C reactive protein. Medical search

A plasma protein that circulates in increased amounts during inflammation and after tissue damage.

Measurement of rate of settling of erythrocytes in anticoagulated blood.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.

An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.

An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.

A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.

Drugs that are used to treat RHEUMATOID ARTHRITIS.

Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.

A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease outcome.

Infections by bacteria, general or unspecified.

Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.

A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.

Disease having a short and relatively severe course.

A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.

Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)

A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)

An abnormal elevation of body temperature, usually as a result of a pathologic process.

A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.

The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

An infant during the first month after birth.

INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

Elements of limited time intervals, contributing to particular results or situations.

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

Substances that reduce or suppress INFLAMMATION.

Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

Antibodies produced by a single clone of cells.

An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.

A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)

An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)

Therapy with two or more separate preparations given for a combined effect.

Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The sum of the weight of all the atoms in a molecule.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/7727)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted. (+info)

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (2/7727)

BACKGROUND: In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability. METHODS AND RESULTS: We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (>3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP <3 mg/L but 69% of those with elevated CRP (P<0.001) were readmitted because of recurrence of instability or new myocardial infarction. New phases of instability occurred in 13% of patients in the lower tertile of CRP (/=8.7 mg/L, P<0.001). The prognostic value of SAA was similar to that of CRP; that of fibrinogen was not significant. Chlamydia pneumoniae but not Helicobacter pylori antibody titers significantly correlated with CRP plasma levels. CONCLUSIONS: In unstable angina, CRP may remain elevated for at >/=3 months after the waning of symptoms and is associated with recurrent instability. Elevation of acute-phase reactants in unstable angina could represent a hallmark of subclinical persistent instability or of susceptibility to recurrent instability and, at least in some patients, could be related to chronic Chlamydia pneumoniae infection. (+info)

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. (3/7727)

Criteria of the systemic inflammatory response syndrome (SIRS) are known to include patients without systemic inflammation. Our aim was to explore additional markers of inflammation that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1beta, tumour necrosis factor-alpha and C-reactive protein were determined, and severity of inflammation was evaluated by systemic inflammation composite score based on CD11b expression, C-reactive protein and cytokine levels. Levels of CD11b expression, C-reactive protein and interleukin-6 were higher in sepsis patients than in SIRS patients who met two criteria (SIRS2 group) or three criteria of SIRS (SIRS3 group). The systemic inflammation composite score of SIRS2 patients (median 1.5; range 0-8, n=56) was lower than that of SIRS3 patients (3.5; range 0-9, n=14, P=0.013) and that of sepsis patients (5.0; range 3-10, n=19, P<0.001). The systemic inflammation composite score was 0 in 13/94 patients. In 81 patients in whom systemic inflammation composite scores exceeded 1, interleukin-6 was increased in 64 (79.0%), C-reactive protein in 59 (72.8%) and CD11b in 50 (61.7%). None of these markers, when used alone, identified all patients but at least one marker was positive in each patient. Quantifying phagocyte CD11b expression and serum interleukin-6 and C-reactive protein concurrently provides a means to discriminate SIRS patients with systemic inflammation from patients without systemic inflammation. (+info)

Socioeconomic status and determinants of hemostatic function in healthy women. (4/7727)

Hemostatic factors are reported to be associated with coronary heart disease (CHD). Socioeconomic status (SES) is 1 of the determinants of the hemostatic profile, but the factors underlying this association are not well known. Our aim was to examine determinants of the socioeconomic differences in hemostatic profile. Between 1991 and 1994, we studied 300 healthy women, aged 30 to 65 years, who were representative of women living in the greater Stockholm area. Fibrinogen, factor VII mass concentration (FVII:Ag), activated factor VII (FVIIa), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1) were measured. Educational attainment was used as a measure of SES. Low educational level and an unfavorable hemostatic profile were both associated with older age, unhealthful life style, psychosocial stress, atherogenic biochemical factors, and hypertension. Levels of hemostatic factors increased with lower educational attainment. Independently of age, the differences between the lowest (mandatory) and highest (college/university) education in FVII:Ag levels were 41 microg/L (95% confidence interval [CI], 15 to 66 microg/L, P=0.001), 0.26 g/L (95% CI, 0.10 to 0.42 g/L, P=0.001) in fibrinogen levels, and 0.11 U/mL (95% CI, 0.09 to 0.12 U/mL, P=0.03) in levels of vWF. The corresponding differences in FVIIa and PAI-1 were not statistically significant. With further adjustment for menopausal status, family history of CHD, marital status, psychosocial stress, lifestyle patterns, biochemical factors, and hypertension, statistically significant differences between mandatory and college/university education were observed in FVII:Ag (difference=34 microg/L; 95% CI, 2 to 65 microg/L, P=0.05) but not in fibrinogen (difference=0.03 g/L; 95% CI, -0.13 to 0.19 g/L, P=0.92) or in vWF (difference=0.06 U/mL; 95% CI, -0.10 to 0.22 U/mL, P=0.45). An educational gradient was most consistent and statistically significant for FVII:Ag, fibrinogen, and vWF. Age, psychosocial stress, unhealthful life style, atherogenic biochemical factors, and hypertension mediated the association of low educational level with elevated levels of fibrinogen and vWF. Psychosocial stress and unhealthful life style were the most important contributing factors. There was an independent association between education and FVII:Ag, which could not be explained by any of these factors. (+info)

Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study. (5/7727)

BACKGROUND: Chlamydia pneumoniae commonly causes respiratory infection, is vasotropic, causes atherosclerosis in animal models, and has been found in human atheromas. Whether it plays a causal role in clinical coronary artery disease (CAD) and is amenable to antibiotic therapy is uncertain. METHODS AND RESULTS: CAD patients (n=302) who had a seropositive reaction to C pneumoniae (IgG titers >/=1:16) were randomized to receive placebo or azithromycin, 500 mg/d for 3 days, then 500 mg/wk for 3 months. Circulating markers of inflammation (C-reactive protein [CRP], interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha), C pneumoniae antibody titers, and cardiovascular events were assessed at 3 and 6 months. Treatment groups were balanced, with age averaging 64 (SD=10) years; 89% of the patients were male. Azithromycin reduced a global rank sum score of the 4 inflammatory markers at 6 (but not 3) months (P=0. 011) as well as the mean global rank sum change score: 531 (SD=201) for active drug and 587 (SD=190) for placebo (P=0.027). Specifically, change-score ranks were significantly lower for CRP (P=0.011) and IL-6 (P=0.043). Antibody titers were unchanged, and number of clinical cardiovascular events at 6 months did not differ by therapy (9 for active drug, 7 for placebo). Azithromycin decreased infections requiring antibiotics (1 versus 12 at 3 months, P=0.002) but caused more mild, primarily gastrointestinal, adverse effects (36 versus 17, P=0.003). CONCLUSIONS: In CAD patients positive for C pneumoniae antibodies, global tests of 4 markers of inflammation improved at 6 months with azithromycin. However, unlike another smaller study, no differences in antibody titers and clinical events were observed. Longer-term and larger studies of antichlamydial therapy are indicated. (+info)

Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. (6/7727)

BACKGROUND: The benefits of near-patient, point-of-care tests have not been fully examined. We have assessed the clinical, organizational, and economic outcomes of implementing a near-patient test for C-reactive protein (CRP) in general practice. METHODS: In a randomized crossover trial during intervention periods, general practitioners (GPs) were allowed to measure CRP within 3 min, using NycoCard(R) CRP. During control periods, they had to mail blood samples for CRP measurements to the hospital laboratory and received test results 24-48 h later. Twenty-nine general practice clinics participated (64 GPs), and 1853 patients were included in the study. Results were evaluated at both the level of participating GPs and the level of included patients. RESULTS: For participating GPs, the overall use of erythrocyte sedimentation rates (ESRs) decreased by 8% (95% confidence interval, 1-14%) during intervention periods, and the number of blood samples mailed to the hospital laboratory decreased by 6% (1-10%). No reduction in the prescription of antibiotics was seen. The proportion of study patients having a follow-up telephone consultation was reduced from 63% to 53% (P = 0. 0001), and patients with CRP concentrations >50 mg/L had their antibiotic treatments started earlier when CRP was measured in general practices (P = 0.0161). CONCLUSION: The implementation of the near-patient CRP test was cost-effective mainly on the basis of a reduction in the use of services from the hospital laboratory by GPs. If the implementation is followed by education and clinical guidelines, opportunities exist for additional reduction in the use of ESR and for a more appropriate use of antibiotics. (+info)

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (7/7727)

BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection. (+info)

Leptin elimination in hyperleptinaemic peritoneal dialysis patients. (8/7727)

BACKGROUND: Elevated plasma concentrations of leptin, a hormone thought to regulate body composition by influencing food intake/metabolic rate, are prevalent in renal failure patients. The mechanism for these increases is not known, but evidence suggests that simple accumulation due to decreased elimination is insufficient explanation. METHODS: We studied the incidence of hyperleptinaemia in 28 end-stage renal disease patients treated with continuous ambulatory peritoneal dialysis (CAPD), compared with body-mass-index-and sex-matched controls. Results were separated by gender because women have higher leptin concentrations than men. Excretion of leptin and other substances in dialysis fluid was also studied. RESULTS: Hyperleptinaemia was prevalent in women CAPD subjects, but not in men. Plasma leptin concentrations correlated strongly with the daily excretion of leptin in dialysis fluid. Clearance of leptin in dialysis fluid was greater in men than women CAPD subjects. Single regression analysis found that fasting insulin, glucose content of dialysis fluid, plasma albumin, C-reactive protein, erythropoietin dose, urinary creatinine clearance and plasma beta2-microglobulin were not determinants of plasma leptin concentrations. Stepwise forward multiple regression, examining the dependence of plasma leptin on body mass index, renal creatinine clearance, plasma albumin, daily dialysis fluid glucose load, daily leptin in dialysis fluid, erythropoietin dose and plasma C-reactive protein found only erythropoietin dose as a consistent negative predictor of plasma leptin concentrations. CONCLUSIONS: The results suggest that hyperleptinaemia of CAPD was due to predisposing loss of renal elimination capacity combined with increased production due to obesity (more prevalent in women subjects of this study) and potentially female gender. (+info)

MedlinePlus Encyclopedia: C-reactive protein Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein (American ... CAA39671". NCBI Entrez Protein. "Human C-reactive protein complexed with phosphocholine". Protein Data Bank in Europe. Enocsson ... Helal I, Zerelli L, Krid M, Kheder A (2012). "Comparison of C-reactive protein and high-sensitivity C-reactive protein levels ... acute phase erythrocyte sedimentation rate C-reactive protein C-reactive protein GRCh38: Ensembl release 89: ENSG00000132693 - ...

https://en.wikipedia.org/wiki/C-reactive_protein

... causing oxidized protein levels to increase. This led researchers to conclude that oxidation of cellular proteins is ... stress Oxygen toxicity Pro-oxidant Reactive nitrogen species Reactive sulfur species Reactive carbonyl species Reactive oxygen ... In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (O2). Examples of ROS ... The sulfur contained in these enzymes acts as the reactive center, carrying reactive electrons from the peroxide to the ...

https://en.wikipedia.org/wiki/Reactive_oxygen_species

... s may be incorporated into proteins and peptides in vivo or in vitro. Photo-reactive amino acid ... They are then ultraviolet light (UV)-activated to covalently crosslink proteins within protein-protein interaction domains in ... Photo-reactive amino acid analogs are artificial analogs of natural amino acids that can be used for crosslinking of protein ... Naturally interacting proteins within the cell can be instantly trapped by photoactivation of the diazirine-containing proteins ...

https://en.wikipedia.org/wiki/Photo-reactive_amino_acid_analog

"DyLight Reactive Dyes". Pierce Protein Research Products. 2008. Retrieved 2013-10-17. "DyLight Reactive Dyes". Pierce Protein ... DyLight Fluors are commercially available as reactive succinimidyl-esters for labeling proteins through lysine residues, and as ... "Fisher Biosciences Collaborates with Dyomics to Add Fluorescent Reagents for Protein Research". Press release. BNET. 2006-01-09 ... Pierce Protein Research Products. 2011. Archived from the original on 2013-10-17. Retrieved 2013-10-17. " ...

https://en.wikipedia.org/wiki/DyLight_Fluor

"C-reactive protein". GPnotebook. 2730 Serum C-Reactive Protein values in Diabetics with Periodontal Disease Archived 2008-12-20 ... Acute phase proteins are markers of inflammation. Autoantibodies are usually absent or very low, so instead of being given in ... Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. Note: ... Electrolytes and metabolites: For iron and copper, some related proteins are also included. Cardiology diagnostic tests and ...

https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests

In the blood sample, clinicians will look at full blood count, C reactive protein, and blood culture. C-reactive protein levels ... Black S, Kushner I, Samols D (November 2004). "C-reactive Protein". The Journal of Biological Chemistry. 279 (47): 48487-48490 ...

https://en.wikipedia.org/wiki/Sucking_blister

... elevated C-reactive protein; failure to sterilize the CSF before immune recovery. IRIS may be the cause of paradoxically worse ... protein, glucose) increase. CSF culture is typically sterile, and there is no increase in CSF cryptococcal antigen titer. The ...

https://en.wikipedia.org/wiki/Immune_reconstitution_inflammatory_syndrome

Drahl, C.; Cravatt, B. F.; Sorensen, E. J. (2005). "Protein-reactive natural products". Angew. Chem. Int. Ed. Engl. 44 (36): ... There, the cargo will be released when the Ran-GTP protein is hydrolyzed by a cytoplasmic Ran-GTPase enzyme to form Ran-GDP. ... These molecules include regulatory proteins such as Rev, MAPK/MEK1, c-Abl, Cyclin B1, MDM2/p53, IkB, MPF, and PKA. The most ... The acyl groups are loaded onto the acyl carrier protein (ACP) with the help of the acyltransferase (AT) domain. Each module ...

https://en.wikipedia.org/wiki/Callystatin_A

... such as a high-sensitivity C-reactive protein test (CRP) measuring CRP, a protein in found in blood that indicates inflammation ... "C-reactive protein test". Mayo Clinic. Retrieved 2019-01-18. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, ...

https://en.wikipedia.org/wiki/BaleDoneen_Method

Cryptotope Epitope binning Mimotope Odotope Polyclonal B cell response Protein tag TimeSTAMP protein labelling Mahmoudi Gomari ... Epitopes are sometimes cross-reactive. This property is exploited by the immune system in regulation by anti-idiotypic ... The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their ... Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of ...

https://en.wikipedia.org/wiki/Epitope

... protein kinase C, and other proteins that potentiate cytokine release and other aspects of inflammation. Binding of RASP to ... Reactive aldehyde species (RASP), also known as reactive aldehydes, refer to a class of electrophilic organic aldehyde ... particularly in proteins. Following threshold amounts of binding to the electrophile-responsive proteome, RASP modify protein ... In addition to binding to proteins and other amine or thiol-containing molecules such as glutathione, RASP are metabolized by ...

https://en.wikipedia.org/wiki/Reactive_aldehyde_species

... triggers reactive oxygen species (ROS). ROS production disrupts protein folding and induces the unfolded protein ... This article incorporates text from the public domain Pfam and InterPro: IPR009990 (Protein families, Antimicrobial peptides). ...

https://en.wikipedia.org/wiki/Pardaxin

... damage or loss of vitamins and proteins; production of potential cancerogenic reactive radicals. In Australia, following cat ...

https://en.wikipedia.org/wiki/Radurization

... acid semialdehyde threonyl to amino ketobutyric acid Carbonylation is typically assumed to be the result of reactive oxygen ... Protein carbonylation refers to oxidation of protein side chains to introduce ketone- and aldehyde groups in a protein. The ... Protein carbonylation is of interest because of its association with various diseases. Oxidative stress, often metal catalyzed ... Grimsrud, P. A.; Xie, H.; Griffin, T. J.; Bernlohr, D. A. (2008). "Oxidative Stress and Covalent Modification of Protein with ...

https://en.wikipedia.org/wiki/Protein_carbonylation

C-reactive protein will be elevated. Liver function tests may show evidence of hepatic inflammation and low serum albumin ... Urinalysis may show white blood cells and protein in the urine (pyuria and proteinuria) without evidence of bacterial growth. ...

https://en.wikipedia.org/wiki/Kawasaki_disease

Peroxynitrite can react directly with proteins that contain transition metal centers. Therefore, it can modify proteins such as ... Reactive oxygen species Reactive sulfur species Reactive carbonyl species Novo E, Parola M (2008). "Redox mechanisms in hepatic ... Reactive nitrogen species act together with reactive oxygen species (ROS) to damage cells, causing nitrosative stress. ... Reactive nitrogen species are also continuously produced in plants as by-products of aerobic metabolism or in response to ...

https://en.wikipedia.org/wiki/Reactive_nitrogen_species

Paraskevas S, Huizinga JD, Loos BG (April 2008). "A systematic review and meta-analyses on C-reactive protein in relation to ... Periodontitis has been linked to increased inflammation in the body, such as indicated by raised levels of C-reactive protein ... Studies have confirmed an increase in systemic inflammation markers such as C-Reactive Protein and Interleukin-6 to be found in ... D'Aiuto F, Ready D, Tonetti MS (August 2004). "Periodontal disease and C-reactive protein-associated cardiovascular risk". ...

https://en.wikipedia.org/wiki/Periodontal_disease

... mediates suppression of C-reactive protein: Explanation for muted C-reactive protein response in lupus flares?". Arthritis & ... C-reactive protein (CRP) is an acute phase protein. Therefore, it is a better marker for acute phase reaction than ESR. While ... Arik N, Bedir A, Günaydin M, Adam B, Halefi I (October 2000). "Do erythrocyte sedimentation rate and C-reactive protein levels ... Falk, G.; Fahey, T. (2008). "C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of ...

https://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate

It is reactive toward DNA and proteins. ONOO− reacts nucleophilically with carbon dioxide. In vivo, the concentration of carbon ... Nitrotyrosine Reactive nitrogen species Bohle, D. Scott; Sagan, Elisabeth S. (2004). "Tetramethylammonium Salts of Superoxide ... Its conjugate acid peroxynitrous acid is highly reactive, although peroxynitrite is stable in basic solutions. ...

https://en.wikipedia.org/wiki/Peroxynitrite

Krev interaction trapped protein 1 is a protein that in humans is encoded by the CCM1 gene. This gene contains 16 coding exons ... KRIT1 has been shown to interact with multiple signaling pathways including; ITGB1BP1., reactive oxygen species, cell death, ... The normal CCM1 protein, KRIT1 (Krev Interaction Trapped), is 736 amino acids in length and has a variety of functions. ... Related to the CCM illness, this protein is required for maintaining the structural integrity of the vasculature. GRCm38: ...

https://en.wikipedia.org/wiki/KRIT1

"Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting ,". Macromolecular Rapid Communications. 41 (23): ... Though, smaller protein attachments are generally tolerated by protein NPs. A significant limitation to direct attachment via ... Protein nanotechnology is a burgeoning field of research that integrates the diverse physicochemical properties of proteins ... Due to the abundance of proteins necessary for proper bodily function, the body has developed processes to update proteins into ...

https://en.wikipedia.org/wiki/Protein_nanoparticles

Mitochondrial SNO-proteins inhibit Complex I of the electron transport chain; modulate mitochondrial reactive oxygen species ( ... Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (February 2005). "Protein S-nitrosylation: purview and parameters". Nat. ... Derakhshan B, Hao G, Gross SS (July 2007). "Balancing reactivity against selectivity: the evolution of protein S-nitrosylation ... It was particularly noteworthy that in cultured normal rat cholangiocytes, GSNO activated protein kinase B, protected against ...

https://en.wikipedia.org/wiki/S-Nitrosoglutathione

... is also used in protein crystallography. Applied at pressures from 0.5 to 5 MPa (5 to 50 atm) to a protein crystal, xenon ... ISBN 978-0-7803-8265-7. Staff (2007). "Neil Bartlett and the Reactive Noble Gases". American Chemical Society. Retrieved June 5 ... For instance, xenon dissolved in water, xenon dissolved in hydrophobic solvent, and xenon associated with certain proteins can ... Staff (December 21, 2004). "Protein Crystallography: Xenon and Krypton Derivatives for Phasing". Daresbury Laboratory, PX. ...

https://en.wikipedia.org/wiki/Xenon

NH3 is a building block to Amino acids and proteins amongst other things essential for life. However, just over half of all ... While reactive nitrogen is eventually converted back into molecular nitrogen via denitrification, an excess of reactive ... Reactive nitrogen ("Nr"), also known as fixed nitrogen, refers to all forms of nitrogen present in the environment except for ... In the environmental context, reactive nitrogen compounds include the following classes: oxide gases: nitric oxide, nitrogen ...

https://en.wikipedia.org/wiki/Reactive_nitrogen

Oxidation of cysteine residues in protein to the corresponding protein sulfenic acids is suggested to be important in redox- ... In contrast to sulfinic and sulfonic acids, simple sulfenic acids, such as methanesulfenic acid, CH3SOH, are highly reactive ... 2-Propenesulfenic and 2-Propenesulfinic Acids, Diallyl Trisulfane S-Oxide and Other Reactive Sulfur Compounds from Crushed ... Mansuy D, Dansette PM (2011). "Sulfenic acids as reactive intermediates in xenobiotic metabolism". Archives of Biochemistry and ...

https://en.wikipedia.org/wiki/Sulfenic_acid

Reactive and Functional Polymers 54, 37-47(2003). . E. Nagele, M. Vollmer, P. Horth, and C. Vad. 2D-LC/MS techniques for the ... For example, if there is any overlap between the displacer and the protein of interest, these low molecular mass materials can ... For some matrices, reactive groups on the stationary phase can be titrated to temporarily eliminate the binding sites, for ... There are several examples in which displacement chromatography has been applied to the purification of proteins using ion ...

https://en.wikipedia.org/wiki/Displacement_chromatography

July 2000). "Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes". The Journal ... Major urinary proteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and ... Along with other members of the lipocalin protein family, major urinary proteins can be potent allergens to humans. The reason ... February 2001). "Effect of polymorphisms on ligand binding by mouse major urinary proteins". Protein Science. 10 (2): 411-7. ...

https://en.wikipedia.org/wiki/Major_urinary_proteins

Reactive oxygen species, ROS, such as superoxide (O2- • ), hydrogen peroxide (H2O2), hydroxyl radicals (HO•), and singlet ... DNA repair protein XRCC4 also known as X-ray repair cross-complementing protein 4 or XRCC4 is a protein that in humans is ... Two XRCC4 proteins are post-translationally modified for recognition and localization to Ku70/80 (5). The two XRCC4 proteins ... The X-ray repair cross-complementing protein 4 is one of several core proteins involved in the non-homologous end joining (NHEJ ...

https://en.wikipedia.org/wiki/DNA_repair_protein_XRCC4

Cysteine is a very reactive amino acid that would not be tolerated in high numbers within a small region of a protein. ... heterologous protein expression, medicine, as well as to our understanding of protein evolution. LCRs of eukaryotic proteins ... Proteins with GO terms related to RNA binding and processing were enriched for arginine in their LCRs. Proteins with GO terms ... Proteins with GO terms related to protein folding were enriched for glycine, methionine and phenylalanine in their LCRs. Based ...

https://en.wikipedia.org/wiki/Low_complexity_regions_in_proteins

C-reactive protein is elevated in most cases. Prostate biopsies are not indicated as the (clinical) features (described above) ...

https://en.wikipedia.org/wiki/Acute_prostatitis

... is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... Barbas CF, Languino LR, Smith JW (November 1993). "High-affinity self-reactive human antibodies by design and selection: ... a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on ... characterize small molecules-protein interactions and map protein-protein interactions. Users can use three dimensional ...

https://en.wikipedia.org/wiki/Phage_display

Glial fibrillary acidic protein, enolase 2,Anti-NMDA receptor encephalitis. Inflammatory Biomarkers - c-reactive protein, ... Blood Biomarkers: Many proteins and RNA biomarkers identified are connected to ischemic stroke pathophysiology includes Central ... and the arrest of protein synthesis. Additionally, removal of metabolic wastes is slowed. The interruption of blood flow to the ...

https://en.wikipedia.org/wiki/Brain_ischemia

The breakdown of glucose produces reactive oxygen species (ROS). These induce extracellular Daxx to translocalize into the ... Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. Daxx, a Death domain- ... This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate ... It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor ...

https://en.wikipedia.org/wiki/Death-associated_protein_6

To prevent the salting out of proteins, H. salinarum encodes mainly acidic proteins. The average isoelectric point of H. ... It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target. The ... salinarum proteins is 5.03. These highly acidic proteins are overwhelmingly negative in charge and are able to remain in ... These proteins form a lattice in the membrane. Sulfate residues are abundant on the glycan chains of the glycoprotein, giving ...

https://en.wikipedia.org/wiki/Halobacterium_salinarum

... processes including oxidative phosphorylation and the formation of disulfide bonds during protein folding produce reactive ... Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. Many proteins are enzymes that catalyze ... In prokaryotes, these proteins are found in the cell's inner membrane. These proteins use the energy from reduced molecules ... Amino acids are made into proteins by being joined in a chain of peptide bonds. Each different protein has a unique sequence of ...

https://en.wikipedia.org/wiki/Metabolism

2004). "Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells". J. Biol. Chem. 279 ( ... 2004). "Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH ... Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer ... A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in ...

https://en.wikipedia.org/wiki/NOX4

Between 2% and 5% of T cells develop auto-reactive receptors. Most of these undergo negative selection by clonal deletion. T ... This helps eliminate autoreactive T cells that recognize a protein from a specific body part. Complete clonal deletion results ... Superantigens are composed of viral or bacterial proteins and can hijack the clonal deletion process when expressed in the ... Clonal deletion provides an incentive for microorganisms to develop epitopes similar to proteins found within the host. Because ...

https://en.wikipedia.org/wiki/Clonal_deletion

These adducts can further rearrange to form reactive species, which can then cross-link the structural proteins or DNA to ... Free radicals can damage proteins, lipids or DNA. Glycation mainly damages proteins. Damaged proteins and lipids accumulate in ... Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can ... Old animals have larger amounts of oxidized proteins, DNA and lipids than their younger counterparts. One of the earliest aging ...

https://en.wikipedia.org/wiki/Senescence

The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early ... Bellini A, Mattoli S (September 2007). "The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive ... Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (June 2001). "The adapter protein CrkL associates with CD34". Blood. 97 ... CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 ...

https://en.wikipedia.org/wiki/CD34

Of note, the L form of amino acids and the D form of sugars (primarily glucose) are usually the biologically reactive form. ... Protein structure, Post-translational modification). ... Likewise, the (S) stereoisomer is much more reactive than the ( ...

https://en.wikipedia.org/wiki/Racemization

Protein-protein interactions play a very important role in Na⁺-K⁺ pump-mediated signal transduction. For example, the Na⁺-K⁺ ... It also functions as a signal transducer/integrator to regulate the MAPK pathway, reactive oxygen species (ROS), as well as ... this membrane protein can also relay extracellular ouabain-binding signalling into the cell through regulation of protein ... A cell's osmolarity is the sum of the concentrations of the various ion species and many proteins and other organic compounds ...

https://en.wikipedia.org/wiki/Sodium–potassium_pump

His studies involve Reactive oxygen species, Inflammation, Small GTP-Binding Proteins, hypertrophy, hypertension and ...

https://en.wikipedia.org/wiki/Pascal_J._Goldschmidt

The strong immune reaction in response to exposure to the salivary protein indicates the protein's potential use in the field ... Heme acts as a toxic molecule that can generate oxygen-reactive species and bypass membranes due to its high permeability. ... The strong immune reaction in response to exposure to the salivary protein indicates the protein's potential use in the field ... Blood is rich in proteins, consisting mainly of hemoglobin (Hb), which accounts for approximately 60% of the blood protein ...

https://en.wikipedia.org/wiki/Lutzomyia_longipalpis

... higher levels of reactive oxygen species and increased oxidative stress. Mutant huntingtin protein promotes oxidative damage to ... mtDNA is packaged with proteins which appear to be as protective as proteins of the nuclear chromatin. Moreover, mitochondria ... InterMitoBase: an annotated database and analysis platform of protein-protein interactions for human mitochondria. (apparently ... an annotated database and analysis platform of protein-protein interactions for human mitochondria". BMC Genomics. 12: 335. doi ...

https://en.wikipedia.org/wiki/Mitochondrial_DNA

On a protein level, structure is less conserved than sequence. Therefore, in many diseases, having the faulty gene still does ... Predictive medicine changes the paradigm of medicine from being reactive to being proactive and has the potential to ...

https://en.wikipedia.org/wiki/Predictive_medicine

... must first be metabolized into its reactive electrophilic form, aflatoxin B1-8,9-exo-epoxide by cytochrome p450. ... us), National Center for Biotechnology Information (1998-01-01). The p53 tumor suppressor protein. National Center for ...

https://en.wikipedia.org/wiki/Aflatoxin_B1

... including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer, and ferritin. Systemic inflammation results ... nucleocapsid protein (N), and the spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat ... interferon gamma-induced protein 10 (IP‑10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1‑alpha ... The S-protein, otherwise known as the spike protein, is the viral component that attaches to the host receptor via the ACE2 ...

https://en.wikipedia.org/wiki/COVID-19

"Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with ... and protein/cell diagnostics (Abbott, BD, and Crescendo), predominantly focused on Oncology, Hematology, and Autoimmunity, ...

https://en.wikipedia.org/wiki/Oscar_Segurado

Chemically, silver is not very reactive-it does not react with oxygen or water at ordinary temperatures, so does not easily ... "Silver Ions Caused Faster Diffusive Dynamics of Histone-Like Nucleoid-Structuring Proteins in Live Bacteria". Applied and ...

https://en.wikipedia.org/wiki/Sterling_silver

Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T cell clones. Cell 36:879-888. Rao A, ... Analogues which compete for antigen binding to an arsonate-reactive T cell clone inhibit the functional response to arsonate. ...

https://en.wikipedia.org/wiki/Harvey_Cantor

The methodology is widely used for enzymatic synthesis of DNA or RNA-bearing fluorescent, redox, or reactive labels, as well as ... "Vinylsulfonamide and Acrylamide Modification of DNA for Crosslinking with Proteins". Angew. Chem. Int. Ed. 52 (40): 10515-10518 ...

https://en.wikipedia.org/wiki/Michal_Hocek

The condition results in abdominal pain, fever, elevated white blood cell count and elevated serum C-reactive protein. PPCS ... and elevated inflammatory markers such as C-reactive protein. CT scan of the abdomen may show severe mural thickening, without ...

https://en.wikipedia.org/wiki/Postpolypectomy_coagulation_syndrome

YopE GAP activity inhibits two common methods of host immunity - phagocytosis and reactive oxygen species generation. ... This particular protein domain can be referred to as a Rho GTPase-activating protein (GAP). YopE is an effector protein of the ... It functions as a Rho GTPase-activating protein (GAP). YopE acts as both a virulence factor and a protective antigen. In order ... Rosqvist R, Forsberg A, Rimpiläinen M, Bergman T, Wolf-Watz H (April 1990). "The cytotoxic protein YopE of Yersinia obstructs ...

https://en.wikipedia.org/wiki/YopE_protein_domain

It involves the generation of reactive oxygen species (ROS), which have crucial roles in signal transduction or as toxic agents ... These genes and their associated proteins are responsible for pathogen recognition and activation of defense signaling networks ... Chemi-excitation via oxidative stress by reactive oxygen species and/or catalysis by enzymes (i.e., peroxidase, lipoxygenase) ... Further support is provided by studies indicating that emission can be increased by addition of reactive oxygen species. ...

https://en.wikipedia.org/wiki/Biophoton

Both proteins are tetramer complexes with iron protein complexes called hemes built into each subunit of the tetramer. The ... Hydroxyl radicals and other reactive oxygen species when generated near DNA can cause point mutations, cross-linkage and breaks ... The calcium bound proteins usually play an important role in cell-cell adhesion, hydrolytic processes (such as hydrolytic ... Zinc is also used in a number of transcription factors, proteins and enzymes. Sodium is a metal where humans have discovered a ...

https://en.wikipedia.org/wiki/Biometal_(biology)

... protein)s. This results in the addition of the PG to the protein by a Michael addition reaction and important modifications in ... Carbon 9 thereby becomes chemically reactive as an electrophilic center. PGJ2 undergoes a spontaneous isomerization reaction in ... in diverse proteins. The reaction inactivates or reduces the activity of various functionally important target proteins and is ... The inhibition of protein translation can trigger programmed cell death responses while the sequestration of TRAF2 may suppress ...

https://en.wikipedia.org/wiki/Cyclopentenone_prostaglandins

One of the best-known families of porphyrin complexes is heme, the pigment in red blood cells, a cofactor of the protein ... These high reactive oxygen species react with susceptible cellular organic biomolecules such as; lipids, aromatic amino acids, ... This interaction produces the formation of a highly reactive oxygen species (ROS), usually singlet oxygen, as well as ... Huang X, Groves JT (March 2018). "Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins". ...

https://en.wikipedia.org/wiki/Porphyrin

The N-terminus of Histatin 5 allows it to bind with metals, and this can result in the production of reactive oxygen species. ... Histatins are antimicrobial and antifungal proteins, and have been found to play a role in wound-closure. A significant source ... The structure of histatin is unique depending on whether the protein of interest is histatin 1, 3 or 5. Nonetheless, histatins ... Shimada T (June 2006). "Salivary proteins as a defense against dietary tannins". Journal of Chemical Ecology. 32 (6): 1149-63. ...

https://en.wikipedia.org/wiki/Histatin

name="Cambridge 2017, p1-278." name="Cambridge 2017, p369-371." Strömgren E (1986) Reactive (psychogenic) psychoses and their ... Aberrant steroid hormone-dependent regulation of neuronal calcium influx via extracellular matrix proteins and membrane ...

https://en.wikipedia.org/wiki/Postpartum_psychosis

These include nitrosamines, reactive aldehydes, and polycylic hydrocarbons, including benz[a]pyrene. Marijuana smoke was listed ... changed blood proteins associated with heart disease and stroke. A 2000 study by researchers at Boston's Beth Israel Deaconess ... and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons". The Journal of ...

https://en.wikipedia.org/wiki/Effects_of_cannabis

It is one of a group of proteins, called acute phase reactants, that go up in response ... C-reactive protein (CRP) is produced by the liver. The level of CRP rises when there is inflammation throughout the body. ... C-reactive protein (CRP) is produced by the liver. The level of CRP rises when there is inflammation throughout the body. It is ... A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a persons ...

https://medlineplus.gov/ency/article/003356.htm

C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia? ... C-reactive protein concentrations as a marker of inflammation or infection for interpreting biomarkers of micronutrient status ... The study aimed to determine whether serum C-reactive protein [‎CRP]‎ levels can be used to identify when antibiotics can ...

https://apps.who.int/iris/browse?authority=C-Reactive+Protein&type=mesh

... Arch Dis Child. 2008 Aug;93(8):676-80. doi: 10.1136/adc.2006.109371. Epub 2007 ... Objective: To assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C-reactive protein ( ...

https://pubmed.ncbi.nlm.nih.gov/17641003/

C-Reactive Protein. C-reactive protein (CRP) is an acute-phase reactant synthesized by the liver in response to infection or ... Leukocyte count, C reactive protein, alpha-1 acid glycoprotein and erythrocyte sedimentation rate in acute appendicitis]. Arq ... Asfar S, Safar H, Khoursheed M, Dashti H, al-Bader A. Would measurement of C-reactive protein reduce the rate of negative ... Diagnostic value of C-reactive protein in acute appendicitis. Dis Colon Rectum. 1994 Jan. 37(1):49-51. [QxMD MEDLINE Link]. ...

https://www.medscape.com/answers/773895-14482/can-ultrasonography-be-used-to-diagnose-appendicitis-in-women-of-childbearing-age

The reference range for C-reactive protein is as follows: CRP: 0-10mg/dL High-sensitivity CRP (hs-CRP): < 3 mg/L ... encoded search term (C-Reactive Protein) and C-Reactive Protein What to Read Next on Medscape ... C-Reactive Protein Updated: May 03, 2022 * Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP, FAMIA; Chief ... C-reactive protein and coronary heart disease: a critical review. J Intern Med. 2008 Oct. 264(4):295-314. [QxMD MEDLINE Link]. ...

https://emedicine.medscape.com/article/2086909

C-reactive protein (CRP) is a commonly used marker of inflammation, and inflammatory disease is suspected when CRP levels ... CHICAGO - Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk ... Elevated levels of C-reactive protein appear associated with psychological distress, depression Peer-Reviewed Publication JAMA ... Elevated levels of C-reactive protein appear associated with psychological distress, depression. JAMA Network ...

https://www.eurekalert.org/news-releases/761563

C-reactive protein(mg/dL). Variable Name: LBXCRP. SAS Label: C-reactive protein(mg/dL). English Text: C-reactive protein (mg/dL ... C-Reactive Protein (CRP) (CRP_E) Data File: CRP_E.xpt First Published: September 2009. Last Revised: NA ... C-reactive protein is considered one of the best measures of the acute-phase response to an infectious disease or other cause ...

https://wwwn.cdc.gov/Nchs/Nhanes/2007-2008/CRP_E.htm

https://extranet.who.int/iris/restricted/browse?locale-attribute=en&type=mesh&authority=C-Reactive+Protein

C-Reactive Protein (Blood). Does this test have other names?. CRP. What is this test?. The C-reactive protein (CRP) test is ... CRP is a protein made by the liver and sent into the bloodstream. Blood levels may be higher when you have inflammation or an ...

https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=c_reactive_protein_serum

C-reactive protein (CRP) is the dominant acute phase protein in mammals 1. Elevated levels of CRP are not disease specific but ... C-reactive protein (CRP) is an acute phase protein produced by the liver in response to inflammation, infection and tissue ... Tags: C-Reactive Protein, Cardiovascular Disease, inflammatory biomarker, CVD, COVID-19, Cerebrovascular accident, CVA, AD, ... Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for ...

https://www.randox.com/tag/c-reactive-protein/

The LUCAS mortality score included five strongest predictors (Lymphocyte count, Urea, C-reactive protein, Age, Sex), which are ... Tan, C. et al. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early. J. Med. ... All NCCID patients tested positive by the RT-PCR test for SARS-CoV-2. WCC, white blood count; CRP, C-reactive protein. The p- ... A robust COVID-19 mortality prediction calculator based on Lymphocyte count, Urea, C-Reactive Protein, Age and Sex (LUCAS) with ...

https://www.nature.com/articles/s41598-022-21803-2?error=cookies_not_supported&code=bf526fe0-2070-4c2f-a8fb-da18de4a2383

Effect of C-reactive protein on Fcgamma receptor II in cultured bovine endothelial cells. Escribano-Burgos, M., López-Farré, A ... A new purification procedure for bovine C-reactive protein and serum amyloid P component. Sarikaputi, M., Morimatsu, M., Syuto ... Western blot experiments showed that TNF-alpha decreased the expression of the eNOS protein, which was partially protected by ... 1. A new purification procedure was started with salting-out fractionation of serum proteins at 45-75% saturated ammonium ...

https://www.wikigenes.org/e/gene/e/445432.html

Background: C-reactive protein level (CRP) and white blood cell count (WBC) have been variably used in clinical trials on acute ... Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies ... Main Outcome Measures: Parameters of chronic inflammation (high-sensitivity C-reactive protein [hs-CRP], and pentraxin 3 [PTX-3 ... Our findings suggest the C-reactive protein depression association is symptom-specific and modified by antidepressant treatment ...

https://helda.helsinki.fi/browse?value=C-REACTIVE%20PROTEIN&type=subject

Page navigation anchor for Value of C-reactive protein in elderly and immunocompromised patients unclear. Value of C-reactive ... C-reactive protein testing leads to a reduction in antibiotic use in patients with respiratory tract infections Lars Bjerrum ... Value of C-reactive protein in elderly and immunocompromised patients unclear Wim Opstelten ... Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest. 2004; ...

https://www.annfammed.org/content/8/2/124/tab-e-letters

C-Reactive Protein) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-05438. USA, UK & Europe Distribution. ... Rat hs-CRP (high-sensitivity C-Reactive Protein) ELISA Kit , G-EC-05993 ... Rat CRP (C-Reactive Protein) ELISA Kit , G-EC-05438. Rating * Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 ... Rat CRP (C-Reactive Protein) ELISA Kit DataSheet. Citation #1. Citation #2. Citation #3. Citation #4. Citation #5 ...

https://caslab.com/rat-crp-c-reactive-protein-elisa-kit-g-ec-05438/

C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia? ... Sepsis and C-reactive protein. Pediatrics, 1994, 93:693-4.. *Kawamura M, Nishida H. The usefulness of serial C-reactive protein ... C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia? ... C-reactive protein (CRP), an acute-phase reactant, is synthesized in the liver in response to inflammatory cytokines and may ...

http://www.emro.who.int/emhj-volume-15-2009/volume-15-issue-2/article3.html

C- reactive protein in schizophrenia-spectrum disorders; relationship to cognitive functions and medications. Fathian, Farivar ... Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis, Acta ... Associations between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute ... The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis, BMC psychiatry. ...

https://bora.uib.no/bora-xmlui/handle/1956/21451

... is an acute phase reactant protein synthesized in the liver. Human body proportions, such as body mass index (BMI), may affect ... C-reactive protein (CRP) is an acute phase reactant protein synthesized in the liver. Human body proportions, such as body mass ... C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. Diabetologia 2004;47:1403- ... C-Reactive Protein Levels do Not Correlate with Body Mass Index in Patients Hospitalized with Infectious Diseases: A ...

https://www.researchsquare.com/article/rs-1034053/v1

Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of ... From: C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis ...

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02506-x/tables/2

C-reactive protein, Diseases and disorders of/related to bone, Epidemiology, Fracture risk assessment, General population ... Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study ... Summary: Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between ... Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study ...

https://repub.eur.nl/pub/65832

C-reactive protein (CRP) and endoscopic lesions are objective measures of inflammation. We investigated the relationships ... Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohns disease in the SONIC trial Laurent ... C-reactive protein (CRP) and endoscopic lesions are objective measures of inflammation. We investigated the relationships ... C-reactive protein normalisation and mucosal healing in Crohns disease in the SONIC trial. Gut, 2013, 63 (1), pp.88 - 95. ⟨ ...

https://hal.univ-lorraine.fr/hal-01687425

A high-risk profile of elevated cell-free DNA, carcinoembryonic antigen, and C-reactive protein was described, but in combined ... A high-risk profile of elevated cell-free DNA, carcinoembryonic antigen, and C-reactive protein was described, but in combined ... A high-risk profile of elevated cell-free DNA, carcinoembryonic antigen, and C-reactive protein was described, but in combined ... A high-risk profile of elevated cell-free DNA, carcinoembryonic antigen, and C-reactive protein was described, but in combined ...

https://forskning.ruc.dk/da/publications/total-cell-free-dna-carcinoembryonic-antigen-and-c-reactive-prote

Anti-SLIP1-reactive proteins exist on human spermatozoa and are involved in zona pellucida binding Academic Article ...

https://experts.mcmaster.ca/display/publication1648157

To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis ... From: Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled ...

https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-017-0207-6/tables/1

Implications of fever on erythrocyte sedimentation rate but not on C-reactive protein concentrations at the time of diagnosis ...

https://www.clinexprheumatol.org/abstract.asp?a=17886

Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry ... 2011) Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass ... Tumor suppressor proteins, p53 protein, Fourier transform spectroscopy, Mass spectroscopy, Fragmentation reactions, Cysteine ... The assignment of Cys182 and Cys277 as the two reactive Cys residues was confirmed by site-directed mutagenesis. Further ...

http://wrap.warwick.ac.uk/40308/

C-reactive protein and hemogram parameters for the nonsepsis SIRS and sepsis: what do they mean?. Access & Citations. * 690 ...

https://ccforum.biomedcentral.com/articles/10.1186/cc14131/metrics

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(ii)-NTA probe. / Uchinomiya, Sho Hei; Nonaka, ... A new method for covalent labeling of a His-tag fused protein with a small reactive probe was developed; this method is based ... N2 - A new method for covalent labeling of a His-tag fused protein with a small reactive probe was developed; this method is ... AB - A new method for covalent labeling of a His-tag fused protein with a small reactive probe was developed; this method is ...

https://kyushu-u.pure.elsevier.com/en/publications/site-specific-covalent-labeling-of-his-tag-fused-proteins-with-a-

Government-backed funding and a surge in infectious diseases are expected to drive the market demand for the c-reactive protein ... C-reactive protein (CRP) tests are blood tests that are performed to measure C-reactive protein levels. C-reactive protein (CRP ... Key Trends Observed in the C-reactive Protein Testing Market The C-reactive protein testing market is being boosted by ... of innovative techniques for measuring C-reactive protein concentrations opens up new opportunities for the C-reactive protein ...

https://www.polarismarketresearch.com/blog/c-reactive-protein-testing-market-share-size-trends-outlook

Leu310 of mouse HS1 protein, Ala1153 of mouse CD11c protein, and Glu179 of mouse cathepsin D protein. Antibodies are also ... Mouse Reactive Alzheimers Disease Model Microglia Phenotyping IF Antibody Sampler Kit Mouse Reactive Alzheimers Disease Model ... Pathways & Proteins. Explore pathways + proteins related to this product.. Select Your Pathway/Protein. Alzheimers Disease. ... Transmembrane protein 119 (TMEM119) is a cell-surface protein of unknown function, expressed exclusively by the microglia ...

https://www.cellsignal.com/products/primary-antibodies/mouse-reactive-alzheimer-s-disease-model-microglia-phenotyping-if-antibody-sampler-kit/30182

It is one of a group of proteins, called acute phase reactants, that go up in response to inflammation. (medlineplus.gov)
These proteins are produced by white blood cells during inflammation. (medlineplus.gov)
C-reactive protein (CRP) is an acute-phase reactant synthesized by the liver in response to infection or inflammation and rapidly increases within the first 12 hours. (medscape.com)
C-reactive protein is considered one of the best measures of the acute-phase response to an infectious disease or other cause of tissue damage and inflammation. (cdc.gov)
C-reactive protein (CRP) is a commonly used marker of inflammation, and inflammatory disease is suspected when CRP levels exceed 10 mg/L. Researchers are unclear whether and to what extent elevated CRP levels are associated with psychological distress and depression in the general population, according to the study background. (eurekalert.org)
The C-reactive protein (CRP) test is used to find inflammation in your body. (rochester.edu)
CRP is an acute-phase protein produced by the liver during conditions of inflammation, bacterial infection, or tissue trauma. (bdbiosciences.com)
The findings show that higher levels of C-reactive protein in young adults are associated with subsequent decline in lung function, suggesting that low-grade systemic inflammation in young adulthood may lead to impaired lung function independently of the effects of smoking, obesity, cardiorespiratory fitness, asthma and eosinophilic inflammation. (ersjournals.com)
Blood C-reactive protein (CRP), a marker of systemic inflammation, has consistently been found to be associated with excess mortality and adverse cardiovascular outcomes independently of confounding factors such as age and smoking 1 . (ersjournals.com)
It was hypothesised that high levels of CRP would be associated with the subsequent decline in lung function after adjusting for the potential confounding influences of body mass index (BMI), cardiorespiratory fitness, smoking, asthma, AHR and serum eosinophil cationic protein (ECP) as a marker of eosinophilic inflammation. (ersjournals.com)
Emerging evidence indicates involvement of immune system and inflammation in the pathophysiology of schizophrenia, and elevation of the inflammatory marker C-reactive protein (CRP) has been observed with association to pathogenesis and symptomatology including cognitive dysfunctions. (uib.no)
C-reactive protein (CRP) and endoscopic lesions are objective measures of inflammation. (univ-lorraine.fr)
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. (lifespan.io)
Infections and disorders that cause inflammation, such as cancers, cardiovascular diseases, arthritis, and others, are detected and tracked using C-reactive tests. (polarismarketresearch.com)
For instance, BlueCross BlueShield of North Carolina covers reimbursement for general inflammation testing and provides C-reactive protein testing for the diagnosis of inflammatory diseases. (polarismarketresearch.com)
The level of C-reactive protein (CRP), which can be measured in your blood, increases when there's inflammation in your body. (norvichospital.com)
A blood test for the presence of C-reactive protein indicates inflammation or infection. (letscheckup.in)
Inflammation indicator commonly used is C-reactive protein (CRP). (ugm.ac.id)
C-Reactive protein is a class of proteins produced in hepatocytes during inflammation with good sensitivity. (ugm.ac.id)
Role of C-Reactive Protein in Diabetic Inflammation. (bvsalud.org)
They also revealed that IL-6 not only enhances antibody production but also has a wide range of functions, including its role as a key stimulus for hepatic production of C-reactive protein* 3 (CRP) during the acute phase of inflammation and as a growth factor for multiple myeloma. (japanprize.jp)
3 CRP is a protein found in the blood in response to inflammation or tissue destruction. (japanprize.jp)
A plasma protein that circulates in increased amounts during inflammation and after tissue damage. (bvsalud.org)

The study aimed to determine whether serum C-reactive protein [‎CRP]‎ levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. (who.int)
and management and investigations postvaccination, including serum C reactive protein levels, infection screens and antibiotic use. (bmj.com)

The levels of acute phase reactants increase in response to certain inflammatory proteins called cytokines. (medlineplus.gov)
To assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C-reactive protein (hsCRP) levels. (nih.gov)
CHICAGO - Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk of psychological distress and depression in the general population of adults in Denmark, according to a report published Online First by Archives of General Psychiatry , a JAMA Network publication. (eurekalert.org)
In this study, we investigated the association of preoperative C-reactive protein levels with the development of de novo Crohn's disease after ileal pouch-anal anastomosis. (lww.com)
Preoperative C-reactive protein levels were compared between patients who developed de novo Crohn's disease and those who did not. (lww.com)
In hospitalized patients undergoing ileal pouch-anal anastomosis for medically refractory ulcerative colitis , higher preoperative C-reactive protein levels appear to increase the risk of developing de novo Crohn's disease. (lww.com)
Because the amount of CRP associated with cardiovascular disease is much lower than the amount associated with inflammatory diseases, the high-sensitivity C-reactive protein test (hs-CRP) is used since it can detect much lower levels than the standard CRP test. (groupeproxim.ca)
In a multiple regression analysis adjusted for sex, body mass index, cardiorespiratory fitness, smoking, asthma, airway hyperresponsiveness and serum eosinophil cationic protein, higher levels of CRP at age 20 yrs were associated with a greater reduction in both FEV 1 and forced vital capacity between ages 20 and 29 yrs. (ersjournals.com)
Paper II: Farivar Fathian, Else-Marie Løberg, Rolf Gjestad, Vidar M. Steen, Rune A. Kroken, Hugo A. Jørgensen, Erik Johnsen: Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis, Acta Neuropsychiatrica. (uib.no)
Associations between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis. (uib.no)
The aim was to analyze the prognostic value of plasma levels of total cell-free DNA, carcinoembryonic antigen and C-reactive protein in 97 heavily pretreated patients with metastatic colorectal cancer. (ruc.dk)
Serum carcinoembryonic antigen and C-reactive protein had similar prognostic value with short overall survival and progression-free survival in patients with elevated levels compared to those within normal range. (ruc.dk)
We tested the effects of APOE variants on triglyceride levels and their interactions with the inflammatory marker C-reactive protein (CRP) in a Taiwanese population. (biomedcentral.com)
C-reactive protein (CRP) tests are blood tests that are performed to measure C-reactive protein levels. (polarismarketresearch.com)
C-reactive protein (CRP) is a protein released by the liver, and its levels rise when the body is inflamed. (polarismarketresearch.com)
Some researchers think that treating people with high C-reactive protein levels will lessen their risk of heart attack or stroke. (norvichospital.com)
A new study published in the latest issue of the medical journal Lancet shows that a CT Heart Scan is a better predictor of heart attack risk than cholesterol levels or C-Reactive Protein. (princetonlongevitynews.com)
Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor α (TNF-α) and interleukin 6 ( IL-6 ), which are pivotal factors for CRP stimulation. (bvsalud.org)
Our results showed that all dosages induced no significant alterations in growth parameters and the seric levels of total protein, albumin, globulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides and activities of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, alkaline phosphatase and lactate dehydrogenase, when compared to the control group. (blogspot.com)
To test for it, doctors use indirect methods by measuring blood levels of C-reactive protein, a pro-inflammatory marker, and homocysteine levels. (naturalsociety.com)
2007). Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats . (up.pt)
This leads to a dysregulation of triglyceride and free fatty acid levels, as well as a dysregulation of specific adipocyte-derived secretory proteins, a group of proteins that we refer to as adipokines. (diabetesjournals.org)
The GWAS approach also demonstrated associations of common variants in HNF1A with levels of C-reactive protein, which is a potential biomarker of the condition. (cdc.gov)
Our results have been absolutely encouraging: people having moderate amounts of dark chocolate regularly have significantly lower levels of C-reactive protein in their blood. (glutenfreeforgood.com)
Elevated Blood Pressure, Race/Ethnicity, and C-Reactive Protein Levels in Children and Adolescents. (bvsalud.org)
Regarding biomarkers, 80% had elevated LDH levels, 34% elevated D-dimer levels, 100% elevated C-reactive protein, 43.7% elevated procalcitonin, and 89.3% elevated ferritin. (bvsalud.org)
Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation. (cdc.gov)

Associations between high-sensitive C-reactive protein (CRP) and spirometric lung function were assessed in a population-based cohort of ∼1,000 Danes aged 20 yrs. (ersjournals.com)
to assess level of serum and ascetic fluid polymorph nuclear leucocytes (PMN), high sensitive C reactive protein ( hs-CRP ) in patients with SBP before and after treatment . (bvsalud.org)

C-reactive protein, pentraxin-related. (medscape.com)

Implications of fever on erythrocyte sedimentation rate but not on C-reactive protein concentrations at the time of diagnosis of polymyalgia rheumatica. (clinexprheumatol.org)
Furthermore, the advancement of innovative techniques for measuring C-reactive protein concentrations opens up new opportunities for the C-reactive protein research industry to expand. (polarismarketresearch.com)

Haemoglobin, platelets, albumin and C-reactive protein were not predictive of preterm delivery or stillbirth. (bmj.com)
Liver function enzymes, aspartate aminotransferase, and alanine aminotransferase activities including total cholesterol, total protein, albumin, and globulin were not changed by BV supplementation. (blogspot.com)

Novel biomarkers of risk, such as apolipoprotein (Apo) A1 and ApoB (2), and the inflammatory markers C-reactive protein (CRP), fibrinogen, and homocysteine (3-5), have been proposed. (cdc.gov)

Vesicants are highly reactive chemicals that combine with proteins, DNA, and other cellular components to result in cellular changes immediately after exposure. (cdc.gov)

C-reactive protein (CRP) is the dominant acute phase protein in mammals 1 . (randox.com)
CRP is an acute phase protein, synthesized by hepatocytes, in response to IL-6 and IL-1β signalling (1). (researchsquare.com)

Erythrocyte sedimentation rate and C-reactive protein were not elevated. (hindawi.com)
Erythrocyte sedimentation rate and C reactive protein were elevated, and blood cultures grew methicillin-resistant Staphylococcus aureus (MRSA). (bmj.com)
The patient was having routine screening laboratory evaluations for his age completed that day, so the physician also ordered an erythrocyte sedimentation rate and C-reactive protein which were normal. (pediatriceducation.org)

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. (duke.edu)
0.001 ), which was absent in the presence of a quencher of reactive oxygen species (ROS). (duke.edu)
RAW264.7 cells exposed to MMA-SS had elevated generation of reactive oxygen species (ROS), protein-HNE (P-HNE) adduct formation, activation of ERK1/2, and expression of cyclooxygenase-2 (COX-2) compared to GMA-MS and control. (cdc.gov)
One of the major sources of reactive oxygen species (ROS) in neurodegeneration is NADPH oxidase, a multimeric enzyme that generates both superoxide O 2 − (O 2 and H 2 O 2 [ 8 ]. (springer.com)

A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a person's risk for heart disease. (medlineplus.gov)
A similar version of the test, known as hs-CRP (high-sensitivity C-reactive protein), is specifically used to determine a person's risk for cardiovascular disease. (groupeproxim.ca)

In the morning of the second day after apheresis, the platelet count dropped, procalcitonine level was elevated, C-reactive protein level was elevated, and a slight skin rash developed. (cdc.gov)

As for instance, in a patient with a monoclonal protein without any evidence of infection, ESR may be high (in 100) but CRP will be normal. (medscape.com)
Alternatively, cross-reactive antibodies that are generated following vaccination or infection, might become damaging during subsequent infections. (ox.ac.uk)
A serum sample test showed a weak positive result for dengue virus by using IgM and IgG antibody tests, and a strong positive result for dengue virus nonstructural protein-1, or NS1, antigen, demonstrating acute dengue virus infection. (cdc.gov)

C polymorphism and C-reactive protein in idiopathic cardiac arrhythmias in children. (cdc.gov)

Summary: Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. (eur.nl)
C-reactive protein is useful in identifying bacterial and non-bacterial infections in ongoing studies in Southeast Asian countries, and it can be used as a biomarker to guide antibiotic prescriptions. (polarismarketresearch.com)

The Canine C-Reactive Protein (CRP) ELISA Kit is designed for the detection and quantitation of canine CRP in canine serum. (bdbiosciences.com)

Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study. (hopkinsmedicine.org)
Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? (insa-lyon.fr)
A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. (norvichospital.com)
C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). (bvsalud.org)

C-reactive protein (CRP) is produced by the liver. (medlineplus.gov)
[ 4 ] It is a member of pentraxin family of proteins and is synthesized by liver. (medscape.com)
CRP is a protein made by the liver and sent into the bloodstream. (rochester.edu)
C-reactive protein (CRP) is an acute phase reactant protein synthesized in the liver. (researchsquare.com)
Apical periodontitis is a bacteria-induced disease that activates the localized release of pro-inflammatory mediators capable of inducing the production of acute-phase proteins (like C-reactive protein) by the liver. (bvsalud.org)

Cross-reactive dengue virus-derived monoclonal antibodies to Zika virus envelope protein: Panacea or Pandora's box? (ox.ac.uk)
Preparation of monoclonal antibodies reactive with beta-1,2-linked oligomannosyl residues in the phosphomannan-protein complex of Candida albicans NIH B-792 strain. (utmb.edu)

Other sugars and polyols have been explored as a partner chemical that provides many hydrogen bonding sites that stabilize the complex 3-D structure of proteins, enzymes, and nucleic acids in the absence of water but trehalose seems to be one of the best. (grisda.org)
It is believed that tardigrades produce various "dry-tolerant proteins" that "are intrinsically disordered in water but develop secondary structures in the dehydrated state that allow them to stabilize DNA, proteins, and cell membranes. (grisda.org)

Around the same time, we and others described a protein that we initially termed Acrp30, which later became known as adiponectin ( 7 - 10 ). (diabetesjournals.org)

Background: Several studies have revealed inverse associations between physical activity (PA) and C-reactive protein (CRP). (unf.edu)

Amino acids, peptides, and proteins. (medlineplus.gov)

The formation of intracellular amyloid-like inclusions by mutant proteins is a feature of two groups of codon reiteration diseases, for which there are currently no treatments. (bmj.com)
In mammalian cell based models of both polyglutamine and polyalanine diseases, the mutant proteins are much more prone to aggregate formation than their wild-type counterparts and cause significantly more cell death. (bmj.com)
Our previous studies suggested that mammalian heat shock proteins might be able to play similar roles in both diseases. (bmj.com)

The results provide evidence for considerable biotransformation and protein adduct formation when cytochrome P450 activity is induced in the cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin, a model Ah receptor ligand. (cdc.gov)

This study highlights the power of top-down FTICR mass spectrometry for analysis of the cysteine reactivity and redox chemistry in multiple cysteine-containing proteins. (warwick.ac.uk)

For instance, in November 2019, researchers developed an impermanent smartphone-based diffusometric immunoassay for determining the C-reactive protein test. (polarismarketresearch.com)

C-reactive protein (CRP) has been indicated to be associated with the pathogenesis of schizophrenia (SZ) and other psychiatric disorders. (oncotarget.com)

The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a protein homologous to the brown fat uncoupling protein Ucp1 (refs 1-3). (duke.edu)
A functional variant in the promoter region regulates the C-reactive protein gene and is a potential candidate for increased risk of atrial fibrillation. (cdc.gov)
C-reactive protein gene polymorphism predicts the risk of thromboembolic stroke in patients with atrial fibrillation: a more than 10-year prospective follow-up study. (cdc.gov)

Gestational diabetes, maternal serum cholesterol, and C-reactive protein were unrelated to children's BMI trajectories. (rti.org)

Background: C-reactive protein level (CRP) and white blood cell count (WBC) have been variably used in clinical trials on acute pancreatitis (AP). (helsinki.fi)
A simple blood test measures C-reactive protein. (norvichospital.com)
A Crp test is a blood test that is used to look for a protein called C-reactive protein (CRP). (letscheckup.in)
No significant difference between the groups was seen for urine red blood cell (RBC) count, protein, or specific gravity. (lww.com)
Urinalysis is negative for blood, protein, and white blood cells. (medscape.com)

C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia? (who.int)

Bilirubin is a metabolite of haem, derived from haem-containing proteins, including myoglobin, haemoglobin and various P450 enzymes, that serves to coordinate iron in various proteins. (randox.com)
Trehalose can help enzymes and proteins preserve their activity when lyophilized (freeze-dried) together. (grisda.org)

Having C-reactive protein in the third tertile significantly increased the risk of developing de novo Crohn's disease (HR 3.44, 95% CI 1.10- 10.70, p = 0.03) compared to in the first tertile. (lww.com)
In a multivariable model, a C-reactive protein in the third or second tertile vs the first tertile and younger age was associated with the development of de novo Crohn's disease. (lww.com)

In conclusion, total cell-free DNA in plasma, carcinoembryonic antigen, and C-reactive protein could all contribute to assessment of patients' prognosis and potentially aid in clinical decision making in patients with metastatic colorectal cancer. (ruc.dk)

To minimize the heterogeneity of the timing of preoperative C-reactive protein measurement and the severity of ulcerative colitis , only hospitalized patients who had proctocolectomy for severe ulcerative colitis were included in the study. (lww.com)

By eliminating the neurostimulants in our diet (such as MSG, aspartame and the food naturally rich in their parent proteins, glutamate and aspartate), miracles can occur…and quickly, too. (dogtorj.com)

Background - C-reactive protein (CRP), an acute-phase reactant long considered merely an innocent bystander in the inflammatory process, is now recognized as a powerful predictor of cardiovascular events. (uab.edu)

Thus, disease is associated with expansions of 12 or more uninterrupted alanines in this nuclear protein. (bmj.com)

Paper I: Erik Johnsen1, Farivar Fathian1, Rune A. Kroken, Vidar M. Steen, Hugo A. Jørgensen, Rolf Gjestad, Else-Marie Løberg: The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis, BMC psychiatry. (uib.no)
Your doctor may check your C-reactive protein level treatment for infections or for other medical conditions. (norvichospital.com)

The assignment of Cys182 and Cys277 as the two reactive Cys residues was confirmed by site-directed mutagenesis. (warwick.ac.uk)
Further alkylation of p53 beyond Cys182 and Cys277 was found to trigger co-operative modification of the remaining seven Cys residues and protein unfolding. (warwick.ac.uk)
Hybridomas obtained by fusing the spleen cells of BALB/c female mice hyperimmunized with heat-killed yeast-form cells of Candida albicans NIH B-792 strain and a mouse myeloma cell line, P3X63Ag8.653, produced antibodies to beta-1,2-linked oligomannosyl residues in the phosphomannan-protein complex of the parent cells. (utmb.edu)

While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors to communicate with essentially every organ system in the body. (diabetesjournals.org)

Inflammatory markers like C-reactive protein (CRP) have been associated with post-traumatic stress disorder (PTSD) and traumatic experiences, but the underlying mechanisms are unclear. (nature.com)
Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), gp91phox and inducible nitric oxide synthase (iNOS), were measured in the nigrostriatal system. (springer.com)

Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population. (cdc.gov)

Magnitude of Preoperative C-Reactive Protein Elevation Is As. (lww.com)

Serum carcinoembryonic antigen and C-reactive protein were analyzed by routine methods. (ruc.dk)
A high-risk profile of elevated cell-free DNA, carcinoembryonic antigen, and C-reactive protein was described, but in combined Cox regression multivariate analysis, only total cell-free DNA preserved a strong prognostic value. (ruc.dk)

Anatomy1

Diseases23

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes6

Named Groups1

Health Care18

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/7727)

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (2/7727)

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. (3/7727)

Socioeconomic status and determinants of hemostatic function in healthy women. (4/7727)

Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study. (5/7727)

Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. (6/7727)

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (7/7727)

Leptin elimination in hyperleptinaemic peritoneal dialysis patients. (8/7727)

C-Reactive Protein

Blood Sedimentation

Biological Markers

Arthritis, Rheumatoid

Acute-Phase Reaction

Serum Amyloid A Protein

Tuberculosis, Miliary

Spondylitis, Ankylosing

Antirheumatic Agents

Nephelometry and Turbidimetry

Gold Sodium Thiomalate

Polyarteritis Nodosa

Leukocyte Count

Mendelian Randomization Analysis

Bacterial Infections

Rheumatoid Factor

Orosomucoid

Polymyalgia Rheumatica

Prospective Studies

Arthritis, Psoriatic

Acute Disease

Complement C4

Meningitis, Viral

Statistics, Nonparametric

Synovitis

Calcitonin

Severity of Illness Index

Latex Fixation Tests

Fever

Crohn Disease

Infant, Premature, Diseases

Synovial Fluid

Osteoarthritis

Acute-Phase Proteins

Arthritis

Sepsis

Interleukin-6

Infant, Newborn

Pancreatitis

Case-Control Studies

Enzyme-Linked Immunosorbent Assay

Angina, Unstable

Risk Factors

Prednisolone

Treatment Outcome

Prognosis

Cross-Sectional Studies

Time Factors

Double-Blind Method

Inflammation

False Positive Reactions

Follow-Up Studies

Inflammation Mediators

Anti-Inflammatory Agents

Cardiovascular Diseases

Predictive Value of Tests

Immunoglobulin G

Tumor Necrosis Factor-alpha

Chi-Square Distribution

Antibodies, Monoclonal

Coronary Disease

Glucocorticoids

Analysis of Variance

Autoantibodies

ROC Curve

Lipids

Body Mass Index

Drug Therapy, Combination

Pilot Projects

Sensitivity and Specificity

Cohort Studies

Troponin T

Disease Progression

Molecular Weight

Retrospective Studies

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/7727)

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (2/7727)

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. (3/7727)

Socioeconomic status and determinants of hemostatic function in healthy women. (4/7727)

Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study. (5/7727)