Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Quaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Muscle Cramp: A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)Scopolamine Hydrobromide: An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Muscarinic Antagonists: Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.Postoperative Nausea and Vomiting: Emesis and queasiness occurring after anesthesia.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Antiemetics: Drugs used to prevent NAUSEA or VOMITING.Pneumonia, Aspiration: A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Canrenone: A synthetic pregnadiene compound with anti-aldosterone activity.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Anesthesia, Conduction: Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Anesthesia, General: Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)Anesthesia, Intravenous: Process of administering an anesthetic through injection directly into the bloodstream.Colic: A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Renal Colic: A severe intermittent and spasmodic pain in the lower back radiating to the groin, scrotum, and labia which is most commonly caused by a kidney stone (RENAL CALCULUS) passing through the URETER or by other urinary track blockage. It is often associated with nausea, vomiting, fever, restlessness, dull pain, frequent urination, and HEMATURIA.Education, Veterinary: Use for general articles concerning veterinary medical education.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Digestive System: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Ruminants: A suborder of the order ARTIODACTYLA whose members have the distinguishing feature of a four-chambered stomach, including the capacious RUMEN. Horns or antlers are usually present, at least in males.Drug Discovery: The process of finding chemicals for potential therapeutic use.Illusions: The misinterpretation of a real external, sensory experience.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Radio Frequency Identification Device: Machine readable patient or equipment identification device using radio frequency from 125 kHz to 5.8 Ghz.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Electromagnetic Radiation: Waves of oscillating electric and MAGNETIC FIELDS which move at right angles to each other and outward from the source.IndiaBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Industry: Any enterprise centered on the processing, assembly, production, or marketing of a line of products, services, commodities, or merchandise, in a particular field often named after its principal product. Examples include the automobile, fishing, music, publishing, insurance, and textile industries.Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Science: The study of natural phenomena by observation, measurement, and experimentation.Burial: The act or ceremony of putting a corpse into the ground or a vault, or into the sea; or the inurnment of CREMAINS.Equipment and Supplies: Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Equipment Safety: Freedom of equipment from actual or potential hazards.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Medical Device Legislation: Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.

Effects of beta-adrenergic stimulation on the acutely obstructed ureter in dogs. (1/44)

The objective of the present study was to evaluate the effects of a selective beta(3)-adrenoceptor agonist, (R, R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1, 3-benzodioxole-2,2-dicarboxylate (CL 316243), on the acutely obstructed ureter in anesthetized dogs. After a complete ureteral obstruction produced by the inflation of a balloon catheter placed within the left lower ureter, the intraluminal ureteral pressure gradually rose to reach a plateau of approximately 52.5 mm Hg. Intravenous administration of isoproterenol (a nonselective beta-adrenoceptor agonist; 10 microg/kg) and CL 316243 (1 microg/kg) significantly decreased this elevated ureteral pressure (by 74.1 and 77.2%, respectively), with the reduction more sustained with CL 316243 than with isoproterenol. In addition, under both isoproterenol and CL 316243, urine flow (which had been interrupted by the balloon) was resumed, resulting in further sustained decreases in ureteral pressure. The mean blood pressure decreased and heart rate increased after the administration of both drugs, but these changes were greater in the isoproterenol group than in the CL 316243 group. In contrast, i.v. administration of butylscopolamine (an anticholinergic agent; 1000 microg/kg) had no evident effects on ureteral pressure or on urine flow. The increase in left kidney weight seen after ureteral obstruction was suppressed by CL 316243. We conclude that the selective beta(3)-adrenoceptor agonist tested appears to be more useful than isoproterenol for reducing ureteral pressure above the obstructed site and for promoting ureteral relaxation and increasing urine flow around the point of obstruction in dogs.  (+info)

The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang. (2/44)

The influence of synthetic drugs prescribed for peptic ulcer on the pharmacokinetic fate of glycyrrhizin (GL) from Shaoyao-Gancao-tang (SGT, a traditional Chinese formulation, Shakuyaku-Kanzo-to in Japanese) was investigated in rats. Co-administration of histamine H2-receptor antagonist (cimetidine) and anticholinergic drug (scopolamine butyl bromide) with SGT didn't influence the area under the plasma concentration-time curves (AUC) of glycyrrhetic acid (GA), an active metabolite derived from GL in SGT. The AUC of GA from SGT were significantly reduced by co-administration of synthetic drugs commonly used for peptic ulcer in a triple therapy (OAM), a combination of a proton pump inhibitor (omeprazole) and two antibiotics (amoxicillin and metronidazole). We found that the reduction of AUC in OAM treatment was due to the antibacterial effect of amoxicillin and metronidazole on intestinal bacteria in rat which lead to the decrease of GL-hydrolysis activity. The present study suggests that it may not be a proper way to use triple therapy containing antibiotics simultaneously with SGT for healing of chronic ulcers.  (+info)

Safety and efficacy of glucagon as a premedication for upper gastrointestinal endoscopy--a comparative study with butyl scopolamine bromide. (3/44)

BACKGROUND: Glucagon inhibits digestive motility and is used for endoscopic premedication; however, its effect on cardiopulmonary function during endoscopy has not yet been fully investigated. AIM: To clarify the efficacy and safety of glucagon compared with butyl scopolamine bromide as upper gastrointestinal endoscopy premedication. METHODS: Two hundred and forty consecutive patients over 40 years of age, referred for upper gastrointestinal endoscopy, without any complications, were studied. These patients were randomly premedicated with butyl scopolamine bromide (SC group) or glucagon (G group). Time course changes in blood pressure, arterial oxygen saturation, heart rate and the number of retching episodes during endoscopy were examined. The efficacy of glucose tablets after upper gastrointestinal endoscopy to prevent hypoglycaemia caused by glucagon was evaluated. Cardiopulmonary parameters were also examined in 77 complicated patients with glucagon premedication (GC group). RESULTS: A continuous increase in heart rate during upper gastrointestinal endoscopy was observed in the SC group, but not in the G and GC groups. Blood pressure, arterial oxygen saturation and number of retching episodes were not different between the groups. Hypoglycaemia-related symptoms were frequent in the G group without glucose tablets, but were prevented by the administration of glucose. CONCLUSIONS: Glucagon has a weaker effect on cardiopulmonary function during upper gastrointestinal endoscopy than butyl scopolamine bromide. Glucose administration prevents hypoglycaemia-related symptoms caused by glucagon.  (+info)

Identification of the biomechanical factors associated with the perception of distension in the human esophagus. (4/44)

Current techniques used to investigate the mechanisms responsible for the sensory responses to distension of the human esophagus provide limited information because the degree of circumferential stretch required to determine tension can only be inferred. We used impedance planimetry to measure the cross-sectional area during esophageal distension to ascertain the degree of stretch and tension that initiated motor and sensory responses. Hyoscine-N-butyl bromide (HBB), a cholinergic muscarinic receptor blocker, was also used to alter esophageal tension during distension. Motor activity was initiated at a lower degree of stretch and tension than that which initiated sensory awareness; both increased directly with increasing distension. HBB reduced both esophageal motility and tension during distension without altering the relationship between sensation intensity and cross-sectional area. Esophageal stretch, rather than tension, thus appears to be the major factor influencing sensory responses to esophageal distension.  (+info)

Sensory and biomechanical responses to ramp-controlled distension of the human duodenum. (5/44)

The aim of this study was to develop a new method for investigation of the relationship among the mechanical stimulus, the biomechanical properties, and the visceral perception evoked by volume/ramp-controlled distension in the human duodenum in vivo. An impedance planimetric probe for balloon distension was placed in the third part of the duodenum in seven healthy volunteers. Distension of the duodenum was done at infusion rates of 10, 25, and 50 ml/min. The pump was reversed when level 7 was reached on a visual analog scale ranging from 0 to 10. Distensions were done with and without the administration of the antimuscarinic drug butylscopolamine. The total circumferential tension (T(total)) and the passive circumferential tension (T(passive)) were determined from the distension tests without and with the administration of butylscopolamine, respectively. T(total) and T(passive) showed an exponential behavior as a function of strain (a measure of deformation). The active circumferential tension (T(active)) was computed as T(total)-T(passive) and showed a bell-shaped behavior as a function of strain. At low distension intensities, the intensity of sensation at 10 ml/min was significantly higher than that obtained at 25 and 50 ml/min. The coefficient of variation at the pain threshold for circumferential strain (average 4.34) was closer to zero compared with those for volume (8.72), pressure (31.22), and circumferential tension (31.55). This suggests that the mechanoreceptors in the gastrointestinal wall depend primarily on circumferential strain. The stimulus-response functions provided evidence for the existence of low- and high-threshold mechanoreceptors in the human duodenum. Furthermore, the data suggest that high-threshold receptors are nonadapting.  (+info)

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Buscopan (hyoscine butylbromide) in abdominal colic. (6/44)

A short cut review was carried out to establish whether buscopan (hyoscine butylbromide) is better than analgesics at controlling pain in abdominal colic. A total of 31 papers were found using the reported search, of which none presented any evidence to answer the clinical question. It is concluded that there is no evidence available to answer this question. Further research is needed.  (+info)

Effect of diazepam and hyoscine butylbromide on response to secretin and cholecystokinin-pancreozymin in man. (7/44)

Ten subjects received secretin and cholecystokinin or, in duplicate tests, the two hormones together with either diazepam or diazepam plus hyoscine butylbromide in order to determine whether these drugs, which are often used during retrograde endoscopic cannulation of the pancreatic duct, affect pancreatic and biliary secretion in response to the hormones. Diazepam with hyoscine butylbromide reduced the secretion of trypsin into the duodenum and delayed the appearance of both trypsin and bilirubin in duodenal aspirate. These effects must be taken into account when interpreting pancreatic and biliary responses measured during direct cannulation of the pancreatic duct.  (+info)

Assessment of the anticholinergic effect of the new antihistamine mizolastine in healthy subjects. (8/44)

1. Twelve healthy subjects were enrolled in a double-blind placebo controlled cross-over study in order to assess the possible anticholinergic effects of four doses of a new antihistamine compound, mizolastine, compared with hyoscine butylbromide (HBB) used as a reference anticholinergic drug. 2. Although mizolastine, a potent and selective H1-receptor blocker has no affinity for muscarinic receptors and does not antagonize the effects of carbachol in rodents, a study was initiated to investigate its effects on various effectors possessing muscarinic receptors (eye, heart, sweat gland, salivary gland). 3. HBB (40 mg, s.c.) impaired accommodation, decreased salivary flow and inhibited cardiac sinus arrhythmia. Pupil diameter and maximum constriction speed, carbachol-induced skin sweating and Valsalva ratio were unaffected. 4. Mizolastine (5, 10, 20, 40 mg p.o.) did not affect any parameter at any time point, demonstrating a lack of anticholinergic effect.  (+info)

Results 132 patients were recruited to the trial. At 30 min, all analgesic combinations produced significant similar levels of pain relief. At 60 min after administration of the trial medication, mean reductions in pain scores for patients receiving paracetamol only were significantly greater than those receiving paracetamol + hyoscine butylbromide (ANCOVA model, p=0.0180). No relationship was seen between treatment arm and the need for rescue analgesia (χ2, p value=0.846).. ...
Product name: Buscopan. Active substance: Butylscopolamine. Used to: BUTYLSCOLOPAMINE(other names of active ingridient - scopolamine butylbromide, butylhyoscine and hyoscine butylbromide) is an anticholinergic medicine. Butylscopolamine has many effects in the body including decreasing the secretion of fluids, slowing the stomach and intestines, and dilation of the pupils. Butylscopolamine is used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery. Butylscopolamine may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis, and other conditions.. Also Known As: Buscopan. Manufacturer: German Remedies Ltd. Where to buy: Visit our store. Payment method: Visa. Delivery Time: 5-7 business days by Courier Service or 10-21 business days by Standard International Airmail. Discount program: Worldwide Shipping Bargain Prices Get the best quality drugs at our online pharmacy. Discreet ...
284) given rectally (as a solution), buccal midazolam (p. 286), or paraldehyde (p. 286) as an enema may be appropriate. For the use of midazolam by subcutaneous infusion using a continuous infusion device, see p. 28. g. hyoscine), antidepressants and some antiemetics; if possible, an alternative preparation should be considered. Dry mouth may be relieved by good mouth care and measures such as sucking ice or pineapple chunks, chewing gum, or the use of artificial saliva (p. 661); dry mouth associated with candidiasis can be treated by oral preparations of nystatin (p. Hyoscine butylbromide (p. 55) is effective in bowel colic, is less sedative than hyoscine hydrobromide, but is not always adequate for the control of respiratory secretions; it is given by subcutaneous infusion (important: hyoscine butylbromide must not be confused with hyoscine hydrobromide, above). g. owing to uraemia) antiepileptic medication should not be stopped. Midazolam (p. 286) is the benzodiazepine antiepileptic of choice ...
Objective: to establish the safety and efficacy of hyoscine-N-butylbromide (Buscopan®) in accelerating labour in first time parturients. Design: a randomised, double-blinded, placebo-controlled clinical trial. Setting: the antenatal clinic and maternity unit of the Aga Khan University Hospital Nairobi, Kenya. Population: first time parturients in spontaneous labour at term. Methods: women were randomised to receive 40mg of hyoscine-N-butylbromide or sterile water for injection intravenously once they were confirmed to be in active labour. The dose could be repeated once after four hours. Outcome measures: the main outcome measure was the duration of labour from diagnosis of active stage to delivery. Secondary outcome measures were rate of cervical dilatation and postpartum satisfaction score. Safety aspects such as drug adverse effects, APGAR scores and postpartum hemorrhage were explored. Results: a total of 85 were randomised and 79 yielded data for analysis. Of these 37 received hyoscine-N
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Refai on buscopan interactions: Scopolamine butylbromide (buscopan) is an antispasmodic agent used to treat irritable bowel and/or menstrual cramps etc...This med is also available as a combo with paracetamol =buscopan plus, thus has been shown as safe. So if you have buscopan, adding paracetamol in recommended dosage should be ok. Consult doc if you encounter problem. Good luck.
Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.
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Question - Stomach pain, relief on urinating, passing faeces. Prescribed movivol, buscopan. History of adrenal and autoimmune disorders, IBS. Treatment?. Ask a Doctor about uses, dosages and side-effects of Lansoprazole, Ask a Gastroenterologist
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Buscopan official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
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Indikasjoner:Spasmer og motilitetsforstyrrelser i mage-tarmkanalen. Spasmer og dyskinesier i galleveiene. Spasmer i urinveiene. Krampetilstander i de
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Sreelatha S, Vedavathy Nayak*, Gayathri C , Renuka Ramaiah. ABSTRACT. Objective: The purpose of this study was to assess whether hyoscine butyl bromide is effective in improving cervical effacement and dilatation, thus reducing the duration of first stage of labour without causing any maternal and neonatal complications. Materials and Methods: It was a prospective, comparative, observational study. 80 women with term pregnancies in active labour were recruited for the study. They were allocated into 2 groups, study and control group each with 40 patients. The duration of active labour was taken from 3 cm dilatation to full dilatation of the cervix. The study group received 40 mg HBB as slow I V injection (over 1 - 2 min) given at hourly intervals up to a maximum of 3 doses starting at 3 cm dilatation. Results: The mean duration of active phase of labour was 109.28 ± 58. 42 minutes in the study group and 317.48 ± 108.9 in the control group. The difference between the 2 groups was statistically ...
Manufacturer of Active Pharmaceutical Ingredients By Alphabet H - Haloperidol, Hydrochlorothiazide, Hydrocortisone and Hyoscine Butyl Bromide offered by KPS Chemicals & Pharmaceuticals, Surat, Gujarat.
My Gastro thinks I may have symptoms of IBS in addition to my diagnosed crohns. Ive been having lots of very bad spasm type pains, lots of bowel movements, of which not all are diahorrea, generally feeling lots of pain in my abdomen high up and low down. My CRP has been relatively ok over the last couple of weeks (15 -30) I know this as I am having weekly blood tests, so it doesnt feel like a flare. The pain has been far worse than anything Ive experienced and quite frightening. Im so confused, my gastro isnt keen on me taking IBS meds like Buscopan as she says it could slow my bowel and cause a blockage. Ive taken some peppermint oil to try and help but its not really worked. I dont know what to do, im not coping very well in general and worrying about going to work crying a lot. I just know I cant continue with this pain. Has anyone any experience with having IBS in addition to IBD, it just feels like a bad joke that we could have both ...
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Wow, the past week has been a difficult journey for me. Ive been to the hospital and back due to abnominal pains. Ill share this with you, hopefully to help those who have the same concern. June 8 - I was brought to the emergency for severe stomach pains. I was given Buscopan through IV.…
It sounds as if your little girl has a post nasal drip problem. It is the mucous running backwards down her throat and then being swallowed and ending up in her stomach that causes her to have this tummy ache.The mucous drip also causes her to cough.Try to keep her nose as clear as possible by using a saline nasal spray twice daily. Chldren quite like the Sterimar sea water nasal spray.She does not need Buscopan or antihistamines such as Allergex or Deselex.. ...
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Overview Last lecture of the first series here. Tomorrow, well begin the next organic section. For now, a 50 minute lecture on E1 reactions to close things out. Details Again, we have tert butyl bromide. It is a tertiary alkyl halide. (CH3)3CBr ( Heat at 55 C in EtOH/solvolysis) = (CH3)3COEt 72%SN1 + 28% CH3CCH3CH2 E1…
Remifentanil (RMFNT) is a very short active opioid, used for analgesia during general anaesthesia and for analgesic and sedative effect in intensive care units (ICU) patients. Registration for anesthesia includes bolus dose and continuous infusion, in ICU only infusion regimen is allowed. Pharmacokinetic/pharmacodynamic parameters of RMFNT results in rapid onset and offset of clinical effect, which makes this drug almost ideal in many situations. Unfortunately, its vagomimetic influence on cardiac activity may result in decrease of heart rate. It may be hypothesized that patients with parasympathetic predominance may be prone to more intense parasympathomimetic effect of this opioid. An optimal method for assessment of autonomic nervous system activity and assessment of influence of RMFNT on that activity is Heart Rate Variability (HRV) analysis. Parasympathetic predominance is expressed as high frequency (HF) power and HF/(LF+HF) (LF-low frequency) ratio in frequency domain and Root Mean Square ...
This study investigated the pattern and determinants of hyoscine (scopolamine) use for death rattle by a retrospective analysis of 100 consecutive deaths in a 22-bed hospice. Patient diagnoses, duration of stay, and doses and route of administration of hyoscine used in the final 48 hr before death were recorded. One-half of the patients received hyoscine in some form during the final 24 hr before death. Patients who were in the hospice for longer than 9 days and those with cerebral malignancy were given the highest doses of hyoscine in the final 24 hr (z = -2.558, P = 0.011, and z = -1.968, P = 0.048, respectively). Response to hyoscine appears to be variable, and a distinction is proposed between death while due to salivary secretions (type 1) and that due to bronchial secretions (type 2) to explain the observed patterns of use. It is likely that hyoscine is more efficacious in treating type 1 death rattle than it is in treating type 2 death rattle.. ...
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Results 2129 colonoscopies were completed during the study period across three endoscopy units. After exclusion of incomplete data, study groups significantly differed by age demographics. By excluding patients older than 74 y, study groups (n = 914 without MEI, n = 359 with MEI) had similar age (p = 0.06) and gender (p = 0.962) characteristics. MEI use did not significantly influence colonoscopy completion (97.2% vs 96.3%, (p = 0.412)) or polyp detection (24.8% vs 29.1%, (p = 0.132)). Colonoscopies completed without MEI were associated with higher doses of midazolam (1.618 mg ± 0.051 vs 1.379 mg ± 0.097, p , 0.001), fentanyl (1.313 μg ± 0.557 vs 0.348 0μg ± 0.493, p = 0.044), pethidine (24.858 mg ± 0.986 vs 23.259 mg ± 1.784, p = 0.104) and buscopan (16.247 mg ± 0.526 vs 13.510 mg ± 1.041, p , 0.001). Comfort scores and patient satisfaction outcomes were sub-analysed in colonoscopies completed without analgesia or sedation (n = 244). MEI use did not significantly affect endoscopist (p ...
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21.8%, respectively). In a study by de Brouwer et al. 41, there was no difference in the PDR, ADR or mean number of polyps detected per patient, in an Italian double-blind, randomized trial comparing hyoscine and placebo 28.. The present study also did not demonstrate any difference in the PDR, ADR, or mean number of detected polyps or adenomas per patient when comparing hyoscine with placebo.. In contrast to the findings of Rondonotti et al. 28, who encountered significantly fewer non-polypoid colorectal lesions in the hyoscine group, we found significantly more non-polypoid colorectal lesions in the hyoscine arm. Our findings refute the hypothesis that spasmolytic agents would hinder the identification of flat lesions by stretching of the colon. However, de Brouwer et al. 41 identified no difference in the morphology of the diagnosed colorectal lesions, when comparing hyoscine and placebo.. We observed a longer withdrawal time in the placebo group, which in our study, was associated with the ...
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After 2 years of almost constant flares, weight loss, nausea, pain, bloating, and depression from Crohns disease my docs finally decided surgery was my best next option. Last week in preparation for my surgery, my surgeon did the scope thing in my ostomy while I was under whats called conscious sedation. Since that day my ostomy has worked perfectly. No pain, no nausea, my appetite has gone through the roof. I cant even make it through a nights sleep now without getting up to eat something. Im gaining weight, strength and endurance and I feel as good as I did before this flaired up 2 years ago. What could have changed since having that scope done? He said all of my disease was located in the first 4 inches past my ostomy and he had to go through a stricture to see past that part, all the rest behind it was healthy. Im very thankful but surprised at the change in my health ...
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Why might you want to add peppermint to your natural medicine chest? Here are 21 valuable uses for this therapeutic plant.2. 1. Irritable Bowel Syndrome (IBS). Peppermint oil capsules have been described as "the drug of first choice" in IBS patients,3 as it safely helps alleviate symptoms and improve quality of life. Research has shown that it is effective in children and adults alike, with one study showing a 50 percent reduction in "total irritable bowel syndrome score" among 75 percent of patients who tried it.4. 2. Colonic Spasm and Gas. Peppermint oil is an effective alternative to drugs like Buscopan for reducing colonic spasms.5 It may also relax the muscles of your intestines, allowing gas to pass and easing abdominal pain. Try peppermint oil or leaves added to tea for gas relief.. 3. Gastric Emptying Disorders. In people with functional gastrointestinal disorders, peppermint may be useful to enhance gastric emptying.6. 4. Functional Dyspepsia (Upset Stomach and ...
Why might you want to add peppermint to your natural medicine chest? Here are 21 valuable uses for this therapeutic plant.2. 1. Irritable Bowel Syndrome (IBS). Peppermint oil capsules have been described as "the drug of first choice" in IBS patients,3 as it safely helps alleviate symptoms and improve quality of life. Research has shown that it is effective in children and adults alike, with one study showing a 50 percent reduction in "total irritable bowel syndrome score" among 75 percent of patients who tried it.4. 2. Colonic Spasm and Gas. Peppermint oil is an effective alternative to drugs like Buscopan for reducing colonic spasms.5 It may also relax the muscles of your intestines, allowing gas to pass and easing abdominal pain. Try peppermint oil or leaves added to tea for gas relief.. 3. Gastric Emptying Disorders. In people with functional gastrointestinal disorders, peppermint may be useful to enhance gastric emptying.6. 4. Functional Dyspepsia (Upset Stomach and ...
Erythromycin and its derivatives are known to induce phase III-like contractions, which are similar to those induced by motilin, in the human gastrointestinal tract during the interdigestive state, but few detailed in vitro studies have been reported. We evaluated EM574, an erythromycin derivative, as a motilin receptor agonist in the human gastric antrum in vitro, using contraction studies of muscle strips and isolated myocytes, receptor binding assay and tissue section autoradiography. EM574 stimulated contractions of muscle strips in a concentration-dependent manner (10(-7)-10(-5) M), and this contractile effect was unaffected by pretreatment with atropine or tetrodotoxin. Isolated myocytes contracted in response to EM574 with a peak shortening at 10(-7) M, which was comparable to the response to motilin. EM574 displaced specifically 125I-motilin bound to smooth muscle homogenates with a Kd value of 7.8 x 10(-9) M, compared with 4.5 x 10(-9) M for motilin. Film autoradiograms showed that ...
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This medicine is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 months of age for selected conditions, precautions do apply.. ...
This medicine is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 months of age for selected conditions, precautions do apply.. ...
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Promethazine is used to treat nausea and other conditions. As this eMedTV page explains, promethazine comes in tablet, syrup, rectal suppository, and injectable form. This article also explains how the drug works and lists possible side effects.
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To dissociate the effects of an elevated blood pressure on the cardiovascular regulatory functions from those of aging in the hypertensive elderly individual, resting hemodynamic measurements and circulatory autonomic functions in 30 elderly (mean age, 66 years) hypertensive (World Health Organization stages I and II) patients were compared with those in 30 healthy elderly (mean age, 65 years) normotensive volunteers. The elderly hypertensive group showed a significantly lower cardiac index and higher total peripheral resistance. beta-Receptor sensitivity, as determined by chronotropic dose of infused isoproterenol, and baroreceptor reflex sensitivity index, derived from phase II, but not phase IV, of Valsalvas maneuver, were only slightly but significantly reduced in the hypertensive group. The variability of heart rate at rest as an index of parasympathetic control of heart was similar between these two groups. Plasma norepinephrine level was significantly inversely related to resting mean ...
We report two patients with increased central skull base and craniocervical junction bone pneumatisation complicated by extra-osseous gas. One patient presented with symptoms of increasing nasal blockage and sinus pressure on a background of extensive nasal polyposis. He was subsequently found to have a history of repeated Valsalvas manoeuvre, the cessation of which resulted in a rapid decrease in the amount of extra-osseous gas on imaging. The second patient presented following a minor head trauma with dysarthria from a hypoglossal nerve palsy and neck pain, with extensive intra- and extra-cranial gas including within the spinal canal (pneumorrhachis ...
Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take this medicine for a long time.. Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.. Do not consume alcoholic beverages, or prescription or non-prescription medications that have alcohol, while on this medicine. Taking this medicine with alcohol can be very ...
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Figure 5. Social novelty may be slightly affected by phase and genotype. A, Time spent in the chamber shows that there was a near significant interaction a phase × genotype × chamber. A post hoc pairwise analysis showed a significant difference between the times spent in the chamber with the familiar mouse in the active phase for control (n=27 active phase) (n=22 inactive phase) and Fmr1 KO (n=33 active phase) (n=21 inactive phase) mice. There was also a near significant preference in the time spent in the chamber with the novel mouse compared with the familiar mouse in the Fmr1 KO mice during the active phase only. B, Both control and Fmr1 KO mice showed a preference for social novelty based on the time spent sniffing the novel mouse compared with the familiar mouse. This did not differ by genotype or phase. ∗ (p,0.05); ∼ (0.05,p,0.10). Each bar represents the mean +/− SEM for the number of mice indicated in parentheses. ...
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... butylscopolammonium bromide MeSH D03.132.889.848.661.550 --- n-methylscopolamine MeSH D03.132.920.256 --- cevanes MeSH D03.132. ... butylscopolammonium bromide MeSH D03.605.869.900.700.550 --- n-methylscopolamine MeSH D03.661.243.320 --- 4- ... pyridostigmine bromide MeSH D03.383.725.762.760 --- pyrithiamine MeSH D03.383.725.762.900 --- trimedoxime MeSH D03.383.725.762. ...
Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in ... Bromide, Butylscopolammonium; Bromide, N-Butylscopolammonium; Hyoscine N Butylbromide; N Butylscopolammonium Bromide; N- ... Butylscopolammonium Bromide (Butylscopolamine). Subscribe to New Research on Butylscopolammonium Bromide Antimuscarinic ... 07/01/2015 - "N-butylscopolammonium bromide (NBB) is an anticholinergic agent used to treat spasmodic colic in horses. ". 11/01 ...
This is equivalent to 30 mg N-butylscopolammonium bromide per 100 kg (220 pounds) body weight or 1.5 mL of Buscopan Injectable ... Generic Name: n-butylscopolammonium bromide injection. Dosage Form: FOR ANIMAL USE ONLY. ... The chemical name for the active constituent of Buscopan Injectable Solution is N-butylscopolammonium bromide. It is a water ... Buscopan Injectable Solution is supplied in 50 mL multi-dose vials containing 20 mg N-butylscopolammonium bromide per mL. ...
Butylscopolammonium Bromide. Antiemetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. ...
Butylscopolammonium Bromide. Methylprednisolone. Prednisolone acetate. Methylprednisolone acetate. Methylprednisolone ...
Butylscopolammonium Bromide. Cholinergic Antagonists. Psychotropic Drugs. Adjuvants, Anesthesia. Mydriatics. Autonomic Agents. ...
Butylscopolammonium Bromide. Narcotic Antagonists. Physiological Effects of Drugs. Sensory System Agents. Peripheral Nervous ... Drug Information available for: Scopolamine Scopolamine hydrobromide Butylscopolamine bromide Naltrexone Naltrexone ...
Butylscopolammonium Bromide. Adjuvants, Anesthesia. Antiemetics. Autonomic Agents. Peripheral Nervous System Agents. ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Each ml of Buscopan Injectable Solution contains 20 mg N-butylscopolammonium bromide. Buscopan Injectable Solution is ...
Two searches: [Biliary colic/ or analgesia for biliary colic mp.] and [buscopan or butylscopolammonium bromide] undertaken. ... In [adults with biliary colic and no evidence of infection] is [buscopan(hyoscine bromide) better than/equal to analgesics] in ...
N-butylscopolammonium bromide is not approved by the FDA, and the use of dipyrone in food animals in the USA is prohibited. ... N-butylscopolammonium bromide (nonlactating adult cattle: 0.2 mg/kg, IM or IV; calves: 0.4 mg/kg, IM or IV) is a ... Administration of N-butylscopolammonium bromide (80 mg/cow) in combination with dipyrone has been proposed as a conservative ...
... "butylscopolammonium bromide" (both as medical subject headings and free text terms), and the following free text terms: " ... ", "pinaverium bromide", "otilonium bromide", "cimetropium bromide", "hyoscine butyl bromide", "butylscopolamine", "peppermint ...
... butropium bromide, n-butylscopolammonium bromide, caroverine, cimetropium bromide, cinnamedrine, clebopride, coniine ... emepronium bromide, ethaverine, feclemine, fenalamide, fenoverine, fenpiprane, fenpiverinium bromide, fentonium bromide, ... pinaverium bromide, piperilate, pipoxolan hydrochloride, pramiverin, prifinium bromide, properidine, propivane, propyromazine, ... codeine methyl bromide, codeine phosphate, codeine sulfate, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine ...
... butylscopolammonium bromide MeSH D03.132.889.848.661.550 --- n-methylscopolamine MeSH D03.132.920.256 --- cevanes MeSH D03.132. ... butylscopolammonium bromide MeSH D03.605.869.900.700.550 --- n-methylscopolamine MeSH D03.661.243.320 --- 4- ... pyridostigmine bromide MeSH D03.383.725.762.760 --- pyrithiamine MeSH D03.383.725.762.900 --- trimedoxime MeSH D03.383.725.762. ...
Sanchez LC, Elfenbein JR, Robertson SA: Effect of acepromazine, butorphanol, or N-butylscopolammonium bromide on visceral and ...
Butylscopolammonium Bromide. Interventional clinical trials:. (show all 32) #. Name. Status. NCT ID. Phase. Drugs. ...
... butropium bromide, n-butylscopolammonium bromide, caroverine, cimetropium bromide, cinnamedrine, clebopride, coniine ... emepronium bromide, ethaverine, feclemine, fenalamide, fenoverine, fenpiprane, fenpiverinium bromide, fentonium bromide, ... pinaverium bromide, piperilate, pipoxolan hydrochloride, pramiverin, prifinium bromide, properidine, propivane, propyromazine, ... codeine methyl bromide, codeine phosphate, codeine sulfate, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine ...
... butropium bromide, n-butylscopolammonium bromide, caroverine, cimetropium bromide, cinnamedrine, clebopride, coniine ... emepronium bromide, ethaverine, feclemine, fenalamide, fenoverine, fenpiprane, fenpiverinium bromide, fentonium bromide, ... pinaverium bromide, piperilate, pipoxolan hydrochloride, pramiverin, prifinium bromide, properidine, propivane, propyromazine, ... codeine methyl bromide, codeine phosphate, codeine sulfate, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine ...
N-butylscopolammonium bromide, scopolan bromide, butylscopolammonium bromide, N-butylscopolammonium chloride, hyoscine N- ... propantheline bromide, imipramine, mepenzolate bromide, isopropamide iodide, clidinium bromide, including salts and derivatives ... methantheline bromide, emepronium bromide, clindinium, clidinium bromide, hyoscine, hyoscine butylbromide, hyoscine ... quinuclidinium bromide, N-methyl-3-quinuclidinyl benzilat bromide, alpha-methyl-alpha-phenylbenzene-acetic acid quinuclidin-3- ...
... butropium bromide, n-butylscopolammonium bromide, caroverine, cimetropium bromide, cinnamedrine, clebopride, coniine ... emepronium bromide, ethaverine, feclemine, fenalamide, fenoverine, fenpiprane, fenpiverinium bromide, fentonium bromide, ... pinaverium bromide, piperilate, pipoxolan hydrochloride, pramiverin, prifinium bromide, properidine, propivane, propyromazine, ... codeine methyl bromide, codeine phosphate, codeine sulfate, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine ...
Butylscopolammonium Bromide/analysis , Butylscopolammonium Bromide/chemistry , Chemistry, Pharmaceutical/methods , ... Aims: A simple RP-TLC Spectrodensitometric method was developed for determination of Hyoscine N-Butyl Bromide (HBB) and ... Simultaneous Determination of Hyoscine N- Butyl Bromide and Paracetamol by RP-TLC Spectrodensitometric Method. ...
  • Antispasmodic activity of propinox, (-) scopolamine-n-butyl bromide, atropine and verapamil was determined in human gallbladders to reduce the risk of interspecies variability. (bvsalud.org)
  • scopolamine-n-butyl1 bromide 5.4x10(-5) M. pD'2 for propinox was 6.94, indicating non competitive inhibition of carbachol action. (bvsalud.org)
  • For the benzothiacepine binding sites, Ki for propinox was 5.2x10(-6)M. The following may be concluded: 1- The antispasmodic activity of propinox in isolated human galbladder was was comparatively less potent than of atropine and more potent than those verapamil and (-) scopolamine-n-butyl bromide. (bvsalud.org)
  • Antimicrobial activity against bacteria and fungi was evaluated by the modified agar well method, cytotoxicity to BHK-21 cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, and toxicity against Artemia salina. (bvsalud.org)