Caenorhabditis elegans Proteins
Caenorhabditis elegans
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Caenorhabditis
Amino Acid Sequence
Sequence Homology, Amino Acid
Vulva
Mutation
Animals, Genetically Modified
RNA, Helminth
Disorders of Sex Development
In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.
Base Sequence
Cloning, Molecular
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Phenotype
Nematoda
Embryo, Nonmammalian
Larva
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Pharynx
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Transcription Factors
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Oviposition
Conserved Sequence
Locomotion
Genes, Lethal
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Alleles
Membrane Proteins
Chromosome Mapping
Antinematodal Agents
GATA Transcription Factors
Hermaphroditic Organisms
Meiosis
Models, Biological
Luminescent Proteins
Gene Expression Regulation
Molting
Periodic casting off FEATHERS; HAIR; or cuticle. Molting is a process of sloughing or desquamation, especially the shedding of an outer covering and the development of a new one. This phenomenon permits growth in ARTHROPODS, skin renewal in AMPHIBIANS and REPTILES, and the shedding of winter coats in BIRDS and MAMMALS.
Recombinant Fusion Proteins
DNA, Complementary
Levamisole
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Morphogenesis
Neurons
Pharyngeal Muscles
The muscles of the PHARYNX are voluntary muscles arranged in two layers. The external circular layer consists of three constrictors (superior, middle, and inferior). The internal longitudinal layer consists of the palatopharyngeus, the salpingopharyngeus, and the stylopharyngeus. During swallowing, the outer layer constricts the pharyngeal wall and the inner layer elevates pharynx and LARYNX.
Nervous System
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Evolution, Molecular
Genome
Suppression, Genetic
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. (1/5831)
We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type sma genes. Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to lon mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions. Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. (+info)Alzheimer's disease: clues from flies and worms. (2/5831)
Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked. (+info)The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family. (3/5831)
In the Caenorhabditis elegans hermaphrodite germ line, the sex-determining gene fem-3 is repressed posttranscriptionally to arrest spermatogenesis and permit oogenesis. This repression requires a cis-acting regulatory element in the fem-3 3' untranslated region; the FBF protein, which binds to this element; and at least six mog genes. In this paper, we report the molecular characterization of mog-1 as well as additional phenotypic characterization of this gene. The mog-1 gene encodes a member of the DEAH-box family. Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous. The MOG-1 DEAH-box protein is most closely related to proteins essential for splicing in the yeast Saccharomyces cerevisiae, but splicing appears to occur normally in a mog-1-null mutant. In addition to its involvement in the sperm-oocyte switch and control of fem-3, zygotic mog-1 is required for robust germ line proliferation and for normal growth during development. We suggest that mog-1 plays a broader role in RNA regulation than previously considered. (+info)Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination. (4/5831)
A recA-like gene was identified in the Caenorhabditis elegans genome project database. The putative product of the gene, termed Ce-rdh-1 (C. elegans RAD51 and DMC1/LIM15 homolog 1), consists of 357 amino acid residues. The predicted amino acid sequence of Ce-rdh-1 showed 46-60% identity to both RAD51 type and DMC1/LIM15 type genes in several eukaryote species. The results of RNAi (RNA-mediated interference) indicated that repression of Ce-rdh-1 blocked chromosome condensation of six bivalents and dissociation of chiasmata in oocytes of F1 progeny. Oogenesis did not proceed to the diakinesis stage. Accordingly, all the eggs produced (F2) died in early stages. These results suggest that Ce-rdh-1 participates in meiotic recombination. (+info)The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. (5/5831)
The Caenorhabditis elegans HSN motor neurons permit genetic analysis of neuronal development at single-cell resolution. The egl-5 Hox gene, which patterns the posterior of the embryo, is required for both early (embryonic) and late (larval) development of the HSN. Here we show that ham-2 encodes a zinc finger protein that acts downstream of egl-5 to direct HSN cell migration, an early differentiation event. We also demonstrate that the EGL-43 zinc finger protein, also required for HSN migration, is expressed in the HSN specifically during its migration. In an egl-5 mutant background, the HSN still expresses EGL-43, but expression is no longer down-regulated at the end of the cell's migration. Finally, we find a new role in early HSN differentiation for UNC-86, a POU homeodomain transcription factor shown previously to act downstream of egl-5 in the regulation of late HSN differentiation. In an unc-86; ham-2 double mutant the HSNs are defective in EGL-43 down-regulation, an egl-5-like phenotype that is absent in either single mutant. Thus, in the HSN, a Hox gene, egl-5, regulates cell fate by activating the transcription of genes encoding the transcription factors HAM-2 and UNC-86 that in turn individually control some differentiation events and combinatorially affect others. (+info)Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5. (6/5831)
The Caenorhabditis elegans body axis, like that of other animals, is patterned by the action of Hox genes. In order to examine the function of one C. elegans Hox gene in depth, we determined the postembryonic expression pattern of egl-5, the C. elegans member of the Abdominal-B Hox gene paralog group, by means of whole-mount staining with a polyclonal antibody. A major site of egl-5 expression and function is in the epithelium joining the posterior digestive tract with the external epidermis. Patterning this region and its derived structures is a conserved function of Abd-B paralog group genes in other animals. Cells that initiate egl-5 expression during embryogenesis are clustered around the presumptive anus. Expression is initiated postembryonically in four additional mesodermal and ectodermal cell lineages or tissues. Once initiated in a lineage, egl-5 expression continues throughout development, suggesting that the action of egl-5 can be regarded as defining a positional cell identity. A variety of cross-regulatory interactions between egl-5 and the next more anterior Hox gene, mab-5, help define the expression domains of their respective gene products. In its expression in a localized body region, function as a marker of positional cell identity, and interactions with another Hox gene, egl-5 resembles Hox genes of other animals. This suggests that C. elegans, in spite of its small cell number and reproducible cell lineages, may not differ greatly from other animals in the way it employs Hox genes for regional specification during development. (+info)Merbarone, a catalytic inhibitor of DNA topoisomerase II, induces apoptosis in CEM cells through activation of ICE/CED-3-like protease. (7/5831)
Merbarone (5-[N-phenyl carboxamido]-2-thiobarbituric acid) is an anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes. Although the cytotoxicity of the complex-stabilizing DNA-topo II inhibitors such as VP-16 (etoposide) has been partially elucidated, the cytotoxicity of merbarone is poorly understood. Here, we report that merbarone induces programmed cell death or apoptosis in human leukemic CEM cells, characterized by internucleosomal DNA cleavage and nuclear condensation. Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase. Treatment of CEM cells with a potent inhibitor of caspases, Z-Asp-2. 6-dichlorobenzoyloxymethyl-ketone, inhibited merbarone-induced caspase-3/CPP32-like activity and apoptosis in a dose-dependent manner. These results indicate that the catalytic inhibition of topo II by merbarone leads to apoptotic cell death through a caspase-3-like protease-dependent mechanism. These results further suggest that c-Jun and c-Jun NH2-terminal kinase/stress-activated protein kinase signaling may be involved in the cytotoxicity of merbarone. (+info)Interaction of 5-lipoxygenase with cellular proteins. (8/5831)
5-Lipoxygenase (5LO) plays a pivotal role in cellular leukotriene synthesis. To identify proteins interacting with human 5LO, we used a two-hybrid approach to screen a human lung cDNA library. From a total of 1.5 x 10(7) yeast transformants, nine independent clones representing three different proteins were isolated and found to specifically interact with 5LO. Four 1.7- to 1.8-kb clones represented a 16-kDa protein named coactosin-like protein for its significant homology with coactosin, a protein found to be associated with actin in Dictyostelium discoideum. Coactosin-like protein thus may provide a link between 5LO and the cytoskeleton. Two other yeast clones of 1.5 kb encoded transforming growth factor (TGF) type beta receptor-I-associated protein 1 partial cDNA. TGF type beta receptor-I-associated protein 1 recently has been reported to associate with the activated form of the TGF beta receptor I and may be involved in the TGF beta-induced up-regulation of 5LO expression and activity observed in HL-60 and Mono Mac 6 cells. Finally, three identical 2.1-kb clones contained the partial cDNA of a human protein with high homology to a hypothetical helicase K12H4. 8 from Caenorhabditis elegans and consequently was named DeltaK12H4. 8 homologue. Analysis of the predicted amino acid sequence revealed the presence of a RNase III motif and a double-stranded RNA binding domain, indicative of a protein of nuclear origin. The identification of these 5LO-interacting proteins provides additional approaches to studies of the cellular functions of 5LO. (+info)
A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity | Science
Search Articles | University of Toronto Libraries
TumorPortal
The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in...
The dve-1 gene and its possible relation to ageing in roundworms
Positioning edgetic residues in CED-9 structures. (a) P | Open-i
Implications of sequencing the nematode Caenorhabditis elegans genome for plant nematology
Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed...
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5<...
Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline | Genetics
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. | Genetics
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation - Infoscience
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation. - Oxford...
Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes | Science
DIGITAL.CSIC: Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline | Development
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
Altered expression of an L1-specific, O-linked cuticle surface glycoprotein in mutants of the nematode Caenorhabditis elegans. ...
On the nature of undead cells in the nematode Caenorhabditis elegans | Philosophical Transactions of the Royal Society B:...
The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal...
The role of insulin/IGF-like signaling in C. elegans longevity and aging. | Lewis-Sigler Institute
Serotonin-deficient Mutants and Male Mating Behavior in the Nematode Caenorhabditis Elegans - PubMed
An evidence-based approach to identify aging-related genes in Caenorhabditis elegans | BMC Bioinformatics | Full Text
IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans | EMBO Reports
Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology.
Caenorhabditis elegans MIG-13 protein
Summary Report | CureHunter
C. elegans** homologs of insect clock proteins: a tale of many stories - Institutional Repository University of Antwerp
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans - NASA/ADS
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans - CSHL Scientific Digital Repository
foxo;Pi3K92E
CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation |...
EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans | Nature Cell Biology
Genetic and molecular analysis of a Caenorhabditis elegans beta-tubulin that conveys benzimidazole sensitivity. | JCB
A semi-automated system based on level sets and invariant spatial interrelation shape features for Caenorhabditis elegans...
VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans | Development
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.
Fermented Brown Sugar Residue Prolongs the Caenorhabditis elegans Lifespan via DAF-16
A compendium of Caenorhabditis elegans RNA binding proteins predicts e by Alex M. Tamburino, Sean P. Ryder et al.
The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. -...
Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
Aging and resistance to oxidative damage in Caenorhabditis elegans | PNAS
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo | Journal of Cell Biology |...
Reliable CRISPR/Cas9 Genome Engineering in Caenorhabditis elegans Using a Single Efficient sgRNA and an Easily Recognizable...
The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval...
The C. elegans Male:Postembryonic Development of Nongonadal Structures
Developmental regulation of Caenorhabditis elegans DNA topoisomerase I expression<...
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to...
Origin, properties, and regulated expression of multiple mRNAs encoded by the protein kinase C1 gene of Caenorhabditis elegans<...
Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory...
Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and...
The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for...
QTL mapping for Caenorhabditis elegans survivorship in response to Escherichia coli and Stenotrophomonas maltophilia
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans | DR-NTU
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors<...
RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans | Journal...
Vulval development (Caenorhabditis elegans) - WikiPathways
Vulval development (Caenorhabditis elegans) - WikiPathways
Regulation of Tcl transposable elements in Caenorhabditis elegans.<...
Two Leucobacter strains exert complementary virulence on Caenorhabditis including death by worm-star formation. - Oxford...
Cytoplasmic flow and the establishment of polarity in C. elegans 1-cell embryos. - Semantic Scholar
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans : ubiquitin-conjugating enzymes,...
Family of FLP peptides in Caenorhabditis elegans and related nematodes by Chris Li and Kyuhyung Kim
Frontiers | Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans | Genetics
Navigational choice between reversal and curve during acidic pH avoidance behavior in Caenorhabditis elegans | BMC Neuroscience...
Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain | PNAS
lin-12 - Protein lin-12 precursor - Caenorhabditis elegans - lin-12 gene & protein
Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3 | The EMBO Journal
Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. - Semantic Scholar
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback - White Rose Research Online
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by...
OSA | Multiphoton laser scanning microscopy for four-dimensional analysis of Caenorhabditis elegans embryonic development.
MicroRNA targeting in mus musculus and Caenorhabditis elegans
Molecular and genetic characterization of GON-2, a TRPM cation channel required for gonadogenesis in Caenorhabditis elegans. ::...
Caenorhabditis elegans as an environmental monitor using DNA microarray analysis<...
PRIME PubMed | Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity
Hubers Killi-Data - Aphyosemion elegans, information snapshot (Cyprinodontiformes, Killifishes)
Sel-12
The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. ... a Caenorhabditis elegans S182 Alzheimer's disease gene". Nature. 377 (6547): 351-354. Bibcode:1995Natur.377..351L. doi:10.1038/ ... sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly). C. elegans ... Stefan Eimer (2003). "Analysis and suppression of mutant sel-12 in C. elegans". Ph.D. Thesis, Ludwig-Maximilians Universität, ...
Crustacean neurohormone family
Caenorhabditis elegans uncharacterised protein ZC168.2. These neurohormones are peptides of 70 to 80 amino acid residues which ... In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. The ...
FERM domain
Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E. Caenorhabditis elegans protein phosphatase ptp-1. Chishti ... Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is ... In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein ... Non-receptor tyrosine-protein kinase TYK2. Protein-tyrosine phosphatases PTPN3 and PTPN4, enzymes that appear to act at ...
Immunoglobulin C2-set domain
Chothia C, Teichmann SA (2000). "Immunoglobulin superfamily proteins in Caenorhabditis elegans". J. Mol. Biol. 296 (5): 1367-83 ... "Protein-Protein Recognition: Juxtaposition of Domain and Interface Cores in Immunoglobulins and Other Sandwich-like Proteins". ... This article incorporates text from the public domain Pfam and InterPro: IPR008424 (Protein pages needing a picture, Protein ... Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. ...
Ced-12
Protein pages needing a picture, Caenorhabditis elegans genes). ... containing adaptor protein found in Caenorhabditis elegans and ... Researchers also noted direct protein-protein interactions between CED-12 and CED-10 (C. elegans homolog for Rac1), a Rac- ... The first is by CED-6, which is an adaptor protein that is responsible for coordinating protein-protein interactions between ... It is found on chromosome 2 on the L-arm in Drosophila, and on chromosome I in C. elegans. The protein structure of CED-12 is ...
Ced-9
"ced-9 - Apoptosis regulator ced-9 - Caenorhabditis elegans - ced-9 gene & protein". www.uniprot.org. Retrieved 2017-11-16. ... Protein pages needing a picture, Caenorhabditis elegans genes). ... The CED-9 protein belongs to the Bcl-2-like protein family. ... The protein is homologous to the human apoptotic regulator Bcl-2 as well as all other proteins in the Bcl-2 protein family. CED ... elegans. The protein consists of 280 amino acids and has a molecular weight of 31824.42 Da. The structure of this protein has ...
Ced-5
Protein pages needing a picture, Caenorhabditis elegans genes). ... elegans phagocytosis and cell-migration protein CED-5 is ... CED-5 is an ortholog of the mammalian protein Dock180,which present in the nematode worm C. elegans., the Drosophila ...
Ced-3
... is one of the major protein components of the programmed cell death (PCD) pathway for Caenorhabditis elegans. There are ... "ced-3 Cell death protein 3 [ Caenorhabditis elegans ]". The National Center for Biotechnology Information. 2017-10-12. Shaham S ... elegans but for mammals as well. One of the main roles of the ced-3 protein in C. elegans is to help the development and growth ... "Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4". FEBS Letters. 406 (1-2): 189- ...
Epistasis and functional genomics
"Lin-26 Transcription factor lin-26 [Caenorhabditis elegans] - Gene - NCBI". "Lin-36 Protein lin-36 [Caenorhabditis elegans] - ... Data from protein-protein interaction studies can also provide a useful basis for selecting gene groups for E-MAP data. We ... and their data demonstrate that an E-MAP approach identifies protein-protein interactions with a specificity equal to that of ... 2007). "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map". ...
Daf-12
Protein pages needing a picture, Caenorhabditis elegans genes, Nuclear receptors). ... in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 (Hr96) in ... "The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting- ... Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. ...
WormBook
Bioinformatics, Biology books, Cell biology, Caenorhabditis elegans, Proteins, Animal developmental biology). ... peer-reviewed chapters covering topics related to the biology of the nematode worm Caenorhabditis elegans (C. elegans). ... Corsi, Ann K. (2015). "A Transparent window into biology: A primer on Caenorhabditis elegans". WormBook: 1-31. doi:10.1895/ ... The C. elegans Sequencing Consortium (1998). "Genome sequence of the nematode C. elegans: A platform for investigating biology ...
Richard I. Morimoto
Prahlad, V; Morimoto, RI (2011). "Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins". ... "Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells". Genes & Development. 21 ... In vivo Properties of the Disaggregase Function of J-domain Proteins and Hsc70 in C. elegans Stress and Aging. Aging Cell 16: ... Prahlad, V.; Cornelius, T.; Morimoto, R.I. (2008). "Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by ...
BED zinc finger
Caenorhabditis elegans Dpy-20 protein, a predicted cuticular gene transcriptional regulator; Drosophila BEAF (boundary element- ... In molecular biology the BED-type zinc finger domain is a protein domain which was named after the Drosophila proteins BEAF and ... Some proteins known to contain a BED domain include animal, plant and fungi AC1 and Hobo-like transposases; ... This article incorporates text from the public domain Pfam and InterPro: IPR003656 (Protein domains). ...
IMD domain
Caenorhabditis elegans M04F3.5 protein. The vertebrate IRSp53/MIM family is divided into two major groups: the IRSp53 subfamily ... Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like ... Vertebrate ABBA-1 (MTSS1L), a MIM-related protein. Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 ( ... a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/ ...
RoGFP
"Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans". Nature Communications ... The reduction-oxidation sensitive green fluorescent protein (roGFP) is a green fluorescent protein engineered to be sensitive ... elegans. In addition, roGFPs are used to investigate the topology of ER proteins, or to analyze the ROS production capacity of ... The resulting engineered protein could exist in two different oxidation states (reduced dithiol or oxidized disulfide), each ...
Vasa gene
"Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins". Genetics. 178 (4): 1973-87. doi:10.1534/ ... The protein product in humans has 724 amino acids, a molecular mass of 79 kDa and 8 conserved domains in all DEAD-box proteins ... Many other proteins in Drosophila are also localized to the poles. For example, oskar protein was found to localize to pole ... Vasa is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. The vasa ...
Galactose binding lectin domain
The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans. Ozeki Y, Matsui T, Suzuki M, Titani K ( ... In molecular biology, the galactose binding lectin domain is a protein domain. It is found in many proteins including the ... homologous to the SUEL protein has been identified in the following proteins: Plant beta-galactosidases EC 3.2.1.23 (lactases ... This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each ...
LITE-1
v t e (All stub articles, Protein stubs, Caenorhabditis elegans genes, Photoreceptor cells). ... LITE-1 is a novel photoreceptor found in Caenorhabditis elegans. It exhibits blue light photoreceptor activity. Is involved in ... Many organisms have photosensitive proteins, yet only two types of photoreceptors, opsins and cryptochromes, have been ... elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor". Cell. 167 (5): 1252-1263.e10. doi:10.1016/j.cell.2016.10.053. ISSN ...
UNC93B1
This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the ... Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene. ... This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum ... Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to ...
RBFOX1
"Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals". Molecular and Cellular ... or hexaribonucleotide-binding protein 1 (HRNBP1) or RNA binding protein, fox-1 homolog (Rbfox1), is a protein that in humans is ... Rbfox1 has an RNA recognition motif that is highly conserved among RNA-binding proteins. Rbfox1, and the related protein Rbfox2 ... "Entrez Gene: A2BP1 ataxin 2-binding protein 1". Jin, Y. (2003-02-17). "A vertebrate RNA-binding protein Fox-1 regulates tissue- ...
NeuN
... a protein which is a homologue to the protein product of a sex-determining gene in Caenorhabditis elegans, is a neuronal ... Underwood JG, Boutz PL, Dougherty JD, Stoilov P, Black DL (2005). "Homologues of the Caenorhabditis elegans Fox-1 protein are ... Fox-3 is one of a family of mammalian homologues of the Fox-1 protein, originally discovered in the nematode worm C. elegans as ... a protein originally identified from genetic studies of the nematode worm C. elegans. Western blotting shows that mAb A60 binds ...
Andrew Dillin
His lab studies the loss of protein homeostasis in aging, particularly in Caenorhabditis elegans. His lab specifically looks at ... the manipulation of stress response pathways, such as the heat shock response and the unfolded protein response of the ...
FHIT
"Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans". Proc. Natl. ... Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by ...
SbRNA
"Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins". BMC ... Li T; He H; Wang Y; Zheng H; Skogerbø G; Chen R (2008). "In vivo analysis of Caenorhabditis elegans noncoding RNA promoter ... sbRNA (stem-bulge RNA) is a family of non-coding RNA first discovered in Caenorhabditis elegans. It was identified during a ... March 2005). "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans". Nature. 434 (7032): 462-9. doi: ...
UNC93A
Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that ... Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene. Unc93A is a major facilitator ... and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The ... Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see: ...
Cell nucleus
"Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans". Primary. BMC ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ... Speckles are dynamic structures, and both their protein and RNA-protein components can cycle continuously between speckles and ... Both structures serve to mediate binding to nuclear transport proteins.: 509-10 Most proteins, ribosomal subunits, and some ...
Gluconeogenesis
"Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle". ... Transport of PEP across the mitochondrial membrane is accomplished by dedicated transport proteins; however no such proteins ... it triggers phosphorylation of enzymes and regulatory proteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in ... In the liver, the FOX protein FOXO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks FOXO6 upon ...
ARL13B
2010). "Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans". J. ... ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein ... This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in the ARL13B ... The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. ...
Daf-8
v t e (Protein pages needing a picture, Caenorhabditis elegans genes, All stub articles, Gene stubs). ... which was originally found in model organism Caenorhabditis elegans. When the TGF-β ligand daf-7 binds to the TGF-β receptors ... Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1-34. doi:10.1895/wormbook.1.22.2. PMC ... The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, ...
Daf-1
Articles with short description, Short description matches Wikidata, Protein pages needing a picture, Caenorhabditis elegans ... the SMAD proteins in C. elegans. Georgi LL, Albert PS, Riddle DL (May 1990). "daf-1, a C. elegans gene controlling dauer larva ... of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". ... Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta ...
Uridine monophosphate synthase
Deficiency of the enzyme can be studied in the model organism Caenorhabditis elegans. The rad-6 strain has a premature stop ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Merry A (2007). Characterisation and Identification of a Radiation Sensitive Mutant in Caenorhabditis elegans (Ph.D.). ... It is believed that the two separate catalytic sites fused into a single protein to stabilize its monomeric form. The covalent ...
WIPI2
2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". ... WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene. WD40 repeat ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a ...
Endless Forms Most Beautiful (book)
... the nematode Caenorhabditis elegans)?" asks Erwin. He answered his own question about the "astonishing morphological diversity ... of their proteins, a figure that rises to 95% for humans and mice. Thus we can't exclude protein-sequence evolution as an ... Most of the changes are in genetic control, not in proteins. 11. Endless Forms Most Beautiful Carroll concludes by revisiting ... which do not code for structural proteins (such as enzymes), control embryonic development. In turn, these regulatory genes ...
Senescence
... ranging from the simple budding yeast Saccharomyces cerevisiae to worms such as Caenorhabditis elegans and fruit flies ( ... Free radicals can damage proteins, lipids or DNA. Glycation mainly damages proteins. Damaged proteins and lipids accumulate in ... Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can ... These adducts can further rearrange to form reactive species, which can then cross-link the structural proteins or DNA to ...
Mitochondrial ribosomal protein L4
2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". ... 39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene. Mammalian mitochondrial ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24 ...
Eileen Southgate
... is a British biologist who mapped the complete nervous system of the roundworm Caenorhabditis elegans (C. ... Southgate initially worked for Max Perutz and John Kendrew studying hemoglobin, the protein responsible for carrying oxygen ... 1986) 'The structure of the nervous system of the nematode Caenorhabditis elegans'". Philosophical Transactions of the Royal ... Ankeny, Rachel A. (June 2001). "The natural history of Caenorhabditis elegans research". Nature Reviews Genetics. 2 (6): 474- ...
Short interspersed nuclear element
"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans". Science. 294 (5543): 858-62. Bibcode: ... Furthermore, SINEs frequently contain motifs for YY1 polycomb proteins. YY1 is a zinc-finger protein that acts as a ... Thereafter, one of the strands is incorporated into a multi-protein RNA-induced silencing complex (RISC). Among these proteins ... encodes a protein which binds to RNA and acts as a chaperone to facilitate and maintain the LINE protein-RNA complex structure ...
SPTAN1
Moorthy S, Chen L, Bennett V (May 2000). "Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial ... Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein ... Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 ... Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. ...
Sex-chromosome dosage compensation
"A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex ... For example, in Caenorhabditis elegans (or C. elegans), sex is determined by the ratio of X chromosomes relative to autosomes; ... elegans. In fact, xol-1 is often referred to in the literature as the master sex regulatory gene of C. elegans. XX C. elegans ... Male specific lethal proteins (MSLs) are a family of four proteins that bind to the X chromosome exclusively in males. The name ...
Microtubule
Chalfie M, Thomson JN (1979). "Organization of neuronal microtubules in the nematode Caenorhabditis elegans". Journal of Cell ... MAP-1 proteins consists of a set of three different proteins: A, B and C. The C protein plays an important role in the ... including the motor proteins dynein and kinesin, microtubule-severing proteins like katanin, and other proteins important for ... Plus end tracking proteins are MAP proteins which bind to the tips of growing microtubules and play an important role in ...
Leonard P. Guarente
Tissenbaum, H.A.; L. Guarente (2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans". Nature. ... In 2000 the Guarente laboratory published work identifying SIR2's activity as a NAD+-dependent protein deacetylase. This NAD ... In round worm, Guarente reported that Caenorhabditis elegans, expression of SIR2 (sir2.1) is sufficient to extend longevity and ... Caenorhabditis elegans), and mice. He is a Novartis Professor of Biology at the Massachusetts Institute of Technology. Leonard ...
Nuclear receptor
There are 270 nuclear receptors in the roundworm Caenorhabditis elegans alone, 21 in the fruit fly and other insects, 73 in ... to nuclear receptors induces a conformation of the receptor that preferentially binds coactivator proteins. These proteins ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. Bibcode: ... Additional proteins including RNA polymerase are then recruited to the NR/DNA complex that transcribe DNA into messenger RNA. ...
Biomolecular condensate
The droplets can also grow to be many molecules across (micrometres) Studies of droplets of the Caenorhabditis elegans protein ... Another example of liquid droplets in cells are the germline P granules in Caenorhabditis elegans. These granules separate out ... In addition to protein recruitment, condensates can also be designed which release proteins in response to certain stimuli. In ... Membrane protein, or membrane-associated protein, clustering at neurological synapses, cell-cell tight junctions, or other ...
BZIP intron RNA motif
... mouse and Caenorhabditis elegans, fruit fly, honey bee, carp, whiteleg shrimp Other Fungi: Trichoderma reesei and Aspergillus ... two proteins involved in the unfolded protein response of Litopenaeus vannamei". Developmental & Comparative Immunology. 38 (1 ... Splicing of the bZIP intron is a key regulatory step in the unfolded protein response (UPR). The Ire-mediated unconventional ... Sidrauski C, Cox JS, Walter P (1996). "tRNA ligase is required for regulated mRNA splicing in the unfolded protein response". ...
Teneurin
Ten-m refers to tenascin-like protein major. Teneurins are highly conserved between Drosophila, C. elegans and vertebrates. In ... the teneurin family is conserved from Caenorhabditis elegans (ten-1) to vertebrates, in which four paralogs exist (teneurin-1 ... and neuronal pathfinding in Caenorhabditis elegans". Developmental Biology. 282 (1): 27-38. doi:10.1016/j.ydbio.2005.02.017. ... The intracellular domains of Ten-a, Ten-m/Odz and C. elegans TEN-1 are significantly different, both in size and structure, ...
Coronin
The coronin-like proteins from budding yeast Crn1 and one of the coronins in Caenorhabditis elegans has a much longer unique ... Caenorhabditis elegans POD-1 and Drosophila coronin homologue regulate the actin cytoskeleton and are involved in vesicular ... Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans. Initially, a 55 kDa protein was ... Initially this protein was admitted into club of actin binding proteins with least enthusiasm, as the primary structure did not ...
Pre-replication complex
Proteolytic regulation of Cdt1 is shared by higher eukaryotes including Caenorhabditis elegans, Drosophila melanogaster, X. ... In most eukaryotes it is composed of six ORC proteins (ORC1-6), Cdc6, Cdt1, and a heterohexamer of the six MCM proteins (MCM2-7 ... There is a stoichiometric excess of the MCM proteins over the ORC and Cdc6 proteins, indicating that there may be multiple MCM ... The ORC4 protein is known to bind the AT-rich portion of the origin of replication in S. pombe using AT hook motifs. The ...
Connectome
Yamamoto, William S.; Achacoso, Theodore B. (1992-06-01). "Scaling up the nervous system of Caenorhabditis elegans: Is one ape ... a combinatorial color labeling method based on the stochastic expression of several fluorescent proteins, Jeff W. Lichtman and ... The first (and so far only) fully reconstructed connectome belongs to the roundworm Caenorhabditis elegans. The major effort ... "The structure of the nervous system of the nematode Caenorhabditis elegans". Philosophical Transactions of the Royal Society of ...
PIKFYVE
"The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans". Molecular Biology ... By directly binding membrane PtdIns(3)P, the FYVE finger domain of PIKfyve is essential in localizing the protein to the ... December 2008). "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63-70. ...
Epigenomics
Some organisms like Caenorhabditis elegans have not been demonstrated to have 5mC nor a conventional DNA methyltransferase; ... Regulatory proteins that bind to DNA, RNA, and/or proteins are key effectors in these processes and function by positively or ... The SWI/SNF protein complex in yeast is one example of a chromatin remodeling complex that regulates the expression of many ... Binding of these proteins recruit histone deacetylases (HDACs) enzyme which initiate chromatin remodeling such that the DNA ...
BioGRID
Caenorhabditis elegans (nematode worm) Candida albicans SC5314 Canis familiaris (dog) Cavia porcellus (guinea pig) ... The BioGRID's original focus was on curation of binary protein-protein and genetic interactions, but has expanded over several ... The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein ... A comprehensive biomedical resource of curated protein, genetic, and chemical interactions". Protein Science. 30 (1): 187-200. ...
Kinesin-like protein KIF11
Bishop JD, Han Z, Schumacher JM (2005). "The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for ... Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene ... "KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene & protein". www.uniprot.org. Retrieved 10 April 2022. ... The unique assembly of Kinesin-5 proteins not only organizes the protein complex for a different cellular function ( ...
Mediator (coactivator)
In both human cells and Caenorhabditis elegans MED15 is involved in lipid homeostasis through the pathway involving SREBPs In ... which may contribute to the conformational flexibility seen both with and without other bound proteins or protein complexes. A ... Fungal-specific Protein-name in Sch. pombe Kelleher RJ, Flanagan PM, Kornberg RD (June 1990). "A novel mediator between ... Micro RNAs are involved in regulating the expression of many proteins. Med1 is targeted by miR-1, which is important in gene ...
Cdc14
The nematode Caenorhabditis elegans makes one Cdc14 (CeCdc14), which localizes to the spindle and centrosomes in mitosis, and ... "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22 (14): 3524-3535. doi: ... "The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo". Journal of Cell Biology. 158 (5): ... Also, while the protein regulates the Cdk1 ortholog of S. pombe, this occurs through a process unlike that of S. cerevisiae; it ...
POU4F1
... and the Caenorhabditis elegans factor Unc86, and named Brn3. When multiple members of the Brn3 gene class were discovered, it ... homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene. BRN3A (POU4F1) is a ... The protein product is still frequently referred to as Brn3a. In addition to sensory neurons, in rodents and birds (and ... POU4F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...
Mechanoreceptor
Driscoll, Monica; Chalfie, Martin (February 1991). "The mec-4 gene is a member of a family of Caenorhabditis elegans genes that ... amiloride-sensitive ion channel protein related to epithelial sodium channels (ENaCs). This protein, called MEC-4, forms a ... Early research showed that touch transduction in the nematode Caenorhabditis elegans was found to require a two transmembrane, ... Mechanoreceptor proteins are ion channels whose ion flow is induced by touch. ...
Vault (organelle)
Caenorhabditis elegans-a free-living nematode that lives in soil. Drosophila melanogaster-a two-winged insect also known as a ... The protein structure consists of an outer shell composed of 78 copies of the ~100 kDa major vault protein (MVP). Inside are ... Proteins and peptides can also be packaged into vaults by attachment of a packaging domain derived from the VPARP protein. A ... The three vault proteins (MVP, VPARP, and TEP1) have each been knocked out individually and in combination (VPARP and TEP1) in ...
CUTC (gene)
2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". ... Copper homeostasis protein cutC homolog is a protein that in humans is encoded by the CUTC gene. GRCh38: Ensembl release 89: ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC". Biochem ...
Rapid Degradation of Caenorhabditis elegans Proteins at Single-Cell Resolution with a Synthetic Auxin
The auxin-inducible degradation system allows for spatial and temporal control of protein degradation via a hormone-inducible , ... Rapid Degradation of Caenorhabditis elegans Proteins at Single-Cell Resolution with a Synthetic Auxin G3 (Bethesda). 2020 Jan 7 ... tagged proteins for proteasomal degradation. Here, we optimize the Caenorhabditis elegans AID system by utilizing 1- ... We provide insight into how the AID system functions in C. elegans by determining that TIR1 depends on C. elegans SKR-1/2, CUL- ...
Changes of Protein Turnover in Aging Caenorhabditis elegans* - Molecular & Cellular Proteomics
The nematode Caenorhabditis elegans (C. elegans). 1. The abbreviations used are: C. elegans, Caenorhabditis elegans; E. coli, ... Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant.. J. Gerontol. ... Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant. ... Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans.. J Proteome Res. 2015; 14: 1483-1494 ...
RCSB PDB - 1PUL: Solution structure for the 21KDa caenorhabditis elegans protein CE32E8.3. NORTHEAST STRUCTURAL GENOMICS...
Solution structure for the 21KDa caenorhabditis elegans protein CE32E8.3. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET WR33 ... Hypothetical protein C32E8.3 in chromosome I. A. 125. Caenorhabditis elegans. Mutation(s): 0 Gene Names: C32E8.3, tppp-1. ... Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans homologue of "brain-specific" protein.. Monleon, D. ... Solution structure for the 21KDa caenorhabditis elegans protein CE32E8.3. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET WR33 ...
HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1 - Institut de Génomique...
Fixation and Immunostaining of Endogenous Proteins or Post-translational Modifications in Caenorhabditis elegans -BIO-PROTOCOL
... elegans ciliated sensory neurons and to detect non-modified endogenous protein (Topalidou and Chalfie, 2011). ... Fluorescently-tagged proteins created by CRISPR genome editing are less prone to defective expression patterns because the loci ... Here, we present a reliable protocol in which C. elegans nematodes are fixed, preserved, and permeabilized for staining with a ... if the fluorescent tag obstructs or otherwise interferes with important protein interaction domains or affects the protein ...
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans | AVESİS
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans ... using Caenorhabditis elegans and mammalian cell culture systems, we investigated the poorly understood ciliary and molecular ... as well as defects in ciliary protein localization and transport; ciliary transmembrane proteins abnormally accumulate, PKD-2 ... The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients ...
IUCr) Acta Crystallographica Section D Volume 60, Part 10, October 2004
Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans. N. Schormann, J. Symersky and M. Luo ... The crystals of recombinant protein expressed in E. coli belong to space group P21212, with unit-cell parameters a = 150.5, b ... YciE protein from E. coli was overexpressed and purified. Crystals of YciE belonged to space group R32 and diffracted to a ... The protein has been crystallized in the orthorhombic space group P2221 and the crystals diffract to 2.7 Å resolution. ...
The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and...
The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and ... The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and ... The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and ... T1 - The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing ...
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the...
A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte...
keywords = "Animals, Caenorhabditis elegans/enzymology, Caenorhabditis elegans Proteins/genetics, Chromatin/metabolism, ... Engert, C. G., Droste, R., van Oudenaarden, A., & Horvitz, H. R. (2018). A Caenorhabditis elegans protein with a PRDM9-like SET ... A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte ... A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte ...
Metabolism
... is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans ... AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a- ... Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells. ... Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein ...
Frontiers | Hemichannel composition and electrical synaptic transmission: molecular diversity and its implications for...
Unapposed hemichannels formed by oligomerized hexamers of gap junction proteins are now known to be involved in various ... formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological ... The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family ... High resolution map of Caenorhabditis elegans gap junction proteins. Dev. Dyn. 238, 1936-1950. doi: 10.1002/dvdy.22025 ...
Biblio | Journal of Alzheimer's Disease
Caenorhabditis elegans Proteins. T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D. ... Repressor Proteins. T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D., X Liu, S., ... DNA-Binding Proteins. T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D., X Liu, S. ...
Kindler epidermolysis bullosa: MedlinePlus Genetics
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes ... This gene provides instructions for making a protein known as kindlin-1. This protein is found in epithelial cells, which are ... Most variants in the FERMT1 gene prevent the production of any functional kindlin-1. A lack of this protein disrupts many ... Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and ...
positive regulation of hypodermal cell differentiation | Semantic Scholar
Category:Chromatin - Wikimedia Commons
LeptoteneZygotene-Chromosome-Movement-Via-the-SUNKASH-Protein-Bridge-in-Caenorhabditis-elegans-pgen.1001219.s014.ogv 12 s, 656 ... Histone-H3.3-Variant-Dynamics-in-the-Germline-of-Caenorhabditis-elegans-pgen.0020097.sv001.ogv 1 min 0 s, 1,024 × 512; 1.91 MB ... Histone-H3.3-Variant-Dynamics-in-the-Germline-of-Caenorhabditis-elegans-pgen.0020097.sv002.ogv 6.7 s, 1,024 × 512; 783 KB. ... Nuclear-Pore-Proteins-Nup153-and-Megator-Define-Transcriptionally-Active-Regions-in-the-Drosophila-pgen.1000846.s017.ogv 7.2 s ...
The SensorOverlord predicts the accuracy of measurements with ratiometric biosensors | Scientific Reports
Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans. Nat. Commun. 5, 5020. ... These protein networks can be understood as markets where cysteines in proteins buy (reduction) and sell (oxidation) pairs of ... Cannon, M. B. & Remington, S. J. Re-engineering redox-sensitive green fluorescent protein for improved response rate. Protein ... We predicted the EGSH inaccuracy that we would observe if we measured EGSH in the feeding muscles of live C. elegans with the ...
Sol Genomics Network
Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans". Reactome:REACT_34592 "G alpha (i) auto- ... heterotrimeric G-protein GTPase activity NARROW heterotrimeric G-protein GTPase, alpha-subunit RELATED heterotrimeric G-protein ... protein-synthesizing GTPase activity NARROW protein-synthesizing GTPase activity, elongation NARROW protein-synthesizing GTPase ... "protein-synthesizing GTPase activity" NARROW [] "protein-synthesizing GTPase activity, elongation" NARROW [] "protein- ...
Thomas M. Roberts, PhD - Dana-Farber Cancer Institute | Boston, MA
2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. J Mol Biol. ... Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP ... Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science. 1994 Oct 07; 266(5182):126-9.. View in: PubMed. ... The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens ...
spp-12 gene cDNA ORF clone, Caenorhabditis elegans - GenScript
Next-day shipping cDNA ORF clones derived from spp-12 SaPosin-like Protein family available at GenScript, starting from $99.00. ... spp-12 ( NM_074042.1 ) cDNA ORF clone, Caenorhabditis elegans -, NP_506443.1 Caenorhabditis elegans SaPosin-like Protein family ... Caenorhabditis elegans -, NP_506443.1 Caenorhabditis elegans Saposin B-type domain-containing protein (spp-12), mRNA. ... Caenorhabditis elegans Saposin B-type domain-containing protein (spp-12), mRNA.. pcDNA3.1-C-(k)DYK or customized vector. 9-11. ...
Lai F et al. (2012),
Xenopus Nanos1 is required to prevent endoderm ... -
Paper
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. 1999, Pubmed Bouwmeester, Cerberus is a head- ... A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. 1997, Pubmed Zhang, The ... Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3 untranslated region. 1991, Pubmed ... Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3 untranslated region. 1991, Pubmed ...
Fabio Piano
Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.. ... A protein domain-based interactome network for C. elegans early embryogenesis.. Cell (2008 Aug 8) PMC2596478 free full-text ... A model of cytoplasmically driven microtubule-based motion in the single-celled Caenorhabditis elegans embryo.. Proc Natl Acad ... mRNA capping enzyme requirement for Caenorhabditis elegans viability.. J Biol Chem (2003 Apr 18) PMID: 12576475. Srinivasan P, ...
Anti-6X His tag® antibody [4D11] (ab5000) | Abcam
Stephens AD et al. Isolation and Imaging of His- and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and ... Proteins and Peptides. By product type. Proteomics tools. Agonists, activators, antagonists and inhibitors. Cell lines and ... The H-H-H-H-H-H motif is used as a tag on many recombinant proteins to facilitate purification. His-tags can be fused to the ... Beta3-His fusion protein was immunoprecipitated using anti His Ab, and specific beta3a band (56kDa) was detected using anti ...
Neurotree - Ann Rougvie
2006) Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42. Developmental Biology. 289: 30 ... 2014) Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. Proceedings of the ... 2016) Analysis of a lin-42/Period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and ... 2010) miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. Developmental ...
Sandwalk: September 2008
The latest estimate is 20,140 protein coding genes in the Caenorhabditis elegans genome. The coding regions (exons) would take ... Protein interactions will not be solved by proteomics or protein chips but by protein biochemistry. The genome sequences tell ... The Pristionchus pacificus genome is 169 Mb in size, which is considerably larger than the size of the Caenorhabditis elegans ... The free-living species Caenorhabditis elegans was chosen by Sydney Brenner as a model organism for the study of development [ ...
Vitamin E Does Not Cause Prostate Cancer | Baseline of Health Foundation
Noble Research Lab: Publications and software
"Visualization and dissemination of multidimensional proteomics data comparing protein abundance during Caenorhabditis elegans ... "Learning to predict protein-protein interactions from protein sequences." Bioinformatics (Proceedings of the Georgia Tech ... "Protein interaction networks: protein domain interaction and protein function prediction." In Handbook of Statistical ... "Protein ranking: from local to global structure in the protein similarity network." Proceedings of the National Academy of ...
NematodeGenes2018GenomeGermlineSpeciesTransgenicStrains2016ChromatinNematodesHomologDrosophilaRegulationSoluble and membrane proteinsGreen fluoresLifespanRegulatesMammalianTargeted protein degradationMolecular BiologyMutationIntrinsically disorderedRNAsIsoformsDegradationBiologyAmino AcidsClonesCellularMoleculesKinaseDynamicsExperimentsDomain-containMembrane-proteinNspsAlpha-synucleinHomeostasisRibonucleoproteinRNAiActin cytoskeletonBindTubulinWormsStructuralSubunitVivoTransmembrane proteinModelDevelopmentDomainsDefectsGeneticInteractExpression
Nematode7
- Genome sequence of the nematode C. elegans: a platform for investigating biology. (genscript.com)
- The nematode C. elegans can take up Moco from its bacterial diet and transport it to cells and tissues that express Moco-requiring enzymes, suggesting a system for Moco uptake and distribution," noted the investigators. (genengnews.com)
- We tested four proteins and all four were restorative in our nematode model. (genengnews.com)
- Proteins from the nematode species CAENORHABDITIS ELEGANS . (bvsalud.org)
- We developed efficient procedures for targeted, heritable disruption of genes and cis-acting regulatory elements in the model nematode Caenorhabditis elegans and applied them to C. briggsae , a species diverged by 15 to 30 million years. (bioseek.eu)
- Using the nematode Caenorhabditis elegans they show that the inheritance of small RNAs antisense to histone genes adversely affect the fertility of worms across generations until they become sterile. (pasteur.fr)
- However, in the nematode Caenorhabditis elegans piRNA mutants are initially fertile and become sterile only after many generations. (pasteur.fr)
Genes6
- To better understand the tissue-specific regulation of chromatin state in cell-fate determination and animal development, we defined the tissue-specific expression of all 36 C. elegans presumptive lysine methyltransferase (KMT) genes using single-molecule fluorescence in situ hybridization (smFISH). (knaw.nl)
- Resnick T, Malmquist S, Rougvie A. ( 2009 ) Developmental timing genes identified through miRNA suppressor screens in C. elegans Developmental Biology . (neurotree.org)
- The discovery of specific genes and proteins associated with AD, and the development of new technologies for the production of transgenic animals, has helped researchers to overcome the lack of natural models. (springer.com)
- Their study, " Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans, " is published in the journal Genes and Development . (genengnews.com)
- The researchers investigated the interactions between the transcription factor DAF-16 and the genes that regulate the production of an insulin-like growth factor 1 (IGF-1-like) protein related to the development, reproduction, and aging in C. elegans. (asu.edu)
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (smpdb.ca)
20181
- Care4Rare Canada Consortium, Boycott KM, Bastin P and Sheridan EG (2018) Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects. (sfu.ca)
Genome8
- Fluorescently-tagged proteins created by CRISPR genome editing are less prone to defective expression patterns because the loci retain endogenous DNA elements that regulate their transcription (Nance and Frøkjær-Jensen, 2019). (bio-protocol.org)
- Therefore, our data can be used not only to analyze the C. elegans genome but also to guide the functional examination of the human genome. (nyu.edu)
- We have recently sequenced the genome of a parthogenetic relative of C. elegans that shows an alternate pattern of early cleavages. (nyu.edu)
- Recent advances in genome editing have expedited the precise insertion of fluorescent protein tags into the genomes of diverse organisms. (cam.ac.uk)
- Check out our detailed JoVE protocol and accompanying video walkthrough for genome editing with CRISPR-Cas9 RNPs in primary human HSPCs and T cells, Caenorhabditis elegans , and Parhyale hawaiensis . (innovativegenomics.org)
- 2] Dickinson DJ, And Goldstein B. (2016) CRISPR-based methods for Caenorhabditis elegans genome engineering. (wormbook.org)
- 4] Paix A, Kolkmann A, Rasoloson D, and Seydoux G. (2015) High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9 ribonucleoprotein complexes. (wormbook.org)
- Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
Germline5
- We found that the germline-expressed C. elegans protein SET-17, which has a SET domain similar to that of the PRDM9 and PRDM7 SET-domain proteins, promotes fertility by regulating gene expression in primary spermatocytes. (knaw.nl)
- Developmental dynamics of gene expression and alternative polyadenylation in the Caenorhabditis elegans germline. (nyu.edu)
- Now, on p. 4975 , Boag and co-workers report that a conserved RNA-protein (RNP)complex regulates germline apoptosis in Caenorhabditis elegans . (biologists.com)
- They identify a germline RNA-binding protein, CAR-1 (for cytokinesis/apoptosis/RNA binding), and show that it associates with the RNA helicase CGH-1 in an RNA-dependent manner within a germline RNP complex. (biologists.com)
- LOTUS and Tudor domain containing proteins have critical roles in the germline. (bvsalud.org)
Species3
- Significantly, in some species the wild-type patterns of early embryonic cell divisions resemble those produced by various C. elegans mutants, indicating plasticity in the underlying molecular networks. (nyu.edu)
- Here we show that protein-bound Moco is the stable, bioavailable species of Moco taken up by C. elegans from its diet and is an effective dietary supplement, rescuing a C. elegans model of Moco deficiency. (genengnews.com)
- The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS . (bvsalud.org)
Transgenic3
- We generated transgenic Caenorhabditis elegans strains expressing green, yellow, or red fluorescent proteins in embryos and imaged embryos expressing different fluorescent proteins under the same conditions for direct comparison. (cam.ac.uk)
- Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI. (harvard.edu)
- We developed a fluorescence-based in vivo assay using transgenic Caenorhabditis elegans worms that express the green fluorescent protein (GFP) under the control of various CYP promoters. (who.int)
Strains1
- Isolated Desulfovibrio strains were fed to a strain of Caenorhabditis elegans roundworms that expressed human alpha-syn fused with yellow fluorescent protein. (medscape.com)
20161
- 2016 ) Analysis of a lin-42/Period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing. (neurotree.org)
Chromatin1
- SET-17 is concentrated in stable chromatin-associated nuclear foci at actively transcribed msp (major sperm protein) gene clusters, which we term msp locus bodies. (knaw.nl)
Nematodes3
- Here, we present a reliable protocol in which C. elegans nematodes are fixed, preserved, and permeabilized for staining with a primary antibody to bind proteins or post-translational modifications, which are then labeled with a secondary antibody conjugated to a fluorescent dye. (bio-protocol.org)
- We study the genetic and evolutionary mechanisms underlying early embryonic development using a combination of molecular genetic and functional genomics approaches in the animal model C. elegans and related nematodes. (nyu.edu)
- In 2003, molecular biology and genetics researchers Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon conducted an experiment that investigated the cellular aging in, Caenorhabditis elegans (C. elegans) nematodes. (asu.edu)
Homolog3
- Kindlin-1 is a human homolog of the Caenorhabditis elegans protein UNC-112, a membrane-associated structural/signaling protein that had been implicated in linking the actin cytoskeleton to the extracellular matrix (ECM). (medscape.com)
- 2014 ) Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. (neurotree.org)
- They bind and anchor the Vasa homolog GLH-1 within P granules and are jointly required for coalescence of MEG-3, GLH-1, and PGL proteins. (bvsalud.org)
Drosophila2
- Proteins that contain these domains, such as Tejas/Tapas in Drosophila, help localize the Vasa helicase to the germ granules and facilitate piRNA-mediated transposon silencing. (bvsalud.org)
- We show here that AIP associates with AhR homologues from mouse and fish, which can bind ligands such as dioxin, but nonligand binding homologues from Caenorhabditis elegans or Drosophila do not bind to AIP. (cdc.gov)
Regulation2
- In C. elegans, aex-4 is involved in positive regulation of defecation and positive regulation of protein secretion. (wormbase.org)
- a ) Glutathione redox potential ( E GSH ) directs the oxidation of cysteines in hundreds of proteins in the same direction, resulting in their concerted regulation. (nature.com)
Soluble and membrane proteins1
- Jensen VL and Leroux MR (2017) Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment. (sfu.ca)
Green fluores1
- Using an unc-2 promoter-tagged green fluorescent protein construct, we show that unc-2 is primarily expressed in motor neurons, several subsets of sensory neurons, and the HSN and VC neurons that control egg laying. (jneurosci.org)
Lifespan3
- Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water-participation of Pt nanoparticles. (h2bev.com)
- electrolyzed reduced water prolongs caenorhabditis elegans lifespan , in Animal Cell Technology: Basic & Applied Aspects . (h2bev.com)
- Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water. (h2bev.com)
Regulates4
- Together, these data implicate a role for JS-associated Arl13b at ciliary membranes, where it regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability. (agu.edu.tr)
- 2010 ) The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues. (neurotree.org)
- Interestingly, KLHL21 but not KLHL22 is necessary for cytokinesis and regulates translocation of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase, similar to the previously described BTB-Kelch proteins KLHL9 and KLHL13. (rupress.org)
- The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. (harvard.edu)
Mammalian3
- In this study, using Caenorhabditis elegans and mammalian cell culture systems, we investigated the poorly understood ciliary and molecular basis of Arl13b function. (agu.edu.tr)
- The Caenorhabditis elegans unc-2 gene encodes a voltage-gated calcium channel α 1 subunit structurally related to mammalian dihydropyridine-insensitive high-threshold channels. (jneurosci.org)
- In this study, we identify two mammalian BTB (Bric-a-brac-Tramtrack-Broad complex)-Kelch proteins, KLHL21 and KLHL22, that interact with Cul3 and are required for efficient chromosome alignment. (rupress.org)
Targeted protein degradation1
- We also demonstrate that K-NAA, the water-soluble, potassium salt of NAA, can be combined with microfluidics for targeted protein degradation in C. elegans larvae. (nih.gov)
Molecular Biology1
- Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. (elsevier.com)
Mutation1
- Purified AIP binds to the C terminus of hsp90, and mutation of a conserved basic residue in the tetratricopeptide repeats of AIP (K266A, analogous to K97A in protein phosphatase 5) abolishes binding to hsp90. (cdc.gov)
Intrinsically disordered1
- We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. (bvsalud.org)
RNAs2
- 2010 ) miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. (neurotree.org)
- Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. (harvard.edu)
Isoforms2
- Multicellular organisms express multiple ADF/cofilin isoforms in a tissue-specific manner, and the vertebrate proteins are grouped into ADFs and cofilins on the basis of their biochemical activity. (elsevier.com)
- Here, we show that the two Caenorhabditis elegans ADF/cofilin isoforms exhibit different activities for severing and depolymerizing actin filaments. (elsevier.com)
Degradation4
- The auxin-inducible degradation system allows for spatial and temporal control of protein degradation via a hormone-inducible Arabidopsis F-box protein, transport inhibitor response 1 (TIR1). (nih.gov)
- In the presence of auxin, TIR1 serves as a substrate-recognition component of the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), ubiquitinating auxin-inducible degron (AID)-tagged proteins for proteasomal degradation. (nih.gov)
- We take advantage of the photostability of NAA to demonstrate via quantitative high-resolution microscopy that rapid degradation of target proteins can be detected in single cells within 30 min of exposure. (nih.gov)
- Finally, we present highly penetrant defects from NAA-mediated degradation of the FTZ-F1 nuclear hormone receptor, NHR-25, during C. elegans uterine-vulval development. (nih.gov)
Biology1
- We develop new tools in structural biology, namely MicroED as a new method for cryo EM, to facilitate the study of such membrane proteins to atomic resolution from vanishingly small crystals. (janelia.org)
Amino Acids1
- I think there were only forty-five amino acids [the building blocks of proteins] that were in insulin. (elizabethdzeng.com)
Clones2
- Repositorio consejería de sanidad de madrid: Interplay among Resistance Profiles, High-Risk Clones, and Virulence in the Caenorhabditis elegans Pseudomonas aeruginosa Infection Model. (repositoriosaludmadrid.es)
- In this work, we attempted to decipher the interplay between resistance profiles, high-risk clones, and virulence, testing a large (n = 140) collection of well-characterized P. aeruginosa isolates from different sources (bloodstream infections, nosocomial outbreaks, cystic fibrosis, and the environment) in a Caenorhabditis elegans infection model. (repositoriosaludmadrid.es)
Cellular5
- The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations to maintain a proper energy balance in cells. (jbc.org)
- The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic hub regulating various pathways involved in tumor metabolism. (jbc.org)
- Unapposed hemichannels (HCs) formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological and pathological conditions. (frontiersin.org)
- Brenner won the Nobel Prize for establishing Caenorhabditis elegans, a type of roundworm, as the model organism for cellular and developmental biological research, which led to discoveries in organ development and programmed cell death. (elizabethdzeng.com)
- As a result, we found proteins that are involved in important processes during development, such as energy metabolism, control pathways and cellular communication. (cdc.gov)
Molecules3
- Kindlin-1 is involved in several important cell functions, including cell growth and division (proliferation), the attachment of cells to the underlying network of proteins and other molecules (cell-matrix adhesion), and the movement (migration) of cells. (medlineplus.gov)
- This code is the process by which cells in our body translate information stored in our DNA into proteins, vital molecules important to the structure and functioning of cells. (elizabethdzeng.com)
- Other in silico methods that are routinely used in research laboratories include molecular modelling (a technique used to model or mimic the structure of molecules) and protein sequencing and its alignment (methods used to evaluate identities and similarities in the amino acid sequence of proteins) [25-28]. (biomedscis.com)
Kinase2
- The structure of the regulatory subunit of the protein kinase CK2 crystallized in the presence of p21 WAF1 suggests binding in the solvent-accessible part of the zinc-finger motif. (iucr.org)
- Cdk2, Cell division protein kinase 2 (EC 2.7.1. (reactome.org)
Dynamics4
- However, limited information is available on turnover dynamics at the individual protein level during aging. (mcponline.org)
- Although these proteins are biochemically distinct and play different roles in actin dynamics, they all appear to use the ADF-H domain for their interactions with actin. (embl.de)
- Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. (embl.de)
- Fluorescent protein tags are fundamental tools used to visualize gene products and analyze their dynamics in vivo. (cam.ac.uk)
Experiments4
- Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
- These advances expand the potential of in vivo imaging experiments and facilitate experimentation with new, bright, photostable fluorescent proteins. (cam.ac.uk)
- We found that mNeonGreen was not as bright in vivo as predicted based on in vitro data but is a better tag than GFP for specific kinds of experiments, and we report on optimal red fluorescent proteins. (cam.ac.uk)
- These results identify ideal fluorescent proteins for imaging in vivo in C. elegans embryos and suggest good candidate fluorescent proteins to test in other animal model systems for in vivo imaging experiments. (cam.ac.uk)
Domain-contain3
- and Thrombospondin type-1 domain-containing protein 1. (wormbase.org)
- Caenorhabditis elegans Saposin B-type domain-containing protein (spp-12), mRNA. (genscript.com)
- Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. (smpdb.ca)
Membrane-protein2
- In situ serial crystallography for rapid de novo membrane protein structure determination. (psi.ch)
- Both proteins form a complex with synaptobrevin, an intrinsic membrane protein of SVs. (uni-bielefeld.de)
Nsps3
- Following the entry into the host cell, SARS-CoV-2 replication is mediated by the replication transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps). (bvsalud.org)
- The in vitro incorporation of AHA with different tags into newly synthesized proteins (NSPs) by PSCs was analyzed using SDS-PAGE and confocal microscopy. (cdc.gov)
- The LC-MS/MS analysis of AHA-labeled NSPs by PSCs undergoing strobilation allowed for the identification of 365 proteins, of which 75 were differentially expressed in comparison between the presence or absence of strobilation stimuli and 51 were expressed exclusively in either condition. (cdc.gov)
Alpha-synuclein2
- A common gut bacteria may play a role in the development of Parkinson's disease (PD) by causing aggregation of the alpha-synuclein protein, a key feature in the pathology of PD, a small study suggests. (medscape.com)
- Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. (wehaveparkinsons.com)
Homeostasis3
- Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. (elsevier.com)
- Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. (elsevier.com)
- Our laboratory studies the structures of membrane proteins important in homeostasis and signaling. (janelia.org)
Ribonucleoprotein1
- We propose that these proteins serve as scaffolds and organizing centers for ribonucleoprotein networks within P granules that help recruit and balance essential RNA processing machinery to regulate key developmental transitions in the germ line. (bvsalud.org)
RNAi2
- One of the main tools we have used is RNA interference (RNAi) followed by time-lapse microscopy to work toward a comprehensive molecular description of early embryogenesis in C. elegans . (nyu.edu)
- For example, expression of a constitutively active form of a tagged protein or knockdown of a target by RNAi can simulate the effects of a sought-after small molecule in a screen. (nih.gov)
Actin cytoskeleton1
- Actin depolymerizing factors (ADF) are stimulus responsive actin cytoskeleton modulating proteins. (embl.de)
Bind2
- Tamoxifen itself doesn't bind to the estradiol receptor protein, instead it is converted inside your body to other chemicals that do bind. (blogspot.com)
- This binding is thought to be responsible for vesicle docking and apparently precedes membrane fusion, According to the current concept, syntaxin 1 and SNAP-25 are members of larger protein families, collectively designated as target-SNAP receptors (t-SNAREs), whose specific localization to subcellular membranes define where transport vesicles bind and fuse, Here we demonstrate that major pools of syntaxin 1 and SNAP-25 recycle with SVs. (uni-bielefeld.de)
Tubulin3
- 2020) to preserve and detect post-translational modifications of tubulin in C. elegans ciliated sensory neurons and to detect non-modified endogenous protein (Topalidou and Chalfie, 2011). (bio-protocol.org)
- We have identified a remarkable complex of proteins associated with a third type of tubulin, gamma-tubulin. (stanford.edu)
- Gamma-tubulin and its associated proteins are localized to the centrosome and are critical for initiation, or nucleation, of microtubule assembly. (stanford.edu)
Worms1
- The research team observed that the worms could take in Moco as a range of purified Moco-protein complexes. (genengnews.com)
Structural2
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
- The proteins responsible for the key molecular events leading to the structural changes between the developmental stages of Echinococcus granulosus remain unknown. (cdc.gov)
Subunit1
- The α 1 subunit forms the voltage-sensor and channel proper, whereas the remaining proteins interact with the α 1 subunit to modulate channel activity. (jneurosci.org)
Vivo4
- Comparative assessment of fluorescent proteins for in vivo imaging in an animal model system. (cam.ac.uk)
- To address the gap, we quantitatively assessed fluorescent protein properties in vivo in an animal model system. (cam.ac.uk)
- The Caenorhabditis elegans hermaphrodite germ line provides a simple and accessible system for studying stem cells in vivo In this system, GLP-1/Notch activity prevents the differentiation of distal germ cells in response to ligand production from the nearby distal tip cell, thereby supporting a stem cell pool. (bvsalud.org)
- IMSEAR at SEARO: Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. (who.int)
Transmembrane protein1
- Fas ligand is a transmembrane protein part of the tumor necrosis factor (TNF) family. (smpdb.ca)
Model4
- Consistent with previous data, we documented a clear inverse correlation between antimicrobial resistance and virulence in the C. elegans model. (repositoriosaludmadrid.es)
- The highest virulence of ST235 could be attributed to its exoU+ type III secretion system (TTSS) genotype, which was found to be linked with higher virulence in our C. elegans model. (repositoriosaludmadrid.es)
- Other markers, such as motility or pigment production, were not essential for virulence in the C. elegans model but seemed to be related with the higher values of the statistical normalized data. (repositoriosaludmadrid.es)
- In contrast to ST235, the ST175 high-risk clone, which is widespread in Spain and France, seems to be associated with a particularly low virulence in the C. elegans model. (repositoriosaludmadrid.es)
Development6
- Together, this work improves our use and understanding of the AID system for dissecting gene function at the single-cell level during C. elegans development. (nih.gov)
- C. elegans deficient in Moco also die very early in development. (genengnews.com)
- I had originally intended to ask him about Professor Frederick Sanger, the two-time Nobel Prize winner famous for his discovery of the structure of proteins and his development of DNA sequencing methods, who passed away in November. (elizabethdzeng.com)
- In this work, azidohomoalanine (AHA)-specific labeling was used to identify proteins expressed by E . granulosus protoscoleces (PSCs) upon the induction of strobilar development. (cdc.gov)
- After the controlled-labeling of proteins during the induction of strobilar development, we identified modifications in protein expression. (cdc.gov)
- We used different protein tags that allowed for the visualization and purification of proteins produced specifically after the induction of strobilar development to identify proteins that might be involved in this process (temporally controlled and context-dependent). (cdc.gov)
Domains3
- However, even CRISPR alleles encoding heritable fluorescently-tagged protein markers can result in defects in function or localization of the gene product if the fluorescent tag obstructs or otherwise interferes with important protein interaction domains or affects the protein structure. (bio-protocol.org)
- There are 9609 ADF domains in 8060 proteins in SMART's nrdb database. (embl.de)
- Until now, proteins containing both LOTUS and Tudor domains in Caenorhabditis elegans have remained elusive. (bvsalud.org)
Defects1
- 2005 ) Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects. (neurotree.org)
Genetic2
- This abnormal construction has been linked to genetic mutations in a family of proteins called collapsin response mediator proteins (CRMPs). (truman.edu)
- ED: Today, the structure of DNA and how genetic information is translated into proteins are established scientific canon, but in the 1950s, the hypotheses generated at the LMB were dismissed as inconceivable nonsense. (elizabethdzeng.com)
Interact1
- The aryl hydrocarbon receptor (AhR) has been shown to interact with an immunophilin-like molecule known as AhR-interacting protein (AIP) and to enhance AhR function. (cdc.gov)
Expression2
- GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
- The estrogen receptor is a protein that binds to DNA to increase (activate) or decrease (repress) gene expression. (blogspot.com)