Cholinergic Antagonists
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Psychotropic Drugs
Parasympatholytics
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Ulnar Neuropathies
Disease involving the ULNAR NERVE from its origin in the BRACHIAL PLEXUS to its termination in the hand. Clinical manifestations may include PARESIS or PARALYSIS of wrist flexion, finger flexion, thumb adduction, finger abduction, and finger adduction. Sensation over the medial palm, fifth finger, and ulnar aspect of the ring finger may also be impaired. Common sites of injury include the AXILLA, cubital tunnel at the ELBOW, and Guyon's canal at the wrist. (From Joynt, Clinical Neurology, 1995, Ch51 pp43-5)
Osteotomy, Le Fort
Transverse sectioning and repositioning of the maxilla. There are three types: Le Fort I osteotomy for maxillary advancement or the treatment of maxillary fractures; Le Fort II osteotomy for the treatment of maxillary fractures; Le Fort III osteotomy for the treatment of maxillary fractures with fracture of one or more facial bones. Le Fort III is often used also to correct craniofacial dysostosis and related facial abnormalities. (From Dorland, 28th ed, p1203 & p662)
Strongyloides stercoralis
Encyclopedias as Topic
Propofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Anesthetics, General
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Anesthetics, Intravenous
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Nausea
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Commerce
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Marketing of Health Services
Bedding and Linens
Silicones
Cosmetic Techniques
Silicone Oils
Callosities
Silicone Elastomers
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Dysbiosis
Polypharmacology
Pharmacoepidemiology
The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))
Research and identification of tranquillizers - use of retention index. (1/98)
At the request of the Service des Haras, our laboratory works on the toxicological problems of the sport-horse. These studies have resulted in the setting up of an anti-doping control for equestrian competitions of various types, not only flat racing. During events, horses, must be calm and docile to the riders' order. Frequently, the latter use tranquillizers to try and win events. The analytical method for the research and identification of these compounds is described. The technique involves successively: 1. alkalinisation of the sample - saliva, blood or urine after enzymatic hydrolysis. 2. extraction with diethyl ether - the recovery is 70% to 90% depending upon the drug. 3. determination by gas-liquid chromatography with use of a retention index for qualitative analysis. We can detect up to fifteen tranquillizers in any one sample, even when present at such low concentrations as found in saliva. The use of the retention index is a reliable method for qualitative analysis. For example, the method has been used for three years, during which period the rentention index of acetylpromazine remained at 3240 +/- 7. The chromatographic analysis was performed on 3% OV-17 at 290 degrees. The chromatographic analysis has been performed by three columns of different polarity (OV-1; OV-17; SP-2250). If on the three columns, the retention index of one peak is the same as that of the tranquilizer, a further confirmation is made with the use of a thermionic detector specific for nitrogenous drugs. In conclusion, this method which is sufficiently precise and specific has been used for anti-doping control. (+info)Densitometric determination of impurities in pharmaceuticals. Part VI. Determination of 4,4-bis[4-(p-chlorophenyl)- 4-hydroxypiperidino]butyrophenone in haloperidol. (2/98)
A chromatographic and densitometic method for identification and quantitative determination of 4,4-bis[4-(p-chlorophenyl)-4-hydroxypiperidino]butyrophenone as an impurity in haloperidol pharmaceutical has been developed. The HPTLC plates and chloroform-methanol-ammonium hydroxide 25% (90:9:1) were used for chromatographic separation as stationary and mobile phases respectively. Detection has been carried out in UV at lambda = 350 nm. The determination could be made directly without preliminary component separation by extraction. Based on the statistical analysis of obtained results, it was found that the new method is accurate and repeatable. (+info)Anaesthetic agents inhibit gastrin-stimulated but not basal histamine release from rat stomach ECL cells. (3/98)
By mobilizing histamine in response to gastrin, the ECL cells in the oxyntic mucosa play a key role in the control of the parietal cells and hence of gastric acid secretion. General anaesthesia suppresses basal and gastrin- and histamine-stimulated acid secretion. The present study examines if the effect of anaesthesia on basal and gastrin-stimulated acid secretion is associated with suppressed ECL-cell histamine secretion. A microdialysis probe was implanted in the submucosa of the ventral aspect of the acid-producing part of the stomach (32 rats). Three days later, ECL-cell histamine mobilization was monitored 2 h before and 4 h after the start of intravenous infusion of gastrin (5 nmol kg(-1) h(-1)). The rats were either conscious or anaesthetized. Four commonly used anaesthetic agents were given 1 h before the start of the experiments by intraperitoneal injection: chloral hydrate (300 mg kg(-1)), pentobarbitone (40 mg kg(-1)), urethane (1.5 g kg(-1)) and a mixture of fluanisone/fentanyl/midazolam (15/0.5/7.5 mg kg(-1)). In a parallel series of experiments, basal- and gastrin-induced acid secretion was monitored in six conscious and 25 anaesthetized (see above) chronic gastric fistula rats. All anaesthetic agents lowered gastrin-stimulated acid secretion; also the basal acid output was reduced (fluanisone/fentanyl/midazolam was an exception). Anaesthesia reduced gastrin-stimulated but not basal histamine release by 55 - 80%. The reduction in gastrin-induced acid response (70 - 95%) was strongly correlated to the reduction in gastrin-induced histamine mobilization. The correlation is in line with the view that the reduced acid response to gastrin reflects impaired histamine mobilization. Rat stomach ECL cells were purified by counter-flow elutriation. Gastrin-evoked histamine mobilization from the isolated ECL cells was determined in the absence or presence of anaesthetic agents in the medium. With the exception of urethane, they inhibited gastrin-evoked histamine secretion dose-dependently, indicating a direct effect on the ECL cells. Anaesthetized rats are widely used to study acid secretion and ECL-cell histamine release. The present results illustrate the short-comings of such an approach in that a number of anaesthetic agents were found to impair not only acid secretion but also the secretion of ECL-cell histamine - some acting in a direct manner. (+info)Cardiovascular effects of endothelin-1 and endothelin antagonists in conscious, hypertensive ((mRen-2)27) rats. (4/98)
SB 209670 is a potent antagonist of the vasoconstrictor (ET(A)- and ET(B)-receptor-mediated) and vasodilator (ET(B)-receptor-mediated) effects of endothelin, whereas SB 234551 is relatively selective for the constrictor (ET(A)-receptor-mediated) effects. Since we had previously found SB 209670 exerted antihypertensive, vasodilator effects in conscious, heterozygous, transgenic ((mRen-2)27) (abbreviated to TG) rats, here we compared the two antagonists in that model, and assessed their chronic effects on responses to exogenous endothelin-1. We did this to test our global hypothesis, namely, that SB 209670, but not SB 234551, would cause inhibition of the depressor effects of exogenous endothelin-1 in vivo, and that this differential effect would be associated with a more marked antihypertensive action of SB 234551 in TG rats. SB 209670 and SB 234551 (infused for 50 h) exerted similar, sustained, antihypertensive effects in TG rats. The antihypertensive effects of the antagonists occurred at times when the pressor effects of exogenous endothelin-1 were not significantly inhibited. Furthermore, SB 234551 did not exert a greater antihypertensive effect than SB 209670 at a time (i.e., 2 - 4 h) when the depressor effects of endothelin-1 were abolished by the latter, but not by the former (although this differential action was lost after 24 h infusion). The results caused us to reject the hypothesis that selective antagonism of the vasoconstrictor effects of endothelin-1 would result in SB 234551 exerting a greater antihypertensive effect than SB 209670 in TG rats. (+info)A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine. (5/98)
Small intestinal microsomes of cynomolgus monkeys were found to catalyze hydroxylation and dealkylation of an H(1)-antihistamine prodrug, ebastine. To identify the main enzyme responsible for ebastine hydroxylation, which has been hitherto unknown, we purified two cytochrome P450 isoforms, named P450 MI-2 and P450 MI-3, from the intestinal microsomes on the basis of the hydroxylation activity. P450 MI-2 and P450 MI-3 showed the respective apparent molecular weights of 56,000 and 53,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The internal amino acid sequence of P450 MI-2 had high similarity with those of human CYP4F2, CYP4F3, and CYP4F8. The first 27 amino acid residues of P450 MI-3 were highly homologous with those of monkey CYP3A8 and human CYP3A4/5/7. Furthermore, P450 MI-2 and P450 MI-3 were recognized by anti-CYP4F and anti-CYP3A antibodies, respectively, in immunoblot analysis and catalyzed leukotriene B(4) omega-hydroxylation and testosterone 6beta-hydroxylation, which are known to be mediated by CYP4F and CYP3A, respectively. Although both enzymes had ebastine hydroxylation activity, the V(max) value of P450 MI-2 was much higher than that of P450 MI-3 (37.0 versus 0.406 nmol/min/nmol of P450), and the former K(M) (5.1 microM) was smaller than the latter K(M) (10 microM). Anti-CYP4F antibody inhibited the hydroxylation in small intestinal microsomes strongly (70%), but anti-CYP3A antibody did not. These results indicate that P450 MI-2 belongs to the CYP4F subfamily and is mainly responsible for hydroxylation of ebastine in monkey small intestinal microsomes. This suggests that the small intestinal CYP4F enzyme, P450 MI-2, can play an important role in the metabolism of drugs given orally. (+info)Gene replacement analysis of the butyrolactone autoregulator receptor (FarA) reveals that FarA acts as a Novel regulator in secondary metabolism of Streptomyces lavendulae FRI-5. (6/98)
IM-2 [(2R,3R,1'R)-2-1'-hydroxybutyl-3-hydroxymethyl gamma-butanolide] is a gamma-butyrolactone autoregulator which, in Streptomyces lavendulae FRI-5, switches off the production of D-cycloserine but switches on the production of a blue pigment and several nucleoside antibiotics. To clarify the in vivo function of an IM-2-specific receptor (FarA) in the IM-2 signaling cascade of S. lavendulae FRI-5, a farA deletion mutant was constructed by means of homologous recombination. On several solid media, no significant difference in morphology was observed between the wild-type strain and the farA mutant (strain K104), which demonstrated that the IM-2-FarA system does not participate in the morphological control of S. lavendulae FRI-5. In liquid media, the farA mutant overproduced nucleoside antibiotics and produced blue pigment earlier than did the wild-type strain, suggesting that the FarA protein acts primarily as a negative regulator on the biosynthesis of these compounds in the absence of IM-2. However, contrary to the IM-2-dependent suppression of D-cycloserine production in the wild-type strain, overproduction of D-cycloserine was observed in the farA mutant, indicating for the first time that the presence of both IM-2 and intact FarA are necessary for the suppression of D-cycloserine biosynthesis. (+info)Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. (7/98)
AIMS: The objective of this study was to compare the effects of high doses of ebastine with terfenadine and placebo on QTc. METHODS: Thirty-two subjects were randomly assigned to four treatments (ebastine 60 mg x day(-1), ebastine 100 mg x day(-1), terfenadine 360 mg x day(-1), placebo) administered for 7 days. Serial ECGs were performed at baseline and day 7 of each period. QT interval was analysed using both Bazett (QTcB) and Fridericia (QTcF) corrections. RESULTS: Ebastine 60 mg (+ 3.7 ms) did not cause a statistically significant change in QTcB compared with placebo (+ 1.4 ms). The mean QTcB for ebastine 100 mg was increased by + 10.3 ms which was significantly greater than placebo but was significantly less (P < 0.05) than with terfenadine 360 mg (+ 18.0 ms). There were no statistically significant differences in QTcF between ebastine 60 mg (-3.2 ms) or ebastine 100 mg (1.5 ms) and placebo (-2.1 ms); although terfenadine caused a 14.1 ms increase which was significantly different from the other three treatments. The increase in QTcB with ebastine most likely resulted from overcorrection of the small drug-induced increase in heart rate. CONCLUSIONS: Ebastine at doses up to five times the recommended therapeutic dose did not cause clinically relevant changes in QTc interval. (+info)Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers. (8/98)
The transport characteristics of a selective peripheral H1 receptor antagonist, ebastine, a substrate for cytochrome P450 3A4, and its three major metabolites, i.e., the hydroxy metabolite of ebastine (M-OH), the pharmacologically active metabolite carebastine (Car), and the desbutyrophenone metabolite (des-BP), were studied in cultured human intestinal Caco-2 cells expressing a drug efflux pump, P-glycoprotein (P-gp), on the apical membrane. The polarized transport of [3H]cyclosporin A (CyA), mediated by P-gp in the basolateral to apical direction across the Caco-2 cell monolayers, was affected by the presence of ebastine in a concentration-dependent manner and significant inhibition was observed at high concentrations (>50 microM). M-OH (300 microM) also significantly inhibited whereas Car and des-BP did not. Although no marked polarized transport of [14C]ebastine in a secretory direction was observed in the Caco-2 systems, the flux in the basolateral to apical direction was slightly higher than that in the opposite direction at concentrations less than 30 microm. [14C]Ebastine (2 microM) uptake from the apical side was significantly increased in the presence of an excess of cold CyA, suggesting that the efflux process mediated by P-gp may be involved in the ebastine uptake by Caco-2 cells. Collectively, these results indicate that ebastine (and presumably M-OH) is transported via P-gp in Caco-2 cells, however, the affinity for P-gp is very low. It is unlikely that the secretory transport of ebastine mediated by P-gp will dramatically affect overall intestinal absorption in vivo because efficient passive diffusion of this drug should occur due to its high lipophilicity. However, it may be advantageous for its efficient first-pass metabolism. (+info)
How many words can made out of Butyrophenones | Anagram Solver
Haloperidol (Norodol)
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Haloperidol Lactate
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Antidyskinetics, Antipsychotics, Antiemetics, Butyrophenones, Dopamine Antagonists, ...
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Antidyskinetics, Antipsychotics, Antiemetics, Butyrophenones, Dopamine Antagonists, ATC:N05AD01
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Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of...
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Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics<...
Ebastine - Wikipedia
Efficacy of ebastine for treatment of pruritic skin disease: Patient assessment with a self-administered questionnaire<...
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Azaperone
Title index
Antipsychotic Linked to Rare, Potentially Fatal Skin Reaction - MPR
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Metomidate
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Parkinson's disease
Drugs include but are not limited to: Phenothiazines (chlorpromazine, promazine, etc.) Butyrophenones (haloperidol, benperidol ...
Postoperative nausea and vomiting
Butyrophenones: Typically administered as a single injection at the end of surgery. Adverse effects include prolongation of the ...
Leonard Jan Le Vann
Le Vann, L. J. (1968). A new butyrophenone: Trifluperidol. A psychiatric evaluation in a pediatric setting Canadian Psychiatric ...
Trifluperidol
... is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of ... Gallant DM, Bishop MP, Timmons E, Steele CA (November 1963). "Trifluperidol: a butyrophenone derivative". The American Journal ...
Moperone
... (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class. Gross, H; Kaltenbäck, E (1969 ... "The clinical position of moperone among the butyrophenones". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry. 23 ( ...
Valerophenone
Acetophenone Butyrophenone Propiophenone Milstein, D.; Stille, J. K. (1978). "A general, selective, and facile method for ...
Bromperidol
... (marketed as Bromidol, Bromodol) is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as ... Dubinsky B, McGuire JL, Niemegeers CJ, Janssen PA, Weintraub HS, McKenzie BE (1982). "Bromperidol, a new butyrophenone ... Pöldinger W, Bures E, Haage H (1977). "Clinical study with bromperidol, a new butyrophenone derivative". International ...
Lenperone
... (Elanone-V) is a typical antipsychotic of the butyrophenone chemical class. It was first reported as an emetic in ... FR 2227868, "Antiemetic compositions containing piperidine derivatives" Table 1. Marketed butyrophenones with approval status ... "Treatment of Acute Schizophrenia with a New Butyrophenone-Lenperone". Journal of Clinical Pharmacology. 15 (2-3): 187-90. doi: ...
Methamphetamine
... treatment with a benzodiazepine versus a butyrophenone". Eur. J. Emerg. Med. 4 (3): 130-135. doi:10.1097/00063110-199709000- ...
Aceperone
... is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen ...
Carpipramine
It is structurally related to both tricyclics like imipramine and butyrophenones like haloperidol. Clocapramine Mosapramine ...
Substantia nigra
These antagonists include first generation (typical) antipsychotics such as butyrophenones, phenothiazines, and thioxanthenes. ...
Neuroleptanalgesic
Iorio, M. A.; Paszkowska Reymer, T.; Frigeni, V. (1987). "Combined analgesic/neuroleptic activity in N-butyrophenone prodine- ...
Estradiol undecylate
Benperidol or butyrophenone and the antiandrogen cyproterone acetate also used. Kennedy, BJ (April 1967). "Effect of massive ...
Estradiol (medication)
Benperidol or butyrophenone and the antiandrogen cyproterone acetate also used. "[email protected]: FDA Approved Drug Products". United ...
Typical antipsychotic
Another prominent grouping of antipsychotics are the butyrophenones, an example of which is haloperidol. The newer, second- ...
Actinometer
Organic actinometers like butyrophenone or piperylene are analysed by gas chromatography. Other actinometers are more specific ...
Dopamine hypothesis of schizophrenia
This observation was subsequently extended to other antipsychotic drug classes, such as butyrophenones including haloperidol. ...
Fluanisone
... is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of ...
Hyperprolactinaemia
These drugs include the typical antipsychotics: phenothiazines such as chlorpromazine (Thorazine), and butyrophenones such as ...
Domperidone
... is a benzimidazole derivative and is structurally related to butyrophenone neuroleptics like haloperidol. 1974 - ... Domperidone, a benzimidazole derivative, is structurally related to the butyrophenone tranquilizers (eg, haloperidol (Haldol, ...
Pleurothotonus
K. Ekbom, H. Lindholm and L. Ljungerberg, New dystonic syndrome associated with butyrophenone therapy. Z Neurol, 202 (1972), pp ...
Spiperone
... is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use ...
Risperidone
Although not a butyrophenone, it was developed with the structures of benperidol and ketanserin as a basis. It has actions at ...
History of general anesthesia
Janssen synthesized nearly all of the butyrophenone class of antipsychotic agents, beginning with haloperidol (1958) and ...
Neuroleptic malignant syndrome
Individuals using butyrophenones (such as haloperidol and droperidol) or phenothiazines (such as promethazine and ...
Benperidol
... , sold under the trade name Anquil among others, is a drug which is a highly potent butyrophenone derivative. It is ...
Timiperone
... , sold under the brand name Tolopelon, is an antipsychotic of the butyrophenone class which is marketed in Japan. It ...
Clocapramine
1983). "Comparison of efficacy of timiperone, a new butyrophenone derivative, and clocapramine in schizophrenia: a multiclinic ...
Hyperosmia
Before they had been discontinued due to undesirable side effects, butyrophenones or thioridazine hydrochloride, both of which ...
Butyrophenone - Wikipedia
Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various ... Examples of butyrophenone-derived pharmaceuticals include: Haloperidol, the most widely used classical antipsychotic drug in ... Grogan, Charles H.; Rice, Leonard M. (1967). "Ω-Azabicyclic Butyrophenones". Journal of Medicinal Chemistry. 10 (4): 621. doi: ...
Butyrophenone - definition of butyrophenone by The Free Dictionary
butyrophenone synonyms, butyrophenone pronunciation, butyrophenone translation, English dictionary definition of butyrophenone ... butyrophenone. Also found in: Medical, Wikipedia. bu·ty·ro·phe·none. (byo͞o-tĭr′ō-fə-nōn′, byo͞o′tə-rō-). n.. Any of a group of ... Butyrophenone - definition of butyrophenone by The Free Dictionary https://www.thefreedictionary.com/butyrophenone ... Haloperidol, a butyrophenone antipsychotic, is available in generic formulations and as Haldol, Haldol Decanoate, and Haldol ...
Ultrasonic Studies on Butyrophenones and Related Drugs with Iodin...: Ingenta Connect
Ultrasonic Studies on Butyrophenones and Related Drugs with Iodine in Benzene Solutions, Part I ... Butyrophenone und verwandte Stoffe wurden als Donoren gewählt, während als Akzeptor Jod verwendet wurde. Die ... Ultrasonic studies on donor-acceptor systems have been made in benzene solutions at 30 and 40°C. Butyrophenones and related ...
Chemical Database: Butyrophenone, 4\'-fluoro-4-(4-methylpiperidino)-, hydrochloride (EnvironmentalChemistry.com)
This page contains information on the chemical Butyrophenone, 4\-fluoro-4-(4-methylpiperidino)-, hydrochloride including: 13 ... 4-Fluoro-4-(4-methylpiperidino) butyrophenone hydrochloride*Buronil*Butyrophenone, 4-fluoro-4-(4-methylpiperidino)-, ... Butyrophenone, 4-fluoro-4-(4-methylpiperidino)-, hydrochloride. Identifications. *CAS Number: 1622-79-3*Synonyms/Related:*1-(3 ... Chemical Database - Butyrophenone, 4\-fluoro-4-(4-methylpiperidino)-, hydrochloride. EnvironmentalChemistry.com. 1995 - 2018. ...
Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of...
Here we describe a 3D-QSAR study carried out on a series of butyrophenones with affinity for the serotonin-2A receptor, aligned ... Here we describe a 3D-QSAR study carried out on a series of butyrophenones with affinity for the serotonin-2A receptor, aligned ... Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of ...
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5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs.. S Maayani, C W Wilkinson and J S ... 5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs.. S Maayani, C W Wilkinson and J S ... 5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs.. S Maayani, C W Wilkinson and J S ... 5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs. Message Subject (Your Name) has ...
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Azaperone, a butyrophenone possessing high alpha noradrenergic blocking potency, reduces withdrawal body shakes in a dose ... Azaperone, a butyrophenone possessing high alpha noradrenergic blocking potency, reduces withdrawal body shakes in a dose ... Hynes, Martin Dennis III, "EFFECTIVENESS OF BUTYROPHENONES AND RELATED DRUGS IN NARCOTIC WITHDRAWAL IN THE RAT" (1978). Open ... EFFECTIVENESS OF BUTYROPHENONES AND RELATED DRUGS IN NARCOTIC WITHDRAWAL IN THE RAT ...
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Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Haloperidol has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity ...
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Lhalopéridol est un agent psychotrope indiqué pour le traitement de la schizophrénie. Elle exerce également une activité sédative et anti-émétique. Lhalopéridol a des actions à tous les niveaux du système nerveux central du système avant au sous-corticales niveaux-ainsi que sur les systèmes dorganes multiples. Lhalopéridol a antiadrénergiques forts et faibles dactivité anticholinergique périphériques; ganglionnaires action de blocage est relativement légère. Il a également possède antihistaminique légère et de lactivité antisérotonine ...
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Short description: Butyrophenone and thiothixene neuroleptics. *The 2021 edition of ICD-10-CM T43.4X became effective on ... Poisoning by, adverse effect of and underdosing of butyrophenone and thiothixene neuroleptics. 2016 2017 2018 2019 2020 2021 ... T43.4X Poisoning by, adverse effect of and underdosing of butyrophenone and thiothixene neuroleptics ... T43.4 Poisoning by, adverse effect of and underdosing of butyrophenone and thiothixene neuroleptics ...
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Butyrophenones. Potential for extrapyramidal reactions4 5 267 and worsening of symptoms in patients with parkinsonian syndrome ... Concomitant therapy with drugs likely to cause extrapyramidal reactions (e.g., phenothiazines, butyrophenones).4 5 267 ... butyrophenone, or phenothiazine to the regimen or substituting high-dose IV metoclopramide for the 5-HT3 receptor antagonist in ...
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Haloperidol6
- Haloperidol, a butyrophenone antipsychotic, is available in generic formulations and as Haldol, Haldol Decanoate, and Haldol Lactate. (thefreedictionary.com)
- however, high doses of dopamine receptor blockades result in extrapyramidal reactions, disorientation, and sedation, which limit the clinical use of such agents, including phenothiazines and butyrophenones (droperidol and haloperidol) (8). (thefreedictionary.com)
- Haloperidol, a prototype of butyrophenones , is a high-affinity [D. (thefreedictionary.com)
- A butyrophenone with general properties similar to those of haloperidol. (hmdb.ca)
- Formerly known as major tranquillizers , antipsychotic drugs include the phenothiazines (e.g. chlorpromazine), butyrophenones (e.g. haloperidol), and thioxanthenes (e.g. flupentixol). (encyclopedia.com)
- The prototype antipsychotics are the phenothiazines, such as chlorpromazine (Thorazine), and the butyrophenones such as haloperidol (Haldol). (encyclopedia.com)
Phenothiazines4
- The most common drug classes for single-drug incidents were phenothiazines 84, tricyclic antidepressants 83, butyrophenones 74, paraaminophenols 62, benzodiazepines 46, carbamazepines 36, iron compounds 35, methoxybenzamides 27 and xanthines 27. (thefreedictionary.com)
- Anti-emetics The phenothiazines, butyrophenones (such as droperidol) and metoclopramide, have all been known to cause drug induced PD, and can aggravate and intensify the patient's symptoms (Burton et al 2004). (thefreedictionary.com)
- Human studies have shown that the liver poisoned with Amantia phalloides, phenothiazines (antipsychotic drugs) and butyrophenones (antipsychotic drugs), silymarin reduces the hepatic damage. (thefreedictionary.com)
- Included in the major group are phenothiazines , butyrophenones and piperidine compounds. (wisegeek.com)
Droperidol3
- Neurolept anaesthesia was one of the regimens used, which combined droperidol, a butyrophenone acting by blocking D2 receptors, and fentanyl, an opioid. (thefreedictionary.com)
- Selected butyrophenones used after surgery to address postoperative nausea and vomiting include droperidol, which he referred to as "the Bendectin of anesthesiologists. (thefreedictionary.com)
- The butyrophenone derivative droperidol is the most potent in this class and is the most effective drug for severe NVP and hyperemesis gravidarum. (thefreedictionary.com)
Antipsychotics1
- If psychiatry needs a good, immediate fix, it would be in the development and approval of new chemicals that are both better tolerated than the butyrophenones and more affordable than atypical antipsychotics. (thefreedictionary.com)
Dopamine1
- 2 mg/kg PO q12h), a butyrophenone anxiolytic with a dopamine-receptor antagonist effect, commonly used in feather-picking disorders in parrots, was initiated to maintain a calm bird to provide conditions for muscle regeneration. (thefreedictionary.com)
Phenothiazine4
- Phenothiazine, butyrophenone , and other psychotropic medication poisonings in children and adolescents. (thefreedictionary.com)
- In patients experiencing nausea and vomiting despite recommended prophylaxis regimens, ASCO recommends that clinicians consider adding a benzodiazepine (e.g., alprazolam, lorazepam), butyrophenone, or phenothiazine to the regimen or substituting high-dose IV metoclopramide for the 5-HT 3 receptor antagonist in the regimen. (drugs.com)
- An assay strategy for determining a wide range of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines both alone and in combination in blood and plasma is described. (elsevier.com)
- Perrin, John H. / Liquid chromatographic assay of phenothiazine, thioxanthene and butyrophenone neuroleptics and antihistamines in blood and plasma with conventional and radial compression columns and UV and electrochemical detection . (elsevier.com)
Derivatives1
- some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics. (wikipedia.org)
Derivative1
- Benperidol, sold under the trade name Anquil among others, is a drug which is a highly potent butyrophenone derivative. (wikipedia.org)
Neuroleptic3
Receptor2
- Here we describe a 3D-QSAR study carried out on a series of butyrophenones with affinity for the serotonin-2A receptor, aligned by docking into the binding site of a receptor model. (nih.gov)
- 5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs. (aspetjournals.org)
Reduces1
- Azaperone, a butyrophenone possessing high alpha noradrenergic blocking potency, reduces withdrawal body shakes in a dose related manner, while the alpha adrenergic blocker phenoxybenzamine and the beta adrenergic blocker propronalol failed to reduce withdrawal shakes to any significant extent. (uri.edu)
Drugs3
- Ultrasonic Studies on Butyrophenones and Related Drugs with Iodin. (ingentaconnect.com)
- Ultrasonic studies on donor-acceptor systems have been made in benzene solutions at 30 and 40°C. Butyrophenones and related drugs have been chosen as a donor, while iodine has been selected as an acceptor. (ingentaconnect.com)
- Toxicologists are of en faced with developing methods for new drugs and metabolites with little information available in the literature. (springer.com)
Risk1
- Butyrophenones create serious risk of oculogyric crisis and although these dystonic reactions are reversible, they irritate the patient substantially. (thefreedictionary.com)
MABP1
- Buphedrone (2-(methylamino)-1-phenylbutan-1-one, α-methylamino-butyrophenone, MABP) is a positional isomer of mephedrone. (semanticscholar.org)
Droperidol1
- Droperidol, a butyrophenone antipsychotic, has been used for this purpose in several countries. (edu.au)
Class1
- 4-Methylbuphedrone (also known as 4-MeMABP, BZ-6378 and 4-Methyl-α-methylamino-butyrophenone), is a stimulant drug of the cathinone class that has been sold online as a designer drug. (kaiwodun-pharma.org)