A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Measurement of rate of settling of erythrocytes in anticoagulated blood.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.
An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.
A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease outcome.
Infections by bacteria, general or unspecified.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.
Disease having a short and relatively severe course.
A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.
Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
An abnormal elevation of body temperature, usually as a result of a pathologic process.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
An infant during the first month after birth.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Elements of limited time intervals, contributing to particular results or situations.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Substances that reduce or suppress INFLAMMATION.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Antibodies produced by a single clone of cells.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Therapy with two or more separate preparations given for a combined effect.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The sum of the weight of all the atoms in a molecule.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/7727)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (2/7727)

BACKGROUND: In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability. METHODS AND RESULTS: We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (>3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP <3 mg/L but 69% of those with elevated CRP (P<0.001) were readmitted because of recurrence of instability or new myocardial infarction. New phases of instability occurred in 13% of patients in the lower tertile of CRP (/=8.7 mg/L, P<0.001). The prognostic value of SAA was similar to that of CRP; that of fibrinogen was not significant. Chlamydia pneumoniae but not Helicobacter pylori antibody titers significantly correlated with CRP plasma levels. CONCLUSIONS: In unstable angina, CRP may remain elevated for at >/=3 months after the waning of symptoms and is associated with recurrent instability. Elevation of acute-phase reactants in unstable angina could represent a hallmark of subclinical persistent instability or of susceptibility to recurrent instability and, at least in some patients, could be related to chronic Chlamydia pneumoniae infection.  (+info)

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. (3/7727)

Criteria of the systemic inflammatory response syndrome (SIRS) are known to include patients without systemic inflammation. Our aim was to explore additional markers of inflammation that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1beta, tumour necrosis factor-alpha and C-reactive protein were determined, and severity of inflammation was evaluated by systemic inflammation composite score based on CD11b expression, C-reactive protein and cytokine levels. Levels of CD11b expression, C-reactive protein and interleukin-6 were higher in sepsis patients than in SIRS patients who met two criteria (SIRS2 group) or three criteria of SIRS (SIRS3 group). The systemic inflammation composite score of SIRS2 patients (median 1.5; range 0-8, n=56) was lower than that of SIRS3 patients (3.5; range 0-9, n=14, P=0.013) and that of sepsis patients (5.0; range 3-10, n=19, P<0.001). The systemic inflammation composite score was 0 in 13/94 patients. In 81 patients in whom systemic inflammation composite scores exceeded 1, interleukin-6 was increased in 64 (79.0%), C-reactive protein in 59 (72.8%) and CD11b in 50 (61.7%). None of these markers, when used alone, identified all patients but at least one marker was positive in each patient. Quantifying phagocyte CD11b expression and serum interleukin-6 and C-reactive protein concurrently provides a means to discriminate SIRS patients with systemic inflammation from patients without systemic inflammation.  (+info)

Socioeconomic status and determinants of hemostatic function in healthy women. (4/7727)

Hemostatic factors are reported to be associated with coronary heart disease (CHD). Socioeconomic status (SES) is 1 of the determinants of the hemostatic profile, but the factors underlying this association are not well known. Our aim was to examine determinants of the socioeconomic differences in hemostatic profile. Between 1991 and 1994, we studied 300 healthy women, aged 30 to 65 years, who were representative of women living in the greater Stockholm area. Fibrinogen, factor VII mass concentration (FVII:Ag), activated factor VII (FVIIa), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1) were measured. Educational attainment was used as a measure of SES. Low educational level and an unfavorable hemostatic profile were both associated with older age, unhealthful life style, psychosocial stress, atherogenic biochemical factors, and hypertension. Levels of hemostatic factors increased with lower educational attainment. Independently of age, the differences between the lowest (mandatory) and highest (college/university) education in FVII:Ag levels were 41 microg/L (95% confidence interval [CI], 15 to 66 microg/L, P=0.001), 0.26 g/L (95% CI, 0.10 to 0.42 g/L, P=0.001) in fibrinogen levels, and 0.11 U/mL (95% CI, 0.09 to 0.12 U/mL, P=0.03) in levels of vWF. The corresponding differences in FVIIa and PAI-1 were not statistically significant. With further adjustment for menopausal status, family history of CHD, marital status, psychosocial stress, lifestyle patterns, biochemical factors, and hypertension, statistically significant differences between mandatory and college/university education were observed in FVII:Ag (difference=34 microg/L; 95% CI, 2 to 65 microg/L, P=0.05) but not in fibrinogen (difference=0.03 g/L; 95% CI, -0.13 to 0.19 g/L, P=0.92) or in vWF (difference=0.06 U/mL; 95% CI, -0.10 to 0.22 U/mL, P=0.45). An educational gradient was most consistent and statistically significant for FVII:Ag, fibrinogen, and vWF. Age, psychosocial stress, unhealthful life style, atherogenic biochemical factors, and hypertension mediated the association of low educational level with elevated levels of fibrinogen and vWF. Psychosocial stress and unhealthful life style were the most important contributing factors. There was an independent association between education and FVII:Ag, which could not be explained by any of these factors.  (+info)

Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study. (5/7727)

BACKGROUND: Chlamydia pneumoniae commonly causes respiratory infection, is vasotropic, causes atherosclerosis in animal models, and has been found in human atheromas. Whether it plays a causal role in clinical coronary artery disease (CAD) and is amenable to antibiotic therapy is uncertain. METHODS AND RESULTS: CAD patients (n=302) who had a seropositive reaction to C pneumoniae (IgG titers >/=1:16) were randomized to receive placebo or azithromycin, 500 mg/d for 3 days, then 500 mg/wk for 3 months. Circulating markers of inflammation (C-reactive protein [CRP], interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha), C pneumoniae antibody titers, and cardiovascular events were assessed at 3 and 6 months. Treatment groups were balanced, with age averaging 64 (SD=10) years; 89% of the patients were male. Azithromycin reduced a global rank sum score of the 4 inflammatory markers at 6 (but not 3) months (P=0. 011) as well as the mean global rank sum change score: 531 (SD=201) for active drug and 587 (SD=190) for placebo (P=0.027). Specifically, change-score ranks were significantly lower for CRP (P=0.011) and IL-6 (P=0.043). Antibody titers were unchanged, and number of clinical cardiovascular events at 6 months did not differ by therapy (9 for active drug, 7 for placebo). Azithromycin decreased infections requiring antibiotics (1 versus 12 at 3 months, P=0.002) but caused more mild, primarily gastrointestinal, adverse effects (36 versus 17, P=0.003). CONCLUSIONS: In CAD patients positive for C pneumoniae antibodies, global tests of 4 markers of inflammation improved at 6 months with azithromycin. However, unlike another smaller study, no differences in antibody titers and clinical events were observed. Longer-term and larger studies of antichlamydial therapy are indicated.  (+info)

Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. (6/7727)

BACKGROUND: The benefits of near-patient, point-of-care tests have not been fully examined. We have assessed the clinical, organizational, and economic outcomes of implementing a near-patient test for C-reactive protein (CRP) in general practice. METHODS: In a randomized crossover trial during intervention periods, general practitioners (GPs) were allowed to measure CRP within 3 min, using NycoCard(R) CRP. During control periods, they had to mail blood samples for CRP measurements to the hospital laboratory and received test results 24-48 h later. Twenty-nine general practice clinics participated (64 GPs), and 1853 patients were included in the study. Results were evaluated at both the level of participating GPs and the level of included patients. RESULTS: For participating GPs, the overall use of erythrocyte sedimentation rates (ESRs) decreased by 8% (95% confidence interval, 1-14%) during intervention periods, and the number of blood samples mailed to the hospital laboratory decreased by 6% (1-10%). No reduction in the prescription of antibiotics was seen. The proportion of study patients having a follow-up telephone consultation was reduced from 63% to 53% (P = 0. 0001), and patients with CRP concentrations >50 mg/L had their antibiotic treatments started earlier when CRP was measured in general practices (P = 0.0161). CONCLUSION: The implementation of the near-patient CRP test was cost-effective mainly on the basis of a reduction in the use of services from the hospital laboratory by GPs. If the implementation is followed by education and clinical guidelines, opportunities exist for additional reduction in the use of ESR and for a more appropriate use of antibiotics.  (+info)

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (7/7727)

BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection.  (+info)

Leptin elimination in hyperleptinaemic peritoneal dialysis patients. (8/7727)

BACKGROUND: Elevated plasma concentrations of leptin, a hormone thought to regulate body composition by influencing food intake/metabolic rate, are prevalent in renal failure patients. The mechanism for these increases is not known, but evidence suggests that simple accumulation due to decreased elimination is insufficient explanation. METHODS: We studied the incidence of hyperleptinaemia in 28 end-stage renal disease patients treated with continuous ambulatory peritoneal dialysis (CAPD), compared with body-mass-index-and sex-matched controls. Results were separated by gender because women have higher leptin concentrations than men. Excretion of leptin and other substances in dialysis fluid was also studied. RESULTS: Hyperleptinaemia was prevalent in women CAPD subjects, but not in men. Plasma leptin concentrations correlated strongly with the daily excretion of leptin in dialysis fluid. Clearance of leptin in dialysis fluid was greater in men than women CAPD subjects. Single regression analysis found that fasting insulin, glucose content of dialysis fluid, plasma albumin, C-reactive protein, erythropoietin dose, urinary creatinine clearance and plasma beta2-microglobulin were not determinants of plasma leptin concentrations. Stepwise forward multiple regression, examining the dependence of plasma leptin on body mass index, renal creatinine clearance, plasma albumin, daily dialysis fluid glucose load, daily leptin in dialysis fluid, erythropoietin dose and plasma C-reactive protein found only erythropoietin dose as a consistent negative predictor of plasma leptin concentrations. CONCLUSIONS: The results suggest that hyperleptinaemia of CAPD was due to predisposing loss of renal elimination capacity combined with increased production due to obesity (more prevalent in women subjects of this study) and potentially female gender.  (+info)

TY - JOUR. T1 - Pre‐pregnancy body mass index is associated with dietary inflammatory index and C‐reactive protein concentrations during pregnancy. AU - Shin, Dayeon. AU - Hur, Junguk. AU - Cho, Eun Hee. AU - Chung, Hae Kyung. AU - Shivappa, Nitin. AU - Wirth, Michael D.. AU - Hébert, James R.. AU - Lee, Kyung Won. PY - 2017/4/1. Y1 - 2017/4/1. N2 - There have been a limited number of studies examining the association between prepregnancy body mass index (BMI) and dietary inflammation during pregnancy. Our aim is to examine the association between pre‐pregnancy BMI and the Dietary Inflammatory Index (DII)™ and C‐reactive protein (CRP) concentrations during pregnancy. The study included 631 pregnant American women from the National Health and Nutrition Examination Survey (NHANES) crosssectional examinations from 2003 to 2012. Pre‐pregnancy BMI was calculated based on self‐reported pre‐pregnancy weight and measured height. The cut‐offs of ,18.5 (underweight), 18.5-24.9 (normal), ...
Serial study of C reactive protein concentrations in cardiac allograft recipients.: C reactive protein (CRP) concentrations were measured serially in 38 patient
Using a prospective cohort study of 2,910 Danish women with invasive breast cancer, we have demonstrated that elevated CRP levels at the time of diagnosis of breast cancer were associated with reduced overall and disease-free survival and with increased risk of death from breast cancer. These are novel observations.. Mechanistically, three components might explain the observed association between elevated CRP levels and poor breast cancer prognosis. First, tumour cell behavior: plasma CRP levels may reflect the aggressiveness of the tumour, that is, plasma CRP levels might sum up some prognostic information of well-known tumour characteristics, such as tumour stage and grade. In the present study, elevated CRP levels were indeed associated with larger tumour size, presence of distant metastases, and lower tumour grade (although CRP was not linearly associated with tumour grade), and these prognostic factors were associated with poor prognosis. Second, adjacent inflammation: plasma CRP levels ...
Background. Cardiac Magnetic Resonance Imaging (CMR) can identify myocardial damage due to embolization after percutaneous coronary interventions (PCI). Late Gadolinium Enhancement (LGE) can non-invasively detect myocardial fibrosis however the association of High sensitive C-reactive protein (HS-CRP) or Neopterin levels with myocardial damage in PCI is currently unknown.. Methods. Patients admitted with potential PCI were enrolled. LGE CMR scan was performed 24hours pre- and 24 hours post-PCI. Fourty five patients were enrolled, 61±12 yrs old, 33(73%) male. CMR performed pre PCI failed to show LGE in the area of the target vessel. TnI were not elevated at baseline. New LGE areas in the 2nd CMR scan were classified in distal (, 10 mm downstream from the stent) or adjacent (close to the stent). Troponin I was assessed at baseline and at 12 and 24 hours after PCI.. Results. In 35 out of 45 pts, baseline levels of HS-CRP and neopterin were measured.Troponin I elevation occurred in 26 (58%) ...
Objective: To examine levels of C reactive protein in users of anabolic androgenic steroids (AAS) compared with age matched control groups consisting of AAS using (but abstinent)/resistance trained and non-drug using/sedentary controls.. Method: Subjects included AAS using bodybuilders (n = 10); bodybuilders who denied AAS use (n = 10); sedentary controls (n = 8). Venous blood was sampled, from which serum concentrations of C reactive protein, male sex hormones, and cardiac troponin T were determined.. Results: A significantly altered hormonal profile in the AAS using group provided indirect confirmation of AAS use. C reactive protein concentrations were significantly (p,0.05) higher in the AAS using bodybuilders. There was no relation between C reactive protein and cardiac troponin T.. Conclusion: AAS using bodybuilders had significantly higher C reactive protein concentrations, indicating a greater propensity to develop peripheral arterial disease.. ...
TY - JOUR. T1 - Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents. AU - Hammad, Maha M. AU - Abu-Farha, Mohamed. AU - Al-Taiar, Abdullah. AU - Alam-Eldin, Nada. AU - Al-Sabah, Reem. AU - Shaban, Lemia. AU - Al-Mulla, Fahd. AU - Abubaker, Jehad. AU - Rahman, Abdur. PY - 2020/4/14. Y1 - 2020/4/14. N2 - Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11-14 years) were randomly selected from middle schools in Kuwait. Obesity ...
Type 1 diabetes is now accepted to be a chronic immunoinflammatory disorder. Because it is a disease of inflammation-both of the innate and adaptive immune systems-it is perhaps not surprising that elevated CRP levels were found. It is important to note that the elevated CRP levels were found before elevated glucose levels, so that this marker of inflammation is not related to hyperglycemia. This observation is impossible to study in people who already have type 1 diabetes.. CRP was more likely to be positive in children progressing to type 1 diabetes. CRP production is stimulated by inflammatory cytokines such as interleukin (IL)-6. Higher levels of IL-6 have been described in young adults with type 1 diabetes compared with control subjects (19). Mendall et al. (20) showed that elevated CRP levels were positively associated with elevated serum levels of the IL-6 cytokine.. Children with either one or two or more positive IAs were more likely to have elevated CRP concentrations than IA− ...
The results of the present study demonstrate for the first time that elevated CRP levels are associated with a profound impairment in systemic endothelial vascular reactivity in patients with coronary artery disease. The blunted systemic endothelial vasodilator function related to elevated plasma CRP levels is independent of classic risk factors for coronary artery disease. Most importantly, normalization of CRP levels over time is associated with a significant improvement in endothelium-dependent FBF responses. These findings support the concept that alterations in endothelial cell function may provide a link between systemic inflammation and ischemic coronary events.. It is well established that atherosclerosis impairs endothelial vasodilator function in both the coronary18 and the forearm circulation. Moreover, chronic risk factors for coronary artery disease have been shown to adversely affect endothelium-dependent blood flow responses in the human forearm circulation.19 20 However, the ...
TY - JOUR. T1 - Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting. AU - Hong, Young Joon. AU - Jeong, Myung Ho. AU - Lim, Sang Yeob. AU - Lee, Sang Rok. AU - Hong, Seo Na. AU - Kim, Kye Hun. AU - Sohn, Il Suk. AU - Park, Hyung Wook. AU - Kim, Ju Han. AU - Kim, Weon. AU - Ahn, Youngkeun. AU - Cho, Jeong Gwan. AU - Park, Jong Chun. AU - Kang, Jung Chaee. PY - 2006/8/1. Y1 - 2006/8/1. N2 - Although various predictors relating to in-stent restenosis (ISR) have been demonstrated, the relation between the parameters of intravascular ultrasound and inflammatory markers and ISR has not been reported. This study included 120 patients who underwent stent implantation for angiographically significant stenosis. Patients were divided into a soft plaque group (n = 50) and a nonsoft plaque group (n = 70). All patients underwent angiographic and intravascular ultrasound follow-up at 6 ...
Two cross-sectional studies of adults showed no association between CRP levels and carotid intima-medial thickness (IMT) measured by ultrasound.21,22 Two other studies found no association between serum CRP and coronary artery calcification.23,24 The Framingham Study found an association between CRP and internal carotid IMT (but not common carotid IMT) only in women.25. CRP levels were higher in subjects dying with, but not resulting from, severe coronary atherosclerosis, and were also higher in subjects dying because of recent coronary thrombosis without infarction, than in subjects dying from noncardiovascular causes with minimal coronary atherosclerosis.26 Immune reactivity to heat shock proteins, but not CRP concentration, was associated with carotid and femoral IMT in young (17 to 18 years) men.27 Human transgene expression accelerated aortic atherosclerosis in apolipoprotein E-deficient mice.28. The AHA classification system is based on a temporal sequence that is deduced from lesions ...
BackgroundInflammation and microvascular dysfunction (MVD) are independently associated with adverse cardiovascular outcomes in patients with ischaemic heart disease. This study aimed to assess the relationship between inflammation, MVD and myocardial injury.MethodsCoronary microvascular function was assessed in 74 patients undergoing percutaneous coronary intervention (PCI) using the index of microvascular resistance (IMR) by a pressure-temperature sensor-tipped wire. Serum high-sensitivity C-reactive protein (hsCRP) level was quantified by rate turbidimetry. Severe MVD was defined as IMR|30. Pearson correlation was computed to assess the relationships between hsCRP, troponin and IMR of culprit vessel. Predictors of severe MVD were assessed by regression analysis. ResultsAcute coronary syndromes (ACS) represented 49% of the total cohort. Study cohort was divided into Low CRP (hsCRP3mg/L) groups. There was higher representation of smokers (78% vs. 52%), diabetics (39% vs. 18%) and ACS (61% vs. 33%), as
Our Canary Club High Sensitivity C-Reactive Protein (hs-CRP) blood-spot test provides an accurate assessment of the amount of inflammation in the body to provide physicians with more diagnostic clues regarding a persons cardio metabolic risk.. People who have hs-CRP levels in the high end of the normal range have a 1.5 to 4 times greater risk of having a heart attack as those in the low end of the normal range.. Measurement of hs-CRP does not reflect where in the body the inflammation is, however. It may reflect inflammation detected in cells in the fatty deposits of arterial walls, or it may reflect inflammation from any part of the body. However, when hs-CRP is tested in combination with other cardio metabolic markers, physicians can find valuable clues regarding a persons risk for type 2 diabetes, heart attack, and stroke.. Symptoms of irregular hs-CRP levels:. ...
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
C-reactive protein (CRP) concentration is a heritable systemic marker of inflammation that is associated with cardiovascular disease risk. Genome-wide association studies have identified CRP-associated common variants associated in ∼25 genes. Our aims were to apply exome sequencing to (1) assess whether the candidate loci contain rare coding variants associated with CRP levels and (2) perform an exome-wide search for rare variants in novel genes associated with CRP levels. We exome-sequenced 6050 European-Americans (EAs) and 3109 African-Americans (AAs) from the NHLBI-ESP and the CHARGE consortia, and performed association tests of sequence data with measured CRP levels. In single-variant tests across candidate loci, a novel rare (minor allele frequency = 0.16%) CRP-coding variant (rs77832441-A; p.Thr59Met) was associated with 53% lower mean CRP levels (P = 2.9 × 10(-6)). We replicated the association of rs77832441 in an exome array analysis of 11 414 EAs (P = 3.0 × 10(-15)). Despite a strong effect
The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).. Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.. Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic inflammatory and cardiovascular diseases, smokers or on antiplatelet therapy were excluded. In all the 178 subjects (65.2±10.7 years, 71 men and 107 women) enrolled, we measured hs-CRP, waist circumference (WC), fasting plasma glucose (FPG), systolic and diastolic blood pressure, high density lipoprotein-cholesterol (HDL-Ch), triglycerides (TGs), and 24 h. Albumin excretion (ALB-e). The MS was defined according to the IDF criteria. Student s t-test was used to compare the means, and the Mann Whitney U test to analyze the relationship between hs-CRP levels and the presence of ...
The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin (P for trend = .007), pyridoxine (P for trend = .042), and cobalamin (P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin (P for trend = .084) and pyridoxine (P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile.. CONCLUSION ...
Lupus and elevated c reactive protein levels - Whatcauses high c-reactive protein ihave IBS andfamily history of lupus could either of these be the cause? CRP. Is just a marker for inflammation whatever the cause.
In 2005, from September to November, 527 patients were admitted to the ICU. Of them, 435 (82.5%) patients were admitted for postoperative care, and 219 (50.3%) were male. The mean age of the whole group was 62.02 ± 16 years. Nine (2.06%) patients died during the postoperative period. Among the patients who died, the mean APACHE and SAPS 2 scores were 17.67 ± 9.40 and 52.4 ± 18.31, respectively. Among those who survived, the mean APACHE and SAPS 2 scores were 12.11 ± 6.35 and 24.66 ± 13.03, respectively. Plasma CRP levels during the first 3 days of the ICU stay were not statistically different between patients who survived and those who died. On the fourth day, the plasma CPR level was significantly higher in the group who died, compared with those who survived (28.133 ± 4.77 vs 13.849 ± 10.4; P = 0.037). Of interest is the fact that, on admission, the APACHE and SAPS 2 scores were higher in the group who survived. The area under the ROC curve for the analysis of plasma CRP levels on the ...
C-reactive protein is a sensitive but nonspecific systemic marker of inflammation. Several prospective studies have investigated the association of prediagnostic circulating C-reactive protein concentrations with the development of colorectal cancer, but the results have been inconsistent. We performed a systematic review of prospective studies of the association between prediagnostic measurements of circulating high-sensitivity C-reactive protein and development of invasive colorectal cancer. Authors of original studies were contacted to acquire uniform data. We combined relative risks (RR) for colorectal cancer associated with a one unit change in natural logarithm-transformed high-sensitivity C-reactive protein using inverse variance weighted random effects models. We identified eight eligible studies, which included 1,159 colorectal cancer cases and 37,986 controls. The summary RR per one unit change in natural log-transformed high-sensitivity C-reactive protein was 1.12 (95% confidence intervals
TY - JOUR. T1 - Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. AU - Soedamah-Muthu, S.S.. AU - Livingstone, Shona J.. AU - Charlton-menys, Valentine. AU - Betteridge, D. John. AU - Hitman, Graham A.. AU - Neil, H. Andrew W.. AU - Bao, Weihang. AU - Demicco, David A.. AU - Preston, Gregory M.. AU - Fuller, John H.. AU - Stehouwer, Coen D. A.. AU - Schalkwijk, Casper G.. AU - Durrington, Paul N.. AU - Colhoun, Helen M.. PY - 2015/7/1. Y1 - 2015/7/1. U2 - 10.1007/s00125-015-3586-8. DO - 10.1007/s00125-015-3586-8. M3 - Article. VL - 58. SP - 1494. EP - 1502. JO - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. JF - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. SN - 0012-186X. IS - 7. ER - ...
C-reactive protein has been used to identify patients at high risk for infectious morbidity with preterm labor or preterm rupture of membranes. In this article we report on 104 patients with preterm labor symptoms (n = 45) or preterm rupture of the membranes (n = 59) and serial evaluations of C-reactive protein measured by latex agglutination and laser nephelometry. The simple, inexpensive latex method appears comparable to the laser method in predicting infectious morbidity and can be used clinically. Elevated C-reactive protein values before delivery predict infectious morbidity in only 8% to 29% of patients, and up to 18% of patients with serious infections may be misdiagnosed as having normal C-reactive protein values before delivery.
Kovacs, A, Green, F, Hansson, LO, Lundman, P, Samnegard, A, Boquist, S, Ericsson, CG, Watkins, HH, Hamsten, A and Tornvall, P (2005) A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein ...
Background and Purpose- Recent studies described an association between elevated levels of C-reactive protein (CRP) and outcome after ischemic stroke. We investigated the impact of early serial CRP measurements in hyperacute ischemic stroke on long-term outcome.. Methods- One hundred twenty-seven consecutive patients without thrombolysis with a first ischemic stroke no more than 12 hours after symptom onset were examined. Serial CRP measurements were done at admission (CRP 1), within 24 hours (CRP 2), and within 48 hours (CRP 3) after symptom onset. In addition to several cerebrovascular risk factors, the 1-year outcome and the lesion volumes of initial diffusion-weighted images were determined.. Results- The CRP concentration increased significantly during the first 48 hours after symptom onset (CRP 1, 0.86 mg/dL [95% CI, 0.69 to 1.02]; CRP 2, 1.22 mg/dL [95% CI, 0.88 to 1.55]; CRP 3, 1.75 mg/dL [95% CI, 1.25 to 2.25]; P=0.003). Multiple logistic regression analysis identified Barthel Index ...
Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients - Volume 101 Issue 8 - An Pan, Wendy Demark-Wahnefried, Xingwang Ye, Zhijie Yu, Huaixing Li, Qibin Qi, Jianqin Sun, Yanqiu Chen, Xiafei Chen, Yong Liu, Xu Lin
TY - JOUR. T1 - Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab. T2 - A retrospective analysis of the ACCENT i trial. AU - Cornillie, Freddy. AU - Hanauer, Stephen B.. AU - Diamond, Robert H.. AU - Wang, Jianping. AU - Tang, Kezhen L.. AU - Xu, Zhenhua. AU - Rutgeerts, Paul. AU - Vermeire, Séverine. PY - 2014/11/1. Y1 - 2014/11/1. N2 - Background Serum infliximab trough levels correlate with efficacy; dose escalation is often beneficial in patients with Crohns disease who stop responding to infliximab treatment.Objective To carry out a post hoc analysis of A Crohns Disease Clinical Trial Evaluating Infliximab in a New Long-term Treatment Regimen I (ACCENT I) to evaluate the association between serum infliximab trough levels and C-reactive protein (CRP) after 14 weeks of induction treatment with durable sustained long-term response (Crohns Disease Activity Index decrease ≥70 points and ...
Serum concentrations of CRP increase several hundredfold in response to bacterial infection, making it an attractive diagnostic test for neonatal sepsis. Because many of the more than 70 publications on this subject that have appeared during the past 30 years were flawed by imprecise diagnostic criteria, absent or inappropriate controls (eg, healthy neonates), incomplete description of results, or inadequate sample sizes, the role of this test in evaluation of neonates remains controversial. Early reports described a high prevalence of elevated CRP levels in infected infants, but levels are elevated in only 35% to 65% of neonates with bacterial infection at the onset of illness. Recognition that a delay of at least several hours is intrinsic to the cascade of events leading to elevation of serum CRP levels (including activation of neutrophils, elaboration of interleukin-6, and induction of hepatic synthesis of CRP) led to appropriate criticism of this test as having insufficient sensitivity to ...
The initiation and development of cardiovascular disease is believed to be partly linked to inflammation and much attention has been given...
As an acute-phase protein, human C-reactive protein (CRP) is clinically important. CRPs were purified from several samples in six different pathological conditions, where their levels ranged from 22 to 342 μg/ml. Small, but significant, variations in electrophoretic mobilities on native PAGE suggested differences in molecular mass, charge and/or shape. Following separation by SDS/PAGE, they showed single subunits with some differences in their molecular masses ranging between 27 and 30.5 kDa, but for a particular disease, the mobility was the same for CRPs purified from multiple individuals or pooled sera. Isoelectric focusing (IEF) also indicated that the purified CRPs differed from each other. Glycosylation was demonstrated in these purified CRPs by Digoxigenin kits, neuraminidase treatment and binding with lectins. The presence of N-linked sugar moiety was confirmed by N-glycosidase F digestion. The presence of sialic acid, glucose, galactose and mannose has been demonstrated by gas liquid ...
(2014) Magro et al. Journal of Crohns and Colitis. Background: Infliximab (IFX) is effective in treating Crohns disease (CD) and C-reactive protein (CRP) is a useful biomarker in assessing inflammatory activity. Aim: Correlate CRP levels before beginning of IFX, at week 14 and CRP delta within ...
C-reactive protein (CRP) is an acute-phase reactant frequently used in histochemistry like a marker of ongoing inflammation. [AA] 218 to 232) was identified by CP-724714 monoclonal antibodies CRP-8 and 9C9. This epitope region of Hsp60 displays 26.6% amino acid identity to CRP AA region 77 to 90. These data suggest that the B-cell epitopes shared between CRP and Hsp60 give rise to a true mimicry-based cross-reaction and the induction of cross-reactive antibodies. Our study underlines the importance of thorough study design and careful interpretation of results while using polyclonal anti-CRP antibodies for histochemistry, especially at low dilutions. Furthermore, analytical interference with Hsp60 in CRP assays should also become tested. C-reactive protein (CRP) is an acute-phase reactant in humans, rabbits, and a number of additional mammalian varieties. It is indicated and secreted primarily by hepatocytes, but recently, local production at sites of swelling by monocytes has also been reported ...
High sensitivity C-reactive protein (hsCRP) is an acute phase reactant and a sensitive marker of inflammation. Hyperglycemia can potentially promote the production of CRP. The aim of this study was to determine whether increased fasting plasma glucose (FPG) levels are associated with elevated hsCRP concentrations by gender. We recruited 822 men (mean age, 61 ± 14 years) and 1,097 women (63 ± 12 years) during their annual health examination from a single community. We cross-sectionally examined whether FPG levels are associated with hsCRP concentrations, and whether this association is independent of gender, body mass index (BMI) and other components of the metabolic syndrome. In women only, hsCRP increased significantly and progressively with increasing FPG (r = 0.169, P | 0.001). The stepwise multiple linear regression analysis using hsCRP as an objective variable, adjusted for confounding factors as explanatory variables, showed that FPG as well as age, BMI, systolic blood pressure, high-density
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.
We recruited a random sample of men aged 50-69 years from the registers of general practices in the Merton, Sutton, and Wandsworth District Health Authority area, south London. A total of 612 men were invited and 413 (67%) attended. Of these, 25 were non-white and were excluded. Information was obtained on history and symptoms of coronary heart disease, lifestyle, and socioeconomic circumstances, as described previously. Cardiovascular risk factor profiles and serological tests for H pylori and C pneumoniae were also performed as described.11 Electrocardiograms were Minnesota coded. We took tracings to indicate coronary heart disease if they showed any of the following: Q waves, ST segment depression, left bundle branch block, or T wave inversion. Only the 303 men who had complete cardiovascular risk factor profiles were included in the study.. C Reactive protein concentration was measured by in house enzyme linked immunosorbent assay (ELISA). Rabbit antihuman C reactive protein (Dako) was used ...
Results The prevalence of RCT was higher in patients with HOA group (192/307, 62.5%) than those without HOA (410/827, 49.5%, p,0.010). Among 307 with HOA, patients with RCT were older (62.69±7.04 vs. 59.11 ±7.69, p,0.001) and showed higher hs-CRP (1.51±3.78 vs. 0.67±0.70, p=0.004) and lower HDL levels (55.66±15.46 vs. 60.48±12.45, p=0.003) compared to those without RCT. There were no significant differences in gender, smoking, comorbidities, work period, body mass index, number of affected joints, HOA severity, and prevalence of erosive HOA between both groups. Multiple logistic regression analysis showed significant associations of age (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.02 - 1.10), serum levels of hsCRP (OR 1.37, CI 1.04 - 1.80), and HDL (OR 2.13, CI 1.14 - 3.98) with RCT in HOA patients. ...
C-reactive proteins are proteins that identify viral and bacterial infections that can cause inflammation. They are also used in identifying colon cancer and pulmonary disease. Normal C-reactive proteins have a protein structure that resembles a jellyroll. C-reactive proteins are part of the pentraxin family and were first identified by Tillet and Frances.
Discordance between serum CRP and ESR is not uncommon (1,2). This phenomenon may be due to a variety of factors including the fact that the kinetics of these two tests is quite different, as discussed in another P4P Post. In a study of CRP/ESR discordance (defined as results differing by 2 or 3 quartiles) in…
A study of the association of Herpes simplex virus 1 and 2 exposure to early atherosclerosis using high C-reactive protein level as a marker was carried out in US born, non-pregnant, 20-49 year olds participating in a national survey between 1999 and 2004. Participants were required to have valid results for Herpes simplex virus 1 and 2 and C-Reactive Protein for inclusion. Cases were those found to have a high C-reactive protein level of 0.3-1 mg/dL, while controls had low to normal values (0.01-0.29 mg/dL). Overall, there were 1211 cases and 2870 controls. Mexican American and non-Hispanic black women were much more likely to fall into the high cardiac risk group than the other sex race groups with proportions of 44% and 39%, respectively. ^ Herpesvirus exposure was categorized such that Herpes simplex virus 1 and 2 exposure could be studied simultaneously within the same individual and models. The HSV 1+, HSV 2- category included the highest percentage (45.63%) of participants, followed by HSV 1-,
Provides device manufacturers and FDA staff with updated recommendations concerning 510(k) submissions for various types of assays for C Reactive Protein (CRP).
We evaluated the association of the APOE polymorphism with serum C-reactive protein levels and white blood cell count in two large population-based studies in Korean. The datasets included the Dong-gu study (n = 8,893) and the Namwon Study (n = 10,032). APOE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. Multivariable linear regression analysis was performed to evaluate the relationship of APOE genotypes with C-reactive protein levels and white blood cell count with adjustments for age, sex, body mass index, smoking, diabetes, hypertension, and serum lipids. In the multivariate model, carriers of E3E4 or E4E4 genotype had significantly lower C-reactive protein levels compared with carriers of E3E3 genotype group (0.50 mg/L vs. 0.67 mg/L; 0.37 mg/L vs. 0.67 mg/L, respectively, for the Dong-gu Study and 0.47 mg/L vs. 0.66 mg/L; 0.45 mg/L vs. 0.66 mg/L, respectively, for the Namwon Study). However, there was no difference in white blood cell count ...
TY - JOUR. T1 - Lower C-reactive protein and better hemodialysis survival are associated with regular exercise activity. T2 - Longitudinal outcomes from the ACTIVE-ADIPOSE special study. AU - Kutner, Nancy G.. AU - Zhang, Rebecca. AU - Huang, Yijian. AU - Kaysen, George. AU - Park, Jeanie. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Introduction Cross-sectional and longitudinal studies in the general population have shown that a physically active lifestyle may have anti-inflammatory properties, but evidence from studies conducted with maintenance hemodialysis (HD) patients is limited. Methods A multicenter prospective cohort of 755 HD participants aged 20-92 was evaluated in a USRDS special study 2009-2013. Kilocalories/week (kcal/week) of leisure time physical activity (LTPA) was estimated from the Minnesota Leisure Time Activity questionnaire. Predialysis serum samples were obtained concurrent with LTPA report date. Generalized estimating equations (GEE) examined association of participants LTPA and ...
Description of disease C-Reactive Protein Test (CRP). Treatment C-Reactive Protein Test (CRP). Symptoms and causes C-Reactive Protein Test (CRP) Prophylaxis C-Reactive Protein Test (CRP)
Use of statin and/or aspirin therapy had negligible effects on the comparisons with the HNF1A-MODY group (Table 1). In the type 2 diabetic group, the hs-CRP level was the same for the statin/aspirin users as for the nonusers (P = 0.27), whereas in the type 1 diabetic group those taking statins and/or aspirin had a higher hs-CRP than nonusers (P = 0.004). Thus, it seems unlikely that use of these drugs would lower hs-CRP toward the range seen in the HNF1A-MODY group. In contrast, adjustment for BMI had a large impact on the estimated means (Table 1) and, given the correlation between BMI and CRP (r2 = 0.28, P , 10−6 for control subjects), abolished much of the difference observed between the type 2 diabetic and other groups. However, the differ- ences in hs-CRP levels between the HNF1A-MODY and other groups were preserved (P ≤ 0.01). Estimated mean adjusted hs-CRP (95% CI) levels for the HNF1A-MODY group compared with the other diabetic groups combined were 0.28 (0.16-0.49) vs. 0.82 ...
Use of statin and/or aspirin therapy had negligible effects on the comparisons with the HNF1A-MODY group (Table 1). In the type 2 diabetic group, the hs-CRP level was the same for the statin/aspirin users as for the nonusers (P = 0.27), whereas in the type 1 diabetic group those taking statins and/or aspirin had a higher hs-CRP than nonusers (P = 0.004). Thus, it seems unlikely that use of these drugs would lower hs-CRP toward the range seen in the HNF1A-MODY group. In contrast, adjustment for BMI had a large impact on the estimated means (Table 1) and, given the correlation between BMI and CRP (r2 = 0.28, P , 10−6 for control subjects), abolished much of the difference observed between the type 2 diabetic and other groups. However, the differ- ences in hs-CRP levels between the HNF1A-MODY and other groups were preserved (P ≤ 0.01). Estimated mean adjusted hs-CRP (95% CI) levels for the HNF1A-MODY group compared with the other diabetic groups combined were 0.28 (0.16-0.49) vs. 0.82 ...
Apolipoprotein E (APOE) plays a major role in lipid metabolism and inflammation. However, the association between APOE gene polymorphisms and serum triglyceride levels remains controversial. We tested the effects of APOE variants on triglyceride levels and their interactions with the inflammatory marker C-reactive protein (CRP) in a Taiwanese population. Two APOE single nucleotide polymorphisms (SNPs) rs429358 and rs7412 were genotyped by TaqMan Assay using real time PCR in 595 healthy subjects attending the clinic for routine visits. After adjustment for clinical covariates, subjects carrying the rs429358-TT genotype and non-ε4 alleles were found to have higher CRP levels, whereas those with rs7412-CC genotype and non-ε2 alleles had significantly higher total and low-density lipoprotein cholesterol levels (all P | 0.01). Using subgroup and interaction analyses, we observed significantly lower triglyceride levels in subjects carrying the rs429358-TT genotype and non-ε4 alleles in the low CRP group (P
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PubMed journal article Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrom were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Prognostic role of serum C-reactive protein in esophageal cancer: a systematic review and meta-analysis Ying Huang,1 Ji-Feng Feng,2 Jin-Shi Liu,2 Qi-Xun Chen21Department of Operating Theatre, 2Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaBackground: Recent studies have shown that C-reactive protein (CRP) is a useful predictive factor in several cancers; however, its role in esophageal cancer (EC) is controversial.Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I2
Background: C-reactive protein (CRP) is often used as a clinical marker of acute systemic inflammation. Since low grade inflammation is evident in chronic diseases such as chronic obstructive pulmonary disease (COPD), new methods have been developed to enhance the sensitivity of CRP assays in the lower range. A study was undertaken to investigate the discriminative value of high sensitivity CRP in COPD with respect to markers of local and systemic impairment, disability, and handicap. Methods: Plasma CRP levels, interleukin 6 (IL-6) levels, body composition, resting energy expenditure (REE), exercise capacity, health status, and lung function were determined in 102 patients with clinically stable COPD (GOLD stage II-IV). The cut off point for normal versus raised CRP levels was 4.21 mg/l. Results: CRP levels were raised in 48 of 102 patients. In these patients, IL-6 ( ...
C-Reactive Protein antibody LS-C14638 is an unconjugated mouse monoclonal antibody to human C-Reactive Protein (CRP). Validated for ELISA and WB.
C reactive protein[edit]. C reactive protein, a protein made in the liver generally increases with inflammation, and may be ... The human immune system typically produces both T cells and B cells that are capable of being reactive with self-protein, but ... Autoimmunity, on the other hand, is the presence of self-reactive immune response (e.g., auto-antibodies, self-reactive T cells ... A test used to identify abnormal proteins, known as antinuclear antibodies, produced when the body attacks its own tissues.[37] ...
C-Reactive Protein. Level of inflammation with the body. If the immune system is fighting an infection or illness, CRP will be ... This test reveals the levels of waste products, enzymes and proteins that are processed by the liver.. ... Biomarker (medicine), a protein or other biomolecule measured in a blood test ...
Declining protein levels were the most evident for the E1k and E2k subunits, when compared to the control. On contrary, as the ... 2004) Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase, J. Neurosci. 24, ... The E2k (dihydrolipoamide acyltransferase, lipoic acid and CoASH cofactors, EC subunit is a core protein and is the ... Figure 14: The changes in the protein levels for each α-KGDHC subunit in the sub-medial thalamic nucleus (vulnerable to ...
"C-reactive protein". GPnotebook. 2730 Serum C-Reactive Protein values in Diabetics with Periodontal Disease Archived 2008-12-20 ... Acute phase proteins are markers of inflammation. Autoantibodies are usually absent or very low, so instead of being given in ... Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. Note: ... Electrolytes and metabolites: For iron and copper, some related proteins are also included. Cardiology diagnostic tests and ...
... elevated C-reactive protein; failure to sterilize the CSF before immune recovery. IRIS may be the cause of paradoxically worse ... protein, glucose) increase. CSF culture is typically sterile, and there is no increase in CSF cryptococcal antigen titer. The ...
Drahl, C.; Cravatt, B. F.; Sorensen, E. J. (2005). "Protein-reactive natural products". Angew. Chem. Int. Ed. Engl. 44 (36): ... There, the cargo will be released when the Ran-GTP protein is hydrolyzed by a cytoplasmic Ran-GTPase enzyme to form Ran-GDP. ... These molecules include regulatory proteins such as Rev, MAPK/MEK1, c-Abl, Cyclin B1, MDM2/p53, IkB, MPF, and PKA. The most ... The acyl groups are loaded onto the acyl carrier protein (ACP) with the help of the acyltransferase (AT) domain. Each module ...
... such as a high-sensitivity C-reactive protein test (CRP) measuring CRP, a protein in found in blood that indicates inflammation ... "C-reactive protein test". Mayo Clinic. Retrieved 2019-01-18. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, ...
This, in turn, requires them to be protein-reactive. The conjugate formed is then recognized as a foreign body by the ... involving their association with epidermal proteins forming hapten-protein conjugates. ... Langerhans cells (LCs) (and in some cases other Dendritic cells (DCs)), which then internalize the protein; transport it via ...
C-reactive protein, another inflammatory marker, may be elevated.[20]. *LFTs, liver function tests, are abnormal particularly ...
... damage or loss of vitamins and proteins; production of potential cancerogenic reactive radicals. In Australia, following cat ...
C-reactive protein will be elevated. Liver function tests may show evidence of hepatic inflammation and low serum albumin ... Urinalysis may show white blood cells and protein in the urine (pyuria and proteinuria) without evidence of bacterial growth. ...
... binning Mimotope Odotope Polyclonal B cell response Protein tag TimeSTAMP protein labelling Cryptotope Huang J, Honda W ... Epitopes are sometimes cross-reactive. This property is exploited by the immune system in regulation by anti-idiotypic ... The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their ... Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of ...
C-reactive protein (CRP) is an acute phase protein. Therefore, it is a better marker for acute phase reaction than ESR. While ... Arik N, Bedir A, Günaydin M, Adam B, Halefi I (October 2000). "Do erythrocyte sedimentation rate and C-reactive protein levels ... Falk, G.; Fahey, T. (2008). "C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of ... MedlinePlus Encyclopedia: ESR Harrison, Michael (June 2015). "Erythrocyte sedimentation rate and C-reactive protein". ...
Mitochondrial SNO-proteins inhibit Complex I of the electron transport chain; modulate mitochondrial reactive oxygen species ( ... Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (February 2005). "Protein S-nitrosylation: purview and parameters". Nat. ... Derakhshan B, Hao G, Gross SS (July 2007). "Balancing reactivity against selectivity: the evolution of protein S-nitrosylation ... It was particularly noteworthy that in cultured normal rat cholangiocytes, GSNO activated protein kinase B, protected against ...
... is also used in protein crystallography. Applied at pressures from 0.5 to 5 MPa (5 to 50 atm) to a protein crystal, xenon ... ISBN 978-0-7803-8265-7. Staff (2007). "Neil Bartlett and the Reactive Noble Gases". American Chemical Society. Retrieved June 5 ... For instance, xenon dissolved in water, xenon dissolved in hydrophobic solvent, and xenon associated with certain proteins can ... Staff (December 21, 2004). "Protein Crystallography: Xenon and Krypton Derivatives for Phasing". Daresbury Laboratory, PX. ...
... triggers reactive oxygen species (ROS). ROS production disrupts protein folding and induces the unfolded protein ...
Protein Crystallography: Xenon and Krypton Derivatives for Phasing. Daresbury Laboratory, PX. 2004-12-21 [2007-10-01]. (原始内容存档于 ... Neil Bartlett and the Reactive Noble Gases. American Chemical Society. 2007 [2013-12-13].. ... Principles of Protein X-Ray Crystallography 3rd. New York: Springer. 2007: 123-171. ISBN 978-0-387-33334-2. doi:10.1007/0-387- ...
... s are commercially available as reactive succinimidyl-esters for labeling proteins through lysine residues, and as ... CS1 maint: discouraged parameter (link) "DyLight Reactive Dyes". Pierce Protein Research Products. Retrieved 2014-09-10. CS1 ... CS1 maint: discouraged parameter (link) "DyLight Reactive Dyes". Pierce Protein Research Products. 2008. Retrieved 2013-10-17. ... Pierce Protein Research Products. 2011. Archived from the original on 2013-10-17. Retrieved 2013-10-17. ...
C-reactive protein is elevated in most cases. Prostate biopsies are not indicated as the (clinical) features (described above) ...
This test utilises the acute phase proteins (C-Reactive Protein and Haptoglobin). In combination with basic clinical symptoms, ... Serum thymadine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease. K A ... Hypercalcemia in these cases is caused by secretion of parathyroid hormone-related protein. Multicentric lymphoma presents as ...
Paraskevas S, Huizinga JD, Loos BG (April 2008). "A systematic review and meta-analyses on C-reactive protein in relation to ... Periodontitis has been linked to increased inflammation in the body, such as indicated by raised levels of C-reactive protein ... D'Aiuto F, Ready D, Tonetti MS (August 2004). "Periodontal disease and C-reactive protein-associated cardiovascular risk". ... There are six sub-types: Genetic/developmental disorders, specific infections, inflammatory and immune conditions, reactive ...
Uncoupling proteins also reduce generation of reactive oxygen species. Mitochondrial uncoupling protein 3 (UCP3) is a members ... Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. The gene is located in chromosome ( ... Uncoupling protein UPC2 and uncoupling protein UPC3 interaction with members of the 14.3.3 family (Benoit pierrat et al., 2000 ... UCP3 (uncoupling protein) deliberates the hypoxia resistance to the renal epithelial cells and its upregulation in renal cell ...
Davies MJ (January 2004). "Reactive species formed on proteins exposed to singlet oxygen". Photochem. Photobiol. Sci. 3 (1): 17 ... In the cornea ALDH3A1: (1) prevents the formation of 4-HNE protein adducts that would impeded proteins' function; (2) is more ... In the presence of molecular oxygen, UVR leads to the formation of reactive oxygen species (ROS) that are implicated in many ... ALDH3A1 expression is notably high in the cornea of mammalian species, comprising from 5 to 50% of soluble protein content, but ...
"Ovine IgA-reactive proteins from Teladorsagia circumcincta infective larvae". International Journal for Parasitology. 44 (10): ... Lesions in the epithelial barrier allow a loss of protein and in addition protein is diverted to tissue repair and immune and ... Supplementation with protein or non-protein nitrogen sources appear more important than supplementation with energy sources. ... Non-protein sources such as urea are effective and relatively cheap but great care would be needed to avoid toxicity with high ...
C-reactive protein (CRP) may help support the diagnosis. For those with CRP less than 20 mg/L without convincing evidence of ... C-reactive protein level, and possibly liver function tests - are recommended. The diagnosis of influenza-like illness can be ... In the lower airways, reflexes of the glottis, actions of complement proteins and immunoglobulins are important for protection ... "Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine". The New England ...
Serum levels of C-reactive protein (CRP), a putative marker of inflammation and predictor of CHD (coronary heart disease) risk ... Stewart, SH; Mainous, AG; Gilbert, G (2002). "Relation between alcohol consumption and C-reactive protein levels in the adult ... Albert, MA; Glynn, RJ; Ridker, PM (2003). "Alcohol consumption and plasma concentration of C-reactive protein". Circulation. ... Chronic consumption alcohol can also increase breakdown of important proteins in our body which can affect gene expression. ...
... in contrast to other acute phase proteins, e.g., C-reactive protein, which increase in case of acute inflammation). ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ... The protein is composed of alpha helices and beta sheets that form two domains. The N- and C- terminal sequences are ... When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, e.g., erythroid ...
Jiang N, Tan NS, Ho B, Ding JL (October 2007). "Respiratory protein-generated reactive oxygen species as an antimicrobial ... Protein 4.1R-based macromolecular complex - proteins interacting with Protein 4.1R. Protein 4.1R - weak expression of Gerbich ... PIP2 enhances the binding of protein band 4.1R to glycophorin C but decreases its interaction with protein band 3, and thereby ... Structural role - The following membrane proteins establish linkages with skeletal proteins and may play an important role in ...
A 2018 systematic review comparing PCT and C-reactive protein (CRP) found PCT to have a sensitivity of 80% and a specificity of ... Tan M, Lu Y, Jiang H, Zhang L (November 2018). "The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A ... PCT also outperformed other biomarkers such as C-reactive protein. Evidence shows that an elevated PCT above .5 ng/mL could ... PCT had a sensitivity of 54% and specificity of 95%. The study also concluded that PCT outperforms C-reactive protein in ...
Among these protein targets, the enzyme N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) generates bioactive ... Exposure of colonic cells to high DCA concentrations increase formation of reactive oxygen species, causing oxidative stress, ... Bile acids bind to some other proteins in addition to their hormone receptors (FXR and TGR5) and their transporters. ... the farnesoid X receptor and G protein-coupled bile acid receptor/TGR5.[7][10] They bind less specifically to some other ...
Carnivorous mammals have a simple digestive tract because the proteins, lipids and minerals found in meat require little in the ... Many laboratory studies showed that overweight individuals are more emotionally reactive and are more likely to overeat when ... Other peptides in the hypothalamus that induce eating are neuropeptide Y (NPY) and agouti-related protein (AGRP).[20] ... 1/4 protein food as meat, ... and 1/4 carbohydrates as pasta, rice, ...) will then account to some 1800-2000 kcal, which is the ...
... protein.[45] PPARα increases the activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of ... this generates free radicals and reactive oxygen species in the skin, which purposefully damage the sebaceous glands and kill C ... These free radicals likely interfere with the bacterium's metabolism and ability to make proteins.[79][80] Additionally, ... Squalene oxidation activates NF-κB (a protein complex) and consequently increases IL-1α levels.[45] Additionally, squalene ...
Thus, contrary to expectation, caesium is the most reactive of the alkali metals, not francium.[68][37]:1729[87] All known ... The balance between potassium and sodium is maintained by ion transporter proteins in the cell membrane.[231] The cell membrane ... All the alkali metals are highly reactive and are never found in elemental forms in nature.[20] Because of this, they are ... The alkali metals are all shiny, soft, highly reactive metals at standard temperature and pressure and readily lose their ...
2003). "Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine". N. Engl. ... lebel ng C-reactive na protina at malamang na mga pagsusuri sa paggana ng atay-ay inirerekomenda.[37] Ang pagkilala sa ...
... detoxication of the lipid peroxide-derived reactive aldehydes". Plant Cell Physiol. 43 (12): 1445-55. doi:10.1093/pcp/pcf187. ... proteins. In enzymology, a 2-alkenal reductase (EC is an enzyme that catalyzes the chemical reaction ...
Visual representation of protein denaturation. A globular protein becomes unfolded when exposed to heat. ... The copper in the bowl assists in creating a tighter bond in reactive sulfur items such as egg whites. The bond created is so ... Some protein powders also use egg whites as a primary source of protein. ... Egg white is an alkaline solution and contains around 148 proteins.[4] The table below lists the major proteins in egg whites ...
"Bioethers are produced by the reaction of reactive iso-olefins, such as iso-butylene, with bioethanol."[55] Bioethers are ...
Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ... Kelly CJ, Stenton SR, Lashen H. Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis. ...
FITC reacts with the amine groups of many biologically relevant compounds including intracellular proteins to form a thiourea ... succinimidyl ester modified fluorescein, i.e. NHS-fluorescein, is another common amine-reactive derivative, yielding amide ... allowing biologists to target the fluorophore to specific proteins or structures within cells. This application is common in ...
Proteins do not have to unfold to be imported into the peroxisome. The protein receptors, the peroxins PEX5 and PEX7, accompany ... Corpas FJ, Barroso JB, del Río LA (Apr 2001). "Peroxisomes as a source of reactive oxygen species and nitric oxide signal ... The protein content of peroxisomes varies across species or organism, but the presence of proteins common to many species has ... of peroxisomal matrix proteins signals them to be imported into the organelle. There are at least 32 known peroxisomal proteins ...
Consequently, compounds containing Si-H bonds are much more reactive than is H2. The strength of the Si-H bond is modestly ... Hemolithin (possibly 1st extraterrestrial protein found). *H2NCO+. *Linear C5 ...
These proteins, generated by plasma cells, normally bind to pathogens, targeting them for destruction. Absent B cells with a ... like the presence in the environment of a reactive allergen. Other problems become apparent due to aging of bodily and cellular ... Complement deficiencies are the result of a lack of any of these proteins. They may predispose to infections but also to ... deficiency Membrane cofactor protein (CD46) deficiency Membrane attack complex inhibitor (CD59) deficiency Paroxysmal nocturnal ...
... identified a protein that later became known as superoxide dismutase as an indophenol oxidase by protein analysis of starch ... Superoxide is one of the main reactive oxygen species in the cell. As a consequence, SOD serves a key antioxidant role. The ... SOD1 is an extremely stable protein. In the holo form (both copper and zinc bound) the melting point is , 90 °C. In the apo ... However, in the chronic stage, SOD does not seem to be sufficient and tends to decrease due to the destruction of proteins from ...
The molecules/atoms of substance in an excited energy state are often much more reactive; that is, more amenable to chemical ... Neurochemistry is the study of neurochemicals; including transmitters, peptides, proteins, lipids, sugars, and nucleic acids; ... Most radicals are comparatively reactive, but some, such as nitric oxide (NO) can be stable. ...
Fractionation of proteins by heparin chromatography։ Methods Mol Biol։ Methods in Molecular Biology™ 424։ 2008։ էջեր 213-21։ ... Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. ... Cell surface heparin sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G ... Coombe D.R., Kett W.C. (2005)։ «Heparan sulfate-protein interactions: therapeutic potential through structure-function insights ...
Rattazzi M, Puato M, Faggin E, et al. (2004). C-reactive protein and interleukin-6 in vascular disease: culprits or passive ...
The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ... This mechanism may depend on an associated water molecule for deprotonation of the reactive threonine hydroxyl. Degradation ... Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks ... Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ...
This leads to antiviral protein production, such as protein kinase R, which inhibits viral protein synthesis, or the 2′,5′- ... causing the release of reactive oxygen species. Pathogens also stimulate the macrophage to produce chemokines, which summon ... "Resistance" (R) proteins, encoded by R genes, are widely present in plants and detect pathogens. These proteins contain domains ... The cascade is composed of many plasma proteins, synthesized in the liver, primarily by hepatocytes. The proteins work together ...
"Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A ... The second factor is the presence of proteins in the liver and bile that either promote or inhibit cholesterol crystallization ...
Savini I, Rossi A, Pierro C, Avigliano L, Catani MV (April 2008). "SVCT1 and SVCT2: key proteins for vitamin C uptake". Amino ... as well as a powerful reducing agent capable of rapidly scavenging a number of reactive oxygen species (ROS). Given that ... The HIFalpha prolyl hydroxylases, termed PHDs/EGLNs (prolyl hydroxylase domain proteins/EGL nine homologues), bind to a ... which lose SVCT proteins during maturation.[105] In both vitamin C synthesizers (example: rat) and non-synthesizers (example: ...
... acid sensing and additional signals such as growth factors and reactive oxygen species regulate the activity of the protein ... WIPI2, a PtdIns(3)P binding protein of the WIPI (WD-repeat protein interacting with phosphoinositides) protein family, was ... Without efficient autophagy, neurons gather ubiquitinated protein aggregates and degrade. Ubiquitinated proteins are proteins ... This allows unneeded proteins to be degraded and the amino acids recycled for the synthesis of proteins that are essential for ...
In order to keep the cytotoxic cells from killing cells just for presenting self-proteins, the cytotoxic cells (self-reactive T ... Immunoglobulin-binding protein - Proteins such as protein A, protein G, and protein L that are capable of binding to antibodies ... An autoantigen is usually a normal protein or protein complex (and sometimes DNA or RNA) that is recognized by the immune ... Lipids and nucleic acids are antigenic only when combined with proteins and polysaccharides.[citation needed] Non-microbial non ...
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... through the PI3K pathway or through reactive oxygen species (ROS)-mediated activation of the STAT3 pathway.[11] Downstream ... a b Proto-Oncogene+Proteins+c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) ... Hannink M, Donoghue DJ (1989). "Structure and function of platelet-derived growth factor (PDGF) and related proteins". Biochim ...
regulation of reactive oxygen species metabolic process. • positive regulation of protein transport. • negative regulation of ... On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other ... protein binding. • protease binding. • tumor necrosis factor receptor binding. • cytokine activity. • identical protein binding ... positive regulation of protein complex assembly. • protein kinase B signaling. • positive regulation of cytokine production. • ...
Protein synthesis RNAs[change , change source]. Messenger RNA[change , change source]. The structure of a mature eukaryotic ... These differences result in RNA being chemically more reactive than DNA. This makes it the more suitable molecule to take part ... Genes code for proteins in bits called exons. The bits can be joined together in different ways to make different mRNAs. Thus, ... from one gene many proteins can be made. This is the process of alternative splicing. Any unwanted versions of the protein get ...
Commonly consumed food components containing calories are carbohydrates, proteins and fat. In preliminary research, some non- ... mitochondrial reactive oxygen species production, and membrane fatty acid composition". J Gerontol A Biol Sci Med Sci. 61 (8): ... brain and heart proteins, and mice placed on CR at 19 months of age show an increases in life span.[44] ... "Dietary Protein and Weight Reduction: A Statement for Healthcare Professionals From the Nutrition Committee of the Council on ...
Next, the NK cells which have Fc Receptors will bind to that antibody, inducing the NK cell to release proteins such as ... During replication of a virus some of the viral proteins are expressed on the cell surface membrane of the infected cell. ... Antibodies can then bind to these viral proteins. ... Reactive arthritis. GVHD. *Transfusion-associated graft versus ...
UMich Orientation of Proteins in Membranes protein/pdbid-2hac - Zeta-zeta dimer of T cell receptor ... Sewell, AK (2012), "Why must T cells be cross-reactive", Nat Rev Immunol, 12 (9): 669-677, doi:10.1038/nri3279, PMID 22918468. ... The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR ... The TCR is a member of the immunoglobulin superfamily, a large group of proteins involved in binding, recognition, and adhesion ...
In addition to their function in protein folding and cellular attachment, the N-linked glycans of a protein can modulate a ... C-mannosylation is unusual because the sugar is linked to a carbon rather than a reactive atom such as nitrogen or oxygen. ... Glycans serve a variety of structural and functional roles in membrane and secreted proteins.[1] The majority of proteins ... disorders of protein N-glycosylation, disorders of protein O-glycosylation, disorders of lipid glycosylation and disorders of ...
High-sensitivity C-reactive protein; hs-CRP; Pentaxin; Pentraxin 1; PTX1 Tillett and Francis (1930) noticed that C ... C-Reactive protein in human atherogenesis: facts and fiction, C-reactive protein in human atherogenesis: facts and fiction. ... Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein ... The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in ...
The use of reactive dyes in biotechnology has burgeoned over the last two decades with the development of new ways of ... exploiting conventional textile dyes for the purification and analysis of proteins ... The use of reactive dyes in biotechnology has burgeoned over the last two decades with the development of new ways of ... This book examines the chemistry of reactive dyes and their extensive application in dye-ligand affinity chromatography, both ...
Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein ... C-reactive protein: a critical update. Mark B. Pepys and Gideon M. Hirschfield Centre for Amyloidosis and Acute Phase Proteins ... Phylogenetic aspects of C-reactive protein and related proteins. Ann. N. Y. Acad. Sci. 1982. 389:49-75. View this article via: ... The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N. Engl. J. Med. 1994. 331: ...
... , C Reactive Protein, CRP, C-RP, High-Sensitivity CRP, hs-CRP. ... C-reactive protein, C-Reactive Protein, Protein, C-Reactive, C Reactive Protein, Proteins, specific or class, C-reactive, C- ... c reactive protein, c-reactive protein (CRP), CRP, c reactive proteins, Pentraxin 1, Short, Pentraxin 1, C reactive protein, ... C-Reactive Protein Aka: C-Reactive Protein, C Reactive Protein, CRP, C-RP, High-Sensitivity CRP, hs-CRP ...
The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that looks at the lower levels of C-reactive protein (CRP ... The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that finds lower levels of C-reactive protein (CRP). This ... The standard test measures high levels of the protein to find different diseases that cause inflammation. The hs-CRP test ... protein measures general levels of inflammation in your body. The hs-CRP can be used to find the risk for heart disease and ...
Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Journal article ... BACKGROUND AND PURPOSE: C-reactive protein (CRP) has evolved as an inflammatory risk marker of cardiovascular disease. Several ... Adult, Aged, Brain Ischemia/*blood/complications/*genetics, C-Reactive Protein/*genetics/*metabolism, Case-Control Studies, ...
Helal I, Zerelli L, Krid M, Kheder A (2012). "Comparison of C-reactive protein and high-sensitivity C-reactive protein levels ... acute phase erythrocyte sedimentation rate C-reactive protein C-reactive protein GRCh38: Ensembl release 89: ENSG00000132693 - ... C-reactive protein Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein (American Heart Association) C- ... "Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares ...
Normal C-reactive proteins have a protein structure that resembles a jellyroll. C-reactive proteins are part of the pentraxin ... C-reactive proteins are proteins that identify viral and bacterial infections that can cause inflammation. They are also used ... Genetic Base of C-Reactive Proteins. First identified by William Tillett and Thomas Frances in 1930, C-reactive proteins were ... Use of C-Reactive Proteins in Diagnosis. Outside of liver failure, C-reactive proteins are consistently produced within the ...
Diseases : C-Reactive Protein (CRP), Inflammation : CK(9572) : AC(3089), Insomnia : CK(902) : AC(114), Low Back Pain : CK(502 ... Diseases : C-Reactive Protein (CRP), Inflammation : CK(9572) : AC(3089). Pharmacological Actions : Anti-Inflammatory Agents : ... Diseases : C-Reactive Protein (CRP), Inflammation : CK(9572) : AC(3089). Pharmacological Actions : Anti-Inflammatory Agents : ... Diseases : C-Reactive Protein (CRP), Diabetes: Glycation/A1C : CK(210) : AC(33), Diabetes Mellitus: Type 2 : CK(8552) : AC(1714 ...
Purchase Protein Sensors of Reactive Oxygen Species, Part A: Selenoproteins and Thioredoxin, Volume 347 - 1st Edition. Print ... Protein Sensors of Reactive Oxygen Species, Part A: Selenoproteins and Thioredoxin, Volume 347 1st Edition. 0 star rating Write ... 7]: Semisynthesis of Proteins Containing Selenocysteine*Introduction. *Strategies for Synthesis of Proteins Containing ... 29]: Protein Electrophoretic Mobility Shift Assay to Monitor Redox State of Thioredoxin in Cells*Introduction ...
Learn how the c-reactive protein test is used to identify the presence of inflammation, to determine its severity, and to ... C-reactive protein (CRP) is an acute phase reactant, a protein made by the liver that is released into the blood within a few ... Tests: High-sensitivity C-reactive protein (hs-CRP); erythrocyte sedimentation rate (ESR). Conditions: Arthritis, Autoimmune ...
MedlinePlus Encyclopedia C-reactive protein. *Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein (American ... C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response ... "Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares ... or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.[4] ...
... Asked. 23 Jun 2015 by myself1956. Updated. 5 ... but an occasional prednisone burst for 10 days then had lab work done wondering if it could have affected c reactive protein ... Is anyone prescribed Humira for Reactive arthritis? (NOT TO BE CONFUSED WITH RHEUMATOID)?. Posted 19 Oct 2017 • 1 answer ...
Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein ... High sensitivity C-reactive protein in asthma. M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, M. ... High sensitivity C-reactive protein in asthma. M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, M. ... High sensitivity C-reactive protein in asthma. M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, M. ...
Multiple antioxidant proteins protect Chlorobaculum tepidum against oxygen and reactive oxygen species.. Li H1, Jubelirer S, ... The encoded proteins include cytochrome bd quinol oxidase, NADH oxidase, rubredoxin oxygen oxidoreductase, several thiol ... To test the physiological functions of some of these proteins, ten genes were insertionally inactivated. Wild-type Cba. tepidum ... results demonstrated that these putative antioxidant proteins combine to form an effective defense against oxygen and reactive ...
"c-reactive proteins". Entries tagged with: c-reactive proteins. 2 result(s) displayed (1 - 2 of 2): ... Read More: apples, asthma, bile, blood sugar, c-reactive proteins, cholesterol, constipation, dates, digestion, dried fruit, ... Read More: apples, asthma, bile, blood sugar, c-reactive proteins, cholesterol, constipation, dates, digestion, dried fruit, ...
CRP is produced as a homo-pentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ... CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ... In terms of pro-inflammatory cytokine production, mCRP increases interleukin-8 and monocyte chemoattractant protein-1 ... is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. ...
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C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.. Ridker PM1, ... The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of ... The markers included high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, and soluble intercellular ...
C reactive protein testing in general practice safely reduces antibiotic use for flare-ups of COPD BMJ 2019; 367 :l5991 ... C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations. N Engl J Med 2019;381:111-20. ... C reactive protein testing in general practice safely reduces antibiotic use for flare-ups of COPD ... C reactive protein testing in general practice safely reduces antibiotic use for flare-ups of COPD ...
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcets Disease. Jun Shimizu,1 Tomoko Izumi, ... We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current ... Heat shock proteins (HSPs) function as an intracellular chaperonin for other proteins, and significant sequence homology is ... T. E. Bramanti, N. P. Dekker, F. Lozada-Nur, J. J. Sauk, and J. A. Regezi, "Heat shock (stress) proteins and γδ T lymphocytes ...
Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial ... The present study investigated the mechanism of LF-induced apoptosis and examined the role of reactive oxygen species (ROS) in ... Overexpression of FLICE-inhibitory protein (FLIP) or B-cell lymphoma-2, which are known inhibitors of the extrinsic and ...
... Atherosclerosis. 2007 Oct;194(2 ... Objective: To examine the association between serum c-reactive protein (CRP) concentration and the metabolic syndrome (MS) ... glucose and c-reactive protein. Data describing socioeconomic and lifestyle factors was also collected. ...
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q86YC3. Q8BMT4. Q8BMT4-3. D3Z2Y0. D3Z755. ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q86YC3. A0A0D9R8E7. UPI00045DECD3. A0A096NBH8. ...
Serum CRP protein was measured in all groups, interpretation of results was applied. Results: The study revealed that serum CRP ... To study the role of C-reactive protein (CRP) in the progression of diabetic retinopathy before and after treatment to ... In 1930, C-reactive protein (CRP) was identified, it is a protein synthesized mainly by liver and adipose tissue, it is ... C-reactive protein was considered a biomarker for PDR, but not a good indictor used for follow up patients after laser ...
C-reactive protein (CRP) is an acute phase reactant with a half-life as short as 19 hours. Therefore, it is conveniently used ... M. B. Pepys and G. M. Hirschfield, "C-reactive protein: a critical update," The Journal of Clinical Investigation, vol. 111, no ... D. Gershov, S. Kim, N. Brot, and K. B. Elkon, "C-reactive protein binds to apoptotic cells, protects the cells from assembly of ... We aimed to determine the role of C-reactive protein in the prediction of clinically relevant fistula development. Materials ...
... consists of a phosphoryl choline covalently linked to beaded agarose and is designed for the purification of C-reactive protein ... CRP, C-reactive protein, is a pentameric protein found in the blood, the levels of which rise in response to inflammation, ... C-Reactive Protein Purification. Immobilized p-Aminophenyl Phosphoryl Choline consists of a phosphoryl choline covalently ... linked to beaded agarose and is designed for the purification of C-reactive protein from plasma, ascites and other biological ...
The upf1Δ strain showed up-regulation of proteins such as the Sec63 protein important for protein assembly in the nucleus and ... Peptide ratios were also grouped into proteins and averaged to arrive at protein-level ratios for those 685 proteins having two ... or down-regulation of protein expression levels was performed only on this latter group of 685 proteins (i.e. protein ... Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents. Philip L. Ross, ...
Reactive Metabolite-induced Protein Glutathionylation: a Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity. ... Reactive Metabolite-induced Protein Glutathionylation: a Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity ... Reactive Metabolite-induced Protein Glutathionylation: a Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity ... Reactive Metabolite-induced Protein Glutathionylation: a Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity ...
The C-reactive protein (CRP), an acute phase reactant which binds selectively to T (thymus-derived) lymphocytes, was found to ... Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts ... Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts ... Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts ...
  • Multiple antioxidant proteins protect Chlorobaculum tepidum against oxygen and reactive oxygen species. (nih.gov)
  • tepidum, a strictly anaerobic photolithoautotroph, is predicted to encode more than ten genes whose products are potentially involved in protection from reactive oxygen species and an oxidative stress response. (nih.gov)
  • The results demonstrated that these putative antioxidant proteins combine to form an effective defense against oxygen and reactive oxygen species. (nih.gov)
  • Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells. (cdc.gov)
  • The present study investigated the mechanism of LF-induced apoptosis and examined the role of reactive oxygen species (ROS) in this process. (cdc.gov)
  • Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. (uniprot.org)
  • Reactive oxygen species (ROS), such as the superoxide anion, the hydroxyl radical and singlet oxygen, can influence cellular processes in many ways. (bioportfolio.com)
  • Studies show that reactive oxygen and nitrogen species (RONS) play key roles in cancer initiation and progression. (aacrjournals.org)
  • Mycobacterium tuberculosis employs defense mechanisms to protect itself from reactive oxygen species (ROS)-mediated cytotoxicity inside macrophages. (jimmunol.org)
  • Reactive oxygen species (ROS) are increasingly recognized as important signaling regulators. (sciencemag.org)
  • Tks proteins organize NADPH oxidase activity and localized production of reactive oxygen species in invasive cells. (sciencemag.org)
  • This study aimed to determine in Hep G2 cells 1) the sensitivity of IGFBP-1 synthesis to treatment with interleukin (IL)-1, tumor necrosis factor-alpha (TNF-alpha), and IL-6, 2) the ability of reactive oxygen species (ROS) to enhance IGFBP-1 production, and 3) the role of ROS in mediating cytokine-induced increases in IGFBP-1. (nih.gov)
  • Plants perceive microbe-associated molecular patterns and damage-associated molecular patterns to activate innate immune signaling events, such as bursts of reactive oxygen species (ROS). (plantphysiol.org)
  • 2010). Inflammation is associated with increased generation of reactive oxygen-and nitrogen species (ROS/RNS), which is thought to play an important role in the inflammatory process and to contribute to tissue damage. (thefreelibrary.com)
  • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. (diabetesjournals.org)
  • Recent studies have revealed that vascular cells can produce reactive oxygen species (ROS) through NAD(P)H oxidase, which may be involved in vascular injury. (diabetesjournals.org)
  • We previously proposed that the production of hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) is a key event in the development of diabetes complications. (diabetesjournals.org)
  • We previously demonstrated that hyperglycemia induced production of reactive oxygen species (ROS) to be abrogated by inhibitors of the mitochondrial metabolism or by an overexpression of uncoupling protein (UCP)-1 or manganese superoxide dismutase (MnSOD) in both bovine aortic endothelial cells ( 6 ) and human mesangial cells ( 7 ). (diabetesjournals.org)
  • Therefore, development of innovative chemotherapeutic strategies is imperative, and a recent genomic analysis suggested the potential efficacy of reactive oxygen species (ROS)-inducing agents. (aacrjournals.org)
  • This effect has been proposed to relate to changes in intracellular reactive oxygen species. (aacrjournals.org)
  • These studies suggest that 4-HPR may effect changes in caspase 3 activity by modulating changes in zymogen stability by a mechanism distinct from the retinoid-elicited increase in reactive oxygen species. (aacrjournals.org)
  • Wheat Stripe Rust Resistance Protein WKS1 Reduces the Ability of the Thylakoid-Associated Ascorbate Peroxidase to Detoxify Reactive Oxygen Species. (jic.ac.uk)
  • Based on these results, we propose that the phosphorylation of tAPX by WKS1.1 reduces the ability of the cells to detoxify reactive oxygen species and contributes to cell death. (jic.ac.uk)
  • Furthermore, BA induces the formation of reactive oxygen species that are essential for BA-triggered cell death. (aspetjournals.org)
  • The generation of reactive oxygen species is blocked by BCL-2 and requires new protein synthesis but is unaffected by caspase inhibitors, suggesting that BA toxicity sequentially involves new protein synthesis, formation of reactive oxygen species, and activation of crm-A-insensitive caspases. (aspetjournals.org)
  • We find that BA-induced apoptosis of glioma cells is characterized by a sequential requirement for new protein, but not RNA, synthesis, generation of reactive oxygen species, and caspase processing associated with poly(ADP-ribose)polymerase cleavage. (aspetjournals.org)
  • The present study examined the effects of quinalizarin on the induction of cell cycle arrest, apoptosis, the generation of reactive oxygen species (ROS), other underlying mechanisms, and its role in modifying colorectal cancer cell lines. (medscimonit.com)
  • At a molecular level, DPP-23 targeted the unfolded protein response (UPR) in the endoplasmic reticulum (ER) through the production of reactive oxygen species (ROS) in cancer cells, but not in normal cells, resulting in selective killing of tumor cells via caspase-dependent apoptosis. (aacrjournals.org)
  • The present study synthesized a novel polyphenol conjugate (DPP-23) that produces reactive oxygen species (ROS) in a cancer-selective manner, leading to the stimulation of the unfolded protein response (UPR) and caspase-dependent apoptosis. (aacrjournals.org)
  • Reactive oxygen and nitrogen species induce protein and DNA modificati" by Theresa A Freeman, Javad Parvizi et al. (jefferson.edu)
  • Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty. (jefferson.edu)
  • The hypothesis for this study was that disregulated production of reactive oxygen species (ROS) and nitrogen species (RNS) mediates matrix protein and DNA modifications, which result in excessive fibroblastic proliferation. (jefferson.edu)
  • Reactive oxygen species (ROS) are highly reactive chemical molecules formed due to the electron receptivity of O2. (wikipedia.org)
  • The breakdown of glucose produces reactive oxygen species (ROS). (wikipedia.org)
  • A set of naturally occurring immunoglobulin M (IgM) antibodies that are reactive with a defined subset of proteins in the acrosomal cap region of human sperm has been identified. (sciencemag.org)
  • The subset of proteins with which the IgM antibodies are reactive includes a factor (or factors) capable of inhibiting lectin-induced T-lymphocyte proliferation. (sciencemag.org)
  • The prevalence of the sperm-reactive IgM antibodies indicates that they are not elicited by sperm. (sciencemag.org)
  • Further, immunoreactivity of the sperm proteins resulting in depletion of specific circulating IgM antibodies, or other interactions between the sperm proteins and elements of the immune system, may be a factor in the suppressed state of the immune system in AIDS. (sciencemag.org)
  • It contains NS0-expressed recombinant human CRP and antibodies raised against the recombinant protein. (rndsystems.com)
  • The indirect effects are more often pronounced, including elevation of inflammatory mediators with proinflammatory, procoagulant, and atherogenic action, production of cross-reactive antibodies, as well as nutrient/vitamin malabsorption and metabolic disturbances such as overproduction of ammonia by the bacterium. (medsci.org)
  • Previously, we showed that monoclonal myelin basic protein (MBP)-specific antibodies from MS patients cross-react with Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1). (frontiersin.org)
  • We suggest that induction of MBP-reactive antibodies in LMP1-immunized mice may be caused by either Follicular dendritic cells (FDCs) or by T cells that are primed by myelin antigens directly in CNS. (frontiersin.org)
  • Our findings help to elucidate the still enigmatic link between EBV infection and MS development, suggesting that myelin-reactive antibodies raised as a response toward EBV protein LMP1 are not truly cross-reactive but are primarily caused by epitope spreading. (frontiersin.org)
  • This hypothesis suggests that B cells initially recruited to neutralize external pathogens after somatic mutations and maturation start to produce low-to-middle affinity cross-reactive antibodies able to recognize self-antigens. (frontiersin.org)
  • For the generation of peptide and protein affinity columns, for the purification of antibodies and for the discovery of important interacting proteins and cofactors, G-Biosciences offers activated agarose for the coupling of peptides and proteins to agarose through their primary amines. (gbiosciences.com)
  • A low-molecular-weight recombinant Brucella abortus protein reactive with antibodies from a variety of naturally and experimentally infected hosts and T lymphocytes from experimentally infected mice was identified and given the designation BA14K. (asm.org)
  • High sensitivity C-reactive protein and cardiovascular risk prediction. (springer.com)
  • The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that finds lower levels of C-reactive protein (CRP). (healthlinkbc.ca)
  • Overweight and obese women who walked an average of 12,323 steps per day improved body weight, BMI, and lowered high-sensitivity C-reactive protein. (greenmedinfo.com)
  • The study aimed to investigate whether elevated plasma high sensitivity C-reactive protein (hs-CRP) levels are independently associated with an increased risk of cardiovascular disease (CVD) and to then assess the effectiveness of the addition of hs-CRP testing to cardiovascular risk assessment by standard lipid screening. (uwi.edu)
  • Asthma is characterised by chronic inflammation of the airways, but the relevance of high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in asthma. (ersjournals.com)
  • In conclusion, an increase in serum C-reactive protein levels measured by high-sensitivity assays may be associated with airflow obstruction and airway inflammation, and may serve as a surrogate marker of airway inflammation in asthma. (ersjournals.com)
  • This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). (medsci.org)
  • We present a wash-free high-sensitivity immunoassay of C-reactive proteins with droplet microfluidics. (rsc.org)
  • The limit of detection determined by our platform is 0.01 μg mL −1 , which is ten times more sensitive than conventional high-sensitivity C-reactive protein assays. (rsc.org)
  • The C‐Reactive Protein (High Sensitivity, Cardiac) (CRP) is a blood test that measures the amount of protein (called C‐reactive Protein) in your blood that indicates inflammation. (anylabtestnow.com)
  • With the C‐Reactive Protein (High Sensitivity, Cardiac) Test, you'll know if inflammation has damaged the inner lining of your arteries, thus increasing your chances of a heart attack. (anylabtestnow.com)
  • Abstract Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. (ahajournals.org)
  • Our findings identify oxidative damage to an important DNA replication and repair protein as a previously unrecognized hazard of acute oxidative stress. (open.ac.uk)
  • Many scientists believe that C-reactive proteins also help general immunity by suppressing early signs of infection. (brighthub.com)
  • C-reactive protein (CRP) is an acute phase reactant , a protein made by the liver that is released into the blood within a few hours after tissue injury, the start of an infection or other inflammation . (labtestsonline.org.uk)
  • C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. (frontiersin.org)
  • CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of inflammation and infection into five separate monomers, termed monomeric CRP (mCRP). (frontiersin.org)
  • C-reactive protein is a homopentameric acute-phase inflammatory protein, a highly conserved plasma protein that was initially discovered in 1930 by Tillet and Francis while investigating the sera of patients suffering from the acute stage of Pneumococcus infection and was named for its reaction with the capsular (C)-polysaccharide of Pneumococcus ( 1 ). (frontiersin.org)
  • C-reactive protein exhibits elevated expression during inflammatory conditions such as rheumatoid arthritis, some cardiovascular diseases, and infection ( 6 ). (frontiersin.org)
  • Diagnostic efficacy of serum procalcitonin, C-reactive protein concentration and clinical pulmonary infection score in Ventilator-Associated Pneumonia. (bioportfolio.com)
  • The aim of this study was to evaluate the diagnostic efficacy of serum procalcitonin (PCT), c-reactive protein (CRP) concentration and clinical pulmonary infection score(CPIS) in ventilator-associated. (bioportfolio.com)
  • To compare the value of Procalcitonin (PCT) as a marker of surgical site infection to other inflammatory markers, including C-Reactive Protein (CRP), White Cell Count (WCC) and Erythrocyte Sedimentati. (bioportfolio.com)
  • Serial C-Reactive Protein Measurements in Newborn Infants without Evidence of Early-Onset Infection. (bioportfolio.com)
  • C-reactive protein (CRP) is used to assist the diagnosis and monitoring of newborn infection. (bioportfolio.com)
  • CRP is a nonspecific, acute-phase protein produced by the liver in response to inflammation, infection, and tissue damage ( 6 ). (aacrjournals.org)
  • 9. Eckersall P D 2000 Acute phase proteins as markers of infection and inflammation: monitoring animal health, animal welfare and food safety. (scielo.org.za)
  • The human antibody response to flavivirus infection is dominantly directed against a cross-reactive epitope on the fusion loop of domain II (DII-FL) of the envelope (E) protein. (asm.org)
  • OBJECTIVE To evaluate diagnostic markers of infection in critically ill children, comparing procalcitonin with C reactive protein and leucocyte count in a paediatric intensive care unit (PICU). (bmj.com)
  • CONCLUSION In critically ill children the admission procalcitonin concentration is a better diagnostic marker of infection than C reactive protein or leucocyte count. (bmj.com)
  • 2-6 Although laboratory markers of infection might aid in differentiating the type of infection in infants and children, opinions vary on the interpretation of tests such as the leucocyte count, neutrophil count, band cell count, and C reactive protein concentration. (bmj.com)
  • We aimed to investigate the relationship between levels of serum C-reactive protein (hs-CRP) and the presence of coronary artery disease (CAD) in Iranian patients undergoing coronary angiography. (unboundmedicine.com)
  • Study of serum C-reactive protein concentration in cardiac failure. (bmj.com)
  • The serum concentration of C-reactive protein was prospectively assessed in 37 patients with various degrees of heart failure. (bmj.com)
  • The serum concentration of C-reactive protein was higher than normal in 26 (70%) patients. (bmj.com)
  • Heart failure is an additional cause of raised serum concentration of C-reactive protein but the pathological importance of this feature is not yet known. (bmj.com)
  • To examine the association between serum c-reactive protein (CRP) concentration and the metabolic syndrome (MS) using the International Diabetes Federation Metabolic Syndrome Guidelines (April, 2005) definition in an older Chinese population. (nih.gov)
  • C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. (springer.com)
  • Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome. (unboundmedicine.com)
  • Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia. (springer.com)
  • C-reactive protein and procalcitonin profile in ventilator-associated lower respiratory infections. (bioportfolio.com)
  • The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. (bioportfolio.com)
  • Comparison of procalcitonin, a potentially new inflammatory biomarker of frailty, to interleukin-6 and C-reactive protein among older Chinese hospitalized patients. (bioportfolio.com)
  • To predict the prognosis by observing the dynamic change of C-reactive protein (CRP) and procalcitonin (PCT) for hospitalized community-acquired pneumonia (CAP). (bioportfolio.com)
  • The main objective of this clinical study is to determine the normal reference range of the Nanōmix eLab® (eLab) C-Reactive Protein, Procalcitonin and Lactate Assay, whereby collected bl. (bioportfolio.com)
  • In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic. (bioportfolio.com)
  • Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein. (bioportfolio.com)
  • METHODS Procalcitonin, C reactive protein, and leucocyte count were measured in 175 children, median age 16 months, on admission to the PICU. (bmj.com)
  • Area under the ROC curve was 0.96 for procalcitonin, 0.83 for C reactive protein, and 0.51 for leucocyte count. (bmj.com)
  • Several authors have postulated that procalcitonin measurement might be superior to commonly used tests, such as C reactive protein measurement, as an aid to the early diagnosis of childhood bacterial sepsis. (bmj.com)
  • CRP is a highly reactive protein that is found when there is general inflammation within the body. (medicinenet.com)
  • This makes the protein structure vulnerable to glycosylation from galactose, glucose, mannose or sialic acid. (brighthub.com)
  • Three thousand and fourteen men and 7275 women aged 50-85 years were recruited and received a full medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein. (nih.gov)
  • In addition, the normalization of the mitochondrial ROS (mtROS) production by each of these agents prevents the glucose-induced activation of protein kinase C, the formation of advanced glycation end products, and the accumulation of sorbitol in bovine vascular endothelial cells, all of which are known to be involved in development of diabetes complications ( 6 ). (diabetesjournals.org)
  • A subsequent lumbar puncture of clear colourless fluid showed red blood count 200 mm -3 , WBC 312 mm -3 (90% neutrophils), glucose 2.7 mmol.l -1 , protein 2125 mg.l -1 , and was negative for meningococcal, Haemophilus influenzae and pneumococcal antigens (delayed culture negative). (bmj.com)
  • Overexpression of FLICE-inhibitory protein (FLIP) or B-cell lymphoma-2, which are known inhibitors of the extrinsic and intrinsic death pathways, respectively, similarly inhibited apoptosis by LF. (cdc.gov)
  • BA-induced apoptosis requires new protein, but not RNA, synthesis, is independent of p53, and results in p21 protein accumulation in the absence of a cell cycle arrest. (aspetjournals.org)
  • Drugs reported to induce apoptosis in glioma cells not only include common cancer chemotherapy drugs such as N,N ′-bis(2-chloroethyl)- N -nitrosourea and cisplatin but also several drugs that, among other actions, interfere with the activation of protein kinase C, including staurosporine, calphostin C, hypericin, and the hydroxy-methylglutaryl-CoA reductase inhibitor, lovostatin. (aspetjournals.org)
  • The apoptosis-related protein expression levels of p-p53, Bad, cleaved caspase-3, cleaved PARP and p-JNK were increased in quinalizarin-treated cells, while protein expression levels Bcl-2, p-Akt, p-ERK, and p-STAT3 were decreased. (medscimonit.com)
  • MAP kinase pathways, apoptosis, response to unfolded protein). (ku.edu)
  • It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
  • In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)
  • In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than those previously in routine use, revealed that increased CRP values, even within the range previously considered normal, strongly predict future coronary events. (jci.org)
  • Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. (springer.com)
  • Patient's diets are based on the Japan Atherosclerosis Society Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascular Diseases, consisting of 25 kcal/kg of ideal body weight per day (60% of total energy as carbohydrates, 15-20% as protein, and 20-25% as fat with the ratio of polyunsaturated, monounsaturated, and saturated fatty acids being 3:4:3). (diabetesjournals.org)
  • Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided. (patents.com)
  • We studied the role of preoperative leukocyte count and C-reactive protein (CRP) measurements in the diagnosis of acute appendicitis in fertile-aged women with a clinical suspicion of acute appendicitis. (biomedsearch.com)
  • First identified by William Tillett and Thomas Frances in 1930, C-reactive proteins were named after a type of streptococcus pneumoniae extract the team called "Fraction C." When the disease was administered, the two scientists found that the protein would react to fight against inflammation. (brighthub.com)
  • In 1930, C-reactive protein (CRP) was identified, it is a protein synthesized mainly by liver and adipose tissue, it is considered as acute phase protein increased in inflammatory and microbial invasion. (scirp.org)
  • Are elevated C-reactive protein (CRP) levels dangerous? (medicinenet.com)
  • This protein measures general levels of inflammation in your body. (healthlinkbc.ca)
  • The standard test measures high levels of the protein to find different diseases that cause inflammation. (healthlinkbc.ca)
  • Pre-operative C-reactive protein levels were independently associated with post-operative delirium. (greenmedinfo.com)
  • C-reactive protein ( CRP ) is an annular (ring-shaped), pentameric protein found in blood plasma , whose levels rise in response to inflammation . (wikidoc.org)
  • Periodontitis results in higher systemic levels of C-reactive protein, interleukin-6, total leukocyte count and neutrophils. (uwi.edu)
  • The aim of the present study is to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein (CRP), interleukin-6 (IL-6), total leukocyte count and differential count in patients with chronic periodontitis, in comparison to healthy individuals without periodontal disease. (uwi.edu)
  • Serum levels of the well-known inflammatory marker C-reactive protein (CRP) can be simply and inexpensively measured in order to assess systemic inflammation 1 . (ersjournals.com)
  • In terms of pro-inflammatory cytokine production, mCRP increases interleukin-8 and monocyte chemoattractant protein-1 production, whereas nCRP has no detectable effect on their levels. (frontiersin.org)
  • We monitored levels of C-reactive protein (CRP) in 96 consecutive adult allogeneic BMT patients (age 15-50 years) transplanted in our unit. (nature.com)
  • The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant. (bioportfolio.com)
  • CRP, C-reactive protein, is a pentameric protein found in the blood, the levels of which rise in response to inflammation, making CRP an acute-phase protein. (gbiosciences.com)
  • We also demonstrate the use of 4-fold multiplexing to enable relative protein measurements simultaneously with determination of absolute levels of a target protein using synthetic isobaric peptide standards. (mcponline.org)
  • An initial step in the systematic investigation of cellular processes is the identification and measurement of expression levels of relevant sets of proteins. (mcponline.org)
  • In this study, we make use of a 4-fold (4-plex) multiplex strategy to simultaneously determine relative protein levels in three yeast strains and provide a demonstration of the ability to measure the absolute quantity of specific target proteins through the use of internal peptide standards. (mcponline.org)
  • Myocardial mRNA levels of angiotensin type 1 receptor, atrial natriuretic factor, IL-6, GPx3, p47 phox , collagen-I, and transforming growth factor (TGF)-β1, the protein level of TGF-β1, and the numbers of Mac-2-positive macrophages and p-p65-positive cells were higher in TAC/CRPtg than in TAC/CON. (ahajournals.org)
  • There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. (diva-portal.org)
  • The Quantikine ® QuicKit™ Human C-Reactive Protein/CRP Immunoassay is a one step, 80-minute solid phase ELISA designed to measure human CRP levels in cell culture supernates, serum, and plasma. (rndsystems.com)
  • Can the c reactive protein ( crp) levels go up if you excercise? (healthtap.com)
  • Analysis of caspase 3 protein expression by Western blot analysis revealed that 4-HPR resulted in a significant increase in the appearance of the active p17 subunit without effecting a concomitant change in p32 procaspase 3 levels. (aacrjournals.org)
  • BA enhances the levels of BAX and BCL-2 proteins but does not alter the levels of BCL-x S or BCL-x L . Ectopic expression of BCL-2 prevents BA-induced caspase activation, DNA fragmentation, and cell death. (aspetjournals.org)
  • DC4 was the target of broadly cross-reactive and adhesion-inhibitory IgG Abs, and levels of DC4-specific and adhesion-inhibitory IgG increased with age among P. falciparum -exposed children. (jimmunol.org)
  • The global C-reactive protein (CRP) testing market is expected to register a CAGR of nearly 1.5% during the forecast period of 2018 - 2023. (marketresearch.com)
  • January, 2018 - Meso Scale Diagnostic Llc, received 510 (k) clearance from the US FDA for its conventional C-reactive protein assay for in vitro diagnostic use in the United States. (marketresearch.com)
  • Be the first to review Human C-Reactive Protein/CRP QuicKit ELISA and earn rewards! (rndsystems.com)
  • 8. Dillman R C, Coles E H 1966 A canine serum fraction analogous to human C-reactive protein. (scielo.org.za)
  • C-Reactive Protein antibody LS-C14638 is an unconjugated mouse monoclonal antibody to human C-Reactive Protein (CRP). (lsbio.com)
  • Reacts with Human C Reactive Protein. (lsbio.com)
  • Heat shock proteins (HSPs) function as an intracellular chaperonin for other proteins, and significant sequence homology is found between mammalian HSP and microbial HSP (Table 1 ). (hindawi.com)
  • They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein. (bioportfolio.com)
  • The oxidative/nitrosative modifications cause alterations in activities of intracellular effectors of MAPK- and PI3K/Akt-mediated signaling pathways, transcription factors (Nrf2, AP-1, NFκB, STAT3, and p53), components of ubiquitin/proteasomal and autophagy/lysosomal protein degradation systems, molecular chaperones, and cytoskeletal proteins. (aacrjournals.org)
  • Treatment with metformin and AICAR inhibited hyperglycemia-induced intracellular and mtROS production, stimulated AMP-activated protein kinase (AMPK) activity, and increased the expression of peroxisome proliferator-activated response-γ coactivator-1α (PGC-1α) and manganese superoxide dismutase (MnSOD) mRNAs. (diabetesjournals.org)
  • As a member of the pentraxin family, C-reactive proteins are bound together by calcium into a flattened structure. (brighthub.com)
  • [3] It is a member of the pentraxin family of proteins. (wikidoc.org)
  • Multiple 2-plex datasets can be combined after separate analyses, but there is a high likelihood that different sets of peptides and proteins will be identified between each experiment. (mcponline.org)
  • This guidance is intended to provide device manufacturers and FDA staff with updated recommendations concerning 510(k) submissions for various types of assays for C-Reactive Protein (CRP). (fda.gov)
  • The cloning and characterization of genes encoding immunoreactive Brucella proteins will provide a useful source of antigen for immunologic assays and subunit immunization studies. (asm.org)
  • Peripheral blood leukocytes were stimulated with human cytomegalovirus (HCMV), Chlamydia pneumoniae, human heat-shock protein 60 (hHSP60), or oxidized LDL (ox-LDL). (biomedsearch.com)
  • This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). (ovid.com)
  • Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count and erythrocyte sedimentation rate. (diabetesjournals.org)
  • A fertile-aged woman with right lower abdominal pain but unelevated leukocyte count and C-reactive protein. (biomedsearch.com)
  • Plaquenil has lowered SED rate and C reactive protein. (healthtap.com)
  • Blood samples were analysed at baseline and follow-up for the capacity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase and the inflammatory marker C-reactive protein (CRP). (thefreelibrary.com)
  • The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: a prospective cohort study. (thefreelibrary.com)
  • Rheumatoid arthritis (RA) is an inflammatory disease where activated cells release reactive oxygen substances. (thefreelibrary.com)
  • What does a high rheumatoid arthritis factor and c-reactive protein quantitative mean? (healthtap.com)
  • Search proteins in UniProtKB for this molecule. (uniprot.org)
  • Jialal's lab synthesized the CRP inhibitor, a peptide, which is a small protein molecule, by using the one-bead-one-compound combinatorial library ( http://bit.ly/14oGKR1 ) developed by study co-author Kit Lam , chair of the UC Davis Department of Biochemistry and Molecular Medicine and professor of hematology and oncology. (healthcanal.com)
  • 1. A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding C-reactive protein, wherein said compound is at least 90% complementary to a portion of said nucleic acid molecule encoding C-reactive protein, and wherein said compound inhibits the expression of C-reactive protein mRNA. (patents.com)
  • 12. The compound of claim 1 having at least 95%, at least 99% or 100% complementarity with said nucleic acid molecule encoding C-reactive protein. (patents.com)
  • Address correspondence to: Mark B. Pepys, Department of Medicine, Centre for Amyloidosis and Acute Phase Proteins, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom. (jci.org)
  • This article provides information about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases. (jci.org)
  • It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells . (wikidoc.org)
  • C-reactive protein (CRP) is an acute phase protein produced by hepatocytes and is a reliable marker of systemic inflammation. (nature.com)
  • The present study was performed to evaluate the usefulness of serum C-reactive protein (CRP) as an acute phase reactive protein in pet rabbits in clinical practice. (bva.co.uk)
  • C-reactive protein (CRP) is an acute phase reactant with a half-life as short as 19 hours. (hindawi.com)
  • The C-reactive protein (CRP), an acute phase reactant which binds selectively to T (thymus-derived) lymphocytes, was found to bind to lymphoblasts formed upon stimulation with antigens but not with mitogens. (sciencemag.org)
  • C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein that exhibits elevated expression during inflammation. (bl.uk)
  • C-reactive protein (CRP) (an acute phase protein) has been thought to be synthesised in the liver, with a plasma half-life of 18 hours. (scielo.org.za)
  • C-reactive protein, an abnormal protein absent from the blood of normal patients, appears as an acute phase response in a variety of clinical conditions, such as inflammation, neoplasia and granuloma formation. (annals.org)
  • C-reactive protein (CRP) is a positive major acute-phase protein in dogs and can be used as a predictive marker for risk of disease and to monitor the response to treatment. (scielo.org.za)
  • 6. Ceron J J, Eckersall P D, Martinez-Subiela A A 2005 Acute phase proteins in dogs and cats: current knowledge and future perspectives. (scielo.org.za)
  • Yue CC, Muller-Greven J, Dailey P, Lozanski G, Anderson V, Macintyre S. Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein within the endoplasmic reticulum. (springer.com)
  • After translation of input-strand RNA and viral replication, progeny virion assembly occurs within the endoplasmic reticulum (ER), with the capsid protein and genomic RNA associating with premembrane (prM) and envelope (E) proteins ( 42 ). (asm.org)
  • Immunologically reactive proteins of Streptococcus equi. (asm.org)
  • Immunologically reactive proteins in acid extracts and culture supernatants of Streptococcus equi were recognized through a combination of chromatographic and immunologic procedures. (asm.org)
  • This review focuses on the latest advancements evidencing that RONS-induced modifications of key redox-sensitive residues in regulatory proteins, that is, cysteine oxidation/S-sulfenylation/S-glutathionylation/S-nitrosylation and tyrosine nitration, represent important molecular mechanisms underlying carcinogenesis. (aacrjournals.org)
  • SDS-PAGE of the adsorbed TWPC showed greater intensity of [alpha]-la ([alpha]-lactalbumin) and the presence of high molecular -weight protein aggregates. (cornell.edu)
  • Both high- and low-molecular-weight components of each of these protein preparations were protective for mice and were, therefore, presumed to contain a variety of hydrolytic products or fragments of the M protein of S. equi. (asm.org)
  • Rabbit antisera to affinity-purified S. equi protein also reacted with these polypeptides, as well as with a polypeptide of about 36,000 to 37,000 molecular weight. (asm.org)
  • M protein in acid extract and culture supernatant did not cross-react in immunodiffusion, but rabbit antiserum to affinity-purified M protein from an acid extract of S. equi reacted strongly with culture supernatant proteins of approximate molecular weights of 67,000, 58,000, and 43,000. (asm.org)
  • One of these clones, which was designated IV-4, produced a recombinant Brucella protein with an apparent molecular mass of 14 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis. (asm.org)
  • The healthcare professionals have preference over other blood tests such as erythrocyte sedimentation rate (ESR) tests when compared to C-reactive protein testing, which impedes the growth of this market. (marketresearch.com)
  • Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins. (springer.com)
  • H 2 O 2 is readily converted into the aggressive hydroxyl radical by Fenton chemistry, and this extremely reactive radical could be responsible for much of the oxidative damage seen in all of the above disorders. (biochemsoctrans.org)
  • although the protein is not a specific antibody, it precipitates in vitro the C polysaccharide present in all types of pneumococci. (drugs.com)
  • Because C-reactive proteins act as a marker of inflammation, analysis of blood samples reveal the level of the proteins. (brighthub.com)
  • Therefore, we simultaneously measured effects of EPA on C-reactive protein (CRP), a marker of inflammation, and examined how alteration of lipoprotein profiles by EPA affects systemic inflammation. (diabetesjournals.org)
  • This approach for carrying out immunoassays can potentially be applied to other biomarkers beyond C-reactive proteins. (rsc.org)
  • In an attempt to identify Brucella proteins capable of inducing protective immune responses, a collection of recombinant Escherichia coli clones expressing Brucella proteins reactive in immunoassays with sera from a variety of experimentally and naturally infected hosts was assembled ( 18 ). (asm.org)
  • There is an urgent need to develop inhibitors that specifically block the biological effects of C-reactive protein," said Ishwarlal Jialal , senior author of the article and professor of pathology and laboratory medicine at UC Davis. (healthcanal.com)
  • C-reactive protein (224 aa, ~25 kDa) is encoded by the human CRP gene. (fpnotebook.com)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • The gene encoding BA14K was cloned and characterized, and the predicted amino acid sequence of this immunoreactive protein showed no significant homology with previously described proteins. (asm.org)
  • Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
  • This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. (wikipedia.org)
  • Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. (ku.edu)
  • However, a similar analysis of the directlyinteracting partners of 28 common targets of multiple reactive metabolites revealed highly significant enrichments in terms likely to be highly relevant to cytotoxicity (e.g. (ku.edu)
  • We tested the hypothesis that high serum concentrations of the n-3 PUFAs are associated with lower serum C-reactive protein (CRP) concentrations in healthy middle-aged Finnish men. (nature.com)
  • Compared to non-texturized WPC, TWPC formed stable oil-in-water emulsions at lower protein concentrations. (cornell.edu)
  • Tyrosine kinase substrate (Tks) family adaptor proteins have now been identified as Nox organizer proteins that enhance the production of ROS at invadopodia and podosomes, which are subcellular adhesion structures associated with extracellular matrix degradation. (sciencemag.org)
  • Treatment of the cells for 3 h with phorbol myristic acid (PMA), a protein kinase C (PKC) activator, also increased free radical production. (diabetesjournals.org)
  • After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
  • Recent rapid progress in reactive metabolite target protein identification has shown that adduction is surprisingly selective and inspired the hope that analysis of target proteins might reveal protein factors that differentiate target- vs. non-target proteins and illuminate mechanisms connecting covalent binding to cytotoxicity. (ku.edu)
  • The use of reactive dyes in biotechnology has burgeoned over the last two decades with the development of new ways of exploiting conventional textile dyes for the purification and analysis of proteins. (springer.com)
  • Immobilized p-Aminophenyl Phosphoryl Choline consists of a phosphoryl choline covalently linked to beaded agarose and is designed for the purification of C-reactive protein from plasma, ascites and other biological fluids. (gbiosciences.com)
  • Chronic accumulation of oxidized proteins is linked to neurodegenerative disorders and ageing. (open.ac.uk)
  • We suggest that the formation of a redox-active complex involving the relevant amyloidogenic protein and certain transition-metal ions could play an important role in the pathogenesis of several different protein misfolding disorders. (biochemsoctrans.org)
  • This study investigated the level of plasma hypoxia-inducible factor (HIF)-1α and cytochrome c (CytoC) in correlation with C-reactive protein, dyslipidaemia, insulin resistance, and prognostic factors in Type 2 diabetic patients in Saudi Arabia. (uwi.edu)
  • Interrelatedness between C-reactive protein and oxidized low-density lipoprotein. (springer.com)
  • an elevated c reactive protein is an indicator of inflammation in your body . (healthtap.com)
  • I have had my c-reactive protein and SED rate (both non-specific markers) measured during various work-ups by other doctors (neuro, rheum) and they were sometimes high. (medhelp.org)
  • Several cross-sectional and cohort studies have reported an association between serum markers of inflammation such as C-reactive protein, and coronary heart disease in Caucasian populations. (unboundmedicine.com)
  • The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. (bioportfolio.com)
  • Studies employing both purified subunit preparations and live, recombinant antigen delivery systems should allow a comprehensive evaluation of the relative importance of specific Brucella proteins in eliciting protective immunity. (asm.org)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • This uses the method of adding an enzyme to the blood that allows physicians to detect the amount of proteins present. (brighthub.com)
  • Microbeads are encapsulated within droplets for the immunoassay, and the droplets are scanned by a fluorescence detection platform to quantify the amount of proteins captured on the microbeads. (rsc.org)