaempferol 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2[α-L-rhamnopyranolsyl-(1→6)]-β-D-glucopyranoside (6), rutin (7), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (8) and quercetin (9 ...
A beloved beverage throughout the USA and the world at large, coffee is often blamed for various health woes. While coffee is not appropriate for everyone, and there is such a thing as "too much" for even the most tolerant of sippers, research has shown a vast array of health benefits.. The abundant phytochemicals found in coffee beans are responsible for the various benefits, including potential prevention of diseases such as Diabetes mellitus type II, Alzheimers disease and even cancer. Of course, we cannot overlook the well-loved stimulant effect of coffee that reliably provides us with increased stamina during exercise, and temporarily improves our cognitive function. Moreover, coffee simply makes mornings tastier.. Following is a brief overview discussing a few of the benefits to coffee consumption. These are presented in defense of coffee and as a thank you to its many active phytochemicals, including caffeine, caffeic acid, hydroxyhydroquine, chlorogenic acid, cafestol and ...
Results: DMEP-A exhibited cytotoxic activity on HN30 cells with significantly decreased viability at 200 μg/ml compared with the control (p , 0.05). However, no significant cytotoxic effect was evident in HN31 cells. DMEP-B and DMEP-C significantly decreased the viability of both cell lines from 100-200 μg/ml and 50-200 μg/ml, respectively (p , 0.05). Interestingly, HN31 cells were more toxically sensitive compared with the HN30 cells when treated with DMEP-B and DMEP-C. IC50 values for DMEP-B with HN30 and HN31 cells were more than 200 μg/ml and 199.8±1.05 μg/ml, respectively. The IC50 of DMEP-C to HN30 and HN31 cells was found to be 114.3±1.29 and 76.33±1.24 μg/ml, respectively. Notably, apigenin, pinocembrin, p-coumaric acid, and caffeic acid were not detected in our propolis extracts ...
Guo, D.J., Chen, F., Inoue, K., Blount, J.W., and Dixon, R.A., 2001, Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa: Impacts on lignin structure and implications for the biosynthesis of G and S lignin, Plant Cell 13:73-88.CrossRefPubMedGoogle Scholar ...
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Hitching Post (Bourbon Stout) is a American Stout style beer brewed by Cape May Brewing Company in Cape May, NJ. 3.56 average with 4 ratings, reviews and opinions.
In wrinkle formation, caffeic acid and S-allyl cysteine found in garlic significantly inhibited the degradation of type І procollagen and the expressions of MMPs in vivo and attenuated the histological collagen fiber disorder and oxidative stress in vivo, through decreased oxidative stress and inflammation by modulating the activities of NF-κB and AP-1, and exhibited an indirect anti-oxidant effect by suppressing cyclooxygenase-2 (COX-2) and induced nitric oxide synthase (iNOS) expressions levels and down-regulated transcriptional factors(1). Its garlics antioxidant properties may either prevent or delay chronic diseases associated with aging(2). According to Aarhus University, garlic not only protected skin cell from undergo aging process but also inhibited the abnormal growth of skin cells, through its on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts(3 ...
Heres-Pulido, M.E., G. Avila-Acevedo, H. Dionicio-Lopez, G.L.B. Hernandez-Portilla, L. Castaneda-Partida, A.M. Garcia-Bores, G. Martinez-Cortes, S.L. Cardenas, G. Ceron, K. Tavera-Briseno, A. Vargas-Vera, and I.E. Duenas-Garcia. Non toxicity of phenylpropanoid verbascoside from a Buddleja scordioides extract in Drosophila melanogaster flare and Oregon-flare strains and toxicity of caffeic acid in the flare strain ...
Alternative URL: http://www.nature.com/srep/2014/141124/srep07159/full/srep07159.html Abstract: In this work, synergism and antagonism among active ingredients of traditional Chinese medicine (TCM) were studied at system-level by using molecular imprinting technology. Reduning Injection (RDNI), a TCM injection, was widely used to relieve fever caused by viral infection diseases in China. Molecularly imprinted polymers (MIPs) synthesized by sol-gel method were used to separate caffeic acid (CA) and analogues from RDNI without affecting other compounds. It can realize the preparative scale separation. The inhibitory effects of separated samples of RDNI and sample combinations in prostaglandin E2 biosynthesis in lipopolysaccharide-induced RAW264.7 cells were studied. The combination index was calculated to evaluate the synergism and antagonism. We found that components which had different scaffolds can produce synergistic anti-inflammatory effect inside and outside the RDNI. Components which had ...
Horsetail, not to be confused with cat-tail, is possibly the most abundant source of silica in the plant kingdom, so much in fact that the herb can be used for polishing metal. It got the name "scouring rush" from this very application. The horsetail constitutes one of the most diuretic species in all the plants. That is to say that it possesses a great capacity to eliminate water from the body, in such a point to increase urination up to 30% more than what is habitual. This fact makes that its scientific name Equisetum arvense generally appears in the composition of most of products that habitually are sold to reduce weight. This property is due to the action of several components, among which it is necessary to highlight equisetonin and potassium, but there are another ones that also take part such as calcium, magnesium, ascorbic acid and caffeic acid. ...
Date: Mon, 15 Mar 93 12:00:25 EST From: bszymcz%ulysses at relay.nswc.navy.mil (Bill Szymczak) Subject: re: beer, root beer and cancer In HBD1095 John Sampson brought to our attention a very interesting article appearing in Science, (vol. 258 pg 261) on natural vrs. synthetic carcinogens. The fact that wine and beer were at the top of the list alerted me to read the article myself. In that article Rodent Carcinogens: Setting Priorities, the authors try to support their hypothesis that naturally occuring chemicals have not been as rigorously tested as synthetic chemicals for being potential carcinogens. This was done by using an index (HEPR) measuring the percent of the equivalent (by weight) amount of daily lifetime rat dosage required to halve cancer free rats at the end of a standard lifetime. Some of the values are: HEPR (%) HUMAN EXPOSURE (PER DAY) RAT CARCINOGEN 4.7 Wine (250ml) Ethanol (30 ml) 2.8 Beer (12 oz; 354 ml) Ethanol (18 ml) 0.3 Lettuce, 1/8 head (125 g) Caffeic acid (66.3 mg) ...
Sitting or standing for long periods of time can lead to a little more than discomfort. When youre in the same position for long periods, your blood doesnt flow as efficiently as it would with regular movement, this causes the veins to work harder to pump your blood up to your heart. The added effort can lead to the veins becoming swollen and varicose.. Whether youre currently trying to hide protruding veins or find yourself falling into a few of the risk categories above, give Dr. Jeffrey Gosin at Shore Vascular & Vein Center a call at (609) 927-VEIN (8346) for more information, get diagnosed or receive treatments. Dont let the rest of summer pass you by, get out there and show off those legs.. Serving: Cape May County: Cape May, Villas, Marmora, Avalon, Wildwood, Ocean City, West Cape May, North Cape May, Wildwood Crest, Upper Township, Middle Township, Lower Township, Woodbine, Dennis Township; Atlantic County: Somers Point, Northfield, Linwood, Egg Harbor Township, Mays Landing, ...
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Book now at The Pier House in Cape May, NJ. Explore menu, see photos and read 849 reviews: One of my favorite dining spots in Cake May - food is consistently good and service is excellent .
Book now at The Pier House in Cape May, explore menu, see photos and read 849 reviews: One of my favorite dining spots in Cake May - food is consistently good and service is excellent .
Cape May, New Jersey, boasts excellent fishing for a variety of species, including blue and white marlin, as well as one of the richest tournaments in the world.
Published in: Proceedings: 2nd Specialized Conference on Pretreatment of Industrial Wastewaters, October 16-18, 1996, Athens, Greece, p. 257-263 ...
At the Law Offices of Lawrence M. Simon, we stress personal attention and responsiveness. Our straightforward, plain-speaking approach will help you make
Hotels near Historic Cold Spring Village, Cape May on TripAdvisor: Find 24,787 traveller reviews, 3,867 candid photos, and prices for 256 hotels near Historic Cold Spring Village in Cape May, NJ.
Every year, more than half of the honeybee hives in the United States are taken to California to pollinate the state's almond crop. Biologist Laurence
Chlorogenic acids are among the most abundant phenolics found in the human diet. Of these, the mono-caffeoylquinic acids are the predominant phenolics found in fruits, such as apples and pears, and products derived from ...
I was wondering if there were any specific regulations regarding how long Maternity must keep placentas that do not meet our hospitals criteria to be sent to the lab for Pathologist evaluation. I am aware of the CLIAA -88 and CAP regulations, but they apply to specimens submitted to the lab. Thank-you for any insight, website, or information you are willing to share, Susan OBrien, Histology Supervisor Burdette Tomlin Memorial Hospital Cape May Court House, NJ _______________________________________________ Histonet mailing list [email protected] http://lists.utsouthwestern.edu/mailman/listinfo/histonet ...
Studies show that at least five compounds in coffee help reduce cancer risk:. Chlorogenic acid - This antioxidant compound is the major phenol in coffee. Its technically an ester formed between quinic acid and caffeic acid. Caffeic acid is its main component; lab studies show it increases self-destruction of cancer cells and reduces inflammation. Chlorogenic acids antioxidants may be slightly lower in decaf and in instant coffee, but theyre still abundant. Quinic acid contributes to the acidic taste of coffee and is another phytochemical with antioxidant benefits.. Cafestol and kahweol - These fat-soluble compounds are extracted from coffees oils during brewing and are most available in unfiltered coffee (as in French press or boiled coffee; to drink more of these compounds, dont use paper filters). Studies suggest kahweol and cafestol stimulate enzymes that neutralize carcinogens and block the proteins that activate carcinogens.. Caffeine - Everyone knows caffeine acts as a stimulant. Its ...
The indole alkaloid gramine occurs in leaves of certain barley (Hordeum vulgare L.) cultivars but not in others. A gene sequence in barley that earlier was characterized as a jasmonate-induced O-methyltransferase (MT) (EC 2.1.1.6, GenBank accession U54767) was here found to be absent in some barley cultivars and breeding lines that all lacked gramine. The cDNA was cloned and expressed in Escherichia coli and the recombinant protein purified. The purified recombinant protein methylated two substrates in the pathway to gramine: 3-aminomethylindole (AMI) and N-methyl-3-aminomethylindole (MAMI) at a high rate, with Km-values of 77 mu M and 184 mu M, respectively. In contrast, the protein did not exhibit any detectable methylation with the earlier suggested substrate for O-methylation, caffeic acid. A number of cultivars and breeding lines of barley were analyzed for presence of the U54767 gene sequence and NIT protein and the enzyme activity in vitro with MAMI or caffeic acid as substrates. The ...
Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit
Results. Coffee appears to induce autophagy, meaning that it upregulates the activity. This can prevent the accumulation of damaged protein and cellular components, optimizing function.. Two components of coffee, chlorogenic acid and caffeic acid appear to increase skeletal muscle glucose transport into the cell. It also increases sensitivity to insulin.. Finally, coffee intake attenuates the loss of muscle mass and strength that occurs with age. It also appears to increase the regenerative capacity of skeletal muscle in the aging adult.. Conclusions. Coffee appears to have multiple beneficial effects on skeletal muscle.. Regarding autophagy, coffee appears to help the body sweep up the damaged cellular products which can improve overall cellular activity.. It improves insulin sensitivity and glucose uptake, important not only for physical activity but for disease prevention.. Finally, it blunts the age-related skeletal muscle loss effects that occur naturally, known as sarcopenia, and may ...
The chemical interaction between plants and bacteria in the root zone can lead to soil decontamination. Bacteria which degrade PAHs have been isolated from the rhizospheres of plant species with varied biological traits, however, it is not known what phytochemicals promote contaminant degradation. One monocot and two dicotyledon plants were grown in PAH-contaminated soil from a manufactured gas plant (MGP) site. A phytotoxicity assay confirmed greater soil decontamination in rhizospheres when compared to bulk soil controls. Bacteria were isolated from plant roots (rhizobacteria) and selected for growth on anthracene and chrysene on PAH-amended plates. Rhizosphere isolates metabolized 3- and 4-ring PAHs and PAH catabolic intermediates in liquid incubations. Aromatic root exudate compounds, namely flavonoids and simple phenols, were also substrates for isolated rhizobacteria. In particular, the phenolic compounds - morin, caffeic acid, and protocatechuic acid - appear to be linked to bacterial ...
Scientific proven health benefits and uses of pineapple. • Antitumor activity: Stem bromelain, a cysteine proteinase from the pineapple stem, showed an anti-tumor effect on mice, superior to that of 5-FU with an antimetastatic action independent of the primary antitumor effect.. • Hypolipidemic: Study showed the ethanolic extract of AC inhibited HMGCoA reductase activity by 20-49% in vitro suggesting AC as a potential natural product for the treatment of hyperlipidemia. Its action differed from fibrates but was similar to statins, and as such, a possible adjuvant for fibrates.. • Phenolic Constituents: Study isolated 7 compounds from the leaves of pineapple: ananasate, 1-O-caffeoylglycerol, 1-O-coumaroylglycerol, caffeic acid, p-coumaric acid, beta-sitosterol and daucosterol.. • Anti-Diabetic / Anti-Dyslipidemic / Anti-Oxidative: Study of the ethanolic extract of Ananas comosus leaves showed anti-diabetic, anti-dyslipidemic and anti-oxidative activities - significantly decreasing blood ...
Persistent accumulation of free radicals in cells leads to oxidative stress, which plays a causative role in the induction and progression of various chronic diseases. Therapeutic focus has therefore shifted towards the use of antioxidants, with recent interest in those of plant origin. This study investigated radical scavenging and cytoprotective activities of phytochemicals (quercetin, curcumin, sulforaphane, rosmarinic acid, caffeic acid, danshensu (3,4-dihydroxyphenyllactic acid), ferulic acid and m-coumaric acid) against DPPH free radical in a non-cellular assay, and oxidative damage in hepatic (HepG2) and pancreatic (1.1B4) cells, elicited by an organic hydroperoxide (tert-butylhydroperoxide - tBHP) and a more physiologically relevant stressor (palmitate). Direct and indirect cytoprotective activities were assessed by neutral red viability assay after 5 h co-exposure and 20 h pre-exposure conditions, respectively ...
Nutritional. If you have a lack of the vitamins B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine) and B9 (folic acid), the cauliflower is the perfect vegetable for you.. Besides being rich in omega-3 fatty acids, it also contains vitamin K. Cauliflower is a very good source of proteins, phosphorus and potassium. The cauliflower is also famous for containing powerful antioxidants such as vitamin C and manganese.. Antioxidant. Even though we have mentioned some of its powerful antioxidants above, the cauliflower also contains carotenoids such as beta-carotene and phytonutrients that include kaempferol, ferulic acid, cinnamic acid and caffeic acid.. You will protect yourself from free radical damage and reduce your risk of getting a disease that is caused by oxidative stress such as cardiovascular diseases and cancer, if you include cauliflower in your everyday diet. Providing your body with these antioxidants will bring you positive results.. Detoxification. If ...
Antibodies and reagents. Phycoerythrin-labeled or FITC-labeled CD19 and TNFα antibodies and blocking Fas antibodies were purchased from PharMingen (San Francisco, CA). Lipopolysaccharide, actinomycin D, cycloheximide, and phorbol dibutyrate were from Sigma (St. Louis, MO). Stock solutions of phorbol dibutyrate (5 mg/mL) were made in DMSO. Dexamethasone (Pharmascience Inc., Montreal, Quebec), IFNα2b (Schering Canada Inc., Pointe-Claire, Quebec), Remicade (anti-TNF antibody; Schering Canada), vincristine sulfate (Faulding Canada Inc., Kirkland, Quebec), doxorubicin (Adriamycin; Pfizer, Canada Inc., Kirkland, Quebec), fludarabine phosphate (Berlex Canada Inc. Pointe-Claire, Quebec), and cyclosporin A (Novartis Canada Inc., Dorval, Quebec) were purchased from the hospital pharmacy. SP600125 (JNK inhibitor), MG-132 (proteasome inhibitor), and caffeic acid phenylester (CAPE; NF-κB inhibitor) were from Calbiochem (San Diego, CA), and stock solutions (25 mg/mL) were made in DMSO. The TLR7/8 agonist, ...
B83 The purpose of this research project was to determine the efficacy of the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors, alone or in combination, to prevent OH-BBN-induced urinary bladder cancers in female Fischer-344 rats. In this OH-BBN-induced rat model, the bladder cancers are primarily transitional cell carcinomas which are mostly papillary and slowly growing. The rats were treated for 8 weeks with OH-BBN beginning at 49 days of age, then treated with chemopreventive agents and followed for an additional 6-7 months for the appearance of urinary bladder cancers. Beginning one week following the last OH-BBN administration and continuing until the end of the study, celecoxib (a COX2 inhibitor) was administered at 500 mg/kg diet, zileuton (a LOX inhibitor) at 1200 mg/kg diet, naproxen (a nonspecific COX inhibitor) at 200 or 400 mg/kg diet, aspirin (a COX1 inhibitor) at 300 and 3000 mg/kg diet, and caffeic acid (a LOX inhibitor) at 8 and 16 grams/kg diet. At the end of the study ...
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Wilmington, Ohio (PRWEB) March 19, 2014 -- Cape May Retirement Village adds a rehab and health care center, offering guests comprehensive therapies and long
Hail to the Chiefs!"2018-02-13T09:30:00. "Hail to the Chiefs!" An exhibit that highlights more than 15 of our nations leaders, including Washington and Lincoln. On display are artifacts from the Museums collection as well as from a private collector. The exhibit featuresx original documents, books, artwork and artifacts.. Museum of Cape May County504 Route 9 NorthCape May Court HouseNJ08210 ...
Go parasailing on your vacation. Our Cape May, New Jersey parasailing rides will excite any dare devil or thrill seeker. Soar over the water on a parachute a...
Visit BedandBreakfast.com and browse 3020 guest reviews and 408 property photos for Cape May, New Jersey bed and breakfast accommodations.
This is an explanation of how I use a late winter warmup to manipulate my hives in preparation for spring nectar gathering and to minimize swarming.
Brendan was complaining about heartburn all day, and co-workers noticed he seemed lethargic and tired," said Lauren Maguire, who is Desmonds mother and an outpatient mental health counselor at Cape Counseling. "As he was bringing a trash can full of roof debris over to the edge of the roof to empty into a dumpster, his buddy suggested he just leave it and finish the next day. That is when Brendan turned to him, clutched his heart, and began to fall backward off of the roof ...
When you are visiting Cape May for the day, or if you are traveling to Cape May for a visit of several days, but cannot find a dog-friendly accommodation (more on dog friendly accommodations in a month or two!) there are several doggie day cares, pet sitters, doggie boarders, and kennels in the area; and also a great shop to purchase toys, treats, and necessities for your pets. Several of these options are listed below for your convenience.. Whether for a few hours, a day, or longer, you will want to research several choices since, just like people accommodations, each of these pet care businesses offers a variety of services in a variety of settings, and you will want to check to see which type of facility, and which specific facility best meets your, and your doggies needs. Check to see if the facility you are looking into is insured and certified. You as well as the pet care business you choose, will want to make sure that your pet is cared for happily and safely.. AND, you will want to plan ...
snapshotcapemay, Cape May, NJ. 271 likes. We travel all over Cape May County, New Jersey Taking photos, Also See http://www.snapshotcapemay.com
The phenolic compound used in this study is p-coumaric acid, which is the derivative of phenolic acid playing a role in giving color, odor and taste to the plants. The p-coumaric acid is an organic compound derived from ...
Could... could the wheres my honey cake possibly be meant to portray Winnie the Pooh clutching the remains of a burst balloon? Since in the story he tries to reach the honeybees hive by tying himself to a helium balloon (although its never specified that theres helium in the balloon, which *always* bothered me) only to require Christopher Robin to shoot the balloon with... um... a BB gun? To help him get down again, after the bees start stinging him? Okay, Im grabbing at straws here, trying desperately to come up with an explanation for the gross pink shape on that yellow creature ...
Chlorogenic acids are among the most abundant phenolics found in the human diet. Of these, the mono-caffeoylquinic acids are the predominant phenolics found in fruits, such as apples and pears, and products derived from ...
KOMENTAR PARA PAKAR TENTANG Propolis Prosmart.. Di Yunani , Propolis telah dikenal sebagai pengobatan luka-luka dan berbagai penyakit yang tidak bisa disembuhkan. Di Mesir, Propolis telah dikenal sebagai pengobatan dan simbol keagamaan. Romawi memuja lebah dan Propolis sebagai pengobatan, ahli jiwa menggunakan Propolis sebagai obat ekstrak dari sengatan dan semua jenis racun, mengurangi pembengkakan, mengendorkan…
Victoria Commons , a Genesis HealthCare facility located at North Cape May, NJ 08204, specializing in Assisted living and Driving Rehabilitation by Genesis Rehab Services.
Honeysuckle Extract is extracted from the flowers of Lonicara japonica, which contains chlorogenic acid, a phenolic natural product isolated from the le...
The influence of different brewing conditions on the concentration of the main caffeoylquinic acids (3-caffeoylquinic acid (3-CQA), 4-caffeoylquinic acid (4-CQA), and 5-caffeoylquinic acid (5-CQA)) was investigated. For this purpose, twenty-four coffee brews were extracted and analyzed using HPLC-DAD at 325 nm. Our findings demonstrate the great impact of brewing techniques on the caffeoylquinic acids (CQAs) content. The major isomer was 3-CQA, accounting for about 50% of the total CQAs, followed by 5-CQA and 4-CQA, accounting for about 24–36% for each one. The total content of CQAs was in the range of 45.79 to 1662.01 mg/L, found in iced cappuccino and pod espresso, respectively. In conclusion, this study demonstrates that coffee brews, in particular those prepared using pressurized methods, can be considered as the potential sources of antioxidants such as CQAs.
[Objective] To establish a method for determining contents of chlorogenic acid in different organs from Taraxacum mongolicum by HPLC.[Method] The HPLC was carried out with Shim-pack VP-ODS column(4.6 mm×150.0 mm,5 μm) using mixture of methanol and 0.4 % phosphoric acid solution in different ratio as mobile phase.Other conditions were: flow rate of 1.0 ml/min,detection wavelength of 326 nm,column temperature of 40 ℃ and sampling amount of 20 μl.[Result] When the concentration of chlorogenic acid ranged from 0.791 2 to 79.120 0 μg/ml,the linear relationship between concentration and peak area was good(r=0.999 8).The recovery was 98.00%-101.50%.Leaves、roots、flowers and scapes of Taraxacum mongolicum were 1.212,0.536,0.448 and 0.417 mg/g in chlorogenic acid,respectively.[Conclusion] The method established in this work was a rapid and accurate method for determining chlorogenic acid from Taraxacum mongolicum.Leaf of Taraxacum mongolicum was highest in chlorogenic acid,which provided basis for
TABLE-US-00003 TABLE 3 Polyphenol compound Basic substance Metals salt Comp. Example 4 Gallic acid Bleacher -- Example 10 Gallic acid Bleacher magnesium chloride Comp. Example 5 (+)-catechin Sodium hydroxide -- Example 11 (+)-catechin Sodium hydroxide magnesium chloride Comp. Example 6 α G rutin Lye -- Example 12 α G rutin Lye magnesium chloride Comp. Example 7 Caffeic acid brine -- Example 13 Caffeic acid brine magnesium chloride Comp. Example 8 green tee extract sodium hydrogen -- carbonate Example 14 green tee extract sodium hydrogen magnesium chloride carbonate Comp. Example 9 Coffee raw bean extract sodium hydroxide -- Example 15 Coffee raw bean extract sodium hydroxide magnesium chloride Comp. Example 10 Apple extract sodium hydroxide -- Example 16 Apple extract sodium hydroxide magnesium chloride Comp. Example 11 Grape pericarp extract sodium hydrogen -- carbonate Example 17 Grape pericarp extract sodium hydrogen bittern carbonate Comp. Example 12 Peppermint extract brine -- Example 18 ...
1,7-bis(3,4-dihydroxyphenyl)hepta-4E,6E-dien-3-one, 1,8-cineole, 2,3,7-trihydroxy-5-(3,4-dihydroxy-E-styryl)-6,7,8,9-tetrahydro-5H-benzocycloheptene, acetyl terpineol, Aframomum, Alnus-cardamom, alpha-terpinyl acetate, Amomum, Amomum cardamomum, Amomum tsao-ko Crevost et Lemaire, Amomum villosum Lour., amooman, bai dou kou, bari ilaichi (Urdu), bastard cardamom, black cardamom, buah pelaga (Malay), caffeic acid, cardamom oil, cardamom seed, cardamome (French), Cardamomi fructus, cardamomo (Italian, Spanish), cardamon, cardamone (Italian), Cardomomi fructus, chhoti elachi (Hindi), chlorogenic acid, cinnamic acid, elaichi (Hindi), elam (Tamil), Elettaria cardamomum spp., enasal (Sinhalese), ferulic acid, gallic acid, grains of paradise, grawahn (Thai), greater cardamom, green cardamom, heel kalan, Indian cardamom, kapulaga (Indonesian), Kardamom (German), kardamomma (Icelandic), kravan (Thai), large cardamom, lesser cardamom, limonene, linalool, linalyl acetate, Malabar cardamom, minerals, ...
This study was performed to evaluate the in vitro antioxidant and antimicrobial activities and the polyphenolic content of Lycium barbarum L. and L. chinense Mill. leaves. The different leave extracts contain important amounts of flavonoids (43.73 ± 1.43 and 61.65 ± 0.95 mg/g, respectively) and showed relevant antioxidant activity, as witnessed by the quoted methods. Qualitative and quantitative analyses of target phenolic compounds were achieved using a HPLC-UV-MS method. Rutin was the dominant flavonoid in both analysed species, the highest amount being registered for L. chinense. An important amount of chlorogenic acid was determined in L. chinense and L. barbarum extracts, being more than twice as high in L. chinense than in L. barbarum. Gentisic and caffeic acids were identified only in L. barbarum, whereas kaempferol was only detected in L. chinense. The antioxidant activity was evaluated by DPPH, TEAC, hemoglobin ascorbate peroxidase activity inhibition (HAPX) and inhibition of lipid
Polylactic acid (PLA) is a bio-based and biodegradable polymer that has gained a lot more interest in the packaging industry because of environmental concerns and decreasing prices. However, PLA as a food packaging material has some problems like the high oxygen permeability as oxygen causes lipid oxidation of the food product. Preventing this process is usually done by adding synthetic antioxidants (AOs) to the food but these AOs are toxic and could even be carcinogenic. Natural AOs present in plants are therefore a good alternative. By mixing plants with the PLA, an active packaging material could be obtained and less amounts of AOs need to be added to the food. Active packaging films were prepared by adding 3 wt% of dry or lyophilized (lyo) plants of white tea, borage, thyme and rosemary to PLA. Also, model antioxidant films (butylated hydroxytoluene, caffeic acid, epigallocatechin gallate and rosmarinic acid) with 1.5 wt% were solution casted.. The films were migration tested at 37°C for 10 ...
The formation of furam and certain volatiles related to furan formation mechanisms was studied using gas chromatography-mass spectrometry combined with solid-phase micro extraction after adding dicarbonyl trapping agents [epicatechin (EC), epigallocatechin gallate (EGCG), and catechin] water-soluble antioxidants (Trolox, caffeic acid, ferulic acid, and chlorogenic acid), fat-soluble antioxidants (e-tocopherol, BHT, and beta-carotene), and reducing agents (glutathione and sodium sulfite) to canned-coffee model systems (CMS). The level of furan formation decreased significantly following the addition of EC (by 65.3%), EGCG (by 60.0%), and catechin (by 44.7%). In addition, the formation of Maillard reaction products, including furan derivatives (furfural and 5-methylfurfural), Strecker aldehyde (2-methylbutanal), pyrazines (2,6-dimethylpyrazine), and lipid oxidation products (including hexanal and 2-pentylfuran) was suppressed when any of the dicarbonyl trapping agents was added. Among the ...

Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3...Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3...

Ji-Yeon Lee, Hee-Jung Choi, Tae-Wook Chung, Cheorl-Ho Kim, Han-Sol Jeong, Ki-Tae Ha, Caffeic Acid Phenethyl Ester Inhibits ... S1. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4+ T cells. CD4+ T cells (106 cells/ml) were ... S2. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4+ T cells. CD4+ T cells (106 cells/ml) ... S5. Caffeic acid phenethyl ester (CAPE) induces active caspase-3 expression in polarized T helper type 1 (Th1) and Th2 cells. ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2009.04067.x/abstract

Caffeic acid phenethyl ester | CAS 104594-70-9 | SCBT - Santa Cruz BiotechnologyCaffeic acid phenethyl ester | CAS 104594-70-9 | SCBT - Santa Cruz Biotechnology

Caffeic acid phenethyl ester is Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Cited in ... Caffeic acid phenethyl ester Citazioni prodotti Vedi quanti altri hanno usato Caffeic acid phenethyl ester. Clicca sulla voce ... CAPE (Caffeic acid phenethyl ester) is a constituent of the propolis of honeybee hives and has been shown to contain inhibitory ... Caffeic acid phenethyl ester (CAS 104594-70-9) *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
more infohttps://www.scbt.com/it/p/caffeic-acid-phenethyl-ester-104594-70-9

Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in...Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in...

Mohamed MM Abdel-Latif, Henry J Windle, Basma S El Homasany, Kamal Sabra, Dermot Kelleher, `Caffeic acid phenethyl ester ... Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in ... Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in ... Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti- ...
more infohttp://www.tara.tcd.ie/xmlui/handle/2262/33813

Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats? |...Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats? |...

Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats? ... Background: To investigate the effects of propofol and caffeic acid phenethyl ester (CAPE) on prevention of lung injury as a ...
more infohttps://avesis.bezmialem.edu.tr/yayin/395c27b9-b9cc-4e35-800d-1e57bef95418/does-propofol-or-caffeic-acid-phenethyl-ester-prevent-lung-injury-after-hindlimb-ischaemia-reperfusion-in-ventilated-rats

Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic AcidSynthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid

A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to ... Both heterocycle esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against ... further structural modification by electrooxidation of the catechol ring of caffeic acid esters in the presence of sodium ... Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, ...
more infohttp://ijpr.sbmu.ac.ir/article_1355.html

Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via...Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via...

Lin, H. P., Lin, C. Y., Huo, C., Hsiao, P. H., Su, L. C., Jiang, S. S., ... Chuu, C. P. (2015). Caffeic acid phenethyl ester ... Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell ... Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell ... Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell ...
more infohttps://tmu.pure.elsevier.com/en/publications/caffeic-acid-phenethyl-ester-induced-cell-cycle-arrest-and-growth

Frontiers | Current Understanding of the Correlation of Lignin Structure with Biomass Recalcitrance | ChemistryFrontiers | Current Understanding of the Correlation of Lignin Structure with Biomass Recalcitrance | Chemistry

... caffeic acid O -methyltransferase; DAP, dilute acid pretreatment; HCT, hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl ... 2010). Digestibility of silages in relation to their hydroxycinnamic acid content and lignin composition. J. Sci. Food Agric. ... Moxley, G., Gaspar, A. R., Higgins, D., and Xu, H. (2012). Structural changes of corn stover lignin during acid pretreatment. J ... Yeh, T.-F., Chang, M.-J., and Chang, W.-J. (2014). Comparison of dilute acid and sulfite pretreatments on acacia confusa for ...
more infohttps://www.frontiersin.org/articles/10.3389/fchem.2016.00045/full

Human Metabolome Database: Showing metabocard for Chlorogenic acid (HMDB0003164)Human Metabolome Database: Showing metabocard for Chlorogenic acid (HMDB0003164)

Chlorogenic acid. Description. Chlorogenic acid is an ester of caffeic acid and quinic acid. Chlorogenic acid is the major ... Lafay S, Morand C, Manach C, Besson C, Scalbert A: Absorption and metabolism of caffeic acid and chlorogenic acid in the small ... Kang J, Liu Y, Xie MX, Li S, Jiang M, Wang YD: Interactions of human serum albumin with chlorogenic acid and ferulic acid. ... Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid. The chlorogenic acid content of ...
more infohttp://www.hmdb.ca/metabolites/HMDB03164

Echinacea (Echinacea angustifolia, Echinacea pallida, Echinaceapurpurea) - Vitamin LifeEchinacea (Echinacea angustifolia, Echinacea pallida, Echinaceapurpurea) - Vitamin Life

... caffeic acid derivatives, caffeoyl derivatives, cichoric acid and polysaccharides, cock-up-hat, combflower, compositae, cynarin ... dodeca-2E,4E,8Z,10Z(E)-tetraenoic acid isobutylamide, dodecanoic acid derivatives, EC31J0, Echinacea (Strong Nature, Serbia), ... 10-diynoic acid isobutylamide, undecanoic acid derivatives, unsaturated N-alkylamide lipids. ... Use of multivitamins, folic acid and herbal supplements among breast cancer survivors: the black womens health study. BMC. ...
more infohttp://www.livingnaturally.com/ns/DisplayMonograph.asp?storeID=15F522D98A3A417FBE8D6702F135785A&DocID=bottomline-echinacea

Medical attributes of Echinacea spp. - ConeflowersMedical attributes of Echinacea spp. - Coneflowers

The most important caffeic acid derivatives include cichoric acid, chlorogenic acid, cynarin, and echinacoside. Echinacoside, ... caffeic acid derivatives, essential oils, polyacetylenes, alkylamides, and miscellaneous chemicals. In general, the water- ... which breaks down the intracellular cement called hyaluronic acid (Anon. 1997a). ...
more infohttp://klemow.wilkes.edu/Echinacea.html

Echinacea species - Purple coneflowerEchinacea species - Purple coneflower

Constituents: Caffeic acid esters including echinacoside and cichoric acid; alkylamides, mostly unsaturated isobutyl amides ( ... including dodeca-2,4,8,10-tetraenoic acid); polysaccharides (including echinacin B); polyacetylenes; essential oil 1 ...
more infohttp://spiraeaherbs.ca/echinacea-species-purple-coneflower/

What is it? / Echinacea spp / Herbal products / CAM-CancerWhat is it? / Echinacea spp / Herbal products / CAM-Cancer

... caffeic acid and related compounds such as cynarine, echinacosides, chlorogenic acid, chicoric acid.1,2,3 The amount of each of ... Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of ...
more infohttp://ws.cam-cancer.org/The-Summaries/Herbal-products/Echinacea-spp/What-is-it

Caffeic acid, TBDMSCaffeic acid, TBDMS

Other names: Caffeic acid, O,O-bis(tert-butyldimethylsilyl)-, tert-butyldimethylsilyl ester; Caffeic acid, 3TBDMS derivative ... Caffeic acid, TBDMS. *Formula: C27H50O4Si3 ...
more infohttp://webbook.nist.gov/cgi/inchi/InChI%3D1S/C27H50O4Si3/c1-25

Caffeic acid phenethyl ester - WikipediaCaffeic acid phenethyl ester - Wikipedia

Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. It is the ester of caffeic acid and phenethyl ... Huang MT, Smart RC, Wong CQ, Conney AH (November 1988). "Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ... August 2008). "CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human ... Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB (August 1996). "Caffeic acid phenethyl ester is a potent and specific ...
more infohttps://en.wikipedia.org/wiki/Caffeic_acid_phenethyl_ester

Caffeic Acid | GreenMedInfo | Substance | Natural MedicineCaffeic Acid | GreenMedInfo | Substance | Natural Medicine

This topic has 11 study abstracts on Caffeic Acid indicating that it may have therapeutic value in the treatment of Breast ... Caffeic acid and caffeic acid phenethyl ester induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.Sep 14, ... Caffeic acid and caffeic acid phenethyl ester Induction of cell cycle arrest and apoptotic response of head and neck squamous ... A comparison of the migration rate inhibition of breast cancer cells treated by caffeic acid and caffeic acid phenethyl ester. ...
more infohttps://www.greenmedinfo.com/substance/caffeic-acid

Molecules | Free Full-Text | Caffeic Acid Derivatives from Eupatorium perfoliatum L.Molecules | Free Full-Text | Caffeic Acid Derivatives from Eupatorium perfoliatum L.

Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid ... and 3,5-dicaffeoylquinic acid, three up to now unknown depsides of caffeic acid with glucaric acid have been isolated: 2,5- ... dicaffeoylglucaric acid, 3,4-dicaffeoylglucaric acid, and 2,4- or 3,5-dicaffeoylglucaric acid. ... six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. ...
more infohttp://www.mdpi.com/1420-3049/14/1/36

Caffeic Acid Phenethyl Ester Regulates PPARs Levels in Stem Cells-Derived AdipocytesCaffeic Acid Phenethyl Ester Regulates PPAR's Levels in Stem Cells-Derived Adipocytes

Caffeic Acid Phenethyl Ester Regulates PPARs Levels in Stem Cells-Derived Adipocytes. Luca Vanella,1 Daniele Tibullo,2 Justyna ... Luca Vanella, Daniele Tibullo, Justyna Godos, et al., "Caffeic Acid Phenethyl Ester Regulates PPARs Levels in Stem Cells- ...
more infohttps://www.hindawi.com/journals/ppar/2016/7359521/cta/

Table 2 | Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical StrainsTable 2 | Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains

Antimicrobial Potential of Caffeic Acid against,i, Staphylococcus aureus,/i, Clinical Strains ... caffeic acid.. : minimum inhibitory concentration.. : erythromycin.. ICs changes according to the formula [(MIC of antibiotic ... Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains. Table 2. Antibacterial potential of ... caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus. The combined effect of CA ...
more infohttps://www.hindawi.com/journals/bmri/2018/7413504/tab2/

IJMS | Free Full-Text | Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid AnaloguesIJMS | Free Full-Text | Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues

A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited ... Keywords: anti-inflammatory; caffeic acid amides; synthesis; pharmacophore; target predication anti-inflammatory; caffeic acid ... A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited ... Liu Z, Fu J, Shan L, Sun Q, Zhang W. Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues ...
more infohttp://www.mdpi.com/1422-0067/15/5/8808

Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic AcidInhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid

... and tannic acid. ... Substances : Caffeic Acid : CK(43) : AC(25), Tannic Acid : CK(36) : AC(28) ... Previously, we reported that coffee extract and its constituents, caffeic acid (CA) and p-coumaric acid, inhibit infection by ... Inhibition mechanisms of hepatitis C virus infection by caffeic acid and tannic acid. - GreenMedInfo Summary ...
more infohttps://www.greenmedinfo.com/article/inhibition-mechanisms-hepatitis-c-virus-infection-caffeic-acid-and-tannic-acid

Caffeic Acids
     Summary Report | CureHunterCaffeic Acids Summary Report | CureHunter

A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. ... Caffeic Acids. Subscribe to New Research on Caffeic Acids A class of phenolic acids related to chlorogenic acid, p-coumaric ... Carboxylic Acids: 83*Carbocyclic Acids*Cinnamates: 10*Caffeic Acids: 5*Eugenol: 291 ... 01/01/2012 - "Gallic acid and caffeic acids are reported to modulate allergic reactions via unknown mode(s) of action. ". ...
more infohttp://www.curehunter.com/public/keywordSummaryD002109.do

Caffeic and rosmarinic acids in thyme speciesCaffeic and rosmarinic acids in thyme species

... anti-inflammatory and immunomodulating properties of rosmarinic acid. Characteristics of the parameters of optimal extraction ... Caffeic and rosmarinic acids in thyme species. Analysis of the study of antioxidant, anti-inflammatory and immunomodulating ... properties of rosmarinic acid. Characteristics of the parameters of optimal extraction of biologically active compounds of ...
more infohttps://revolution.allbest.ru/languages/00729766_0.html

TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall...TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall...

Bout S, Vermerris W (2003) A candidate-gene approach to clone the sorghum brown midrib gene encoding caffeic acid O- ... Transcription activator-like effector nucleases Genome editing Caffeic acid O-methyltransferase Lignin Sugarcane Capillary ... 2016). Here, we report TALEN mediated targeted mutagenesis of the lignin biosynthetic gene, caffeic acid O-methyltransferase ( ... TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall ...
more infohttps://link.springer.com/article/10.1007/s11103-016-0499-y

Caffeic acid rich Citrus macroptera peel powder supplementation prevented oxidative stress, fibrosis and hepatic damage in CCl4...Caffeic acid rich Citrus macroptera peel powder supplementation prevented oxidative stress, fibrosis and hepatic damage in CCl4...

... vanillic acid, rosmarinic acid, myricetin (4 μg/ml each), caffeic acid, Syringic acid, vanillin, trans-ferulic acid (3 μg/ml ... vanillic acid (VA), caffeic acid (CA), Syringic acid (SA), (−)-epicatechin (EC), vanillin (VL), p-coumaric acid (PCA), trans- ... Peaks: 1, caffeic acid; 2, syringic acid; 3, (−)-epicatechin; 4, vanillin; 5, benzoic acid; 6, kaempferol ... caffeic acid and syringic acid and benzoic acid. This study also pointed out that oxidative stress can be reduced by Citrus ...
more infohttps://link.springer.com/article/10.1186/s40816-018-0074-y

Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats.Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats.

5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to ... The absorption and metabolism in the small intestine of chlorogenic acid ( ... 0/Antioxidants; 0/Caffeic Acids; 0/Coumaric Acids; 0/Hydroxybenzoic Acids; 29656-58-4/phenolic acid; 327-97-9/Chlorogenic Acid ... Caffeic Acids / metabolism*, pharmacokinetics. Chlorogenic Acid / metabolism*, pharmacokinetics. Coumaric Acids / ...
more infohttp://www.biomedsearch.com/nih/Absorption-metabolism-caffeic-acid-chlorogenic/16869989.html
  • The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed or hydrolysed in the small intestine. (biomedsearch.com)
  • In sum, phenolic acid effects on the membrane are enhanced in cholesterol-rich lo phases, which predominate in the outer leaflet of human cell membranes and are involved in many key cellular processes. (ovid.com)
  • In sum, phenolic acid effects on the membrane are enhanced in cholesterol-rich l o phases, which predominate in the outer leaflet of human cell membranes and are involved in many key cellular processes. (ovid.com)
  • Lipid bilayer partition depends on phenolic acid structure and membrane cholesterol. (ovid.com)
  • Caffeine and caffeic acid suppressed the growth of ER + ( P ≤ 0.01) and ER − ( P ≤ 0.03) cells. (aacrjournals.org)
  • The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER + and ER − breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth. (aacrjournals.org)
  • Mechanistically, this study shows that predominantly caffeine, but also caffeic acid, mimics the actions of antiestrogens and modifies major growth regulatory pathways ER/cyclin D1 and IGFIR/pAkt, resulting in impaired cell-cycle progression and reduced cellular proliferation. (aacrjournals.org)
  • In the present report, we identified another coffee-related compound, tannic acid (TA), which also inhibits HCV infection. (greenmedinfo.com)
  • Capillary electrophoresis with electrochemical detection has been employed for the determination of p-hydroxyacetophenone, chlorogenic acid, and caffeic acid in Herba Artemisiae Scopariae (the dried sprout of Artemisia scoparia Waldst. (ebscohost.com)
  • Detection of Chlorogenic Acid in Honeysuckle Using Infrared-Assisted Extraction Followed by Capillary Electrophoresis with UV Detector. (ebscohost.com)
  • In this study, a novel infrared-assisted extraction method coupled capillary electrophoresis (CE) is employed to determine chlorogenic acid from a traditional Chinese medicine (TCM), honeysuckle. (ebscohost.com)
  • Determination of uric acid in human saliva by capillary electrophoresis with electrochemical detection: potential application in fast diagnosis of gout. (ebscohost.com)
  • Short-chain fatty acid formation in the hindgut of rats fed native and fermented oat fibre concentra. (biomedsearch.com)
  • Here we deploy transcription activator-like effector nuclease (TALEN) to induce mutations in a highly conserved region of the caffeic acid O-methyltransferase ( COMT ) of sugarcane. (springer.com)
  • Phenolic acids have been associated to a wide range of important health benefits underlain by a common molecular mechanism of action. (ovid.com)
  • Thus, the current investigation showed caffeic acid to exert carcinogenic activity for the forestomach squamous cell epithelium in both sexes of F344 rats and C57BL/6N × C3H/HeN F 1 mice, for the renal tubular cell in male rats and female mice, and for the alveolar type II cell in male mice. (aacrjournals.org)