Caenorhabditis elegans Proteins
Caenorhabditis elegans
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Caenorhabditis
Amino Acid Sequence
Sequence Homology, Amino Acid
Vulva
Mutation
Animals, Genetically Modified
RNA, Helminth
Disorders of Sex Development
In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.
Base Sequence
Cloning, Molecular
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Phenotype
Nematoda
Embryo, Nonmammalian
Larva
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Pharynx
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Transcription Factors
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Oviposition
Conserved Sequence
Locomotion
Genes, Lethal
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Alleles
Membrane Proteins
Chromosome Mapping
Antinematodal Agents
GATA Transcription Factors
Hermaphroditic Organisms
Meiosis
Models, Biological
Luminescent Proteins
Gene Expression Regulation
Molting
Periodic casting off FEATHERS; HAIR; or cuticle. Molting is a process of sloughing or desquamation, especially the shedding of an outer covering and the development of a new one. This phenomenon permits growth in ARTHROPODS, skin renewal in AMPHIBIANS and REPTILES, and the shedding of winter coats in BIRDS and MAMMALS.
Recombinant Fusion Proteins
DNA, Complementary
Levamisole
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Morphogenesis
Neurons
Pharyngeal Muscles
The muscles of the PHARYNX are voluntary muscles arranged in two layers. The external circular layer consists of three constrictors (superior, middle, and inferior). The internal longitudinal layer consists of the palatopharyngeus, the salpingopharyngeus, and the stylopharyngeus. During swallowing, the outer layer constricts the pharyngeal wall and the inner layer elevates pharynx and LARYNX.
Nervous System
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Evolution, Molecular
Genome
Suppression, Genetic
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. (1/5831)
We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type sma genes. Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to lon mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions. Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. (+info)Alzheimer's disease: clues from flies and worms. (2/5831)
Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked. (+info)The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family. (3/5831)
In the Caenorhabditis elegans hermaphrodite germ line, the sex-determining gene fem-3 is repressed posttranscriptionally to arrest spermatogenesis and permit oogenesis. This repression requires a cis-acting regulatory element in the fem-3 3' untranslated region; the FBF protein, which binds to this element; and at least six mog genes. In this paper, we report the molecular characterization of mog-1 as well as additional phenotypic characterization of this gene. The mog-1 gene encodes a member of the DEAH-box family. Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous. The MOG-1 DEAH-box protein is most closely related to proteins essential for splicing in the yeast Saccharomyces cerevisiae, but splicing appears to occur normally in a mog-1-null mutant. In addition to its involvement in the sperm-oocyte switch and control of fem-3, zygotic mog-1 is required for robust germ line proliferation and for normal growth during development. We suggest that mog-1 plays a broader role in RNA regulation than previously considered. (+info)Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination. (4/5831)
A recA-like gene was identified in the Caenorhabditis elegans genome project database. The putative product of the gene, termed Ce-rdh-1 (C. elegans RAD51 and DMC1/LIM15 homolog 1), consists of 357 amino acid residues. The predicted amino acid sequence of Ce-rdh-1 showed 46-60% identity to both RAD51 type and DMC1/LIM15 type genes in several eukaryote species. The results of RNAi (RNA-mediated interference) indicated that repression of Ce-rdh-1 blocked chromosome condensation of six bivalents and dissociation of chiasmata in oocytes of F1 progeny. Oogenesis did not proceed to the diakinesis stage. Accordingly, all the eggs produced (F2) died in early stages. These results suggest that Ce-rdh-1 participates in meiotic recombination. (+info)The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. (5/5831)
The Caenorhabditis elegans HSN motor neurons permit genetic analysis of neuronal development at single-cell resolution. The egl-5 Hox gene, which patterns the posterior of the embryo, is required for both early (embryonic) and late (larval) development of the HSN. Here we show that ham-2 encodes a zinc finger protein that acts downstream of egl-5 to direct HSN cell migration, an early differentiation event. We also demonstrate that the EGL-43 zinc finger protein, also required for HSN migration, is expressed in the HSN specifically during its migration. In an egl-5 mutant background, the HSN still expresses EGL-43, but expression is no longer down-regulated at the end of the cell's migration. Finally, we find a new role in early HSN differentiation for UNC-86, a POU homeodomain transcription factor shown previously to act downstream of egl-5 in the regulation of late HSN differentiation. In an unc-86; ham-2 double mutant the HSNs are defective in EGL-43 down-regulation, an egl-5-like phenotype that is absent in either single mutant. Thus, in the HSN, a Hox gene, egl-5, regulates cell fate by activating the transcription of genes encoding the transcription factors HAM-2 and UNC-86 that in turn individually control some differentiation events and combinatorially affect others. (+info)Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5. (6/5831)
The Caenorhabditis elegans body axis, like that of other animals, is patterned by the action of Hox genes. In order to examine the function of one C. elegans Hox gene in depth, we determined the postembryonic expression pattern of egl-5, the C. elegans member of the Abdominal-B Hox gene paralog group, by means of whole-mount staining with a polyclonal antibody. A major site of egl-5 expression and function is in the epithelium joining the posterior digestive tract with the external epidermis. Patterning this region and its derived structures is a conserved function of Abd-B paralog group genes in other animals. Cells that initiate egl-5 expression during embryogenesis are clustered around the presumptive anus. Expression is initiated postembryonically in four additional mesodermal and ectodermal cell lineages or tissues. Once initiated in a lineage, egl-5 expression continues throughout development, suggesting that the action of egl-5 can be regarded as defining a positional cell identity. A variety of cross-regulatory interactions between egl-5 and the next more anterior Hox gene, mab-5, help define the expression domains of their respective gene products. In its expression in a localized body region, function as a marker of positional cell identity, and interactions with another Hox gene, egl-5 resembles Hox genes of other animals. This suggests that C. elegans, in spite of its small cell number and reproducible cell lineages, may not differ greatly from other animals in the way it employs Hox genes for regional specification during development. (+info)Merbarone, a catalytic inhibitor of DNA topoisomerase II, induces apoptosis in CEM cells through activation of ICE/CED-3-like protease. (7/5831)
Merbarone (5-[N-phenyl carboxamido]-2-thiobarbituric acid) is an anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes. Although the cytotoxicity of the complex-stabilizing DNA-topo II inhibitors such as VP-16 (etoposide) has been partially elucidated, the cytotoxicity of merbarone is poorly understood. Here, we report that merbarone induces programmed cell death or apoptosis in human leukemic CEM cells, characterized by internucleosomal DNA cleavage and nuclear condensation. Treatment of CEM cells with apoptosis-inducing concentrations of merbarone caused activation of c-Jun NH2-terminal kinase/stress-activated protein kinase, c-jun gene induction, activation of caspase-3/CPP32-like protease but not caspase-1, and the proteolytic cleavage of poly(ADP-ribose) polymerase. Treatment of CEM cells with a potent inhibitor of caspases, Z-Asp-2. 6-dichlorobenzoyloxymethyl-ketone, inhibited merbarone-induced caspase-3/CPP32-like activity and apoptosis in a dose-dependent manner. These results indicate that the catalytic inhibition of topo II by merbarone leads to apoptotic cell death through a caspase-3-like protease-dependent mechanism. These results further suggest that c-Jun and c-Jun NH2-terminal kinase/stress-activated protein kinase signaling may be involved in the cytotoxicity of merbarone. (+info)Interaction of 5-lipoxygenase with cellular proteins. (8/5831)
5-Lipoxygenase (5LO) plays a pivotal role in cellular leukotriene synthesis. To identify proteins interacting with human 5LO, we used a two-hybrid approach to screen a human lung cDNA library. From a total of 1.5 x 10(7) yeast transformants, nine independent clones representing three different proteins were isolated and found to specifically interact with 5LO. Four 1.7- to 1.8-kb clones represented a 16-kDa protein named coactosin-like protein for its significant homology with coactosin, a protein found to be associated with actin in Dictyostelium discoideum. Coactosin-like protein thus may provide a link between 5LO and the cytoskeleton. Two other yeast clones of 1.5 kb encoded transforming growth factor (TGF) type beta receptor-I-associated protein 1 partial cDNA. TGF type beta receptor-I-associated protein 1 recently has been reported to associate with the activated form of the TGF beta receptor I and may be involved in the TGF beta-induced up-regulation of 5LO expression and activity observed in HL-60 and Mono Mac 6 cells. Finally, three identical 2.1-kb clones contained the partial cDNA of a human protein with high homology to a hypothetical helicase K12H4. 8 from Caenorhabditis elegans and consequently was named DeltaK12H4. 8 homologue. Analysis of the predicted amino acid sequence revealed the presence of a RNase III motif and a double-stranded RNA binding domain, indicative of a protein of nuclear origin. The identification of these 5LO-interacting proteins provides additional approaches to studies of the cellular functions of 5LO. (+info)
A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity | Science
Search Articles | University of Toronto Libraries
TumorPortal
The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in...
The dve-1 gene and its possible relation to ageing in roundworms
Positioning edgetic residues in CED-9 structures. (a) P | Open-i
Implications of sequencing the nematode Caenorhabditis elegans genome for plant nematology
Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed...
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5<...
Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline | Genetics
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. | Genetics
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation - Infoscience
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation. - Oxford...
Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes | Science
DIGITAL.CSIC: Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline | Development
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
Altered expression of an L1-specific, O-linked cuticle surface glycoprotein in mutants of the nematode Caenorhabditis elegans. ...
On the nature of undead cells in the nematode Caenorhabditis elegans | Philosophical Transactions of the Royal Society B:...
The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal...
The role of insulin/IGF-like signaling in C. elegans longevity and aging. | Lewis-Sigler Institute
Serotonin-deficient Mutants and Male Mating Behavior in the Nematode Caenorhabditis Elegans - PubMed
An evidence-based approach to identify aging-related genes in Caenorhabditis elegans | BMC Bioinformatics | Full Text
IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans | EMBO Reports
Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology.
Caenorhabditis elegans MIG-13 protein
Summary Report | CureHunter
C. elegans** homologs of insect clock proteins: a tale of many stories - Institutional Repository University of Antwerp
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans - NASA/ADS
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans - CSHL Scientific Digital Repository
foxo;Pi3K92E
CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation |...
EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans | Nature Cell Biology
Genetic and molecular analysis of a Caenorhabditis elegans beta-tubulin that conveys benzimidazole sensitivity. | JCB
A semi-automated system based on level sets and invariant spatial interrelation shape features for Caenorhabditis elegans...
VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans | Development
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.
Fermented Brown Sugar Residue Prolongs the Caenorhabditis elegans Lifespan via DAF-16
A compendium of Caenorhabditis elegans RNA binding proteins predicts e by Alex M. Tamburino, Sean P. Ryder et al.
The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. -...
Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
Aging and resistance to oxidative damage in Caenorhabditis elegans | PNAS
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo | Journal of Cell Biology |...
Reliable CRISPR/Cas9 Genome Engineering in Caenorhabditis elegans Using a Single Efficient sgRNA and an Easily Recognizable...
The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval...
The C. elegans Male:Postembryonic Development of Nongonadal Structures
Developmental regulation of Caenorhabditis elegans DNA topoisomerase I expression<...
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to...
Origin, properties, and regulated expression of multiple mRNAs encoded by the protein kinase C1 gene of Caenorhabditis elegans<...
Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory...
Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and...
The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for...
QTL mapping for Caenorhabditis elegans survivorship in response to Escherichia coli and Stenotrophomonas maltophilia
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans | DR-NTU
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors<...
RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans | Journal...
Vulval development (Caenorhabditis elegans) - WikiPathways
Vulval development (Caenorhabditis elegans) - WikiPathways
Regulation of Tcl transposable elements in Caenorhabditis elegans.<...
Two Leucobacter strains exert complementary virulence on Caenorhabditis including death by worm-star formation. - Oxford...
Cytoplasmic flow and the establishment of polarity in C. elegans 1-cell embryos. - Semantic Scholar
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans : ubiquitin-conjugating enzymes,...
Family of FLP peptides in Caenorhabditis elegans and related nematodes by Chris Li and Kyuhyung Kim
Frontiers | Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans | Genetics
Navigational choice between reversal and curve during acidic pH avoidance behavior in Caenorhabditis elegans | BMC Neuroscience...
Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain | PNAS
lin-12 - Protein lin-12 precursor - Caenorhabditis elegans - lin-12 gene & protein
Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3 | The EMBO Journal
Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. - Semantic Scholar
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback - White Rose Research Online
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by...
OSA | Multiphoton laser scanning microscopy for four-dimensional analysis of Caenorhabditis elegans embryonic development.
MicroRNA targeting in mus musculus and Caenorhabditis elegans
Molecular and genetic characterization of GON-2, a TRPM cation channel required for gonadogenesis in Caenorhabditis elegans. ::...
Caenorhabditis elegans as an environmental monitor using DNA microarray analysis<...
PRIME PubMed | Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity
Hubers Killi-Data - Aphyosemion elegans, information snapshot (Cyprinodontiformes, Killifishes)
Immunoglobulin C2-set domain
Chothia C, Teichmann SA (2000). "Immunoglobulin superfamily proteins in Caenorhabditis elegans". J. Mol. Biol. 296 (5): 1367-83 ... "Protein-Protein Recognition: Juxtaposition of Domain and Interface Cores in Immunoglobulins and Other Sandwich-like Proteins". ... Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. ... CD2 displays structural and functional similarities with African swine fever virus (ASFV) LMW8-DR, a protein that is involved ...
Crustacean neurohormone family
Caenorhabditis elegans uncharacterised protein ZC168.2. These neurohormones are peptides of 70 to 80 amino acid residues which ... In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. The ...
FERM domain
Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E. Caenorhabditis elegans protein phosphatase ptp-1. Chishti ... Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is ... In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein ... Non-receptor tyrosine-protein kinase TYK2. Protein-tyrosine phosphatases PTPN3 and PTPN4, enzymes that appear to act at ...
Ced-3
... is one of the major protein components of the programmed cell death (PCD) pathway for Caenorhabditis elegans. There are ... "ced-3 Cell death protein 3 [ Caenorhabditis elegans ]". The National Center for Biotechnology Information. 2017-10-12. Shaham S ... elegans but for mammals as well. One of the main roles of the ced-3 protein in C. elegans is to help the development and growth ... "Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4". FEBS Letters. 406 (1-2): 189- ...
Vasa gene
"Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins". Genetics. 178 (4): 1973-87. doi:10.1534/ ... The protein product in humans has 724 amino acids, a molecular mass of 79 kDa and 8 conserved domains in all DEAD-box proteins ... Many other proteins in Drosophila are also localized to the poles. For example, Oskar protein was found to localize to pole ... Vasa is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. The vasa ...
Galactose binding lectin domain
The hypothetical B0457.1, F32A7.3A and F32A7.3B proteins from Caenorhabditis elegans. Ozeki Y, Matsui T, Suzuki M, Titani K ( ... In molecular biology, the galactose binding lectin domain is a protein domain. It is found in many proteins including the ... homologous to the SUEL protein has been identified in the following proteins: Plant beta-galactosidases EC 3.2.1.23 (lactases ... This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each ...
Epistasis and functional genomics
"Lin-26 Transcription factor lin-26 [Caenorhabditis elegans] - Gene - NCBI". "Lin-36 Protein lin-36 [Caenorhabditis elegans] - ... Data from protein-protein interaction studies can also provide a useful basis for selecting gene groups for E-MAP data. We ... and their data demonstrate that an E-MAP approach identifies protein-protein interactions with a specificity equal to that of ... 2007). "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map". ...
Andrew Dillin
His lab studies the loss of protein homeostasis in aging, particularly in Caenorhabditis elegans. His lab specifically looks at ... the manipulation of stress response pathways, such as the heat shock response and the unfolded protein response of the ...
Richard I. Morimoto
Prahlad, V; Morimoto, RI (2011). "Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins". ... "Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells". Genes & Development. 21 ... Prahlad, V.; Cornelius, T.; Morimoto, R.I. (2008). "Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by ... polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans ...
BED zinc finger
Caenorhabditis elegans Dpy-20 protein, a predicted cuticular gene transcriptional regulator; Drosophila BEAF (boundary element- ... In molecular biology the BED-type zinc finger domain is a protein domain which was named after the Drosophila proteins BEAF and ... Some proteins known to contain a BED domain include animal, plant and fungi AC1 and Hobo-like transposases; ... and ethylene-regulated DNA binding proteins that contain two BED fingers. Most genes in this family are believed to have ...
SbRNA
"Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins". BMC ... Li T; He H; Wang Y; Zheng H; Skogerbø G; Chen R (2008). "In vivo analysis of Caenorhabditis elegans noncoding RNA promoter ... sbRNA (stem-bulge RNA) is a family of non-coding RNA first discovered in Caenorhabditis elegans. It was identified during a ... March 2005). "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans". Nature. 434 (7032): 462-9. doi: ...
Cell nucleus
"Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans". Primary. BMC ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ... Both structures serve to mediate binding to nuclear transport proteins. Most proteins, ribosomal subunits, and some RNAs are ... Speckles are dynamic structures, and both their protein and RNA-protein components can cycle continuously between speckles and ...
IMD domain
Caenorhabditis elegans M04F3.5 protein. The vertebrate IRSp53/MIM family is divided into two major groups: the IRSp53 subfamily ... Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like ... Vertebrate ABBA-1 (MTSS1L), a MIM-related protein. Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 ( ... a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/ ...
B3GAT3
Herman T, Horvitz HR (1999). "Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor ... This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in ...
UNC93B1
This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the ... Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene. ... This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum ... Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to ...
RBFOX1
"Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals". Molecular and Cellular ... or hexaribonucleotide-binding protein 1 (HRNBP1) or RNA binding protein, fox-1 homolog (Rbfox1), is a protein that in humans is ... Rbfox1 has an RNA recognition motif that is highly conserved among RNA-binding proteins. Rbfox1, and the related protein Rbfox2 ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ...
NeuN
... a protein which is a homologue to the protein product of a sex-determining gene in Caenorhabditis elegans, is a neuronal ... Underwood JG, Boutz PL, Dougherty JD, Stoilov P, Black DL (2005). "Homologues of the Caenorhabditis elegans Fox-1 protein are ... Fox-3 is one of a family of mammalian homologues of the Fox-1 protein, originally discovered in the nematode worm C. elegans as ... a protein originally identified from genetic studies of the nematode worm C. elegans. Western blotting shows that mAb A60 binds ...
Iain Cheeseman
Cheeseman is noted for discovering multiple new kinetochore proteins within yeast, the Caenorhabditis elegans worm and human ... He recently demonstrated a critical and direct role for a protein complex called Ndc80 (coded for by the gene NDC80) in ... Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR 3rd, Oegema K, Desai A (September 2004). "A conserved protein network ... Certain cancer drugs target the connection between chromosomes and spindle microtubules, and some of the major proteins in the ...
Gluconeogenesis
"Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle". ... Transport of PEP across the mitochondrial membrane is accomplished by dedicated transport proteins; however no such proteins ... it triggers phosphorylation of enzymes and regulatory proteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in ... In the liver, the FOX protein FoxO normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox0 upon feeding ...
ARL13B
2010). "Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans". J. ... ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein ... This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in the ARL13B ... The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. ...
UNC93A
Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that ... Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene. Unc93A is a major facilitator ... and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The ... Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see: ...
Daf-1
... of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". ... the SMAD proteins in C. elegans. Georgi LL, Albert PS, Riddle DL (May 1990). "daf-1, a C. elegans gene controlling dauer larva ... Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta ... DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans. ...
Ashish Arora
... like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegans". Biomolecular NMR Assignments. 9 (2): 261-265. doi: ... He is known for his studies on Protein NMR Spectroscopy and the pathogenesis of diseases such as tuberculosis and visceral ... Proteins and Proteomics. 1864 (10): 1304-1314. doi:10.1016/j.bbapap.2016.06.013. PMID 27378575. Shukla, Vaibhav Kumar; Kabra, ...
Daf-7
... of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". ... The DAF-7 gene encodes for the ortholog of GDF11, a ligand of TGF-beta signaling pathway, in the worm Caenorhabditis elegans. ... this receptor protein serine/threonine kinase will phosphorylation activate the Smad Protein Daf-8/14. Morita K, Shimizu M, ... Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings ...
Daf-4
... of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". ... The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans, with the ... Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma ... and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and ...
EMI domain
"EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein". Biochem. Biophys. ... Caenorhabditis elegans ced-1, a transmembrane receptor that mediates cell corpse engulfment. Doliana R, Bot S, Bonaldo P, ... It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was ... Vertebrate Emu proteins, which could interact with several different extracellular matrix components and serve to connect and ...
Ap180
July 1999). "UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles ... A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its ... AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. It is capable of ... In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the ...
Uncoordinated-119 (Unc-119)
... a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses". The Journal ... The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans ... prenyl binding protein) and rhoGDI. It has been given many different names: Retinal Protein 4, HRG4, POC7 Centriolar Protein ... The UNC-119 protein plays key roles in the movement and feeding in the C. elegans, because it is essential in the development ...
UPF3A
... a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. 9 (1 ... This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It ... Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene. This gene encodes a protein that ... Caenorhabditis elegans SMG-4)". Mol Cell Biol. 21 (1): 209-23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795. PMID 11113196. ...
Synaptic vesicle
"The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein". Journal of ... Trafficking proteins are more complex. They include intrinsic membrane proteins, peripherally bound proteins, and proteins such ... In C. elegans the major motor for synaptic vesicles is UNC-104. There is also evidence that other proteins such as UNC-16/ ... however none of the identified protein interactions between the vesicle proteins and release site proteins can account for the ...
人類基因組 - 维基百科,自由的百科全
Caenorhabditis elegans. 秀麗隱杆線蟲 97,000,000 18,250 Arabidopsis thaliana. 阿拉伯芥(擬南芥) 125,000,000 25,500 ... non-protein-coding genes, and chromosomal structural elements) under selection for biological function.. " Mouse Genome ... This proportion is much higher than can be explained by protein-coding sequences alone, implying that the genome contains many ...
Bioinformática, a enciclopedia libre
... as 97 Mbp do verme Caenorhabditis elegans),[66] para rematar a década co primeiro cromosoma humano (o 22), que foi ... "A structural perspective on protein-protein interactions" (PDF). Current Opinion in Structural Biology 14. Páxs. 313-324. ... C. elegans Sequencing Consortium (1998). "Genome sequence of the nematode C. elegans: a platform for investigating biology". ... "Protein Engineering 7 (7). ISSN 1741-0134, Páxs. 841-848.. *↑ 70,0 70,1 Thompson, J. D.; et al. (1994). "CLUSTAL W: improving ...
RAD51
The recombinase paralog rfs-1 is found in the round worm Caenorhabditis elegans, where it is not essential for homologous ... protein C-terminus binding. • protein binding. • four-way junction DNA binding. • identical protein binding. • ... This protein can interact with the ssDNA-binding protein RPA, BRCA2, PALB2[10] and RAD52. ... Protein domains in homologous recombination-related proteins are conserved across the three main groups of life: archaea, ...
Ensembl - Wicipedia
Abwydod: Caenorhabditis elegans. *Burum: Saccharomyces cerevisiae (burum pobi). Cyfeiriadau[golygu , golygu cod y dudalen]. *↑ ... Opsiwn arall yw anodiad awtomatig - defnyddio pŵer cyfrifiadurol i gymharu dilyniannau protein a DNA. ...
MSH4, a enciclopedia libre
O xene him-14 do verme Caenorhabditis elegans codifica un ortólogo de MSH4.[7] A formación de sobrecruzamentos durante a meiose ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173-8. PMID 16189514. doi: ... Winand NJ, Panzer JA, Kolodner RD (1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the ... Winand NJ, Panzer JA, Kolodner RD (Oct 1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of ...
Amyotrophic lateral sclerosis
Caenorhabditis elegans (a roundworm), Drosophila melanogaster (the common fruit fly), Danio rerio (the zebrafish), Mus musculus ... There are a number of ALS genes that encode for RNA-binding proteins. The first to be discovered was TDP-43 protein,[35] a ... Mutant SOD1 protein forms intracellular aggregations that inhibit protein degradation. Cytoplasmic aggregations of wild-type ( ... Once these mutant RNA-binding proteins are misfolded and aggregated, they may be able to misfold normal protein both within and ...
Eukaryoty - Wikipédia
Červ Caenorhabditis elegans je príkladom dobre známeho mnohobunkového živočícha; každá z jeho 1090 somatických buniek má svoj ... The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces ...
RNA - Simple English Wikipedia, the free encyclopedia
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862. ... Protein synthesis RNAs[change , change source]. Messenger RNA[change , change source]. The structure of a mature eukaryotic ... An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864. ... Genes code for proteins in bits called exons. The bits can be joined together in different ways to make different mRNAs. Thus, ...
Lasker Award
... his daring introduction of the roundworm Caenorhabditis elegans as a system for tracing the birth and death of every cell in a ... For discoveries concerning the nutrient-activated TOR proteins and their central role in the metabolic control of cell growth.[ ... For their invention of Herceptin, the first monoclonal antibody that blocks a cancer-causing protein, and for its development ... For the discovery and recognition of the broad significance of the ubiquitin system of regulated protein degradation, a ...
Multicellular organism
... which helps form the skin of Caenorhabditis elegans, part of a whole family of FF proteins. Felix Rey, of the Pasteur Institute ... In this image, a wild-type Caenorhabditis elegans is stained to highlight the nuclei of its cells. ... About 800 million years ago,[37] a minor genetic change in a single molecule called guanylate kinase protein-interaction domain ... in Paris has constructed the 3D structure of the EFF1 protein[39] and shown it does the work of linking one cell to another, in ...
Single cell sequencing
... including the worm Caenorhabditis elegans,[75] and the regenerative planarian Schmidtea mediterranea[76][77] and axolotl ... October 2017). "Multiplexed quantification of proteins and transcripts in single cells". Nature Biotechnology. 35 (10): 936-939 ... In 2017, two approaches were introduced to simultaneously measure single-cell mRNA and protein expression through ...
Synapse
... was identified in Caenorhabditis elegans that encodes myo-inositol monophosphatase (IMPase), an enzyme that produces inositol ... This led to the conclusion that IMPase is required for the correct localization of synaptic protein components.[13][14] The egl ... "Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by myo-Inositol Monophosphatase in Caenorhabditis elegans ... "Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans ...
Thaumatin
This thaumatin domain has been found in species as diverse as rice and Caenorhabditis elegans. Thaumatins are pathogenesis- ... Curculin, a sweet protein from Malaysia with taste-modifying activity. *Miraculin, a protein from West Africa with taste- ... The thaumatin protein is considered a prototype for a pathogen-response protein domain. ... similarity between this PR protein and other PR proteins to the maize alpha-amylase/trypsin inhibitor has suggested PR proteins ...
DNA sequencing
Caenorhabditis elegans, and Saccharomyces cerevisiae at a cost of US$0.75 per base. Meanwhile, sequencing of human cDNA ... Protein nanopore sequencing utilizes membrane protein complexes such as α-hemolysin, MspA (Mycobacterium smegmatis Porin A) or ... a small protein secreted by the pancreas. This provided the first conclusive evidence that proteins were chemical entities with ... Sanger is one of the few scientists who was awarded two Nobel prizes, one for the sequencing of proteins, and the other for the ...
EIF3A
Caenorhabditis elegans, and Saccharomyces cerevisiae". J. Biol. Chem. 272 (11): 7106-13. doi:10.1074/jbc.272.11.7106. PMID ... Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene.[5][6][7] ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134 ... protein binding. • structural molecule activity. • translation initiation factor activity. • receptor tyrosine kinase binding. ...
Evolution of nervous systems
The nervous system of one very small worm, the roundworm Caenorhabditis elegans, has been mapped out down to the synaptic level ... Recent studies have shown that sponge cells express a group of proteins that cluster together to form a structure resembling a ... In C. elegans, males have exactly 383 neurons, while hermaphrodites have exactly 302 neurons.[14] ... In choanoflagellates and mesomycetozoea, these proteins are upregulated during colonial phases, suggesting the importance of ...
ಹಂಟಿಂಗ್ಟನ್ನ ಕಾಯಿಲೆ - ವಿಕಿಪೀಡಿಯ
"Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans". PLoS ONE. 2 (6): e504. ... "Huntingtin Protein and Protein Aggregation , HOPES - A guide to the science of Huntington's disease".. ... "A protein interaction network links GIT1, an enhancer of Huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): ... "Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity". Science. 324 (5932): 1327-30. doi:10.1126/science ...
Antioxidant
"Aging and resistance to oxidative damage in Caenorhabditis elegans". Proceedings of the National Academy of Sciences of the ... The thioredoxin system contains the 12-kDa protein thioredoxin and its companion thioredoxin reductase.[149] Proteins related ... while damage to proteins causes enzyme inhibition, denaturation and protein degradation.[60] ... to support the role of oxidative stress in aging in model organisms such as Drosophila melanogaster and Caenorhabditis elegans, ...
Craig Mello
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, in Nature, via University of ... before it can produce a protein - effectively shutting specific genes down. ... "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans". Nature. 391 (6669): 806-811. ...
Programmed cell death
doi:10.1016/0012-1606(80)90352-8. Sulston2, JE (1983). "The embryonic cell lineage of the nematode Caenorhabditis elegans". ... and the scaffold protein FIP200. Class III PI3K complex, containing hVps34, Beclin-1, p150 and Atg14-like protein or ... doi:10.1016/s0306-4522(01)00050-1. Sulston, JE (1980). "The Caenorhabditis elegans male: postembryonic development of ... It has also been shown that in mice null for the proapoptotic factor Bax (Bcl-2-associated X protein) a larger percentage of ...
Genetics
... the nematode Caenorhabditis elegans, the common fruit fly (Drosophila melanogaster), and the common house mouse (Mus musculus ... 2002), I.3. Proteins: The Shape and Structure of Proteins *^ Alberts et al. (2002), I.3. Proteins: Protein Function Archived 25 ... like the fibers formed by the protein collagen. Proteins can bind to other proteins and simple molecules, sometimes acting as ... A single nucleotide difference within DNA can cause a change in the amino acid sequence of a protein. Because protein ...
RNA interference
Exogenous dsRNA is detected and bound by an effector protein, known as RDE-4 in C. elegans and R2D2 in Drosophila, that ... Kamath RS, Ahringer J (August 2003). "Genome-wide RNAi screening in Caenorhabditis elegans". Methods. 30 (4): 313-21. doi: ... Exogenous dsRNA is detected and bound by an effector protein, known as RDE-4 in C. elegans and R2D2 in Drosophila, that ... Fortunato A, Fraser AG (2005). "Uncover genetic interactions in Caenorhabditis elegans by RNA interference". Bioscience Reports ...
Eukaryoty - Wikipédia
Červ Caenorhabditis elegans je príkladom dobre známeho mnohobunkového živočícha; každá z jeho 1090 somatických buniek má svoj ... Bacterial proteins pinpoint a single eukaryotic root. Proceedings of the National Academy of Sciences of the United States of ... The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces ...
John Graham White
Durbin, Richard Michael (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans ( ... Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825-836. ... Caenorhabditis elegans. Wall chart". Science. 270 (5235): 415-430. doi:10.1126/science.270.5235.410. PMID 7569996.. ... White, John (1975). Computer aided reconstruction of the nervous system of Caenorhabditis elegans (PhD thesis). University of ...
MYO6
It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans). ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... protein complex. • apical part of cell. • clathrin-coated vesicle membrane. • ruffle. • cytosol. • extracellular exosome. • ... protein binding. • minus-end directed microfilament motor activity. • ADP binding. • actin binding. • nucleotide binding. • ...
Interferencia de ARN, a enciclopedia libre
Kamath R, Ahringer J (2003). "Genome-wide RNAi screening in Caenorhabditis elegans". Methods 30 (4): 313-21. PMID 12828945. doi ... Antisense nucleic acids and proteins: fundamentals and applications. pp. 4, 136. ISBN 0824785169.. ... Fortunato A, Fraser A (2005). "Uncover genetic interactions in Caenorhabditis elegans by RNA interference". Biosci Rep 25 (5-6 ... chamada RDE-4 no verme Caenorhabditis elegans e R2D2 na mosca Drosophila, que estimula a actividade de Dicer.[12] Esta proteína ...
PARD6A - ويكيبيديا
Johansson A، Driessens M، Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is ... Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein ... GTP-dependent protein binding. • GO:0001948 ربط بروتيني. • Rho GTPase binding. • protein kinase C binding. ... Joberty G، Petersen C، Gao L، Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to ...
Potato
In this respect, potato tuber tissue is similar to Drosophila melanogaster, Caenorhabditis elegans and Escherichia coli: they ... the modifications do not cause new proteins to be made, but rather prevent proteins from being made via RNA interference.[50][ ... Protein (g) 9.4 7.1 12.6 2.0 1.4 13.0 1.6 1.5 11.3 1.3 50 ... protein, and contains negligible fat (see table). In an amount ... especially the addition of various high-fat or high-protein toppings).[62] In particular, consuming reheated or cooled potatoes ...
Salk Institute for Biological Studies
Sydney Brenner, Nobel laureate (for work with Caenorhabditis elegans). *Roger Guillemin, Nobel laureate (for elucidating the ... Tony Hunter, discoverer of tyrosine phosphorylation of proteins.. *Juan Carlos Izpisua Belmonte, prominent developmental ...
RNA-interferens, den frie encyklopædi
"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans". Nature. 391 (6669): 806-11. PMID ... der ikke længere kan translateres til protein. En type af RNA transkriberet fra genomet, miRNA, arbejder på samme måde.[2] ...
Apical junction molecule [Caenorhabditis elegans] - Protein - NCBI
Apical junction molecule [Caenorhabditis elegans] Apical junction molecule [Caenorhabditis elegans]. gi,1061385445,ref,NP_ ... Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. [Dev Biol. 2004 ... Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. [Nat Cell Biol. 2001] ... Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans.. Segbert C, ...
Myoblast growth factor receptor egl-15 [Caenorhabditis elegans] - Protein - NCBI
Myoblast growth factor receptor egl-15 [Caenorhabditis elegans] Myoblast growth factor receptor egl-15 [Caenorhabditis elegans] ... N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo. [J Biol Chem. ... N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo.. Polanska UM, ... Myoblast growth factor receptor egl-15 [Caenorhabditis elegans]. NCBI Reference Sequence: NP_001300354.1 ...
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans | PNAS
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Sanjeev H. Satyal, Enrico Schmidt, ... Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Sanjeev H. Satyal, Enrico Schmidt, ... Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans Message Subject (Your Name) has sent you a ... Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Sanjeev H. Satyal, Enrico Schmidt, ...
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins | PNAS
2000) Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97:5750-5755 ... Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins Message Subject (Your Name) has sent ... Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases ... Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Veena Prahlad and Richard I. ...
C46A5.1 - Uncharacterized protein - Caenorhabditis elegans - C46A5.1 gene & protein
Caenorhabditis briggsae. Caenorhabditis tropicalis. Caenorhabditis elegans. Caenorhabditis remanei (Caenorhabditis vulgaris). ... tr,Q18652,Q18652_CAEEL Uncharacterized protein OS=Caenorhabditis elegans GN=C46A5.1 PE=4 SV=1 ... Protein predictedi ,p>This indicates the type of evidence that supports the existence of the protein. Note that the protein ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q18652. A8XRK5. A0A1I7SXY4. E3M536. ...
C01G5.5 - Uncharacterized protein - Caenorhabditis elegans - C01G5.5 gene & protein
Caenorhabditis elegans. Caenorhabditis tropicalis. Caenorhabditis latens. Caenorhabditis remanei (Caenorhabditis vulgaris). ... Caenorhabditis brenneri (Nematode worm). Caenorhabditis japonica. 287. UniRef50_Q17568. Cluster: Uncharacterized protein. 8. ... tr,Q17568,Q17568_CAEEL Uncharacterized protein OS=Caenorhabditis elegans GN=C01G5.5 PE=1 SV=1 ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ...
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans | Science
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans. By Anders Olsen, Maithili C. ... Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans. By Anders Olsen, Maithili C. ... Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans Message Subject. (Your Name) has ...
Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant...
Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant ... P. B. L. Pun, J. Gruber, S. Y. Tang et al., "Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?" ... P. Martorell, E. Bataller, S. Llopis et al., "A cocoa peptide protects Caenorhabditis elegans from oxidative stress and β- ... Q. Wang, F. Yang, W. Guo et al., "Caenorhabditis elegans in Chinese medicinal studies: making the case for aging and ...
A Ubiquitin E2 Variant Protein Acts in Axon Termination and Synaptogenesis in Caenorhabditis elegans | Genetics
Li, H., G. Kulkarni and W. G. Wadsworth, 2008 RPM-1, a Caenorhabditis elegans protein that functions in presynaptic ... A Ubiquitin E2 Variant Protein Acts in Axon Termination and Synaptogenesis in Caenorhabditis elegans. Gloriana Trujillo, ... A Ubiquitin E2 Variant Protein Acts in Axon Termination and Synaptogenesis in Caenorhabditis elegans. Gloriana Trujillo, ... A Ubiquitin E2 Variant Protein Acts in Axon Termination and Synaptogenesis in Caenorhabditis elegans. Gloriana Trujillo, ...
spe-12 Encodes a Sperm Cell Surface Protein That Promotes Spermiogenesis in Caenorhabditis elegans | Genetics
1989 Posttranslational insertion of a membrane protein on Caenorhabditis elegans sperm occurs without de novo protein synthesis ... 1983 Identification of a large multigene family encoding the major sperm protein of Caenorhabditis elegans. J. Mol. Biol. 171: ... Mitogen-activated protein (MAP) kinase signaling pathways in the nematode Caenorhabditis elegans, for example, are known to ... spe-12 Encodes a Sperm Cell Surface Protein That Promotes Spermiogenesis in Caenorhabditis elegans. Jeremy Nance, Alicia N. ...
SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans
... Author(s). Galvin, Brendan D.; Denning, ... DownloadGalvin-2011-Feb-SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans.pdf (269.5Kb) ... "SPK-1, an SR Protein Kinase, Inhibits Programmed Cell Death in Caenorhabditis Elegans." Proceedings of the National Academy of ... We conclude that programmed cell death in C. elegans is regulated by an alternative splicing event controlled by the SR protein ...
Mitochondrial Unfolded-Protein Response (Caenorhabditis elegans) - WikiPathways
Protein. C18E9.6 (WormBase) UBL-5. Protein. F46F11.4 (WormBase) Unfolded Proteins. Protein. dnj-10. GeneProduct. F22B7.5 ( ... Mitochondrial Unfolded-Protein Response (Caenorhabditis elegans). From WikiPathways. Revision as of 20:23, 24 January 2014 by ... Protein. ZC376.7 (WormBase) CLPP-1. Protein. ZK970.2 (WormBase) ClpX-like Protease/ (D2030.2). Protein. D2030.2 (Ensembl) ClpX- ... Unfolded Proteins. Protein Fragments. GCN-2. ATFS-1. eIF2-alpha. (Y37E3.10). ClpX-like. Protease/. (K07A3.3). HSP-60. SPG-7. 9 ...
Mitochondrial Unfolded-Protein Response (Caenorhabditis elegans) - WikiPathways
Protein. C18E9.6 (WormBase) UBL-5. Protein. F46F11.4 (WormBase) Unfolded Proteins. Protein. dnj-10. GeneProduct. F22B7.5 ( ... Mitochondrial Unfolded-Protein Response (Caenorhabditis elegans). From WikiPathways. Revision as of 22:21, 29 January 2014 by ... Protein. ZC376.7 (WormBase) CLPP-1. Protein. ZK970.2 (WormBase) ClpX-like Protease/ (D2030.2). Protein. D2030.2 (Ensembl) ClpX- ... Protein Fragments. ATFS-1 Fragments. CLPP-1. Unfolded Proteins. GCN-2. GSP-1. ClpX-like. Protease/. (D2030.2). HSP-6. Ethidium ...
Structure Cluster
- 1PEV: Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans 3D...
Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin ... Description: Actin interacting protein 1 protein , Length: 611 No structure alignment results are available for 1PEV.A ... Pre-calculated protein structure alignments at the RCSB PDB website. Bioinformatics 26: 2983-2985 ...
Analysis of protein-protein interaction by in vivo quantitative proteomics in Caenorhabditis elegans
In C. elegans, early embryogenesis provides an attractive model system for mapping in vivo protein interactions. In order to ... Die dynamische Regulation von Protein-Protein Interaktionen (PPIs) ist wichtig für den Ablauf von biologischen Prozessen. Die ... Molecular functions of the ubiquitin domain protein Herp in Synoviolin mediated endoplasmic reticulum associated protein ... In C. elegans bietet die frühe Embryogenese ein attraktives Modellsystem, um Wechselwirkungen von Proteinen in vivo zu ...
Caenorhabditis elegans MIG-13 protein
Summary Report | CureHunter
... isolated from Caenorhabditis elegans; amino acid sequence in first source; GenBAnk AF150958 ... Caenorhabditis elegans MIG-13 protein: required for positioning of Q neuroblasts and their descendents along the ... Helminth Proteins: 1*Caenorhabditis elegans Proteins: 4*Caenorhabditis elegans MIG-13 protein ... Caenorhabditis elegans MIG-13 protein. Subscribe to New Research on Caenorhabditis elegans MIG-13 protein ...
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, ... Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling Nat Genet. 2001 Jun; ... The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, ... Lifespan in C. elegans can be extended by perturbing sensory neurons or germ cells. In both cases, lifespan extension requires ...
Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans | Science
Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans ... Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans ... Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans ... Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans ...
RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans | Journal...
The Caenorhabditis elegans Regulator of Presynaptic Morphology (RPM)-1 is a member of a conserved family of proteins called Pam ... RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans. Brock ... 2008) Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Dev ... RAE-1, a Novel PHR Binding Protein, Is Required for Axon Termination and Synapse Formation in Caenorhabditis elegans ...
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by...
... of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by the Homeodomain Protein ... 1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond [Biol] 314:1-340. ... 1993) A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc Natl Acad Sci USA 90:2227-2231. ... In Caenorhabditis elegans, 10 putative ionotropic glutamate receptor subunits have been identified, a surprising number for an ...
Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis
Here we report that the Caenorhabditis elegans homolog … ... Arginine methylation of histone and non-histone proteins is ... Nevertheless, whether such protein modification plays a regulatory role during apoptosis remains largely unknown. ... Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis PLoS Genet. ... Caenorhabditis elegans / radiation effects * Caenorhabditis elegans Proteins / genetics * Caenorhabditis elegans Proteins / ...
A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans | Development
A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans ... A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans ... A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans ... A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans ...
Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans | SpringerLink
Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. ... Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans. *J. M. Wentz ORCID ... Hua QX, Nakagawa SH, Wilken J, Ramos RR, Jia W, Bass J, Weiss MA (2003) A divergent INS protein in Caenorhabditis elegans ... Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and ...
Regulatory elements of Caenorhabditis elegans ribosomal protein genes | BMC Genomics | Full Text
... elegans RPGs, providing a new insight regarding the regulation of these genes in C. elegans. In this study, we performed an in- ... depth examination of C. elegans RPG regulation and found nine highly conserved motifs in the upstream regions of C. elegans ... Even though their protein sequences are strongly conserved, their mechanism of regulation is not conserved across yeast, ... Our results indicate that C. elegans RPGs are regulated by a complex novel series of regulatory elements that is evolutionarily ...
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation | Development
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation ... DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation ... DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation ... DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation ...
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism | Protocol
... we monitored changes in protein folding by following protein... ... To study the relationship between protein homeostasis, stress ... Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism. Ido Karady1, Anna ... Prahlad, V., Morimoto, R. I. Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc. ... we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein ...
DIGITAL.CSIC: Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans
Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans. ... In early Caenorhabditis elegans embryos, VRK-1 is required for proper nuclear envelope formation. In this work, we present the ... Caenorhabditis elegans. Cell invasion. Cell polarity. Cell signaling. FGF. Uterus. Vaccinia-related kinase. vrk-1. Vulva. ... Expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting ...
mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of...
Normal locomotion of the nematode Caenorhabditis elegans requires transmission of contractile force through a series of ... 0/Caenorhabditis elegans Proteins; 0/Cell Adhesion Molecules; 0/Helminth Proteins; 0/Lipoprotein(a); 0/MUA-3 protein, C elegans ... Caenorhabditis elegans / genetics, metabolism*. Caenorhabditis elegans Proteins*. Cell Adhesion / physiology. Cell Adhesion ... MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans. J. Cell Biol. 154: ...
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation - Infoscience
In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have ... The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation Rogala, Kacper B ; ... In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have ... Home , The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation ...
SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast |...
SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast. ... SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast ... SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast ... SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast ...
NematodeNeuronsAbstractHomologRegulationKinaseGeneticsEncodes a novelDevelopmentalMolecularDrosophilaActivity in Caenorhabditis elegansReceptorPathwaysGeneticCytoplasmicMRNARNAiHomologueMutationRegulatesInteractionsInteractionMutantsNematodesSaccharomycesTransmembrane proteinMembrane ProteinsExtracellularTranscriptionSubunitFamily of proteinsLifespan2002Fluorescent proteinsCellsFunctionalChromatinOrganismActinYeastHighly conservedEmbryosVivoEmbryonicEndogenousResistanceMyosin thick filamentsMutationsPathwayEscherichiaGenomeCellularPhenotypeMammalsHomeostasisLarvaeOxidative stressEpithelialIsoformsFragmentsKinases
Nematode24
- The nematode C. elegans naturally develops as either an XO male or XX hermaphrodite. (biologists.org)
- A recent investigation of genomic sequences conserved across both nematode species and associated with different gene groups indicated the existence of several elements in the upstream regions of C. elegans RPGs, providing a new insight regarding the regulation of these genes in C. elegans . (biomedcentral.com)
- Normal locomotion of the nematode Caenorhabditis elegans requires transmission of contractile force through a series of mechanical linkages from the myofibrillar lattice of the body wall muscles, across an intervening extracellular matrix and epithelium (the hypodermis) to the cuticle. (biomedsearch.com)
- Thus, MUA-3 appears to be a protein that links the IF cytoskeleton of nematode epithelia to the cuticle at sites of mechanical stress. (biomedsearch.com)
- By searching potential Fe65 -like genes in the nematode Caenorhabditis elegans , we identified a single gene, feh-1 ( Fe 65 h omolog-1), encoding a protein with a high sequence similarity to mammalian Fe65s. (biologists.org)
- The non-redundant system of the nematode will prove useful for studying the basic biology of the Fe65-APP interaction and the molecular events regulated by this evolutionarily conserved system of interacting proteins. (biologists.org)
- Interestingly, the nematode Caenorhabditis elegans, which possesses ILP and ILS, also prolongs its lifespan through decreased metabolism during periods of starvation or other chronic stresses (heat, crowding, etc. (cornell.edu)
- BACKGROUND: The genome of the nematode Caenorhabditis elegans contains more than 30 putative globin genes that all are transcribed. (inserm.fr)
- Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). (umassmed.edu)
- Here, we provide a protocol for a Venus-based BiFC assay to visualize protein interactions in the living nematode, Caenorhabditis elegans. (researchwithrowan.com)
- The nematode Caenorhabditis elegans serves as a genetic model to study cell invasion during normal development. (biomedsearch.com)
- We used killing of the nematode Caenorhabditis elegans by C. neoformans as an assay to screen a library of random C. neoformans insertion mutants. (duke.edu)
- UBC-2, an essential E2 in the nematode C. elegans, is a functional homolog of Saccharomyces cerevisiae UBC4, a member of a branch of ubiquitin-conjugating enzymes required for the degradation of short-lived and abnormal proteins. (ubc.ca)
- Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. (metaorganism-research.com)
- The nematode Caenorhabditis elegans expresses substantial amounts of several forms (Mr values = 39,000-41,000) of the catalytic subunit (C) of cAMP-dependent protein kinase. (elsevier.com)
- We show that RNT-1, the Caenorhabditis elegans RUNX homolog, is constantly produced and degraded by the ubiquitination-proteasome pathway in the intestine of the nematode. (elsevier.com)
- The reaction of an abundant 106-kDa polypeptide with a specific monoclonal antibody has been localized in intestinal and muscle cells of the nematode Caenorhabditis elegans. (utmb.edu)
- The nematode C. elegans provides many advantages for a molecular genetic approach to signal transduction. (yu.edu)
- Evidence is presented for the presence of this protein in the nematode. (yu.edu)
- Muscles of the nematode Caenorhabditis elegans have been studied extensively, and show significant similarity to vertebrate muscles. (biologists.org)
- The nematode Caenorhabditis elegans possesses a mevalonate pathway that lacks the branch leading to cholesterol synthesis, and thus represents an ideal organism to specifically study the noncholesterol roles of the pathway. (gu.se)
- Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments. (news-medical.net)
- In the nematode Caenorhabditis elegans , a large number of neuropeptide genes that are expressed throughout the nervous system have been identified. (frontiersin.org)
- The first completed neural connectome was that of the nematode Caenorhabditis elegans ( 1 ). (frontiersin.org)
Neurons16
- Huntington's disease, the most frequent of these autosomal dominant diseases, is characterized by insoluble granular and fibrous deposits of huntingtin protein in neurons ( 6 , 7 ). (pnas.org)
- Previous findings that the heat shock response in Caenorhabditis elegans is regulated by thermosensory neurons led us to consider whether neuronal activity could also be responsible for the inadequate response of an organism to chronic protein misfolding. (pnas.org)
- Whereas polyglutamine expansion-expressing animals with WT thermosensory neurons readily express protein aggregates, leading to cellular dysfunction without concomitant up-regulation of molecular chaperones, modulation of the nervous system results in chaperone up-regulation that suppresses aggregation and toxicity. (pnas.org)
- Cell-nonautonomous control of chaperone expression by the thermosensory neurons allows C. elegans to respond differently to acute stress such as heat shock, and chronic stress caused by the expression of misfolded proteins, suggesting that neuronal signaling determines the course of cellular proteotoxicity. (pnas.org)
- Previous studies in the metazoan Caenorhabditis elegans have shown that the HSR is regulated by the AFD thermosensory neurons and AIY interneurons ( 29 ). (pnas.org)
- Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress," Molecules , vol. 19, no. 6, pp. 7757-7769, 2014. (hindawi.com)
- Lifespan in C. elegans can be extended by perturbing sensory neurons or germ cells. (nih.gov)
- In Caenorhabditis elegans , 10 putative ionotropic glutamate receptor subunits have been identified, a surprising number for an organism with only 302 neurons. (jneurosci.org)
- We also show that expression of these subunits in this circuit is differentially regulated by the homeodomain protein UNC-42 and that UNC-42 is also required for axonal pathfinding of neurons in the circuit. (jneurosci.org)
- To address questions of receptor complexity, composition, and organization at the level of individual neurons, we have examined the expression and regulation of ionotropic glutamate receptor subunits in the nervous system of C. elegans . (jneurosci.org)
- The sup-1 gene encodes a single-pass transmembrane protein that is expressed in a subset of neurons and in body muscles. (ox.ac.uk)
- Singhal, A. & Shaham, S. Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons. (nature.com)
- MAPH-1.1 co-purified specifically with DLG-1 purified from neurons, and shared limited homology with the microtubule-associated protein MAP1A, a known neuronal interaction partner of mammalian DLG4/PSD95. (uu.nl)
- CLH-1GFP was expressed in some unidentified head neurons and posterior intestinal cells of C. elegans. (bvsalud.org)
- New research at the Okinawa Institute of Science and Technology Graduate Universit used microscopy techniques to piece together the brain of the millimeter-long Caenorhabditis elegans, revealing that their neurons fire action potentials - a spike in voltage due to neurons sending sensory information in the cell membrane. (news-medical.net)
- Most neurons in C. elegans express at least one neuropeptide gene and in the majority of neurons, neuropeptides are co-localized with classical small molecule transmitters, such as acetylcholine, GABA, serotonin (5-HT), and dopamine ( 3 , 4 ). (frontiersin.org)
Abstract3
- abstract = "In Caenorhabditis elegans, as in other animals, Notch-type signaling mediates numerous inductive events during development. (syr.edu)
- Department of Biochemistry and Molecular Biology The University of British Columbia 2146 Health Sciences Mall Vancouver, B.C. V6T 1Z3 Date: May 15,2002 ABSTRACT A major route for protein degradation occurs via the ubiquitin-proteasome pathway. (ubc.ca)
- abstract = "Calcineurin (Cn) is a calcium/calmodulin-dependent serine/threonine protein phosphatase that has diverse functions in different cell types and organisms. (elsevier.com)
Homolog6
- The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathway. (nih.gov)
- Here we report that the Caenorhabditis elegans homolog of mammalian type II arginine methyltransferase PRMT5 negatively regulates DNA damage-induced apoptosis. (nih.gov)
- DPY-30 is required for the sex-specific association of DPY-27 (a chromosome condensation protein homolog) with the hermaphrodite X chromosomes. (biologists.org)
- These data are consistent with zig-4 attenuating ILP-dependent ILS and with zig-4 possibly encoding an Imp-L2 homolog in C. elegans. (cornell.edu)
- Here we used genome-wide expression profiling to assess novel functions of the Caenorhabditis elegans HP1 homolog HPL-2 at specific developmental stages. (beds.ac.uk)
- We screened proteins interacting with the C. elegans CnA homolog, TAX-6, by the yeast two-hybrid system. (elsevier.com)
Regulation17
- Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. (nih.gov)
- Despite the evidence that protein misfolding triggers HSF-1 ( 9 , 10 ), the up-regulation of chaperones and activation of HSF-1 is infrequently observed in animal models of protein aggregation and tissues from affected humans ( 11 - 16 ). (pnas.org)
- Arginine methylation of histone and non-histone proteins is involved in transcription regulation and many other cellular processes. (nih.gov)
- We show that inactivation of C. elegans prmt-5 leads to excessive apoptosis in germline following ionizing irradiation, which is due to a CEP-1/p53-dependent up-regulation of the cell death initiator EGL-1. (nih.gov)
- Even though their protein sequences are strongly conserved, their mechanism of regulation is not conserved across yeast, Drosophila , and vertebrates. (biomedcentral.com)
- In this study, we performed an in-depth examination of C. elegans RPG regulation and found nine highly conserved motifs in the upstream regions of C. elegans RPGs using the motif discovery algorithm DME. (biomedcentral.com)
- The C. elegans RasGAPs have thus undergone partial specialization after gene duplication to allow the differential regulation of the RAS/MAPK signaling pathway in different cell types. (uzh.ch)
- Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39. (semanticscholar.org)
- Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). (umassmed.edu)
- In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. (umassmed.edu)
- Regulation by miRNAs often results in down-regulation of target mRNA and protein expression by mechanisms that are yet to be fully elucidated. (core.ac.uk)
- In conclusion, regulation of lin-14 at the mRNA and protein levels can be uncoupled by changes in culture conditions, indicating that miRNA function can be modulated by environment in multicellular organisms. (core.ac.uk)
- In addition to being targeted by miRNAs, these mRNAs are also extensively regulated by RNA-binding proteins (RBPs) through RNA processing, transport, stability, and translation regulation. (prelekara.sk)
- Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans. (biomedsearch.com)
- Heterochromatin protein 1 (HP1) family proteins have a well-characterized role in heterochromatin packaging and gene regulation. (beds.ac.uk)
- CONCLUSIONS: BIR-1, a C. elegans BIRP, is probably not involved in the general regulation of apoptosis but is required for embryonic cytokinesis. (cshl.edu)
- The transcriptional regulation of C. elegans myosin genes is in many respects similar to that of vertebrates. (biologists.org)
Kinase13
- The PHR proteins act as E3 ubiquitin ligases for the dual-leucine-zipper-bearing MAP kinase kinase kinase (DLK MAPKKK) to regulate the signal transduction cascade. (genetics.org)
- Upon binding of receptors to exposed subendothelial ligands, signal transducers (including G-proteins, phospholipase C, and protein kinase C) collaborate to activate the cells. (genetics.org)
- We conclude that programmed cell death in C. elegans is regulated by an alternative splicing event controlled by the SR protein kinase SPK-1. (mit.edu)
- Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. (wikipathways.org)
- Infolgedessen wurde das fadenwurmspezifische Protein GEI-12 als neuer Interaktionspartner der DYRK-Kinase MBK-2 und als wichtiger Regler für die Dynamik der „P granules" und für die Aufrechterhaltung der Keimbahn identifiziert. (hu-berlin.de)
- Consequently, a worm-specific protein GEI-12 was discovered as a novel interaction partner of the DYRK kinase MBK-2 and as an important regulator of P granule dynamics and germline maintenance. (hu-berlin.de)
- Hirose T, Nakano Y, Nagamatsu Y, Misumi T, Ohta H, Ohshima Y (2003) Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans . (springer.com)
- Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. (duke.edu)
- Genetic analysis of one strain revealed an insertion in a gene homologous to Saccharomyces cerevisiae KIN1, which encodes a serine/threonine protein kinase. (duke.edu)
- These findings show that the C. neoformans Kin1 kinase homologue is required for full virulence in disparate hosts and that C. elegans can be used as a substitute host to identify novel factors involved in fungal pathogenesis in mammals. (duke.edu)
- AAK-2 is one of two α isoforms of the AMP-activated protein kinase in Caenorhabditis elegans and is involved in life span maintenance, stress responses, and germ cell cycle arrest upon dauer entry. (elsevier.com)
- cAMP-dependent protein kinase (PKA) regulates numerous cellular processes in eukaryotes in response to extracellular and intracellular signals, via a flexible post-translational modification system. (yu.edu)
- Non-receptor tyrosine-protein kinase TYK2. (wikipedia.org)
Genetics1
- The PTB2 domain of these proteins binds to the cytosolic domains of the Alzheimer's β-amyloid precursor protein APP and related proteins APLP1 and APLP2, generating a highly redundant system that is hard to dissect by reverse genetics. (biologists.org)
Encodes a novel4
- We have identified the spe-12 gene, which encodes a novel protein containing a single transmembrane domain. (genetics.org)
- We demonstrate that dpy-30 encodes a novel nuclear protein of 123 amino acids that is present in both hermaphrodites and males (XO) throughout development. (biologists.org)
- mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes. (biomedsearch.com)
- The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit. (semanticscholar.org)
Developmental10
- In this work, we present the first investigation of the developmental role of VRKs by means of a novel C. elegans vrk-1 mutant allele. (csic.es)
- In situ techniques for targeted protein degradation enable a detailed analysis of developmental events, mechanisms, and functions. (g3journal.org)
- The type I membrane protein EFF-1 is essential for developmental cell fusion. (nature.com)
- Maurer, C. W., Chiorazzi, M. & Shaham, S. Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. (nature.com)
- RUNX proteins are evolutionarily conserved transcription factors known to be involved in various developmental processes. (elsevier.com)
- Caenorhabditis elegans developmental proteins lin-12 (13 copies) and glp-1 (10 copies). (yale.edu)
- Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events. (springer.com)
- Inhibiting HMG-CoA reductase in C. elegans using statins or RNAi leads to developmental arrest and loss of membrane association of a GFP-based prenylation reporter. (gu.se)
- We conclude that inhibitors of HMG-CoA reductase or of farnesyl transferases induce the UPR by inhibiting the prenylation of M57.2 substrates, resulting in developmental arrest in C. elegans. (gu.se)
- The process of gene amplification in Drosophila ovaries provides a means of increasing the amount of template for transcription, thus increasing the amount of protein that can be made over a short developmental period. (mit.edu)
Molecular12
- Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. (nih.gov)
- The elevated levels of heat shock proteins, also termed molecular chaperones because of their involvement in various steps of protein folding, assist the cell in restoring the protein-folding homeostasis after stress exposure ( 20 , 21 ). (pnas.org)
- To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein misfolding. (pnas.org)
- HSF-1 regulates the inducible expression of HS proteins (HSPs), many of which are molecular chaperones that protect the proteome by enhancing folding, suppressing misfolding, and targeting damaged proteins for degradation ( 8 ). (pnas.org)
- The current hypothesis for the induction of chaperones is that elevated levels of misfolded and damaged proteins caused by environmental insults or errors in protein biogenesis titrate the molecular chaperones away from HSF-1 and toward association with misfolded proteins, resulting in the derepression and activation of HSF-1 ( 9 , 10 ). (pnas.org)
- Mitochondria have dedicated molecular chaperones and proteases that promote proper protein folding, complex assembly and quality control. (wikipathways.org)
- We report here the molecular analysis of smg-2 of Caenorhabditis elegans . (asm.org)
- The common modular structure of the Fe65s, composed of a WW domain and two independent phosphotyrosine-binding domains (PTB), PTB1 and PTB2, suggests the function of molecular adaptors for these proteins. (biologists.org)
- Most of the genes encoding the proteins taking part in this complex molecular machinery have been isolated and, in some instances, characterised in C. elegans . (biologists.org)
- Specifically, we report the genetic and molecular characterizations of hrpk-1 and its role in C . elegans development and miRNA-mediated target repression. (prelekara.sk)
- In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. (wikipedia.org)
- In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. (wikipedia.org)
Drosophila3
- Analysis of the genomes of both Drosophila melanogaster and Caenorhabditis elegans has revealed large families of genes that encode potential ionotropic glutamate receptor subunits ( Littleton and Ganetzky, 2000 ). (jneurosci.org)
- Four motifs were partially similar to transcription factor binding sites from C. elegans , Drosophila , yeast, and human. (biomedcentral.com)
- The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. (ebi.ac.uk)
Activity in Caenorhabditis elegans2
- N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo. (nih.gov)
- 7. Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V. nhl-2 Modulates microRNA activity in Caenorhabditis elegans. (prelekara.sk)
Receptor12
- Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts. (nih.gov)
- Sequence analysis of the predicted proteins identified two NMDA and eight non-NMDA receptor subunits. (jneurosci.org)
- Expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling. (csic.es)
- Finally, we present highly penetrant defects from NAA-mediated degradation of the FTZ-F1 nuclear hormone receptor, NHR-25 , during C. elegans uterine-vulval development. (g3journal.org)
- C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking. (semanticscholar.org)
- Additional studies reveal that 5-HIAA functions to inhibit egg laying in a manner dependent on the 5-HT receptor SER-1 and the G protein GOA-1. (iupui.edu)
- Here, we show that ego-2 positively regulates signaling in various tissues via both GLP-1 and the second C. elegans Notch-type receptor, LIN-12. (syr.edu)
- We screened all LRR-containing transmembrane receptors in C. elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C. elegans immune response to Gram-negative and Gram-positive bacterial pathogens. (meta.org)
- Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. (labex-inform.com)
- Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle. (semanticscholar.org)
- Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. (semanticscholar.org)
- The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. (semanticscholar.org)
Pathways4
- To better understand additional signaling pathways that mediate RPM-1's function, we purified RPM-1 and used mass spectrometry to identify RPM-1 binding proteins. (jneurosci.org)
- Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. (springer.com)
- Dissection of genetic pathways in C. elegans. (semanticscholar.org)
- Aside from binding to membranes, the activated FERM domain of ERM proteins can also bind the guanine nucleotide dissociation inhibitor of Rho GTPase (RhoDGI), which suggests that in addition to functioning as a cross-linker, ERM proteins may influence Rho signalling pathways. (wikipedia.org)
Genetic7
- To identify genes involved in protecting cells from programmed cell death in Caenorhabditis elegans, we performed a genetic screen to isolate mutations that cause an increase in the number of programmed cell deaths. (mit.edu)
- To further elucidate the role of GRKs in regulating GPCR-mediated behaviors, we utilized the genetic model system Caenorhabditis elegans Our studies demonstrate that grk-2 loss-of-function strains are egg laying-defective and contain low levels of serotonin (5-HT) and high levels of the 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA). (iupui.edu)
- A genetic approach and the hermaphrodite/male reproductive biology of C. elegans facilitated the identification of a number of genes required for sperm-oocyte interactions at fertilization. (biomedcentral.com)
- Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans. (ox.ac.uk)
- By combining genetic analysis in Caenorhabditis elegans with cellular biochemical experiments in mammalian cells, we showed that: i) loss of CeTOCA proteins reduced the efficiency of Clathrin-mediated endocytosis (CME) in oocytes. (unimi.it)
- Genetic interference with CeTOCAs interacting proteins WSP-1 and WVE-1, and other components of the WVE-1 complex, produced a similar effect. (unimi.it)
- Sydney Brenner promoted Caenorhabditis elegans as a model organism, and subsequent investigations pursued resistance to the nicotinic anthelmintic drug levamisole in C. elegans at a genetic level. (semanticscholar.org)
Cytoplasmic9
- The expression of polyglutamine repeats as green fluorescent protein (GFP)-fusion proteins in body wall muscle cells causes discrete cytoplasmic aggregates that appear early in embryogenesis and correlates with a delay in larval to adult development. (pnas.org)
- mua-3 encodes a predicted 3,767 amino acid protein with a large extracellular domain, a single transmembrane helix, and a smaller cytoplasmic domain. (biomedsearch.com)
- The finding that hUpf3p-X is a shuttling protein provides additional indication that NMD has both nuclear and cytoplasmic components. (asm.org)
- We further investigated the function of lsm-1, which encodes the distinctive protein of the cytoplasmic complex. (pasteur.fr)
- We also observed that under stress, cytoplasmic LSm proteins aggregate into granules in an LSM-1-dependent manner. (pasteur.fr)
- These proteins contain 12 transmembrane helices followed by a cytoplasmic STAS domain at the C terminus. (ebi.ac.uk)
- The sizes of the C. elegans C subunit gene, cytoplasmic mRNA (2.5 kb), and subunit protein are similar to the sizes of the murine Ca gene, mRNA, and polypeptide. (elsevier.com)
- The amino-acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. (wikipedia.org)
- Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins. (wikipedia.org)
MRNA11
- This signaling cascade further regulates the activity of the CCAAT/enhancer binding protein (C/EBP), CEBP-1 , via a mechanism involving 3′-UTR-mediated mRNA decay. (genetics.org)
- spe-12 mRNA is expressed in the sperm-producing germ line and the protein localizes to the spermatid cell surface. (genetics.org)
- Nonsense-mediated mRNA decay (NMD), also called mRNA surveillance, is an important pathway used by all organisms that have been tested to degrade mRNAs that prematurely terminate translation and, as a consequence, eliminate the production of aberrant proteins that could be potentially harmful. (asm.org)
- Interestingly, human orthologues to S. cerevisiae Upf3p ( C. elegans SMG-4) derive from two genes, one of which is X-linked and both of which generate multiple isoforms due to alternative pre-mRNA splicing. (asm.org)
- In order to cope with the generation of PTCs and their potential to result in deleterious proteins that function in new or dominant-negative ways, mammalian cells have evolved a pathway called nonsense-mediated mRNA decay (NMD) or mRNA surveillance (reviewed in references 20 , 28 , 30 , 31 , and 32 ). (asm.org)
- Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. (umassmed.edu)
- In Caenorhabditis elegans, the lin-4 miRNA recognizes multiple sites in the lin-14 3′UTR and directs mRNA degradation and translational repression, but it is unclear how these processes are coupled. (core.ac.uk)
- In this study, we demonstrate that nutrient deprivation results in loss of lin-14 mRNA, but not protein, repression. (core.ac.uk)
- Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. (prelekara.sk)
- The 5′ end of the C. elegans C subunit mRNA is produced by the trans-splicing of the C gene transcript to a 22-base pair C. elegans leader sequence originally described by Krause, M., and Hirsh, D. ((1987) Cell 49, 753-761). (elsevier.com)
- This compound could increase the mRNA level of stress response gene gst-4 , and the mRNA and protein expression level of heat shock protein hsp-16.2 under heat stress. (mdpi.com)
RNAi5
- Through a comprehensive functional study of the LSm family members, we found that lsm-1 and lsm-3 are not essential for C. elegans viability, but their perturbation, by RNAi or mutations, produces defects in development, reproduction, and motility. (pasteur.fr)
- An RNAi-based screen of putative ALG-1 Argonaute interactors has identified a role for a conserved RNA binding protein, HRPK-1, in modulating miRNA activity during C . elegans development. (prelekara.sk)
- 10. Parry DH, Xu J, Ruvkun G. A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes. (prelekara.sk)
- RNA interference (RNAi) was employed in an attempt to determine the biological function of UBC-2 interacting proteins in vivo. (ubc.ca)
- RNAi with mca-1 produced a subtle body shortening phenotype, although genes encoding UBC-2 interacting proteins appear to be non-essential. (ubc.ca)
Homologue3
- Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. (uzh.ch)
- Overexpression of hCED-6 rescues the engulfment defect of ced-6 mutants in C. elegans significantly, suggesting that hCED-6 is a functional homologue of C. elegans CED-6. (uzh.ch)
- We found that AAK-2 was phosphorylated at threonine 243 in response to paraquat treatment and that this phosphorylation depends on PAR-4, the C. elegans LKB1 homologue. (elsevier.com)
Mutation2
- Both aak-2 mutation and par-4 knockdown increased the sensitivity of C. elegans worms to paraquat, and the double deficiency did not further increase sensitivity, indicating that aak-2 and par-4 act in a linear pathway. (elsevier.com)
- Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans. (babraham.ac.uk)
Regulates4
- In this study, we examine whether neuronal activity also regulates the cellular response to chronic expression of misfolded proteins. (pnas.org)
- Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. (wikipathways.org)
- Previous studies in Caenorhabditis elegans showed that RPM-1 (Regulator of Presynaptic Morphology-1) regulates axon termination and synapse formation. (jneurosci.org)
- Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. (springer.com)
Interactions10
- In C. elegans, early embryogenesis provides an attractive model system for mapping in vivo protein interactions. (hu-berlin.de)
- In order to accurately identify specific interactions in C. elegans embryos, a new quantitative approach was developed combining in vivo expressed GFP fusion proteins with label-free interaction proteomics. (hu-berlin.de)
- As a result, this study generated a pilot embryo in vivo interaction network composed of 559 interactions among 472 proteins. (hu-berlin.de)
- We demonstrate using immunoprecipitations of epitope-tagged proteins transiently produced in HeLa cells that hUpf2p interacts with hUpf1p, hUpf3p-X, and hUpf3p, and we define the domains required for the interactions. (asm.org)
- GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins. (iupui.edu)
- The bimolecular fluorescence complementation (BiFC) assay is a powerful tool for visualizing and identifying protein interactions in living cells. (researchwithrowan.com)
- BACKGROUND: Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. (uu.nl)
- We validated the ability of our approach to identify bona fide protein interactions by identifying the known LGL-1 interaction partners PAR-6 and PKC-3. (uu.nl)
- All interactions identified by yeast two-hybrid assays were confirmed by in vitro binding assays using purified proteins. (fujita-hu.ac.jp)
- After getting my Master's degree at Imperial College London, I moved "oop north", to Durham University for my PhD. I used the C. elegans: E. coli (host/microbe) model to look at interactions between host and gut bacteria - focussing on how particular metabolites might influence health and ageing. (babraham.ac.uk)
Interaction8
- UEV-3 can bind PMK-3 in heterologous protein interaction assays. (genetics.org)
- This strategy was applied to studying the interaction partners of eight bait proteins involved in essential biological processes during early embryogenesis. (hu-berlin.de)
- We define a RAE-1 binding region in RPM-1, and show that this binding interaction is conserved and also occurs between Rae1 and the human ortholog of RPM-1 called Pam (protein associated with Myc). (jneurosci.org)
- We have mapped the interaction of C. elegans (Ce)RAE-1 to a conserved RAE-1 binding motif in RPM-1, and shown that the human ortholog of RPM-1 [called Protein Associated with Myc (Pam) or Myc-Binding Protein (MYCBP)-2] interacts with rat Rae1 in a similar manner. (jneurosci.org)
- Purification of the Discs large protein DLG-1 identified several candidate interaction partners, including the AAA-type ATPase ATAD-3 and the uncharacterized protein MAPH-1.1. (uu.nl)
- We have identified the domains that mediate the DLG-1/ATAD-3 interaction, and show that this interaction contributes to C. elegans development. (uu.nl)
- Finally, we conclude that MAPH-1.1 is a microtubule-associated protein of the MAP1 family and a candidate neuron-specific interaction partner of DLG-1. (uu.nl)
- Since DSK-2 represented 60% of the putative interactors isolated from the screen, this project focused on the interaction of UBC-2 and DSK-2, and demonstrated a novel interaction between an E2 and an ubiquitin-domain protein (UDP) in vitro. (ubc.ca)
Mutants4
- Thermosensory Neuronal Mutants Suppress Aggregation of Polyglutamine Expansion Proteins Expressed in Intestinal Cells of C. elegans . (pnas.org)
- Despite similarities in the sequences of SMG-2 and Upf1p, expression of Upf1p in C. elegans does not rescue smg-2 mutants. (asm.org)
- Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. (elsevier.com)
- To identify proteins that interact with UNC-17/VAChT, we screened for mutations that suppress the uncoordinated phenotype of UNC-17(G347R) mutants. (ox.ac.uk)
Nematodes1
- Furthermore, we demonstrate that AMX-2 is the primary monoamine oxidase that metabolizes 5-HT in C. elegans, and we also found that grk-2 loss-of-function strains have abnormally high levels of AMX-2 compared with wild-type nematodes. (iupui.edu)
Saccharomyces2
- To date, human (h) Upf1 protein (p) (hUpf1p), a group 1 RNA helicase named after its Saccharomyces cerevisiae orthologue that functions in both translation termination and NMD, has been the only factor shown to be required for NMD in mammalian cells. (asm.org)
- Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. (ebi.ac.uk)
Transmembrane protein1
- SPE-9 is a transmembrane protein with a predicted extracellular domain that contains ten epidermal growth factor (EGF)-like motifs. (biomedcentral.com)
Membrane Proteins2
- We also show that during mitosis, UNC-84 remains at the nuclear periphery until late anaphase, similar to known inner nuclear membrane proteins. (elsevier.com)
- For cytoskeleton-membrane cross-linking, the dormant molecules becomes activated and the FERM domain attaches to the membrane by binding specific membrane proteins, while the last 34 residues of the tail bind actin filaments. (wikipedia.org)
Extracellular3
- Banse SA, Hunter CP (2012) Vampiric isolation of extracellular fluid from Caenorhabditis elegans . (springer.com)
- The extracellular domain contains four distinct protein modules: 5 low density lipoprotein type A, 52 epidermal growth factor, 1 von Willebrand factor A, and 2 sea urchin-enterokinase-agrin modules. (biomedsearch.com)
- Calcium-dependent serine proteinase (CASP) which degrades the extracellular matrix proteins type I and IV collagen and fibronectin (1 copy). (yale.edu)
Transcription5
- The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. (wikipathways.org)
- The vaccinia-related kinases (VRKs) are highly conserved throughout the animal kingdom and phosphorylate several chromatin proteins and transcription factors. (csic.es)
- Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. (semanticscholar.org)
- In this report we demonstrate that muscles of C. elegans that developed in space, during the European Space Agency (ESA) DELTA mission, display decreased expression of the transcription factors controlling both body wall and pharyngeal muscle myogenesis as well as decreased expression of muscle-specific MHCs. (biologists.org)
- The failure of activating the transcription factor DAF-16 might explain why this compound could not act as aspirin to extend the lifespan of C. elegans . (mdpi.com)
Subunit1
- dynein recruitment to the cell cortex by a heterotrimeric G-protein α subunit in complex with a TPR-GoLoco motif protein (GPR-1/2, Pins, LGN) and coiled-coil protein (LIN-5, Mud, NuMA). (uu.nl)
Family of proteins2
- The Caenorhabditis elegans Regulator of Presynaptic Morphology (RPM)-1 is a member of a conserved family of proteins called Pam/Highwire/RPM-1 (PHR) proteins. (jneurosci.org)
- This family of proteins was first identified in Caenorhabditis elegans. (ebi.ac.uk)
Lifespan4
- S. Abbas and M. Wink, "Epigallocatechin gallate from green tea ( Camellia sinensis ) increases lifespan and stress resistance in Caenorhabditis elegans ," Planta Medica , vol. 75, no. 3, pp. 216-221, 2009. (hindawi.com)
- A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans ," Free Radical Research , vol. 44, no. 7, pp. 813-820, 2010. (hindawi.com)
- To resolve this issue, studies were performed to determine whether an Imp-L2-like protein exists in C. elegans, and whether it prolongs lifespan during periods of stress. (cornell.edu)
- One of the compounds, 5-(bis(3-methylbut-2-en-1-yl)amino)-2-hydroxybenzoic acid, moderately increased the survival of C. elegans under heat stress, but could not extend the lifespan under optimum conditions. (mdpi.com)
20021
- Fares H, Grant B (2002) Deciphering endocytosis in Caenorhabditis elegans . (springer.com)
Fluorescent proteins1
- This assay is based on the principle of protein-fragment complementation, using two nonfluorescent fragments derived from fluorescent proteins. (researchwithrowan.com)
Cells20
- Here we show, in animals expressing polyglutamine expansion proteins and mutant SOD-1 G93A in intestinal or muscle cells, that the nervous system does indeed control the cellular response to misfolded proteins. (pnas.org)
- The inability to maintain protein quality control has detrimental effects on cell physiology and function, and is the basis of diseases of protein conformation, including Huntington disease, Parkinson disease, Alzheimer's disease, cancer, and type II diabetes, in which cells accumulate misfolded and aggregated proteins ( 1 , 2 ). (pnas.org)
- To inhibit aggregation and toxicity, cells and organisms have evolved multiple stress responsive networks that detect and respond to the accumulation of damaged proteins ( 3 - 8 ). (pnas.org)
- Work in cultured mammalian cells and Caenorhabditis elegans has yielded clues to the mechanisms linking perturbations in the protein-folding environment in the mitochondrial matrix to the expression of nuclear genes encoding mitochondrial proteins. (wikipathways.org)
- Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. (springer.com)
- We propose that the patterned expression of heat shock protein is caused by a diffusion-driven instability within the pseudocoelom, or fluid-filled cavity, that borders the intestinal cells in C. elegans . (springer.com)
- Ribosomes are essential components of all cells, prokaryotic and eukaryotic, and the sequences of ribosomal protein genes (RPGs) are conserved across all eukaryotes. (biomedcentral.com)
- Because ribosomes are necessary for the expression of all protein-coding genes, they are highly expressed in replicating cells. (biomedcentral.com)
- GFP fusion protein in the ventral nerve cord and vulva precursor cells restores vulva and uterus formation, suggesting both cell autonomous and non-autonomous roles of VRK-1. (csic.es)
- We take advantage of the photostability of NAA to demonstrate via quantitative high-resolution microscopy that rapid degradation of target proteins can be detected in single cells within 30 min of exposure. (g3journal.org)
- Our previous analysis of the engulfment gene ced-6 in Caenorhabditis elegans has suggested that CED-6 is an adaptor protein that participates in a signal transduction pathway that mediates the specific recognition and engulfment of apoptotic cells [1]. (uzh.ch)
- Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. (semanticscholar.org)
- UNC-84 protein is first detected at the 26-cell stage and thereafter is present in most cells during development and in adults. (elsevier.com)
- When two fragments are brought together in living cells by tethering each to one of a pair of interacting proteins, fluorescence is restored. (researchwithrowan.com)
- ii) CeTOCA proteins localize to cell-cell junctions and are required for proper embryonic morphogenesis, to position hypodermal cells and to organize junctional actin and the junction-associated protein AJM-1. (unimi.it)
- This protein was first detected in 4-6 cells of the clonal E lineage of 100-cell embryos. (utmb.edu)
- FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. (ecu.edu)
- Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. (babraham.ac.uk)
- In this study, we therefore employed space flown C. elegans to confirm and extend the findings made with cultured embryonic avian muscle cells. (biologists.org)
- Princeton University researchers have discovered that learned behaviors can be inherited for multiple generations in C. elegans, transmitted from parent to progeny via eggs and sperm cells. (news-medical.net)
Functional4
- M. Memarpoor-Yazdi, H. Mahaki, and H. Zare-Zardini, "Antioxidant activity of protein hydrolysates and purified peptides from Zizyphus jujuba fruits," Journal of Functional Foods , vol. 5, no. 1, pp. 62-70, 2013. (hindawi.com)
- In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evolution. (epfl.ch)
- Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans. (semanticscholar.org)
- Fertilization in Caenorhabditis elegans requires functional SPE-9 protein in sperm. (biomedcentral.com)
Chromatin1
- In eukaryotes, these processes are often associated with characteristic epigenetic changes brought about by the activity of chromatin-associated proteins and enzymes that influence the transition between chromatin states, thereby influencing transcriptional activity. (beds.ac.uk)
Organism1
- p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
Actin6
- The TOCA family of F-BAR-containing proteins bind to and remodel lipid bilayers via their conserved F-BAR domains, and regulate actin dynamics via their N-Wasp binding SH3 domains. (unimi.it)
- Thus, these proteins are predicted to play a pivotal role in coordinating membrane traffic with actin dynamics during cell migration and tissue morphogenesis. (unimi.it)
- Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. (springer.com)
- ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, which binds F-actin. (wikipedia.org)
- FERM domain containing proteins include: Band 4.1, which links the spectrin-actin cytoskeleton of erythrocytes to the plasma membrane. (wikipedia.org)
- Filopodin, a slime mould protein that binds actin and which is involved in the control of cell motility and chemotaxis. (wikipedia.org)
Yeast5
- Belle A, Tanay A, Bitincka L, Shamir R, O'Shea EK (2006) Quantification of protein half-lives in the budding yeast proteome. (springer.com)
- In order to identify proteins that interact with UBC-2, a yeast two-hybrid analysis was employed. (ubc.ca)
- Putative TJBC-2 interacting proteins identified include: a ubiquitin-like budding yeast DSK2 ortholog referred to as DSK-2, two RING finger proteins, a protein containing a FYVE domain, a calcium ATPase called MCA-1, and ubiquitin. (ubc.ca)
- Both the marked structural diversity of IAPs and the identification of BIR-containing proteins (BIRPs) in yeast, however, have led to the suggestion that BIRPs might play roles in other, as yet unidentified, cellular processes besides apoptosis. (cshl.edu)
- By yeast two-hybrid screening, we found three novel interactors (UNC-95, LIM-8, and LIM-9) for UNC-97/PINCH in Caenorhabditis elegans. (fujita-hu.ac.jp)
Highly conserved1
- BACKGROUND: Inhibitor of apoptosis proteins (IAPs) suppress apoptotic cell death in several model systems and are highly conserved between insects and mammals. (cshl.edu)
Embryos1
- In early Caenorhabditis elegans embryos, VRK-1 is required for proper nuclear envelope formation. (csic.es)
Vivo3
- In C. elegans bietet die frühe Embryogenese ein attraktives Modellsystem, um Wechselwirkungen von Proteinen in vivo zu entschlüsseln. (hu-berlin.de)
- Zur präzisen Identifizierung von spezifischen Interaktionen im C. elegans Embryo wurde ein neuer quantitativer Ansatz entwickelt, welcher die Expression von Fusionsproteinen an grün fluoreszierendes Protein in vivo mit markierungsfreier Interaktionsproteomik kombiniert. (hu-berlin.de)
- Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties. (inserm.fr)
Embryonic1
- Ribosomal protein genes (RPGs) are essential, tightly regulated, and highly expressed during embryonic development and cell growth. (biomedcentral.com)
Endogenous2
- Note: Depending on protein expression and specificity of antibody, this protocol can also be used to immunoprecipitate endogenous proteins. (bio-protocol.org)
- We show that endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear envelope and that the envelope localization of UNC-84 requires Ce-lamin. (elsevier.com)
Resistance4
- W. Chen, L. Rezaizadehnajafi, and M. Wink, "Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans ," Journal of Pharmacy and Pharmacology , vol. 65, no. 5, pp. 682-688, 2013. (hindawi.com)
- Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. (mit.edu)
- Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans. (semanticscholar.org)
- In lev-8 and lev-1 mutant C. elegans, levamisole resistance is associated with reductions in levamisole-activated whole muscle cell currents. (semanticscholar.org)
Myosin thick filaments1
- Our previous studies showed that UNC-98, a C2H2 Zn finger protein, acts as a linkage between UNC-97, an integrin-associated protein, and MHC A in myosin thick filaments. (fujita-hu.ac.jp)
Mutations3
- The efficiency of protein folding can be affected by several factors, including primary sequence mutations or alterations in the cellular environment. (pnas.org)
- Mutations in the Caenorhabditis elegans unc-84 gene cause defects in nuclear migration and anchoring. (elsevier.com)
- These mutations allowed us to establish that the V0 sector mediates secretion of Hedgehog-related proteins. (rupress.org)
Pathway5
- All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. (uzh.ch)
- Thus, CED-6, and the CED-6 signal transduction pathway, might be conserved from C. elegans to humans and are present in most, if not all, human tissues. (uzh.ch)
- Using Caenorhabditis elegans , we characterize a novel apical secretion pathway involving multivesicularbodies and the release of exosomes at the apical plasma membrane. (rupress.org)
- A major route for protein degradation occurs via the ubiquitin-proteasome pathway. (ubc.ca)
- They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway that leads to the synthesis of farnesyl pyrophosphate, a precursor for cholesterol synthesis and the source of lipid moieties for protein prenylation. (gu.se)
Escherichia1
- Escherichia coli hypothetical protein ychM. (ebi.ac.uk)
Genome2
- Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. Elegans Ageing. (babraham.ac.uk)
- By cDNA library screening, bioinformatic searches, and genome/transcriptome data mining for proteins with Arg-Phe-Gly sequences flanked by N- and C-terminal tri-, di-, or mono-basic residues, we and others identified 31 genes encoding FLPs in C. elegans ( 10 , 12 ). (frontiersin.org)
Cellular3
- We suggest that this intra-cellular domain of TRA-2A promotes hermaphrodite development by negatively regulating the FEM proteins. (biologists.org)
- The antigenic determinant shared by these proteins could represent a common structural feature of importance to the localization or cellular specificity of these proteins. (rupress.org)
- Changes in the cellular distribution of gamete proteins could also regulate activity and access to other interacting molecules. (biomedcentral.com)
Phenotype1
- Voutev and Hubbard 2008 ) in Caenorhabditis elegans allow tissue-specific study of gene products, but the persistence of the protein of interest following RNA depletion or DNA recombination can delay manifestation of an otherwise acute phenotype. (g3journal.org)
Mammals1
- The conserved PHR proteins play important roles in many aspects of axon and synapse development from C. elegans to mammals. (genetics.org)
Homeostasis2
- The altered homeostasis associated with polyglutamine aggregates causes both the sequestration of an otherwise soluble protein with shorter arrays of glutamine repeats and the relocalization of a nuclear glutamine-rich protein. (pnas.org)
- The mitochondrial UPR - protecting organelle protein homeostasis. (wikipathways.org)
Larvae1
- We also demonstrate that K-NAA, the water-soluble, potassium salt of NAA, can be combined with microfluidics for targeted protein degradation in C. elegans larvae. (g3journal.org)
Oxidative stress1
- We show that the Caenorhabditis elegans SIR-2.2 and SIR-2.3 orthologs of SIRT4 are ubiquitously expressed, also localize to mitochondria and function during oxidative stress. (edu.sa)
Epithelial1
- Here, we report that dismantling and clearance of a morphologically complex Caenorhabditis elegans epithelial cell requires separate cell soma, proximal and distal process programmes. (nature.com)
Isoforms2
Fragments2
- The formation of aggregates in vitro depends on the appearance of fragments of huntingtin containing polyglutamine repeats, consistent with the proposal that protein aggregate formation is generally preceded by the appearance of an initial seed of misfolded protein ( 16 ). (pnas.org)
- However, peptide fragments of the proteins are not antigenic, thus the determinant is likely to be dependent on polypeptide conformation. (rupress.org)
Kinases2
- Small protein tags such as ubiquitin have also been shown to control the activation of kinases. (genetics.org)
- The spk-1 gene encodes a protein homologous to serine-arginine-rich (SR) protein kinases, which are thought to regulate splicing. (mit.edu)