A ZINC FINGER MOTIF containing immediate early protein that is closely related to TRISTETRAPROLIN. It interacts with and helps destabilize VASCULAR ENDOTHELIAL GROWTH FACTOR mRNA.
Derivatives of BUTYRIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxypropane structure.
A MADS domain-containing transcription factor that binds to the SERUM RESPONSE ELEMENT in the promoter-enhancer region of many genes. It is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.
A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.

Hypertrophic stimuli augment expression of cMG1/ERF-1, a putative zinc-finger motif transcription factor, in rat cardiomyocytes. (1/13)

We isolated the gene for cMG1/ERF-1, a known putative zinc-finger transcription factor, by differential display of mRNA extracted from cardiomyocytes with and without leukemia inhibitory factor (LIF) stimulation. LIF induced cMG1/ERF-1 mRNA at 15 min, and levels peaked at 10-fold initial levels at 30 min. cMG1/ERF-1 expression was inhibited by AG490 (JAK2 inhibitor) and genistein, but was unaffected by PD98059 or wortmannin. Phenylephrine, angiotensin II and endothelin-1 also induced cMG1/ERF-1 expression. Mechanical stretch in vitro and acute pressure overload in vivo increased cMG1/ERF-1 expression. To our knowledge, this is the first report showing that the cMG1/ERF-1 gene can be induced by various hypertrophic stimuli, and that Janus kinase 2 is involved in this process.  (+info)

Anti-CD20- and B-cell receptor-mediated apoptosis: evidence for shared intracellular signaling pathways. (2/13)

Clinical administration of the anti-CD20 antibody IDEC-C2B8 can induce remission of low-grade B-cell lymphoma. Whereas it has been suggested that the main mechanisms of action are complement-mediated and antibody-dependent cell-mediated cytotoxicity, we demonstrate that monoclonal antibody IDEC-C2B8 is a strong inducer of apoptosis in CD20-positive B-cell lymphoma cell lines reflecting different stages of lymphomagenesis. Thus, CD20-dependent apoptosis was inducible in human surface IgM-positive Burkitt's lymphoma cell lines as well as in more mature surface IgM-negative B-cell lymphoma cell lines carrying the t(14;18) translocation. Furthermore, in Burkitt's lymphoma cell lines, we observed a striking correlation between anti-CD20- and B-cell receptor-mediated apoptosis with regard to sensitivity toward the apoptotic stimuli and the execution of the apoptotic pathway. Thus, induction of anti-CD20- or B-cell receptor-mediated apoptosis involved rapid up-regulation of the proapoptotic protein Bax. In addition, we show similar changes in the mRNA expression level of two early response genes, c-myc and Berg36, as well as activation of the mitogen-activated protein kinase family members p44 (extracellular signal-regulated kinase 1) and p42 (extracellular signal-regulated kinase 2) and activation of activator protein 1 (AP-1) DNA binding activity. These data support our hypothesis that both pathways are mediated in part by the same signal-transducing molecules. These results might help explain the resistance and regression of lymphomas to IDEC-C2B8 and give new insights in the signaling cascade after CD20 ligation.  (+info)

Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. (3/13)

To identify regulators of AU-rich element (ARE)-dependent mRNA turnover we have followed a genetic approach using a mutagenized cell line (slowC) that fails to degrade cytokine mRNA. Accordingly, a GFP reporter construct whose mRNA is under control of the ARE from interleukin-3 gives an increased fluorescence signal in slowC. Here we describe rescue of slowC by a retroviral cDNA library. Flow cytometry allowed us to isolate revertants with reconstituted rapid mRNA decay. The cDNA was identified as butyrate response factor-1 (BRF1), encoding a zinc finger protein homologous to tristetraprolin. Mutant slowC carries frame-shift mutations in both BRF1 alleles, whereas slowB with intermediate decay kinetics is heterozygous. By use of small interfering (si)RNA, independent evidence for an active role of BRF1 in mRNA degradation was obtained. In transiently transfected NIH 3T3 cells, BRF1 accelerated mRNA decay and antagonized the stabilizing effect of PI3-kinase, while mutation of the zinc fingers abolished both function and ARE-binding activity. This approach, which identified BRF1 as an essential regulator of ARE-dependent mRNA decay, should also be applicable to other cis-elements of mRNA turnover.  (+info)

Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. (4/13)

HT1080 cells stably expressing green fluorescent protein (GFP) linked to a 3' terminal AU-rich element (ARE) proved to be a convenient system to study the dynamics of mRNA stability, as changes in mRNA levels are reflected in increased or decreased fluorescence intensity. This study examined whether mRNA stability can be regulated by small interfering RNAs (siRNAs) targeted to AU-binding proteins (AUBPs), which in turn should reveal their intrinsic role as stabilizers or destabilizers of ARE-mRNAs. Indeed, siRNAs targeting HuR or BRF1 decreased or increased fluorescence, respectively. This effect was abolished if cells were treated with both siRNAs, thus indicating antagonistic control of ARE-mRNA stability. Unexpectedly, downregulation of all four AUF1 isoforms by targeting common exons did not affect fluorescence whereas selective downregulation of p40AUF1/p45AUF1 strongly increased fluorescence by stabilizing the GFP-ARE reporter mRNA. This observation was fully confirmed by the finding that only selective reduction of p40AUF1/p45AUF1 induced the production of GM-CSF, an endogenous target of AUF1. These data suggest that the relative levels of individual isoforms, rather than the absolute amount of AUF1, determine the net mRNA stability of ARE-containing transcripts, consistent with the differing ARE-binding capacities of the isoforms.  (+info)

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. (5/13)

In human cells, a critical pathway in gene regulation subjects mRNAs with AU-rich elements (AREs) to rapid decay by a poorly understood process. AREs have been shown to directly activate deadenylation, decapping, or 3'-to-5' exonucleolytic decay. We demonstrate that enzymes involved in all three of these mRNA decay processes, as well as 5'-to-3' exonucleolytic decay, associate with the protein tristetraprolin (TTP) and its homolog BRF-1, which bind AREs and activate mRNA decay. TTP and BRF-1 each contain two activation domains that can activate mRNA decay after fusion to a heterologous RNA-binding protein, and inhibit ARE-mediated mRNA decay when overexpressed. Both activation domains employ trans-acting factors to trigger mRNA decay, and the N-terminal activation domain functions as a binding platform for mRNA decay enzymes. Our data suggest that the TTP protein family functions as a molecular link between ARE-containing mRNAs and the mRNA decay machinery by recruitment of mRNA decay enzymes, and help explain how deadenylation, decapping, and exonucleolytic decay can all be independently activated on ARE-containing mRNAs. This describes a potentially regulated step in activation of mRNA decay.  (+info)

Mitogen-induced expression of the primary response gene cMG1 in a rat intestinal epithelial cell-line (RIE-1). (6/13)

cMG1 is a primary response gene first identified in a rat intestinal epithelial (RIE-1) cell-line [(1990) Oncogene 5, 1081-1083]. A number of mitogens, including epidermal growth factor (EGF), angiotensin II (AII), serum and insulin rapidly induced 2- to 6-fold increases of cMG1 mRNA in RIE-1 cells, while transforming growth factor-beta caused a small reduction. Cyclic AMP-elevating agents blocked the increase of cMG1 mRNA induced by EGF. The AII-stimulated increase of cMG1 mRNA was blocked by the depletion of protein kinase C, whereas the EGF-stimulated increase was not affected, indicating that protein kinase C-dependent and -independent signalling pathways stimulate cMG1 expression.  (+info)

Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. (7/13)

 (+info)

ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. (8/13)

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I'm sorry for any confusion, but "Butyrate Response Factor 1" is not a widely recognized or established medical term or concept in the field of medicine or biomedical research. It seems that this term may be specific to certain areas of scientific research, particularly those related to gut microbiota and metabolism.

Butyrate is a short-chain fatty acid produced by gut bacteria through fermentation of dietary fiber. In some research contexts, Butyrate Response Factor 1 might refer to a protein or gene that responds to butyrate or regulates its effects in the body. However, without more specific information about the scientific study or publication where this term is used, it's difficult to provide an accurate and concise definition.

If you have access to the original source where you encountered this term, I would recommend reviewing the context in which it is used or consulting the authors for clarification.

Butyrates are a type of fatty acid, specifically called short-chain fatty acids (SCFAs), that are produced in the gut through the fermentation of dietary fiber by gut bacteria. The name "butyrate" comes from the Latin word for butter, "butyrum," as butyrate was first isolated from butter.

Butyrates have several important functions in the body. They serve as a primary energy source for colonic cells and play a role in maintaining the health and integrity of the intestinal lining. Additionally, butyrates have been shown to have anti-inflammatory effects, regulate gene expression, and may even help prevent certain types of cancer.

In medical contexts, butyrate supplements are sometimes used to treat conditions such as ulcerative colitis, a type of inflammatory bowel disease (IBD), due to their anti-inflammatory properties and ability to promote gut health. However, more research is needed to fully understand the potential therapeutic uses of butyrates and their long-term effects on human health.

Serum Response Factor (SRF) is a transcription factor that binds to the serum response element (SRE) in the promoter region of many immediate early genes and some cell type-specific genes. SRF plays a crucial role in regulating various cellular processes, including gene expression related to differentiation, proliferation, and survival of cells. It is activated by various signals such as growth factors, cytokines, and mechanical stress, which leads to changes in the actin cytoskeleton and gene transcription. SRF also interacts with other cofactors to modulate its transcriptional activity, contributing to the specificity of gene regulation in different cell types.

Butyric acid is a type of short-chain fatty acid that is naturally produced in the human body through the fermentation of dietary fiber in the colon. Its chemical formula is C4H8O2. It has a distinctive, rancid odor and is used in the production of perfumes, flavorings, and certain types of plasticizers. In addition to its natural occurrence in the human body, butyric acid is also found in some foods such as butter, parmesan cheese, and fermented foods like sauerkraut. It has been studied for its potential health benefits, including its role in gut health, immune function, and cancer prevention.

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene. This gene is a member of the TIS11 ... Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R (November 2004). "Butyrate response factor 1 is regulated by ... This RNA binding protein most likely functions in regulating the response to growth factors. ZFP36L1 can degrade transcripts of ... The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The ...
It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2. TTP binds to AU-rich ... DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D (Dec 1990). "A growth factor-inducible nuclear protein with a novel cysteine/ ... Carballo E, Lai WS, Blackshear PJ (August 1998). "Feedback inhibition of macrophage tumor necrosis factor-alpha production by ... a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in ...
... recombinant human tumour necrotic factor α (rhTNF-α) and Ionomycin. The HLA type for THP-1 is HLA-A*02:01; A*24:02; B*15:11; B* ... Restoration of the response of purified T lymphocytes to Con A. Increased CO2 production on phagocytosis and differentiation ... Positive detection of alpha-naphthyl butyrate esterase and lysozymes Phagocytic physiology (both for latex beads and sensitized ... and recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF), and mature dendritic cells using rhIL-4, ...
... with a role of familial factors being prevalent. Genetic factors account for 40-60% of the risk factors for alcoholism. Similar ... Responses to this test are recorded as yes or no answers, and scored as a number between zero and 28. Drug abuse or dependence ... Primary references involving sodium butyrate: • Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez ... Genetic factors, along with socio-environmental (e.g., psychosocial) factors, have been established as significant contributors ...
Other factors in the GI tract contribution to immune function include enzymes secreted in the saliva and bile. Beneficial ... An autoimmune response is triggered in intestinal cells by digestion of gluten proteins. Ingestion of proteins found in wheat, ... Basically, the butyrate induces the differentiation of Treg cells by enhancing histone H3 acetylation in the promoter and ... Gastric colonization of this bacterium triggers a robust immune response leading to moderate to severe inflammation, known as ...
Inhibition of HDACs downregulates nuclear factor-κB (NF-κB) and the pro-inflammatory tumor necrosis factor (TNF) as well as ... where a perceived foreign substance or cell stimulates an immune response. The end result of this response can vary from ... SCFAs (acetate, butyrate and propionate) are metabolites created by bacteria in the gut, these molecules then inhibit histone ... For example, diarrhea in humans can be caused by a variety of factors, but is often caused by bacteria such as Clostridium ...
Epigenetic markings can be inherited in some cases, and can change in response to environmental stimuli over the course of an ... Type 2 diabetes mellitus (T2DM) has many variations and factors that influence how it affects the body. DNA methylation is a ... sodium butyrate, and VPA, all known histone deacetylase inhibitors. Several studies in the past two years have shown that in ... However, brain-derived neurotrophic factor (BDNF) and the N-methyl-D-aspartate receptors (NMDA) have been identified as crucial ...
... response element binding protein (CREB), and nuclear factor kappa B (NF-κB). ΔFosB is the most significant biomolecular ... Most of the animal research with HDAC inhibitors has been conducted with four drugs: butyrate salts (mainly sodium butyrate), ... The transcription factor delta FosB is increased in the NAc, PFC, dorsal striatum, and VTA following repeated sexual behavior ( ... ΔJunD, a transcription factor, and G9a, a histone methyltransferase, both oppose the function of ΔFosB and inhibit increases in ...
... family is tightly regulated itself by a myriad of factors including transcription factors Sp1 and CCAAT box binding factor (CBF ... One metabolite, butyrate, induces hyperacetylation of the histones around the PDK4 gene. This is associated with a greater ... "PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in ... Other factors, such as insulin, directly downregulate both PDK2 and PDK4 mRNA transcription. This is done through a proposed ...
One of the major risk factors for periodontitis is the disruption of the oral microbiome such that there is an accumulation of ... In CRC patients, a general dysbiosis pattern has been discovered, including a decrease in butyrate-producing bacteria and an ... However, the broad-spectrum antibiotic rifaximin has been shown to have a favorable response in several of the ailments ... Disruptions in the microbiome can allow outside factors or even pathogenic members of the microbiome to take hold in the gut ...
Additional health factors that may skew the composition of the gut microbiota are antibiotics and probiotics. Antibiotics have ... As of 2016, studies with humans measuring changes to gut microbiota in response to stress, or measuring effects of various ... butyrate, and acetate. The history of ideas about a relationship between the gut and the mind dates from the nineteenth century ... Smeets, PA; Erkner, A; de Graaf, C (November 2010). "Cephalic phase responses and appetite". Nutrition Reviews. 68 (11): 643-55 ...
Mechanisms of Stimulus-Response Coupling in Platelets. Advances in Experimental Medicine and Biology. Vol. 192. pp. 265-80. doi ... The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is ... "Entrez Gene: PTAFR platelet-activating factor receptor". Correa-Costa M (Apr 2014). "Activation of platelet-activating factor ... platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article ...
Sodium Butyrate Sodium butyrate treatment slowed neuronal degeneration in Drosophila models. Sodium butyrate treatment also ... a neurotrophic factor important for long-term memory. Expression of CREB, an activity-dependent transcription factor involved ... In addition, the thymus is a key organ in the immune response that is often negatively affected by abnormal miRNA expression ... Sodium butyrate Sodium butyrate is a class I and II HDACi and has been shown to recover learning and memory after 4 weeks, ...
One study specifically identified the transcription factor NF-kB as a target of butyrate to decrease the number of pro- ... "Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease". Gut. 47 (3): 397-403. ... Butyryl-phosphate is then converted into butyrate by using butyrate kinase and in the process, releases ATP. Butyrate plays an ... Butyrate kinase is active within the human colon. To form butyrate, two molecules of acetyl-CoA are combined and reduced to ...
Butyrate has been shown to be a critical mediator of the colonic inflammatory response. It is responsible for about 70% of ... butyrate depletions could be a key factor influencing the pathogenesis of many vasculitic conditions. It is thus essential to ... Sodium butyrate Butyl butyrate Butyryl-CoA Cellulose acetate butyrate (aircraft dope) Estradiol benzoate butyrate Ethyl ... whereas carnivores have butyrate-producing bacterial communities dominated by the butyrate kinase pathway. Butyrate's effects ...
Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells., PLoS ... Chakravortty D , Kato Y , Koide N , Sugiyama T, Kawai M, Fukada, M, Yoshida T, Yokochi T, 1999, Production of tissue factor in ... Chakravortty D , Koide N, Kato Y, Sugiyama T, Mu MM, Yoshida T, Yokochi, T,2000,The inhibitory action of butyrate on ... Dhingra D, Marathe SM, Sharma N, Marathe A, Chakravortty D, 2021, Modelling immune response to Salmonella during typhoid, Int ...
These transcription factors have been shown to play a role in the short-term and long-term adaptive changes in the brain. CREB ... They found unexpected patterns of brain activation in awake rats that were exposed to sodium butyrate, an HDAC inhibitor (or ... The NK1R gene promoter has been associated with enhanced response to cocaine reward, meaning HDAC5 in normal genomes may ... ΔFosB is a cocaine-induced transcription factor that accumulates in the nucleus accumbens (NAc) and acts to repress G9a. When ...
When isolated resistant starch is used to substitute for flour in foods, the glycemic response of that food is reduced. There ... Muir, J. G.; O'Dea, K. (1992). "Measurement of resistant starch: factors affecting the amount of starch escaping digestion in ... The fermentation of resistant starch produces more butyrate than other types of dietary fibers. Studies have shown that ... The fermentation of resistant starch produces short-chain fatty acids, including acetate, propionate, and butyrate and ...
Treg cells downregulate effector T cells, which in turn reduces the inflammatory response in the gut. Butyrate is an energy ... Factors that disrupt the microorganism population of the large intestine include antibiotics, stress, and parasites. Bacteria ... Additionally, butyrate has also been shown to decrease insulin resistance, suggesting gut communities low in butyrate-producing ... such as butyrate and acetate. Diets yielding butyrate and acetate from bacterial fermentation show increased Treg expression. ...
Many laboratories also perform a butyrate esterase test and a beta-lactamase test. Both tests should be positive and can help ... Also, a bactericidal serum antibody has also been developed in response to the diseases caused by M. catarrhalis. Treatment ... Lipooligosaccharide is considered one possible virulence factor. Since the recent recognition of M. catarrhalis as an important ... a sort of subclass-specific IgG antibody response to certain outer membrane proteins may also exist. Therefore, the outer ...
Sodium butyrate is another chemical that inhibits class I HDACs, thus resulting in the ability for transcription factors to ... Thus, this could affect the efficiency and drug response to the anti-HIV therapy. CYP1A1 is a protein that is well known for ... Class II HDACs 5 and 9 inhibit the activity of a factor known as myocyte enhancer factor 2 (MEF2), which unable to bind ... trichostatin A and sodium butyrate are two HDAC inhibitors. Trichostatin A is known for its ability to inhibit class I and II ...
Brain-derived neurotrophic factor (BDNF), another important gene in neural plasticity, has also been shown to have reduced ... Stott RT, Kritsky O, Tsai LH (2021). "Profiling DNA break sites and transcriptional changes in response to contextual fear ... Studies with histone deactylase complex inhibitors like SAHA, toluene, garcinol, trichostatin A and sodium butyrate have shown ... Sui L, Wang Y, Ju LH, Chen M (May 2012). "Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long- ...
Specific risk factors may predict worse outcomes and a higher risk of mortality in people with ulcerative colitis, including: C ... This response to transplantation often causes prolonged diarrhea if the colon is affected. Typical symptoms also include rash. ... It has been shown that N-butyrate helps supply nutrients to this epithelial barrier. Studies have proposed that hydrogen ... Other identified dietary factors that may influence the development and/or relapse of the disease include meat protein and ...
... including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood ... Alclometasone dipropionate, betamethasone dipropionate, betamethasone valerate, clobetasol propionate, clobetasone butyrate, ... transcription factor T-bet). Both genes display some degree of polymorphic variation in humans, which may explain how some ... Patients' response to inhaled corticosteroids has some basis in genetic variations. Two genes of interest are CHRH1 ( ...
Aka interferon response factor binding domain (IBiD) The nuclear receptor coactivator binding domain (NCBD) located at the c- ... Bordonaro M, Lazarova DL (July 2015). "CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer". World ... A number of factors that associate with CBP bind to either the CH1 or CH3 domain, or to both, despite their locations at ... The E2F family of transcription factors are critical for taking a cell from G1 to S phase of the cell cycle. They bind to a ...
For example, transcription factor nerve growth-induced protein A (NGFI-A, also called NAB1) is up-regulated in response to high ... "Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the ... Nr3c1 is a transcription factor that encodes a glucocorticoid receptor (GR) and contains many GR response elements. Npas4 is ... This response differs between short-lived stress exposure and chronic stress exposure. In response to short lived stress, the ...
Factors to which this is attributed are larger consumption, faster digestion and higher feed conversion rate. The type of crop( ... However, the autogamous annual Stylosanthes humilis proved otherwise by adapting in response to changing conditions during an ... such as butyrate) used by intestinal cells for food energy. Forage legumes are of two broad types. Some, like alfalfa, clover, ... Environmental factors that are important in influencing germination are relative humidity and temperature. Two rules apply to ...
Wang F, Wu H, Fan M, Yu R, Zhang Y, Liu J, Zhou X, Cai Y, Huang S, Hu Z, Jin X (March 2020). "Sodium butyrate inhibits ... 3) CATPB and BTI-A-404 are reverse agonists, i.e., they bind to the same site as SCFAs but induce a response opposite to that ... There is a need to define the precise roles of SCFAs, FFAR2, and the other proposed causal factors in these neurological ... Semaan J, El-Hakim S, Ibrahim JN, Safi R, Elnar AA, El Boustany C (July 2020). "Comparative effect of sodium butyrate and ...
... transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and leukemia inhibitory factor (LIF)). The ... Astrocytes - the most common neuroglial brain cells, which contribute to scar formation in response to injury - can be directly ... sodium butyrate (NaB) or Trichostatin A (TSA) could replace VPA, Lithium chloride (LiCl) or lithium carbonate (Li2CO3) could ... However, brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully ...
Sodium butyrate is commonly used as a candidate for mood disorder treatment: studies using it both alone and in co-treatment ... A large variety of nonhistone transcription factors and transcriptional co-regulators are known to be modified by acetylation. ... Recent studies [...] have shown that the estrogen receptor alpha (ERalpha) can be hyperacetylated in response to histone ... Acetylation enhances the activity of some transcription factors such as the tumor suppressor p53 and the erythroid ...
Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene. This gene is a member of the TIS11 ... Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R (November 2004). "Butyrate response factor 1 is regulated by ... This RNA binding protein most likely functions in regulating the response to growth factors. ZFP36L1 can degrade transcripts of ... The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The ...
These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting ... The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate ... Formation of propionate and butyrate by the human colonic microbiota Environ Microbiol. 2017 Jan;19(1):29-41. doi: 10.1111/1462 ... These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting ...
... and butyrate is the preferable energy substrate for colonocytes, regulating local inflammatory responses and inducing apoptosis ... This allowed paired comparisons to be drawn between factors taking into account participant ID. ... Butyrate production which was the highest for HI-MAIZE® and raftilose followed by apple pectin and mixed fibre. Wheat bran ... For example, in contrast to the ,35% baseline change to ASVs in HC in response to HI-MAIZE® and raftilose, strikingly no change ...
Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohns disease. Gut 2000;47:397-403. ... SLC16A1 encoding for the butyrate receptor, the aquaporins AQP3 and AQP8, the trefoil factor TFF1, and those genes encoding for ... Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. ... Another interesting target identified in this study is the SLC16A1 gene encoding for the butyrate receptor. Butyrate is a ...
... butyrate response factor 1), a probable regulatory protein involved in regulating the response to growth factors, and the mouse ... The mouse TTP protein is induced by growth factors. Another protein containing this domain is the human splicing factor U2AF ... Nup475 is a nuclear zinc-binding protein of unknown function that is induced in mammalian cells by growth factor mitogens. ... They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), ...
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens) * Protein Kinase B/Akt phosphorylates BRF1 (Homo ...
The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of ... The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of ... other factors must nevertheless be considered. Recent insight suggests that an altered composition and diversity of gut ... other factors must nevertheless be considered. Recent insight suggests that an altered composition and diversity of gut ...
Li H, Gao Z, Zhang J et al (2012) Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition ... 15] observed that the abundance of butyrate-producing bacteria is associated with a better insulin response during an oral ... Fu X, Liu Z, Zhu C, Mou H, Kong Q (2019) Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria. Crit Rev Food ... Greater abundance of butyrate-producing bacteria was observed in individuals with normal glucose tolerance than the other two ...
We hypothesize that sodium butyrate (butyrate) attenuates inflammatory responses and lipolysis generated by the interaction of ... we investigated the effects of butyrate on the production of tumor necrosis factor alpha (TNF-α), monocyte chemoattractant ... CONCLUSION: Butyrate suppresses inflammatory responses generated by the interaction of adipocytes and macrophages through ... and butyrate significantly reduced them. Butyrate inhibited the phosphorylation of MAPKs, the activity of NF-κB in co-cultured ...
Effects of butyrate on the expression of insulin-like growth factor binding proteins in bovine kidney epithelial cells - (Peer ... Quantification of transcriptome responses of the rumen epithelium to butyrate infusion - (Peer Reviewed Journal) ... Effects of butyrate on the expression of insulin-like growth factor binding proteins in bovine kidney epithelial cells. The ... Quantification of transcriptome responses of the rumen epithelium to butyrate infusion. Gene Regulation and Systems Biology. 6: ...
Interaction of butyrate and polyunsaturated fatty acids modulate apoptotic vs. differentiation response of colon epithelial ... Growth/differentiation factor-15 inhibits differentiation into osteoclasts - A novel factor involved in control of osteoclast ... Response of normal vs. cancer colon cells to short- and long-chain fatty acids. In Response of normal vs. cancer colon cells to ... Interaction of butyrate and polyunsaturated fatty acids modulate apoptotic vs. differentiation response of colon epithelial ...
Indeed, the modulation of the intestinal microbiome enhances immune response of immunotherapies in the anti-cancer response ( ... especially butyrate. For example, butyrate promotes the generation of regulatory T lymphocytes (Tregs) via the FFAR2 receptor ( ... Fluid shifts from the lower into the upper part of the body and might alongside other factors, cause changes in ... Butyrate supplementation increases the secretion of IFNγ by CD8 T lymphocytes (Luu et al., 2018). In humans, it is commonly ...
Basic Helix-Loop-Helix Transcription Factors. *Basic-Leucine Zipper Transcription Factors. *Butyrate Response Factor 1 ... Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in ... "Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Hepatocyte Nuclear Factors" by people in this website by year ...
... of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response. ... 8: Roduit C, Frei R, Ferstl R, Loeliger S, Westermann P, Rhyner C, u. a. High levels of butyrate and propionate in early life ... Letter to Editor in Response to: The Hidden (and Fatty) Side of Vacuum Bell by Tedde M". Journal of Pediatric Surgery 57, Nr. ... Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and ...
In mice studies, oral administration of Flavinofractor plautii was noted to suppress Th2 immune responses. Thus, one may ... These associated to controls and are known butyrate producers, usually associated with a beneficial effect on gut homeostasis. ... Highlighted as well are the associations of the respective ASVs to various factors, as detected by indicator species analysis ( ... F: +43 (0)1 710 22 42-001. E: This email address is being protected from spambots. You need JavaScript enabled to view it.. ...
... the butyrate maybe stronger in vivo due to additional factors compared to in vitro treatment. ... Please note while forming your response, if your article is accepted, you may have the opportunity to make the peer review ... The butyrate-producing E. coli appear to reduce aggregates in the control strain as much or more than they reduce it in the ... 2-Can the authors elaborate more on the effect of butyrate? It would be a good addition to the manuscript at least to show if ...
Zelllinie THP 1 human Leukemic monocyte, 88081201; Synonyms: O-THP-1 Cells,THP-1 Macrophages,THP-1 Monocytes,THP1 Cells,THPI ... Cells,Tohoku Hospital Pediatrics-1 Cells; find -CB_88081201 MSDS, related peer-reviewed papers, technical documents, similar ... These cells also stain positive for α-napthhyl butyrate esterase, produce lysozymes and are phagocytic (both latex beads and ... the effect of lipopolysaccharide-mediated inflammatory response in murine versus human cell lines ...
Arterial calcifications and stroke share many risk factors, and in fact, history of ischemic stroke is one of the risk factors ... Butyrate is one of the better studied of these metabolites, particularly in the context of cognitive function. Butyrate ... All too much of the metabolic response to stress, and items such as circadian rhythms that have an impact on that response, ... The underlying mechanisms still remain to be defined but could include common risk factors, tumor-secreted factors, or effects ...
Butyrate Response Factor 1. Fragile X Mental Retardation Protein. Gene Products, rev ...
Inadequate butyrate levels in the lower intestine have been suggested as a contributing factor for the disease. This might be ... Some parasites are able to reduce the immune response of the intestine, an adaptation that helps the parasite colonize the ... The colon utilizes butyrate from the contents of the intestine as an energy source. The amount of butyrate available decreases ... Both helminthic therapy and fecal bacteriotherapy induce a characteristic Th2 white cell response in the diseased areas, which ...
Cox proportional hazards regression showed that the fecal concentrations of acetate, butyrate, and propionate were, together, ... while the site-dependence of the responses illustrate the challenges facing reproducibility and interpretation in microbiome ... while the concentrations of acetate and butyrate reflected a dependence on study site. Across all samples, Muribaculaceae ... At all three study sites, the bloom of a single bacterial taxon was the most obvious response to acarbose treatment. The ...
Therefore, the repellent response to these stress conditions may be an important factor for the survival of L. agilis in the ... L. agilis BKN88 exhibited repellent responses to organic acids, lactate, acetate, and butyrate. Organic acids are the main ... Chemotactic responses to STC, SDC, and SC were attenuated in the Δmcp1 and Δmcp2 mutants. Meanwhile, chemotactic responses to ... To examine these bidirectional responses of L. agilis to pH, the chemotactic responses of L. agilis to the agar with pH values ...
... summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and ... Besides other factors, cytokines released in response to DNA damage give rise to the senescence-associated secretory phenotype ... Besides immunomodulatory properties, butyrate is a source of energy for intestinal epithelial cells and also helps maintain the ... M. Murata, H. Nakasone, J. Kanda et al., "Clinical factors predicting the response of acute graft-versus-host disease to ...
Basic-Leucine Zipper Transcription Factors [D12.776.260.108] * Butyrate Response Factor 1 [D12.776.260.114] ... Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103] * ... POU Domain Factors [D12.776.930.710] * Pre-B-Cell Leukemia ... Nuclear Receptor Subfamily 1, Group D, Member 1 [D12.776.260.643.080] * Nuclear Receptor Subfamily 1, Group F, Member 1 [ ... Nuclear Receptor Subfamily 1, Group F, Member 2 [D12.776.260.643.110] * Nuclear Receptor Subfamily 1, Group F, Member 3 [ ...
Discover the top 10 reasons why you should consider supplementing butyrate for improved gut and total body health. ... Butyrate is one of the ultimate players in the gut-brain connection. It increases brain-derived neurotrophic factor (BDNF), a ... 3. Promote a Healthy Inflammation Response in the Gut*. The lining of your gut is also responsible for maintaining proper ... Check out BodyBios Butyrate Supplements. Try either our Calcium/Magnesium Butyrate and Sodium Butyrate formulations by ...
Butyrate Response Factor 1 [D12.776.157.725.030] * Fragile X Mental Retardation Protein [D12.776.157.725.061] ... Integration Host Factors [D12.776.097.513] * Host Factor 1 Protein [D12.776.097.513.500] ... Host Factor 1 Protein Preferred Term Term UI T472566. Date12/06/2001. LexicalTag NON. ThesaurusID NLM (2003). ... Host Factor 1 Protein Preferred Concept UI. M0089787. Registry Number. 0. Scope Note. An integration host factor that was ...
... including taxa with fiber-degrading and butyrate-producing capabilities. Most importantly, there was little change in the ... suggesting that this is not due to microbial factors such as lack of butyrate [26,27]. The gut harbors many intestinal hormones ... Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant ... butyrate has been found not to affect muc2 expression unless glucose is restricted [57], and therefore the loss of butyrate ...
Basic-Leucine Zipper Transcription Factors * Butyrate Response Factor 1 [D12.776.260.114] Butyrate Response Factor 1 ... Basic-Leucine Zipper Transcription Factors [D12.776.260.108] ... Paired Box Transcription Factors [D12.776.260.645] Paired Box ... Early Growth Response Transcription Factors [D12.776.260.158] Early Growth Response Transcription Factors ... Early Growth Response Transcription Factors [D12.776.930.213] Early Growth Response Transcription Factors ...
Basic Helix-Loop-Helix Transcription Factors. *Basic-Leucine Zipper Transcription Factors. *Butyrate Response Factor 1 ... "G-Box Binding Factors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus ... This graph shows the total number of publications written about "G-Box Binding Factors" by people in this website by year, and ...
Invitrogen Anti-ZO-1 Monoclonal (ZO1-1A12), Catalog # 33-9100. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and ... Effects of butyrate- on ruminal Ca2+ transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels. ... bicellular tight junction assembly cellular response to calcium ion blastocyst formation cell-cell junction assembly sensory ... Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the ...

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