Antigens, Neoplasm
Antigens, Surface
Antigens, Protozoan
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
HLA Antigens
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, Helminth
Carcinoembryonic Antigen
Antigens, Viral, Tumor
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
HLA-DR Antigens
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Receptors, Antigen, B-Cell
Antigens, Tumor-Associated, Carbohydrate
Prostate-Specific Antigen
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Antigens, CD15
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
HLA-A2 Antigen
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Antigens, CD8
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Immunoglobulin G
Blood Group Antigens
Hepatitis B Surface Antigens
Cross Reactions
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Amino Acid Sequence
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antibody Specificity
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Rabbits
Receptors, Antigen
CA1 Region, Hippocampal
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Hepatitis B Antigens
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
CA3 Region, Hippocampal
Antigen-Antibody Reactions
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Antigens, CD1
Immune Sera
Antibody Formation
Antigens, Differentiation
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
B-Lymphocytes
Calcium-Transporting ATPases
MART-1 Antigen
Cells, Cultured
HIV Antigens
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Immunoenzyme Techniques
Base Sequence
Epstein-Barr Virus Nuclear Antigens
Antigens, CD19
Sarcoplasmic Reticulum
Antibodies
CA-19-9 Antigen
Antigens, Heterophile
Hepatitis B Core Antigens
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Immunodiffusion
Autoantigens
Antigen-Antibody Complex
Immunoglobulin M
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Antigens, Thy-1
CA-125 Antigen
Thapsigargin
Cell Membrane
Forssman Antigen
H-Y Antigen
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
HLA-DQ Antigens
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Simian virus 40
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Electrophoresis, Polyacrylamide Gel
Calcium Channel Blockers
Fura-2
Receptors, Antigen, T-Cell, alpha-beta
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Immunohistochemistry
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Immunity, Cellular
Sodium-Calcium Exchanger
CTLA-4 Antigen
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Caffeine
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Guinea Pigs
Calcium Channels, L-Type
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Antigens, CD79
Sensitivity and Specificity
Cytosol
Blotting, Western
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Hemagglutination Tests
CD8-Positive T-Lymphocytes
Patch-Clamp Techniques
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
gp100 Melanoma Antigen
Inositol 1,4,5-Trisphosphate
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Lewis Blood-Group System
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
Ki-67 Antigen
Cattle
Antigens, CD2
Cloning, Molecular
Antigens, T-Independent
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Cytotoxicity, Immunologic
Tumor Cells, Cultured
Hepatitis B e Antigens
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Antigens, CD28
Autoantibodies
Mice, Transgenic
Hypersensitivity, Delayed
Membrane Proteins
Protein Binding
Immunoassay
Immunoblotting
Minor Histocompatibility Antigens
Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.
Recombinant Fusion Proteins
Hybridomas
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
HLA-B27 Antigen
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Transfection
HLA-C Antigens
Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
Antigens, CD58
Fluorescent Dyes
Ryanodine Receptor Calcium Release Channel
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Antigens, CD1d
Chelating Agents
HLA-A1 Antigen
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Inositol 1,4,5-Trisphosphate Receptors
Peptide Fragments
HLA-B7 Antigen
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
HLA-DR4 Antigen
Calmodulin
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Glycoproteins
Calcium-Binding Proteins
ABO Blood-Group System
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
HLA-DR3 Antigen
Agglutination Tests
Erythrocytes
Mutation
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Vaccines, Synthetic
Antigens, CD20
Antigens, CD34
Binding Sites, Antibody
Isoantigens
Antigens, CD27
A member of the tumor necrosis factor receptor superfamily found on most T-LYMPHOCYTES. Activation of the receptor by CD70 ANTIGEN results in the increased proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
HLA-A24 Antigen
Cancer Vaccines
Dose-Response Relationship, Immunologic
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Adenosine Triphosphate
Vaccination
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Paracrine changes in the peritoneal environment of women with endometriosis. (1/616)
During the past decade, macrophage-derived substances such as prostanoids, cytokines, growth factors and angiogenic factors have been detected in the peritoneal fluid of women with endometriosis. In particular, growth-promoting and angiogenic factors are considered to be substantially involved in the pathogenesis of endometriosis. In this study, vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta) and intercellular adhesion molecule 1 (ICAM-1), substances recently detected in the peritoneal fluid of women with endometriosis, were assessed with regard to their concentrations in different stages of endometriosis and changes of the peritoneal paracrine activity after medical treatment with a gonadotrophin releasing hormone agonist (GnRHa). Peritoneal fluid was obtained from patients with endometriosis during laparoscopy before and after a 4-month treatment with a GnRHa. VEGF, TGF-beta and ICAM-1 could be detected in all women presenting with various stages of active endometriosis. After GnRHa therapy, all patients showed significant decreases in mean concentrations of VEGF (194+/-77 pg/ml), TGF-beta (902+/-273 pg/ml) and ICAM-1 (157+/-52 ng/ml). Patients with stage III and IV endometriosis (according to the rAFS score) had much higher concentrations of VEGF and TGF-beta before treatment compared with those patients with mild endometriosis (rAFS stages I and II). The most striking decrease in concentration was for TGF-beta, from 902 pg/ml before to 273 pg/ml after therapy. These results indicate an important role for paracrine activity in the establishment and maintenance of endometriosis. Indeed, treatment with a GnRHa may reduce paracrine activity in the peritoneal cavity via hypo-oestrogenism and provide proof of successful therapy. (+info)Comparison of standard and CA-125 response criteria in patients with epithelial ovarian cancer treated with platinum or paclitaxel. (2/616)
PURPOSE: To assess CA-125 as a measure of response in patients treated with paclitaxel. PATIENTS AND METHODS: One hundred forty-four patients treated with paclitaxel derived from four different trials and 625 patients treated with platinum from two trials were analyzed using precisely defined 50% and 75% reductions in CA-125. The standard and CA-125 response rates to paclitaxel and platinum were compared. In addition, we analyzed individual patient groups in which there was a difference in response according to the two response criteria. RESULTS: Patients with stable disease as determined by standard criteria who were treated with platinum and responded according to CA-125 criteria have an improved median progression-free survival compared with patients with stable disease who did not respond according to CA-125 criteria (10.6 v 4.8 months; P<.001). Standard and CA-125 response rates for patients treated with platinum (58.93% v 61.31%, respectively) and paclitaxel (30.65% v 31.67%, respectively) were very similar, as were rates of false-positive prediction of response by CA-125 (platinum 2.2% and paclitaxel 2.9%). Responders to paclitaxel had a significantly improved progression-free survival compared with non-responders by both standard criteria (median progression-free survival, 6.8 v 2.5 months; P<.001) and CA-125 criteria (median progression-free survival, 6.8 v 3.4 months; P<.001). CONCLUSION: Forassessing activity of therapy for ovarian cancer, these data show that precise 50% or 75% CA-125 response criteria are as sensitive as standard response criteria. We propose that they may be used as a measure of response in lieu of or in addition to standard response criteria in clinical trials involving epithelial ovarian cancer. Sensitivity is maintained whether patients are treated with platinum or paclitaxel. (+info)Fluctuations in CA 125 and CA 15-3 serum concentrations during spontaneous ovulatory cycles. (3/616)
The aim of this study was to investigate cycle dependent changes of serum CA 125 and CA 15-3 concentrations during spontaneous ovulatory cycles. Twenty apparently healthy women with spontaneous menstrual cycles attending our infertility clinic were included. Of these women, 18 had occluded tubes as a result of sterilization. Ovulation was confirmed by luteinizing hormone test and ultrasonography and, to exclude endometriosis, a laparoscopy was performed. Serum samples for CA 125, CA 15-3, 17 beta-oestradiol and progesterone determinations were taken every second day starting on the 2nd day of the cycle until the 7th day of the next cycle. After correction for inter-individual variation in serum concentrations, highest CA 125 concentrations were found during the menstruation. During the follicular and peri-ovulatory phase CA 125 serum concentrations were lowest. For CA 15-3, serum concentrations were not statistically different throughout the cycle. CA 125 and oestradiol concentrations were negatively correlated, CA 15-3 and oestradiol concentrations were positively correlated. Absolute serum concentrations of both CA 125 and CA 15-3 vary among females. Within the female, fluctuations of CA 125 are phase related. In the population studied most of the patients had tubal obstruction and high CA 125 serum concentrations during menstruation, which revokes the theory that the menstrual rise of CA 125 is due only to retrograde menstruation. (+info)Artificial neural network models for the preoperative discrimination between malignant and benign adnexal masses. (4/616)
OBJECTIVE: The aim of this study was to generate and evaluate artificial neural network (ANN) models from simple clinical and ultrasound-derived criteria to predict whether or not an adnexal mass will have histological evidence of malignancy. DESIGN: The data were collected prospectively from 173 consecutive patients who were scheduled to undergo surgical investigations at the University Hospitals, Leuven, between August 1994 and August 1996. The outcome measure was the histological classification of excised tissues as malignant (including borderline) or benign. METHODS: Age, menopausal status and serum CA 125 levels and sonographic features of the adnexal mass were encoded as variables. The ANNs were trained on a randomly selected set of 116 patient records and tested on the remainder (n = 57). The performance of each model was evaluated using receiver operating characteristic (ROC) curves and compared with corresponding data from an established risk of malignancy index (RMI) and a logistic regression model. RESULTS: There were 124 benign masses, five of borderline malignancy and 44 invasive cancers (of which 29% were metastatic); 37% of patients with a malignant or borderline tumor had stage I disease. The best ANN gave an area under the ROC curve of 0.979 for the whole dataset, a sensitivity of 95.9% and specificity of 93.5%. The corresponding values for the RMI were 0.882, 67.3% and 91.1%, and for the logistic regression model 0.956, 95.9% and 85.5%, respectively. CONCLUSION: An ANN can be trained to provide clinically accurate information, on whether or not an adnexal mass is malignant, from the patient's menopausal status, serum CA 125 levels, and some simple ultrasonographic criteria. (+info)Combined inhibin and CA125 assays in the detection of ovarian cancer. (5/616)
BACKGROUND: The reproductive hormone inhibin has been used as a diagnostic marker of ovarian mucinous and granulosa cell cancers. The aims of this study were to develop a new inhibin immunofluorometric assay (alphaC IFMA) to replace an inhibin RIA as a diagnostic marker of these ovarian cancers and to assess whether the alphaC IFMA in combination with CA125, which detects serous cancers, leads to an improved biochemical diagnosis of all ovarian cancers. METHODS: Serum inhibin concentrations were determined in healthy postmenopausal women (n = 165) and women with ovarian cancers (n = 154), using an inhibin RIA and an alphaC IFMA, which detects inhibin forms containing the alphaC subunit as well as the free alphaC subunit. RESULTS: The alphaC IFMA gave a similar or better discrimination of mucinous (90% vs 71%) and granulosa cell (100% vs 100%) cancers compared with the inhibin RIA. Combination of CA125 and alphaC IFMA values by canonical variate analysis or by multiROC analysis showed that the percentage of all ovarian cancers detected was significantly increased compared with either CA125 or alphaC IFMA alone. CONCLUSIONS: The alphaC IFMA shows a similar or better specificity compared with the RIA, but with increased sensitivity. In combination with CA125, the alphaC IFMA provides an effective dual test for the detection of the majority (90%) of ovarian cancers. (+info)Intraperitoneal hyaluronan production in stable continuous ambulatory peritoneal dialysis patients. (6/616)
OBJECTIVE: Several cytokines and proteins are excreted intraperitoneally during the course of peritonitis and stable states in continuous ambulatory peritoneal dialysis (CAPD) patients. Dialysate hyaluronan (HYA) is also regarded as a marker of peritoneal healing during bacterial peritonitis. We examined here, intraperitoneal HYA production in stable CAPD patients and compared the results to those of the peritoneal equilibration test (PET), the length of time on dialysis, and other marker proteins. DESIGN: We determined the concentration of HYA and other marker proteins in the 4-hour-dwell dialysate at 1-year intervals. SETTING: CAPD unit in Hitachi General Hospital. PATIENTS: The subjects were 46 stable CAPD patients who underwent 104 PETs. RESULTS: A correlation was found between the length of time on dialysis and the amount of HYA excretion in the 4-hr-dwell dialysate (r = 0.403, p < 0.001). A positive but weak correlation was found between the dialysate-to-plasma ratio of the creatinine concentration and dialysate HYA excretion (r = 0.229, p < 0.05). Seven patients were over the 90th percentile in both the concentration of HYA (>349.2 ng/mL) and the amount of HYA (>743.6 microg/4-hr dwell). Five patients exceeded 1000 microg of HYA excretion in the 4-hr-dwell dialysate, 4 of whom showed an abrupt increase of HYA excretion to more than 1000 microg/4-hr dwell, and discontinued CAPD within 6 months due to ultrafiltration failure. Two of these 4 patients were diagnosed with sclerosing encapsulating peritonitis at autopsy. CONCLUSION: Intraperitoneal HYA production increased with both higher permeable membrane and the length of time on CAPD. Monitoring of HYA in the peritoneal dialysate may be useful as a marker to assess functional and morphological changes in the peritoneum in long-term CAPD patients. (+info)Serum CA-125 values on the day of oocyte retrieval are not predictive of subsequent pregnancy with in-vitro fertilization. (7/616)
In the clinical management of in-vitro fertilization (IVF) patients it would be very useful to know, before the embryo transfer, whether or not there is a significant chance of pregnancy in that cycle. If low, it would be better to freeze the embryos and postpone the embryo transfer to a subsequent cycle. For this reason, a retrospective study was carried out to investigate the correlations between the serum CA-125 values before embryo transfer and the clinical outcome of that IVF cycle. Women aged <40 years undergoing a complete infertility evaluation including laparoscopy and receiving gonadotrophin-releasing hormone analogue (GnRHa) suppression followed by purified follicle stimulating hormone (FSH) for IVF-embryo transfer were entered into the study. Ninety-seven cycles qualified for evaluation (26 pregnant and 71 non-pregnant cycles). CA-125 concentrations on the day of oocyte retrieval were significantly lower in the pregnant versus non-pregnant cycles in both non-endometriosis and endometriosis patients. To evaluate the existence of a cut-off value of CA-125 which would allow the prediction of a possible pregnancy with sufficient specificity and sensitivity, a receiver operating characteristic curve analysis was performed. This analysis demonstrated the absence of any predictive value of the subsequent pregnancy for CA-125 concentrations. For this reason, and in contrast with previous findings, CA-125 determinations before the embryo transfer in IVF patients do not appear to be a useful tool for clinicians to use in predicting the outcome of IVF in any given cycle. (+info)Ultrasound assessment of ovarian cancer risk in postmenopausal women with CA125 elevation. (8/616)
We have previously shown that, in asymptomatic post-menopausal women, serum CA125 elevation is associated with a 36-fold increase in risk of ovarian cancer. This study was undertaken to assess the value of pelvic ultrasound for further stratification of ovarian cancer risk. Of 22,000 post-menopausal women, aged > or = 45 participating in an Ovarian Cancer Screening Trial, 741 with a CA125 > or = 30 U ml(-1) underwent pelvic ultrasonography. Twenty index cancers (primary invasive epithelial carcinomas of the ovary and fallopian tube) were diagnosed amongst these 741 women during a median follow-up of 6.8 years. Ultrasound results separated the women with CA125 elevation into two groups. Those with normal ovarian morphology had a cumulative risk (CR) of index cancer of 0.15% (95% confidence interval (CI) 0.02-1.12) which is similar to that of the entire population of 22,000 women (0.22%, 95% CI 0.18-0.30). In contrast, women with abnormal ovarian morphology had a CR of 24% (15-37) and a significantly increased relative risk (RR) of 327 (156-683). Ultrasound can effectively separate post-menopausal women with raised CA125 levels into those with normal scan findings who are not at increased risk of index cancer and those with abnormal findings who are at substantially increased risk of index cancer. (+info)
Post-treatment alterations of serum cancer antigen 125, cancer antigen 19.9 and carcinoembryonic antigen levels in patients...
Cancer Antigen (CA) 27.29 - US Bio-Chem Medical Services
A Study of the Addition of Avastin (Bevacizumab) to Carboplatin and Paclitaxel Therapy in Patients With Ovarian Cancer - Full...
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Oncology
Tumor markers including alphafetoprotein (AFP), Beta Human Chorionic Gonadotropin (HCG), Carcinoembionic Antigen (CEA), CA 125 ... Scholler, Nathalie; Urban, Nicole (2007-12-01). "CA125 in Ovarian Cancer". Biomarkers in Medicine. 1 (4): 513-523. doi:10.2217/ ... ISBN 978-0-00-725092-9. Vickers, Andrew (1 March 2004). "Alternative Cancer Cures: "Unproven" or "Disproven"?". CA: A Cancer ... Prostate specific antigen (PSA). Treatment depends on the size and type of cancer. Breast cancer Treatment options include ...
Liver cancer
CA 19-9), carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125). These tumor markers are found in primary liver cancers ... Liver markers that can be increased with intrahepatic CCA are carcinoembryonic antigen (CEA), CA19-9, and CA-125. These are ... Jemal, A; Bray, F; Center, MM; Ferlay, J; Ward, E; Forman, D (Mar-Apr 2011). "Global cancer statistics". CA: A Cancer Journal ... Cholangiocarcinoma can be detected with these commonly used tumor markers: carbohydrate antigen 19-9 ( ...
Pancreatic pseudocyst
Diagnosis of Pancreatic pseudocyst can be based on cyst fluid analysis: Carcinoembryonic antigen (CEA) and CA-125 (low in ...
Ovarian cancer
There is no specific marker for immature teratomas, but carcinoembryonic antigen (CEA), CA-125, CA19-9, or AFP can sometimes ... CA-125 levels in premenopausal people over 200 U/mL may indicate ovarian cancer, as may any elevation in CA-125 above 35 U/mL ... CA-125 levels are not accurate in early stage ovarian cancer, as fully half of stage I ovarian cancer patients have a normal CA ... A blood test for a marker molecule called CA-125 is useful in differential diagnosis and in follow up of the disease, but it by ...
Abagovomab
... is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly ... antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is ... 3009.3CA125. "Medical News: ESGO: Anti-CA125 Fails to Slow Ovarian Cancer - in Meeting Coverage, ESGO from". MedPage Today. ... Abagovomab does not bind directly to CA-125, but it works as a "surrogate" ...
Oncology
Vickers, Andrew (1 March 2004). "Alternative Cancer Cures: "Unproven" or "Disproven"?". CA: A Cancer Journal for Clinicians. 54 ... Tumor markers including alphafetoprotein (AFP),[47] Beta Human Chorionic Gonadotropin (HCG),[47] Carcinoembionic Antigen (CEA), ... "CA125 in Ovarian Cancer". Biomarkers in Medicine. 1 (4): 513-523. doi:10.2217/17520363.1.4.513. ISSN 1752-0363. PMC 2872496 ...
Liver tumor
CA 19-9), carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125). These tumour markers are found in primary liver ... Cholangiocarcinoma can be detected with these commonly used tumor markers: carbohydrate antigen 19-9 ( ...
Reference ranges for blood tests
June 2008). "Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific ... Böttiger LE, Svedberg CA (1967). "Normal erythrocyte sedimentation rate and age". Br Med J. 2 (5544): 85-87. doi:10.1136/bmj. ... Carcinoembryonic Antigen(CEA) at MedicineNet Luboldt, Hans-Joachim; Schindler, Joachim F.; Rübben, Herbert (2007). "Age- ... R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. ...
Hyperpolarization (physics)
When performing this procedure at ~70 K (i.e. with liquid nitrogen), para-hydrogen is enriched from 25% to ca. 50%. When ... Prostate-Specific Antigen) and has been contributing to prostate cancer. There are a lot of biomarkers are considering as being ... Proton NMR signals with ca. 10,000-fold increased intensity can be obtained compared to NMR signals of the same organic ... CA-125), Human Immunodeficiency Virus -Ribonucleic Acid (HIV RNA), B-type Natriuretic Peptide (BNP).27and Lymphoma cell (Ramos ...
Cancer biomarker
Examples: Prostate-specific antigen, and CA-125 Antibodies to cancer antigens Examples: Merkel cell polyomavirus DNA Examples: ... Bantis, A; Grammaticos, P (Sep-Dec 2012). "Prostatic specific antigen and bone scan in the diagnosis and follow-up of prostate ... Gupta, Digant; Lis, Christopher G. (2009-10-09). "Role of CA125 in predicting ovarian cancer survival - a review of the ... CA-125 (Ovarian Cancer), CA19.9 (Pancreatic Cancer), CEA (Colorectal Cancer), EGFR (Non-small-cell lung carcinoma), HER-2 ( ...
List of MeSH codes (D23)
... ca-15-3 antigen MeSH D23.050.285.050.119 - ca-19-9 antigen MeSH D23.050.285.050.225 - ca-125 antigen MeSH D23.050.285.062 - ... ca-15-3 antigen MeSH D23.050.550.325.119 - ca-19-9 antigen MeSH D23.050.550.325.225 - ca-125 antigen MeSH D23.050.550.395 - ... ca-15-3 antigen MeSH D23.101.840.075.119 - ca-19-9 antigen MeSH D23.101.840.075.225 - ca-125 antigen MeSH D23.101.840.100 - ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ...
Monica McLemore
McLemore moved to the University of California, San Francisco for her graduate studies, where she studied CA-125; an antigen ... McLemore, Monica Rose; University of California, San Francisco; Nursing; University of California, San Francisco (2010). An ... PTBi-California looks to mitigate for the disproportionate impact that preterm births have on already marginalised communities ... McLemore was part of the preterm birth initiative (PTBi-California), which looks to understand why preterm births mainly occur ...
CA-125
Yin BW, Lloyd KO (Jul 2001). "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16". The ... Yin BW, Dnistrian A, Lloyd KO (Apr 2002). "Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene". International ... Boivin M, Lane D, Piché A, Rancourt C (Dec 2009). "CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian ... Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) CA-125 at Lab Tests Online CA-125 analyte ...
125 (number)
... also known as CA125, is an abbreviation for cancer antigen 125 125 High Street is a 30-floor high-rise in Boston 125th ( ... California USNS Mission San Jose (T-AO-125), a US Navy fleet oiler during World War II USS Tide (AM-125), a US Navy minesweeper ... 125 is the cube of 5. It can be expressed as a sum of two squares in two different ways, 125 = 10² + 5² = 11² + 2². 125 and 126 ... 125 is also: The year AD 125 or 125 BC 125 AH is a year in the Islamic calendar that corresponds to 742 - 743 CE 125 Liberatrix ...
Dana-Farber Cancer Institute
... which enables the immune system to recognize antigens. 1982: Dana-Farber researchers develop and apply the CA-125 blood test ...
Jean-Claude Weill
Immunol., 22, (1998), p. 379-385 Weill, J.-C. and Reynaud, C.-A., « DNA polymerases in adaptive immunity », Nature Reviews ... Hypermutation generating the sheep Ig repertoire is an antigen-independent process », Cell, 80, (1995), p. 115-125 Weill J.-C. ... C.-A, « Human marginal zone B cells. », Annu. Rev. Immunol., 27, (2009), p. 267-285 "Google Scholar". "Académie des sciences ... and Reynaud, C.-A., « GALT versus bone marrow models of B cell ontogeny », Develop. Comp. ...
Tumor marker
CA 19-9, CA 72-4 Liver: CEA, AFP Oesophagus: CEA, Cyfra 21-1 Thyroid: CEA, NSE Lung: CEA, CA 19-9, CA 125, NSE, Cyfra 21-1 ( ... Bagan P, Berna P, Assouad J, Hupertan V, Le Pimpec Barthes F, Riquet M (January 2008). "Value of cancer antigen 125 for ... CA 15-3, Cyfra 21-1 Ovary: CEA, CA 19-9, CA 125, AFP, BHCG Uterine: CEA, CA 19-9, CA 125, Cyfra 21-1, SCC Prostate: PSA, FPSA ... "Definition of CA 27-29. From MedicineNet. Last Editorial Review: 6/14/2012". gpnotebook.co.uk > ca-19-9 Retrieved November 2011 ...
Selectin
St Hill CA (June 2011). "Interactions between endothelial selectins and cancer cells regulate metastasis". Frontiers in ... One of the reported ligands for E-selectin is the sialylated Lewis X antigen (SLex). Eosinophils, like neutrophils, use ... Bochner BS, Sterbinsky SA, Bickel CA, Werfel S, Wein M, Newman W (January 1994). "Differences between human eosinophils and ... Wein M, Sterbinsky SA, Bickel CA, Schleimer RP, Bochner BS (March 1995). "Comparison of human eosinophil and neutrophil ligands ...
KLK15
Takayama TK, Carter CA, Deng T (2001). "Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human ... 276 (1): 125-33. doi:10.1006/bbrc.2000.3448. PMID 11006094. Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression ...
Minretumomab
"TAG-72 antigen". NCI Dictionary of Cancer Terms. National Cancer Institute. 2011-02-02. Scott AM, Wolchok JD, Old LJ (March ... tumor-associated glycoprotein 72 mucin levels in tumor and serum of colorectal patients as measured by the quantitative CA 72-4 ... is a mouse monoclonal antibody that was designed for the treatment of cancers that express the TAG-72 antigen. This includes ... Iodine (125I) minretumomab is an iodine-125 radiolabelled derivative that was developed for the detection of tumours in ...
Semen - Simple English Wikipedia, the free encyclopedia
Berkeley, Calif.: University of California Press. ISBN 0-520-08096-3. .. CS1 maint: extra text: authors list (link). ... Prostate-specific antigen (PSA) - this is an enzyme (a chemical that speeds up chemical reactions) which causes the semen to ... San Francisco, Calif.: HarperSanFrancisco. p. 576. ISBN 0-06-250923-3. .. *↑ Gary J. Clyman. "Sexual Kung Fu [ch. 8]". The Chi ... 132 (2): 123-125.. (In French.) *↑ S. Weidinger; J. Ring, F.M. Köhn (2005). "IgE-mediated Allergy against Human Seminal Plasma" ...
Lesional demyelinations of the central nervous system
... small clusters of microglial cells with enhanced major histocompatibility complex class II antigen, CD45 and CD68 antigen ... Rus H, Pardo CA, Hu L, et al. (August 2005). "The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory ... Haegele KF, Stueckle CA, Malin JP, Sindern E (February 2007). "Increase of CD8+ T-effector memory cells in peripheral blood of ... Given CA, Stevens BS, Lee C (1 January 2004). "The MRI appearance of tumefactive demyelinating lesions". AJR Am J Roentgenol. ...
Chimeric antigen receptor T cell
Jacobson CA, Ritz J (November 2011). "Time to put the CAR-T before the horse". Blood. 118 (18): 4761-2. doi:10.1182/blood-2011- ... Identification of good antigens has been challenging: such antigens must be highly expressed on the majority of cancer cells, ... After an antigen is bound to the external antigen recognition domain, CAR receptors cluster together and transmit an activation ... T cells are genetically engineered to express chimeric antigen receptors specifically directed toward antigens on a patient's ...
Étienne de Harven
Harven, E.; Soligo, D.; Christensen, H. (1990). "Double labelling of cell surface antigens with colloidal gold markers". The ... De Harven, E. (1977). "Electron Microscopy: Remarks on 40 Years Of Ultrastructural Explorations". CA: A Cancer Journal for ... where he researched the marking of antigens on the surface of lymphocytes. As former President of the Microscopy Society of ... p. 125. ISBN 978-1-4419-0305-1.. Kalichman, Seth C. (2009). Denying AIDS: conspiracy theories, pseudoscience, and human tragedy ...
HLA-G
... histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is ... Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK ... McIntire RH, Hunt JS (2005). "Antigen presenting cells and HLA-G--a review". Placenta. 26 Suppl A: S104-9. doi:10.1016/j. ... "Entrez Gene: HLA-G HLA-G histocompatibility antigen, class I, G". Castelli, Erick C.; Mendes-Junior, Celso T.; Veiga-Castelli, ...
Avidity
Janeway CA, Travers P, Walport M, Shlomchik MJ (2001). Immunobiology (5th ed.). New York: Garland Science. p. 104. ISBN 0-8153- ... For example, IgM is said to have low affinity but high avidity because it has 10 weak binding sites for antigen as opposed to ... Calculation of binding affinity for bimolecular reaction (1 antibody binding site per 1 antigen): [ Ab ] + [ Ag ] ↽ − − ⇀ [ ... is the antigen concentration, either in free ([Ab],[Ag]) or bound ([AbAg]) state. calculation of association constant (or ...
Endometriosis
CA-125 levels appear to fall during endometriosis treatment, but it has not shown a correlation with disease response. Another ... Hirsch M, Duffy J, Davis CJ, Nieves Plana M, Khan KS (October 2016). "Diagnostic accuracy of cancer antigen 125 for ... The one biomarker that has been in use over the last 20 years is CA-125. A 2016 review found that this biomarker was present in ... Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L (2017). "Oxidative Stress and ...
Listeria monocytogenes
Lowry F (2008-05-15). "Live Listeria Vaccine Proves Safe Against End-Stage Cervical Ca in Human Trial". Ob. Gyn. News. 43 (10 ... Chu NJ, Armstrong TD, Jaffee EM (April 2015). "Nonviral oncogenic antigens and the inflammatory signals driving early cancer ... 10 (1): 125-59. doi:10.1128/CMR.10.1.125. PMC 172946. PMID 8993861. "103051F-EN-RevC" (PDF). Hologic. Archived from the ...
Microvesicles
San Diego, CA: Academic Press. pp. 453-67. ISBN 978-0123878373. Vanwijk, M; Vanbavel, E; Sturk, A; Nieuwland, R (2003). " ... CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... This mechanism of action can be used in processes such as antigen presentation, where MHC molecules on the surface of ... For example, those released from antigen-presenting cells (APCs), such as B cells and dendritic cells, are enriched in proteins ...
Rak prostate
"Ca. 61 (2): 69-90. doi:10.3322/caac.20107. PMID 21296855.. *^ Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et ... Androgeni receptor pomaže ćelijama raka da prežive.[74] Prostatski specifični membranski antigen (PSMA) podstiče razvoj raka ... "CA: A Cancer Journal for Clinicians. 68 (6): 394-424. doi:10.3322/caac.21492. PMID 30207593.. ... Filson CP, Marks LS, Litwin MS (8. 5. 2015). "Expectant management for men with early stage prostate cancer". Ca. 65 (4): 265- ...
Oral candidiasis
Journal of the California Dental Association. 41 (4): 263-8. PMID 23705242. Yamada T, Alpers DH, et al. (2009). Textbook of ... in persons with blood group O and in non-secretors of blood group antigens in saliva. Increased rates of Candida carriage are ... CA: A Cancer Journal for Clinicians. 62 (6): 400-22. doi:10.3322/caac.21157. PMID 22972543. Odell EW (Editor) (2010). Clinical ... 5 (2): 125-57. doi:10.1177/10454411940050020101. PMID 7858080. Li, X; Lei, L; Tan, D; Jiang, L; Zeng, X; Dan, H; Liao, G; Chen ...
Lyme disease
OspA antigens, shed by live Borrelia bacteria into urine, are a promising technique being studied.[117] The use of nanotrap ... "Phac-aspc.gc.ca. 4 July 2012. Archived from the original on 27 December 2012. Retrieved 15 December 2012.. ... Walsh CA, Mayer EW, Baxi LV (January 2007). "Lyme disease in pregnancy: case report and review of the literature". Obstetrical ... "Agf.gov.bc.ca. Archived from the original on 3 January 2013. Retrieved 15 December 2012.. ...
Proteasome
Peptide antigens are displayed by the major histocompatibility complex class I (MHC) proteins on the surface of antigen- ... Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J (2004). "3". Molecular cell biology (5th ... Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P (July 2000). "Role of the proteasome in Alzheimer's ... Zhang M, Coffino P (March 2004). "Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome ...
CD30
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... CA 15-3. *erbB-2 receptor. *erbB-3 receptor. *Cathepsin D. *Ca 27-29 ...
Ալերգիա - Վիքիպեդիա՝ ազատ հանրագիտարան
1 - antigen; 2 - IgE antibody; 3 - FcεRI receptor; 4 - preformed mediators (histamine, proteases, chemokines, heparin); 5 - ... Marra F, Lynd L, Coombes M, Richardson K, Legal M, Fitzgerald JM, Marra CA (March 2006). "Does antibiotic exposure during ...
Food allergy
1 - antigen. 2 - IgE antibody. 3 - FcεRI receptor. 4 - preformed mediators (histamine, proteases, chemokines, heparin). 5 - ... Cuello-Garcia CA, Brożek JL, Fiocchi A, et al. (2015). "Probiotics for the prevention of allergy: A systematic review and meta- ... Other widely promoted tests such as the antigen leukocyte cellular antibody test and the food allergy profile are considered ... 125] For infants, supplementing their diet with oils high in PUFAs did not affect the risks of food allergies, eczema or asthma ...
Epigenetics
Cooney CA, Dave AA, Wolff GL (August 2002). "Maternal methyl supplements in mice affect epigenetic variation and DNA ... has a 10-40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA).[51] ... Dupont C, Armant DR, Brenner CA (September 2009). "Epigenetics: definition, mechanisms and clinical perspective". Seminars in ... 125] Congenital genetic disease is well understood and it is clear that epigenetics can play a role, for example, in the case ...
Kevin Cooper (prisoner)
CDCR), California Department of Corrections and Rehabilitation. "State of California Inmate Locator". inmatelocator.cdcr.ca.gov ... and when Judge Huff did order retesting she limited the testing to hairs that were proven not to have Antigen roots ( ... Denial of clemency by California Governor Schwarzenegger[edit]. On January 30, 2004, the office of Governor of California ... California Supreme Court upholds stay on execution[edit]. This section of a biography of a living person does not include any ...
乙醯膽鹼酯酶 - 維基百科,自由的百科
Evidence that the antigens of the Yt blood group system are located on human erythrocyte acetylcholinesterase.. Blood. 1992, 80 ... Soreq H, Ben-Aziz R, Prody CA; 等. Molecular cloning and construction of the coding region for human acetylcholinesterase ... Lapidot-Lifson Y, Prody CA, Ginzberg D; 等. Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in ... 1986, 25 (1): 125-30. PMID 3954986. doi:10.1021/bi00349a019.. *. Gaston SM, Marchase RB, Jakoi ER. Brain ligatin: a membrane ...
سرطان پروستات - ویکیپدیا، دانشنامهٔ آزاد
doi:10.3322/CA.2007.0010. PMID 18287387.. *^ "Cancer Stat Facts: Prostate Cancer". National Cancer Institute. Archived from the ... Prostate specific membrane antigen is a transmembrane carboxypeptidase and exhibits folate hydrolase activity.[75] This protein ... Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011). "Global cancer statistics". CA - A Cancer Journal for Clinicians ... Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (March 2008). "Cancer Statistics, 2008". CA Cancer J Clin. 58 (2): 71 ...
Interleukin 15
Klebanoff CA, Finkelstein SE, Surman DR, Lichtman MK, Gattinoni L, Theoret MR, Grewal N, Spiess PJ, Antony PA, Palmer DC, ... Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated ... 28 (1): 116-125. doi:10.1111/sms.12901. PMID 28449327.. *^ Sauce D, Larsen M, Curnow SJ, Leese AM, Moss PA, Hislop AD, Salmon M ... "Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens". Nature. 471 (7337): 220-4. ...
Acute lymphoblastic leukemia
"www.cancer.ca. Retrieved 6 December 2017.. *^ Nelson Essentials of Pediatrics By Karen Marcdante, Robert M. Kliegman, Richard E ... Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors" ... TdT is a protein expressed early in the development of pre-T and pre-B cells, whereas CALLA is an antigen found in 80% of ALL ... Chimeric antigen receptors (CARs) have been developed as a promising immunotherapy for ALL. This technology uses a single chain ...
ಜೀವಕಣದ ಬೀಜಕಣ - ವಿಕಿಪೀಡಿಯ
Saunders WS, Cooke CA, Earnshaw WC (1991). "Compartmentalization within the nucleus: discovery of a novel subnuclear region". ... Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle". EMBO J. 17 (6): 1768-1778. doi:10.1093/ ... Moreno F, Ahuatzi D, Riera A, Palomino CA, Herrero P. (2005). "Glucose sensing through the Hxk2-dependent signalling pathway". ... 125 (125): 127-137. doi:10.1007/s00418-005-0046-4.. *↑ ೨೬.೦ ೨೬.೧ Lamond, Angus I. "Nuclear substructure and dynamics". Current ...
Smallpox
Berkeley: University of California Press. ISBN 978-0-520-24220-3. .. *. Mack T (2003). "A different view of smallpox and ... which measured Variola virus-specific immunoglobulin and antigen were also developed to assist in the diagnosis of infection.[ ... "University of California Press. Archived from the original on 7 September 2008. Retrieved 22 February 2009.. ... Berkeley and Los Angeles: University of California Press. ISBN 978-0-520-23732-2. .. ...
Chemotherapy
E. Crowley, CA. McDevitt, R. Callaghan (2009). Multidrug Resistance in Cancer. Generating Inhibitors of P-Glycoprotein: Where ... The antibody will be targeted at a preferentially expressed protein in the tumour cells (known as a tumor antigen) or on cells ... They bind to the tumor antigen and are internalised, where the linker releases the drug into the cell. These specially targeted ... Bartelink IH; Bredius RG; Belitser SV; Suttorp MM; Bierings M; Knibbe CA; Egeler M; Lankester AC; Egberts AC; Zwaveling J; ...
Coeliac disease
Herter, CA (1908). On infantilism from chronic intestinal infection; characterized by the overgrowth and persistence of flora ... HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ... Bibbins-Domingo K, Grossman DC, Curry SJ, Barry MJ, Davidson KW, Doubeni CA, Ebell M, Epling JW, Herzstein J, Kemper AR, Krist ... Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, ...
Mir-181 microRNA precursor
Murchison EP, Tovar C, Hsu A, Bender HS, Kheradpour P, Rebbeck CA, Obendorf D, Conlan C, Bahlo M, Blizzard CA, Pyecroft S, ... The increased expression of miR-181a in mature T cells increases susceptibility to peptide antigens, while inhibiting the ... suggesting that miR-181a acts as an antigen intrinsic sensitivity "rheostat" during the development of T cells. It has been ... 40 (1): 125. doi:10.1111/j.1365-2052.2008.01780.x. PMID 18945293. Jin W, Grant JR, Stothard P, Moore SS, Guan LL (September ...
Limfocyty T regulatorowe, wolna encyklopedia
DOI: 10.1097/01.TP.0000106470.07410.CA. PMID: 14726768. *↑ R.J. Robb, K.E. Lineburg, R.D. Kuns, Y.A. Wilson i inni. ... Antigen-specific peripheral shaping of the natural regulatory T cell population. „J Exp Med". 205 (13), s. 3105-3117, grudzień ... De novo production of antigen-specific suppressor cells in vivo. „Nat Protoc". 1 (2), s. 653-661, 2006. PMID: 17802642. ... Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. „ ...
Health effects of tobacco
Isaac A. Adler, A.M., M.D". Ca. 30 (5): 295-301. doi:10.3322/canjclin.30.5.295. PMID 6773624.. ... Carcinoembryonic antigen (CEA) is a marker found in several forms of cancer. Levels in exclusive hookah smokers were lower ... Thun MJ, Day-Lally CA, Calle EE, Flanders WD, Heath CW (September 1995). "Excess mortality among cigarette smokers: changes in ... Mahid SS, Minor KS, Soto RE, Hornung CA, Galandiuk S (November 2006). "Smoking and inflammatory bowel disease: a meta-analysis ...
Tüümus - Vikipeedia
Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection., 110 ... Janeway CA Jr, Travers P, Walport M, et al., Generation of lymphocytes in bone marrow and thymus, "Immunobiology: The Immune ... Janeway CA Jr, Travers P, Walport M, et al., Generation of lymphocytes in bone marrow and thymus, "Immunobiology: The Immune ... Ana C. Anderson ja Vijay K. Kuchroo, Expression of Self-antigen in the Thymus A Little Goes a Long Way, 1. detsember 2003 // ...
Organ transplantation
"Healthzone.ca. Archived from the original on 26 February 2012. Retrieved 27 February 2012.. ... and that they have low levels of T cell-independent antigens.[17][19] United Network for Organ Sharing (UNOS) regulations allow ... the period under which a recipient may undergo ABOi transplantation may be prolonged by exposure to nonself A and B antigens.[ ... 125][118] The first partial success was achieved on 3 December 1967, when Christiaan Barnard of Cape Town, South Africa, ...
肺癌 - 维基百科,自由的百科全书
嵌合抗原受體T細胞免疫療法(Chimeric Antigen Receptor T-Cell Immunotherapy)乃是先取得患者自身的T細胞後,在體外以基因工程的技術,使T細胞具有辨識癌細胞的能力後,再回輸到患者身上。被改造後的T細胞即稱為嵌合抗 ... California Environmental Protection Agency. Tobacco Control. 1997, 6 (4): 346-53. PMC 1759599. PMID 9583639. doi:10.1136/tc.6.4 ... Powell CA, Halmos B, Nana-Sinkam SP. Update in lung cancer and mesothelioma 2012. American
Anoreksi
Ca 90 % av alle personer med anoreksi er kvinner.[184] I den norske befolkningen forekommer anoreksi i ca. 20 tilfeller per 100 ... Serodiagnosis of Lyme disease by ELISA using Borrelia burgdorferi flagellum antigen]». Rinsho Byori (Japanese). 39 (8): 891-4. ... Blant yngre kvinner er antallet nye tilfeller ca. 50 per 100 000 per år. Totalt i den norske befolkningen regner vi med at 1-2 ... 13 (1): 125-8. PMID 8477271. doi:10.1002/1098-108X(199301)13:1,125::AID-EAT2260130115,3.0.CO;2-4.. CS1-vedlikehold: Flere navn ...
Colorectal cancer
It has been suggested that the presence of antibodies to Streptococcus bovis/gallolyticus antigens or the antigens themselves ... Ca. 68 (4): 250-281. doi:10.3322/caac.21457. PMID 29846947.. ... Carcinoembryonic antigen blood level measurements follow the ... Palliative care is recommended for any person who has advanced colon cancer or who has significant symptoms.[125][126] ... 125-126 In 2018 the National Cancer Institute stated that "There is no reliable evidence that a diet started in adulthood that ...
Concanavalina A, a enciclopedia libre
... xeralmente Mn2+ e Ca2+). Ten unha simetría D2.[1] A súa estrutura terciaria xa foi determinada,[7] e as bases moleculares da ... "Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and ... "The Journal of Biological Chemistry 125 (1): 45-48.. ; Sumner, J. B.; Gralen, N.; Eriksson-Quensel, I.-B. (1938). "The ...
Sistem imun bahasa Indonesia, ensiklopedia bebas
... oleh pengenal antigen.[59] Respons imun adaptif bersifat spesifik terhadap antigen tertentu dan membutuhkan pengenalan antigen ... Winstanley C, Hart CA (2001). "Type III secretion systems and pathogenicity islands". J Med Microbiol. 50 (2): 116-26. PMID ... Oleh sistem imun, antigen tersebut dianggap sebagai antigen asing dan keberadaannya mendorong sel imun untuk menyerang sel ... Sel T pembantu mengekspresikan reseptor sel T yang mengenali antigen terikat pada molekul MHC kelas II. MHC:antigen juga ...
Golden State Killer
California, The State Bar of. "Sharon M Huddle #105101 - Attorney Search". members.calbar.ca.gov. Retrieved August 13, 2018.. ... Non-secretor: Sperm does not contain blood-group antigens.[127]. *Physically agile and capable of sprinting, bicycling, and ... Huddle went to college in Fresno, California. Afterwards, she attended law school in Sacramento, California. She became an ... 2 million supporting California Proposition 69 authorizing DNA collection from all California felons and certain other ...
Cathepsin D
antigen processing and presentation of exogenous peptide antigen via MHC class II. • proteolysis. • neutrophil degranulation. ... Mueller CA, Kalbacher H (March 2006). "Cathepsin D is present in human eccrine sweat and involved in the postsecretory ... brain antigen processing and regulation of programmed cell death.[17][18][19][20] ...
Ebola virus disease
"First Antigen Rapid Test for Ebola through Emergency Assessment and Eligible for Procurement". World Health Organization. ... "CBC.ca. CBC/Radio-Canada. 12 September 2007. Archived from the original on 19 November 2014.. ... In 2015 a rapid antigen test which gives results in 15 minutes was approved for use by WHO. It is able to confirm Ebola in 92% ... 125] Quarantine, also known as enforced isolation, is usually effective in decreasing spread.[126][127] Governments often ...
疟疾 - 维基百科,自由的百科全书
惡性瘧原蟲帶來的高死亡率和罹病率,造成人類近代史上最大的演化壓力,造成某些對瘧疾有抵抗力的基因篩選出來。不幸地,這些基因通常也會造成紅血球發育不良,導致鐮刀型紅血球疾病、海洋性貧血、蠶豆症、或紅血球表面達菲抗原(英语:Duffy antigens)缺乏[ ... Guerra CA, Hay SI, Lucioparedes LS, Gikandi PW
CA-125: The Test | Cancer Antigen 125
Sometimes CA-125 may be ordered to help detect early ovarian cancer in women at high risk (e.g., BRCA mutation) or to help ... CA-125) is a tumor marker primarily used to monitor treatment of ovarian cancer and to detect whether cancer has come back ... If CA-125 levels rise or stay the same, then the cancer may not be responding to therapy. High CA-125 levels after treatment is ... CA-125 is also used to detect whether cancer has come back after treatment is complete. A series of CA-125 tests that shows ...
Cancer Antigen 125 (CA-125) Test for Cancer: Purpose and Results
The CA-125 blood test can spot proteins made by ovarian cancer, but it doesnt always mean you have cancer. WebMD explains why ... The CA-125 test also may be done if you have a lump in your pelvic area. It will help your doctor figure out the cause of the ... Cancer antigen 125 test Your doctor may order a CA-125 test if youre about to start treatment for ovarian cancer. The test ... The CA-125 test looks for certain proteins in your blood. Ovarian cancer can be the reason for these proteins, but other ...
Cancer antigen 125 (CA125) - Canadian Cancer Society
CA125) is a protein produced by a variety of cells, particularly ovarian cancer cells. It is found in trace amounts in the ... How a CA125 test is done. A CA125 test is a blood test that measures the amount of CA125 protein in the blood. A sample of ... Why a CA125 test is done. A CA125 test may be done: * if the doctor suspects there may be cancer ... CA125). Cancer antigen 125 (CA125) is a protein found on most ovarian cancer cells that is secreted into the blood stream and ...
Cancer Antigen 125 (CA-125) | NorthShore
Read our Cancer Antigen 125 (CA-125) encyclopedia resources online. ... CA-125) test that can help show if some types of cancer are present. Covers its use to check how well treatment for ovarian ... Cancer Antigen 125 (CA-125). Skip to the navigation Test Overview. Cancer antigen 125 (CA-125) is a protein found on the ... CA-125 is used as a tumor marker, which means the test can help show if some types of cancer are present. Most often, the CA- ...
Cancer Antigen 125 (CA-125) - WellSpan Health Library
CA-125) test that can help show if some types of cancer are present. Covers its use to check how well treatment for ovarian ... Cancer antigen 125 (CA-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other ... CA-125 is used as a tumor marker, which means the test can help show if some types of cancer are present. Most often, the CA- ... High values of CA-125 in a woman who has been treated for ovarian cancer may mean that the cancer has returned. Often the high ...
Cancer Antigen 125 (CA-125) Test
CA-125) test that can help show if some types of cancer are present. Covers its use to check how well treatment for ovarian ... Cancer Antigen 125 (CA-125) Test. Test Overview. Cancer antigen 125 (CA-125) is a protein found on the surface of many ovarian ... CA-125 is used as a tumor marker, which means the test can help show if some types of cancer are present. Most often, the CA- ... High levels of CA-125 are a strong sign that the cancer started in the ovary. But other types of cancer can increase CA-125 ...
Cancer Antigen 125 (CA-125), Human | LeeBio.com
CA-125) tumor marker for Ovarian and other malignant cancers for research and in vitro diagnostic manufacturing - Inquire for ... Home / Antigens / Enzymes / Antigens / Standards / Controls / Proteins / Cancer Antigen 125 (ca-125) ... CA125) is a surface antigen associated with epithelial ovarian cancer. In serum, CA125 is associated with a high molecular ... Low Cross Contamination: CA 15-3, CEA, CA 19-9. Formulation. Solution in phosphate buffered saline pH 7.4 with 3% sucrose and ...
Cancer Antigen 125 (CA-125) Mouse Monoclon | LeeBio.com
CA-125) monoclonal antibody for research, life science and manufacturing uses - Inquire for more details! ... Antigens , Enzymes. We produce and manufacture high quality antigens, proteins and enzymes for a wide range of life science ... Capture Ab: 151-29 - anti-Human CA-125 Monoclonal Antibody. Detection Ab: 151-30 - anti-Human CA-125 Monoclonal Antibody. ...
Cancer Antigen 125 (CA-125) (human) ELISA Kit | K4803 | BioVision, Inc.
Colorimetric Assay for Quantitative measurement of human CA-125 in serum, plasma, urine & cell culture supernatants. Detection ... Milpitas, CA 95035.. Tel: 408.493.1800. Fax: 408.493.1801. Toll Free: 800.891.9699 (US Only). Tech Support: [email protected]. ... CA-125 Ab-coated Microplate, 96 wells. • Wash Buffer (20x). • Human CA-125 Standard. • Assay Diluent (5x). • Detection Antibody ... The minimum detectable dose of CA-125 is typically less than 0.6 U/ml. Detection Range: 0.6 U/ml - 400 U/ml. The intra-Assay ...
Reference limits for chromogranin A, CYFRA 21-1, CA 125, CA 19-9 and carcinoembryonic antigen in patients with chronic kidney...
... cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in ... CA 19-9 and carcinoembryonic antigen in patients with chronic kidney disease. Mikkelsen, Gustav; Åsberg, Arne; Hultström, Maria ... Estimated reference limits for plasma CA 125, CA 19-9 and CEA were approximately the same as for healthy populations. Serum ... Reference limits for chromogranin A, CYFRA 21-1, CA 125, ...
ISRCTN - ISRCTN87786644: A randomised trial in relapsed ovarian cancer, early treatment based on Cancer Antigen (CA) 125...
A randomised trial in relapsed ovarian cancer, early treatment based on Cancer Antigen (CA) 125 levels alone versus delayed ... A randomised trial in relapsed ovarian cancer, early treatment based on Cancer Antigen (CA) 125 levels alone versus delayed ... 2. In complete remission with a normal CA125 since first-line platinum containing chemotherapy. 3. A normal CA125 result within ... Following a raised CA125 result patients are randomised to receive either delayed treatment until patient shows clinical signs ...
CA125 elisa kit | Mouse Carbohydrate Antigen 125 (CA125) ELISA Kit-P06731.3
Mouse Carbohydrate Antigen 125 (CA125) ELISA Kit-P06731.3 (MBS264824) product datasheet at MyBioSource, ELISA Kits ... carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100 UniProt Protein Name Carcinoembryonic antigen- ... The ELISA analytical biochemical technique of the MBS264824 kit is based on CA125 antibody-CA125 antigen interactions ( ... CA125 elisa kit :: Mouse Carbohydrate Antigen 125 (CA125) ELISA Kit. Catalog #. MBS264824 .mycenter { display: block; margin- ...
OCM-CA125 elisa kit | Bovine Ovarian Cancer Marker/Carbohydrate Antigen 125 ELISA Kit
Bovine Ovarian Cancer Marker/Carbohydrate Antigen 125 ELISA Kit (MBS023627) product datasheet at MyBioSource, ELISA Kits ... The ELISA analytical biochemical technique of the MBS023627 kit is based on OCM-CA125 antibody-OCM-CA125 antigen interactions ( ... OCM-CA125 Bovine OCM-CA125. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... OCM-CA125 elisa kit :: Bovine Ovarian Cancer Marker/Carbohydrate Antigen 125 ELISA Kit. ...
Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and...
Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and ... Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and ... Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and ... The specificity of CA 125 at upper limits of 30 and 50 U/mL was increased from 97.0 and 99.5%, respectively, to 98.9 and 99.9% ...
MIB - CA 125 Antigen
Tumor markers facts, information, pictures | Encyclopedia.com articles about Tumor markers
There are two common oncofetal antigens, alphafetoprotein (AFP) and carcinoembryonic antigen (CEA). Carcinoembryonic antigen CA ... Some widely used tumor markers include: AFP, beta-HCG, CA 15-3, CA 19-9, CA 27.29, CA 125, CEA, and PSA. Some tumor markers are ... Some widely used tumor markers include: AFP, beta-HCG, CA 15-3, CA 19-9, CA 27.29, CA 125, CEA, and PSA. Some tumor markers are ... Cancer antigen 15-3 (CA 15-3) CA 15-3 is produced by cells in the breast and increased levels can be associated with breast ...
CA 125 (Tumor Antigen) | Centru Oncologie Severin
The antigen CA 125,with a molecular weight of 220kD glycoprotein is present in the epithelium of the following organs: ovary, ... CA 125 hasa major diagnosis relevance in ovarian serous cancer; it can also be used as a secondary marker in pancreatic cancer ... CA 125 cannot be used for ovarian cancer screening in the general population because of its lack of sensitivity for early stage ... In patients with a family history of breast or ovarian cancer this marker - CA 125should be evaluated every 6 months, along ...
ACCESS Tumor marker - OV monitor (CA 125 Antigen)
TEST : Access Ovarian Cancer Test - OV Monitor (CA 125 antigen) Access OV Monitor aids in the management of ovarian cancer and ... CA 125 antigen levels are most consistently elevated in patients with ovarian cancer. The assay produces first results in 20 ... ACCESS Tumor marker - OV monitor (CA 125 Antigen). BECKMAN - Tumor marker TEST Access Ovarian Cancer Test - OV Monitor CA 125 ... such as transvaginal ultrasonography and a mathematical algorithm that analyzes rates of change of CA 125. The test is ...
Laboratory and diagnostic tumor marker Antigen CA125 Ovarian carcinomas
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CA125 Enzyme Immunoassay. INTENDED USE. For the quantitative determination of the Cancer Antigen CA125 concentration in human ... CA125) is a surface antigen associated with epithelial ovarian cancer. In serum, CA125 is associated with a high molecular ... Enzyme Immunoassay for the Quantitative Determination of Ovarian Cancer Antigen CA125 in Human Serum. FOR IN VITRO DIAGNOSTIC ... CA125 is an antigen present on 80 percent of nonmucinous ovarian carcinomas. It is defined by a monoclonal antibody ( OC125 ) ...
Tumor Markers - BLT System
CA 27.29 - Cancer Antigen. 140293 - Quantitative measurement of Cancer Antigen 27.29. This testing is often done to help manage ... Carbohydrate Antigen 19-9 (CA 19-9). 002261 - The CA 19-9 is used to monitor gastrointestinal, pancreatic, liver and colorectal ... Cancer Antigen (CA) 15-3. 143404 - Quantitative measurement of cancer antigen 15-3. ... Cancer Antigen (CA) 125. 002303 - A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in your blood. A ...
Mouse CA125(Carbohydrate Antigen 125) ELISA Kit - Novosides
Mouse CA125(Carbohydrate Antigen 125) ELISA Kit. Mouse CA125(Carbohydrate Antigen 125) ELISA Kit ... Description: A sandwich CLIA kit for quantitative measurement of Human CA125 (Carbohydrate Antigen 125) in samples from Serum, ... Description: A sandwich ELISA kit for quantitative measurement of Human CA125 (Carbohydrate Antigen 125) in samples from Serum ... CA125 encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that ...
CA-125 test or Cancer Antigen 125 test in Kolhapur - Metropolis Healthcare
In addition, if a woman presents with a mass in the pelvic area; CA 125 test is used to evaluate the mass and order further ... Get accurate and quick report of CA-125 test or Cancer Antigen 125 test in Kolhapur.CA 125 test is used to monitor the ... CA 125 test is used to monitor the treatment of Ovarian Cancer. It is also used to test for recurrence of ovarian cancer. In ... Cancer Antigen 125 (CA-125) is a protein that is found on the surface of ovarian cancer cells. This makes the test useful as ...
Ca 125 Test Or Cancer Antigen 125 Test in titwala - Metropolis Healthcare
CA 125 test is used to monitor the treatment of Ovarian Cancer. It is also used to test for recurrence of ovarian cancer. In ... CA 125 test is used to evaluate the mass and order further tests for management. ... Get accurate and quick report of Ca 125 Test Or Cancer Antigen 125 Test in titwala at your nearest Metropolis lab or your home ... CA125 levels will decline when the doctor puts you on treatment and if the treatment is working. If CA125 levels do not go down ...
SSCA B
CA125) and cancer antigen 15.3 (CA15.3). The results for CA125 in this data release are reported as U/mL. The results for ... Cancer antigen CA125 and CA15.3 - Serum (SSCA_B). Data File: SSCA_B.xpt. First Published: June 2019. Last Revised: NA. ... Cancer antigen 15.3 (mU/mL). English Text: Cancer antigen 15.3 (mU/mL). Target: Females only 20 YEARS - 150 YEARS. Code or ... Human CA125 (single spot, catalog number K151WC) The linearity range for the CA125 was 10,000-0.6 U/ml (low limit of detection ...
Carbohydrate Antigen 125 (CA125) ELISA Kit | Technique alternative | 02021735615 - AniGenetics
James Lanier | Cancer Antigen 125, CA Fibulin-3 Mesomark Osteopontin SOMAmer Panel | Mesothelioma DR
Barbara Herfel | Cancer Antigen 125, CA Fibulin-3 Mesomark Osteopontin SOMAmer Panel | Mesothelioma DR
Barbara Herfel is treating Asbestosis, Clubbed Fingers, Diffuse Pleural Thickening, Laryngeal Cancer, Lung Cancer, Ovarian Cancer, Pericardial Mesothelioma , Pericardial Mesothelioma , Pleural Mesothelioma, Pleuritis, Rounded Atelectasis, Testicular Mesothelioma To request an appointment with Barbara Herfel call us at (435) 200-5326.
How Long Does It Take to Get STD Test Results Back? | Reference.com
Where Can You Take a Test to Determine If You Have PTSD? | Reference.com
Cancer Screens
CA 19-9 Cancer Antigen This test measures the CA 19-9 levels in the blood. It is used as a tumor marker to monitor treatment ... CA 15-3 Cancer Antigen Measures the CA 15-3 levels in the blood - used as a tumor marker to monitor treatment and determine ... and several cancer antigen tests to track treatment response including the CA 125 cancer antigen test to monitor ovarian cancer ... CEA Carcinoembryonic Antigen This test is useful for identifying colon cancer recurrences after tumors have been surgically ...
CarcinoembryonicMonoclonal AntibodyBiomarkers27.29GlycoproteinELISAMouse Carbohydrate AntigenAntibodyProteinCancer Antigen CAHigh CA-125 levelElevated CA 125 levelMUC16TransvaginalLevel of CA-125CarbohydrateAntibodiesDiagnosisAssayCancersLevelsOncofetal antigensEpithelialAscitesTumor Marker CA125ProteinsRecurrent ovarian cancerDetectionBloodScreeningTreated for ovarian cancerReceptorLiverProgesteroneSpecificityOvarian cancer treatmentDetectableMarkersBreastTreatmentSignificantly
Carcinoembryonic8
- Previous studies have indicated that plasma concentrations of chromogranin A (CGA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in healthy individuals, and this can make interpretation of results more complicated. (bibsys.no)
- There are two common oncofetal antigens, alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA). (encyclopedia.com)
- Carcinoembryonic antigen CA 72-4 is a more recently discovered oncofetal antigen just coming into usage. (encyclopedia.com)
- 002139 - Carcinoembryonic antigen (CEA) is a protein found in many types of cells but associated with tumors and the developing fetus. (mcssl.com)
- HealthCheckUSA offers a prostate cancer screening (PSA), and several cancer antigen tests to track treatment response including the CA 125 cancer antigen test to monitor ovarian cancer, and the CEA carcinoembryonic antigen for recurrence of colon cancer. (healthcheckusa.com)
- Carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), cancer antigen 15-3 (CA 15-3), cancer antigen 19-9 (CA 19-9), cancer antigen 27.29 (CA 27.29). (thefreedictionary.com)
- Carcinoembryonic antigen (CEA) is a family of 36 different glycoproteins whose function is believed to be involved in cell adhesion. (thefreedictionary.com)
- A comprehensive screen for 5 cancer markers including Carcinoembryonic Antigen (CEA), Cancer Antigen 19-9, Cancer Antigen 125, Alpha-Fetoprotein (AFP) and Cancer Antigen 15-3 (CA 15-3). (walkinlab.com)
Monoclonal Antibody5
- The pre-coated antibody is Mouse CA125 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. (mybiosource.com)
- The assay system utilizes a monoclonal antibody directed against a distinct antigenic determinant on the intact CA125 molecule is used for solid phase immobilization (on the microtiter wells). (thailabonline.com)
- CA125 is a mucin-like glycoprotein with a molecular weight over 200 kDa, which was first discovered over 30 years ago using the OC125 monoclonal antibody, 1 providing the basis for assays to detect and monitor the progression of epithelial ovarian cancer. (spiedigitallibrary.org)
- Competition assays have demonstrated that monoclonal antibody clone M11 does not compete with monoclonal antibody clone OC125 for binding to the CA 125 antigen (7). (agilent.com)
- CA-125 was initially detected using the murine monoclonal antibody designated OC125. (wikipedia.org)
Biomarkers3
- Lee Biosolutions is the leading supplier of Cancer Antigen 125 (CA-125, MUCIN 16) for ovarian cancer research and biomarkers for manufacturing. (leebio.com)
- Conclusion: CA 125 is not a strong enough predictor to be used as an indicator in lung cancer screening alone, however it may be useful in a panel of complimentary biomarkers. (brocku.ca)
- Future research is needed to explore whether a panel of complimentary biomarkers including CA 125 can improve lung cancer risk prediction. (brocku.ca)
27.293
- 140293 - Quantitative measurement of Cancer Antigen 27.29. (mcssl.com)
- CA 27.29 is a glycoprotein product of the muc-1 gene. (thefreedictionary.com)
- The Cancer Antigen 27.29 blood test is used to monitor patients with breast cancer. (walkinlab.com)
Glycoprotein5
- In serum, CA125 is associated with a high molecular weight glycoprotein. (leebio.com)
- CA 125 Antigen is a heterogonous glycoprotein. (immunotech.cz)
- CA 125 or Muc16 is a glycoprotein member of the mucin family and is present in normal endometrial tissue. (thefreedictionary.com)
- Recognizes a mucin-like glycoprotein larger than 200 kDa, expressing the CA 125 epitope. (agilent.com)
- Prostate specific antigen (PSA) is a glycoprotein produced exclusively in the prostate gland. (directlabs.com)
ELISA9
- Small volumes of CA125 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
- MBS264824 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Carbohydrate Antigen 125 (CA125) ELISA Kit target analytes in biological samples. (mybiosource.com)
- The ELISA analytical biochemical technique of the MBS264824 kit is based on CA125 antibody-CA125 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CA125 antigen targets in samples. (mybiosource.com)
- The ELISA Kit is designed to detect native, not recombinant, CA125. (mybiosource.com)
- The CA125 ELISA test is based on the principle of a solid phase enzyme-linked immunosorbent assay. (thailabonline.com)
- Should the Human Carbohydrate Antigen 125 (CA125) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (novosides.eu)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 125 (CA125) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (novosides.eu)
- Known also as Carbohydrate Antigen 125 elisa. (novosides.eu)
- This antibody detects human CA-125 in the direct ELISA. (angioproteomie.com)
Mouse Carbohydrate Antigen2
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Carbohydrate Antigen 125 (CA125) in serum, plasma, tissue homogenates and other biological fluids. (novosides.eu)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Carbohydrate Antigen 125 (CA125) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
Antibody7
- A rabbit anti-CA125 antibody conjugated to horseradish peroxidase (HRPO) is in the antibody-enzyme conjugate solution. (thailabonline.com)
- When the biofluid sample was passed on the CA-125 antibodies that are immobilized on the gold interdigitated electrodes, the capacitance variation of the sensing circuit was caused due to the antigen - antibody interaction. (lee-research.org)
- However, the capacitance measured during CA-125 antigen - antibody interaction with the microfluidic flow condition (270.34 pF) was lower than static drop condition (296.09 pF) due to the instability of the immobilized antibodies on the sensing surface that was caused by the shear stress on the sensing surface during the microfluidic flow. (lee-research.org)
- In addition, this study demonstrates the use of gold nanoparticles to enhance the sensor signal response and provides experimental results of the capacitance difference during cancer antigen-125 (CA-125) antigen-antibody conjugation at multiple concentrations of CA-125 antigens. (researchwithnj.com)
- The capacitive signal response of antigen-antibody conjugation on interdigitate electrodes has been enhanced by approximately 2.8 times (from 260.80 to 736.33 pF at 20 kHz frequency) in static drop condition and approximately 2.5 times (from 205.85 to 518.48 pF at 20 kHz frequency) in microfluidic flow condition with gold nanoparticle-coating. (researchwithnj.com)
- In Western blotting, the antibody labels multiple antigenic species including the molecular species recognized by monoclonal anti-CA 125, clone OC125 (7). (agilent.com)
- The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied. (wikipedia.org)
Protein11
- A new tumor marker , human epididymis protein 4 (HE4) , may be ordered along with CA-125 to monitor epithelial cell tumors, the most common type of ovarian cancers . (labtestsonline.org)
- Cancer antigen 125 (CA125) is a protein found on most ovarian cancer cells that is secreted into the blood stream and can be measured. (cancer.ca)
- A CA125 test is a blood test that measures the amount of CA125 protein in the blood. (cancer.ca)
- Cancer antigen 125 (CA-125) is a protein found on the surface of many ovarian cancer cells. (northshore.org)
- A CA-125 test measures the amount of this protein in the blood. (northshore.org)
- A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence ( Δ n ) to promote sensitivity in detecting biomolecules. (spiedigitallibrary.org)
- The aim of this study was to analyze the diagnostic value of the tumor markers, including risk of malignancy index (RMI), human epididymis protein 4 (HE4), cancer antigen125 (CA125), and risk of ovarian malignancy algorithm (ROMA) in ovarian mass. (kowsarpub.com)
- these markers include human epididymis protein 4 (HE4), risk of malignancy index (RMI), cancer antigen125 (CA125), and risk of ovarian malignancy algorithm (ROMA) ( 8 ). (kowsarpub.com)
- CA 19-9 is a protein found on the surface of some cancer cells. (requestatest.com)
- Cancer antigen 125 (CA-125) is a protein found in ovarian cancer cells. (walkinlab.com)
- CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. (wikipedia.org)
Cancer Antigen CA3
- The Cancer Antigen (CA) 19-9 test is often used to aid in the diagnosis of Pancreatic Cancer . (requestatest.com)
- The Female Ultimate Anti-Aging Panel is our Ultimate Anti-Aging Panel, with the addition of Progesterone and the Cancer Antigen (CA) 125 test. (privatemdlabs.com)
- High levels of cancer antigen (CA)-125 were detected in 6 of 15 patients. (cancer.gov)
High CA-125 level2
- Often the high CA-125 level is found many months before the return of cancer can be found in another way. (northshore.org)
- For example, a woman with ovarian cancer may have a high CA 125 level when she is first diagnosed. (healthwise.net)
Elevated CA 125 level2
- In addition, serial serum CA 125 levels were determined in 30 women with an initially elevated CA 125 level (30 U/mL or more) and 30 women with a CA 125 level less than 30 U/mL. (nih.gov)
- It was found that an elevated CA 125 level was associated with a higher risk of lung cancer in individuals who smoked. (brocku.ca)
MUC162
- MUC16 (CA-125) has been shown to play a role in advancing tumorigenesis and tumor proliferation by several different mechanisms. (wikipedia.org)
- The region (residues 296-359) consisting of 64 amino acids at the N-terminus of cell surface mesothelin has been experimentally established as the functional binding domain (named IAB) for MUC16/CA125. (wikipedia.org)
Transvaginal13
- CA-125 is sometimes used along with transvaginal ultrasound to test and monitor women who have a high risk for ovarian cancer but who do not yet have the disease. (labtestsonline.org)
- Sometimes a CA-125 test may be ordered along with a transvaginal ultrasound to help investigate a lump in woman's lower abdominal area (pelvic mass. (labtestsonline.org)
- Some healthcare providers may order a CA-125 test and a transvaginal ultrasound at regular intervals when a woman is at high risk of developing ovarian cancer. (labtestsonline.org)
- If you have a high risk for ovarian cancer, your doctor may recommend that you have the CA-125 blood test along with a transvaginal ultrasound on a regular basis. (webmd.com)
- But some doctors may recommend the CA-125 test and a transvaginal ultrasound for women who have a very high risk of ovarian cancer, such as those with BRCA gene changes. (northshore.org)
- In patients with a family history of breast or ovarian cancer this marker - CA 125should be evaluated every 6 months, along with transvaginal ultrasound performed every year for early detection of ovarian cancer. (clinicaoncologieseverin.ro)
- Minor complications with screening: 58.3 cases per 10,000 women screened with CA-125 and 3.3 cases per 10,000 women screened with transvaginal sonogram (TVS). (oncolink.org)
- Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality. (nih.gov)
- Intervention The intervention group was offered annual screening with CA-125 for 6 years and transvaginal ultrasound for 4 years. (nih.gov)
- The usual care group was not offered annual screening with CA-125 for 6 years or transvaginal ultrasound but received their usual medical care. (nih.gov)
- Among women in the general US population, simultaneous screening with CA-125 and transvaginal ultrasound compared with usual care did not reduce ovarian cancer mortality. (nih.gov)
- Annual screening with CA-125 and transvaginal ultrasonography did not reduce ovarian cancer incidence or mortality. (nih.gov)
- For patients with hereditary nonpolyposis colorectal cancer syndrome or hereditary breast and ovarian cancer syndrome who choose not to undergo prophylactic bilateral salpingo-oophorectomy, the National Comprehensive Cancer Network recommends transvaginal ultrasonography and CA 125 measurement every six months during days 1 through 10 of the menstrual cycle. (aafp.org)
Level of CA-1253
- A very high level of CA-125 is something the doctor will want to look into, but it doesn't always mean you have ovarian cancer. (webmd.com)
- If the level of CA-125 is going down, it usually means that the treatment is working. (northshore.org)
- Women who continued their first trimester of pregnancy showed a significantly higher number of previous abortions and progesterone level (43.12±20.85 vs. 19.26±11.8, P = 0.01) and lower level of CA 125 (34.9±11.053 vs. 61.9±19.21, P = 0.022) when compared with those who aborted. (ekb.eg)
Carbohydrate2
- CA 19-9 is a carbohydrate antigen used for post-therapeutic monitoring of patients with gastrointestinal, pancreatic, liver, and colorectal cancer. (thefreedictionary.com)
- Since its discovery in 1981 by Bast and colleagues ( 3 ), carbohydrate antigen 125 (CA125) still remains the gold-standard serum biomarker for ovarian cancer. (aacrjournals.org)
Antibodies3
- Include markers defined by both monoclonal antibodies and polyclonal antisera, often the so called oncofetal antigens. (thailabonline.com)
- The test sample is allowed to react simultaneously with the two antibodies, resulting in the CA125 molecules being sandwiched between the solid phase and enzyme-linked antibodies. (thailabonline.com)
- These tests typically identify "antigens," or abnormal substances in the blood that cause the immune system to produce antibodies against it. (healthcheckusa.com)
Diagnosis3
- CA 125 determination is used mainly for diagnosis and monitoring of ovarian cancer. (immunotech.cz)
- If you are not being treated for ovarian cancer, and your results show high CA-125 levels, your health care provider will probably order more tests to help make a diagnosis. (medlineplus.gov)
- CA125 is approved for both monitoring treatment with chemotherapy and differential diagnosis of patients presenting with a pelvic mass. (aacrjournals.org)
Assay2
- Easy, convenient and time-saving method to assay CA-125. (biovision.com)
- The QC pool for this assay was prepared by pooling a small volume (5 ul/ sample) from over 2000 serum samples which had shown well measurable levels of CA125 in a prior study using the MSD platform. (cdc.gov)
Cancers6
- That's because not all ovarian cancers cause CA-125 levels to rise. (webmd.com)
- This test is not recommended as a screening test for ovarian cancer because CA125 can be normal in many women with early stage ovarian cancer and it may be higher than normal in non-cancerous (benign) conditions and other cancers. (cancer.ca)
- An increased CA125 value can occur in both cancers and non-cancerous conditions. (cancer.ca)
- A CA 125 test may be used to monitor certain cancers during and after treatment. (mcssl.com)
- Measures the CA 15-3 levels in the blood - used as a tumor marker to monitor treatment and determine recurrence of metastatic breast cancer, though it may be used to track certain other cancers of the lung, pancreas, liver, colon or ovaries. (healthcheckusa.com)
- CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other conditions that are benign. (wikipedia.org)
Levels33
- If CA-125 levels fall during therapy, this generally indicates that the cancer is responding to treatment. (labtestsonline.org)
- If CA-125 levels rise or stay the same, then the cancer may not be responding to therapy. (labtestsonline.org)
- High CA-125 levels after treatment is complete may indicate that the cancer has come back. (labtestsonline.org)
- 80% or more of women with ovarian cancer have high levels of CA-125. (webmd.com)
- And you also can have higher-than-normal levels of CA-125 without having ovarian cancer . (webmd.com)
- Also, healthy, normal tissue in the cells of the ovaries, pancreas , breast , and lining of the chest and stomach make and release low levels of CA-125. (webmd.com)
- If you are being treated for ovarian cancer and your CA-125 levels go down during this time, it usually means your treatment is working. (webmd.com)
- Very high levels of CA-125 after you finish ovarian cancer treatment could be a sign that the cancer has returned. (webmd.com)
- High levels of CA-125 are a strong sign that the cancer started in the ovary. (northshore.org)
- But other types of cancer can increase CA-125 levels too. (northshore.org)
- Published studies have indicated that elevated serum CA125 levels can be found in individuals with serious endometroid, clear-cell and undifferentiated ovarian carcinoma. (leebio.com)
- Levels of specificity suitable for screening asymptomatic postmenopausal women can be achieved using tumor-associated antigens measured serially or in combination. (nih.gov)
- CA125 levels will decline when the doctor puts you on treatment and if the treatment is working. (metropolisindia.com)
- If CA125 levels do not go down during therapy, it means your treatment is not adequate. (metropolisindia.com)
- Sometimes CA125 levels are higher if a woman has a pelvic mass and if she may develop ovarian cancer in the future. (metropolisindia.com)
- Sera from residual specimens from NHANES 2001-2002 participants were tested for levels of cancer antigen 125 (CA125) and cancer antigen 15.3 (CA15.3). (cdc.gov)
- Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort. (cdc.gov)
- This test measures the CA 19-9 levels in the blood. (healthcheckusa.com)
- Results: Women with threatened abortion showed a significantly higher number of previous abortions and CA 125 levels (47.82±30.93 vs. 30.08±19.21, P =0.36) and lower rate of pregnancy continuation (76 vs. 90%, P = 0.044) when compared to controls. (ekb.eg)
- Screening with TVU alone or with multimodal screening with CA-125 levels, assessed using the ROCA, combined with TVU in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) did not show a mortality benefit of screening with either approach based on a predetermined primary endpoint among women undergoing 7 to 11 screens and a median of 11.1 years of follow-up. (oncolink.org)
- Absence of detectable levels of CA 125 does not rule out the presence of tumor. (thefreedictionary.com)
- Because not every person with pancreatic cancer will show elevated levels of CA 19-9, this test will not always be an effective tumor marker. (requestatest.com)
- CA-125 levels are high in many women with ovarian cancer . (medlineplus.gov)
- Because high CA-125 levels can be a sign of other conditions besides ovarian cancer, this test is not used to screen women at low risk for the disease. (medlineplus.gov)
- If testing shows your CA-125 levels have gone down, it usually means the cancer is responding to treatment. (medlineplus.gov)
- If you have finished your treatment for ovarian cancer, high CA-125 levels may mean your cancer has come back. (medlineplus.gov)
- If you are not being treated for ovarian cancer and your results show high CA-125 levels, it can be a sign of cancer. (medlineplus.gov)
- The Men's Expanded Cancer Panel is a panel of blood tests that includes the CEA and the PSA test to detect antigens and read blood hormone levels. (healthtestingcenters.com)
- After treatment, her levels of CA 125 should fall. (healthwise.net)
- 1985) Predictive value of CA 125 antigen levels in second-look procedures for ovarian cancer. (springer.com)
- The standard clinical cutoff value for CA125 is 35 U/mL, although serum levels have been shown to fluctuate depending on race, menstrual cycle time point, and presence of non-ovarian cancer pathologies ( 4-7 ). (aacrjournals.org)
- Testing of CA-125 blood levels has been proposed as useful in treating ovarian cancer. (wikipedia.org)
- While the test can give useful information for women already known to have ovarian cancer, CA-125 testing has not been found useful as a screening method because of the uncertain correlation between CA-125 levels and cancer. (wikipedia.org)
Oncofetal antigens1
- The oncofetal antigens are so named because they are normally produced during embryonic development and decrease soon after birth. (encyclopedia.com)
Epithelial3
- Cancer Antigen 125 (CA125) is a surface antigen associated with epithelial ovarian cancer. (leebio.com)
- To date, CA125 is the most sensitive marker for residual epithelial ovarian cancer. (thailabonline.com)
- Multifocal staining for neuron specific enolase (NSE) and mesothelin and focal high molecular weight (HMW)+low molecular weight cytokeratin (CK), epithelial membrane antigen (EMA), synaptophysin (SYNP), WT1 positivity was detected (Figure 1, 2). (thefreelibrary.com)
Ascites1
- CA 125 antigen derived from ascites fluid. (agilent.com)
Tumor Marker CA1251
- The usage of tumor marker CA125 alone is associated with serious limitations like low sensitivity for early or stage I disease and lack of specificity especially in pre-menopausal women. (intjcancermanag.com)
Proteins1
- The CA-125 test looks for certain proteins in your blood . (webmd.com)
Recurrent ovarian cancer2
- To investigate the benefit of early chemotherapy for recurrent ovarian cancer based on a raised CA125 (a serum marker) level alone, versus chemotherapy based on conventional clinical indicators. (isrctn.com)
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16(ecto) directed chimeric antigen receptors for recurrent ovarian cancer. (springer.com)
Detection5
- The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 100 U/ml-1.56 U/ml in biological research samples containing CA125, with an estimated sensitivity of 0.5 U/ml. (mybiosource.com)
- The determination of CA 19-9 cannot be used for the early detection of pancreatic carcinoma. (mcssl.com)
- The linearity range for the CA125 was 10,000-0.6 U/ml (low limit of detection (LLD) 0.286 U/ml). (cdc.gov)
- Women were enrolled in the Gilda Radner Ovarian Cancer Detection program at Cedars-Sinai Medical Center, Los Angeles, California from July 1, 1991, to July 1, 1993. (nih.gov)
- The experimental results also provide evidence of disease-specific detection of CA-125 antigen at multiple concentrations with the increase in capacitive signal response proportional to the concentration of the CA-125 antigens. (researchwithnj.com)
Blood12
- The test for CA-125 may also be done on body fluids (other than blood) taken from the chest or stomach area. (northshore.org)
- The CA-125 test quantifies and is a measure of the amount of CA125 in the blood. (metropolisindia.com)
- What is a CA-125 blood test? (medlineplus.gov)
- A CA-125 blood test is most often done on women already diagnosed with ovarian cancer. (medlineplus.gov)
- Why do I need a CA-125 blood test? (medlineplus.gov)
- You may need a CA-125 blood test if you are currently being treated for ovarian cancer. (medlineplus.gov)
- You don't need any special preparations for a CA-125 blood test. (medlineplus.gov)
- Is there anything else I need to know about a CA-125 blood test? (medlineplus.gov)
- A test for a tumor marker called HE4 may be done along with a CA-125 blood test. (medlineplus.gov)
- Get cancer blood testing labs and get same day testing from FDA approved labs near Santa Maria CA. (healthtestingcenters.com)
- A CA-125 blood test to measure the amount of cancer-antigen 125 in your blood. (familydoctor.org)
- Walk-In Lab offers several cancer blood tests such as the Cancer Screening Panel, Women, the CA 15-3, and the CA 125. (walkinlab.com)
Screening10
- Because CA-125 can be high in many normal or benign conditions, such as pregnancy , menstruation, endometriosis , and pelvic inflammatory disease , it is not useful or recommended as a screening test for the general population. (labtestsonline.org)
- Experts do not recommend using the CA-125 test as a screening test for ovarian cancer because it often has false-positive results that can lead to unneeded surgery. (northshore.org)
- Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and TAG 72.3. (nih.gov)
- To assess different strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens, including concomitant measurement of multiple tumor markers and serial measurement of CA 125. (nih.gov)
- A combination of CA 125, CA 15-3, and TAG 72.3 was evaluated in serum samples from 217 of 1010 apparently healthy postmenopausal women who had participated in a study of screening for ovarian cancer and who had a serum CA 125 level of 20 U/mL or greater. (nih.gov)
- CA 125 cannot be used for ovarian cancer screening in the general population because of its lack of sensitivity for early stage disease. (clinicaoncologieseverin.ro)
- There is solid evidence to indicate that screening women aged 55 to 74 years at average risk of developing ovarian cancer with the serum marker CA-125 (at a fixed threshold for a positive result of 35 U/mL) annually for 6 years and TVU for 4 years does not result in a decrease in ovarian cancer mortality, after a median follow-up of 14.7 years. (oncolink.org)
- While a CA 19-9 test can be used to differentiate types of cancer or monitor response to treatment, it is not sensitive enough to be used as an initial screening by itself. (requestatest.com)
- If you answered yes to any of them, you would be wise to look into cancer screening near Santa Maria, CA. (healthtestingcenters.com)
- Why is regular cancer screening near Santa Maria, CA so important? (healthtestingcenters.com)
Treated for ovarian cancer1
- High values of CA-125 in a woman who has been treated for ovarian cancer may mean that the cancer has returned. (northshore.org)
Receptor4
- Recently, chimeric antigen receptor (CAR) T cell therapy has shown promising results in hematological tumors and current research is going on in various solid tumors like ovarian cancer. (springer.com)
- Sadelain M, Brentjens R, Rivière I. The basic principles of chimeric antigen receptor design. (springer.com)
- Chmielewski M, Hombach AA, Abken H. Antigen-specific T-cell activation independently of the MHC: chimeric antigen receptor-redirected T cells. (springer.com)
- Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition. (springer.com)
Liver1
- 002261 - The CA 19-9 is used to monitor gastrointestinal, pancreatic, liver and colorectal malignancies. (mcssl.com)
Progesterone4
- Cancer antigen 125 (CA-125) and serum progesterone as predictors of fate of threatened abortion: Case control study', Evidence Based Women's Health Journal , 7(4), pp. 177-183. (ekb.eg)
- Objective: To investigate the predictive value of serum progesterone and CA-125 regarding pregnancy continuation in women with threatened abortion. (ekb.eg)
- Group II included 100 women with normal asymptomatic pregnancy.CA 125 and serum progesterone were measured in all women. (ekb.eg)
- Conclusion: CA125 and progesterone are good predictors for the outcome of 1st trimester of pregnancy in both normal women and those with threatened abortion. (ekb.eg)
Specificity4
- The specificity of CA 125 at upper limits of 30 and 50 U/mL was increased from 97.0 and 99.5%, respectively, to 98.9 and 99.9% when a positive test was defined as an elevated serum CA 125 level in combination with either a CA 15-3 greater than 30 U/mL or a TAG 72.3 greater than 10 U/mL. (nih.gov)
- Serial determinations of serum CA125 as well as pelvic examination increase the test specificity. (thailabonline.com)
- The evaluation of the area under the curve (AUC) for isolated CA-125 and HE4, and for ROMA and RMI-II, showed a better specificity of HE4 and RMI-II in premenopausal women. (nih.gov)
- As such, a major limitation of CA125 is that it displays poor specificity for ovarian cancer overall ( 8-10 ). (aacrjournals.org)
Ovarian cancer treatment1
- The CA-125 test may be ordered before a woman starts ovarian cancer treatment as a baseline to compare against future measurements. (labtestsonline.org)
Detectable1
- The minimum detectable concentration of CA-125 is less than 0.6 U/ml. (biovision.com)
Markers3
- One hundred patients with ovarian masses were assessed for the tumor markers ROMA, HE4, RMI, and CA125. (kowsarpub.com)
- The results based on the AUC markers of CA125, HE4, RMI, and ROMA revealed that the accuracy trend of ROMA was higher than that of CA125, HE4, and RMI in all the patients and each group of pre- and post-menopausal patients. (kowsarpub.com)
- The markers identified through our integrated -omics approach performed similarly to the clinically approved markers CA125 and HE4. (aacrjournals.org)
Breast1
- CA 15-3 monitors patients for recurrence or metastasis of breast carcinoma. (thefreedictionary.com)
Treatment10
- Cancer Antigen 125 (CA-125) is a tumor marker primarily used to monitor therapy during treatment for ovarian cancer . (labtestsonline.org)
- CA-125 is also used to detect whether cancer has come back after treatment is complete. (labtestsonline.org)
- Your doctor may order a CA-125 test if you're about to start treatment for ovarian cancer . (webmd.com)
- A decrease in the CA125 level during treatment usually means that the cancer is responding to treatment. (cancer.ca)
- If the CA125 level stays the same or rises during treatment, it may mean that the cancer is not responding to treatment. (cancer.ca)
- A high CA125 level after treatment is complete may mean that the cancer has come back (recurred). (cancer.ca)
- Most often, the CA-125 test is used to check how well treatment for ovarian cancer is working or to see if ovarian cancer has returned. (northshore.org)
- Following a raised CA125 result patients are randomised to receive either delayed treatment until patient shows clinical signs of relapse or immediate treatment which must start within 4 weeks. (isrctn.com)
- Serum CA125 concentration may be useful in monitoring treatment and distinguishing between good response to treatment and progressive malignant disease with poor therapeutic response. (thailabonline.com)
- CA 125 test is used to monitor the treatment of Ovarian Cancer. (metropolisindia.com)
Significantly2
- In a woman with a pelvic mass, and in a woman with a high risk for developing ovarian cancer, a significantly elevated CA-125 is a concern but does not necessarily indicate ovarian cancer. (labtestsonline.org)
- Results: The study demonstrated that CA 125 is significantly and independently associated with lung cancer and that CA 125 is associated with early-stage lung cancer. (brocku.ca)