Cadaverine: A foul-smelling diamine formed by bacterial decarboxylation of lysine.Diamines: Organic chemicals which have two amino groups in an aliphatic chain.Putrescine: A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.PolyaminesSelenomonas: Curved bacteria, usually crescent-shaped rods, with ends often tapered, occurring singly, in pairs, or short chains. They are non-encapsulated, non-sporing, motile, and ferment glucose. Selenomonas are found mainly in the human buccal cavity, the rumen of herbivores, and the cecum of pigs and several rodents. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Spermidine: A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.Spermine: A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.Carboxy-Lyases: Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.Muramic Acids: Compounds consisting of glucosamine and lactate joined by an ether linkage. They occur naturally as N-acetyl derivatives in peptidoglycan, the characteristic polysaccharide composing bacterial cell walls. (From Dorland, 28th ed)Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.Spermidine Synthase: An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.Veillonella: A genus of gram-negative, anaerobic cocci parasitic in the mouth and in the intestinal and respiratory tracts of man and other animals.Gram-Negative Anaerobic Bacteria: A large group of anaerobic bacteria which show up as pink (negative) when treated by the Gram-staining method.Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.PeptidoglycanDiaminopimelic AcidOrnithine Decarboxylase: A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.Vibrio vulnificus: A species of halophilic bacteria in the genus VIBRIO, which lives in warm SEAWATER. It can cause infections in those who eat raw contaminated seafood or have open wounds exposed to seawater.Lysine: An essential amino acid. It is often added to animal feed.Transglutaminases: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Antiporters: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Salamandridae: A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.Dictionaries, ChemicalAgrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Biogenic Polyamines: Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.Tripterygium: A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.Poetry as Topic: Literary and oral genre expressing meaning via symbolism and following formal or informal patterns.Geranium: A plant genus of the family GERANIACEAE. Geranium is also used as a common name for PELARGONIUM.PoetryNewspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)PaintBeetles: INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Piperidines: A family of hexahydropyridines.Amino Acids, Neutral: Amino acids with uncharged R groups or side chains.Corynebacterium glutamicum: A species of gram-positive, asporogenous, non-pathogenic, soil bacteria that produces GLUTAMIC ACID.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Corynebacterium: A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.Nylons: Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Molasses: The syrup remaining after sugar is crystallized out of SUGARCANE or sugar beet juice. It is also used in ANIMAL FEED, and in a fermented form, is used to make industrial ETHYL ALCOHOL and ALCOHOLIC BEVERAGES.

Distinct sensitivities of OmpF and PhoE porins to charged modulators. (1/290)

The inhibition of the anion-selective PhoE porin by ATP and of the cation-selective OmpF porin by polyamines has been previously documented. In the present study, we have extended the comparison of the inhibitor-porin pairs by investigating the effect of anions (ATP and aspartate) and positively charged polyamines (spermine and cadaverine) on both OmpF and PhoE with the patch-clamp technique, and by comparing directly the gating kinetics of the channels modulated by their respective substrates. The novel findings reported here are (1) that the activity of PhoE is completely unaffected by polyamines, and (2) that the kinetic changes induced by ATP on PhoE or polyamines on OmpF suggest different mechanisms of inhibition. ATP induces a high degree of flickering in the PhoE-mediated current and appears to behave as a blocker of ion flow during its presumed transport through PhoE. Polyamines modulate the kinetics of openings and closings of OmpF, in addition to promoting a blocker-like flickering activity. The strong correlation between sensitivity to inhibitors and ion selectivity suggests that some common molecular determinants are involved in these two properties and is in agreement with the hypothesis that polyamines bind inside the pore of cationic porins.  (+info)

Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. (2/290)

The 55-kDa receptor for tumor necrosis factor (TR55) triggers multiple signaling cascades initiated by adapter proteins like TRADD and FAN. By use of the primary amine monodansylcadaverine (MDC), we addressed the functional role of tumor necrosis factor (TNF) receptor internalization for intracellular signal distribution. We show that MDC does not prevent the interaction of the p55 TNF receptor (TR55) with FAN and TRADD. Furthermore, the activation of plasmamembrane-associated neutral sphingomyelinase activation as well as the stimulation of proline-directed protein kinases were not affected in MDC-treated cells. In contrast, activation of signaling enzymes that are linked to the "death domain" of TR55, like acid sphingomyelinase and c-Jun-N-terminal protein kinase as well as TNF signaling of apoptosis in U937 and L929 cells, are blocked in the presence of MDC. The results of our study suggest a role of TR55 internalization for the activation of select TR55 death domain signaling pathways including those leading to apoptosis.  (+info)

Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans. (3/290)

The diamines putrescine, cadaverine, and diaminopropane stimulate cephamycin biosynthesis in Nocardia lactamdurans, in shake flasks and fermentors, without altering cell growth. Intracellular levels of the P7 protein (a component of the methoxylation system involved in cephamycin biosynthesis) were increased by diaminopropane, as shown by immunoblotting studies. Lysine-6-aminotransferase and piperideine-6-carboxylate dehydrogenase activities involved in biosynthesis of the alpha-aminoadipic acid precursor were also greatly stimulated. The diamine stimulatory effect is exerted at the transcriptional level, as shown by low-resolution S1 protection studies. The transcript corresponding to the pcbAB gene and to a lesser extent also the lat transcript were significantly increased in diaminopropane-supplemented cultures, whereas transcription from the cefD promoter was not affected. Coupling of the lat and pcbAB promoters to the reporter xylE gene showed that expression from the lat and pcbAB promoters was increased by addition of diaminopropane in Streptomyces lividans. Intracellular accumulation of diamines in Nocardia may be a signal to trigger antibiotic production.  (+info)

Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. (4/290)

Ehrlichia chaffeensis and E. sennetsu are genetically divergent obligatory intracellular bacteria of human monocytes and macrophages, and the human granulocytic ehrlichiosis (HGE) agent is an obligatory intracellular bacterium of granulocytes. Infection with both E. chaffeensis and E. sennetsu, but not HGE agent, in the acute monocytic leukemia cell line THP-1 almost completely inhibited by treatment with deferoxamine, a cell-permeable iron chelator. Transferrin receptors (TfRs) accumulated on both E. chaffeensis and E. sennetsu, but not HGE agent, inclusions in THP-1 cells or the cells of the promyelocytic leukemia cell line HL-60. Reverse transcription-PCR showed an increase in the level of TfR mRNA 6 h postinfection which peaked at 24 h postinfection with both E. chaffeensis and E. sennetsu infection in THP-1 or HL-60 cells. In contrast, HGE agent in THP-1 or HL-60 cells induced no increase in TfR mRNA levels. Heat treatment of E. chaffeensis or the addition of monodansylcadaverine, a transglutaminase inhibitor, 3 h prior to infection inhibited the up-regulation of TfR mRNA. The addition of oxytetracycline 6 h after E. chaffeensis infection caused a decrease in TfR mRNA which returned to the basal level by 24 h postinfection. These results indicate that both internalization and continuous proliferation of ehrlichial organisms or the production of ehrlichial proteins are required for the up-regulation of TfR mRNA. Results of electrophoretic mobility shift assays showed that both E. chaffeensis and E. sennetsu infection increased the binding activity of iron-responsive protein 1 (IRP-1) to the iron-responsive element at 6 h postinfection and remained elevated at 24 h postinfection. However, HGE agent infection had no effect on IRP-1 binding activity. This result suggests that activation of IRP-1 and subsequent stabilization of TfR mRNA comprise the mechanism of TfR mRNA up-regulation by E. chaffeensis and E. sennetsu infection.  (+info)

Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts. (5/290)

Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.  (+info)

Divalent cation-, nucleotide-, and polymerization-dependent changes in the conformation of subdomain 2 of actin. (6/290)

Conformational changes in subdomain 2 of actin were investigated using fluorescence probes dansyl cadaverine (DC) or dansyl ethylenediamine (DED) covalently attached to Gln41. Examination of changes in the fluorescence emission spectra as a function of time during Ca2+/Mg2+ and ATP/ADP exchange at the high-affinity site for divalent cation-nucleotide complex in G-actin confirmed a profound influence of the type of nucleotide but failed to detect a significant cation-dependent difference in the environment of Gln41. No significant difference between Ca- and Mg-actin was also seen in the magnitude of the fluorescence changes resulting from the polymerization of these two actin forms. Evidence is presented that earlier reported cation-dependent differences in the conformation of the loop 38-52 may be related to time-dependent changes in the conformation of subdomain 2 in DED- or DC-labeled G-actin, accelerated by substitution of Mg2+ for Ca2+ in CaATP-G-actin and, in particular, by conversion of MgATP- into MgADP-G-actin. These spontaneous changes are associated with a denaturation-driven release of the bound nucleotide that is promoted by two effects of DED or DC labeling: lowered affinity of actin for nucleotide and acceleration of ATP hydrolysis on MgATP-G-actin that converts it into a less stable MgADP form. Evidence is presented that the changes in the environment of Gln41 accompanying actin polymerization result in part from the release of Pi after the hydrolysis of ATP on the polymer. A similarity of this change to that accompanying replacement of the bound ATP with ADP in G-actin is discussed.  (+info)

Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin. (7/290)

Thymosin beta(4) possesses actin-sequestering activity and, like transglutaminases, is supposed to be involved in cellular events like angiogenesis, blood coagulation, apoptosis and wound healing. Thymosin beta(4) serves as a specific glutaminyl substrate for transglutaminase and can be fluorescently labeled with dansylcadaverine. Two (Gln-23 and Gln-36) of the three glutamine residues were mainly involved in the transglutaminase reaction, while the third glutaminyl residue (Gln-39) was derivatized with a low efficiency. Labeled derivatives were able to inhibit polymerization of G-actin and could be cross-linked to G-actin by 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. Fluorescently labeled thymosin beta(4) may serve as a useful tool for further investigations in cell biology. Thymosin beta(4) could provide a specific glutaminyl substrate for transglutaminase in vivo, because of the fast reaction observed in vitro occurring at thymosin beta(4) concentrations which are found inside cells. Taking these data together, it is tempting to speculate that thymosin beta(4) may serve as a glutaminyl substrate for transglutaminases in vivo and play an important role in transglutaminase-related processes.  (+info)

Covalent linkage of polyamines to peptidoglycan in Anaerovibrio lipolytica. (8/290)

Spermidine and cadaverine were found to be constituents of the cell wall peptidoglycan of Anaerovibrio lipolytica, a strictly anaerobic bacterium. The peptidoglycan was degraded with the N-acetylmuramyl-L-alanine amidase and endopeptidase into two peptide fragments, peptide I and peptide II, at a molar ratio of 4:1. Peptides I and II were identified as L-alanine-D-glutamic acid(alphacadaverine)gammameso-diaminopimelic acid (DAP)-D-alanine and L-alanine-D-glutamic acid(alphaspermidine)gammameso-DAP-D-alanine, respectively. The N(1)-amino group of spermidine was linked to the alpha-carboxyl group of the D-glutamic acid residue of peptide II.  (+info)

In vitro tests using mice found that piperidine formed from cadaverine in the large intestine; it was assumed to be created from cadaverine by intestinal bacteria.[2] No formation of piperidine from cadaverine was detected in the brain.[2]. ...
Limitation of natural sources, especially of fossil resources, for base material that is currently used to produce polyamides and related composites together with the increasing demand of these products, promotes the search for renewable sources of the base material. Fermentation by genetically engineered bacteria gains increasing interest as one of these possible sources. Cadaverine is a biogenic amine that can be produced by Corynebacterium glutamicum from the amino acid lysine by heterologous expression of a lysine decarboxylase from Escherichia coli. Overexpression of the patA and patD genes from Escherichia coli in Corynebacterium glutamicum enables the latter to further metabolize cadaverine to 5 aminovalerate (5AVA), which is a potential base material for the production of nylon 5 and a C5 platform for the synthesis of base materials for other polyamides. Commercial Opportunities Chemical industry is facing an increasing demand on polyamides and related composites, whereas in contrast the ...
I just found out that my semen has cadaverine and putrescine . Cadaverine is a foul-smelling compound produced during putrefaction of animal tissue. The two compounds are largely responsible for the foul odor of putrefying flesh . The two compounds are also responsible for the smell and flavor of semen.. Please move to the appropriate section. Whichever that may be ...
Two genes,LAT1andOCT1, are likely to be involved in polyamine transport in Arabidopsis. Endogenous spermine levels modulate their expression and determine the sensitivity to cadaverine. Arabidopsis sp
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I think like you said he may have been to the apartment for the reason you said and seen the 3 children as he decribes. Happy and content and in a state where he felt that him and kate could slip off for their fun together. I cant see that if the children werent in a contented state that they would have slipped off to another room for some fun time. The child could have interrupted them which made her angry and most likely him angry also and he left. Then as you said she started to jump up and down on the chair shouting what she had seen. Thats when it happened and possibly then with shock and trying to control the other children she didnt immediately reach for the child. She may even have feared for the safety of the other 2. Maybe she has an uncontrollable anger issue that leaves her in such a state that it took a while for the anormaty of she done to register. He may have been returning to the tennis court when he or returning to see if she was ok after initially storming out after the ...
1,3-Diaminopentane 589-37-7 NMR spectrum, 1,3-Diaminopentane H-NMR spectral analysis, 1,3-Diaminopentane C-NMR spectral analysis ect.
ATCC <- M. Rogosa, VR4 <- R. Fuller. Pig gut; country of origin unknown; sampling date: before 22.08.1990. Type strain. Taxonomy/description (1300, 3245, 5143, 5145). Sequence accession no. complete genome: CP001859. Phylogeny (5145). Murein: A31, alpha-carboxyl group of D-glutamic acid is substituted by cadaverine. (Medium 414, 37°C, anaerobic or Medium 110, 37°C, anaerobic or Medium 693, 37°C, anaerobic ...
H. Seidel-Rüfer, OW8. Brewery waste; country of origin unknown. Taxonomy/description (3896). Murein: A31, alpha-carboxyl group of glutamic acid is substituted by cadaverine (3896). (Medium 58 + NBB concentrate, 28°C, anaerobic ...
A list of 11 letter words that begin with C in the enable uncensored word list. cabbageworm cabinetries cabinetwork cachinnated cachinnates cacodemonic cacomistles cacophonies cacophonous cadastrally cadaverines caddishness caddisworms cafetoriums caffeinated cageynesses cajolements cakewalkers cakewalking calamanders etc.
The invention relates to recombinant microorganisms in which polynucleotides which code for lysine decarboxylase are enhanced and, using which, cadaverine (1,5-diaminopentane) is produced fermentatively, with the carbon source used preferably being renewable raw materials such as, for example, glucose, sucrose, molasses and the like.
The polyamines spermine, spermidine, putrescine, cadaverine, etc. have been implicated in a variety of cellular functions. However, details of their mode of interaction with other ubiquitous biomolecules is not known. We have solved a few structures of polyamine-amino acid complexes to understand the nature and mode of their interactions. Here we report the structure of a complex of putrescine with DL-glutamic acid. Comparison of the structure with the structure of putrescine-L-glutamic acid complex reveals the high degree of similarity in the mode of interaction in the two complexes. Despite the presence of a centre of symmetry in the present case, the arrangement of molecules is strikingly similar to the L-glutamic acid complex.. ...
The epidermal growth factor receptor (EGFR) has been shown to be a valid therapeutic target in breast cancer. This provides a strong rationale for the use of gefitinib, an inhibitor of the EGFR tyrosine kinase, in treatment of EGFR expressing breast cancers. Herein, we demonstrate a novel effect of gefitinib which involves induction of macroautophagy (autophagy) in breast cancer cells. Using imaging-based High Content Analysis (HCA) techniques we show that in MFC7 cells stably transfected with autophagy marker MAP1LC3 tagged with GFP (LC3GFP) (MCF7-LC3GFP), gefitinib causes relocation of cytoplasmic LC3GFP protein to autophagosomes resulting in accumulation of LC3GFP-positive vesicles in a concentration and time dependent fashion. The HCA data also revealed that the induction of autophagosomes in gefitinib treated MCF7-LC3GFP cells was accompanied by the parallel increase in the number of cytoplasmic vesicles which stained positively with acidotropic lysotracker red and monodansylcadaverine ...
Also in human (MCF-7 and MDA-MD-231) mammary tumor cells lines, γ-tocotrienol induced apoptosis through induction of autophagy with evidences of the presence of relatively large increase in the accumulation of monodansylcadaverine (MDC)-labeled vacuoles, a marker of autophagosome formation(9). In neoplastic(gene modification) +SA(high malignance) mammary epithelial cells, treatment with 4 microM gamma-tocotrienol, a dose that inhibited +SA cell growth by more than 50% compared with that of untreated control cells, decreased intracellular levels of activated PI3K/Akt (anti-apoptosis and increased cell proliferation) pathway(10). On mouse (+SA) and human (MCF-7, and MDA-MB-231) mammary cancer cell lines, Combined γ-tocotrienol and SU11274 (Met inhibitor) treatment resulted in synergistic inhibition through reduction in Akt (multiple cellular processes) STAT1/5 (activator of transcription 1,5 )and NFκB(a transcription factor that has crucial roles in inflammation, immunity, cell proliferation ...
Biogenic amines (BAs) are organic amines present in meat, fish, dairy produce and wine due to the breakdown of amino acids, catalysed by microbial decarboxylases. BAs determination in food is important not only because of possible toxicological effects such as nausea, sweating and headache but also due to their possible role as indicators of food spoilage. Chromatographic methods are traditionally applied for determination of BAs in food [1], which usually require preliminary operations for sample pre-treatment that are laborious and difficult to automate. On the other hand, screening analytical systems provide simple, low cost and rapid analysis with the possibility of subjecting high number of samples to the screening system in a short time [2]. In this work we present a novel method for screening determination of BAs using a microfluidic system with the detection by highly sensitive thermal lens microscope (μFIA-TLM). Four biogenic amines (putrescine, cadaverine, histamine and tyramine) were ...
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TY - JOUR. T1 - Tissue transglutaminase and the progression of human renal scarring. AU - Johnson, Timothy S.. AU - El-Koraie, Ahmed F.. AU - Skill, N.. AU - Baddour, Nahed M.. AU - El Nahas, A. Meguid. AU - Njloma, Melvin. AU - Adam, Ahmed G.. AU - Griffin, Martin. PY - 2003/8/1. Y1 - 2003/8/1. N2 - Experimental renal scarring indicates that tissue transglutaminase (tTg) may be associated with the accumulation of extracellular matrix (ECM), both indirectly via TGF-β1 activation and directly by the formation of ε(γ-glutamyl) lysine dipeptide bonds within the ECM. The latter potentially accelerates deposition and confers the ECM with resistance to proteolytic digestion. Studied were 136 human renal biopsy samples from a range of chronic renal diseases (CRD) to determine changes in tTg and ε(γ-glutamyl) lysine crosslinking. Immunofluorescence for insoluble tTg showed a 14-fold increase in the kidneys of CRD patients (5.3 ± 0.5 versus 76 ± 54 mV/cm2), which was shown to be active by a ...
Buy our Transglutaminase 2 293T transfected lysate (positive control). ab94220 has been validated in western blot. Abcam now offers a 12-month guarantee.
I was diagnosed a couple weeks ago with Celiac so Im starting my journey with this new life . My test results were : IgA,Tissue Transglutaminase Ab, S ...
sp:TGM3_MOUSE] Tgm3, AI893889, TG_E, TG(E), TGE, TGase_E, TGase-3, we; transglutaminase 3, E polypeptide; K05620 transglutaminase 3 [EC:2.3.2.13] ...
sp:TGM3_MOUSE] Tgm3, AI893889, TG_E, TG(E), TGE, TGase_E, TGase-3, we; transglutaminase 3, E polypeptide; K05620 transglutaminase 3 [EC:2.3.2.13] ...
xtr:100145475 K05620 transglutaminase 3 [EC:2.3.2.13] , (RefSeq) tgm6; transglutaminase 6 (A) MRSDPQVIACDWYYAVNEKAHHTDVYESDDLVLRRGQPFKLTLMLNRPLQAEENILFIFE TGPSPSETSKTKVVFPLFRAENLQSWGAILTSIKSTSITVTINSHSDAVIGRYILSVAVQ CRGSDKPLPHQIGALNLLFNPWLQGDAVFMAEEDQRQEYVMNEQGVIFQGSDEDITSINW EYNQFERNILDICLVILDRSQNYKKDPALDVSQRNDPLYVCRVLSAMLNSKGDDGVLEEN WSDDYINGASPSSWNGSMNILKSWYYSKFKPVKYGQCWVYAGMLCTVLRSLGIPTRVITH FNSGQDKNANLFIDLQYKSQGSRQNDQEDQLWNFHVWNEAYFKRRDLGKSYNGWQVIDST PLKRSDGVYQCGPAPLTAIKEGDINLNYDVKYMFASVNADVACWIYYRNGTKKQVSNNAK ETGKFISTKAIGSNDRVDVTNNYKYAKGSEKEIKVFEKALKLSKGSFVGRTREKPRGGNI LFGRCTLDQIATFGQDFNLILSLKNLTPDSINVTVYINTSAILYTGRQRHTIWTGGKFLS LGPNLEKRFSIPVKYGQYSKHMTDNGVICMTALCEVEGTEERILVERNVSLVKPPLSITL PDKAIINQESNANIVIVNPLLETLNSCILWVEGYGLTDKILKKEVPSLKPGQSSEHNFVI TPMKTGVRTLLVNFSCDKIQNMKGSGKILITYSQEVSDSPVPT ...
In this study, the quantitative determination of eight biogenic amines (cadaverine, serotonin, histamine, spermidine, spermine, tyramine, putrescine and β-phenylethylamine) by an liquid chromatography method with evaporative light scattering detection was performed. The analysis of several samples of conventional, organic and fair trade cocoa-derivatives showed that organic and fair trade samples always contain much lower amine concentrations in comparison with their conventional counterparts, supporting the idea that biogenic amines can be regarded as cocoa quality markers. Irrespective of the kind of sample, results also showed that the most abundant amines were histamine, tyramine, spermidine, putrescine and spermine while β-phenylethylamine, cadaverine and serotonine have been found more rarely, all the amines never reaching dangerous amounts for consumer health. With the aim to confirm the experimental results, clustering analysis was performed on samples and instrumental results using principal
The microbial production of d-lysine has been of great interest as a medicinal raw material. Here, a two-step process for d-lysine production from l-lysine by the successive microbial racemization and asymmetric degradation with lysine racemase and decarboxylase was developed. The whole-cell activities of engineered Escherichia coli expressing racemases from the strains Proteus mirabilis (LYR) and Lactobacillus paracasei (AAR) were first investigated comparatively. When the strain BL21-LYR with higher racemization activity was employed, l-lysine was rapidly racemized to give dl-lysine, and the d-lysine yield was approximately 48% after 0.5 h. Next, l-lysine was selectively catabolized to generate cadaverine by lysine decarboxylase. The comparative analysis of the decarboxylation activities of resting whole cells, permeabilized cells, and crude enzyme revealed that the crude enzyme was the best biocatalyst for enantiopure d-lysine production. The reaction temperature, pH, metal ion additive, and
Agmatine, a divalent diamine with two positive charges at physiological pH, is transported into the matrix of liver mitochondria by an energy-dependent mechanism the driving force of which is ΔΨ (electrical membrane potential). Although this process showed strict electrophoretic behaviour, qualitatively similar to that of polyamines, agmatine is most probably transported by a specific uniporter. Shared transport with polyamines by means of their transporter is excluded, as divalent putrescine and cadaverine are ineffective in inhibiting agmatine uptake. Indeed, the use of the electroneutral transporter of basic amino acids can also be discarded as ornithine, arginine and lysine are completely ineffective at inducing the inhibition of agmatine uptake. The involvement of the monoamine transporter or the existence of a leak pathway are also unlikely. Flux-voltage analysis and the determination of activation enthalpy, which is dependent upon the valence of agmatine, are consistent with the ...
en] Soon after death, carcasses release volatile chemicals that attract carrion insects including Silphidae. Nevertheless, it is not known which chemical cues are involved in the attractiveness of the carcass. So far, little information is available on the chemical ecology of carrion beetles, particularly concerning the subfamily of Silphinae. The biological role of selected cadaveric volatile organic compounds including: dimethyldisulfide (DMDS), butan-1-ol, n-butanoic acid, indole, phenol, p-cresol, putrescine, and cadaverine on the silphine species, Thanatophilus sinuatus Fabricius, was investigated by using both electrophysiological and behavioural techniques. Among the tested cadaveric compounds, butan-1-ol and DMDS elicited the strongest EAG from both T. sinuatus male and female antennae. In a two-arm olfactometer, males and females were significantly attracted to dimethyldisulfide (DMDS) for both tested doses, whereas only males were attracted to p-cresol at 100 ng. Putrescine was ...
You are viewing an interactive 3D depiction of the molecule n-[4-({[(6r)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-d-glutamic acid (C20H26N7O6+) from the PQR.
D-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-,5-(9H-fluoren-9-ylmethyl)ester/ACM123417209 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Tissue transglutaminase (tTG) belongs to the family of transglutaminase enzymes that catalyze the posttranslational modification of proteins via Ca(2+)-dependent cross-linking reactions. The catalytic action of tTG results in the formation of an isopeptide bond that is of great physiological significance since it is highly resistant to proteolysis and denaturants. Although tTG-mediated cross-linking reactions have been implicated to play a role in diverse biological processes, the precise physiological function of the enzyme remains unclear. Recent data, however, suggest that the protein polymers resulting from tTG-catalyzed reactions may play a role in commitment of cells to undergo apoptosis. On the same token, tTG-mediated formation of insoluble protein aggregates may underlie the markers of numerous pathological conditions, such as the senile plaques in Alzheimers disease and the Lewy bodies in Parkinsons disease. In addition to catalyzing Ca(2+)-dependent cross-linking reactions, tTG can also
The present invention relates to use of a transglutaminase in the preparation of a medicament for inhibiting angiogenesis. Preferably, the transglutaminase is a human tissue transglutaminase. Advantageously, the medicament is for treating cancer, rheumatoid arthritis, retinopathy and/or psoriasis. Additionally, the invention relates to compositions comprising a transglutaminase in an amount sufficient to inhibit angiogenesis.
Required for Pcad induction, a promoter upstream of cadBA that is responsible for the pH-regulated expression of CadA and CadB. Probably acts as an activating transcription factor.
Transglutaminase 2/TGM2 Antibodies available through Novus Biologicals. Browse our Transglutaminase 2/TGM2 Antibody catalog backed by our Guarantee+.
Enzyme immunoassay for the detection of IgA antibodies to tissue transglutaminase (h-tTG) in human serum or plasma. SmartEIA kit is specifically designed for automated analysis using the Agility instrument.
1KV3: Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
PROBIND CH is a functional formulation based on the Transglutaminase enzyme which is specially designed to improve the texture and final yield in cheese...
TY - JOUR. T1 - Degradation of RNA in rat reticulocytes. I. Purification and properties of rat reticulocyte RNase. AU - Goto, Sataro. AU - Mizuno, DenIchi. PY - 1971/7. Y1 - 1971/7. N2 - A RNase has been partially purified from rat reticulocytes induced by phenylhydrazine. This enzyme has an optimum pH of 7.5 and degrades RNA endonucleolytically as evidenced by the analysis of degradation products. The activity is destroyed by heat treatment (pH 6.5, 80 °, 5 min). Many metal ions are inhibitory for the activity. The enzyme was inactivated almost completely by 0.5 mm HgCl2. Monovalent ions, including Nad, KCl, NH4Cl, and (NH4)2SO4, inhibit the enzyme by about 90% at concentrations of 0.1-0.2 m. The molecular weight of this enzyme is about 16,000 as determined by gel filtration. A latent RNase with higher molecular weight is present in the crude extract of the cells.. AB - A RNase has been partially purified from rat reticulocytes induced by phenylhydrazine. This enzyme has an optimum pH of 7.5 ...
It was the first morning without cockerels. The sun fell into the kitchen and hit the geraniums above the sink. Their petals were almost dead, but Tasha had kept them. They brightened up the yellow walls. According to her mother, who had been in charge of buying the paint, the colour was meant to create warmth. Instead, it reminded Tasha of her Aunt Aminas jaundice. She watched the dust drift into the pantry. It fell over the beetroot and settled on the skin of four, roughly plucked roosters. Their thin bodies might make a stew. She would tell Seb that a dog had eaten them. Tasha covered them with a newspaper and skimmed over the headlines. Nothing jumped out at her. Her mother refused to read them, refused even the radio. She smoked her pipe, trimmed the window boxes and spoke to her husband. He never had much to say on the matter.. A beetle clicked by the sink and Tasha watched it clamber into a bowl of grapes. It sat heavily within the bunch. She looked at her watch; Seb would be up soon. ...
TY - JOUR. T1 - Autoregulation of SafA assembly through recruitment of a protein cross-linking enzyme. AU - Fernandes, Catarina G.. AU - Moran, Charles P.. AU - Henriques, Adriano O.. PY - 2018/7/1. Y1 - 2018/7/1. N2 - The coat of Bacillus subtilis spores is a multiprotein protective structure that also arbitrates many of the environmental interactions of the spore. The coat assembles around the cortex peptidoglycan layer and is differentiated into an inner and an outer layer and a crust. SafA governs assembly of the inner coat, whereas CotE drives outer coat assembly. SafA localizes to the cortex-coat interface. Both SafA and its short form C30 are substrates for Tgl, a coat-associated transglutaminase that cross-links proteins through ε-(γ-glutamyl)lysyl isopeptide bonds. We show that SafA and C30 are distributed between the coat and cortex layers. The deletion of tgl increases the extractability of SafA, mainly from the cortex. Tgl itself is mostly located in the inner coat and cortex. The ...
Twenty Apulian and Sicilian cheeses were analysed for their concentrations of eight biogenic amines (BAs), free amino acids, pH, water activity, and subjected to microbiological characterisation. In addition, lactic acid bacteria isolated from cheeses were assayed for their capacity to generate BAs. Principal component analysis was performed to find the effect of different parameters on the distribution of the cheeses. Although short-ripened (<= 30 d) cheeses did not show significant BA concentrations, the only BA showing high positive correlation with time of ripening was histamine. Concentration of histidine and, especially, percentage of histidine-decarboxylase bacteria presumably affected histamine concentration. High pH values were negatively correlated to the concentration of tyramine, putrescine, and cadaverine. Fifty percent of the cheeses contained at least one BA at potentially toxic concentrations. Unambiguous and ever-valid relations among parameters and BAs are difficult to ...
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Bacterial transglutaminases are increasingly required as industrial reagents for in vitro modification of proteins in different fields such as in food processing as well as for enzymatic site-specific covalent conjugation of therapeutic proteins to polyethylene glycol to get derivatives with improved clinical performances. In this work we studied the production in Escherichia coli of a recombinant transglutaminase from Streptomyces mobaraensis (microbial transglutaminase or MTGase) as enzymatically active chimeric forms using different expression systems under the control of both lac promoter or thermoinducible phage lambda promoter. Thermoinducible and constitutive expression vectors were constructed expressing Met-MTGase with chimeric LacZ1-8PNP1-20 or LacZ1-8 fusion protein under different promoters. After transformed in competent Escherichia coli K12 strains were fermented in batch and fed-bach mode in different mediums in order to select the best conditions of expression. The two most performing
BioAssay record AID 752868 submitted by ChEMBL: Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis.
For BJH Laboratory Use Only. Analyte Stability:. See Analyte Stability Chart. Laboratory Processing Instructions:. Test performed in BJH Core Lab. Processed by automated line and aliquot stored refrigerated for batch analysis. Completed specimens are stored refrigerated for 5 days.. ...
1KV3: Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
The present invention provides compounds of the formula: |chemistry-cwu id=CHEM-US-00001 st32-name=CHEM-US|1|image id=EMI-C00001 he=74.9007 wi=85.4469 file=US20040167191A1-20040826-C00001
A transglutaminase é uma enzima que actua como catalisadora de reacções de ligações entre moléculas de proteína. Este tipo de ligações resultantes da acção desta enzima, são de grande estabilidade e ocorrem entre os aminoácidos glutamina e lisina. Sendo assim,...
Transglutaminase 2兔多克隆抗体(ab71099)可与人样本反应并经WB, IHC, ICC/IF实验严格验证。所有产品均提供质保服务,中国75%以上现货。
Halal is an Arabic word means lawful or permitted. It is always mentioned along with Haraam which means sinful or prohibited by Allah. At the same time, you wil…
TY - JOUR. T1 - Human recombinant tissue transglutaminase ELISA. T2 - An innovative diagnostic assay for celiac disease. AU - Sblattero, D.. AU - Berti, I.. AU - Trevisiol, C.. AU - Marzari, R.. AU - Tommasini, A.. AU - Bradbury, A.. AU - Fasano, A.. AU - Ventura, A.. AU - Not, T.. PY - 2000/5. Y1 - 2000/5. N2 - OBJECTIVE: Tissue transglutaminase is the autoantigen recognized by the sera of celiac patients. An enzyme-linked immunosorbent assay (ELISA) based on guinea-pig tissue transglutaminase was recently used to measure serum tissue transglutaminase antibodies for the diagnosis of celiac disease. We determine the sensitivity and specificity of an ELISA test based on the use of human recombinant transglutaminase, compared with the guinea pig transglutaminase ELISA and IgA antiendomysium antibodies. METHODS: Serum samples were tested from 65 patients with intestinal biopsy proven celiac disease, from 10 patients with Crohns disease, and from 150 healthy blood donors. RESULTS: Human ...
Endostatin, a C-terminal fragment of collagen XVIII, binds to TG-2 (transglutaminase-2) in a cation-dependent manner. Recombinant human endostatin binds to TG-2 with an affinity in the nanomolar range (Kd=6.8 nM). Enzymatic assays indicated that, in contrast with other extracellular matrix proteins, endostatin is not a glutaminyl substrate of TG-2 and is not cross-linked to itself by the enzyme. Two arginine residues of endostatin, Arg27 and Arg139, are crucial for its binding to TG-2. They are also involved in the binding to heparin [Sasaki, Larsson, Kreuger, Salmivirta, Claesson-Welsh, Lindahl, Hohenester and Timpl (1999) EMBO J. 18, 6240-6248], and to α5β1 and αvβ3 integrins [Faye, Moreau, Chautard, Jetne, Fukai, Ruggiero, Humphries, Olsen and Ricard-Blum (2009) J. Biol. Chem. 284, 22029-22040], suggesting that endostatin is not able to interact simultaneously with TG-2 and heparan sulfate, or with TG-2 and integrins. Inhibition experiments support the hypothesis that the GTP-binding site ...
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Factor XIIIa小鼠单克隆抗体[AC-1A1](ab1834)可与小鼠, 人样本反应并经WB, ELISA, IHC, Flow Cyt, ICC/IF实验严格验证,被5篇文献引用。所有产品均提供质保服务,中国75%以上现货。
baci:B1NLA3E_09130 K00686 protein-glutamine gamma-glutamyltransferase [EC:2.3.2.13] , (GenBank) tgl; transglutaminase (A) MIQLSGIPFQQSGMWPPGYIESVIILKMHEAPAVYSYQSMDELLFELKLRKKIIESARSM SRGHARFASFAKSRCNPRFWHLTNTGGFWLRYDVKPSDAIRDIYKNSSLYAFECATAKVI IYYDAILNSIDEHLFNQLFQNLYLYSWHFDPDFGIHSFYSDHLIPGDVAYFNNPDFNPKT PWWKGENAVVLGDGKYFGHGLGIRNAEQMIQALNKRRKPGSNQSAYLTNIVTSLSFKQLT NFLMLQQRFSDYKIKHAVIHHNESSISFARYLFYLNKVNNRIT ...
Uh-oh," said Linnsy, as my mother dropped us off in front of school on Monday morning. "Looks like things have gotten weird again.". Linnsy is my upstairs neighbor. Shes screamingly normal herself, so she can spot weird from a mile away.. You didnt have to be normal (something I, personally, have never managed to achieve) to realize something was cooking at the school. The sight of eight black limousines-not to mention all the sunglasses-wearing men and women dressed in black-was a pretty good clue.. Our school has been very security conscious ever since the first alien ambassador to Earth decided he was going to send his kid here. Even so, we hadnt seen this many agents since the day Pleskit arrived.. I wondered if we were having a new infestation of reporters. Mom and I had already gotten several calls at home from newspapers and TV news magazines wanting to know what had happened at school the previous week. We hadnt talked to them, of course. I figured probably someone would, but I ...
Autophagy plays a critical role in cancer formation and therapeutic resistance. However, little is known about how autophagy is regulated in cancer and how it mediates therapeutic resistance. Here we elect to use chronic myeloid leukemia (CML) as a cancer model to study autophagy in that it is driven by a single onco-protein BCR-ABL, whose activity can be selectively blocked by imatinib a front-line treatment for CML. Moreover, imatinib resistance frequently occurs in CML patients. Thus, unraveling autophagy regulation in CML and its role in overcoming imatinib resistance has substantial therapeutic benefits not only for CML but also for other cancers that can be treated by imatinib. In this report, we performed a genome-wide RNA interference screen in K562 human CML cells using monodansylcadaverine (MDC) that marks autolysosomes followed by fluorescence-activated cell sorting to label and isolate autophagic cells. We have identified 336 candidate genes, knockdown of which significantly ...
The present study aims to investigate the mechanism of miR-384 in non-small cell lung cancer (NSCLC) cell apoptosis and autophagy by regulating Collagen α-1(X) chain (COL10A1). Bioinformatics methods were applied to evaluate potential miRNAs and genes that might correlate with NSCLC. Tumor tissues and adjacent tissues from 104 NSCLC patients were collected and human NSCLC A549 cell line was selected for subsequent experiments. A549 cells were treated with miR-384 mimic, miR-384 inhibitor, or knockdown of COL10A1. Quantitative real-time PCR (qRT-PCR) and Western blotting were utilized to detect the levels of miR-384, COL10A, Survivin, Bcl-2, Bax, Bcl-xl, Beclin 1, and LC3 in tissues and cells. A series of biological assays including MTT assay, Annexin V-FITC/PI (propidium iodide) staining, immunofluorescence, monodansylcadaverine (MDC) staining were conducted to investigate the effects of miR-384 and COL10A1 on NSCLC cells. Tumorigenicity assay for nude rats was applied. Results obtained from ...
The simultaneous determination of 17 free amino acids and 8 biogenic amines in Alicante Monastrell wines was investigated for the first time. The quantification was carried out by using a RP-HPLC method. based on a pre-column derivatization with o-phthaldialdehyde (OPA) and fluorescence detection. From the results obtained it may be concluded that the most abundant free amino acids were Glu, Arg, Ala Asp, and Lys. None of the wine samples analysed had histamine (HIM) or Tyramine (TYM) levels above the limits considered as a possible toxic risk for healthy individuals. No measurable amounts of cadaverine (CAD) or methylamine (MEA) were found, showing no spoilage symptoms of sensory properties of the wines. Tryptamine (TRM) content was significantly higher in aged wines compared to young wines. However ethanolamine (ETA) content was lower. These data were used to make a preliminary classification of the samples using cluster analysis. (C) 2012 Elsevier Ltd. All rights reserved ...
0047] In some alternate embodiments, the polyamine may be N-Methylethylenediamine, Propylenediamine, 1,4-Diaminobutane, 3-(Methylamino)propylamine, N,N-Dimethylethylenediamine, N-Ethylethylenediamine, Diethylenetriamine, 1-Dimethylamino-2-propylamine, 3-(Dimethylamino)-1-propylamine, Cadaverine, N,N,N-Trimethylethylenediamine, N-Isopropylethylenediamine, N-Propylethylenediamine, 2-(Aminomethyl)-2-methyl-1,3-propanediamine, N-(2-Aminoethyl)-1,3-propanediamine, Bis(dimethylamino)methylsilane, 2,6-Dichloro-p-phenylenediamine, 4,5-Dichloro-o-phenylenediamine, 4-Bromo-1,2-diaminobenzene, 4-Chloro-1,3-diaminobenzene, 4-Chloro-o-phenylenediamine, 4-Fluoro-1,2-phenylenediamine, 4-Fluoro-1,3-diaminobenzene, 2-Nitro-1,4-phenylenediamine, 3-Nitro-1,2-phenylenediamine, 4-Nitro-o-phenylenediamine, 1,2-Phenylenediamine, 1,3-Phenylenediamine, m-Phenylenediamine, o-Phenylenediamine, p-Phenylenediamine, Hexamethylenetetramine, (±)-trans-1,2-Diaminocyclohexane, 1,2-Diaminocyclohexane, ...
A transglutaminase is an enzyme that catalyzes the formation of an isopeptide bond between a free amine group (e.g., protein- or peptide-bound lysine) and the acyl group at the end of the side chain of protein- or peptide-bound glutamine. The reaction also produces a molecule of ammonia. Such an enzyme is classified as EC 2.3.2.13. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). Transglutaminases were first described in 1959. The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968. Eight transglutaminases have been characterised. Transglutaminases form extensively cross-linked, generally insoluble protein polymers. These biological polymers are indispensable for an organism to create barriers and stable structures. Examples are blood clots (coagulation factor XIII), as well as skin and hair. The catalytic reaction is generally viewed as being irreversible, and must be closely monitored ...
Osteopontin (OPN) is a highly posttranslationally modified protein present in several tissues where it is implicated in numerous physiological processes. OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Ser-Val-Val-Tyr-Gly-Leu-Arg sequences located in the N-terminal part of the protein. OPN can be polymerized by the cross-linking enzyme transglutaminase 2 (TG2), and polymerization has been shown to enhance the biological activity of OPN. However, little is known about the reactivity and location of the glutamine and lysine residues involved in the TG2-mediated modification of OPN. Here we show that TG2 catalyses the incorporation of 5-(Biotinamido)pentylamine at glutamines in both the N- and C-terminal parts of OPN, whereas TG2 primarily incorporated the glutamine-donor peptide biotinyl-TVQQEL-OH into the C-terminal part of OPN. By mass spectrometric analyses we identified Gln34, Gln42, Gln193 and Gln248 as the major TG2 reactive glutamines in OPN. The
A 2009 issue of The Journal of Immunology (Novel Role of Tissue Transglutaminase (TG2) in Chronic Inflammatory Diseases) had something to say about this. Transglutaminases are enzymes that allow us to break down wheat protein, otherwise known as Gluten. In people with Celiac Disease (not to mention numerous people who do not have Celiac Disease --- HERE), the body makes anti-Transglutaminase antibodies. In other words, not only is the body attacking Gluten as though it were a foreign invader (HERE), its attacking the enzyme that helps break down Gluten as well. The study mentioned at the top of the page revealed that, "Tissue transglutaminase (TG2) has a critical role in the pathogenesis of chronic inflammatory diseases." Not that I have time to get into it today, but Gluten is arguably the single biggest factor in developing AUTOIMMUNE DISEASES (HERE is a list of A.I. diseases). And how about this for a "fun fact"? The "Modern Pantry" website sells Transglutaminase for kitchen use. Listen to ...
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TY - JOUR. T1 - Large plasmids in ruminal strains of Selenomonas ruminantium. AU - Fliegerova, K AU - Benada, O AU - Flint, H J PY - 1998/4. Y1 - 1998/4. N2 - The plasmid content of six different isolates of Selenomonas ruminantium from the rumen of sheep, cows or goats was examined by electron microscopy. In addition to small plasmids (, 12 kb) studied previously, all six strains contained at least one plasmid larger than 20 kb. Plasmid sizes of 1.4, 2.1, 2.4, 5.0, 6.2, 20.4, 20.8, 22.7, 33.3, 29.3, 30.7, 34.4 and 42.6 kb were estimated from contour length measurements. DNA-DNA hybridization experiments revealed homology among the large plasmids from five strains, while the 20.8 kb plasmid from a sixth isolate showed no apparent relationship with the plasmids of the other strains.. AB - The plasmid content of six different isolates of Selenomonas ruminantium from the rumen of sheep, cows or goats was examined by electron microscopy. In addition to small plasmids (, 12 kb) studied previously, ...
TY - JOUR. T1 - The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase role of aldehyde metabolites. AU - Szabo, Csaba. AU - Southan, G. J.. AU - Thiemermann, C.. AU - Vane, J. R.. PY - 1994. Y1 - 1994. N2 - 1. We have recently found that in the presence, but not in the absence, of foetal calf serum, spermine inhibits the production of nitric oxide (NO) in cultured J774.2 macrophages stimulated with bacterial endotoxin (lipopolysaccharide, LPS) or with γ-interferon (IFN), showing that polyamines may act as suppressants of NO-mediated immune functions. Here, we have studied the mechanisms and the specificity of this inhibitory action. 2. Other polyamines, as well as spermine, inhibit the formation of NO in cultured J774.2 macrophages, with the order of potency being spermine , spermidine ,, putrescine = cadaverine. This inhibition of NO formation is not due to any cytotoxic effect of these agents for they neither reduced mitochondrial respiration nor ...
Abstract A method for the determination of histamine, 2-phenylethylamine, tryptamine, putrescine, cadaverine, spermidine and spermine in fish using micellar electrokinetic capillary chromatography (MECC) was developed. Seven biogenic amines (BAs) were extracted from a sample with 6% perchloric acid, then derivatized with benzoyl chloride. 0.02 mol/L borate buffer (pH 9.2) containing 0.06 mol/L sodium deoxycholate-methanol (95∶5, v/v)was used as a running buffer. The detection wavelength was set at 214 nm. The separation was achieved within 12 min. Good linearities were observed from the calibration plots in the concentration ranges. The detection limit of histamine was 15 μg/g and those of the other amines were 5 μg/g. The developed method was successfully employed for the simultaneous determination of 7 BAs in fish sample with satisfactory results. ...
Factor XIIIa is a blood coagulation prototransglutaminase1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca2+. FXIIIa plays a key role in fibrin stabilisation and defective fibrin stabilisation is demonstrable as a result of severe haemorrhagic manifestations of congenital FXIII deficiency, which is an autosomal recessive disorder. In the plasma form, the enzyme is a heterotetramer composed of paired A and B subunits (A2B2). In the tissue or cellular form, the protein lacks the B subunits and is therefore structurally a homodimer of A subunits (A2). Genetic studies have mapped the gene coding for the A and B subunits to chromosomes 6p24-25 and 1q31-32.1 respectively. Studies on placental tissue using cDNA coding for human factor XIIIa revealed isolated factor XIIIa cDNA size to be composed of 3905 bases, which code for a protein composed of 732 amino acids.2 Cells of the bone marrow origin are believed to be the ...
13Diaminopropane also known as trimethylenediamine is a simple diamine with the formula CH23NH22 A colourless liquid with a fishy odor it is soluble
Buy our Natural Human Factor XIIIa protein. Ab62412 is a full length protein produced in Nativesyntheticaly and has been validated in SDS-PAGE. Abcam provides…
Gamma Glutamyltransferase, 0.1 mg. Tissue transglutaminase is a calcium activated enzyme which catalyzes the cross linking of proteins and the conjugation of polyamines to proteins.
thieno(2,3-d)pyrimidin-4-one acylhydrazide: moderately potent inhibitor of TGase 2 (tissue transglutaminase); structure in first source
Cyclic Diamines - A wide range of aliphatic and aromatic diamines; indole, indoline, piperidine and piperazine derivatives with diamine function.
This assay is designed for the in-vitro measurement of specific IgG autoantibodies against tissue transglutaminase (tTG) present in human serum, as an...
Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, Schilling S. Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics ...
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Rabbit anti tissue transglutaminase antibody recognizes tissue transglutaminase, also known as protein-glutamine gamma-glutamyltransferase
Human type II transglutaminase (TG2) is an enzyme that exists in two dramatically different conformational states, each with a unique activity. In the open, extended form, the transglutaminase active site is exposed, allowing TG2 to catalyze formation of an isopeptide bond between the sidechain of a peptide-bound glutamine and a primary amine. Upon GTP binding to a separate GTPase active site, TG2 adopts a heavily favored and compact closed conformation, which obstructs the glutaminase active site, and only allows GTPase activity. TG2 has been linked to Huntingtons disease, as well as to many other cellular processes, both physiological and pathological. However, TG2s two conformational states, each with its own activity, have made it difficult to elucidate how this enzyme functions in disease progression. In addition, because TG2 heavily prefers the closed state, attempts to screen for inhibitors that may bind the transglutanimase site exposed in the open conformation, and attempts to obtain ...
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2005 (English)In: Journal of Clinical Gastroenterology, ISSN 0192-0790, E-ISSN 1539-2031, Vol. 39, no 1, 80-81 p.80-81 p.Article in journal (Refereed) Published ...
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Qpct - Qpct (untagged) - Mouse glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct), (10ug) available for purchase from OriGene - Your Gene Company.
The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metallopr
The so-called "meat glue enzyme" transglutaminase is used by the meat industry to add value to meat by gluing together smaller scraps into a larger chunk. And its not just used to make fake steak--the American Meat Institute estimates....... ...
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Carrion (from Latin caro, meaning "meat") is the decaying flesh of a dead animal. Carrion is an important food source for large carnivores and omnivores in most ecosystems. Examples of carrion-eaters (or scavengers) include vultures, hawks, eagles, hyenas, Virginia opossum, Tasmanian devils, coyotes, and Komodo dragons. Many invertebrates such as the carrion and burying beetles, as well as maggots of calliphorid flies and flesh-flies also eat carrion, playing an important role in recycling nitrogen and carbon in animal remains. Play media Carrion begins to decay the moment of the animals death, and it will increasingly attract insects and breed bacteria. Not long after the animal has died, its body will begin to exude a foul odor caused by the presence of bacteria and the emission of cadaverine and putrescine. Some plants and fungi smell like decomposing carrion and attract insects that aid in reproduction. Plants that exhibit this behavior are known as carrion flowers. Stinkhorn mushrooms are ...
Zn(II)-dependent glutaminyl cyclase (QC) converts N-terminal glutamine or glutamate residues of peptides and proteins. The reaction product is in both cases N-terminal pyroglutamic acid (pyroGlu). In animals the glutaminyl cyclization is involved in posttranslational modification and activation of peptide-based hormone and chemokine precursors. Recently it was established that the driving force in neurodegenerative processes is the pyroGlu modification at the N-terminus of Aβ peptides processed by QC. This unveils the inhibition of QC as a strategy in AD treatment. The enzyme-specific inhibition is required in order to avoid noxious side effects. The elucidation of the reaction mechanism might make possible the development of mechanism-based QC inhibitors (e.g. transition-state analog compounds). Mechanistic and structural investigations were accomplished using the mitochondrial isoform of QC from Drosophila melanogaster. Regarding enzyme kinetic and structural properties, this enzyme is highly ...
Freeze-substitution and Lowicryl HM20 embedding of fixed rat brain: suitability for immunogold ultrastructural localization of buy generic viagra neural antigens. The unique cellular enzymatic machinery of halophilic microbes allows them to thrive in extreme saline environments. Involucrin, a cornified envelope precursor, and the cross-linking enzyme transglutaminase, were increased at both the message level (2-7-fold) and the protein level (4-12-fold) by clofibric acid.. Deep cannulation of parent catheters was accomplished in all buy viagra three cases and complications such as vascular injury were not observed in the postprocedure angiograms. The experimental values used to determine this law were obtained for both parameters using only field measurements methods.. The 2008 CDC criteria did not predict outcomes, whereas VAE only identified very severe events. Immunohistochemical and serological characterization of membranous nephropathy in children and buy viagra online adolescents. Improving ...
Transitions in amino-acid conformation angles tend to accompany various structural modifications in protein structures. Thus, to benefit the modeling of protein structures, the Conformation Angles DataBase (CADB-3.0) has been updated to visualize the conformational angles in varied regions (fully, generously, additionally and disallowed regions). In addition, options are provided to display the angles in the secondary structural elements (α-helix, β-sheet and 310-helix) of the Ramachandran plot. The database is being updated periodically and can be accessed over the World Wide Web at the following URL: http://cluster.physics.iisc.ernet.in/cadb ...
Transglutaminase-2 antibody [Biotin] | P21980 | Tissue transglutaminase (TG2), Transglutaminase C (TG(C)), (TGC), (TGase C), Transglutaminase H (TGase H), Transglutaminase-2 (TGase-2)
Using immunogold-silver techniques, we have demonstrated that, in rats, type-I (keratinocyte) transglutaminase is expressed primarily in stratified squamous epithelia of the integument, the upper digestive tract, and the lower female genital tract. PMID: 2436965 ...
Transglutaminase-2 antibody | | Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase (TG2), Transglutaminase C (TG(C), TGC, TGase C), Protein-glutamine gamma-glutamyltransferase 2
TY - JOUR. T1 - Determination of histamine content in vegetable juices by using direct and competitive immunosensors. AU - Adányi, Nóra. AU - Székács, Inna. AU - Szendro, István. AU - Székács, András. PY - 2014/1/1. Y1 - 2014/1/1. N2 - An Optical Waveguide Lightmode Spectroscopy (OWLS)-based immunosensor was developed for selective and sensitive determination of histamine content in fermented vegetable juices. The conjugate of the antigen (histamine-bovine serum albumin 10 μg mL-1) was attached on the amino modified sensor surface with glutaraldehyde. During the measurement standard solutions or samples were mixed with antibodies of appropriate concentration (1:1000), the mixture was incubated for 1 minute and injected into the OWLS system. The amount of antibodies bound to immobilised antigen conjugates was inversely proportional to the histamine content. Relative substrate specificity of the antibody was studied, and besides histamine, only putrescine, cadaverine and agmatine were ...
Primary examples are putrescine, cadaverine, spermidine, and spermine. In animals, their levels are maintained from both the ... Cadaverine is synthesized from lysine in a one-step reaction with lysine decarboxylase (LDC). Spermidine is synthesized from ...
Interview with Sarah Rayner, Cadaverine Magazine, 22 February 2010. One Moment, One Morning, Publishers Weekly, 10/17/2011 ...
... is an enzyme that converts lysine to cadaverine. Gale EF, Epps HM (1944). "Studies on bacterial amino-acid ...
Tracer studies using 13C-15N-doubly labeled cadaverine have shown three units of cadaverine are incorporated into sparteine and ... The deaminated cadaverine is not released from the enzyme, thus is can be assumed that the enzyme catalyzes the formation of ... The first intermediate in the biosynthesis is cadaverine, the decarboxylation product of lysine catalyzed by the enzyme lysine ... Enzymatic evidence then showed that the three molecules of cadaverine are transformed to the quinolizidine ring via enzyme ...
Although scientists asserted that cadaverine was also extracted by heating coal, the public often refused to listen. A woman ... 1,5-pentanediamine (cadaverine) (PMD): starch (e.g. cassava) → glucose → lysine → PMD.[57] ... Actually the most common nylon polymers are made from hexamethylenediamine, with one more CH2 group than cadaverine. ... suggested that one method of producing nylon might be to use cadaverine (pentamethylenediamine),[a] a chemical extracted from ...
Several residues are necessary for recognition of cadaverine in the periplasm because the level of cadaverine is much lower ... "Identification of the cadaverine recognition site on the cadaverine-lysine antiporter CadB". The Journal of Biological ... In addition, Trp(43), Tyr(57), Tyr(107), Tyr(366), and Tyr(368) of CadB are involved preferentially in cadaverine uptake at ... The structure and function of the cadaverine-lysine antiporter, CadB (2.A.3.2.2), and the putrescine-ornithine antiporter, PotE ...
"Effect of cadaverine and lysine on the urinary excretion of piperidine in rabbits". Acta pharmacologica et toxicologica. 7 (3 ...
... and cadaverine were first described in 1885 by the Berlin physician Ludwig Brieger (1849-1919). Putrescine is ... and cadaverine (literally meaning "the essence of dead cadavers"). Yeoman, CJ;Thomas, SM; Miller, ME; Ulanov, AV; Torralba, M; ... putrescine and cadaverine in rats". Food and Chemical Toxicology. 35 (3-4): 337-348. doi:10.1016/S0278-6915(97)00121-X. ISSN ... that is related to cadaverine; both are produced by the breakdown of amino acids in living and dead organisms and both are ...
The substances cadaverine and putrescine are produced during the decomposition of animal (including human) bodies, and both ... a larger dose for cadaverine); there are no effects at all for a tenth of that dose. While figures for humans are not available ... putrescine and cadaverine in rats". Food and Chemical Toxicology. 35 (3-4): 337-348. doi:10.1016/S0278-6915(97)00121-X. ISSN ...
Cadaverine Microbiology of decomposition Putrescine Staling Humus Leachate Peat (turf) Water Quality Vocabulary. IShaO 6107-6: ... These processes release compounds such as cadaverine and putrescine, that are the chief source of the unmistakably putrid odor ...
This cell can also use L-lysine, nitrate and cadaverine as sole nitrogen sources. This species cannot ferment. C. albidosimilis ...
Cadaverine, a foul-smelling chemical released during decomposition. *Conservation and restoration of human remains ...
... putrescine and cadaverine. The 1892 Merck's Bulletin stated, "We name such products of bacterial origin ptomaines; and the ... special alkaloid produced by the comma bacillus is variously named Cadaverine, Putrescine, etc." While The Lancet stated, "The ...
This species is also able to assimilate L-lysine, nitrate and cadaverine as nitrogen sources. Vishniac H. S., Kurtzman C. P. ( ...
... can also be compounded as a vinyl sulfone, with ethylenediamine, or with cadaverine. [clarification needed] ...
Review by Annabella Massey, Cadaverine Magazine Works by or about Peter Bush in libraries (WorldCat catalog). ...
Basic amines such as putrescine, spermine, spermidine and cadaverine are responsible for the smell and flavor of semen. These ...
The disulphides than binds to DNA and precipitate nucleoproteins have an analogous interaction like cadaverine and spermidine ...
The molecular formula C5H14N2 (molar mass : 102.17 g/mol) may refer to: Cadaverine Dimethylaminopropylamine N,N′-Dimethyl-1,3- ...
Stage 2: Putrefaction - Bacteria grow throughout the body, releasing gases, including cadaverine, which in turn bloat the body ...
Cadaverine Cadaverine. *Caiféin Caffeine. *CailciféarólCalciferol (Vitamin D). *calcitonin. *Calmodulin. *Calmodulin. * ...
... cadaverine, or spermidine) to the SpeF leader. Other non-coding RNAs uncovered in the same analysis include: suhB, ybhL, metA ...
... its body will begin to exude a foul odor caused by the presence of bacteria and the emission of cadaverine and putrescine. Some ...
... is able to use nitrate, nitrite and cadaverine, a protein created when animals decay which produces the ...
Cadaverine is one of the biogenic amines that some LAB species, particularly from the Lactobacillus and Pediococcus genera, ... In wine, histamine, cadaverine, phenylethylamine, putrescine, and tyramine have all been detected. These amines are created by ...
... a black precipitate Two common decarboxylation products of protein associated with decomposition are putrescine and cadaverine ...
... is a alkane-α,ω-diamine (CHEBI:35411) cadaverine (CHEBI:18127) is conjugate base of cadaverine(2+) ( ... cadaverine (CHEBI:18127). monodansylcadaverine (CHEBI:52007) has functional parent cadaverine (CHEBI:18127). cadaverine(2+) ( ... cadaverine (CHEBI:18127) has role Daphnia magna metabolite (CHEBI:83056) cadaverine (CHEBI:18127) has role Escherichia coli ... cadaverine (CHEBI:18127) has role mouse metabolite (CHEBI:75771) cadaverine (CHEBI:18127) has role plant metabolite (CHEBI: ...
... called cadaverine, are foul-smelling compounds found in decaying flesh. Amines are colourless; aliphatic amines are transparent ... and H2N(CH2)5NH2, called cadaverine, are foul-smelling compounds found in decaying flesh. Amines are colourless; aliphatic ...
Cadaverine is a toxic diamine with the formula NH2(CH2)5NH2, which is similar to putrescine. Cadaverine is also known by the ... Putrescine and cadaverine were first described in 1885 by the Berlin physician Ludwig Brieger (1849-1919). Cadaverine is the ... Pentolinium and pentamethonium are both chemical derivatives of cadaverine. Cadaverine is toxic in large doses. In rats it has ... Elevated levels of cadaverine have been found in the urine of some patients with defects in lysine metabolism. The odor ...
Alexa Fluor 594 Cadaverine is useful as a polar tracer and as a reactive dye for labeling proteins via a carboxylic acid moiety ... Alexa Fluor® 594 Cadaverine is useful as a polar tracer and as a reactive dye for labeling proteins via a carboxylic acid ... Alexa Fluor® cadaverines can be used as reactive molecules for adding a fluorescent label to carboxylic acids using a coupling ... Alexa Fluor® cadaverines make excellent fluorescent polar tracers because they are bright, small, and water soluble. Since they ...
Previous research suggests cadaverine has a role in stress response, with groups reporting an increase in content upon exposure ... Previous research suggests cadaverine has a role in stress response, with groups reporting an increase in content upon exposure ... Cadaverine is also present in the environment; it can be produced by rhizosphere and phyllosphere microbes. Markedly, exogenous ... Cadaverine is also present in the environment; it can be produced by rhizosphere and phyllosphere microbes. Markedly, exogenous ...
Recombinant XBHaLDC produced a 1.3-fold higher titer of cadaverine (6.1 g/L) than the XBEcLDC strain (4.8 g/L) from 10 g/L of l ... Cadaverine is produced by the decarboxylation of l-lysine using a lysine decarboxylase (LDC). In this study, we developed ... Cadaverine synthesized via a whole cell biocatalyst reaction using XBHaLDC was purified to polymer grade, and purified ... Furthermore, XBHaLDC, concentrated to an optical density (OD600) of 50, efficiently produced 136 g/L of cadaverine from 200 g/L ...
4-Sulforhodamine 101 Cadaverine, Trifluoroacetate Salt 4-Sulforhodamine 101 cadaverine can be coupled to activated carboxy ... 4-Sulforhodamine 101 cadaverine can be coupled to activated carboxy groups or sulfonyl chlorides. ...
Endogenous spermine levels modulate their expression and determine the sensitivity to cadaverine. Arabidopsis sp ... Arabidopsis Cadaverine response L-Amino acid Transporter 1 Organic Cation Transporter 1 Polyamine Spermine ... Kuznetsov V, Shorina M, Aronova E, Stetsenko L, Rakitin V, Shevyakova N (2007) NaCl- and ethylene-dependent cadaverine ... Spermine modulates the expression of two probable polyamine transporter genes and determines growth responses to cadaverine in ...
Cadaverine and putrescine in semen I just found out that my semen has cadaverine and putrescine . Cadaverine is a foul-smelling ... Dont know about putrescine, but cadaverine is a natural ingredient of the semen. Its not a problem. If You want to taste like ...
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... it was assumed to be created from cadaverine by intestinal bacteria.[2] No formation of piperidine from cadaverine was detected ... Cadaverine is a diamine that occurs as an endogenous amine in humans. Its the decarboxylation product of the essential amino ... 2. Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse. ... In vitro tests using mice found that piperidine formed from cadaverine in the large intestine; ...
Production of carbon-13-labeled cadaverine by engineered Corynebacterium glutamicum using carbon-13-labeled methanol as co- ... Production of carbon-13-labeled cadaverine by engineered Corynebacterium glutamicum using carbon-13-labeled methanol as co- ... Production of carbon-13-labeled cadaverine by engineered Corynebacterium glutamicum using carbon-13-labeled methanol as co- ... L. Leßmeier, et al., "Production of carbon-13-labeled cadaverine by engineered Corynebacterium glutamicum using carbon-13- ...
Be the first to review "Cadaverine 1%" Cancel reply. Your email address will not be published. Required fields are marked * ... From the name you might expect Cadaverine to smell like a rotting corpse and while there is certainly an element of that, most ... Solvent: MMB (with 10% ethanol and 0.1% BHT) to form a 0.1% solution of Cadaverine ...
... cadaverine dihydrochloride chemical synthesis methods, cadaverine dihydrochloride synthetic routes ect. ... cadaverine dihydrochloride 1476-39-7 Synthesis RouteTotal: 4 Synthesis Route 65898-76-2. ~97%. 107-46-0. 1476-39-7. View Detail ...
Cadaverine is a biogenic amine that can be produced by Corynebacterium glutamicum from the amino acid lysine by heterologous ... the patA and patD genes from Escherichia coli in Corynebacterium glutamicum enables the latter to further metabolize cadaverine ...
... cadaverine (1,5-diaminopentane) is produced fermentatively, with the carbon source used preferably being renewable raw ... The production of cadaverine is aided by additionally overexpressing, in the cadaverine-producing recombinant cell, a ... Accumulation of cadaverine in the culture supernatant of recombinant strains of Corynebacterium glutamicum DM1800. C. ... Example 4 Cadaverine Production Using Bacteria The recombinant C. glutamicum DM1800 strains were grown at 30° C. overnight on ...
Cadaverine, Spermine and Spermidine - Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) ... Putrescine and Cadaverine also contribute towards the smells of some living processes. Since they are both poisonous, the body ... Putrescine, Cadaverine, Spermine and Spermidine - Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) →. Page ... Putrescine and Cadaverine also contribute to the distinctive smell of semen, which also contains the related molecules Spermine ...
Cadaverine dihydrochloride. 100 mg. DRE-C10933500. Add to basket Caffeic acid. 100 mg. DRE-C10934700. Add to basket ...
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Biogenic amines such as putrescine, cadaverine, and spermine are formed and degraded as a result of normal metabolic activity ...
Finally, we show in a small cross sectional study of 37 women that the BAs putrescine, cadaverine and tyramine are ... Finally, we show in a small cross sectional study of 37 women that the BAs putrescine, cadaverine and tyramine are ... and cadaverine and between both Mobiluncus spp. and Anaeroglobus spp. with putrescine. Macklaim et al. (2013) in their recent ... Putrescine and Cadaverine are Higher in CST IV Vaginal Microbiome. To determine the actual changes in vaginal BA levels ...
All elapid venoms contained larger molar quantities of putrescine and cadaverine than spermine, but still at levels that are ... and cadaverine. Most venoms contained all four polyamines, although some in essentially trace quantities. Spermine is a ... All elapid venoms contained larger molar quantities of putrescine and cadaverine than spermine, but still at levels that are ... Keywords: polyamines; snake venoms; spermine; spermidine; putrescine; cadaverine; titer; pharmacology; envenomation sequelae ...
The action of bacteria on meat and fish produces a compound called cadaverine. As its name and origin imply, it.... Chemistry ...
Cadaverine Addiction 03:28 8. Schysophaser 03:51 9. Bleeding Anus 02:37 10. Raise! 04:12 11. Expierence 03:09 12. trASHES 02:58 ... STOP 04:42 =================== https://darksystem.bandcamp.com/album/cadaverine-addiction. Topics: X.C.V, Industrial, Rhythmic ...
  • Cadaverine derives from lysine in a pathway that is distinct from that of the other well-characterized ornithine- or arginine-derived polyamines. (frontiersin.org)
  • and H 2 N(CH 2 ) 5 NH 2 , called cadaverine, are foul-smelling compounds found in decaying flesh. (britannica.com)
  • Conjugation of some phenolic and cinnamic compounds with monodansyl cadaverine. (nii.ac.jp)
  • Cadaverine, from the word, cadaver, is often associated with decaying matter and is one of the components that gives carrion its distinctive smell. (frontiersin.org)
  • From the name you might expect Cadaverine to smell like a rotting corpse and while there is certainly an element of that, most people are immediately struck by the overwhelming note of human sperm - at this dilution way, way stronger smelling than real ejaculate - which of course makes it ideal for those seeking to create perfumes with pheromones, sexuality and lust in mind. (pellwall.com)
  • It is usually accompanied by Cadaverine (named after the cadavers that give rise to it), a poisonous syrupy liquid with an equally disgusting smell. (readkong.com)
  • This E. coli strain produces increased amounts of cadaverine following the overexpression of the homologous cadA gene (JP 2002-223770). (justia.com)
  • A further method is the conversion of lysine-HCl into cadaverine by means of the isolated cadA enzyme (JP 2005-060447). (justia.com)
  • The invention relates to cadaverine-producing recombinant microorganisms with a high L-lysine titre, in which polynucleotides which code for lysine decarboxylase are present in an enhanced dose in comparison to microorganisms, which act as the parent strain, which are not modified with regard to this enzyme. (justia.com)
  • Salivary bacteria produce the enzyme lysine decarboxylase which converts lysine to cadaverine. (elsevier.com)
  • A selective and sensitive capillary electrophoresis method with laser-induced fluorescence detection has been developed for the determination of cadaverine and lysine in saliva, as an indicator of lysine decarboxylase enzyme activity. (elsevier.com)
  • Cadaverine:lysine antiporter [Catalyzes cadaverine uptake via H + symport (Km=21μM) and cadaverine export (Km=300 μM) via cadaverine:lysine antiport. (tcdb.org)
  • Cadaverine synthesized via a whole cell biocatalyst reaction using XBHaLDC was purified to polymer grade, and purified cadaverine was successfully used for the synthesis of polyamide 510. (mdpi.com)
  • Indeed, restoring cadaverine synthesis decreases the expression of the speC gene, whose product affects putrescine production. (plos.org)
  • Pentolinium and pentamethonium are both chemical derivatives of cadaverine. (wikipedia.org)
  • Cadaverine is also known by the names 1,5-pentanediamine and pentamethylenediamine. (wikipedia.org)
  • The invention relates to recombinant microorganisms in which polynucleotides which code for lysine decarboxylase are enhanced and, using which, cadaverine (1,5-diaminopentane) is produced fermentatively, with the carbon source used preferably being renewable raw materials such as, for example, glucose, sucrose, molasses and the like. (justia.com)
  • Cadaverine functions in a multitude of cellular processes critical to living organisms. (frontiersin.org)
  • We also address the possible roles rhizosphere and phyllosphere microbes may play in the delivery of exogenous cadaverine near plant organs, and discuss our current understanding of the molecular pathways that contribute to cadaverine homeostasis and response in plants. (frontiersin.org)
  • Cadaverine is at the nexus of several biochemical pathways (Figure 1 ). (frontiersin.org)
  • Initially identified as a lysine decomposition product in organic matter, cadaverine, or 1,5-pentanediamine, is found ubiquitously in the environment. (frontiersin.org)
  • However, data regarding the role of cadaverine in stress response remains conflicted, as some plant systems show enhanced tolerance to stresses in its presence, while others show increased sensitivity to the same stresses. (frontiersin.org)
  • This may contribute to gingival inflammation, while cadaverine contributes to oral malodor. (elsevier.com)
  • 2. Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse. (wikidot.com)
  • In the context of this problem it has now been found that, starting from a lysine-producing microorganism, a cadaverine producer can be generated by introducing an optionally heterologous gene which codes for a lysine decarboxylase. (justia.com)
  • The inventors have made it their object to provide novel methods for the fermentative production of cadaverine from renewable raw materials. (justia.com)
  • Pathoadaption events affecting the cad locus have occurred also in EIEC, silencing cadaverine production. (plos.org)
  • The action of bacteria on meat and fish produces a compound called cadaverine. (bartleby.com)
  • The resulting recombinant XBHaLDC strain was used as a whole cell biocatalyst for the high-level bioconversion of l -lysine into cadaverine without the supplementation of isopropyl β- d -1-thiogalactopyranoside (IPTG) for the induction of protein expression and pyridoxal phosphate (PLP), a key cofactor for an LDC reaction. (mdpi.com)
  • Previous research suggests cadaverine has a role in stress response, with groups reporting an increase in content upon exposure to heat, drought, salt, and oxidative stress. (frontiersin.org)
  • Markedly, exogenous cadaverine application causes alterations in root-system architecture. (frontiersin.org)