C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Plasticizers: Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.Protein Array Analysis: Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Heart: The hollow, muscular organ that maintains the circulation of the blood.TriglyceridesJournal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Occult Blood: Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.FluorobenzenesProspective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Proton-Phosphate Symporters: Proteins that cotransport hydrogen ions and phosphate ions across cellular membranes.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Acute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Acute-Phase Reaction: An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.Serum Amyloid A Protein: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Inflammation Mediators: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).CitrullineArthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Logical Observation Identifiers Names and Codes: A vocabulary database of universal identifiers for laboratory and clinical test results. Its purpose is to facilitate the exchange and pooling of results for clinical care, outcomes management, and research. It is produced by the Regenstrief Institute. (LOINC and RELMA [Internet]. Indianapolis: The Regenstrief Institute; c1995-2001 [cited 2002 Apr 2]. Available from http://www.regenstrief.org/loinc)Clinical Laboratory Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Hospitals, Pediatric: Special hospitals which provide care for ill children.History, 19th Century: Time period from 1801 through 1900 of the common era.History, 20th Century: Time period from 1901 through 2000 of the common era.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Patient Satisfaction: The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/7727)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability. (2/7727)

BACKGROUND: In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability. METHODS AND RESULTS: We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (>3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP <3 mg/L but 69% of those with elevated CRP (P<0.001) were readmitted because of recurrence of instability or new myocardial infarction. New phases of instability occurred in 13% of patients in the lower tertile of CRP (/=8.7 mg/L, P<0.001). The prognostic value of SAA was similar to that of CRP; that of fibrinogen was not significant. Chlamydia pneumoniae but not Helicobacter pylori antibody titers significantly correlated with CRP plasma levels. CONCLUSIONS: In unstable angina, CRP may remain elevated for at >/=3 months after the waning of symptoms and is associated with recurrent instability. Elevation of acute-phase reactants in unstable angina could represent a hallmark of subclinical persistent instability or of susceptibility to recurrent instability and, at least in some patients, could be related to chronic Chlamydia pneumoniae infection.  (+info)

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency. (3/7727)

Criteria of the systemic inflammatory response syndrome (SIRS) are known to include patients without systemic inflammation. Our aim was to explore additional markers of inflammation that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1beta, tumour necrosis factor-alpha and C-reactive protein were determined, and severity of inflammation was evaluated by systemic inflammation composite score based on CD11b expression, C-reactive protein and cytokine levels. Levels of CD11b expression, C-reactive protein and interleukin-6 were higher in sepsis patients than in SIRS patients who met two criteria (SIRS2 group) or three criteria of SIRS (SIRS3 group). The systemic inflammation composite score of SIRS2 patients (median 1.5; range 0-8, n=56) was lower than that of SIRS3 patients (3.5; range 0-9, n=14, P=0.013) and that of sepsis patients (5.0; range 3-10, n=19, P<0.001). The systemic inflammation composite score was 0 in 13/94 patients. In 81 patients in whom systemic inflammation composite scores exceeded 1, interleukin-6 was increased in 64 (79.0%), C-reactive protein in 59 (72.8%) and CD11b in 50 (61.7%). None of these markers, when used alone, identified all patients but at least one marker was positive in each patient. Quantifying phagocyte CD11b expression and serum interleukin-6 and C-reactive protein concurrently provides a means to discriminate SIRS patients with systemic inflammation from patients without systemic inflammation.  (+info)

Socioeconomic status and determinants of hemostatic function in healthy women. (4/7727)

Hemostatic factors are reported to be associated with coronary heart disease (CHD). Socioeconomic status (SES) is 1 of the determinants of the hemostatic profile, but the factors underlying this association are not well known. Our aim was to examine determinants of the socioeconomic differences in hemostatic profile. Between 1991 and 1994, we studied 300 healthy women, aged 30 to 65 years, who were representative of women living in the greater Stockholm area. Fibrinogen, factor VII mass concentration (FVII:Ag), activated factor VII (FVIIa), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1) were measured. Educational attainment was used as a measure of SES. Low educational level and an unfavorable hemostatic profile were both associated with older age, unhealthful life style, psychosocial stress, atherogenic biochemical factors, and hypertension. Levels of hemostatic factors increased with lower educational attainment. Independently of age, the differences between the lowest (mandatory) and highest (college/university) education in FVII:Ag levels were 41 microg/L (95% confidence interval [CI], 15 to 66 microg/L, P=0.001), 0.26 g/L (95% CI, 0.10 to 0.42 g/L, P=0.001) in fibrinogen levels, and 0.11 U/mL (95% CI, 0.09 to 0.12 U/mL, P=0.03) in levels of vWF. The corresponding differences in FVIIa and PAI-1 were not statistically significant. With further adjustment for menopausal status, family history of CHD, marital status, psychosocial stress, lifestyle patterns, biochemical factors, and hypertension, statistically significant differences between mandatory and college/university education were observed in FVII:Ag (difference=34 microg/L; 95% CI, 2 to 65 microg/L, P=0.05) but not in fibrinogen (difference=0.03 g/L; 95% CI, -0.13 to 0.19 g/L, P=0.92) or in vWF (difference=0.06 U/mL; 95% CI, -0.10 to 0.22 U/mL, P=0.45). An educational gradient was most consistent and statistically significant for FVII:Ag, fibrinogen, and vWF. Age, psychosocial stress, unhealthful life style, atherogenic biochemical factors, and hypertension mediated the association of low educational level with elevated levels of fibrinogen and vWF. Psychosocial stress and unhealthful life style were the most important contributing factors. There was an independent association between education and FVII:Ag, which could not be explained by any of these factors.  (+info)

Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study. (5/7727)

BACKGROUND: Chlamydia pneumoniae commonly causes respiratory infection, is vasotropic, causes atherosclerosis in animal models, and has been found in human atheromas. Whether it plays a causal role in clinical coronary artery disease (CAD) and is amenable to antibiotic therapy is uncertain. METHODS AND RESULTS: CAD patients (n=302) who had a seropositive reaction to C pneumoniae (IgG titers >/=1:16) were randomized to receive placebo or azithromycin, 500 mg/d for 3 days, then 500 mg/wk for 3 months. Circulating markers of inflammation (C-reactive protein [CRP], interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha), C pneumoniae antibody titers, and cardiovascular events were assessed at 3 and 6 months. Treatment groups were balanced, with age averaging 64 (SD=10) years; 89% of the patients were male. Azithromycin reduced a global rank sum score of the 4 inflammatory markers at 6 (but not 3) months (P=0. 011) as well as the mean global rank sum change score: 531 (SD=201) for active drug and 587 (SD=190) for placebo (P=0.027). Specifically, change-score ranks were significantly lower for CRP (P=0.011) and IL-6 (P=0.043). Antibody titers were unchanged, and number of clinical cardiovascular events at 6 months did not differ by therapy (9 for active drug, 7 for placebo). Azithromycin decreased infections requiring antibiotics (1 versus 12 at 3 months, P=0.002) but caused more mild, primarily gastrointestinal, adverse effects (36 versus 17, P=0.003). CONCLUSIONS: In CAD patients positive for C pneumoniae antibodies, global tests of 4 markers of inflammation improved at 6 months with azithromycin. However, unlike another smaller study, no differences in antibody titers and clinical events were observed. Longer-term and larger studies of antichlamydial therapy are indicated.  (+info)

Near-patient test for C-reactive protein in general practice: assessment of clinical, organizational, and economic outcomes. (6/7727)

BACKGROUND: The benefits of near-patient, point-of-care tests have not been fully examined. We have assessed the clinical, organizational, and economic outcomes of implementing a near-patient test for C-reactive protein (CRP) in general practice. METHODS: In a randomized crossover trial during intervention periods, general practitioners (GPs) were allowed to measure CRP within 3 min, using NycoCard(R) CRP. During control periods, they had to mail blood samples for CRP measurements to the hospital laboratory and received test results 24-48 h later. Twenty-nine general practice clinics participated (64 GPs), and 1853 patients were included in the study. Results were evaluated at both the level of participating GPs and the level of included patients. RESULTS: For participating GPs, the overall use of erythrocyte sedimentation rates (ESRs) decreased by 8% (95% confidence interval, 1-14%) during intervention periods, and the number of blood samples mailed to the hospital laboratory decreased by 6% (1-10%). No reduction in the prescription of antibiotics was seen. The proportion of study patients having a follow-up telephone consultation was reduced from 63% to 53% (P = 0. 0001), and patients with CRP concentrations >50 mg/L had their antibiotic treatments started earlier when CRP was measured in general practices (P = 0.0161). CONCLUSION: The implementation of the near-patient CRP test was cost-effective mainly on the basis of a reduction in the use of services from the hospital laboratory by GPs. If the implementation is followed by education and clinical guidelines, opportunities exist for additional reduction in the use of ESR and for a more appropriate use of antibiotics.  (+info)

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (7/7727)

BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection.  (+info)

Leptin elimination in hyperleptinaemic peritoneal dialysis patients. (8/7727)

BACKGROUND: Elevated plasma concentrations of leptin, a hormone thought to regulate body composition by influencing food intake/metabolic rate, are prevalent in renal failure patients. The mechanism for these increases is not known, but evidence suggests that simple accumulation due to decreased elimination is insufficient explanation. METHODS: We studied the incidence of hyperleptinaemia in 28 end-stage renal disease patients treated with continuous ambulatory peritoneal dialysis (CAPD), compared with body-mass-index-and sex-matched controls. Results were separated by gender because women have higher leptin concentrations than men. Excretion of leptin and other substances in dialysis fluid was also studied. RESULTS: Hyperleptinaemia was prevalent in women CAPD subjects, but not in men. Plasma leptin concentrations correlated strongly with the daily excretion of leptin in dialysis fluid. Clearance of leptin in dialysis fluid was greater in men than women CAPD subjects. Single regression analysis found that fasting insulin, glucose content of dialysis fluid, plasma albumin, C-reactive protein, erythropoietin dose, urinary creatinine clearance and plasma beta2-microglobulin were not determinants of plasma leptin concentrations. Stepwise forward multiple regression, examining the dependence of plasma leptin on body mass index, renal creatinine clearance, plasma albumin, daily dialysis fluid glucose load, daily leptin in dialysis fluid, erythropoietin dose and plasma C-reactive protein found only erythropoietin dose as a consistent negative predictor of plasma leptin concentrations. CONCLUSIONS: The results suggest that hyperleptinaemia of CAPD was due to predisposing loss of renal elimination capacity combined with increased production due to obesity (more prevalent in women subjects of this study) and potentially female gender.  (+info)

*C-reactive protein

MedlinePlus Encyclopedia C-reactive protein Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein (American ... acute phase erythrocyte sedimentation rate C-reactive protein C-reactive protein GRCh38: Ensembl release 89: ENSG00000132693 - ... "Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares ... C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response ...

*Reference ranges for blood tests

"C-reactive protein". GPnotebook. 2730 Serum C-Reactive Protein values in Diabetics with Periodontal Disease A.R. Choudhury, and ... Acute phase proteins are markers of inflammation. Autoantibodies are usually absent or very low, so instead of being given in ... Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. If ... Electrolytes and Metabolites: For iron and copper, some related proteins are also included. Cardiology diagnostic tests and ...

*Immune reconstitution inflammatory syndrome

... elevated C-reactive protein; failure to sterilize the CSF before immune recovery. IRIS may be the cause of paradoxically worse ... Magnetic resonance imaging shows increase in the size of brain lesions, and CSF abnormalities (white cell count, protein, ...

*Kawasaki disease

C-reactive protein will be elevated. Liver function tests may show evidence of hepatic inflammation and low serum albumin ... Urinalysis may show white blood cells and protein in the urine (pyuria and proteinuria) without evidence of bacterial growth. ...

*Calorie restriction

Risk factors such as c-reactive protein; serum triglycerides, low-density lipoprotein, high-density lipoprotein; blood pressure ... Attempts are being made to develop drugs that act as CR mimetics, and much of that work has focused on a class of proteins ... In late adulthood, acute CR partially or completely reverses age-related alterations of liver, brain and heart proteins, and ... Tapia, P (2006). "Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may ...

*Inflammation

These proteins include C-reactive protein, serum amyloid A, and serum amyloid P, which cause a range of systemic effects ... C-reactive protein (CRP) is generated at a higher level in obese people. It raises when there is inflammation throughout the ... "C-Reactive Protein (CRP) Testing for Heart Disease". WebMD. Retrieved 2017-06-04. Shoelson, SE; Lee, J; Goldfine, AB (July 2006 ... In addition, low-grade chronic inflammation, as indicated by levels of the inflammatory marker C-reactive protein, ...

*Acute prostatitis

C-reactive protein is elevated in most cases. Prostate biopsies are not indicated as the (clinical) features (described above) ...

*Long-term effects of alcohol consumption

Also, serum levels of C-reactive protein (CRP), a marker of inflammation and predictor of CHD (coronary heart disease) risk, ... Stewart, SH.; Mainous, AG.; Gilbert, G. (2002). "Relation between alcohol consumption and C-reactive protein levels in the ... Albert MA, Glynn RJ, Ridker PM (January 2003). "Alcohol consumption and plasma concentration of C-reactive protein". ... Jan 2003). "Alcohol consumption and plasma concentration of C-reactive protein". Circulation. 107 (3): 443-7. doi:10.1161/01. ...

*Periodontitis

... has been linked to increased inflammation in the body, such as indicated by raised levels of C-reactive protein ... Paraskevas, Spiros; Huizinga, John D.; Loos, Bruno G. (2008). "A systematic review and meta-analyses on C-reactive protein in ... D'Aiuto, Francesco; Ready, Derren; Tonetti, Maurizio S. (2004). "Periodontal disease and C-reactive protein-associated ...

*Saliva testing

All of these methods enable detection of specific molecules like cortisol, C-reactive protein (CRP), or secretory IgA. This ... In 2011 Punyadeera, et al., studied "the clinical utility of salivary C-reactive protein levels in assessing coronary events ... September 2010). "Association of salivary lysozyme and C-reactive protein with metabolic syndrome". J. Clin. Periodontol. 37: ... "One-step homogeneous C-reactive protein assay for saliva". J. Immunol. Methods. 373: 19-25. doi:10.1016/j.jim.2011.07.013. PMID ...

*Adiposopathy

... acute phase proteins / reactants such as C-reactive protein; (3) adipokines of the alternative complement system; (4) ... such as C-Reactive protein, interleukin-6, and tumor necrosis alpha) with weight gain Abnormalities in lipoprotein particle ...

*HIST1H1A

"Entrez Gene: HIST1H1A histone cluster 1, H1a". Du Clos TW, Zlock LT, Marnell L (1991). "Definition of a C-reactive protein ... Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene. Histones are basic nuclear proteins responsible for ... 2000). "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein". J. Biol. Chem. ... 2004). "Identification of chromatin-related protein interactions using protein microarrays". Proteomics. 3 (11): 2101-7. doi: ...

*Carol V. Robinson

"Targeting C-reactive protein for the treatment of cardiovascular disease". Nature. 440 (7088): 1217-1221. Bibcode:2006Natur. ... where she began analysing protein folding.Her research on the three-dimensional structure of proteins in particular has ... Marsh, J. A.; Hernández, H; Hall, Z; Ahnert, S. E.; Perica, T; Robinson, C. V.; Teichmann, S. A. (2013). "Protein complexes are ... Miranker, A; Robinson, C. V.; Radford, S. E.; Aplin, R. T.; Dobson, C. M. (1993). "Detection of transient protein folding ...

*Waterhouse-Friderichsen syndrome

C-reactive protein levels can be elevated or almost normal. Thrombocytopenia is sometimes extreme, with alteration in ... Leukocytosis Acidosis Hyperkalemia Hyponatremia Abnormal complete blood count Acute kidney injury C reactive protein Acth test ...

*SnRNP70

Du Clos TW (1989). "C-reactive protein reacts with the U1 small nuclear ribonucleoprotein". J. Immunol. 143 (8): 2553-9. PMID ... 1999). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein ... Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to ... Cao W, Garcia-Blanco MA (1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/ ...

*HIST1H2AL

"Entrez Gene: HIST1H2AL histone cluster 1, H2al". Du Clos TW, Zlock LT, Marnell L (1991). "Definition of a C-reactive protein ... Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene. Histones are basic nuclear proteins that are ... 1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex". Mol. Cell. ... 1999). "Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin". Mol. Cell. Biol. 19 (3): ...

*Giant-cell arteritis

C-reactive protein, another inflammatory marker, may be elevated.[citation needed] Platelets may also be elevated.[citation ...

*Genome-wide association study

Danesh J, Pepys MB (November 2009). "C-reactive protein and coronary disease: is there a causal link?". Circulation. 120 (21): ... Moreover, the researchers try to integrate GWA data with other biological data such as protein protein interaction network to ... Ayati M, Erten S, Chance MR, Koyutürk M (December 2015). "MOBAS: identification of disease-associated protein subnetworks using ... November 2011). "Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 ...

*Pentraxins

C-reactive protein (CRP), serum amyloid P component protein (SAP), and female protein (FP). PTX3 (or TSG-14) protein is a ... C-reactive protein is expressed during acute phase response to tissue injury or inflammation in mammals. The protein resembles ... are an evolutionary conserved family of proteins characterised by containing a pentraxin protein domain. Proteins of the ... Romero IR, Morris C, Rodriguez M, Mold C, Du Clos TW (1998). "Inflammatory potential of C-reactive protein complexes compared ...

*Meningitis

If someone is suspected of having meningitis, blood tests are performed for markers of inflammation (e.g. C-reactive protein, ... The CSF sample is examined for presence and types of white blood cells, red blood cells, protein content and glucose level. ... Development of a vaccine against group B meningococci has proved much more difficult, as its surface proteins (which would ... cloudy CSF indicates higher levels of protein, white and red blood cells and/or bacteria, and therefore may suggest bacterial ...

*CHI St. Luke's Health

The next year, Texas Heart Institute became the first to demonstrate that C-Reactive Protein (CRP) causes vascular inflammation ... Ridker, MD, Paul M. "C-Reactive Protein, Inflammation, and Cardiovascular Disease". Tex Heart Inst J. 32: 384-6. PMC 1336715 . ...

*Myeloperoxidase

study reported that measuring both MPO and CRP (C-reactive protein; a general and cardiac-related marker of inflammation) ... Heslop CL, Frohlich JJ, Hill JS (Mar 2010). "Myeloperoxidase and C-reactive protein have combined utility for long-term ... The protein forms a deep crevice which holds the heme group at the bottom, as well as a hydrophobic pocket at the entrance to ... The 150-kDa MPO protein is a cationic homodimer consisting of two 15-kDa light chains and two variable-weight glycosylated ...

*Anders Dale

2015). "Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease". Circulation. 131 (23): 2061-2069. ...

*Lymphoma in animals

This test utilises the acute phase proteins (C-Reactive Protein and Haptoglobin). In combination with basic clinical symptoms, ... Serum thymadine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease. K A ... Hypercalcemia in these cases is caused by secretion of parathyroid hormone-related protein. Multicentric lymphoma presents as ...

*Cleopatra Abdou

... and C-reactive protein: A moderated-mediation analysis". Health Psychology. 29: 307-316. doi:10.1037/a0019286. Abdou, C.M; ...

*Phage display

... is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... Barbas CF, Languino LR, Smith JW (November 1993). "High-affinity self-reactive human antibodies by design and selection: ... a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on ... characterize small molecules-protein interactions and map protein-protein interactions. Users can use three dimensional ...
Using a prospective cohort study of 2,910 Danish women with invasive breast cancer, we have demonstrated that elevated CRP levels at the time of diagnosis of breast cancer were associated with reduced overall and disease-free survival and with increased risk of death from breast cancer. These are novel observations.. Mechanistically, three components might explain the observed association between elevated CRP levels and poor breast cancer prognosis. First, tumour cell behavior: plasma CRP levels may reflect the aggressiveness of the tumour, that is, plasma CRP levels might sum up some prognostic information of well-known tumour characteristics, such as tumour stage and grade. In the present study, elevated CRP levels were indeed associated with larger tumour size, presence of distant metastases, and lower tumour grade (although CRP was not linearly associated with tumour grade), and these prognostic factors were associated with poor prognosis. Second, adjacent inflammation: plasma CRP levels ...
Background. Cardiac Magnetic Resonance Imaging (CMR) can identify myocardial damage due to embolization after percutaneous coronary interventions (PCI). Late Gadolinium Enhancement (LGE) can non-invasively detect myocardial fibrosis however the association of High sensitive C-reactive protein (HS-CRP) or Neopterin levels with myocardial damage in PCI is currently unknown.. Methods. Patients admitted with potential PCI were enrolled. LGE CMR scan was performed 24hours pre- and 24 hours post-PCI. Fourty five patients were enrolled, 61±12 yrs old, 33(73%) male. CMR performed pre PCI failed to show LGE in the area of the target vessel. TnI were not elevated at baseline. New LGE areas in the 2nd CMR scan were classified in distal (, 10 mm downstream from the stent) or adjacent (close to the stent). Troponin I was assessed at baseline and at 12 and 24 hours after PCI.. Results. In 35 out of 45 pts, baseline levels of HS-CRP and neopterin were measured.Troponin I elevation occurred in 26 (58%) ...
The results of the present study demonstrate for the first time that elevated CRP levels are associated with a profound impairment in systemic endothelial vascular reactivity in patients with coronary artery disease. The blunted systemic endothelial vasodilator function related to elevated plasma CRP levels is independent of classic risk factors for coronary artery disease. Most importantly, normalization of CRP levels over time is associated with a significant improvement in endothelium-dependent FBF responses. These findings support the concept that alterations in endothelial cell function may provide a link between systemic inflammation and ischemic coronary events.. It is well established that atherosclerosis impairs endothelial vasodilator function in both the coronary18 and the forearm circulation. Moreover, chronic risk factors for coronary artery disease have been shown to adversely affect endothelium-dependent blood flow responses in the human forearm circulation.19 20 However, the ...
Two cross-sectional studies of adults showed no association between CRP levels and carotid intima-medial thickness (IMT) measured by ultrasound.21,22 Two other studies found no association between serum CRP and coronary artery calcification.23,24 The Framingham Study found an association between CRP and internal carotid IMT (but not common carotid IMT) only in women.25. CRP levels were higher in subjects dying with, but not resulting from, severe coronary atherosclerosis, and were also higher in subjects dying because of recent coronary thrombosis without infarction, than in subjects dying from noncardiovascular causes with minimal coronary atherosclerosis.26 Immune reactivity to heat shock proteins, but not CRP concentration, was associated with carotid and femoral IMT in young (17 to 18 years) men.27 Human transgene expression accelerated aortic atherosclerosis in apolipoprotein E-deficient mice.28. The AHA classification system is based on a temporal sequence that is deduced from lesions ...
BackgroundInflammation and microvascular dysfunction (MVD) are independently associated with adverse cardiovascular outcomes in patients with ischaemic heart disease. This study aimed to assess the relationship between inflammation, MVD and myocardial injury.MethodsCoronary microvascular function was assessed in 74 patients undergoing percutaneous coronary intervention (PCI) using the index of microvascular resistance (IMR) by a pressure-temperature sensor-tipped wire. Serum high-sensitivity C-reactive protein (hsCRP) level was quantified by rate turbidimetry. Severe MVD was defined as IMR|30. Pearson correlation was computed to assess the relationships between hsCRP, troponin and IMR of culprit vessel. Predictors of severe MVD were assessed by regression analysis. ResultsAcute coronary syndromes (ACS) represented 49% of the total cohort. Study cohort was divided into Low CRP (hsCRP3mg/L) groups. There was higher representation of smokers (78% vs. 52%), diabetics (39% vs. 18%) and ACS (61% vs. 33%), as
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).. Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.. Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic inflammatory and cardiovascular diseases, smokers or on antiplatelet therapy were excluded. In all the 178 subjects (65.2±10.7 years, 71 men and 107 women) enrolled, we measured hs-CRP, waist circumference (WC), fasting plasma glucose (FPG), systolic and diastolic blood pressure, high density lipoprotein-cholesterol (HDL-Ch), triglycerides (TGs), and 24 h. Albumin excretion (ALB-e). The MS was defined according to the IDF criteria. Student s t-test was used to compare the means, and the Mann Whitney U test to analyze the relationship between hs-CRP levels and the presence of ...
The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin (P for trend = .007), pyridoxine (P for trend = .042), and cobalamin (P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin (P for trend = .084) and pyridoxine (P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile.. CONCLUSION ...
Lupus and elevated c reactive protein levels - Whatcauses high c-reactive protein ihave IBS andfamily history of lupus could either of these be the cause? CRP. Is just a marker for inflammation whatever the cause.
C-reactive protein is a sensitive but nonspecific systemic marker of inflammation. Several prospective studies have investigated the association of prediagnostic circulating C-reactive protein concentrations with the development of colorectal cancer, but the results have been inconsistent. We performed a systematic review of prospective studies of the association between prediagnostic measurements of circulating high-sensitivity C-reactive protein and development of invasive colorectal cancer. Authors of original studies were contacted to acquire uniform data. We combined relative risks (RR) for colorectal cancer associated with a one unit change in natural logarithm-transformed high-sensitivity C-reactive protein using inverse variance weighted random effects models. We identified eight eligible studies, which included 1,159 colorectal cancer cases and 37,986 controls. The summary RR per one unit change in natural log-transformed high-sensitivity C-reactive protein was 1.12 (95% confidence intervals
TY - JOUR. T1 - Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. AU - Soedamah-Muthu, S.S.. AU - Livingstone, Shona J.. AU - Charlton-menys, Valentine. AU - Betteridge, D. John. AU - Hitman, Graham A.. AU - Neil, H. Andrew W.. AU - Bao, Weihang. AU - Demicco, David A.. AU - Preston, Gregory M.. AU - Fuller, John H.. AU - Stehouwer, Coen D. A.. AU - Schalkwijk, Casper G.. AU - Durrington, Paul N.. AU - Colhoun, Helen M.. PY - 2015/7/1. Y1 - 2015/7/1. U2 - 10.1007/s00125-015-3586-8. DO - 10.1007/s00125-015-3586-8. M3 - Article. VL - 58. SP - 1494. EP - 1502. JO - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. JF - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. SN - 0012-186X. IS - 7. ER - ...
C-reactive protein has been used to identify patients at high risk for infectious morbidity with preterm labor or preterm rupture of membranes. In this article we report on 104 patients with preterm labor symptoms (n = 45) or preterm rupture of the membranes (n = 59) and serial evaluations of C-reactive protein measured by latex agglutination and laser nephelometry. The simple, inexpensive latex method appears comparable to the laser method in predicting infectious morbidity and can be used clinically. Elevated C-reactive protein values before delivery predict infectious morbidity in only 8% to 29% of patients, and up to 18% of patients with serious infections may be misdiagnosed as having normal C-reactive protein values before delivery.
Kovacs, A, Green, F, Hansson, LO, Lundman, P, Samnegard, A, Boquist, S, Ericsson, CG, Watkins, HH, Hamsten, A and Tornvall, P (2005) A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein ...
Background and Purpose- Recent studies described an association between elevated levels of C-reactive protein (CRP) and outcome after ischemic stroke. We investigated the impact of early serial CRP measurements in hyperacute ischemic stroke on long-term outcome.. Methods- One hundred twenty-seven consecutive patients without thrombolysis with a first ischemic stroke no more than 12 hours after symptom onset were examined. Serial CRP measurements were done at admission (CRP 1), within 24 hours (CRP 2), and within 48 hours (CRP 3) after symptom onset. In addition to several cerebrovascular risk factors, the 1-year outcome and the lesion volumes of initial diffusion-weighted images were determined.. Results- The CRP concentration increased significantly during the first 48 hours after symptom onset (CRP 1, 0.86 mg/dL [95% CI, 0.69 to 1.02]; CRP 2, 1.22 mg/dL [95% CI, 0.88 to 1.55]; CRP 3, 1.75 mg/dL [95% CI, 1.25 to 2.25]; P=0.003). Multiple logistic regression analysis identified Barthel Index ...
Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients - Volume 101 Issue 8 - An Pan, Wendy Demark-Wahnefried, Xingwang Ye, Zhijie Yu, Huaixing Li, Qibin Qi, Jianqin Sun, Yanqiu Chen, Xiafei Chen, Yong Liu, Xu Lin
Serum concentrations of CRP increase several hundredfold in response to bacterial infection, making it an attractive diagnostic test for neonatal sepsis. Because many of the more than 70 publications on this subject that have appeared during the past 30 years were flawed by imprecise diagnostic criteria, absent or inappropriate controls (eg, healthy neonates), incomplete description of results, or inadequate sample sizes, the role of this test in evaluation of neonates remains controversial. Early reports described a high prevalence of elevated CRP levels in infected infants, but levels are elevated in only 35% to 65% of neonates with bacterial infection at the onset of illness. Recognition that a delay of at least several hours is intrinsic to the cascade of events leading to elevation of serum CRP levels (including activation of neutrophils, elaboration of interleukin-6, and induction of hepatic synthesis of CRP) led to appropriate criticism of this test as having insufficient sensitivity to ...
As an acute-phase protein, human C-reactive protein (CRP) is clinically important. CRPs were purified from several samples in six different pathological conditions, where their levels ranged from 22 to 342 μg/ml. Small, but significant, variations in electrophoretic mobilities on native PAGE suggested differences in molecular mass, charge and/or shape. Following separation by SDS/PAGE, they showed single subunits with some differences in their molecular masses ranging between 27 and 30.5 kDa, but for a particular disease, the mobility was the same for CRPs purified from multiple individuals or pooled sera. Isoelectric focusing (IEF) also indicated that the purified CRPs differed from each other. Glycosylation was demonstrated in these purified CRPs by Digoxigenin kits, neuraminidase treatment and binding with lectins. The presence of N-linked sugar moiety was confirmed by N-glycosidase F digestion. The presence of sialic acid, glucose, galactose and mannose has been demonstrated by gas liquid ...
(2014) Magro et al. Journal of Crohns and Colitis. Background: Infliximab (IFX) is effective in treating Crohns disease (CD) and C-reactive protein (CRP) is a useful biomarker in assessing inflammatory activity. Aim: Correlate CRP levels before beginning of IFX, at week 14 and CRP delta within ...
C-reactive protein (CRP) is an acute-phase reactant frequently used in histochemistry like a marker of ongoing inflammation. [AA] 218 to 232) was identified by CP-724714 monoclonal antibodies CRP-8 and 9C9. This epitope region of Hsp60 displays 26.6% amino acid identity to CRP AA region 77 to 90. These data suggest that the B-cell epitopes shared between CRP and Hsp60 give rise to a true mimicry-based cross-reaction and the induction of cross-reactive antibodies. Our study underlines the importance of thorough study design and careful interpretation of results while using polyclonal anti-CRP antibodies for histochemistry, especially at low dilutions. Furthermore, analytical interference with Hsp60 in CRP assays should also become tested. C-reactive protein (CRP) is an acute-phase reactant in humans, rabbits, and a number of additional mammalian varieties. It is indicated and secreted primarily by hepatocytes, but recently, local production at sites of swelling by monocytes has also been reported ...
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.
We recruited a random sample of men aged 50-69 years from the registers of general practices in the Merton, Sutton, and Wandsworth District Health Authority area, south London. A total of 612 men were invited and 413 (67%) attended. Of these, 25 were non-white and were excluded. Information was obtained on history and symptoms of coronary heart disease, lifestyle, and socioeconomic circumstances, as described previously. Cardiovascular risk factor profiles and serological tests for H pylori and C pneumoniae were also performed as described.11 Electrocardiograms were Minnesota coded. We took tracings to indicate coronary heart disease if they showed any of the following: Q waves, ST segment depression, left bundle branch block, or T wave inversion. Only the 303 men who had complete cardiovascular risk factor profiles were included in the study.. C Reactive protein concentration was measured by in house enzyme linked immunosorbent assay (ELISA). Rabbit antihuman C reactive protein (Dako) was used ...
Results The prevalence of RCT was higher in patients with HOA group (192/307, 62.5%) than those without HOA (410/827, 49.5%, p,0.010). Among 307 with HOA, patients with RCT were older (62.69±7.04 vs. 59.11 ±7.69, p,0.001) and showed higher hs-CRP (1.51±3.78 vs. 0.67±0.70, p=0.004) and lower HDL levels (55.66±15.46 vs. 60.48±12.45, p=0.003) compared to those without RCT. There were no significant differences in gender, smoking, comorbidities, work period, body mass index, number of affected joints, HOA severity, and prevalence of erosive HOA between both groups. Multiple logistic regression analysis showed significant associations of age (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.02 - 1.10), serum levels of hsCRP (OR 1.37, CI 1.04 - 1.80), and HDL (OR 2.13, CI 1.14 - 3.98) with RCT in HOA patients. ...
C-reactive proteins are proteins that identify viral and bacterial infections that can cause inflammation. They are also used in identifying colon cancer and pulmonary disease. Normal C-reactive proteins have a protein structure that resembles a jellyroll. C-reactive proteins are part of the pentraxin family and were first identified by Tillet and Frances.
A study of the association of Herpes simplex virus 1 and 2 exposure to early atherosclerosis using high C-reactive protein level as a marker was carried out in US born, non-pregnant, 20-49 year olds participating in a national survey between 1999 and 2004. Participants were required to have valid results for Herpes simplex virus 1 and 2 and C-Reactive Protein for inclusion. Cases were those found to have a high C-reactive protein level of 0.3-1 mg/dL, while controls had low to normal values (0.01-0.29 mg/dL). Overall, there were 1211 cases and 2870 controls. Mexican American and non-Hispanic black women were much more likely to fall into the high cardiac risk group than the other sex race groups with proportions of 44% and 39%, respectively. ^ Herpesvirus exposure was categorized such that Herpes simplex virus 1 and 2 exposure could be studied simultaneously within the same individual and models. The HSV 1+, HSV 2- category included the highest percentage (45.63%) of participants, followed by HSV 1-,
Description of disease C-Reactive Protein Test (CRP). Treatment C-Reactive Protein Test (CRP). Symptoms and causes C-Reactive Protein Test (CRP) Prophylaxis C-Reactive Protein Test (CRP)
Use of statin and/or aspirin therapy had negligible effects on the comparisons with the HNF1A-MODY group (Table 1). In the type 2 diabetic group, the hs-CRP level was the same for the statin/aspirin users as for the nonusers (P = 0.27), whereas in the type 1 diabetic group those taking statins and/or aspirin had a higher hs-CRP than nonusers (P = 0.004). Thus, it seems unlikely that use of these drugs would lower hs-CRP toward the range seen in the HNF1A-MODY group. In contrast, adjustment for BMI had a large impact on the estimated means (Table 1) and, given the correlation between BMI and CRP (r2 = 0.28, P , 10−6 for control subjects), abolished much of the difference observed between the type 2 diabetic and other groups. However, the differ- ences in hs-CRP levels between the HNF1A-MODY and other groups were preserved (P ≤ 0.01). Estimated mean adjusted hs-CRP (95% CI) levels for the HNF1A-MODY group compared with the other diabetic groups combined were 0.28 (0.16-0.49) vs. 0.82 ...
Porcine C-Reactive Protein/CRP ELISA Kit (Colorimetric). High sensitivity ELISA kit for detection of C-Reactive Protein/CRP. Backed by our 100% Guarantee.
PubMed journal article Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrom were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Prognostic role of serum C-reactive protein in esophageal cancer: a systematic review and meta-analysis Ying Huang,1 Ji-Feng Feng,2 Jin-Shi Liu,2 Qi-Xun Chen21Department of Operating Theatre, 2Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaBackground: Recent studies have shown that C-reactive protein (CRP) is a useful predictive factor in several cancers; however, its role in esophageal cancer (EC) is controversial.Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I2
Background: C-reactive protein (CRP) is often used as a clinical marker of acute systemic inflammation. Since low grade inflammation is evident in chronic diseases such as chronic obstructive pulmonary disease (COPD), new methods have been developed to enhance the sensitivity of CRP assays in the lower range. A study was undertaken to investigate the discriminative value of high sensitivity CRP in COPD with respect to markers of local and systemic impairment, disability, and handicap. Methods: Plasma CRP levels, interleukin 6 (IL-6) levels, body composition, resting energy expenditure (REE), exercise capacity, health status, and lung function were determined in 102 patients with clinically stable COPD (GOLD stage II-IV). The cut off point for normal versus raised CRP levels was 4.21 mg/l. Results: CRP levels were raised in 48 of 102 patients. In these patients, IL-6 ( ...
A 5 year old boy is brought to the accident and emergency department with pain in his left leg. The previous day he limped markedly and now he refuses to walk. History is negative for injury and positive for fever in a previously well, immunised child who is developmentally normal. Concerned about septic arthritis, the junior doctor requests a blood count, erythrocyte sedimentation rate, and C reactive protein concentration, and requests review by the paediatric team. ...
However, a low CRP level does not always mean that there is no inflammation present. Levels of CRP may not be increased in people with rheumatoid arthritis and lupus. The reason for this is unknown.. A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a persons risk for heart disease. Many consider a high CRP level to be a risk factor for heart disease. However, it is not known whether CRP is merely a sign of cardiovascular disease or if it actually plays a role in causing heart problems.. ...
Serum C-reactive protein (CRP) concentration was measured by a new solid phase ligand-binding radiometric monoclonal antibody immunoassay in a prospective study of 193 consecutively born preterm infants. In 104 with no clinical or laboratory evidence of infection the median CRP in cord serum was 0.125 mg/l (range 0.011-6.0 mg/l), at 24 h it was 1 mg/l (0.016-7.0) and at 48 h 2 mg/l (0.400-8.0). The present highly sensitive assay has enabled these normal ranges to be defined for the first time, at levels below the threshold of non-labelled immunoassays and of all commercially available CRP assays. The values in cord serum were significantly lower than in normal healthy adults (median 0.8 mg/l, range 0.07-29 mg/l, n = 468). Arterial catheterisation and endotracheal intubation, in the absence of infection, did not appear to elevate CRP, nor did cerebral germinal layer or intraventricular haemorrhage. Among nine infants with confirmed septicaemia eight had a serum CRP level raised at least once ...
The present study was undertaken to assess plasma C-reactive protein levels in pregnant women with and without periodontal disease. The study was designed as a prospective cohort study involving a sample size of 45 pregnant subjects in the age of 20-40 were selected from RavindraNath Tagore Medical College and hospital with gestational age of 2-12 weeks divided into 3 groups : Control group (15 healthy non pregnant female without periodontitis; group A; study group - 15 pregnant females with periodontitis - group B) study group (15 pregnant patients without periodontitis) Group C. Periodontal disease activity was recorded at baseline for all groups using month mirror and UNC-15 periodontal probe and Russells Index was recorded. Samples were taken for estimation of C-reactive protein levels from all groups at 2-12 weeks of gestation. CRP levels were determined using latex-agglutination-test. The results revealed a statistically significant increase in the levels of CRP in pregnant women with ...
Purpose: We aimed to establish an inflammatory prognostic index (IPI) in early and advanced non-small cell lung cancer (NSCLC) patients based on hematologic and biochemical parameters and to analyze its predictive value for NSCLC survival. Materials and Methods: A retrospective review of 685 patients with early and advanced NSCLC diagnosed between 2009 and 2014 was conducted with collection of clinical, and laboratory data. The IPI was calculated as C-reactive protein × NLR (neutrophil/ lymphocyte ratio)/serum albumin. Univariate and multivariate analyses were performed to assess the prognostic value of relevant factors. Results: The optimal cut-off value of IPI for overall survival (OS) stratification was determined to be 15. Totals of 334 (48.8%) and 351 (51.2%) patients were assigned to high and low IPI groups, respectively. Compared with low IPI, high IPI was associated with older age, greater tumor size, high lymph node involvement, distant metastases, advanced stage and poor performance status.
The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that finds lower levels of C-reactive protein (CRP). This protein measures general levels of inflammation in your body. The hs-CRP can be used to find the risk for heart disease and stroke in people who dont already have heart disease. It can also be used to help predict how well a person who has heart disease might recover or to predict how the person might respond to treatment. The hs-CRP test is different than the standard CRP test. The standard test measures high levels of the protein to find different diseases that cause inflammation. The hs-CRP test measures low levels and focuses on the risk of heart disease and stroke. ...
Most tissue-damaging processes such as infections, inflammatory diseases and malignant neoplasms are associated with a major acute phase response of the C-reactive protein (CRP) and other acute reactants e.g. AAT, AAGP, C3C, C4 HAPT. The CRP response frequently precedes clinical symptoms, including fever. In normal healthy individuals CRP is a trace protein with a range up to 5 mg/L. After onset of an acute phase response the serum CRP concentration rises rapidly and extensively. Levels of up to thousand times the normal value are associated with severe stimuli such as myocardial infarction, major trauma, surgery or malignant neoplasm. CRP has a half-life of only a few hours, making it an ideal tool for clinical monitoring ...
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More subtle, early indicators of problems could include headaches, muscles aches, fatigue, muscle stiffness, nausea, vomiting, diarrhea or constipation, gas, abdominal discomfort and even emotional problems including depression. These could be related to food sensitivities and intolerances. The most common food intolerances include dairy (lactose), wheat (gluten), yeast, soy, corn, eggs and even some artificial sweeteners.. How can you know if you have chronic inflammation if you dont have symptoms or a diagnosis?. You can find out if you have inflammation by having your C- reactive protein levels tested. The high sensitivity C-reactive protein, is the preferred indicator of chronic, low-grade inflammation.. What should I do if I have high levels of C-reactive protein?. If your C-reactive protein levels are high, you will first want to talk to your doctor to find out if there is an underlying infection, allergy, autoimmune disorder or other contributing disease. If not, your excess weight could ...
TY - JOUR. T1 - Gender and C-reactive protein. T2 - Data from the Multiethnic Study of Atherosclerosis (MESA) cohort. AU - Lakoski, Susan G.. AU - Cushman, Mary. AU - Criqui, Michael. AU - Rundek, Tatjana. AU - Blumenthal, Roger S.. AU - DAgostino, Ralph B.. AU - Herrington, David M.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Background: American Heart Association/Centers for Disease Control and Prevention guidelines support the measurement of C-reactive protein (CRP) to further risk stratify individuals at intermediate risk (10%-20% 10-year risk) for heart disease. Determining gender-specific differences in CRP may alter how CRP levels are interpreted and used to determine risk. Methods: MESA is a prospective cohort consisting of 6814 men and women aged 45 to 84 years recruited from 6 US communities. Nonparametric analyses were performed to determine differences in CRP levels by gender in the entire cohort and after stratifying by use of estrogen medication (n = 944). Stratifying by median body mass ...
Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes. Kahn, Steven E.; Zinman, Bernard; Haffner, Steven M.; ONeill, M. Colleen; Kravitz, Barbara G.; Yu, Dahong; Freed, Martin I.; Herman, William H.; Holman, Rury R.; Jones, Nigel P.; Lachin, John M.; Viberti, Giancarlo C. // Diabetes;Aug2006, Vol. 55 Issue 8, p2357 The inflammatory factor C-reactive protein (CRP) and the fibrinolytic variables fibrinogen and plasminogen activator-1 (PAI-1) are associated with long-term cardiovascular morbidity. To determine the contribution of body adiposity (BMI), insulin sensitivity (homeostasis model assessment of... ...
BACKGROUND: Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances. METHODS: We meta-analysed individual records of 160 309 people without a history of vascular disease (ie, 1.31 million person-years at risk, 27 769 fatal or non-fatal disease outcomes) from 54 long-term prospective studies. Within-study regression analyses were adjusted for within-person variation in risk factor levels. RESULTS: Log(e) CRP concentration was linearly associated with several conventional risk factors and inflammatory markers, and nearly log-linearly with the risk of ischaemic vascular disease and non-vascular mortality. Risk ratios (RRs) for coronary heart disease per 1-SD higher log(e) CRP concentration (three-fold higher) were 1.63 (95% CI 1.51-1.76) when initially adjusted for age
C-reactive protein is a serum acute-phase reactant that increases several thousand-fold in concentration during inflammation in most mammals. However, mouse C-reactive protein is considered to be a minor acute-phase reactant, since its blood level increases only from approx. 0.1 to 1-2 micrograms/ml. A mouse genomic clone of approximately 5 kb was obtained to determine the molecular basis for the regulation of the expression of mouse C-reactive protein. Several cis-acting elements in the 5′ flanking region that potentially regulate transcription were identified: two glucocorticoid-responsive elements, two CCAAT-enhancer-binding protein C (C/EBP) consensus elements that are required for the interleukin-1 responsiveness of some acute-phase reactant genes, an interleukin-6-responsive element, two hepatocyte nuclear factor-1 (HNF-1) elements and a single heat-shock element. Transfection of the hepatoma cell line Hep 3B.2 with a pCAT expression vector containing the 5′ flanking sequence from ...
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein.
Background: Studies regarding the effects of high protein (HP) diet on cardiovascular (CVD) risk factors have reported contradictory results.. Objective: In present study, we aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.. Design: In this randomized controlled trial, we recruited 60 overweight and obese women, aged 20-65 years into HP or control energy restricted diets for three months (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). Total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. Fasting blood samples, hs-CRP, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines. ...
Results At one-month follow-up, 22 patients (33%) had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.14 to 2.98; p = 0.013) even after adjusting for age (OR 2.22; 95% CI 1.25 to 3.93; p = 0.006), for gender (OR 1.89; 95% CI 1.16 to 3.09; p = 0.011), or duration of arrhythmia (OR 1.86; 95% CI 1.13 to 3.07; p = 0.015). On multivariate analysis, CRP was the only independent predictor of arrhythmia recurrence (OR 2.19; 95% CI 1.05 to 4.55; p = 0.036). ...
My advice to consumers is do NOT let your primary care doctor confine your annual bloodwork to a minimal Complete Blood Count (CBC) and Lipid Panel. The CRP test should be added to check for risk of heart attacks, homocysteine levels as a marker of stroke risk, 25 hydroxy Vitamin D levels, and the regular Chemistry Panel (liver, kidney functions, proteins, complete metabolic panel).. From Alex Rineharts web page:. "Other Signs of Vascular Inflammation:. ...
An observational, non-interventional, multi-centre study to provide further information on the utility of test for a predictive marker by investigating the current prevalence of high sensitivity CRP (hs-CRP) testing and characteristics of each CVD risk group ...
C-reactive protein (CRP) is a protein that can be measured in your blood. It appears in higher amounts when theres swelling (inflammation) somewhere in your body. Your doctor may check your C-reactive protein level after surgery or treatment for infections or other medical conditions. A C-reactive protein test can also be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can eventually lead to a heart attack.
2 References. Quantikine Mouse C-Reactive Protein/CRP ELISA Kit(MCRP00). Sensitivity: 0.015 ng/mL. Validated for Cell Culture Supernates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma. High precision and reproducibility. View product details.
In this study, we report that type 2 diabetic patients residing in Pune, India, show high concentrations of serum CRP concentrations that correlate positively and significantly with ambient levels of SO2 and NOx, even at levels below the NAAQS. Although ambient PM10 levels exceeded NAAQS on 62% of study days, it did not show significant correlation with CRP concentrations. Among the gaseous pollutants, SO2 showed a stronger association compared with NOx. Moreover, the association was particularly stronger in patients with a shorter (,7 years) duration of time since their diabetes diagnosis, and weaker in those who were receiving statins, aspirin, and TZD, drugs with known anti-inflammatory properties. To the best of our knowledge, this is the first study in this region of the world that has shown a significant association between ambient air pollutants and CRP concentrations in type 2 diabetic patients. Inflammation is a powerful risk factor for CVD in type 2 diabetic patients (28), and our ...
To the Editor: The use of tumor necrosis factor inhibitors (TNFi) for psoriasis was associated with a significant reduction in myocardial infarction incidence and risk,1 and in cardiovascular mortality.2,3 The objective was to assess changes in C-reactive protein (CRP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and alanine aminotransferase (ALT) for patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis exposed to a TNFi with concomitant exposure to methotrexate (MTX) compared with patients exposed to MTX therapy with no TNFi.The full study meth
What is Omega 7? Its Benefits are Lowering Inflammation and C-Reactive Protein. Omega 7 Benefits - Lowers c-reactive protein, LDL Cholesterol, Blood Pressure
ABSTRACT: Chronic low-grade inflammation is involved in the development of diabetes mellitus type 2 (DMT2). Because of genetic inheritance, first-degree relatives of DMT2 patients are at increased risk of developing this metabolic disorder. We aimed to investigate the association of inflammation in the development of DMT2 in siblings of DMT2 patients. Twenty seven DMT2 patients and 27 healthy individuals without a family history of DMT2 were enrolled. Plasma levels of the high sensitive C-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and fibrinogen (FIB), as inflammatory factors were assessed in all individuals. Levels of hs-CRP, TNF-α, IL-6, and FIB were significantly higher in DMT2 patients than in their siblings. Furthermore, all marker levels were found to be significantly higher in the siblings group than in healthy controls. Siblings of DMT2 patients are then at higher risk for DMT2 than healthy controls. Systemic inflammatory abnormalities may play ...
There is no special preparation for a C-reactive protein (CRP) test. You might be asked to not eat or drink for a few hours before the test.. Tell your doctor all of the medicines you are taking because some medicines can affect the results.. Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the medical test information form ( What is a PDF document? ).. ...
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There is an emerging consensus that CHD has a multifactorial etiology, including atherosclerotic, prothrombotic, and inflammatory components. Therefore, beyond the assessment of conventional CHD risk factors, new markers have been explored in prospective observational studies with the hope that they might improve our ability to predict the risk of developing an acute coronary event.. Among those putative new markers of CHD risk, CRP is a major acute-phase protein associated with chronic systemic inflammation and has been suggested to predict CHD risk beyond traditional risk factors.3 4 5 6 7 8 9 CRP has been shown to be associated with the development of CHD events in subjects with3 4 5 and without6 7 8 9 established cardiovascular disease, and case-control prospective studies have suggested that it may be a new independent CHD risk factor.6 7 8 32 However, its exact role in the etiology of CHD remains obscure. CRP may be a marker of the inflammatory component of the atherosclerotic disease ...
Ioannidou, E., Swede, H., Dongari-Bagtzoglou, A. Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease ...
Higher levels of 25-hydroxyvitamin D (25 (OH) D) may lower the risk of anemia and elevated C-reactive protein levels may raise the risk.
Results. ASAS classified 90% of the 231 patients, with 169 (73%) fulfilling all 3 criteria sets. Multivariate analysis showed the 62 patients not fulfilling all criteria sets were older at symptom onset (p , 0.001) and less likely to have inflammatory back pain (p , 0.001), peripheral arthritis (p , 0.001), or elevated C-reactive protein levels (p = 0.034). ...
Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol
Results from the present thesis showed that different measures of body fat distribution differed in their relations to parameters of chronic inflammation. Specifically, VAT, SAT, BMI, and waist circumference (WC) were all associated with high sensitive C-reactive protein (hs-CRP). Additionally, BMI was inversely related to adiponectin and the ratio of visceral to subcutaneous body fat (VSR) was inversely related to resistin. In exploratory subgroup analyses, VAT was the strongest indicator for increased levels of interleukin-6 (IL 6). SAT was the most consistent indicator for increased levels of hs-CRP and BMI was the most consistent indicator for decreased levels of adiponectin. WC represented a weak indicator for increased levels of hs-CRP and decreased levels of adiponectin. In addition, by investigation of the urine and serum metabolom, a more comprehensive approach that does not only focus on single biomarkers was applied in the present thesis. Nuclear magnetic resonance spectroscopy (NMR) ...
The Mayo Clinic research report appears online and in the August issue of the American Journal of Hypertension. The Mayo Clinic collaborative study with researchers from the University of Michigan looked at 214 men and women with an average age of 59, who had no history of heart attack or stroke. Results suggest that low grade inflammation is associated with arterial stiffness (hardening). This inflammation may be a potential mechanism through which C-reactive protein is related to heart attack and stroke, and why testing for C-reactive protein in a blood test may be an effective early warning test for asymptomatic, or presymptomatic heart disease ...
Background: Recent studies have found that there is a strong association between ischemic heart disease (IHD) and hypertension (HTN) with spirometric indices. Aims: To study the prevalence of obstructive airway disease (OAD) in non-smoker subjects with IHD and HTN and to compare them with healthy population. Settings and Design: This was a prospective, case-control, and observational study. Subjects and Methods: A total of 100 patients (cases) (n = 100) admitted in medicine department were recruited for this study. Controls (n = 100) were apparently healthy age- and sex-matched without HTN and IHD, recruited from March 2007 to July 2008. All eligible subjects were subjected to spirometric examination on a turbine-based spirometer (MIR spirolab-II) according to ATS/ERS guidelines. Forced expiratory volume/forced vital capacity (FEV 1 /FVC) ratio ,70% was used to make a diagnosis of OAD. Statistical Analysis Used: All analyses were carried out using Statistical Software Package for Social Sciences ...
Data are presented as mean ± SD or n (%).. ACS = acute coronary syndrome; BMS = bare-metal stent(s); e-GFR = estimated glomerular filtration rate; HDL = high-density lipoprotein; hs-CRP = high sensitive C-reactive protein; LDL = low-density lipoprotein; MACE = major adverse cardiac events; PES = paclitaxel-eluting stent(s); SES = sirolimus-eluting stent(s).. ...
OBJECTIVE: To study the effect of melatonin as an adjuvant therapy in the treatment of neonatal sepsis. METHODS: This study is a prospective nonrandomized nonblind case-control study and was carried on 40 neonates with neonatal sepsis diagnosed by both clinical and laboratory criteria. They were enrolled from the Neonatal Intensive Care Unit, Menoufia University Hospitals. These cases were selected during the study period from November 2015 to May 2016 and were divided into two groups: intervention group (number 20 neonates) received melatonin 20 mg as single dose and antibiotics and control group (number 20 neonates) received antibiotics only and then both groups followed by physical examination, complete blood count (CBC), and high sensitive C-reactive protein (hs-CRP) to evaluate the improvement in both groups ...
PURPOSE: This study aimed to explore the predictive value of systematic inflammatory and metabolic markers in head and neck (H&N) cancer patients during radiotherapy (RT).. METHODS: Twenty-seven patients were evaluated. The protocol included serial blood tests [highly sensitive C-reactive protein (hsCRP), albumin, insulin-like growth factor 1 (IGF-1), IGF binding protein 1 (IGFBP-1) and ghrelin], measurements of body weight and assessment of oral mucositis.. RESULTS: The mean nadir of weight loss was observed at the end of RT. At the time of diagnosis, mean hsCRP was 5.2 ± 1.0 mg/L. HsCRP significantly increased during RT and decreased during the post-RT period. Mean maximum hsCRP was 35.8 ± 8.5 mg/L, with seven patients reaching ,40 mg/L. A numerical decrease of albumin (by 18.2%) and only small changes in IGF-1, IGFBP-1 and ghrelin levels were observed. None of the metabolic parameters was significantly associated with weight loss.. CONCLUSIONS: HsCRP increased in response to RT for H&N ...
One of the reasons inflammation occurs is from a rapid rise in blood sugar, which causes biochemical changes in the cell. Staying away from sugar and high-glycemic (simple) carbohydrates, which the body rapidly converts to sugar, is one of the best ways to decrease inflammation. C-reactive protein (CRP) is a key factor of inflammation. In a major study, published in the New England Journal of Medicine, people with elevated CRP levels were four and one-half times more likely to have a heart attack. Not only is elevated CRP more accurate than cholesterol in predicting heart attack risk, but high CRP levels have turned up in people with diabetes and pre-diabetes and in people who are overweight. [58, 59,61] ...
By now, most everybody who is paying attention knows that uncontrolled and/or excessive inflammation is damaging to the body and leads to chronic disease. One good way to measure the inflammation in your body is with an inexpensive and very common blood test called the hs-CRP (highly sensitive C-reactive protein). The normal range for hs-CRP is less than 3 mg/L. But the healthiest level of inflammation yields an hs-CRP less than 1 mg/L. So please have your doctor check this test at least once a year. And if its consistently more than 1 mg/L, its in your best interest to do something to bring it down. Heres what you can do ...
Human C-reactive protein is an acute phase protein whose blood concentrations rise dramatically in response to inflammatory insults. Though CRP is primarily of...
A COMPARATIVE STUDY OF INFLAMMATORY MARKER HIGHLY SENSITIVE C-REACTIVE PROTEIN BETWEEN DEPRESSION PATIENTS WITH SUICIDAL ATTEMPT AND DEPRESSION PATIENTS WITH SUICIDAL ...
J.Nutr.Biochem., 2011, IF: 4.538, PMID: 21889886. Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFalpha)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic ...
This project examines longitudinal associations between serum C-reactive protein (CRP) levels, measured using a high-sensitivity assay, and established cardiovascular risk factors such as blood pressure and lipid levels, as well as resting heart rate, waist/hip ratio and daily hours of sleep. Unexpected negative associations were found with total cholesterol and triglyceride levels, contrary to what was expected. A significant positive association, not explained by physical activity or infection status, was found with resting heart rate. Further study is warranted.
Sounds like a bunch of CRP And I wish it was. Hi, I am Yountville Xocai blogger Pol vanRhee. Todays post explores the link between CRP levels, inflammation and heart disease. So, what is CRP? CRP is a measure of C-reactive protein in the blood. You can get your CRP tested when you get your […]. ...
BACKGROUND:. There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.. METHODS:. We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. We calculated measures of discrimination and reclassification during follow-up and modeled the clinical implications of initiation of statin therapy after the assessment of CRP or fibrinogen.. RESULTS:. The addition of information on high-density lipoprotein cholesterol to a prognostic model for cardiovascular disease that included age, sex, smoking status, blood pressure, history of diabetes, and total cholesterol level increased the C-index, a measure of risk discrimination, by 0.0050. The further addition to this model of information on CRP or ...
Comparative assessmentof bloodprocalcitonin and C-reactive protein determination methods in community-acquired pneumonia has been performed. Practical advantage of C-reactive protein determination...
The C-reactive protein test is a highly sensitive test for the presence of acute inflammation. The capsule of the pneumococcus bacterium contains a specific polysaccharide called C polysaccharide, which behaves as a specific antigen. If one studies the sera of patients with pneumonitis of pneumococcal origin, an antibody for this C polysaccharide can be demonstrated. The antibody is a protein and has been named C-reactive protein.. In 1930 Tillet and Francis1 demonstrated for the first time the presence of the above substance in a patient with pneumococcal pneumonitis. Later they observed that this substance was found only in sera of ...
We assessed whether C-reactive protein (CRP) concentrations predicted future risk of hypertension in a cohort of young adults. Results showed that CRP levels do not independently predict risk of incident hypertension after accounting for body mass index. Further research is needed in the area of inflammation and hypertension, with a special focus on the effect of obesity and age-related changes on this process.
Feeling C-REACTIVE PROTEIN INCREASED while using Penicillin? C-REACTIVE PROTEIN INCREASED Causes, Patient Concerns and Latest Treatments and Penicillin Reports and Side Effects.
Researchers claim to have found that C-reactive protein is not merely a marker of the risk of hypertension, it actually induces hypertension. Using a mouse model having an engineered gene for CRP that was regulated by another gene responsive to carbohydrate in the diet, the researchers determined that raising CRP levels increased blood pressure, while lowering CRP levels lowered blood pressure. (It has been known for some time that high CRP levels are correlated with risk of hypertension and atherosclerosis.) Further investigation showed that the experimental mice were highly sensitive to the blood pressure regulating protein angiotensin II, and this was due to alterations in key proteins in the vascular wall that are involved with angiotensin II. The mechanism involves a lack of nitric oxide in the artery wall, and a connection was found between nitric oxide and proteins responsible for angiotensin II activity. Remaining to be shown is whether the same mechanism operates in humans ...
Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules. The remainder of the physical examination was unremarkable and without stigmata of Graves disease. Her initial blood tests revealed overt thyrotoxicosis, elevated liver enzymes, an elevated C-reactive protein, a negative monospot and a positive CMV IgM antibody. Thyroid sonography revealed areas of hypoechogenicity and relatively low vascularity. Fine-needle biopsy showed a lymphocytic infiltrate. The patient ...
Compared to placebo, canakinumab had modest but nonsignificant effects on glycated hemoglobin (HbA1c, glucose, and insulin levels. No effects were seen for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or non-HDL-C, although triglyceride levels increased approximately 10% in the 50 (p = 0.02) and 150 (p = 0.03) mg groups. Median reductions in C-reactive protein at 4 months were 36.4%, 53.0 %, 64.6%, and 58.7% for the 5, 15, 50, and 150 mg canakinumab doses, respectively, compared to 4.7% for placebo (all p values ≤ 0.02). Similarly, the median reductions in IL-6 at 4 months across the canakinumab dose range tested were 23.9%, 32.5%, 47.9%, and 44.5%, respectively, compared to 2.9% for placebo (all p ≤ 0.008), and the median reductions in fibrinogen at 4 months were 4.9%, 11.7%, 18.5%, and 14.8%, respectively, compared to 0.4% for placebo (all p values ≤ 0.0001). Adverse events were similar in the canakinumab and placebo groups.. ...
OBJECTIVES: In order to standardize the CRP, ESR and WBC count after three types of spinal surgery and get clinical usefulness from these laboratory dadas after spinal surgery and clincal usefulness of laboratory datas. MATERIAL AND METHODS: Three groups of patients(microdisectomy, anterior and posterior fusion) were chosen for the study. CRP, ESR and WBC levels were prospectively determined before surgery and at days 1-5, 10, 14,21 and 42 after surgery. RESULTS: In all patients, preoperative normal CRP level ...
C-reactive protein, an indicator of acute inflammation, is the subject of considerable controversy as an important biomarker of cardiovascular health.. It is important to recognize that CRP levels are not specific to any area of inflammation and that there are many conditions that may cause inflammation and stimulate elevation of circulating CRP several times that above normal. There are also numerous non-inflammatory processes that cause local release and systemic exposure to inflammatory mediators, such as CRP.. CRP is produced by the liver and vascular endothelial cells, such those that line the arterial walls of major blood vessels of the heart and other vital organs. This protein is produced whenever an inflammatory process is initiated in the body and under normal physiological conditions, such as everyday stress, pregnancy, and aging.. Many clinical conditions contribute to the elevation of CRP. The classic work by Gabay and Kushner (1999) has enhanced our understanding of the role of CRP ...
Results We identified five dietary patterns: healthy (high in vegetables and fruit), Western (high in meat and fried foods), seafood (high in shellfish, squid, fish, etc), bread (high in bread and low in rice), and dessert (high in confections and fruit). After adjustment for age, alcohol use, smoking, physical activity, and body mass index, hs-CRP levels in men were inversely associated with the healthy, bread, and dessert patterns (p-trend: 0.02, 0.06, and 0.001, respectively) and positively associated with the seafood pattern (p-trend=0.03). In women, hs-CRP levels were inversely associated with the healthy pattern (p-trend=0.07) and positively associated with the Western pattern (p-trend=0.06). ...
What is c reactive protein (CRP) and what does it mean? How is a high CRP level associated with both getting colon cancer and dying from it?
IMPORTANCE: Longitudinal studies have linked the systemic inflammatory markers interleukin 6 (IL-6) and C-reactive protein (CRP) with the risk of developing heart disease and diabetes mellitus, which are common comorbidities for depression and psychosis. Recent meta-analyses of cross-sectional studies have reported increased serum levels of these inflammatory markers in depression, first-episode psychosis, and acute psychotic relapse; however, the direction of the association has been unclear. OBJECTIVE: To test the hypothesis that higher serum levels of IL-6 and CRP in childhood would increase future risks for depression and psychosis. DESIGN, SETTING, AND PARTICIPANTS: The Avon Longitudinal Study of Parents and Children (ALSPAC)is a prospective general population birth cohort study based in Avon County, England. We have studied a subsample of approximately 4500 individuals from the cohort with data on childhood IL-6 and CRP levels and later psychiatric assessments. MEASUREMENT OF EXPOSURE: ...
C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein that exhibits elevated expression during inflammation. CRP can be found in its pentameric form (nCRP) or monomeric form (mCRP). To date there has been little research investigating the effects of these CRP isoforms in wound healing processes and age-related impaired healing, which is known to have an altered inflammatory response. The study investigated CRP isoform localisation in murine wounds (detected by immunohistochemistry) and circulating blood (measured by immunoblotting) using models of acute healing in young adults and age-related impaired healing (n=3). Using in vitro inflammatory cell assays developed with the monocytic U937 cell line this study investigated the effects of CRP isoforms in nitric oxide release (detected by an immunoassay), phagocytosis (measured by a bacterial recovery assay), apoptosis (detected via DNA fragmentation) and cytokine secretion (measured by a multiplex immunoassay) in both ...
Vitamin D, Calcium & Phosphorus. Vitamin D is essential for strong bones, because it helps the body use calcium from the diet. Traditionally, vitamin D deficiency has been associated with rickets, a disease in which the bone tissue doesnt properly mineralize, leading to soft bones and skeletal deformities.. . Glucose Fasting ( Sugar ). A blood glucose test measures the amount of a Sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including brain cells.. . Rheumatoid arthritis. Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.. . C-reactive protein (CRP). A high level of CRP in the blood is a marker of any condition that causes inflammation, from an upper respiratory infection to cancer. High CRP levels can indicate that there is inflammation in the ...
Vitamin D, Calcium & Phosphorus. Vitamin D is essential for strong bones, because it helps the body use calcium from the diet. Traditionally, vitamin D deficiency has been associated with rickets, a disease in which the bone tissue doesnt properly mineralize, leading to soft bones and skeletal deformities.. . Glucose Fasting ( Sugar ). A blood glucose test measures the amount of a Sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including brain cells.. . Rheumatoid arthritis. Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.. . C-reactive protein (CRP). A high level of CRP in the blood is a marker of any condition that causes inflammation, from an upper respiratory infection to cancer. High CRP levels can indicate that there is inflammation in the ...
Background: Factors determining in-hospital mortality of patients ventilated with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are not precisely understood.. PURPOSE: The aim of this study was to assess the correlation between acute phase proteins [High sensitivity C-reactive protein (CRP) and prealbumin (PA)] and mortality in ventilated patients with COPD.. METHODS: We evaluated 336 COPD patients with AECOPD and on invasive mechanical ventilation. Detailed clinical evaluation was done daily. Concentration of CRP and PA was measured on admission, 3rd, 8th and 16th day.. RESULTS: During the study; 237 patients were discharged and 99 died. The difference between the two groups in CRP and PA was significant at admission, 3rd, 8th day and 16th day. In non survivors; there was a significant increase in CRP values with a significant decrease in PA with time (P,0.001). In-hospital mortality was significantly associated with lower arterial oxygen tension, higher carbon dioxide ...
Objective. To examine whether the determination of interleukin 8 IL-8 and C-reactive protein CRP in neonates with suspected nosocomial bacterial infection NBI is feasible and cost-effective in reducing antibiotic therapy. Methods. Between April 1996 and May 1997, IL-8 was measured 260 times along with blood cultures, CRP, and immature-to-total-...
INTRODUCTION: The efficacy of statin treatment in chronic kidney disease (CKD) patients remains controversial. Therefore, we performed a meta-analysis to investigate whether statins modulate renal function in patients with CKD. METHODS: Data from Scopus, PubMed, Web of Science, and the Cochrane Central Register of randomized controlled trials for years 1966-December 2012 were searched for appropriate studies. RESULTS: Twenty trials with 6452 CKD subjects randomized to receive either statin or placebo were included. Statin therapy significantly influenced high sensitivity C-reactive protein levels in patients on or off dialysis [-0.28 mg/dl, 95%CI: -0.93 to -0.37; p,0.05 and -0.46 mg/dl, 95%CI: -0.87 to -0.05; p=0.03], respectively], urinary protein (-0.77 g/24 h, 95%CI: -1.24 to -0.29, p,0.02; this effect persisted for treatment ≤12 months), and serum creatinine but only for long-term therapy (3 years) (-0.65 mg/dl, 95%CI: -1.00 to -0.30; p=0.0003). The summary for standardized effect size of ...
The maternal secondary outcome measurements are outlined in Figure 2 and described more in detail below.. Blood sampling for fasting glucose concentrations and the other blood markers will be taken after a 10 hour overnight fast, and glucose tolerance will be measured by a 2 hour 75 mg per-oral glucose tolerance test. Gestational diabetes is diagnosed as fasting glucose ≥ 6.9 mmol/L or 2 h concentration ≥ 7.8 mmol/L [22]. Insulin resistance will be calculated using the homeostasis model assessment (HOMA-IR). We will analyse fasting blood for concentrations of lipids, ferritin, haemoglobin, high-sensitive C-reactive protein, and insulin c-peptide. We will also collect whole blood and serum to be frozen at -80C and stored in a biobank for later analyses of hormones associated with female reproduction and blood markers associated with adiposity and insulin resistance. We will also collect Tempus blood RNA tubes and urinarysamples to be frozen for later analyses.. Body height will be measured by ...
As you will notice, the link above does not take family history of disease into consideration. A different risk calculator, linked here, estimates a risk score called the Reynold Risk Score. It takes hsCRP (high sensitivity C-reactive protein, an inflammation marker) and family history in addition to the Framingham parameters in its risk score calculation ...
Hs-CRP levels are elevated in the metabolic syndrome likely mediated from inflammatory cytokines in visceral fat, correlate with number and severity of the criteria, predict vascular event risk, and may have a role in the development of diabetes. Recent studies confirm the predictive value of hs-CRP for cardiovascular (CV) events, but do not support a causal role in the disease expression ...
C Reactive Protein is a measurement of CRP by a high sensitivity assay, hs-CRP, allows for a lower detection limit related to chronic, low grade inflammation which is associated with heart disease. High Sensitivity C Reactive Protein may add to the predicative value of other markers used to assess a patients risk of heart and peripheral vascular disease. Purchase on our secure website. Lab order is provided by us. You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab. You receive the results by email within 2-3 weeks. Got insurance? Some tests are covered. Call
Results: MetS patients from the entire group of 47 patients were divided into four cohorts depending on 25(OH)D3 levels. The groups comprised patients with 25(OH)D3 levels above 100 nmol/L (n = 10), patients with levels from 50 to 100 nmol/L (n = 12), patients with levels from 30 to 50 nmol/L (n = 14), and patients with levels below 30 nmol/L (n = 11). There were significant differences between the MetS cohorts in terms of haemoglobin A1c (HbA1c) (P = 0.038), the homeostasis model assessment for insulin resistance (HOMA-IR) (P = 0.042), triglycerides (P = 0.044), osteoprotegerin (P=0.028), adiponectin (P = 0.018), high density lipoprotein cholesterol (HDL-C) (P=0.036), and CD14+СD309+Tie-2+ cells. Vitamin D deficiency in a multivariate log-linear regression model appeared to be an independent predictor of the numbers of CD14+СD309+ Tie-2+ cells (OR 1.12; 95% CI 1.06 to 1.19; P = 0.002). Osteoprotegerin, high sensitivity C-reactive protein (hs-CRP), and adiponectin have been shown to make an ...
getting negative protein measurements - posted in SDS-PAGE and Western Blotting: Hello, Ive been having some trouble with my cell lysates in preparation for a western. I collected my cells using RIPA buffer but after spinning them down to get rid of the nucleus, no pellet seems to show up. Weve had problems with our RIPA buffer before and finally got it fixed and this is the first time for me to use it ever since. I went ahead and did the protein measurements using Bio-Rad assa...
Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.. Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.. Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.. Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.. Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein ...
TY - JOUR. T1 - Left Ventricular Diastolic Dysfunction in Peritoneal Dialysis. AU - Wu, Cho Kai. AU - Lee, Jen Kuang. AU - Wu, Yi Fan. AU - Tsai, Chia Ti. AU - Chiang, Fu Tien. AU - Hwang, Juey Jen. AU - Lin, Jiunn Lee. AU - Hung, Kuan Yu. AU - Huang, Jenq Wen. AU - Lin, Jou Wei. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Left ventricular diastolic dysfunction (LVDD) is common among patients undergoing peritoneal dialysis (PD). We examined the relationship between LVDD, major adverse cardiovascular events (MACE), and mortality in PD patients. A total of 149 patients undergoing PD with preserved left ventricular systolic function were included and followed for 3.5 years. LVDD was diagnosed (according to the European Society of Cardiology guidelines) by conventional and tissue Doppler echocardiography. Serum high-sensitivity C-reactive protein (hsCRP) was measured. The location and volume of adipose tissue were assessed by computed tomography (CT) at the level of the fourth lumbar vertebra. Subjects with ...
Looking for online definition of acute phase reaction in the Medical Dictionary? acute phase reaction explanation free. What is acute phase reaction? Meaning of acute phase reaction medical term. What does acute phase reaction mean?
BACKGROUND: Inflammatory and proteolytic activity occurs in sputum from patients with stable purulent bronchiectasis and has been proposed as the main pathogenetic mechanism of the disease. This study was designed to define further the role of inflammation and proteolysis in bronchiectasis. METHODS: Neutrophil elastase activity, sputum concentrations of the serum derived inhibitors alpha 1 antiproteinase and alpha 2 macroglobulin, and the sputum to serum ratios of albumin and C reactive protein concentration were measured in 26 patients with bronchiectasis. RESULTS: Free elastase activity was found in 15 sputum samples. A trend to higher proteolytic and inflammatory activity was found between mucoid and purulent sputum samples, suggesting that inflammatory and proteolytic activities are related to the macroscopic degree of purulence. Purulent sputum had a high sputum to serum ratio of C reactive protein, suggesting local production or active transport of this protein into bronchial secretions. C ...
TY - JOUR. T1 - Persistent fever and destructive arthritis caused by dialysis-related amyloidosis. AU - Matsumoto, Kotaro. AU - Kikuchi, Jun. AU - Kaneko, Yuko. AU - Yasuoka, Hidekata. AU - Suzuki, Kazuko. AU - Tokuyama, Hirobumi. AU - Kameyama, Kaori. AU - Yamaoka, Kunihiro. AU - Takeuchi, Tsutomu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Rationale: Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes. Patient concerns: A 64-year-old man on hemodialysis for ,30 years was admitted because of intermittent fever, polyarthritis, and elevated serum C-reactive protein (CRP) level, which was continuous for 2 years. Several antibiotics were ineffective for 3 months before his admission. On physical examination, joint swelling was observed at bilateral wrists, knees, ...
Looking for online definition of Acute phase reactant in the Medical Dictionary? Acute phase reactant explanation free. What is Acute phase reactant? Meaning of Acute phase reactant medical term. What does Acute phase reactant mean?
ANA (Antinuclear Antibody) measurement Anti-cyclic citrullinated peptide antibody level Erythrocyte sedimentation rate measurement Rheumatoid factor measurement Serum C reactive protein level Serum uric acid measurement Medical Tests Analyzer labtest bloodtest What does the test result mean?
OBJECTIVE: To evaluate glucocorticoid doses and serological findings in patients with giant cell arteritis (GCA) flares.. METHODS: Patients with GCA were randomly assigned to receive double-blind dosing with subcutaneous tocilizumab (TCZ) 162 mg weekly plus 26-week prednisone (TCZ-QW+Pred-26), every-other-week TCZ plus 26-week prednisone (TCZ-Q2W+Pred-26), placebo plus 26-week prednisone (PBO+Pred-26), or placebo plus 52-week prednisone (PBO+Pred-52). Outcomes were prednisone dose, C-reactive protein (CRP) level, and erythrocyte sedimentation rate (ESR) at the time of flare and remission during 52 weeks.. RESULTS: One hundred patients received TCZ-QW+Pred-26, 49 received TCZ-Q2W+Pred-26, 50 received PBO+Pred-26, and 51 received PBO+Pred-52. Among 149 TCZ-treated patients, 36 (24%) experienced flare, 23 (64%) of whom were still receiving prednisone (median dose, 2.0 mg/day). Among 101 PBO+Pred-treated patients, 59 (58%) experienced flare, 45 (76%) of whom were receiving prednisone (median dose, ...
TY - JOUR. T1 - Plasma cytokines eotaxin, MIP-1α, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection. AU - Relster, Mette Marie. AU - Holm, Anette. AU - Pedersen, Court. N1 - © 2016 APMIS. Published by John Wiley & Sons Ltd.. PY - 2017. Y1 - 2017. N2 - Major overlaps of clinical characteristics and the limitations of conventional diagnostic tests render the initial diagnosis and clinical management of pulmonary disorders difficult. In this pilot study, we analyzed the predictive value of eotaxin, macrophage inflammatory protein 1 alpha (MIP-1α), monocyte chemoattractant protein 4 (MCP-4), and vascular endothelial growth factor (VEGF) in 40 patients hospitalized with acute lower respiratory tract infections (LRTI). The cytokines contribute to the pathogenesis of several inflammatory respiratory diseases, indicating a potential as markers for LRTI. Patients were stratified according to etiology and severity of LRTI, based on baseline C-reactive protein and ...

C-Reactive Protein | SpringerLinkC-Reactive Protein | SpringerLink

High-sensitivity C-reactive protein; hs-CRP; Pentaxin; Pentraxin 1; PTX1 Tillett and Francis (1930) noticed that C ... C-Reactive protein in human atherogenesis: facts and fiction, C-reactive protein in human atherogenesis: facts and fiction. ... Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein ... The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in ...
more infohttps://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101542

C-reactive Protein | Care2 Healthy LivingC-reactive Protein | Care2 Healthy Living

Our Promise: Welcome to Care2, the worlds largest community for good. Here, youll find over 45 million like-minded people working towards progress, kindness, and lasting impact.. Care2 Stands Against: bigots, bullies, science deniers, misogynists, gun lobbyists, xenophobes, the willfully ignorant, animal abusers, frackers, and other mean people. If you find yourself aligning with any of those folks, you can move along, nothing to see here.. Care2 Stands With: humanitarians, animal lovers, feminists, rabble-rousers, nature-buffs, creatives, the naturally curious, and people who really love to do the right thing ...
more infohttps://www.care2.com/greenliving/tag/c-reactive-protein

C-Reactive Protein AssayC-Reactive Protein Assay

... ,Solid phase capture sandwich ELISA assay using a microwell format.,medicine,medical supply,medical ... C-Reactive Protein (CRP) Assay. 3. C-Reactive Protein - Rapid Test. 4. Immunex CRP® C-Reactive Protein. 5. C-Reactive Protein. ... C-Reactive Protein, High Sensitivity. 7. C-Reactive Protein, Neonatal. 8. Total Protein. 9. Total Protein Reagent. 10. Total ... Protein Reagent Set. 11. Proteomelab™ XL-A/XL-I Protein Characterization System. ...
more infohttp://www.bio-medicine.org/medicine-products/C-Reactive-Protein-Assay-11761-1/

C-reactive protein: MedlinePlus Medical EncyclopediaC-reactive protein: MedlinePlus Medical Encyclopedia

It is one of a group of proteins called acute phase reactants that go up in response ... C-reactive protein (CRP) is produced by the liver. The level of CRP rises when there is inflammation throughout the body. ... C-reactive protein (CRP) is produced by the liver. The level of CRP rises when there is inflammation throughout the body. It is ... A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a persons ...
more infohttps://medlineplus.gov/ency/article/003356.htm

C-Reactive ProteinC-Reactive Protein

... , C Reactive Protein, CRP, C-RP, High-Sensitivity CRP, hs-CRP. ... C-reactive protein, C-Reactive Protein, Protein, C-Reactive, C Reactive Protein, Proteins, specific or class, C-reactive, C- ... c reactive protein, c-reactive protein (CRP), CRP, c reactive proteins, Pentraxin 1, Short, Pentraxin 1, C reactive protein, ... C-Reactive Protein Aka: C-Reactive Protein, C Reactive Protein, CRP, C-RP, High-Sensitivity CRP, hs-CRP ...
more infohttps://fpnotebook.com/HemeOnc/Lab/CRctvPrtn.htm

C-reactive protein definition | Drugs.comC-reactive protein definition | Drugs.com

Definition of C-reactive protein. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... C-reactive protein. Definition: a ß-globulin found in the serum of various people with certain inflammatory, degenerative, and ... neoplastic diseases; although the protein is not a specific antibody, it precipitates in vitro the C polysaccharide present in ...
more infohttps://www.drugs.com/dict/c-reactive-protein.html

C-reactive protein - Heart Disease - MedHelpC-reactive protein - Heart Disease - MedHelp

C-reactive protein labrat Dear Doctor, In regards to the previous CRP question, I have another question. My CRP put me in the ... CRP (C-reactive protein) is not a cardio-specific marker but only a general marker of inflammation. We do know that the higher ... I also have a c-reactive protein level that puts me at high risk - 10.7. The test was repeated and came back at 10.3. My ...
more infohttps://www.medhelp.org/posts/Heart-Disease/C-reactive-protein/show/252215

C-Reactive ProteinC-Reactive Protein

... and homocysteine were measured in baseline and 6-month serum samples. HRT increased C-reactive protein ... C-reactive protein levels and their prognostic value in men compared with women. We also assessed whether C-reactive protein ... BACKGROUND: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, ... Association of C-reactive protein with markers of prevalent atherosclerotic disease.. Folsom AR, Pankow JS, Tracy RP, Arnett DK ...
more infohttp://www.thedoctorsdoctor.com/labtests/crp.htm

Fever, C-reactive protein… - Göteborgs universitet 
							
							
						
					
				
			Fever, C-reactive protein… - Göteborgs universitet

Acute-Phase Proteins, metabolism, C-Reactive Protein, metabolism, Endocarditis, Bacterial, blood, complications, drug therapy, ... Fever, C-reactive protein, and other acute-phase reactants during treatment of infective endocarditis.. Artikel i vetenskaplig ... Elevations in C-reactive protein levels were significantly prolonged in the episodes with complicated courses compared with the ... Fever and results of serial measurements of C-reactive protein, erythrocyte sedimentation rate, white blood cell counts, and ...
more infohttps://gu.se/forskning/publikation/?publicationId=285415

JCI -
C-reactive protein: a critical updateJCI - C-reactive protein: a critical update

Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein ... C-reactive protein: a critical update. Mark B. Pepys and Gideon M. Hirschfield Centre for Amyloidosis and Acute Phase Proteins ... Phylogenetic aspects of C-reactive protein and related proteins. Ann. N. Y. Acad. Sci. 1982. 389:49-75. View this article via: ... The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N. Engl. J. Med. 1994. 331: ...
more infohttps://www.jci.org/articles/view/18921

C reactive protein blood test - Shannon79s Journal - MedHelpC reactive protein blood test - Shannon79's Journal - MedHelp

C reactive protein blood test Nov 19, 2018 - 2 comments Yes its been a long time since Ive posted anything let alone a ... And the C Reactive Protein was just slightly elevated. But to me, that tells me theres inflammation in my body. Nope shes not ... And it could just be from getting older. I actually had to do my own research to see what the C Reactive Protein test was. The ... Personally, I had a whole slew of labs done with C reactive protein being one of them that was elevated (not near normal at all ...
more infohttps://www.medhelp.org/user_journals/show/2323131/C-reactive-protein-blood-test

C-reactive protein | Occupational & Environmental MedicineC-reactive protein | Occupational & Environmental Medicine

You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our cookies policy. ...
more infohttps://oem.bmj.com/keyword/c-reactive-protein

High-Sensitivity C-Reactive Protein | HealthLink BCHigh-Sensitivity C-Reactive Protein | HealthLink BC

The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that looks at the lower levels of C-reactive protein (CRP ... The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that finds lower levels of C-reactive protein (CRP). This ... The standard test measures high levels of the protein to find different diseases that cause inflammation. The hs-CRP test ... protein measures general levels of inflammation in your body. The hs-CRP can be used to find the risk for heart disease and ...
more infohttps://www.healthlinkbc.ca/medical-tests/abq4481

Blood Test: C-Reactive Protein (CRP)Blood Test: C-Reactive Protein (CRP)

... What It Is. A C-reactive protein (CRP) blood test is used to identify inflammation or ... C-reactive protein is released into the blood by the liver shortly after the start of an infection or inflammation. CRP is an ... The C-reactive protein test is considered a safe procedure. However, as with many medical tests, some problems can occur with ... Doctors may order the C-reactive protein test if symptoms suggest any kind of inflammation, particularly related to ...
more infohttps://www.rchsd.org/health-articles/blood-test-c-reactive-protein-crp/

C-reactive protein in cardiovascular diseases].  - PubMed - NCBIC-reactive protein in cardiovascular diseases]. - PubMed - NCBI

C-reactive protein ranked as an acute phase protein, produced by the liver as an answer to cytokine stimulation is an ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=17203810

C-reactive protein - wikidocC-reactive protein - wikidoc

MedlinePlus Encyclopedia C-reactive protein. *Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein (American ... C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response ... "Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares ... or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.[4] ...
more infohttps://www.wikidoc.org/index.php/C-reactive_protein

C-Reactive Protein - Updated InfoC-Reactive Protein - Updated Info

Re: C-Reactive Protein - Updated Info by Dr. Neal Pinckney on 6/02/10 (. 0) Name: E-mail: (optional). Subject: Comments:. ... Performed a comprehensive search om the board and found the latest discussions about C-Reactive Protein dated from 2005.. Has ...
more infohttps://vegsource.com/talk/healingheart/messages/1212952.html

How to Lower CRP (C‐Reactive Protein) (with Pictures) - wikiHowHow to Lower CRP (C‐Reactive Protein) (with Pictures) - wikiHow

C-reactive protein) is a natural substance produced by the liver. Increased amounts of CRP generally lead to increased ... CRP (C-reactive protein) is a natural substance produced by the liver. Increased amounts of CRP generally lead to increased ... How to Lower CRP (C‐Reactive Protein). Author Info , Reader-Approved Updated: March 29, 2019 ... www.pritikin.com/your-health/health-benefits/lower-cholesterol/811-which-diet-lowers-c-reactive-protein.html#.VRBMBfnF8_J ...
more infohttps://www.wikihow.com/Lower-CRP-

C-Reactive Protein May Predict Brain Changes | Medpage TodayC-Reactive Protein May Predict Brain Changes | Medpage Today

Elevated levels of high-sensitivity C-reactive protein (CRP) are associated with cognitive impairment and white matter damage, ... Source Reference: Wersching H, et al "Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive ... Explain to interested patients that in this study, elevated levels of high-sensitivity C-reactive protein (CRP) were associated ... Elevated levels of high-sensitivity C-reactive protein (CRP) are associated with cognitive impairment and white matter damage, ...
more infohttps://www.medpagetoday.com/neurology/generalneurology/19279

Biology of C Reactive Protein in Health and Disease | SpringerLinkBiology of C Reactive Protein in Health and Disease | SpringerLink

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history ... This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history ...
more infohttps://link.springer.com/book/10.1007/978-81-322-2680-2

Elevated serum C-reactive protein... preview & related info | MendeleyElevated serum C-reactive protein... preview & related info | Mendeley

Elevated serum C-reactive protein and markers of sleep disordered breathing. *Wiener R ... The main outcome was a C-reactive protein (CRP) of ,1 mg/dL. Results. Snoring, snorting, daytime sleepiness, and sleeping ,7 or ... Wiener, R. C., Zhang, R., & Shankar, A. (2012). Elevated serum C-reactive protein and markers of sleep disordered breathing. ...
more infohttps://www.mendeley.com/catalogue/elevated-serum-creactive-protein-markers-sleep-disordered-breathing/

Cytokines and C-reactive protein producti... & related info | MendeleyCytokines and C-reactive protein producti... & related info | Mendeley

BACKGROUND The study aim was to determine the kinetics of serum pro- and anti-inflammatory cytokines and C-reactive protein ( ... Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. *Beloosesky Y ... BACKGROUND The study aim was to determine the kinetics of serum pro- and anti-inflammatory cytokines and C-reactive protein ( ...
more infohttps://www.mendeley.com/research-papers/cytokines-creactive-protein-production-hipfractureoperated-elderly-patients/

C-reactive protein - 
                    
                        ChemgapediaC-reactive protein - Chemgapedia

C-reactive proteinZoomA-Z. Subject - Biochemistry, Immunology. C-reactive protein (CRP); an acute-phase protein, serves as a ...
more infohttp://www.chemgapedia.de/vsengine/glossary/en/c_00045reactive_00032protein.glos.html

Is C-Reactive Protein a Valid Biomarker? - IFT.orgIs C-Reactive Protein a Valid Biomarker? - IFT.org

Is C-Reactive Protein a Valid Biomarker?. FOOD, MEDICINE & HEALTH. Food Technology Magazine , Article ... C-reactive protein elevation can be caused by conditions other than infl ammation and may refl ect biologic aging. Cleveland ... Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor ... C-reactive protein, an indicator of acute inflammation, is the subject of considerable controversy as an important biomarker of ...
more infohttps://www.ift.org/news-and-publications/food-technology-magazine/issues/2005/october/columns/food-medicine-and-health

Serum C-reactive protein … - University of Gothenburg, Sweden 
							
							
						
					
				
			Serum C-reactive protein … - University of Gothenburg, Sweden

Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Journal article ... BACKGROUND AND PURPOSE: C-reactive protein (CRP) has evolved as an inflammatory risk marker of cardiovascular disease. Several ... Adult, Aged, Brain Ischemia/*blood/complications/*genetics, C-Reactive Protein/*genetics/*metabolism, Case-Control Studies, ...
more infohttps://gu.se/english/research/publication/?publicationId=41572
  • Abernethy and Avery ( 1941 ) showed that serum taken from humans and monkeys contained protein that has the ability to precipitate with C polysaccharide during the acute stage of various infectious diseases, but in the presence of Ca 2+ . (springer.com)
  • The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. (springer.com)
  • although the protein is not a specific antibody, it precipitates in vitro the C polysaccharide present in all types of pneumococci. (drugs.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • The C-reactive protein is first synthesized as a 206 amino acid polypeptide, then secreted by the hepatocytes as a non-glycosylated monomer with a molar mass of 25106 daltons. (brighthub.com)
  • This protein is cleaved during biological activation and is associated with host defense mechanisms and inflammatory responses. (fpnotebook.com)
  • Immobilized p-Aminophenyl Phosphoryl Choline consists of a phosphoryl choline covalently linked to beaded agarose and is designed for the purification of C-reactive protein from plasma, ascites and other biological fluids. (gbiosciences.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • I also have a c-reactive protein level that puts me at high risk - 10.7. (medhelp.org)
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • In particular, the synthesis of a number of proteins is rapidly upregulated, principally in hepatocytes, under the control of cytokines originating at the site of pathology. (jci.org)
  • This makes the protein structure vulnerable to glycosylation from galactose, glucose, mannose or sialic acid. (brighthub.com)
  • OBJECTIVE: Several short-term trials on the effect of soy consumption on cardiovascular risks are available, but little evidence exists regarding the impact of long-term soy protein consumption among type 2 diabetic patients with nephropathy. (greenmedinfo.com)
  • To determine the effects of long-term soy consumption on cardiovascular risks, we measured C-reactive protein (CRP) and kidney function indexes among type 2 diabetic patients with nephropathy. (greenmedinfo.com)
  • Twenty patients in the soy protein group consumed a diet containing 0.8 g protein/kg body weight (35% animal proteins, 35% textured soy protein, and 30% vegetable proteins) and 21 patients in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins for 4 years. (greenmedinfo.com)
  • Accumulating evidence suggests that circulating high-sensitivity C-reactive protein (CRP) represents one of the strongest independent predictors of vascular death in a number of settings. (ahajournals.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The time frame of this occurs within 6 hours and protein number peaks to 50,000 at around 48 hours. (brighthub.com)
  • Address correspondence to: Mark B. Pepys, Department of Medicine, Centre for Amyloidosis and Acute Phase Proteins, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom. (jci.org)