An aspect of cholinesterase (EC 3.1.1.8).
A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
N,N',N'',N'''-Tetraisopropylpyrophosphamide. A specific inhibitor of pseudocholinesterases. It is commonly used experimentally to determine whether pseudo- or acetylcholinesterases are involved in an enzymatic process.
A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.
An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.
An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.
Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.
Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
An organophosphate cholinesterase inhibitor that is used as a pesticide.
An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.
Compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as CHOLINERGIC AGENTS and as INSECTICIDES.
An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.
An agent used as a substrate in assays for cholinesterases, especially to discriminate among enzyme types.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
The benzoic acid ester of choline.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Carbamate derivative used as an insecticide, acaricide, and nematocide.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
Phenyl esters of carbamic acid or of N-substituted carbamic acids. Structures are similar to PHENYLUREA COMPOUNDS with a carbamate in place of the urea.
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
A genus of the Torpedinidae family consisting of several species. Members of this family have powerful electric organs and are commonly called electric rays.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.
Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.
A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
The process of cleaving a chemical compound by the addition of a molecule of water.
Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.
Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.
A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.
The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.
Advanced technology that is costly, requires highly skilled personnel, and is unique in its particular application. Includes innovative, specialized medical/surgical procedures as well as advanced diagnostic and therapeutic equipment.
Facilities for the performance of services related to dental treatment but not done directly in the patient's mouth.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Individuals responsible for fabrication of dental appliances.

Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. (1/406)

Acetylcholinesterase (AChE) occurs in both asymmetric forms, covalently associated with a collagenous subunit called Q (ColQ), and globular forms that may be either soluble or membrane associated. At the skeletal neuromuscular junction, asymmetric AChE is anchored to the basal lamina of the synaptic cleft, where it hydrolyzes acetylcholine to terminate synaptic transmission. AChE has also been hypothesized to play developmental roles in the nervous system, and ColQ is also expressed in some AChE-poor tissues. To seek roles of ColQ and AChE at synapses and elsewhere, we generated ColQ-deficient mutant mice. ColQ-/- mice completely lacked asymmetric AChE in skeletal and cardiac muscles and brain; they also lacked asymmetric forms of the AChE homologue, butyrylcholinesterase. Thus, products of the ColQ gene are required for assembly of all detectable asymmetric AChE and butyrylcholinesterase. Surprisingly, globular AChE tetramers were also absent from neonatal ColQ-/- muscles, suggesting a role for the ColQ gene in assembly or stabilization of AChE forms that do not themselves contain a collagenous subunit. Histochemical, immunohistochemical, toxicological, and electrophysiological assays all indicated absence of AChE at ColQ-/- neuromuscular junctions. Nonetheless, neuromuscular function was initially robust, demonstrating that AChE and ColQ do not play obligatory roles in early phases of synaptogenesis. Moreover, because acute inhibition of synaptic AChE is fatal to normal animals, there must be compensatory mechanisms in the mutant that allow the synapse to function in the chronic absence of AChE. One structural mechanism appears to be a partial ensheathment of nerve terminals by Schwann cells. Compensation was incomplete, however, as animals lacking ColQ and synaptic AChE failed to thrive and most died before they reached maturity.  (+info)

The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase. (2/406)

Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and electric eel AcChE with apparent K(i)s of 415 and 194 nM, respectively. In contrast, human or equine butyryl-cholinesterase (BuChE) converted CPT-11 to SN-38 with K(m)s of 42.4 and 44.2 microM for the human and horse BuChE, respectively. Modeling of CPT-11 within the predicted active site of AcChE and BuChE corroborated experimental results indicating that, although the drug was oriented correctly for activation, the constraints dictated by the active site gorge were such that CPT-11 would be unlikely to be activated by AcChE.  (+info)

Cholinesterases in neural development: new findings and toxicologic implications. (3/406)

Developing animals are more sensitive than adults to acute cholinergic toxicity from anticholinesterases, including organophosphorus pesticides, when administered in a laboratory setting. It is also possible that these agents adversely affect the process of neural development itself, leading to permanent deficits in the architecture of the central and peripheral nervous systems. Recent observations indicate that organophosphorus exposure can affect DNA synthesis and cell survival in neonatal rat brain. New evidence that acetylcholinesterase may have a direct role in neuronal differentiation provides additional grounds for interest in the developmental toxicity of anticholinesterases. For example, correlative anatomic studies show that transient bursts of acetylcholinesterase expression often coincide with periods of axonal outgrowth in maturing avian, rodent, and primate brain. Some selective cholinesterase inhibitors effectively suppress neurite outgrowth in model systems like differentiating neuroblastoma cells and explanted sensory ganglia. When enzyme expression is altered by genetic engineering, acetylcholinesterase levels on the outer surface of transfected neurons correlate with ability to extend neurites. Certain of these "morphogenic" effects may depend on protein-protein interactions rather than catalytic acetylcholinesterase activity. Nonetheless, it remains possible that some pesticides interfere with important developmental functions of the cholinesterase enzyme family.  (+info)

Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. (4/406)

To confirm a synergistic effect between the polymorphic K variant of the butyrylcholinesterase (BChE-K) gene and the epsilon4 allele of the apolipoprotein E (APOE) gene in Alzheimer's disease, the frequency of the BChE-K allele was re-examined in a large series of Japanese patients with Alzheimer's disease and controls. Two hundred and three patients with Alzheimer's disease and 288 age and sex matched controls were genotyped by polymerase chain reaction and restriction fragment length polymorphism for BChE-K and APOE. No changes were found in the frequency of BChE-K, either in the Alzheimer's disease group as a whole (0.17 v 0.14; p=0.36) or in early (0.16 v 0.16; p=0.98) or late (0.17 v 0.13; p=0.24) onset patients compared with age matched controls. The study failed to confirm the findings of a previous study which found a significantly higher incidence of BChE-K in patients with Alzheimer's disease with APOE epsilon4 allele than in controls. In the Japanese population studied here, there was no association between BChE-K and Alzheimer's disease, nor an interaction between BChE-K and APOE epsilon4 allele.  (+info)

Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. (5/406)

AIM: To compare the anticholinesterase effects of huperzine A (Hup A), E2020, and tacrine in rats. METHODS: Spectrophotometry was used to determine AChE activity in brain and BuChE activity in serum. RESULTS: Following intragastric gavage, Hup A, E2020, and tacrine all produced dose-dependent inhibitions of brain AChE. Oral Hup A exhibited a higher inhibition than E2020 and tacrine. Tacrine was more effective in inhibiting serum BuChE correlated with severe peripheral adverse effects. The BuChE activity was less affected by Hup A and E2020. After a single oral dose of Hup A, a relatively steady state of AChE inhibition produced, which was longer than that after E2020 and tacrine. No change in the cholinesterase inhibition was seen for the 3 drugs following repeated i.g. medications. CONCLUSION: Hup A i.g. exhibited a higher efficacy, a longer duration of action, and a more selective inhibition on AChE than E2020 and tacrine.  (+info)

Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance. (6/406)

AIM: To compare the effects of synthetic and natural (-)-huperzine A (Hup A) on cholinesterase and mouse water maze performance. METHODS: Spectrophotometry was used to determine cholinesterase activity. Mouse water maze was used to evaluate nootropic effect. RESULTS: The IC50 of synthetic Hup A for acetylcholinesterase (AChE) of rat cortex and rat erythrocyte membrane determined in vitro were 64.7 (52.6-79.5) and 53.9 (43.6-66.6) nmol.L-1, respectively, and for butyrylcholinesterase of rat serum was 53.6 (44.9-63.8) mumol.L-1. Synthetic Hup A 0.12-0.48 mg.kg-1 ig produced a dose-dependent inhibition of brain AChE in mice. Synthetic Hup A 0.05 mg.kg-1 ig attenuated scopolamine-induced impairment of spatial memory. The efficacy of synthetic Hup A was the same as natural Hup A. CONCLUSION: Synthetic Hup A yielded an in vitro and in vivo pharmacological profile of activities similar to that of natural Hup A.  (+info)

Characteristics of recombinant human butyrylcholinesterase. (7/406)

AIM: To study the biochemical-pharmacological properties of the recombinant human butyrylcholinesterase (rhBChE) and thereby to size up the potential possibility of using it as a detoxifying agent in succinylcholine intoxication. METHODS: CHO-dhfr cells were transfected with plasmids by electroporation. BChE activity was determined colorimetrically by 5, 5'-dithiobis-(2-nitrobenzoic acid) (DTNB) method. Antigenicity was estimated by enzyme-linked immunosorbent assay and Western blot. RESULTS: The maximal expression amounted to 25.83 ng.h-1/10(6) cells. The rhBChE was highly similar to the native human BChE (nhBChE) in terms of its catalytic property, substrate affinity, inhibitor sensitivity, reactivation, stability, and immunoreactivity with anti-nhBChE antibodies. Mice challenged with 1.5 lethal dose of succinylcholine preincubated with rhBChE survived without any symptoms of intoxication. CONCLUSION: The rhBChE and nhBChE exhibit similar biochemical-pharmacological features. It is of potential value in practical use.  (+info)

Inhibitory effects of huperzine B on cholinesterase activity in mice. (8/406)

AIM: To determine the anticholinesterase properties of huperzine B (Hup B) and compare with tacrine in vitro and in vivo. METHODS: Spectrophotometry was used to determine ChE activity. RESULTS: Hup B showed much more selective inhibition to acetylcholinesterase (AChE) than tacrine. The IC50 ratios of Hup B and tacrine for butyrylcholinesterase (BuChE): AChE were 65.8 and 0.54, respectively. Hup B ig exhibited higher efficacy on the inhibition of brain AChE than that of tacrine. Tacrine was more effective in the inhibition of serum BuChE in mice with severe concomitant peripheral adverse effects than Hup B. A single ig dose of Hup B produced steady state of AChE inhibition in 4 h. CONCLUSION: Hup B exhibits higher selectivity and efficacy in the inhibition of AChE, and lower toxicity in mice than tacrine.  (+info)

The present study reports the effects of an ascorbic acid-deficient diet on liver and plasma butyrylcholinesterase activity. The activity of this enzyme decreased significantly in the plasma and liver subcellular fractions. The levels of plasma corticosterone were also significantly elevated in scurvy. The results are discussed in light of these observations ...
Butyrylcholinesterase (pseudocholinesterase) is a serine hydrolase synthesized in the liver and present in the plasma. It is structurally and functionally related to acetylcholinestrase, an enzyme that is that catalyzes the hydrolysis of acetylcholine. Butyrylcholinesterase catalyzes the hydrolysis of esters of choline, including acetylcholine, butyrylcholine, and succinylcholine, as well as the hydrolysis of esters such as cocaine, acetylsalicylic acid and heroin.. Succinylcholine is hydrolyzed to succinylmonocholine and choline. When succinylcholine is injected intravenously, about 90% of its dose is hydrolyzed by BChE within 1 min and only 10% reaches the neuromuscular junction. Because little or no butyrylcholinesterase is present at the neuromuscular junction, the neuromuscular blockade of succinylcholine is terminated by its diffusion away from the neuromuscular junction into the circulation. The effect of butyrylcholinesterase on onset and duration of action of succinylcholine is ...
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Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease. Shinohara, Mitsuru; Fujioka, Shinsuke; Murray, Melissa E.; Wojtas, Aleksandra; Baker, Matthew; Rovelet-Lecrux, Anne; Rademakers, Rosa; Das, Pritam; Parisi, Joseph E.; Graff-Radford, Neill R.; Petersen, Ronald C.; Dickson, Dennis W.; Bu, Guojun // Brain: A Journal of Neurology;May2014, Vol. 137 Issue 5, p1533 Sporadic and familial Alzheimer’s disease differ in region-specific amyloid-β accumulation, pattern of neurodegeneration, and symptoms. Shinohara et al. quantify amyloid-β, tau and related molecules and reveal a synapse-associated pattern of amyloid-β42 in sporadic disease, and... ...
Butyrylcholinesterase [BuChE (acylcholine acyl hydrolase); EC 3.1.1.8] limits the access of drugs, including tacrine, to other proteins. The atypical BuChE variant, in which Asp70 at the rim of the active site gorge is substituted by glycine, displayed a more drastically weakened interaction with tacrine than with cocaine, dibucaine, succinylcholine, BW284c51 [1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide], or alpha-solanine. To delineate the protein domains that are responsible for this phenomenon, we mutated residues within the rim of the active site gorge, the region parallel to the peripheral site in the homologous enzyme acetylcholinesterase [AChE (acetylcholine acetyl hydrolase); EC 3.1.1.7], the oxyanion hole, and the choline-binding site. When expressed in microinjected Xenopus laevis oocytes, all mutant DNAs yielded comparable amounts of immunoreactive protein products. Most mutants retained catalytic activity close to that of wild-type BuChE and were capable of binding ligands
This study sought to investigate the effect of infusions from green tea (|i|Camellia sinensis|/i|) and some citrus peels [shaddock (|i|Citrus maxima|/i|), grapefruit (|i|Citrus paradisi|/i|), and orange (|i|Citrus sinensis|/i|)] on key enzymes relevant to the management of neurodegenerative conditions [monoamine oxidase (MAO) and butyrylcholinesterase (BChE)]. The total phenol contents and antioxidant activities as typified by their 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals scavenging abilities, ferric reducing antioxidant properties, and Fe|sup|2+|/sup| chelating abilities were also investigated. Green tea had the highest total phenol (43.3 mg/g) and total flavonoid (16.4 mg/g) contents, when compared to orange [total phenol (19.6 mg/g), total flavonoid (6.5 mg/g)], shaddock [total phenol (16.3 mg/g), total flavonoid (5.2 mg/g)], and grapefruit [total phenol (17.7 mg/g), total flavonoid (5.9 mg/g)]. Orange (EC
The inhibition of horse serum butyrylcholinesterase (EC 3.1.1.8) by the organophosphorus compound paraoxon (diethyl 4-nitrophenyl phosphate) was studied by flow microcalorimetry at 37 degrees C in Tris buffer (pH 7.5) using a modification of the kinetic model described by Stojan and coworkers [J. Stojan, V. Marcel, S. Estrada-Mondaca, A. Klaebe, P. Masson, D. Fournier, A putative kinetic model for substrate metabolisation by Drosophila acetylcholinesterase, FEBS Lett. 440 (1998) 85-88]. The reversible steps of the inhibition were studied in the mixing cell of the calorimeter, whereas the irreversible step was studied in the flow-through cell. A new pseudo-first-order approximation was developed to allow the kinetic analysis of inhibition progress curves in the presence of substrate when a significant amount of substrate is transformed. This approximation also allowed one to compute an analytical expression of the calorimetric curves using a gamma distribution to describe the impulse response of the
TY - JOUR AU - Bosak, Anita AU - Opsenica, Dejan AU - Šinko, Goran AU - Zlatar, Matija AU - Kovarik, Zrinka PY - 2019 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2905 AB - Eight derivatives of 4-aminoquinolines differing in the substituents attached to the C(4)-amino group and C(7)were synthesised and tested as inhibitors of human acetylcholinesterase (AChE)and butyrylcholinesterase (BChE). Both enzymes were inhibited by all of the compounds with inhibition constants (K i )ranging from 0.50 to 50 μM exhibiting slight selectivity toward AChE over BChE. The most potent inhibitors of AChE were compounds with an n-octylamino chain or adamantyl group. The shortening of the chain length resulted in a decrease in AChE inhibition by 5-20 times. Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or π-interactions with ...
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators-pralidoxime, obidoxime and HI-6-which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.
Butyrylcholinesterase Genetic Variants: Association with Cocaine Dependence and Related Phenotypes. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
... ANNAPOLIS Md. April 9 2008 /- PharmAthen...Recent research conducted by Dr. Hermona Soreq and co-workers at theA... The role of amyloid plaques in the pathophysiology of Alzheimersdis...Recent in vitro data have demonstrated that rBChE effectively blocked...,PharmAthenes,Recombinant,Butyrylcholinesterase,(rBChE),May,Play,A,Neuroprotective,Role,in,Alzheimers,Disease,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
The pharmacological function of heroin requires an activation process that transforms heroin into 6-monoacetylmorphine (6-MAM), which is the most active form. The primary enzyme responsible for this activation process in human plasma is butyrylcholinesterase (BChE). The detailed reaction pathway of the activation process via BChE-catalyzed hydrolysis has been explored computationally, for the first time, in this study via molecular dynamics simulation and first-principles quantum mechanical/molecular mechanical free energy calculations. It has been demonstrated that the whole reaction process includes acylation and deacylation stages. The acylation consists of two reaction steps, i.e., the nucleophilic attack on the carbonyl carbon of the 3-acetyl group of heroin by the hydroxyl oxygen of the Ser198 side chain and the dissociation of 6-MAM. The deacylation also consists of two reaction steps, i.e., the nucleophilic attack on the carbonyl carbon of the acyl enzyme intermediate by a water molecule ...
Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identified the monoclonal antibodies that bind to overlapping and independent epitopes on human BChE. The nucleotide and amino acid sequences of 4 monoclonal antibodies are deposited in GenBank. Our goal was to determine which of the 5 monoclonal antibodies recognize BChE in the plasma of animals. Binding of monoclonal antibodies 11D8, B2 18-5, B2 12-1, mAb2 and 3E8 to BChE in animal plasma was measured using antibody immobilized on Pansorbin cells and on Dynabeads Protein G. A third method visualized binding by the shift of BChE activity bands on nondenaturing gels stained for BChE activity. Gels were counterstained for carboxylesterase activity. The three methods agreed that B2 18-5 and mAb2 have broad species specificity, but the other monoclonal antibodies interacted only with human BChE, the exception being ...
4B0P: A Step Toward the Reactivation of Aged Cholinesterases -Crystal Structure of Ligands Binding to Aged Human Butyrylcholinesterase
Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function. Several crystal structures of the former have shown that the active site is located at the bottom of a deep and narrow gorge, raising the question of how substrate and products enter and leave. Human butyrylcholinesterase (BChE) has attracted attention because it can hydrolyze toxic esters such as cocaine or scavenge organophosphorus pesticides and nerve agents. Here we report the crystal structures of several recombinant truncated human BChE complexes and conjugates and provide a description for mechanistically relevant non-productive substrate and product binding. As expected, the structure of BChE is similar to a previously published theoretical model of this enzyme and to the structure of Torpedo acetylcholinesterase. The main difference between the experimentally ...
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Organophosphorus nerve agents irreversibly inhibit cholinesterases. Phosphylation of the catalytic serine can be reversed by the mean of powerful nucleophiles like oximes. But the phosphyl adduct can undergo a rapid spontaneous reaction leading to an aged enzyme, i.e., a conjugated enzyme that is no longer reactivable by oximes. One strategy to regain reactivability is to alkylate the phosphylic adduct. Specific alkylating molecules were synthesized and the crystal structures of the complexes they form with soman-aged human butyrylcholinesterase were solved. Although the compounds bind in the active site gorge of the aged enzyme, the orientation of the alkylating function appears to be unsuitable for efficient alkylation of the phosphylic adduct. However, these crystal structures provide key information to design efficient alkylators of aged-butyrylcholinesterase and specific reactivators of butyrylcholinesterase. A step toward the reactivation of aged cholinesterases - Crystal structure of ...
Mouse Monoclonal Anti-Butyrylcholinesterase/BCHE Antibody (3E8) - BSA Free. Validated: ELISA. Tested Reactivity: Human. 100% Guaranteed.
Equipment for fast and accurate detection of organophosphate nerve agents is developed and tested. The method is based on the spectrophotometric monitoring of the enzyme activity of butyrylcholinesterase after its contact with air in a special absorption unit (a scrubber) developed for the purpose. The scrubber was made from a glass tube filled with glass beads (diam. 3 mm) and filled with approx. 5 ml of butyrylcholinesterase in a phosphate buffer of pH 7.4. The air sample was bubbled through this solution for 20 s at a flow rate of 80 l hour-1. Thereafter 8 microl of the enzyme solution were aspirated into the micro-SIA-LOV analyzer and the activity of the enzymes were evaluated by using Ellmans reagent, i.e. 2.5 mmol l-1 butyrylthiocholine iodide and 0.25 mmol 5,5-dithiobis (2-nitrobenzoic acid). The absorbance of the coloured reaction product was measured at 412 nm after the reaction time of 60 s. The residue of the absorption liquid was washed away from the absorber and the system was ...
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The military has endorsed a treatment protocol for possible nerve gas exposure that includes prophylactic PB at 30 mg/kg t.i.d. for 7 consecutive days. This treatment protocol is designed to produce 20% to 30% inhibition of plasma BuChE activity, a convenient index of AChE activity. We have attempted to devise a treatment regimen in rats that mimics some of the features of the military protocol. Delivery of PB at 0.018 mg/l in the drinking water produced 15% to 20% inhibition of BuChE activity in rats. Blood samples were obtained 2 h after the onset of the light phase. Inasmuch as rats drink approximately 80% of their water during the dark phase, it is likely that the levels of inhibition that we obtained represent steady-state rather than peak values. Moreover, rats exhibited some of the mild signs of cholinergic overstimulation, such as excessive lacrimation and diarrhea, signs also exhibited by troops during the PGW (Cook et al., 1992). However, drinking-related behaviors appeared to be ...
TY - JOUR. T1 - Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimers disease suggests choline acetyltransferase as a candidate deserving further study. AU - Cook, Lynnette J.. AU - Ho, Luk W.. AU - Wang, Lin. AU - Terrenoire, Edith. AU - Brayne, Carol. AU - Evans, John Grimley. AU - Xuereb, John. AU - Cairns, Nigel J.. AU - Turic, Dragana. AU - Hollingworth, Paul. AU - Moore, Pamela J.. AU - Jehu, Luke. AU - Archer, Nicola. AU - Walter, Sarah. AU - Foy, Catherine. AU - Edmondson, Amanda. AU - Powell, John. AU - Lovestone, Simon. AU - Williams, Julie. AU - Rubinsztein, David C.. PY - 2005/1/5. Y1 - 2005/1/5. N2 - Consistent deficits in the cholinergic system are evident in the brains of Alzheimers Disease (AD) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT), increased butyrylcholinesterase (BChE) activity, and a selective loss of nicotinic acetylcholine ...
4AXB: A Step Toward the Reactivation of Aged Cholinesterases -Crystal Structure of Ligands Binding to Aged Human Butyrylcholinesterase
HUP 13 is an analogue of huperzine A with comparable inhibitory action on acetylcholinesterase, but less inhibitory effect on butyrylcholinesterase. HUP 13 is
Background:Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimers disease (AD) risk, the results are still controversial. We thus conducted this meta-analysis. Material andMethods:We ...
OdreĎene su konstante brzine inhibicije dviju butirilkolinesteraza (BChE; EC 3.1.1.8) i dviju acetilkolinesteraza (AChE; EC 3.1.1.7) s racemičnim, (R)- i (S)- N,N-dimetilkarbamatom albuterola (4-(2-(tert-butilamino)-1-hidroksietil)-2-(hidroksimetil)fenol. Korištene su ljudska (hBChE) i BChE izolirana iz seruma konja (hoBChE), rekombinantna ljudska AChE (hAChE) i AChE izolirana iz električnog organa jegulje (eeAChE). Karbamat albuterola je progresivno inhibirao sve ispitivane kolinesteraze s konstantama brzine inhibicije reda veličine 103-106 dm3mol-1min-1, pri čemu je najbrţe inhibirao hBChE. Ispitivani karbamat se pokazao selektivnim inhibitorom koji hBChE inhibira 8 puta brţe od hAChE. TakoĎer, karbamat albuterola razlikuje kolinesteraze različitih vrsta, budući da hBChE inhibira 1,7 puta brţe od hoBChE, dok hAChE inhibira 34 puta brţe od eeAChE. Ljudske BChE i AChE su stereoselektivni enzimi koji imaju 13, odnosno 4 puta veći afinitet prema (R)-karbamatu albuterola. Inhibicijski ...
Foreword (Donald J. Ecobichon). Section I.. 1. Introduction (Tetsuo Satoh, Ramesh C. Gupta).. Section II: Metabolism and Mechanisms.. 2. ACETYLCHOLINESTERASE AND ACETYLCHOLINE RECEPTORS: BRAIN REGIONAL HETEROGENEITY (Haruo Kobayashi, Tadahiko Suzuki, Fumiaki Akahori and Tetsuo Satoh).. 3. GENOMIC IMPLICATIONS OF ANTICHOLINESTERASE SENSITIVITIES (Jonathan E. Cohen, Gabrial Zimmermann, Alon Friedman and Hermona Soreq).. 4. BUTYRYLCHOLINESTERASE: OVERVIEW, STRUCTURE AND FUNCTION (Oksana Lockridge, Ellen G. Duysen and Patrick Masson).. 5.CARBOXYLESTERASES:OVERVIEW, STRUCTURE, FUNCTION AND POLYMORPHISM (Masakiyo Hosokawa and Tetsuo Satoh).. 6. CARBOXYLESTERASES IN THE METABOLISM AND TOXICITY OF PESTICIDES (Colin J. Jackson, Juan Sanchez-Hernandez, Craig E. Wheelock and John G. Oakeshott).. 7. THE METABOLIC ACTIVATION AND DETOXICATION OF ANTICHOLINESTERASE INSECTICIDES (Janice E. Chambers, Edward C. Meek and Matthew Ross).. 8. PARAOXONASE 1: STRUCTURE, FUNCTION AND POLYMORPHISMS (Lucio G. Costa, ...
Marco, JL, de los Rios C, Garcia AG, Villarroya M, Carreiras MC, Martins C, Eleuterio A, Morreale A, Orozco M, Luque FJ. 2004. Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors. Bioorganic & medicinal chemistry. 12(9):2199-2218. Abstract ...
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BCHE - Bche - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector shRNA available for purchase from OriGene - Your Gene Company.
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Dibucaine, also known as cinchocaine, is an amino amide local anesthetic. When administered to humans intravenously, it is capable of inhibiting the plasma cholinesterase (butyrylcholinesterase) enzyme. The dibucaine number is used to differentiate individuals who have substitution mutations (point mutations) of the enzymes gene, resulting in decreased enzyme function. Plasma cholinesterase is also known as butyrylcholinesterase, in part because once an individual is given butyrylcholine intravenously, the enzyme converts it to the products butyric acid and choline. This tetrameric enzyme is responsible for the metabolism of a number of substances, including amino ester local anesthetics and succinylcholine, which it hydrolyses in two stages to succinyl monocholine and choline, then to succinic acid and a second molecule of choline. Dibucaine inhibits normal butyrylcholinesterase activity, reducing the ability to convert butyrylcholine to its byproducts. The extent of the catalysis can be ...
Photochromic cholinesterase inhibitors were obtained from cis-1,2-α-dithienylethene-based compounds by incorporating one or two aminopolymethylene tacrine groups. All target compounds are potent acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors in the nanomolar concentration range. Compound 11b bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Yet upon irradiation with light, the mechanism of interaction varied from one photochromic form to another, which was investigated by kinetic studies and proved photoswitchable. The AChE-induced β-amyloid (Aβ) aggregation assay gave further experimental support to this finding: Aβ1-40 aggregation catalyzed by the PAS of AChE might be inhibited by compound 11b in a concentration-dependent manner and seems to occur only with one photochromic form. Computational docking studies provided potential binding modes of the compound. Docking studies and molecular ...
Abstract: Cocaine is recognized as the most reinforcing of all drugs of abuse. There is no anticocaine medication available. The disastrous medical and social consequences of cocaine addiction...
Synthesis of Some New 4,5-Diphenyl 3-(2H) Pyridazinone Derivatives and Evaluation of Their Inhibitory Activities on Acetylcholinesterase Butyrylcholinesterase Enzymes ...
In this study, we focused on four glial proteins that are abundant in amyloid plaques and/or that are known to interact with Abeta: alpha1-antichymotrypsin (ACT), interleukin-1beta (IL-1beta), S100beta, and butyrylcholinesterase (BChE). We examined the ability of these proteins to activate rat cortical astrocyte cultures and to influence the ability of Abeta to activate astrocytes. Treatment of astrocytes with ACT, IL-1beta, or S100beta resulted in glial activation, as assessed by reactive morphology, upregulation of IL-1beta, and production of inducible nitric oxide synthase and nitric oxide. The ability of Abeta to induce astrocyte activation was also enhanced in the presence of each of these three proteins. In contrast, BChE alone did not activate astrocytes and had no effect on Abeta-induced activation ...
73% Less Thermal Damage with ellman® Radiowave Technology. A study at the University of Iowa compared ellman® radiowave technology to two leading low frequency electrosurgery generators6. The purpose of the study was to accurately measure the thermal damage between all three generators.. Each generator used the same electrode model, the ellman® Vari-Tip™ electrode, with a 0.007 inch diameter wire. Ellman manufactured the Vari-Tip™ electrode to fit in the ellman® Surgitron® Dual generator along with the Bovie® 1250 and ValleyLab® Force Fx generators. Each generator was set by the research staff to the optimum power setting to minimize drag on the tissue.. All skin incisions were made on a porcine abdomen. All of the incisions from the ellman®, Bovie® and ValleyLab® generators looked similar with the naked eye.. However, when the tissue samples were histologically examined with Hematoxylin Eosin stain, a dramatic difference was seen.. ...
A single-dose vaccine capable of providing immunity against the effects of cocaine offers a novel and groundbreaking strategy for treating cocaine addiction is described in an article published Instant Online in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc. (http://www.liebertpub.com) The article is available free online at the Human Gene Therapy website (http://www.liebertpub.com/hum).. This is a very novel approach for addressing the huge medical problem of cocaine addiction, says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.. In the article AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior, (http://online.liebertpub.com/doi/pdfplus/10.1089/hum.2011.178) a team of researchers from Weill Cornell Medical College (New York, ...
7. A. M. Matos, J. Crist v o, C. Gomes, A. P. Rauter, C-Glucosyl flavonoid analogues with neuroprotective effects: rational design and synthesis of new CNStargeted drug-like leads against Alzheimers disease, ICS 2016 - XXVIII International Carbohydrate Symposium, New Orleans, USA, julho 2016.. 8. V. Cachatra,* I. Schino, N. Colabufo, A. P. Rauter, Exploratory chemistry of butyrylcholinesterase nucleoside-based inhibitors, CQB Day2016, Lisboa, junho 2016.. ...
FUNCTIONNAL SIGNIFICANCE OF CHOLINESTERASE HYSTERESIS. Most hysteretic enzymes are regulatory enzymes, and it has been suggested that hysteresis may play a physiological role in damping out cellular response to rapid change in substrate or effector concentration [88, 89]. However, the actual role of hysteretic enzymes in cellular regulations has not yet been demonstrated. There is no evidence that hysteresis plays a role in function(s) of BuChE and AChE in the body. Cholinesterases, at least AChE as a regulatory enzyme, play an important role in transmission of nerve influx in the cholinergic system. Otherwise, human plasma BuChE plays a role in detoxification of poisonous esters as an endogenous stoichiometric or catalytic bioscavenger [4]. Since detoxification enzymes are promiscuous, multifunctional enzymes, they are expected to exist as conformational ensembles [90]. Therefore, physiological and/or toxicological relevance for the hysteresis of ChEs cannot be ruled out.. Hysteresis as a ...
French for Yule Log, Buche de Noel is a traditional rolled sponge cake served on Christmas. Ours is distinguished by a rich coffee-flavored cream filling.
Echothiophate iodide reduces pressure in the eye by increasing the amount of fluid that drains from the eye. This also causes the pupil to become smaller, reducing its response to light or dark conditions.
Trauma is associated with use of cocaine. Cocaine can cause agitation, paranoia, distractibility, distorted perception, and depression. All of these may increase the likelihood of violence, suicide, o... more
Trauma is associated with use of cocaine. Cocaine can cause agitation, paranoia, distractibility, distorted perception, and depression. All of these may increase the likelihood of violence, suicide, o... more
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Perform reliable PCR with Bio-Rads BCHE primer pair, for Human. Designed for EvaGreen-based detection with digital PCR (ddPCR).
The Ellman Surgitron FFPF EMC Electrosurgical Unit comes with foot pedal and patient plate. This unit is a high-frequency radiosurgical device that is equipped with an audio tone that indicates when the device is activated. The tone will be heard immediately upon activation of the Surgitron device. This unit features a continuously linear power setting for precise, predictable control. This will promote faster healing with minimal scarring and serves to eliminate unfavorable postoperative conditions such as trauma, swelling, and infection.. ...
Description: Our Expert Technicians will perform a Complete System Diagnosis and repair evaluation. We will contact you with repair price prior to completing the repair.The Ellman Surgitron FFPF EMC Electrosurgical Unit comes with foot pedal and patient plate. This unit is a high-frequency radiosurgical device that is
Die Arbeit hat das Ziel finanzielle Konsequenzen des Klimawandels auf die Forstwirtschaft zu untersuchen. Die Überlebenszeitanalyse der Waldzustandserhebung ermöglichte die Aufstellung Klima- und Mischungsabhängiger Überlebenswahrscheinlichkeiten von Fichte und Buche. Integriert in einer finanziellen Optimierung konnten die Folgen des Klimawandels für Fichten- Buchenbestände auf Datenbasis eines privaten Forstbetriebes abgeschätzt werden. Bei beiden Schritten konnte die große Bedeutung der Beimischung von Buche in Fichtenbeständen zur Risikoabsicherung im Klimawandel sowohl ökologisch sowie finanziell dargelegt werde. Die Arbeit zeigt eine Methodik auf, ökologische Modellierung und finanzielle Optimierung miteinander zu verknüpfen um Entscheidungen in Forstbetrieben zu un¬terstützen. « ...
When you lose your A/a you know without question the time is nigh to order your new keybo*rd. Trouble is, Im finicky when it comes to keybo*rds. You get used to the specifics of one; conforming to the new model is often testy. To further dirty the complexity of my problem, my keybo*rd is built specifically for my type of computer so picking one up from the superstore isnt possible. It must be ordered online. Which I did. But, since I refused to cough up the fees for quick shipping, I found myself confronted with the dire truth of living with my non A/a condition for three to five business 24-hour periods.. ...
doi:10.1016/B978-0-7020-3145-8.00005-3. ISBN 978-0-7020-3145-8. "Butyrylcholinesterase". OMIM. Retrieved 4 September 2015. ...
It inhibits acetylcholinesterase and butyrylcholinesterase. Phorate is most commonly applied in granular form. It is non- ...
Pohanka, Miroslav; Dobes, Petr (8 May 2013). "Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase". ...
It is also a butyrylcholinesterase inhibitor. Ethephon often used on wheat, coffee, tobacco, cotton, and rice in order to help ... Zhang, Nanjing; Casida, John E (2002). "Novel Irreversible Butyrylcholinesterase Inhibitors: 2-Chloro-1-(substituted-phenyl) ...
Butyrylcholinesterase currently is the preferred enzyme for development as a pharmaceutical drug primarily because it is a ... Butyrylcholinesterase is under development by the U.S. Department of Defense as a prophylactic countermeasure against ... Lockridge O (April 2015). "Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the ... Ashani Y, Shapira S, Levy D, Wolfe AD, Doctor BP, Raveh L (January 1991). "Butyrylcholinesterase and acetylcholinesterase ...
Structural analysis shows effects on TRP channels and butyrylcholinesterase. https://www.thefreelibrary.com/Ethnobotany+%26+ ...
Appa Rao Allam, Sridhar Gumpeny, Undurti Narasimha Das (7 August 2008). "Butyrylcholinesterase as a marker of low-grade ... Appa Rao Allam, Sridhar Gumpeny, Undurti Narasimha Das (7 August 2008). "Butyrylcholinesterase as a marker of low-grade ... and Methods for selectively occluding blood supplies to neoplasias and Butyrylcholinesterase as a marker of low-grade systemic ...
Also a reversible inhibition of butyrylcholinesterase can take place. The function of butyrylcholinesterase is not fully ...
Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). ... Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity. Chelidonine ... Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase (a nonspecific cholinesterase) ...
Sertraline and amitriptyline inhibit butyrylcholinesterase and cause prolonged paralysis. Mivacurium causes prolonged paralysis ... Succinylcholine is metabolised by butyrylcholinesterase (aka psuedocholinesterase or plasma cholinesterase). Contraindications ...
Adsersen, A.; Kjølbye, A.; Dall, O.; Jäger, A. K. (Aug 2007). "Acetylcholinesterase and Butyrylcholinesterase Inhibitory ...
"Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase". Archives of Biochemistry and Biophysics ...
This group of inhibitors is divided into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase ... Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. In 2015, the United ...
Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana. Frontiers in Plant Science ... Purification, Characterization, and N-glycosylation of Recombinant Butyrylcholinesterase from Transgenic Rice Cell Suspension ... Semicontinuous bioreactor production of recombinant butyrylcholinesterase in transgenic rice cell suspension cultures. ... to investigate the production of human butyrylcholinesterase (BuChE), an enzyme used to treat the effects of chemical warfare ...
Kamal MA, Klein P, Luo W, Li Y, Holloway HW, Tweedie D, Greig NH (May 2008). "Kinetics of human serum butyrylcholinesterase ... Kamal MA, Al-Jafari AA, Yu QS, Greig NH (February 2006). "Kinetic analysis of the inhibition of human butyrylcholinesterase ... November 2005). "Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers ... A number of cymserine derivatives have been developed with much greater selectivity for butyrylcholinesterase, and both ...
Butyrylcholinesterase (EC 3.1.1.8) (BCHE), also known as cholinesterase, choline esterase II, BChE, BuChE, pseudocholinesterase ... The other type is butyrylcholinesterase (also called choline esterase II or plasma cholinesterase); it is found mainly in the ... The term cholinesterase is sometimes used to refer specifically to butyrylcholinesterase, but this usage produces the oddity ... Clinically useful quantities of butyrylcholinesterase were synthesized in 2007 by PharmAthene, through the use of genetically ...
"The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency". Journal of Pharmacology and ... These patients should notify others in their family who may be at risk for carrying one or more abnormal butyrylcholinesterase ... Mivacurium, like succinylcholine, is a muscle relaxant and will have prolonged action in those with butyrylcholinesterase ... "Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India". Pharmacogenetics and ...
... is an acetylcholinesterase inhibitor and butyrylcholinesterase inhibitor isolated from Tabernaemontana. Vieira, IJ; ...
"Developing procedures for the large-scale purification of human serum butyrylcholinesterase". Protein Expression and ...
Masson, Patrick; Lockridge, Oksana (February 2010). "Butyrylcholinesterase for protection from organophosphorus poisons: ... This metabolite can bind to butyrylcholinesterase (BuChE) and/or acetylcholinesterase (AChE). Binding to BuChE results in no ...
Butyrylcholinesterase activity returns to normal approximately two weeks after bambuterol is stopped. It can also enhance the ...
Hydrolysis is both non-enzymatic and enzymatic, the latter mainly by butyrylcholinesterase. The acid metabolite has a plasma ...
... and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera". Fisheries Science. 74 ...
"Reaction Pathway and Free Energy Profiles for Butyrylcholinesterase-Catalyzed Hydrolysis of Acetylthiocholine". Biochemistry. ...
"Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase". ...
Inherited reductions in butyrylcholinesterase activity occur because of mutations at a single autosomal location on the long ... Dibucaine inhibits normal butyrylcholinesterase activity, reducing the ability to convert butyrylcholine to its byproducts. The ... More recently, Gaffney and Campbell have described a PCR-based method to identify the Kalow allele for butyrylcholinesterase. A ... Reduced butyrylcholinesterase activity may occur as a result of inherited or acquired causes. ...
"Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents". Journal of ...
... modeling beta-galactosidase and butyrylcholinesterase". Biochimica et Biophysica Acta (BBA) - General Subjects. 1770 (5): 733- ...
... s are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase ...
A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors". ...
It is used as a tool to distinguish between acetylcholinesterase and butyrylcholinesterase. Butyrylcholinesterase may be a ... Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and ... Butyrylcholinesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Human BCHE genome location and ... Butyrylcholinesterase (HGNC symbol BCHE; EC 3.1.1.8), also known as BChE, BuChE, pseudocholinesterase, or plasma (cholin) ...
54 Studies found for: Nervous System Diseases , BUTYRYLCHOLINESTERASE. Also searched for Cholinesterase, Disorders, and ... Brain Changes by Rivastigmine According to Butyrylcholinesterase Alleles. *Alzheimer's Disease ...
Protein target information for Butyrylcholinesterase (horse). Find diseases associated with this biological target and ...
Butyrylcholinesterase attenuates amyloid fibril formation in vitro [5].. *Analysis of the butyrylcholinesterase gene and nearby ... Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimers disease in Koreans. Kim, ... Relation between butyrylcholinesterase K variant, paraoxonase 1 (PON1) Q and R and apolipoprotein E epsilon 4 genes in early- ... Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin ...
... products for your research including Butyrylcholinesterase/BCHE Small Molecules and Butyrylcholinesterase/BCHE ELISAs. ... Butyrylcholinesterase/BCHE: Products. Butyrylcholinesterase (BCHE) is a major acetylcholine hydrolyzing enzyme in the ...
... are reported to have homozygous wild-type butyrylcholinesterase (BuChE) gene expression. It is associated with a higher rate of ... Kehoe, P.G., Williams, H., Holmans, P., Wilcock, G., Cairns, N.J., Neal, J. and Owen, M.J. (1998) The Butyrylcholinesterase K ... Mueller, B. and Adler, G. (2015) Prevalence of Wild-Type Butyrylcholinesterase Genotype in Patients with Alzheimers Dementia. ... Sodeyama, N., Yamada, M., Itoh, Y., Otomo, E., Suematsu, N. and Matsushita, M. (1999) Association between Butyrylcholinesterase ...
... butyrylcholinesterase deficiency explanation free. What is butyrylcholinesterase deficiency? Meaning of butyrylcholinesterase ... Looking for online definition of butyrylcholinesterase deficiency in the Medical Dictionary? ... butyrylcholinesterase deficiency. butyrylcholinesterase deficiency. An autosomal recessive MIM 177400 defect in ... Butyrylcholinesterase deficiency identified after succinylcholine administration.. Butyrylcholinesterase deficiency identified ...
Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates.. Arpagaus M1, ... A phylogenetic tree of mammalian butyrylcholinesterases was constructed using the partial BCHE sequences. ... and chicken DNA were hybridized with probes derived from the four exons of the human butyrylcholinesterase gene (BCHE) ( ...
All the compounds were found to inhibit butyrylcholinesterase. The most active compound shows 50% inhibition at a concentration ... Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase A. A. Altaf, M. ... confirmed the limited effects of the H-bonding in the presence and absence of water in the active site of butyrylcholinesterase ...
K. Hidaka, I. Iuchi, T. Yamasaki, N. Ueda, and K. Hukano, "Nonsense mutation in exon 2 of the butyrylcholinesterase gene: a ... K. Sudo, M. Maekawa, T. Kanno, S. Akizuki, and T. Magara, "Three different point mutations in the butyrylcholinesterase gene of ... S. Levano, H. Ginz, M. Siegemund, M. Filipovic, E. Voronkov, A. Urwyler, and T. Girard, "Genotyping the butyrylcholinesterase ... Prolonged Neuromuscular Blockade Following Succinylcholine Administration to a Patient with a Reduced Butyrylcholinesterase ...
Goat Polyclonal Anti-Butyrylcholinesterase/BCHE Antibody [Unconjugated]. Validated: WB, IHC. Tested Reactivity: Mouse, Rat. 100 ... Home » Butyrylcholinesterase/BCHE » Butyrylcholinesterase/BCHE Antibodies » Butyrylcholinesterase/BCHE Antibody [Unconjugated] ... Blogs on Butyrylcholinesterase/BCHE. There are no specific blogs for Butyrylcholinesterase/BCHE, but you can read our latest ... PTMs for Butyrylcholinesterase/BCHE Antibody (AF9024). Learn more about PTMs related to Butyrylcholinesterase/BCHE Antibody ( ...
Order monoclonal and polyclonal Butyrylcholinesterase antibodies for many applications. Selected quality suppliers for anti- ... Browse our anti-Butyrylcholinesterase (BCHE) Antibodies. Full name:. anti-Butyrylcholinesterase Antibodies (BCHE). On www. ... More Antibodies against Butyrylcholinesterase Interaction Partners. Human Butyrylcholinesterase (BCHE) interaction partners * ... Show all anti-Butyrylcholinesterase (BCHE) Antibodies with Pubmed References. * Human Monoclonal Butyrylcholinesterase Primary ...
Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two ... BUTYRYLCHOLINESTERASE protein, length: 529 (BLAST) Sequence Similarity Cutoff. Rank. Chains in Cluster. Cluster ID / Name. ...
... and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard ... Novel Bisquaternary Oximes-Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Kamil Kuca 1, ... "Novel Bisquaternary Oximes-Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon." Molecules 14 ... Keywords: acetylcholinesterase; butyrylcholinesterase; reactivator; nerve agent; oxime; pesticide; scavenger ...
Overview of Butyrylcholinesterase deficiency as a medical condition including introduction, prevalence, prognosis, profile, ... What causes Butyrylcholinesterase deficiency?. Causes of Butyrylcholinesterase deficiency: see causes of Butyrylcholinesterase ... Symptoms of Butyrylcholinesterase deficiency: see symptoms of Butyrylcholinesterase deficiency Butyrylcholinesterase deficiency ... Main name of condition: Butyrylcholinesterase deficiency Other names or spellings for Butyrylcholinesterase deficiency: BCHE ...
... specific to butyrylcholinesterase (BChE). This probe was rationally designed by mimicking the native substrate and optimized ... Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy S. Yang, Q. Sun, H. Xiong, S. Liu, B ... Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy ... specific to butyrylcholinesterase (BChE). This probe was rationally designed by mimicking the native substrate and optimized ...
Mouse Monoclonal Anti-Butyrylcholinesterase/BCHE Antibody (3E8) - BSA Free. Validated: ELISA. Tested Reactivity: Human. 100% ... Additional Butyrylcholinesterase/BCHE Products. Butyrylcholinesterase/BCHE NBP1-05127 * Butyrylcholinesterase/BCHE Antibodies. ... Home » Butyrylcholinesterase/BCHE » Butyrylcholinesterase/BCHE Antibodies » Butyrylcholinesterase/BCHE Antibody (3E8) - BSA ... Butyrylcholinesterase/BCHE Antibody (3E8) - BSA Free Summary. Immunogen. Butyrylcholinesterase isolated from human plasma and ...
Study to Investigate the Safety and Tolerability of AZD8848 in Butyrylcholinesterase Deficient Subjects. The safety and ... Butyrylcholinesterase deficiency. tolerability. safety. AZD8848. pharmacokinetics. pharmacodynamics. BChE deficient subjects ... The purpose of this study is to investigate the safety and tolerability of AZD8848 in Butyrylcholinesterase deficient subjects ... and Pharmacodynamics of Single Ascending Doses of AZD 8848 Administered Intranasally to Male and Female Butyrylcholinesterase ...
... the effects of the location of the tertiary amine groups as well as of other groups on AChE and butyrylcholinesterase (BChE) ... Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: ... investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase ... relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase ...
We successfully incorporated ferulic acid or lipoic acid groups producing potent selective inhibitors of butyrylcholinesterase ... Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of ... Jones, M.; Wang, J.; Harmon, S.; Kling, B.; Heilmann, J.; Gilmer, J.F. Novel Selective Butyrylcholinesterase Inhibitors ... Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics ...
RP-HPLC-DAD-MS(n) Analysis and Butyrylcholinesterase Inhibitory Activity of Barbacenia blanchetii Extracts.. [Jósquia S Barbosa ... At the same time, these extracts were evaluated against butyrylcholinesterase using Ellmans method. All extracts inhibited ...
The purpose of this study is to synthesize and evaluate specific agents for molecular imaging of butyrylcholinesterase (BuChE ... PURPOSE: The purpose of this study is to synthesize and evaluate specific agents for molecular imaging of butyrylcholinesterase ...
... and butyrylcholinesterase (BChE)]. The total phenol contents and antioxidant activities as typified by their 2,2′-azino-bis(3- ... 2.5.2. Butyrylcholinesterase (BChE) Inhibition Assay. Inhibition of BChE was assessed by a modified colorimetric method of ... Butyrylcholinesterase inhibitory activity of infusions of green tea and some citrus peels. Values represent means ± standard ... EC50 values of inhibition of monoamine oxidase, butyrylcholinesterase, and Fe2+ chelating abilities of green tea and some ...
Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two ... X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging. ...
Buy high purity Butyrylcholinesterase (BChE) from equine serum for in vitro diagnostic manufacturing and clinical research uses ... Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and ... Butyrylcholinesterase (BCHE, or BuChE), is a non-specific cholinesterase enzyme that hydrolyses many different choline esters. ... Lee Biosolutions is the leading supplier of horse serum Butyrylcholinesterase (BCHE) for research and diagnostic manufacturing. ...
Butyrylcholinesterase,(rBChE),May,Play,A,Neuroprotective,Role,in,Alzheimers,Disease,medicine,advanced medical technology, ... PharmAthenes Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimers Disease ... About Protexia(R): Recombinant Human Butyrylcholinesterase (rBChE) Protexia is a pegylated form of recombinant human ... have recently obtained new data suggesting that recombinant butyrylcholinesterase (rBChE), a non-pegylated form of Protexia(R ...
These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most ... Acetylcholinesterase/drug effects; Animals; Butyrylcholinesterase/drug effects; Calcium Channels/drug effects; Cattle; ... and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca(2+) channels and nicotinic receptors, are ... modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and ...
Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline ... and high selectivity index of AChE over butyrylcholinesterase (BuChE). Compound 12b exhibited the most potent AChE inhibitory ...
... Mediators ... We hypothesized that the activity of butyrylcholinesterase (BChE) might serve as a marker to identify and prognose systemic ... A POCT approach, used to assess butyrylcholinesterase activity, might further improve the therapy of the critically ill ...
Butyrylcholinesterase is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms ... Looking for online definition of Butyrylcholinesterase or what Butyrylcholinesterase stands for? ... 01 mol/L iso-OMPA as an inhibitor of butyrylcholinesterase (BuChE, EC 3.. Effect of (R)-salsolinol and N-methyl-(R)-salsolinol ... Trichloroethylene: Further studies of the effects on body and organ weights and plasma butyrylcholinesterase activity in mice. ...
  • Butyrylcholinesterase (BCHE) is a major acetylcholine hydrolyzing enzyme in the circulation. (rndsystems.com)
  • Butyrylcholinesterase/BCHE " has 8 results in Products. (rndsystems.com)
  • A phylogenetic tree of mammalian butyrylcholinesterases was constructed using the partial BCHE sequences. (nih.gov)
  • Detects mouse and rat Butyrylcholinesterase/BCHE in direct ELISAs and Western blots. (novusbio.com)
  • On www.antibodies-online.com are 148 Butyrylcholinesterase (BCHE) Antibodies from 27 different suppliers available. (antibodies-online.com)
  • We report herein the structure-based design and application of a fluorogenic molecular probe ( BChE-FP ) specific to butyrylcholinesterase (BChE). (rsc.org)
  • There are currently no images for Butyrylcholinesterase/BCHE Antibody (NBP1-05127). (novusbio.com)
  • However, the effects of the location of the tertiary amine groups as well as of other groups on AChE and butyrylcholinesterase (BChE) activity have not been reported. (springer.com)
  • Some of the therapeutic targets that have been identified in the management of neurodegenerative conditions include monoamine oxidase (MAO), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and oxidative stress [ 1 ]. (hindawi.com)
  • Lee Biosolutions is the leading supplier of horse serum Butyrylcholinesterase (BCHE) for research and diagnostic manufacturing. (leebio.com)
  • Butyrylcholinesterase (BCHE, or BuChE), is a non-specific cholinesterase enzyme that hydrolyses many different choline esters. (leebio.com)
  • We hypothesized that the activity of butyrylcholinesterase (BChE) might serve as a marker to identify and prognose systemic inflammation. (nih.gov)
  • Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene. (thefreedictionary.com)
  • The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition activity was performed according to the method of Ellman [20] with slight modifications. (thefreedictionary.com)
  • Abbreviations BChE butyrylcholinesterase AChE acetylcholinesterase MD molecular docking N. (thefreedictionary.com)
  • Deficiency in butyrylcholinesterase (BChE), a condition commonly noticed in liver damage, inflammation, and malnutrition, has previously been associated with impaired prognosis in different malignancies. (springer.com)
  • Für erniedrigte Butyrylcholinesterase(BChE)-Spiegel, die üblicherweise im Rahmen von Leberschäden, Entzündungsreaktionen oder Mangelernährung auftreten, wurden kürzlich auch Assoziationen mit schlechterem Überleben in verschiedenen onkologischen Erkrankungen beschrieben. (springer.com)
  • Butyrylcholinesterase (BChE) belongs to the same structural class of proteins as acetylcholinesterase (AChE). (celltechnology.com)
  • The Fluoro Butyrylcholinesterase Activity kit is designed to quantitatively measure butyryl- cholinesterase (BChE) activity in a variety of samples such as serum or plasma, cell and tissue lysates. (celltechnology.com)
  • It has been recognized that an ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. human BChE (butyrylcholinesterase)-catalysed hydrolysis. (biochemj.org)
  • Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation process is rate-determining. (uky.edu)
  • The aim of this work was to evaluate the potential of chia seeds to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. (ejbiotechnology.info)
  • Two major genotypes are known to affect the development and progression of Alzheimer's disease (AD) and its response to cholinesterase inhibitors: the apolipoprotein E (ApoE) and butyrylcholinesterase genes (BChE). (ebscohost.com)
  • To investigate the possible involvement of the butyrylcholinesterase (BCHE) K variant and transferrin (TF) C2 variant in the manifestation of Alzheimer's disease (AD), we analyzed the BCHE, TF and apolipoprotein E (APOE) genotypes of 164 sporadic AD patients and 239 normal elderly. (ebscohost.com)
  • Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes. (eurekaselect.com)
  • Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). (eurekaselect.com)
  • Butyrylcholinesterase (BChE) is an enzyme which has been shown to be involved in the pathogenesis, treatment and prognosis of Alzheimer's disease. (scirp.org)
  • Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE). (cdc.gov)
  • Butyrylcholinesterase (BChE) binds to NAs, rendering the chemicals harmless to acetylcholinesterase. (uoguelph.ca)
  • Butyrylcholinesterase BChE metabolizes cocaine, and genetic variants of the BChE gene BCHE alter its catalytic activity. (duhnnae.com)
  • The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes hCA I and hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes were evaluated. (bartin.edu.tr)
  • A chemical in jet engine oil, the neurotoxicant tri-o-cresyl phosphate, after metabolic activation to cresyl saligenin phosphate makes a covalent adduct on butyrylcholinesterase (BChE). (elsevier.com)
  • The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability. (qxmd.com)
  • Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimer's disease (AD) risk, the results are still controversial. (medscimonit.com)
  • Together with the apolipoprotein E4 (APOE-ɛ4) gene, butyrylcholinesterase (BCHE) has become recently one of the few Alzheimer's disease (AD) susceptibility genes with distinct pharmacogenomic properties.OBJECTIVE: To validate candidate genes (APOE/BCHE) which display associations with age of onset of AD and donepezil efficacy in aMCI subjects.METHODS: Using the Petersen et al. (mcgill.ca)
  • The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the ε4 allele of the apolipoprotein E (APOE) gene. (elsevier.com)
  • Butyrylcholinesterase (BChE) is the evolutionary counterpart to acetylcholinesterase (AChE). (researchwithrutgers.com)
  • Butyrylcholinesterase (BChE), an ester hydrolase produced mainly by the liver, hydrolyzes certain short-acting neuromuscular blocking agents, like succinylcholine and mivacurium that are widely used during anesthesia. (beds.ac.uk)
  • Approximately, two-thirds patients with Alzheimer's disease (AD) are reported to have homozygous wild-type butyrylcholinesterase (BuChE) gene expression. (scirp.org)
  • We successfully incorporated ferulic acid or lipoic acid groups producing potent selective inhibitors of butyrylcholinesterase (BuChE). (mdpi.com)
  • PURPOSE: The purpose of this study is to synthesize and evaluate specific agents for molecular imaging of butyrylcholinesterase (BuChE), known to be associated with neuritic plaques and neurofibrillary tangles in Alzheimer's disease (AD). (biomedsearch.com)
  • The synthesis and the biological activity of compounds 5-40 as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca(2+) channels and nicotinic receptors, are described. (ub.edu)
  • These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most active molecules ranges from 10.0 (compound 29) to 76.9 (compound 16). (ub.edu)
  • The cholinesterase inhibition assays indicated that most synthesized compounds exhibited good activity for acetylcholinesterase (AChE) and high selectivity index of AChE over butyrylcholinesterase (BuChE). (sigmaaldrich.com)
  • Among the various biomarkers of pesticides exposure, the family of cholinesterases [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] have widely been used as biomarker to evaluate the noxious effects of pesticides i. (thefreedictionary.com)
  • 01 mol/L iso-OMPA as an inhibitor of butyrylcholinesterase (BuChE, EC 3. (thefreedictionary.com)
  • This investigation examined the utility of three recombinant protein-expression systems (COS cells, insect cells and insect larvae) to cost-effectively produce biologically active human butyrylcholinesterase (BuChE). (unl.edu)
  • Fourth, a related enzyme, butyrylcholinesterase (BuChE), capable of hydrolyzing acetylcholine, is expressed in some of the same sites as AChE, including the neuromuscular junction (for review see Chatonnet and Lockridge, 1989 ). (rupress.org)
  • In attempting to determine the amino acid residues involved in the aging of butyrylcholinesterase (BuChE), the human BuChE gene was mutated at several positions corresponding to residues located at the rim of the active site gorge and in the vicinity of the active site. (nebraska.edu)
  • The most frequent polymorphism of butyrylcholinesterase (BuChE), the K-variant, has been proposed as a risk factor for AD, but data regarding its influence on early disease progression is still limited. (cdc.gov)
  • Aim: The aim of the following study isto screen the plant species for both acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) inhibition by in-vitro Ellman's method and a thin layer chromatography bioautographic assay for newer drug candidates for the treatment of Alzheimer's disease. (pharmacognosy.in)
  • When tested with partially purified enzyme preparations, DAPA was a potent inhibitor of butyrylcholinesterase (IC 50 = 2 × 10 -7 M) but not of acetylcholinesterase (IC 50 = 4 × 10 -4 M). For a detailed study of the effects of DAPA on butyrylcholinesterase (BuChE), the enzyme was purified to homogeneity from horse serum, with the aid of affinity chromatography on N-methyl acridinium. (elsevier.com)
  • The effect of non-ionic detergents like Triton X-100 , Lubrol PX , Brij 35 and Tween 80 on the esterase activity and inhibitor sensitivity of human serum butyrylcholinesterase (BuChE) were studied. (bvsalud.org)
  • they also lacked asymmetric forms of the AChE homologue, butyrylcholinesterase. (rupress.org)
  • Thus, products of the ColQ gene are required for assembly of all detectable asymmetric AChE and butyrylcholinesterase. (rupress.org)
  • Butyrylcholinesterase is produced by the liver and is secreted into the circulation, unlike acetylcholinesterase (AChE), the other member of the enzyme family. (scirp.org)
  • Enzymes terminating ACh action, acetylcholinesterase (AChE) and butyrylcholinesterase, were revealed in perivascular meningeal nerves. (frontiersin.org)
  • Butyrylcholinesterase (BChE1, EC 3.1.1.8) is a serinehydrolase related to acetylcholinesterase (AChE, EC3.1.1.7). (vdocuments.site)
  • Butyrylcholinesterase deficiency identified after succinylcholine administration. (thefreedictionary.com)
  • Butyrylcholinesterase deficiency identified by preoperative patient interview. (thefreedictionary.com)
  • What is Butyrylcholinesterase deficiency? (rightdiagnosis.com)
  • A metabolic disorder involving an enzyme (butyrylcholinesterase) deficiency. (rightdiagnosis.com)
  • Butyrylcholinesterase deficiency is listed as a " rare disease " by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). (rightdiagnosis.com)
  • This means that Butyrylcholinesterase deficiency, or a subtype of Butyrylcholinesterase deficiency, affects less than 200,000 people in the US population. (rightdiagnosis.com)
  • What are the symptoms of Butyrylcholinesterase deficiency? (rightdiagnosis.com)
  • see tests for Butyrylcholinesterase deficiency . (rightdiagnosis.com)
  • see misdiagnosis and Butyrylcholinesterase deficiency . (rightdiagnosis.com)
  • Yamamoto, Y., Yasuda, M., Mori, E. and Maeda, K. (1999) Failure to Confirm a Synergistic Effect between the K-Variant of the Butyrylcholinesterase Gene and the Epsilon4 Allele of the Apolipoprotein Gene in Japanese Patients with Alzheimer's Disease. (scirp.org)
  • Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease. (ebscohost.com)
  • Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation. (ebscohost.com)
  • The genotype was determined by amplifying the butyrylcholinesterase gene, digesting the amplified DNA and analyzing for characteristic band sizes on agarose gels. (health.mil)
  • These results were obtained by DNA sequence analysis of the butyrylcholinesterase gene after amplification by PCR. (elsevier.com)
  • Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo. (qxmd.com)
  • Itwas found that the negative charges of tetrahedral intermediates were more stabilized by orthoelectron-withdrawing substituents of the inhibitors in butyrylcholinesterase than in acetyl-cholinesterase. (vdocuments.site)
  • X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger. (proteopedia.org)
  • Nachon F, Carletti E, Wandhammer M, Nicolet Y, Schopfer LM, Masson P, Lockridge O. X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger. (proteopedia.org)
  • Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives. (sigmaaldrich.com)
  • Kiss, "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity," Acta Pharmaceutica, vol. (thefreedictionary.com)
  • Butyrylcholinesterase catalyzes the hydrolysis of esters of choline, including acetylcholine, butyrylcholine, and succinylcholine, as well as the hydrolysis of esters such as cocaine, acetylsalicylic acid and heroin. (openanesthesia.org)
  • The effect of butyrylcholinesterase on onset and duration of action of succinylcholine is therefore exerted by the rate of hydrolysis of succinylcholine before it reaches, and after it leaves the NMJ. (openanesthesia.org)
  • Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants. (wizdom.ai)
  • These synthesized compounds were characterized by EI-MS, 1H-NMR spectral techniques and were also evaluated against a-glucosidase and butyrylcholinesterase enzymes. (thefreedictionary.com)
  • Gulcin, I. The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes. (eurekaselect.com)
  • P. harmala had inhibitory activities on acetylcholinesterase and butyrylcholinesterase. (greenmedinfo.com)
  • Computational studies confirmed the limited effects of the H-bonding in the presence and absence of water in the active site of butyrylcholinesterase, supporting the importance of hydrophobicity for inhibitors of this enzyme. (rsc.org)
  • Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase. (semanticscholar.org)
  • Interaction of Triton X-100 with acyl pocket of butyrylcholinesterase: effect on esterase activity and inhibitor sensitivity of the enzyme. (bvsalud.org)
  • BNC is a centrally active, reversible butyrylcholinesterase inhibitor, and targets advanced Alzheimer's. (thefreedictionary.com)
  • It is also a butyrylcholinesterase inhibitor. (wikipedia.org)
  • To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase. (ebscohost.com)
  • Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. (ebscohost.com)
  • Schopfer LM, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O (2017) The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment. (springer.com)
  • Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease. (cdc.gov)
  • The fluoride variant of human butyrylcholinesterase owes its name to the observation that it is resistant to inhibition by 0.050 mM sodium fluoride in the in vitro assay. (elsevier.com)
  • CONCLUSIONS: This finding is consistent with the suggestion that the K variant of butyrylcholinesterase has an important role in disease progression in AD, and this may have implications for treatment. (ox.ac.uk)
  • Mueller, B. and Adler, G. (2015) Prevalence of Wild-Type Butyrylcholinesterase Genotype in Patients with Alzheimer's Dementia. (scirp.org)
  • Alzheimer's disease appears to be associated with decreased acetylcholinesterase activity and an increase in Butyrylcholinesterase activity. (celltechnology.com)
  • Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects. (cdc.gov)
  • In conclusion, electron-donating substituents in the orthoposition were better inhibitors of butyrylcholinesterase than acetylcholinesterase, whileelectron-withdrawing substituents were better inhibitors of acetylcholinesterase. (vdocuments.site)
  • Selective Butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. (celltechnology.com)
  • Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (leebio.com)
  • Butyrylcholinesterase (pseudocholinesterase) is a serine hydrolase synthesized in the liver and present in the plasma. (openanesthesia.org)
  • The present study reports the effects of an ascorbic acid-deficient diet on liver and plasma butyrylcholinesterase activity. (ac.ke)
  • All the compounds were found to inhibit butyrylcholinesterase. (rsc.org)
  • Isosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. (mdpi.com)
  • PharmAthene's Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimer. (bio-medicine.org)
  • PIP ) a biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological threats, announced today that scientists from the Hebrew University of Jerusalem, one of PharmAthene's collaboration partners, have recently obtained new data suggesting that recombinant butyrylcholinesterase (rBChE), a non-pegylated form of Protexia(R), may have neuroprotective benefits. (bio-medicine.org)
  • The major goal of the ASU project is to provide KBP with expertise in protein engineering to create a recombinant butyrylcholinesterase (rBChE) that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBChE) butyrylcholinesterase. (elsevier.com)
  • Additionally we are shipping Butyrylcholinesterase Kits (38) and Butyrylcholinesterase Proteins (21) and many more products for this protein. (antibodies-online.com)
  • These compounds inhibitacetylcholinesterase and butyrylcholinesterase. (vdocuments.site)
  • Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses. (thefreedictionary.com)
  • We tested the frequency of butyrylcholinesterase genetic variants in 226 veterans. (health.mil)
  • Synthesis and preliminary evaluation of piperidinyl and pyrrolidinyl iodobenzoates as imaging agents for butyrylcholinesterase. (biomedsearch.com)
  • Supuran, C.T. Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. (eurekaselect.com)
  • The synthesis and preliminary results for acetylcholinesteraseand butyrylcholinesterase inhibition activation of a series of pyrano[2,3-b]quinolines 2, 3) and benzonaphthyridines 5, 6) derivatives are described. (uab.cat)
  • Butyrylcholinesterase is a tetrameric glycoprotein (molecular mass of 350 kDa), and consists of four subunits, each with molecular mass of 90 kDa (1). (novusbio.com)
  • Multiple molecular forms of human plasma butyrylcholinesterase I. Apparent molecular parameters and broad pattern of the quaternary structure. (springer.com)
  • The inhibition of horse serum butyrylcholinesterase (EC 3.1.1.8) by the organophosphorus compound paraoxon (diethyl 4-nitrophenyl phosphate) was studied by flow microcalorimetry at 37 degrees C in Tris buffer (pH 7.5) using a modification of the kinetic model described by Stojan and coworkers [J. Stojan, V. Marcel, S. Estrada-Mondaca, A. Klaebe, P. Masson, D. Fournier, A putative kinetic model for substrate metabolisation by Drosophila acetylcholinesterase, FEBS Lett. (archives-ouvertes.fr)
  • RP-HPLC-DAD-MS(n) Analysis and Butyrylcholinesterase Inhibitory Activity of Barbacenia blanchetii Extracts. (sigmaaldrich.com)
  • A POCT approach, used to assess butyrylcholinesterase activity, might further improve the therapy of the critically ill patients by minimizing time delays between the clinical assessment and treatment of the inflammatory process. (nih.gov)
  • Hence, assessing butyrylcholinesterase activity might help in early detection of inflammation. (nih.gov)
  • Trichloroethylene: Further studies of the effects on body and organ weights and plasma butyrylcholinesterase activity in mice. (thefreedictionary.com)
  • 5.To see if Gulf War Illness correlates with butyrylcholinesterase activity level or genotype. (health.mil)
  • Blood samples were tested for butyrylcholinesterase activity and phenotype with a spectrophotometric assay. (health.mil)
  • The butyrylcholinesterase activity of some of these molecules is also discussed. (uab.cat)
  • Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. (ac.rs)
  • Congeneric set of thirty-eight 4-aryl-4-oxo-2-(N-aryl/cycloalkyl)butanamides has been designed, synthesized and evaluated for acetyl- and butyrylcholinesterase inhibitory activity. (ac.rs)
  • Engineering of human butyrylcholinesterase by substitution of histidine for glycine at position 117 led to the creation of OP hydrolase activity. (proteopedia.org)
  • Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans. (celltechnology.com)
  • Human butyrylcholinesterase (hBChE) hydrolyzes or scavenges a wide range of toxic esters, including heroin, cocaine, carbamate pesticides, organophosphorus pesticides, and nerve agents. (proteopedia.org)
  • Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. (proteopedia.org)
  • Bosak A, Opsenica D, Šinko G, Zlatar M, Kovarik Z. Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase. (ac.rs)
  • Butyrylcholinesterase: Structure and Physiological Importance. (celltechnology.com)
  • 6] Cokugras, A.N. (2003) Butyrylcholinesterase: Structure and physiological importance. (scirp.org)
  • Butyrylcholinesterase K and Apolipoprotein ε4 Affect Cortical Thickness and Neuropsychiatric Symptoms in Alzheimerµs Disease. (ebscohost.com)
  • Butyrylcholinesterase is a scavenger of nerve agents. (health.mil)
  • Specific for butyrylcholinesterase from human serum or plasma. (novusbio.com)
  • Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice. (qxmd.com)