AnatomyOrganismsDiseasesChemicals and DrugsPhenomena and Processes
Buthionine SulfoximineMethionine SulfoximineGlutathioneGlutamate-Cysteine LigaseMaleatesAntimetabolitesAcetylcysteineGlutathione SynthaseGlutathione DisulfideCystineOxidative StressPyrrolidonecarboxylic AcidGlutathione ReductaseCell SurvivalOxidation-ReductionDrug ResistanceDiamideMelphalanSulfhydryl CompoundsAntioxidantsReactive Oxygen Speciesgamma-GlutamyltransferaseHydrogen PeroxideGlutathione PeroxidaseDrug SynergismOxidantsEnzyme InhibitorsArsenicalsGlutathione TransferaseGlutamate-Ammonia LigaseAntimetabolites, AntineoplasticTumor Cells, CulturedCysteineCatalaseDose-Response Relationship, DrugCells, CulturedLiverApoptosisLeydig CellsRats, Inbred BNTestosteroneSteroidsLeydig Cell Tumor
Buthionine Sulfoximine
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Methionine Sulfoximine
Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Glutamate-Cysteine Ligase
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Maleates
Antimetabolites
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
Acetylcysteine
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
Glutathione Synthase
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of glutathione from gamma-glutamylcysteine and glycine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.3.
Glutathione Disulfide
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
Cystine
A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Pyrrolidonecarboxylic Acid
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
Glutathione Reductase
Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
Cell Survival
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Diamide
A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.
Melphalan
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Sulfhydryl Compounds
Compounds containing the -SH radical.
Antioxidants
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
gamma-Glutamyltransferase
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Hydrogen Peroxide
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Glutathione Peroxidase
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
Drug Synergism
The action of a drug in promoting or enhancing the effectiveness of another drug.
Oxidants
Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION).
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Arsenicals
Inorganic or organic compounds that contain arsenic.
Glutathione Transferase
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Glutamate-Ammonia Ligase
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
Antimetabolites, Antineoplastic
Antimetabolites that are useful in cancer chemotherapy.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Cysteine
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Catalase
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Leydig Cells
Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
Rats, Inbred BN
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Leydig Cell Tumor
Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.

Influence of glutathione levels and heat-shock on the steady-state levels of oxidative DNA base modifications in mammalian cells. (1/573)

The effects of thiols, ascorbic acid and thermal stress on the basal (steady-state) levels of oxidative DNA base modifications were studied. In various types of untreated cultured mammalian cells, the levels of total glutathione were found to be inversely correlated with the levels of DNA base modifications sensitive to the repair endonuclease Fpg protein, which include 8-hydroxyguanine (8-oxoG). A depletion of glutathione by treatment with buthionine sulphoximine increased the steady-state level in AS52 Chinese hamster cells by approximately 50%. However, additional thiols in the culture medium did not reduce the level of Fpg-sensitive base modifications: 0-10 mM N-acetylcysteine had no effect, whereas cysteine ethylester even increased the oxidative DNA damage at concentrations >0.1 mM. Similarly, ascorbic acid (0-20 mM) failed to reduce the steady-state levels. When AS52 cells were grown at elevated temperature (41 degrees C), the steady-state level of the oxidative DNA modifications increased by 40%, in spite of a concomitant 1.6-fold increase of the cellular level of total glutathione. Depletion of glutathione at 41 degrees C nearly doubled the already elevated level of oxidative damage. A constitutive expression of the heat-shock protein Hsp27 in L929 mouse fibrosarcoma cells at 37 degrees C increased the glutathione level by 60%, but had little effect on the level of oxidative DNA damage.  (+info)

Role of antioxidant defenses against ethanol-induced damage in cultured rat gastric epithelial cells. (2/573)

Reactive oxygen species appears to be involved in the pathogenesis of ethanol-induced gastric mucosal injury in vivo. Because ingested ethanol diffuses into the gastric mucosa, targeting both epithelium and endothelium, in the present study we examined the possible protective effect of antioxidants on ethanol damage in gastric epithelial cells and endothelial cells in vitro. Cytotoxicity by ethanol was quantified by measuring 51Cr release. The effects of impairment of the glutathione redox cycle and of inhibition of cellular catalase were examined. The generation of superoxide was assessed by the reduction in cytochrome c. Ethanol caused a time- and dose-dependent increase in 51Cr release from epithelial cells. Incubation of cells with DL-buthionine-(S,R)-sulfoximine, while reducing glutathione production, dose dependently enhanced ethanol-induced injury. 1,3-Bis(chloroethyl)-nitrosourea, while inhibiting glutathione reductase activity, also sensitized cells to ethanol. In contrast, the inhibition of catalase with 3-amino-1,2, 4-triazole did not alter the susceptibility of epithelial cells to ethanol. Ethanol induced damage to endothelial cells in a similar fashion. In endothelial cells, however, neither impairment of the glutathione cycle nor inhibition of catalase influenced ethanol-induced damage. Epithelial cells, when exposed to ethanol, increased superoxide production as a function of ethanol concentration, whereas endothelial cells did not. The glutathione redox cycle, but not cellular catalase, plays a critical role in protecting epithelial cells against ethanol damage, whereas neither antioxidant seems to play a role in protection of endothelial cells. The distinct difference in antioxidant protection against ethanol appears to depend on the capability of each cell to produce cytotoxic oxygen species in response to ethanol exposure.  (+info)

Involvement of N-acetylcysteine-sensitive pathways in ricin-induced apoptotic cell death in U937 cells. (3/573)

We have found that the antioxidant N-acetylcysteine (NAC) strongly inhibited ricin-induced apoptotic cell death in U937 cells (human myeloid leukemia), as judged by cytotoxicity, nuclear morphological change, and DNA fragmentation. Consistent with these observations, a significant depletion of cellular glutathione was observed in ricin-treated cells, and NAC prevented the decrease in cellular glutathione. On the other hand, among the caspase inhibitors tested, Z-Asp-CH2-DCB, which inhibited ricin cytotoxicity, also suppressed ricin-mediated glutathione depletion, while NAC did not affect the generation of caspase-3 like activity in ricin-treated cells. These results suggest that glutathione loss takes place downstream from caspase activation during the ricin-induced apoptotic process. Treatment with a specific inhibitor of glutathione biosynthesis, buthionine sulfoximine (BSO) failed to induce apoptosis, and had no effect on the overall extent of ricin-induced apoptosis, even though the glutathione level was decreased to less than 5% of the control level. However, NAC still protected against ricin-induced apoptosis in the BSO-treated cells. We conclude that glutathione loss is one of several apoptotic changes caused by ricin, but is not a sufficient factor for the progress of apoptosis. NAC may prevent ricin-induced apoptosis through maintaining an intracellular reducing condition by acting as a thiol supplier.  (+info)

Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione. (4/573)

The mechanism of cell death caused by cytokine deprivation remains largely unknown. FL5.12 cells (a murine prolymphocytic cell line), following interleukin-3 (IL-3) withdrawal, undergo a decrease in intracellular glutathione (GSH) that precedes the onset of apoptosis. In the present study, the induction of apoptosis following IL-3 withdrawal or GSH depletion with DL-buthionine-[S,R,]-sulfoximine (BSO) was examined. Both conditions caused time-dependent increases in phosphatidylserine externalization, acridine orange and ethidium bromide staining, decreases in mitochondrial membrane potential, processing and activation of caspase-3 and proteolysis of the endogenous caspase substrate poly(adenosine diphosphate ribose)polymerase (PARP). Apoptosis induced by IL-3 deprivation but not BSO also caused lamin B1 cleavage, suggesting activation of caspase-6. Despite a more profound depletion of GSH after BSO than withdrawal of IL-3, the extent of apoptosis was somewhat lower. Benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone (z-VAD.fmk) blocked this caspase activity and prevented cell death after BSO exposure but not after IL-3 deprivation. Following IL-3 withdrawal, the caspase inhibitors z-VAD.fmk and boc-asp(OMe)fluoromethylketone (boc-asp.fmk) prevented the cleavage and activation of caspase-3, the breakdown of lamin B1 and partially mitigated PARP degradation. However, the externalization of phosphatidylserine, the fall in mitochondrial membrane potential and subsequent apoptotic cell death still occurred. These results suggest that IL-3 withdrawal may mediate cell death by a mechanism independent of both caspase activation and the accompanying loss of GSH.  (+info)

ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. (5/573)

Non-P-glycoprotein-mediated multidrug-resistant C-A120 cells that overexpressed multidrug resistance protein (MRP) were 10.8- and 29. 6-fold more resistant to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) and SN-38, respectively, than parental KB-3-1 cells. To see whether MRP is involved in CPT-11 and SN-38 resistance, MRP cDNA was transfected into KB-3-1 cells. The transfectant, KB/MRP, which overexpressed MRP, was resistant to both CPT-11 and SN-38. 2-[4-Diphenylmethyl)-1-piperazinyl]ethyl-5-(trans-4,6-dimethyl-1,3 , 2-dioxaphosphorinan-2-yl)-2, 6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide (PAK-104P) and MK571, which reversed drug resistance in MRP overexpressing multidrug-resistant cells, significantly increased the sensitivity of C-A120 and KB/MRP cells, but not of KB-3-1 cells, to CPT-11 and SN-38. The accumulation of both CPT-11 and SN-38 in C-A120 and KB/MRP cells was lower than that in KB-3-1 cells. The treatment with 10 microM PAK-104P increased the accumulation of CPT-11 and SN-38 in C-A120 and KB/MRP cells to a level similar to that found in KB-3-1 cells. The ATP-dependent efflux of CPT-11 and SN-38 from C-A120 and KB/MRP cells was inhibited by PAK-104P. DNA topoisomerase I expression, activity, and sensitivity to SN-38 were similar in the three cell lines. Furthermore, the conversion of CPT-11 to SN-38 in KB-3-1 and C-A120 cell lines was similar. These findings suggest that MRP transports CPT-11 and SN-38 and is involved in resistance to CPT-11 and SN-38 and that PAK-104P reverses the resistance to CPT-11 and SN-38 in tumors that overexpress MRP.  (+info)

Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione. (6/573)

The oncoprotein Bcl-2 protects cells against apoptosis, but the exact molecular mechanism that underlies this function has not yet been identified. Studying H2O2-induced cell injury in Rat-1 fibroblast cells, we observed that Bcl-2 had a protective effect against the increase in cytosolic calcium concentration and subsequent cell death. Furthermore, overexpression of Bcl-2 resulted in an alteration of cellular glutathione status: the total amount of cellular glutathione was increased by about 60% and the redox potential of the cellular glutathione pool was maintained in a more reduced state during H2O2 exposure compared with non-Bcl-2-expressing controls. In our cytotoxicity model, disruption of cellular glutathione homoeostasis closely correlated with the pathological elevation of cytosolic calcium concentration. Stabilization of the glutathione pool by Bcl-2, N-acetylcysteine or glucose delayed the cytosolic calcium increase and subsequent cell death, whereas depletion of glutathione by dl-buthionine-(S, R)-sulphoximine, sensitized Bcl-2-transfected cells towards cytosolic calcium increase and cell death. We therefore suggest that the protection exerted by Bcl-2 against H2O2-induced cytosolic calcium elevation and subsequent cell death is secondary to its effect on the cellular glutathione metabolism.  (+info)

Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations. (7/573)

Hyperglycemia-induced embryonic malformations may be due to an increase in radical formation and depletion of intracellular glutathione (GSH) in embryonic tissues. In the past, we have investigated the role of the glutathione-dependent antioxidant system and GSH on diabetes-related embryonic malformations. Embryos from streptozotocin-induced diabetic rats on gestational day 11 showed a significantly higher frequency of embryonic malformations (neural lesions 21.5 vs. 2.8%, P<0.001; nonneural lesions 47.4 vs. 6.4%, P<0.001) and growth retardation than those of normal mothers. The formation of intracellular reactive oxygen species (ROS), estimated by flow cytometry, was increased in isolated embryonic cells of diabetic rats on gestational day 11. The concentration of intracellular GSH in embryonic tissues of diabetic pregnant rats on day 11 was significantly lower than that of normal rats. The activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting GSH synthesizing enzyme, in embryos of diabetic rats was significantly low, associated with reduced expression of gamma-GCS mRNA. Administration of buthionine sulfoxamine (BSO), a specific inhibitor of gamma-GCS, to diabetic rats during the period of maximal teratogenic susceptibility (days 6-11 of gestation) reduced GSH by 46.7% and increased the frequency of neural lesions (62.1 vs. 21.5%, P<0.01) and nonneural lesions (79.3 vs. 47.4%, P<0.01). Administration of GSH ester to diabetic rats restored GSH concentration in the embryos and reduced the formation of ROS, leading to normalization of neural lesions (1.9 vs. 21.5%) and improvement in nonneural lesions (26.7 vs. 47.4%) and growth retardation. Administration of insulin in another group of pregnant rats during the same period resulted in complete normalization of neural lesions (4.3 vs. 21.5%), nonneural lesions (4.3 vs. 47.4%), and growth retardation with the restoration of GSH contents. Our results indicate that GSH depletion and impaired responsiveness of GSH-synthesizing enzyme to oxidative stress during organogenesis may have important roles in the development of embryonic malformations in diabetes.  (+info)

Molecular basis for hepatic detoxifying enzyme induction by 2-(allylthio)pyrazine in rats in comparison with oltipraz: effects on prooxidant production and DNA degradation. (8/573)

The expression of hepatic microsomal epoxide hydrolase (mEH) and glutathione S-transferases (GSTs) by 2-(allylthio)pyrazine (2-AP), an experimental chemopreventive agent, was investigated in rats. Northern blot analysis revealed that 2-AP caused increases in mEH, rGSTA2/3/5, and rGSTM1/2 mRNA levels. mEH and rGSTA2 proteins were also induced. Molecular basis of the enzyme induction by 2-AP was studied in comparison with oltipraz (Olt). Rats exposed to buthionine sulfoximine, a GSH-depleting agent, before treatment with either 2-AP or Olt exhibited greater increases in the mRNA levels than the individual treatment. Conversely, increases of the mRNAs were prevented by cysteine treatment, indicating that metabolic intermediates or reactive oxygens produced from the agents could be reduced by cysteine. Gel shift analysis revealed that nuclear factor-kappaB, which is associated with the altered cellular redox state, was not activated by the agents. Effects of these agents on the breakage of phix-174 DNA were compared in vitro. 2-AP effectively reduced the conversion of supercoiled DNA to the open circular form induced by benzenetriol and prevented benzenetriol- and iron-catalyzed degradation of DNA, whereas Olt failed to prevent strand breakage of DNA. These results provided evidence that: 1) 2-AP was effective in elevating the hepatic mEH and GST gene expression in rats, which might be mediated with the production of reactive oxygen species; 2) nuclear factor-kappaB activation was not involved in the induction of the detoxifying enzymes by either 2-AP or Olt in spite of their production of reactive oxygens in vivo; and 3) the antioxidant effect of 2-AP in vitro differed from that of Olt.  (+info)

Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock...Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock...
TY - JOUR. T1 - Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure. AU - Cuzzocrea, Salvatore. AU - Zingarelli, Basilia. AU - OConnor, Michael. AU - Salzman, Andrew L.. AU - Szabo, Csaba. PY - 1998. Y1 - 1998. N2 - 1. Peroxynitrite, a cytotoxic oxidant formed from the reaction of nitric oxide (NO) and superoxide is a mediator of cellular injury in ischaemia/reperfusion injury, shock and inflammation. Here we investigated whether L-buthionine-(S,R)-sulphoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase, alters endothelial and vascular smooth muscle injury in response to peroxynitrite in vitro and during endotoxic shock in vivo. 2. In human umbilical vein endothelial cells and in rat aortic smooth muscle cells, BSO (1 mM, for 24 h) enhanced, whereas glutathione (3 mM) or glutathione ethyl ester (3mM) attenuated the peroxynitrite (100-1000 μM)-induced suppression of mitochondrial ...
https://researchexperts.utmb.edu/en/publications/effect-of-l-buthionine-sr-sulphoximine-an-inhibitor-of-%CE%B3-glutamyl
Dual role of glutathione in modulating camptothecin activity: Depletion potentiates activity, but conjugation enhances the...Dual role of glutathione in modulating camptothecin activity: Depletion potentiates activity, but conjugation enhances the...
Depletion of glutathione (GSH) in MCF-7 and MDA-MB-231 cell lines by pretreatment with the GSH synthesis inhibitor buthionine sulfoximine potentiated the activity of 10,11-methylenedioxy-20(S)-camptothecin, SN-38 [7-ethyl-10-hydroxy-20(S)-camptothecin], topotecan, and 7-chloromethyl-10,11-methylenedioxy-20(S)camptothecin (CMMDC). The greatest potentiation was observed with the alkylating camptothecin CMMDC. Buthionine sulfoximine pretreatment also increased the number of camptothecin-induced DNA-protein crosslinks, indicating that GSH affects the mechanism of action of camptothecin.
https://www.rti.org/publication/dual-role-glutathione-modulating-camptothecin-activity-depletion-potentiates-activity
Loss of Biphasic Effect on Na/K-ATPase Activity by Angiotensin II Involves Defective Angiotensin Type 1 Receptor-Nitric Oxide...Loss of Biphasic Effect on Na/K-ATPase Activity by Angiotensin II Involves Defective Angiotensin Type 1 Receptor-Nitric Oxide...
The results of this study show that, in Sprague-Dawley rats, oxidative stress increased BP, which was associated with renal AT1R upregulation and exaggerated signaling. In BSO-treated rats, Ang II caused significantly higher NKA stimulation and failed to cause inhibition of NKA activity, as seen in control rats. Our data shows that AT1R-mediated NKA stimulation by low Ang II concentration involves MAP kinase, whereas the inhibition at high Ang II concentration involves NO-cGMP signaling. Interestingly, whereas picomolar concentration of Ang II showed robust stimulation of MAP kinase in BSO-treated rats, it failed to activate NO-cGMP signaling and inhibit NKA activity at micromolar concentrations. In control rats, Ang II stimulated NADPH oxidase, but the activation of this enzyme was much higher in BSO-treated rats. In addition, Ang II-mediated, AT1R-dependent O2•− production was also contributed by NOS in BSO-treated rats. Furthermore, Ang II-mediated Pyk2 stimulation was also higher in ...
http://hyper.ahajournals.org/content/52/6/1099
The gastrointestinal tract is exposed to pro-oxidants from food, host immune factors, and microbial pathogens, which may induce...The gastrointestinal tract is exposed to pro-oxidants from food, host immune factors, and microbial pathogens, which may induce...
The gastrointestinal tract is exposed to pro-oxidants from food, host immune factors, and microbial pathogens, which may induce oxidative damage. quercetin protection was explored in Caco2. Reversed H2O2-induced cell damage and decreased reactive oxygen species and apoptosis ratio were observed in quercetin-treated cells. Also, quercetin increased expression of the glutamate-cysteine Rocilinostat inhibitor database ligase catalytic subunit (GCLC), the first rate-limiting enzyme of glutathione synthesis, and increased intracellular GSH concentration under H2O2 treatment. This effect was abolished by the GCLC inhibitor buthionine sulfoximine. These results indicated that quercetin can improve cell proliferation and increase intracellular GSH concentrations by upregulating transcription of GCLC to get rid of excessive reactive air species (ROS). Elevated extracellular H2O2 focus induced by quercetin under oxidative tension was linked to the inhibition of AQP3 and upregulation of NOX1/2, which might ...
http://lefiestus16.com/%EF%BB%BFthe-gastrointestinal-tract-is-exposed-to-pro-oxidants-from-food-host-immune-factors-and-microbial-pathogens-which-may-induce-oxidative-damage/
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Cancer stem cells (CSCs) exhibit lower intracellular reactive oxygen species (ROS) levels than non-CSCs, which may be due to the increased expression of free radical scavenging systems. Exogenous agents may be useful to increase ROS and selectively kill CSCs by oxidative stress. Here we tested a combination approach to increase ROS as an effective strategy to eradicate breast CSCs and metastases. Buthionine sulfoximine (BSO) and auranofin (AU) were used to deplete glutathione (GSH) and inhibit thioredoxin reductase (TR), respectively, while mitochondrial-targeted decyltriphenylphosphonium (dTPP) was used to elevate ROS levels. In vitro clonogenicity assays using SUM159 cells showed that treatment with dTPP alone resulted in ,30% survival, while AU+BSO, BSO+dTPP and AU+BSO+dTPP all resulted in ,1% survival. These effects were reversible with N-acetylcysteine pre-treatment. The Aldefluor+ (CSC) population was also measured following drug treatment in vitro. dTPP or AU treatment alone resulted in ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/3729
Cyclic sulfoximine mimics of ribosides and 2-deoxyribosides as enzyme inhibitors - the University of Baths research portal
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
https://researchportal.bath.ac.uk/en/studentTheses/cyclic-sulfoximine-mimics-of-ribosides-and-2-deoxyribosides-as-en
Holidays at KinderRijk - KinderRijkHolidays at KinderRijk - KinderRijk
In de vakantie hebben kinderen van de BSO de mogelijkheid tot vakantieopvang. Meer informatie over de vakantieopvang lees je op kinderrijk.nl.
https://www.kinderrijk.nl/en/childcare/after-school-care-for-ages-4-to-12/holidays-at-kinderrijk/
L-BUTHIONINE (CAS 13073-21-7) Market Research Report 2018L-BUTHIONINE (CAS 13073-21-7) Market Research Report 2018
L-BUTHIONINE (CAS 13073-21-7) Market Research Report 2018 aims at providing comprehensive data on l-buthionine market globally and regionally (Europe,
https://marketpublishers.com/report/industry/chemicals_petrochemicals/l-buthionine_13073-21-7_market_research_report.html
Effects of hypoxia and glutathione depletion on hemoglobin- and myoglobin-mediated oxidative stress toward endothelium. |...Effects of hypoxia and glutathione depletion on hemoglobin- and myoglobin-mediated oxidative stress toward endothelium. |...
We investigated the toxicity of hemoglobin/myoglobin on endothelial cells under oxidative stress conditions that include cellular hypoxia and reduced antioxidant capacity. Bovine aorta endothelial cells (BAECs), grown on microcarrier beads, were subjected to cycles of hypoxia and reoxygenation in a small volume of medium, and endothelial cell monolayers were depleted of their intracellular glutathione (GSH) by treatment with buthionine sulfoximine. Incubation of diaspirin cross-linked hemoglobin (DBBF-Hb) or horse skeletal myoglobin (Mb) with BAECs subjected to 3 h of hypoxia caused transient oxidation of the hemoproteins to the ferryl form (Fe(4+)). Formation of the ferryl intermediate was decreased in a concentration-dependent manner by the addition of L-arginine, a substrate of NO synthase, after 3 h of hypoxia. Optimal inhibition of ferryl formation, possibly due to the antioxidant action of NO, was achieved with 900 microM L-arginine. Addition of hydrogen peroxide to GSH-depleted cells in the
https://www.semanticscholar.org/paper/Effects-of-hypoxia-and-glutathione-depletion-on-and-D%27agnillo-Wood/098de3fa69e3f7d5b4bfecabdf617a20cc79a4bb
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A chlorambucil (CLB)-resistant cell line, N50-4, was developed from the established mouse fibroblast cell line NIH 3T3, by multistep drug selection. The mutant cells exhibited greater than 10-fold resistance to CLB. Alterations in GSH and glutathione S-transferase (GST) were found in CLB-resistant variants. A 7-10-fold increase in cellular GSH content and a 3-fold increase in GST activity were detected in N50-4 cells, compared with parental cells, as determined by enzymatic assays. An increase in steady state levels of the GST-alpha isozyme mRNA was found in the CLB-resistant cells, as analyzed by Northern blotting. No GST gene amplification or rearrangement was shown by Southern blot analysis. To test the relative roles of GSH and GST in CLB resistance, a number of GSH- and GST-blocking agents were used. The CLB toxicity was significantly enhanced in N50-4 cells by administration of either the GSH-depleting agent buthionine sulfoximine or the GST inhibitors ethacrynic acid or indomethacin. The ...
http://molpharm.aspetjournals.org/content/41/4/625
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Stress and starvation increased liver metallothionein (MT) and decreased liver glutathione (GSH) levels. Serum cysteine plus cystine levels were increased by stress. The exogenous administration of GSH, while not modifying hepatic GSH content, increased liver MT levels in basal and starved rats but not in stressed rats. Liver and serum cysteine levels were increased by GSH administration, a process partially reverted by the irreversible inhibitor of gamma-glutamyl transpeptidase, alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid. Mouse and rat liver MT levels were also increased by buthionine sulfoximine, an inhibitor of GSH synthesis, indicating that GSH is not a necessary precursor of MT. In addition, the hepatic MT content was increased by the administration of cysteine in a dose-response manner. These results suggest that hepatic MT synthesis is elevated by increased cysteine pools, and that MT, GSH and cysteine levels are somehow inter-related. MT, besides GSH, may be contemplated as ...
https://jpet.aspetjournals.org/content/255/2/554
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Administration of cyclophosphamide at a dose which is lethal to 10% of control athymic nude mice resulted in sudden death within 3 h in all mice that had been pretreated with the glutathione synthesis inhibitor l-buthionine-SR-sulfoximine. In Fischer 344 rats pretreated with l-buthionine-SR-sulfoximine, the cyclophosphamide dose producing 100% acute toxicity was lowered from 500-150 mg/kg; cardiac monitoring revealed ventricular fibrillation to be the cause of death. These and additional studies reported demonstrate that cytoplasmic glutathione is an important protectant against the cardiac and skeletal muscle toxicity of cyclophosphamide and indicate that such toxicity may be substantially increased by glutathione depletion. Since diet and many drugs (including cyclophosphamide itself) are known to affect glutathione levels, the present studies suggest that cardiac and skeletal muscle glutathione content is likely to be a clinically significant determinant of the frequency and severity of the ...
http://cancerres.aacrjournals.org/content/50/8/2455
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Purpose:Cancer cells (relative to normal cells) demonstrate increased steady-state levels of hydroperoxides that are compensated for by increased glucose and hydroperoxide metabolism. The current study determined if inhibitors of glucose and hydroperoxide metabolism could induce chemo-radio-sensitization by enhancing oxidative stress in lung cancer cells. Experimental Design:A549 and NCI-H292 human lung carcinoma cells were treated with 2-Deoxy-D-glucose (2DG) combined with carboplatin (carbo) + ionizing radiation (IR). Lung cancer cells were further sensitized with inhibitors of glutathione- and thioredoxin-dependent metabolism [buthionine sulfoximine (BSO) and auranofin (Au), respectively] in vitro and in vivo. Results:When 2DG was combined with carbo+IR, clonogenic cell killing was enhanced in A549 and NCI-H292 cells and this combination was more effective than paclitaxel+carbo+IR. The thiol antioxidant (N-acetylcysteine, NAC) was capable of protecting cancer cells from 2DG+carbo-induced cell ...
http://clincancerres.aacrjournals.org/content/early/2011/08/12/1078-0432.CCR-11-0736
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ROS-inducing anticancer drugs such as buthionine sulphoximine, β-lapachone, imexon, and methoxyestradiol that directly target antioxidant pathways have been developed for clinical applications (94). Moreover, many clinically used drugs such as arsenic trioxide, taxol, paclitaxel, doxorubicin, and platinum-derived drugs also induce ROS and this contributes to their overall anticancer activity (rev. in ref. 94). Although ROS-inducing anticancer agents induce DNA damage and both oxidative and ER stress through initial mitochondrial damage, there are also reports that these compounds induce many of the same responses and genes observed after Sp knockdown (Fig. 1). Moreover, initial studies showed that pro-oxidants such as hydrogen peroxide, t-butyl hydroperoxide, pharmacologic doses of ascorbate (generates hydrogen peroxide), and arsenic trioxide downregulated Sp1, Sp3, Sp3, and Sp-regulated genes (71-73). Similar ROS inducers such as curcumin, BITC, HDAC inhibitors, celastrol, CDDO-Me, GT-094, ...
https://cancerpreventionresearch.aacrjournals.org/content/11/7/371
antiagingantiaging
Have you ever heard of glutathione (pronounced; gloota-thigh-own)? Neither has almost anyone else. Many researchers say its probably the most important substance we require to stay healthy. Many go as far to say its the secret to prevent aging. So wheres Oprah, and the rest of the media? A quick search of the term glutathione on PubMed.gov reveals 94,117 scholarly articles, reviews and abstracts. Present in every cell of our body, glutathione levels just might be one of the best biochemical markers there is; the higher your glutathione levels are the healthier you will be. Glutathione deficiency is found in almost all patients with extreme illnesses, e.g., cancer, heart disease, Parkinsons disease, Alzheimers, arthritis, liver disease, diabetes and more. In fact, researchers are concluding glutathione deficiency may play a role in patients with schizophrenia. In cerebrospinal fluid of drug-free schizophrenic patients, a significant decrease in the level of total glutathione was observed ...
http://www.bottomlinefitness.com/tag/antiaging/
Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell...Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell...
Routine cell line maintenance involves removal of waste products and replenishment of nutrients via replacement of cell culture media. Here, we report that routine maintenance of three discrete cell lines (HSB-CCRF-2 and Jurkat T cells, and phaeo-chromocytoma PC12 cells) decreases the principal cellular antioxidant, glutathione, by up to 42% in HSB-CCRF-2 cells between 60 and 120min after media replenishment. However, cellular glutathione levels returned to baseline within 5h after passage. The decrease in glutathione was associated with modulation of the response of Jurkat T cells to apoptotic and mitogenic signals. Methotrexate-induced apoptosis over 16h, measured as accumulation of apoptotic nucleoids, was decreased from 22 to 17% if cells were exposed to cytotoxic agent 30min after passage compared with cells exposed to MTX in the absence of passage. In contrast, interleukin-2 (IL-2) production over 24h in response to the toxin phytohaemagglutinin (PHA), was increased by 34% if cells were challenged
https://www.semanticscholar.org/paper/Cell-passage-associated-transient-high-oxygenation-Grant-Griffiths/9bafb804272481c95de3b6d2124506815b6cfdbf
Glutathione Depletion in Rats Impairs T-Cell and Macrophage Immune Function | JAMA Surgery | The JAMA NetworkGlutathione Depletion in Rats Impairs T-Cell and Macrophage Immune Function | JAMA Surgery | The JAMA Network
• Critical illness is associated with both immunosuppression and glutathione deficiency. We determined if in vivo depletion of glutathione would adversely affec
https://jamanetwork.com/journals/jamasurgery/article-abstract/595577?redirect=true
Difference between DEM/DTM and DSMDifference between DEM/DTM and DSM
The term DEM, DTM and DSM has several meanings and are not always understood properly, correctly or misinterpreted. Difference between DEM/DTM and DSM
https://gisresources.com/confused-dem-dtm-dsm/
Judi Bola Gelinding Judi Ayam Judi Karaoke Fundamentals Explained
Helping The others Realize The Advantages Of judi bola gelinding judi ayam judi karaoke - A Simple Key For judi bola gelinding judi ayam judi karaoke Unveiled - The best Side of judi bola gelinding judi ayam judi karaoke
https://ruangtaruhan.com/judi-bola-gelinding-judi-ayam-judi-karaoke-fundamentals-explained-20333
CHRYSO®Dem DPV Eco 1CHRYSO®Dem DPV Eco 1
CHRYSO®Dem DPV Eco 2 jest gotowym do u?ycia ?rodkiem do opó?nionego rozformowywania (antyadhezyjnym), o sk?adzie czysto ro?linnym, a zatem bezpiecznym dla u?ytkowników ...
https://www.chryso.pl/p/8106/chryso-rem-dem-dpv-eco-1
CHRYSO®Dem Eco 2 - DPVCHRYSO®Dem Eco 2 - DPV
CHRYSO®Dem Eco 2 - DPV jest gotowym do u?ycia ?rodkiem do opó?nionego rozformowywania (antyadhezyjnym), o sk?adzie czysto ro?linnym, a zatem bezpiecznym dla u?ytkowników ...
https://www.chryso.pl/p/8107/chryso-rem-dem-eco-2-dpv
Zum Koordinationsverhalten von Quecksilber(II)-Salzen unter dem Einfluss organischer Donorliganden - Kölner...Zum Koordinationsverhalten von Quecksilber(II)-Salzen unter dem Einfluss organischer Donorliganden - Kölner...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
http://kups.ub.uni-koeln.de/1379/
Biofrontera: Erfolg vor dem BundesgerichtshofBiofrontera: Erfolg vor dem Bundesgerichtshof
In einem langwierigen Prozess entscheidet der Bundesgerichtshof zugunsten von Biofrontera. Das Gericht hebt ein Urteil des Oberlandesgerichts Köln aus dem
https://www.4investors.de/nachrichten/boerse.php?sektion=stock&ID=146125
Borussia Mönchengladbach: Die Top-Elf seit dem Jahr 2000Borussia Mönchengladbach: Die Top-Elf seit dem Jahr 2000
Borussia Mönchengladbach hat sich in den vergangenen 20 Jahren von einem Abstiegskandidaten zu einer ernstzunehmenden Top-Mannschaft in Deutschland entwickelt. ran.de zeigt die beste Gladbach-Elf seit dem Jahrtausendwechsel.
https://www.ran.de/fussball/bundesliga/bildergalerien/borussia-moenchengladbach-die-top-elf-seit-dem-jahr-2000
Brage INN: Master i treningsfysiologiBrage INN: Master i treningsfysiologi
Formål: Formålet med studiet var å sjå om det er fysisk aktivitet eller fysikalsk behandling som gir størst endring i volum av lymfødem hjå personar med kreftrelatert lymfødem. Metode: Studiet var eit randomisert ...
https://brage.inn.no/inn-xmlui/handle/11250/2640292
在MetaTrader市场下载MetaTrader 4的DEM and RSI 技术指标在MetaTrader市场下载MetaTrader 4的DEM and RSI 技术指标
DEM and RSI: 此 DEM 和 RSI 指标基于两个流行指标 - DeMarker + RSI。它的工作像一个半自动交易系统，识别超卖和超买级别，给出对应的开仓信号。 交易建议: 在任意货币对的任意时间帧图表上挂载指标 (它在 EURUSD M1 图表上显示最佳)。 当此时有买/卖信号 - 中文
https://www.mql5.com/zh/market/product/3418?source=Site+Market+Product+Similar
Tribbing | Sex
Det mest effektiva Tribbing sex gallerier såväl som varm unclothed flicka mus foton är väntar på du med track down dem with enjoy minnesvärd klappa minuter seende dem online.
https://kvmrt.info/tribbing/
تحلیلی بر کارکرد و نقش عوامل طبیعی در مکان‌گزینی و گسترش کالبد‌ شهری (مطالعه موردی: شهر کامیاران)تحلیلی بر کارکرد و نقش عوامل طبیعی در مکان‌گزینی و گسترش کالبد‌ شهری (مطالعه موردی: شهر کامیاران)
توسعۀ ‌فیزیکی شهر کامیاران و چگونگی برخورد آن با واحدهای مختلف طبیعی و ژئومورفیک شامل تپه-ها، رودخانه، آبرفت-های قدیمی و خطوط گسل مسائل مهم و چالش برانگیزی را به همراه داشته است. پژوهش حاضر در پی شناخت عوامل موثر بر مکان‌گزینی و توسعه‌فیزیکی شهر و ارائه مدلی مناسب با توجه به این عوامل جهت توسعه آتی شهر کامیاران می-باشد. این پژوهش از نظر هدف کاربردی و از نظر روش، توصیفی - تحلیلی است. در این بررسی از مشاهدۀ میدانی، عکس‌های‌هوایی، تصاویر ماهواره‌ای (لندست) و DEM27 متر منطقه، جهت استخراج بخش عمده‌ای از اطلاعات و نقشه‌ها در محیط GISاستفاده شده است. مجموعه داده-ها
https://jshsp.iaurasht.ac.ir/article_543094.html
Vershon - All Fi Dem 2017 - JahknoVershon - All Fi Dem 2017 - Jahkno
By checking this box, you confirm that you have read and are agreeing to our terms of use regarding the storage of the data submitted through this form ...
https://jahkno.com/vershon-all-fi-dem-2017/
EANS-Stimmrechte: Andritz AG / Veröffentlichung einer Mitteilung gemäß § 93 BörseG mit dem Ziel der europaweiten Verbreitung |...EANS-Stimmrechte: Andritz AG / Veröffentlichung einer Mitteilung gemäß § 93 BörseG mit dem Ziel der europaweiten Verbreitung |...
-------------------------------------------------------------------------------- Stimmrechtsmitteilung übermittelt durch euro adhoc mit dem Ziel einer europaweiten Verbreitung....
https://www.presseportal.de/pm/54966/2695431
Doppelt Fermentierter Schwarzer Knoblauch Rein - Super Nature ProductsDoppelt Fermentierter Schwarzer Knoblauch Rein - Super Nature Products
Kräuterzubereitung Unser doppelt fermentierter schwarzer Knoblauch enthält die wichtige Verbindung S-Allycystein mit dem
https://www.supernatureproducts.de/product/doppelt-fermentierter-schwarzer-knoblauch-60kaps-de/
Listar Articulos(CEFYBO) por fecha de publicaciónListar Articulos(CEFYBO) por fecha de publicación
CONICET Digital, el repositorio institucional del CONICET, un servicio gratuito para acceder a la producción científico-tecnológica de investigadores, becarios y demás personal del CONICET.
https://ri.conicet.gov.ar/handle/11336/375/browse
ListarArticulos(IQUIBICEN) por temaListarArticulos(IQUIBICEN) por tema
CONICET Digital, el repositorio institucional del CONICET, un servicio gratuito para acceder a la producción científico-tecnológica de investigadores, becarios y demás personal del CONICET.
https://ri.conicet.gov.ar/handle/11336/360/browse?rpp=20&etal=-1&sort_by=-1&type=subject&starts_with=R&order=ASC
Produkte - RENNGRIBProdukte - RENNGRIB
Alle Preise inkl. der gesetzlichen MwSt.. Die durchgestrichenen Preise entsprechen dem bisherigen Preis in diesem Online-Shop.. ...
https://renngrib.de/shop/?filter_brand=pro-fiber&query_type_brand=or&source_id=163&source_tax=product_cat&product_cat=rahmenschoner&filter_filter-baujahr=2008,2006&query_type_filter-baujahr=or
Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM) | EJNMMI Research | Full...Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM) | EJNMMI Research | Full...
The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intracellular thiols. Glutathione (GSH) is the most abundant intracellular thiol, and its redox status changes in cancer cells and ischaemic myocardium (two prime applications for 64Cu(ATSM) PET). We therefore investigated whether modification of intracellular GSH content affects the hypoxia selectivity of 64Cu(ATSM). Isolated rat hearts (n = five per group) were perfused with aerobic buffer (equilibrated with 95%O2/5%CO2) for 15 min, then hypoxic buffer (95%N2/5%CO2) for 20 min. Cardiac glutathione was depleted by buthionine sulphoximine (BSO, 4 mmol/kg/ 48 h intraperitoneal), or augmented by N-acetyl cysteine (NAC, 4 mmol/L) in the perfusion buffer. Cardiac 64Cu retention from three 2-MBq bolus injections of 64Cu(ATSM) before and during hypoxia was then monitored by NaI detectors. Cardiac GSH content
https://ejnmmires.springeropen.com/articles/10.1186/s13550-014-0040-8
Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin...Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin...
The effect of photodynamic therapy (PDT) on neurons is of critical importance when treating cancers within or adjacent to the nervous system. Neurons show reduced sensitivity to meta-tetrahydroxyphenyl chlorin (mTHPC) mediated PDT, so the aim of this study was to investigate whether neuron sparing is due to endogenous cellular antioxidant activity. Dorsal root ganglion (DRG) neurons and their associated satellite glia were subjected to mTHPC-PDT in a 3D co-culture system following incubation with antioxidant inhibitors: diethyl dithiocarbamate (DDC, SOD-1 inhibitor), 2-methoxyestradiol (2-MeOH2, SOD-2 inhibitor) and l-buthionine sulfoximine (l-BSO, glutathione synthase inhibitor). Sensitivity of each cell type was assessed using a combination of live/dead staining and immunofluorescence. Pretreatment with DDC and with l-BSO significantly increased the sensitivity of neurons to mTHPC-PDT and also affected satellite glial cell viability, whereas 2-MeOE2 caused only a small increase in neuron ...
http://oro.open.ac.uk/33981/
Protective effect of glutathione on the cytotoxicity caused by a combination of aluminum and iron in suspension-cultured...
TY - JOUR. T1 - Protective effect of glutathione on the cytotoxicity caused by a combination of aluminum and iron in suspension-cultured tobacco cells. AU - Yamaguchi, Yukiko. AU - Yamamoto, Yoko. AU - Ikegawa, Hiroshi. AU - Matsumoto, Hideaki. PY - 1999/3. Y1 - 1999/3. N2 - The role of endogenous glutathione (GSH) in the protection of suspension-cultured tobacco cells from aluminum (Al) toxicity was examined. Cells at the logarithmic phase of growth were treated with or without A1 in nutrient medium prepared without P(i) and EDTA. In the absence of A1, total GSH content (including oxidized glutathione [GSSG]) increased gradually. In the presence of Al, the increase of GSH was repressed. This effect was observed before the loss of plasma membrane integrity and the loss of cell viability. In contrast, GSSG content in cells increased in the presence of A1. GSH-deprived cells were prepared by culturing cells with buthionine sulfoximine (an inhibitor of γ-glutamylcysteine synthetase) for 24 h. ...
https://okayama.pure.elsevier.com/en/publications/protective-effect-of-glutathione-on-the-cytotoxicity-caused-by-a-
Immunoregulatory Effects of Glutathione During Mesenchymal Stem Cell Differentiation to Hepatocyte-Like CellsImmunoregulatory Effects of Glutathione During Mesenchymal Stem Cell Differentiation to Hepatocyte-Like Cells
Background: The role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. The differentiation potential of MSCs and abilities in modulations of the recipients immune system makes them important cells in tissue regenerative studies. MSCs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling pathways for releasing of these mediators are not well understood. Glutathione has been shown to play a role in modulation of cytokines in hepatogenic differentiation. Objective: In the current study we aimed to investigate the effects of buthionine sulfoximine (BSO, inhibitor for glutathione synthesis) and N-acetylecystin (NAC, an inhibitor for ROS generation) on proinflammatory cytokines production in a hepatogenic differentiation model. Results: BSO and NAC significantly decreased IL-6 and TNF-α levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation.
http://iji.sums.ac.ir/article_16870.html
Arsenic trioxide in ovarian cancer | ScholarBank@NUSArsenic trioxide in ovarian cancer | [email protected]
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of arsenic-resistant OVCAR-3 (OVCAR-3/AsR) cells showed the involvement of multiple factors mediating its chemoresistance. Of particular interest, a genetic hub involving elevated interleukin 1A signalling was identified. This could consecutively modulate the ...
http://scholarbank.nus.edu.sg/handle/10635/28135
Glutamate-Cysteine Ligase | Profiles RNS
Villablanca JG, Volchenboum SL, Cho H, Kang MH, Cohn SL, Anderson CP, Marachelian A, Groshen S, Tsao-Wei D, Matthay KK, Maris JM, Hasenauer CE, Czarnecki S, Lai H, Goodarzian F, Shimada H, Reynolds CP. A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 08; 63(8):1349-56 ...
https://profiles.uchicago.edu/profiles/display/12809
Plus itPlus it
The pathophysiology of hepatic veno-occlusive disease is poorly understood. These studies were undertaken to determine the initial cellular target and the role of glutathione detoxification of dacarbazine, a toxin implicated in hepatic veno-occlusive disease. Sinusoidal endothelial cells (SECs) and hepatocytes were isolated and plated in culture dishes. Dacarbazine (5-(3,3-dimethyl-triazeno) imidazole-4-carboxamide), 3 and 6 mM, was toxic to SECs but not to hepatocytes. Onset of toxicity occurred between 11 and 12 hr as determined by serial MTT assays and ethidium homodimer dye exclusion. Glutathione detoxification of dacarbazine in SECs was suggested by: (1) depletion of glutathione before onset of toxicity; (2) exacerbation of toxicity by buthionine sulfoximine (BSO) depletion of glutathione; and (3) protection by exogenous glutathione. Protection by exogenous glutathione may be by uptake of intact tripeptide rather than by extracellular hydrolysis: neither acivicin (inhibitor of ...
https://jpet.aspetjournals.org/content/268/3/1261
August | 2018 | Mdm2 Pathway
For the studies using the isPRL model in anesthetized rats, UDCA was administered through the femoral vein to (1) normal Wistar rats (40, 60, and 80 μmol/hour), (2) rats with. depletion of liver glutathione after 2 days of treatment with buthionine sulfoximine (BSO; Sigma; UDCA at 80 μmol/hour), and (3) ABCC2/Mrp2-deficient [transport mutant (TR−)] rats (UDCA at 80 μmol/hour). For specificity experiments, either cholic acid (CA) or tauroursodeoxycholic acid (TUDCA) was administered (80 μmol/hour each) instead of UDCA. To assess the direct effect of GSNO on biliary epithelium, this compound was injected through the common bile duct of isPRLs. At the end of the experiments, blood was extracted selleck products from the portal vein, and animals were sacrificed, the liver and the common bile duct both being stored at −80°C until use. Inhibition of NO synthesis was. assessed selleck chemicals with the IPRL model by the infusion of UDCA in the presence or absence of the NOS inhibitor ...
https://mdmpathway.com/2018/08/
A Zebrafish Assay for Identifying Neuroprotectants in vivo by Chuenlei Parng, Christopher Ton et al.A Zebrafish Assay for Identifying Neuroprotectants in vivo by Chuenlei Parng, Christopher Ton et al.
In this study, we developed an in vivo method to determine drug effects on oxidation-induced apoptosis in the zebrafish brain caused by treatment with l-hydroxyglutaric acid (LGA). We confirmed that LGA-induced apoptosis was caused by oxidation by examining the presence of an oxidative product, nitrotyrosine. Next, we examined the effects of 14 characterized neuroprotectants on LGA-treated zebrafish, including: d-methione (d-Met), Indole-3-carbinol, deferoxamine (DFO), dihydroxybenzoate (DHB), deprenyl, l-NAME (N(G)-nitro-l-arginine methyl ester), n-acetyl l-cysteine (l-NAC), 2-oxothiazolidine-4-carboxylate (OTC), lipoic acid, minocycline, isatin, cortisone, ascorbic acid and α-tocopherol. Eleven of 14 neuroprotectants and 7 of 7 synthetic anti-oxidants exhibit significant protection in zebrafish. Buthionine sulfoximine (BSO), used as a negative control, exhibited no significant protective effects. In addition, three blood-brain barrier (BBB) impermeable compounds exhibited no significant effects. Our
http://digitalcommons.sacredheart.edu/bio_fac/86/
Glutathione Deficiency. How to treat it. Causes of. How to increase.Glutathione Deficiency. How to treat it. Causes of. How to increase.
Glutathione deficiency can still be treated and restored to satisfactory levels once again. Knowing how to increase the glutathione in your body is the first step.
https://www.kellersformula.com/glutathione-deficiency/
Dopamine toxicity in neuroblastoma cells: Role of glutathione depletion by L-BSO and apoptosis<...
TY - JOUR. T1 - Dopamine toxicity in neuroblastoma cells. T2 - Role of glutathione depletion by L-BSO and apoptosis. AU - Stokes, Alan H.. AU - Lewis, Denise Y.. AU - Lash, Lawrence H.. AU - Gray Jerome, W.. AU - Grant, Ken W.. AU - Aschner, Michael. AU - Vrana, Kent E.. N1 - Funding Information: This work was supported by grants GM 38931 (KEV) and T32 DA 07246 (AHS). PY - 2000. Y1 - 2000. N2 - Dopamine (DA), while an essential neurotransmitter, is also a known neurotoxin that potentially plays an etiologic role in several neurodegenerative diseases. DA metabolism and oxidation readily produce reactive oxygen species (ROS) and DA can also be oxidized to a reactive quinone via spontaneous, enzyme-catalyzed or metal-enhanced reactions. A number of these reactions are cytotoxic, yet the precise mechanisms by which DA leads to cell death remain unknown. In this study, the neuroblastoma cell line, SK-N-SH, was utilized to examine DA toxicity under varying oxidant states. Cells pretreated with the ...
https://pennstate.pure.elsevier.com/en/publications/dopamine-toxicity-in-neuroblastoma-cells-role-of-glutathione-depl
Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD. - MRC Weatherall...
The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. The aim of this study was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN protein expression was measured in the peripheral lung of COPD patients compared with smoking and nonsmoking controls. The direct influence of cigarette smoke extract (CSE) on PTEN expression was assessed using primary lung epithelial cells and a cell line (BEAS-2B) in the presence or absence of l-buthionine-sulfoximine (BSO) to deplete intracellular glutathione. The impact of PTEN knockdown by RNA interference on cytokine production was also examined. In peripheral lung, PTEN protein was significantly decreased in patients with COPD compared with the subjects without COPD (P | 0.001) and positively correlated with the severity of airflow
https://www.imm.ox.ac.uk/publications/826139
Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro -...Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro -...
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., ...
https://research.aston.ac.uk/portal/en/researchoutput/sulforaphane-restores-cellular-glutathione-levels-and-reduces-chronic-periodontitis-neutrophil-hyperactivity-in-vitro
Do You Have a Glutathione Deficiency? - Core Med ScienceDo You Have a Glutathione Deficiency? - Core Med Science
Glutathione plays a pivotal role in many key metabolic reactions in your body. Each of your cells contains glutathione, a substance created from three amino acids: cysteine, glutamate, and glycine. The bodys
https://coremedscience.com/blogs/wellness/do-you-have-a-glutathione-deficiency
publish.UP Searchpublish.UP Search
This study aims to further mechanistically understand toxic modes of action after chronic inorganic arsenic exposure. Therefore long-term incubation studies in cultured cells were carried out, to display chronically attained changes, which cannot be observed in the generally applied in vitro short-term incubation studies. Particularly, the cytotoxic, genotoxic and epigenetic effects of an up to 21 days incubation of human urothelial (UROtsa) cells with pico- to nanomolar concentrations of iAsIII and its metabolite thio-DMAV were compared. After 21 days of incubation, cytotoxic effects were strongly enhanced in the case of iAsIII and might partly be due to glutathione depletion and genotoxic effects on the chromosomal level. These results are in strong contrast to cells exposed to thio-DMAV. Thus, cells seemed to be able to adapt to this arsenical, as indicated among others by an increase in the cellular glutathione level. Most interestingly, picomolar concentrations of both iAsIII and thio-DMAV ...
https://publishup.uni-potsdam.de/opus4-ubp/solrsearch/index/search/searchtype/authorsearch/author/Larissa+Leffers/start/0/rows/100/subjectfq/gene-expression/doctypefq/article
urlaub auf dem bauernhof bayern
Wann machen Sie mit Ihrer Familie Urlaub auf dem Bayern Bauernhof im Bayerischen Wald ? Reservations longer than 30 nights are not possible. If your plans change, you can cancel free of charge until free cancellation expires. Urlaub auf dem Bauernhof - Ludwig Blöchl Eggerlhof takes special requests - add in the next step! Localities in the … Search. Theres no capacity for cribs at this property. Ruhe, Natur und Genuss finden Sie in einem Urlaub auf dem Landhof und Entspannung auf einem Gesundheits- und Wellnesshof. Wurmannsquick, Bayern, ab 75 € Travel might only be permitted for certain purposes, and touristic travel in particular may not be allowed. Urlaub auf dem Bauernhof bieten in Bayern über 4.000 landwirtschaftliche Betriebe an. Urlaub auf dem Bauernhof ist DAS touristische Erfolgsmodell unserer schnelllebigen Zeit! Nov 26, 2020 - Entire home/apt for $74. Something went wrong - please try again later. bauernhof-in-bayern.com +49 8584 478; Overview: Map: Photo Map: Satellite: ...
https://www.psychotherapiepraxis-ffm.de/uiqx6l2/dtuv1x.php?902c7d=urlaub-auf-dem-bauernhof-bayern
View Profile: WilliamArpiss - Lapak Betting, Forum Agen Bola, Forum Prediksi Bola, Judi Bola, Taruhan BolaView Profile: WilliamArpiss - Lapak Betting, Forum Agen Bola, Forum Prediksi Bola, Judi Bola, Taruhan Bola
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http://lapakbetting.com/member.php/161679-WilliamArpiss?s=345029a2852f2f2c3faba2551999c0a2
View Profile: johnnyped - Lapak Betting, Forum Agen Bola, Forum Prediksi Bola, Judi Bola, Taruhan BolaView Profile: johnnyped - Lapak Betting, Forum Agen Bola, Forum Prediksi Bola, Judi Bola, Taruhan Bola
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http://lapakbetting.com/member.php/65598-johnnyped?s=adc65eb914506b858785350cd1496eaa
Sbobet88 situs judi bola deposit pulsa | Mission DiscipleshipSbobet88 situs judi bola deposit pulsa | Mission Discipleship
Sbobet88 - Benar-benar harus kita akui bahwa seorang itu terkadang memang membutuhkan penyegaran otak, jalan satu-satunya yakni dengan menyempatkan diri untuk bertaruh di judi bola online. Tetapi lewat cara bertaruh ini bukan di sarankan kepada orang yang sering kalah dalam taruhan bola online di internet. Seseorang dapat mengalami stress berlebihan dikala ia harus main taruhan sepak bola senantiasa kalah. Lantas, apa cara terbaik utk memasang sbobet Bandar bola agar bisa menang terus? Yuk, mari kita simak ulasan yang akan kami berikan di bawah ini bersama.. Cara Menang Judi Bola Over/ ...
https://missiondiscipleship.org/forums/topic/sbobet88-situs-judi-bola-deposit-pulsa/?bbp_reply_to=288483&_wpnonce=143605774b
Sbobet88 situs judi bola deposit pulsa | Mission DiscipleshipSbobet88 situs judi bola deposit pulsa | Mission Discipleship
Sbobet88 - Benar-benar harus kita akui bahwa seorang itu terkadang memang membutuhkan penyegaran otak, jalan satu-satunya yakni dengan menyempatkan diri untuk bertaruh di judi bola online. Tetapi lewat cara bertaruh ini bukan di sarankan kepada orang yang sering kalah dalam taruhan bola online di internet. Seseorang dapat mengalami stress berlebihan dikala ia harus main taruhan sepak bola senantiasa kalah. Lantas, apa cara terbaik utk memasang sbobet Bandar bola agar bisa menang terus? Yuk, mari kita simak ulasan yang akan kami berikan di bawah ini bersama.. Cara Menang Judi Bola Over/ ...
https://missiondiscipleship.org/forums/topic/sbobet88-situs-judi-bola-deposit-pulsa/?bbp_reply_to=286679&_wpnonce=60fc567396
Designing Heavy Equipment using Rocky DEM Simulation - Rocky DEMDesigning Heavy Equipment using Rocky DEM Simulation - Rocky DEM
Answer your questions about predicting bulk material behavior and show you how to use Rocky DEM in your heavy equipment design processes, giving you crucial insights.
https://rocky.esss.co/library/webinar-heavy-equipment/
Vereinbarkeit mit dem Grundrecht der Rundfunkfreiheit in ihrer speziellen Ausprägung als Programmfreiheit gemäß Art. 5 Abs. 1 S...Vereinbarkeit mit dem Grundrecht der Rundfunkfreiheit in ihrer speziellen Ausprägung als Programmfreiheit gemäß Art. 5 Abs. 1 S...
eBook: Vereinbarkeit mit dem Grundrecht der Rundfunkfreiheit in ihrer speziellen Ausprägung als Programmfreiheit gemäß Art. 5 Abs. 1 S. 2 GG (ISBN 978-3-8329-4013-3) von aus dem Jahr 2008
https://www.nomos-elibrary.de/84857/vereinbarkeit-mit-dem-grundrecht-der-rundfunkfreiheit-in-ihrer-speziellen-auspraegung-als-programmfreiheit-gemaess-art-5-abs-1-s-2-gg
Alloggio Bělá pod Pradědem (9) Alberghi Bělá pod Pradědem Prenotazione online hotel Repubblica Ceca
Alloggio Bělá pod Pradědem. Una vasta offerta di sistemazioni - prenotazioni online. Hotel, pensioni, chalet, appartamenti privati, ricovero, motel e botel. Cominciare dagli alloggi più economici e con prezzi più bassi sino agli hotel più esclusivi. Repubblica Ceca.
http://bela-pod-pradedem.czech-republic.topdestination.it/?page=1
Hva er akrylamider og hvorfor skal vi være bekymret for dem? / What are acrylamides and why should w | helsegevinstHva er akrylamider og hvorfor skal vi være bekymret for dem? / What are acrylamides and why should w | helsegevinst
Er bakte poteter og bakt søte poteter trygt å spise? Hva er akrylamider og hvorfor skal vi være bekymret for dem? Er det en kreftrisiko med stekt, ristet ell...
http://www.helsegevinst.no/2017/08/11/nb-NO/hva-er-akrylamider-og-hvorfor-skal-vi-v%C3%A6re-bekymret-for-dem-%C2%A0what-are-acrylamides-and-why-should-w-37089761
Suche dieses Addon aus dem VideoSuche dieses Addon aus dem Video
Suche aus dem Video das Addon was die hexer ja auch haben dieses Necrosis gibts auch f r mages nur wusste ned wie des hei en k nnte F r Magier gibts 2
https://www.elitepvpers.com/forum/wow-addons/60706-suche-dieses-addon-aus-dem-video.html
Highlights aus dem Helmholtz-Zentrum Dresden-Rossendorf (HZDR) 2010, Highlights aus der ForschungHighlights aus dem Helmholtz-Zentrum Dresden-Rossendorf (HZDR) 2010, Highlights aus der Forschung
Highlights aus dem Helmholtz-Zentrum Dresden-Rossendorf (HZDR) 2010, Inhalt, Ueberblick, Investitionen in die Zukunft - Grusswort des Vorstands, Ereignischronik 2010, Highlights aus der Forschung, Zukunftsprojekte, Nachwuchs, Wissens- und Technologietransfer, Preise - Rufe - Personalia, Impressum
https://www.hzdr.de/db/Cms?pOid=33396&pNid=2134&pContLang=en
2010-2011 NBA Preview: Western Conference | BSO2010-2011 NBA Preview: Western Conference | BSO
FINALLY! Tonight at 8:00 PM eastern time, the most anticipated season in NBA history kicks off as the Boston Celtics host the Miami Heat and their new Big Three
http://blacksportsonline.com/home/2010/10/2010-2011-nba-preview-western-conference/comment-page-1/
Gliazellen neurotrophischer Faktor
Das GDNF-Gen kodiert einen von Glia-Zellen gebildeten neutrotrophischen Faktor der zusammen mit dem Produkt des RET-Gens die Bildung und Apoptose von Nervenzellen steuert. Mutationen führen zu verschiedenen autosomal dominanten Erkrankungen, dem zentralen Hypoventilationssyndrom, der Hirschsprung-Erkrankung und dem Phäochromozytom.. ...
http://www.moldiag.com/moldiag/de/id/G0428
Lexikon der Nachhaltigkeit | Politik | UN Konferenzen: ÜbersichtLexikon der Nachhaltigkeit | Politik | UN Konferenzen: Übersicht
EinleitungDie Vereinten Nationen spielen seit Jahren eine der wichtigsten Rollen im internationalen Umweltschutz. Nach dem Weltgipfel in Rio entstanden eine ganze Reihe von Programmen und Organisationen, die sich mit dem internationalen Umweltschutz beschäftigen. Die aus dem Weltgipfel resultierenden Konventionen und Protokolle werden in Folgekonferenzen überwacht und weiterentwickelt.
https://www.nachhaltigkeit.info/artikel/un_konferenzen_1435.htm?sid=sp97qkefp2org38b0iin843hj0
EWL Campaign Clip For a Change of Perspective in (...)EWL Campaign Clip For a Change of Perspective in (...)
Wenn ich zehnmal am Tag mit Fremden Sex haben müsste, um zu überleben, ab dem wievielten Mal würde mir dabei übel werden? Bestimmt ab dem ersten Mal.
https://womenlobby.org/EWL-Campaign-Clip-For-a-Change-of-Perspective-in-German
Dantzig, Die Hauptstatt In dem Koniglich Polnischen Preussen - Barry Lawrence Ruderman Antique Maps Inc.Dantzig, Die Hauptstatt In dem Koniglich Polnischen Preussen - Barry Lawrence Ruderman Antique Maps Inc.
Striking view of the City of Dantzig, but Gabriel Bodenehr in Augsburg. Includes a key and explanation of the City in the margins.
https://www.raremaps.com/gallery/detail/22561/dantzig-die-hauptstatt-in-dem-koniglich-polnischen-preussen-bodenehr
Grichisch
Die Jungs vom GLOBUS Supermarkt sind echte Garanten für lustige Schreibfehler. Das heutige Fundstück stammt aus dem Globus in Koblenz, in dem Grichische
http://www.fehlerleser.de/2010/02/grichisch/?replytocom=674528
Grichisch
Die Jungs vom GLOBUS Supermarkt sind echte Garanten für lustige Schreibfehler. Das heutige Fundstück stammt aus dem Globus in Koblenz, in dem Grichische
http://www.fehlerleser.de/2010/02/grichisch/?replytocom=668202
Lipgloss Geschenkset von bareMinerals | parfumdreamsLipgloss Geschenkset von bareMinerals | parfumdreams
In dem praktischen Lipgloss Geschenkset aus dem Kosmetikhaus bareMinerals finden Damen zwei hochwertige Lippenfarben, die der Haut eine große Portion Feuchtigkeit spenden. Neben einem Gloss Gen Nude M
https://www.parfumdreams.de/bareMinerals/Lippen-Make-up/Lipgloss/Geschenkset/index_95552.aspx
Notfall Angio demNotfall Angio dem
Die Diagnostik und Behandlung von akuten Angio demen ist anspruchsvoll. Es handelt sich um klinisch leicht verwechselbare Krankheitsbilder, die aufgrund unterschiedlicher pathophysiologischer Mechanismen entstehen. Zu den ausl senden Faktoren z hlen...
https://www.aerzteblatt.de/archiv/192555/Notfall-Angiooedem
Bürgerwelle News
Wenn du auf dem Klo sitzt und nicht weisst, was du ohne dein Handy mit dem Leben...3. Wenn dein Handy einen Ehrenplatz in deinem Bett hat ...
http://www.buergerwelle.de:8080/helma/twoday/bwnews/month?date=201606
Verwertungskündigung | RechtslupeVerwertungskündigung | Rechtslupe
Unter wel-chen Vor-aus-set-zun-gen ist die Kün-di-gung eines Wohn-raum-miet-ver-hält-nis-ses wegen beab-sich-tig-ter wirt-schaft-li-cher Ver-wer-tung des Grund-stücks nach § 573 Abs. 2 Nr. 3 BGB (hier: zur Erwei-te-rung eines benach-bar-ten Mode-hau-ses) wirk-sam? Mit die-ser Fra-ge hat-te sich aktu-ell der Bun-des-ge-richts-hof zu befas-sen: Anlass hier-für bot ihm ein Fall aus dem Schwarz-wald: Die Mie-ter haben im. Lesen ...
https://www.rechtslupe.de/stichworte/verwertungskuendigung
Buthionine sulfoximineButhionine sulfoximine
... (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an ... Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs. Defty, CL; ... "Definition of buthionine sulfoximine - National Cancer Institute Drug Dictionary". 2011-02-02. v t e (Articles without KEGG ... Sulfoximines, All stub articles, Organic compound stubs). ...
https://en.wikipedia.org/wiki/Buthionine_sulfoximine
Reactive oxygen speciesReactive oxygen species
... buthionine sulfoximine (BSO)). The result is an overall increase in endogenous ROS, which when above a cellular tolerability ...
https://en.wikipedia.org/wiki/Reactive_oxygen_species
Glutamate-cysteine ligaseGlutamate-cysteine ligase
"Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)". J Biol ...
https://en.wikipedia.org/wiki/Glutamate–cysteine_ligase
11-Ketoprogesterone11-Ketoprogesterone
Piwien-Pilipuk G, Galigniana MD (2000). "Oxidative stress induced by L-buthionine-(S,R)-sulfoximine, a selective inhibitor of ...
https://en.wikipedia.org/wiki/11-Ketoprogesterone
S-NitrosoglutathioneS-Nitrosoglutathione
... inhibition of iNOS with L-NAME in isolated perfused livers and also in rat livers depleted of GSH with buthionine sulfoximine. ...
https://en.wikipedia.org/wiki/S-Nitrosoglutathione
BSOBSO
... and oxygen Buthionine sulfoximine, a chemical substance inhibiting glutathione synthesis Brain storm optimization algorithm ...
https://en.wikipedia.org/wiki/BSO
List of MeSH codes (D12.125)List of MeSH codes (D12.125)
... methionine sulfoximine MeSH D12.125.166.676.620.125 - buthionine sulfoximine MeSH D12.125.166.676.900 - selenomethionine MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.125)
Experimental models of Alzheimers diseaseExperimental models of Alzheimer's disease
Buthionine sulfoximine + amyloid beta (FAB) Glutamic acid (glutamate) N-Methyl-D-aspartic acid and NMDA receptors Onos KD, Uyar ...
https://en.wikipedia.org/wiki/Experimental_models_of_Alzheimer's_disease
List of MeSH codes (D02)List of MeSH codes (D02)
... methionine sulfoximine MeSH D02.886.030.676.620.125 - buthionine sulfoximine MeSH D02.886.030.676.900 - selenomethionine MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Index of oncology articlesIndex of oncology articles
... buthionine sulfoximine C cell - c-erbB-2 - c-kit - CA 19-9 assay - CA-125 - CA-125 test - cachexia - calcitonin - calcitriol - ...
https://en.wikipedia.org/wiki/Index_of_oncology_articles
Luca ShytajLuca Shytaj
Buthionine Sulfoximine and Suppressive Antiretroviral Therapy Induce Post-Therapy Control of Viremia in Chronically SIVmac251 ...
https://en.wikipedia.org/wiki/Luca_Shytaj
2014 Ju-Jitsu World Championships2014 Ju-Jitsu World Championships
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
https://en.wikipedia.org/wiki/2014_Ju-Jitsu_World_Championships
Bolley JohnsonBolley Johnson
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
https://en.wikipedia.org/wiki/Bolley_Johnson
Dont Say NoDon't Say No
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
https://en.wikipedia.org/wiki/Don't_Say_No
Dewoitine D.371Dewoitine D.371
The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...
https://en.wikipedia.org/wiki/Dewoitine_D.371
Noor-ul-AinNoor-ul-Ain
The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...
https://en.wikipedia.org/wiki/Noor-ul-Ain
Benoist Land Tractor Type XIIBenoist Land Tractor Type XII
The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...
https://en.wikipedia.org/wiki/Benoist_Land_Tractor_Type_XII
Santa Cruz BarillasSanta Cruz Barillas
... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...
https://en.wikipedia.org/wiki/Santa_Cruz_Barillas
Maria Margaret PollenMaria Margaret Pollen
Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...
https://en.wikipedia.org/wiki/Maria_Margaret_Pollen
Ronald FoglemanRonald Fogleman
Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...
https://en.wikipedia.org/wiki/Ronald_Fogleman
Peachtree Street (song)Peachtree Street (song)
Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...
https://en.wikipedia.org/wiki/Peachtree_Street_(song)
We, Too, Have a Job to DoWe, Too, Have a Job to Do
... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...
https://en.wikipedia.org/wiki/We,_Too,_Have_a_Job_to_Do
2021 Akkar explosion2021 Akkar explosion
At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...
https://en.wikipedia.org/wiki/2021_Akkar_explosion
Straubing TigersStraubing Tigers
The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...
https://en.wikipedia.org/wiki/Straubing_Tigers
Leina, Saare CountyLeina, Saare County
Leina is a village in Saaremaa Parish, Saare County in western Estonia. Before the administrative reform in 2017, the village was in Pihtla Parish. "Lisa. Asustusüksuste nimistu" (PDF). haldusreform.fin.ee (in Estonian). Rahandusministeerium. Retrieved 5 December 2017. "Saaremaa külad endiste valdade piires". www.saaremaa.ee (in Estonian). Archived from the original on 3 December 2017. Retrieved 5 December 2017. Coordinates: 58°17′10″N 22°46′26″E / 58.28611°N 22.77389°E / 58.28611; 22.77389 v t e (CS1 Estonian-language sources (et), Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Saaremaa Parish, Coordinates on Wikidata, Villages in Saare County, All stub articles, Saare County geography stubs ...
https://en.wikipedia.org/wiki/Leina,_Saare_County
SestiereSestiere
A sestiere (plural: sestieri) is a subdivision of certain Italian towns and cities. The word is from sesto ('sixth'), so it is thus used only for towns divided into six districts. The best-known example is the sestieri of Venice, but Ascoli Piceno, Genoa, Milan and Rapallo, for example, were also divided into sestieri. The medieval Lordship of Negroponte, on the island of Euboea, was also at times divided into six districts, each with a separate ruler, through the arbitration of Venice, which were known as sestieri. The island of Crete, a Venetian colony (the "Kingdom of Candia") from the Fourth Crusade, was also divided into six parts, named after the sestieri of Venice herself, while the capital Candia retained the status of a comune of Venice. The island of Burano north of Venice is also subdivided into sestieri. A variation of the word is occasionally found: the comune of Leonessa, for example, is divided into sesti or sixths. Other Italian towns with fewer than six official districts are ...
https://en.wikipedia.org/wiki/Sestiere
Island ImageIsland Image
The Island Image is a Chesapeake Bay log canoe, built in 1885 at Elliot's Island, Maryland, by Herman Jones and Isaac Moore. She is 29'-8½" long with a beam of 5-10¼", and has a straight, raking stem and a sharp stern. It is privately owned, and races under No. 17. She one of the last 22 surviving traditional Chesapeake Bay racing log canoes that carry on a tradition of racing on the Eastern Shore of Maryland that has existed since the 1840s. She is located at Chestertown, Kent County, Maryland. She was listed on the National Register of Historic Places in 1985. "National Register Information System". National Register of Historic Places. National Park Service. April 15, 2008. "Maryland Historical Trust". ISLAND IMAGE (log canoe). Maryland Historical Trust. 2008-06-14. "Island Image #17 , CBLCSA". Island Image. Chesapeake Bay Log Sailing Canoe Association. 2010-07-24. Archived from the original on 2011-07-08. Retrieved 2010-07-29. ISLAND IMAGE (log canoe), Kent County, including photo in 1984, ...
https://en.wikipedia.org/wiki/Island_Image
Bord Khun Rural DistrictBord Khun Rural District
... (Persian: دهستان بردخون) is a rural district (dehestan) in the Bord Khun District of Deyr County, Bushehr Province, Iran. At the 2006 census, its population was 1,115, in 234 families. The rural district has 14 villages. "Census of the Islamic Republic of Iran, 1385 (2006)" (Excel). Statistical Center of Iran. Archived from the original on 2011-11-11. Coordinates: 27°58′N 51°32′E / 27.967°N 51.533°E / 27.967; 51.533 v t e (Articles with short description, Short description matches Wikidata, Pages using infobox settlement with no map, Pages using infobox settlement with no coordinates, Articles containing Persian-language text, Coordinates on Wikidata, Rural Districts of Bushehr Province, Deyr County, All stub articles, Deyr County geography stubs ...
https://en.wikipedia.org/wiki/Bord_Khun_Rural_District
CamelpoxCamelpox
... is a disease of camels caused by the camelpox virus (CMPV) of the family Poxviridae, subfamily Chordopoxvirinae, and the genus Orthopoxvirus. It causes skin lesions and a generalized infection. Approximately 25% of young camels that become infected will die from the disease, while infection in older camels is generally more mild. Although rare, the infection may spread to the hands of those that work closely with camels. The camelpox virus that causes camelpox is an orthopoxvirus that is very closely related to the variola virus that causes smallpox. It is a large, brick-shaped, enveloped virus that ranges in size from 265-295 nm. The viral genetic material is contained in a linear double-stranded DNA consisting of 202,182 tightly packed base pairs. The DNA is encased in the viral core. Two lateral bodies are found outside the viral core, and are believed to hold the enzymes required for viral reproduction. The camelpox virus most often affects members of family Camelidae. However, ...
https://en.wikipedia.org/wiki/Camelpox
PheasantPheasant
... s (/ˈfɛzənt/ FEH-zənt) are birds of several genera within the family Phasianidae in the order Galliformes. Although they can be found all over the world in introduced (and captive) populations, the pheasant genera native range is restricted to Eurasia. The classification "pheasant" is paraphyletic, as birds referred to as pheasants are included within both the subfamilies Phasianinae and Pavoninae, and in many cases are more closely related to smaller phasianids, grouse, and turkey (formerly classified in Perdicinae, Tetraoninae, and Meleagridinae) than to other pheasants. Pheasants are characterised by strong sexual dimorphism, males being highly decorated with bright colours and adornments such as wattles. Males are usually larger than females and have longer tails. Males play no part in rearing the young. A pheasants call or cry can be recognised due to the fact it sounds like a rusty sink or valve being turned. Pheasants eat mostly seeds, grains, roots, and berries, while in the ...
https://en.wikipedia.org/wiki/Pheasant
L -Buthionine-sulfoximine = 97 TLC 83730-53-4
L-Buthionine-sulfoximine (L-BSO); ,= 97% TLC; This compound is also offered as part of Sigma′s Library of Pharmacologically ... L-Buthionine-sulfoximine has been used:. *as a selective activator for the induction of ferroptosis in rat apoptotic cells ...
https://wwwqws.sigmaaldrich.com/US/en/product/sigma/b2515
NIOSHTIC-2 Search Results - Full View
Oral supplementation of l-buthionine-(S,R)-sulfoximine (BSO) inhibited glutathione synthesis. Dorsiflexor muscles in the ... L-Buthionine-(S,R)-sulfoximine; Muscle; Oxidative stress; Stretch-shortening contraction ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&f1=TI&Startyear=&t1=1&s2=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=183&RecNo=1828&View=f&
IJMS | Free Full-Text | Glutathione Plays a Positive Role in the Proliferation of Pinus koraiensis Embryogenic CellsIJMS | Free Full-Text | Glutathione Plays a Positive Role in the Proliferation of Pinus koraiensis Embryogenic Cells
Exogenous glutathione and its synthase inhibitor L-buthionine-sulfoximine treatment assay demonstrated the positive role of ... 2.5.3. Validation of the Effect of Exogenous GSH and L-Buthionine-Sulfoximine (BSO) on the EC Proliferation Rate of F and S ... Exogenous glutathione and its synthase inhibitor L-buthionine-sulfoximine treatment assay demonstrated the positive role of ...
https://www.mdpi.com/1422-0067/23/23/14679/htm
Ácido alfa lipoico: MedlinePlus suplementosÁcido alfa lipoico: MedlinePlus suplementos
Maitra, I., Serbinova, E., Trischler, H., and Packer, L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract ...
https://medlineplus.gov/spanish/druginfo/natural/767.html
Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell InjuryCurcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury
exposed curcumin-pretreated N27 cells to buthionine sulfoximine and observed the upregulation of GSH and glutathione S- ...
https://www.hindawi.com/journals/prm/2019/3173149/
Effect of glutathione depletion on Leydig cell steroidogenesis in young and old Brown Norway rats<...
Incubation of Leydig cells isolated from the testes of adult Brown Norway rats with buthionine sulfoximine (BSO) reduced GSH ... Incubation of Leydig cells isolated from the testes of adult Brown Norway rats with buthionine sulfoximine (BSO) reduced GSH ... Incubation of Leydig cells isolated from the testes of adult Brown Norway rats with buthionine sulfoximine (BSO) reduced GSH ... Incubation of Leydig cells isolated from the testes of adult Brown Norway rats with buthionine sulfoximine (BSO) reduced GSH ...
https://jhu.pure.elsevier.com/en/publications/effect-of-glutathione-depletion-on-leydig-cell-steroidogenesis-in-5
Plus itPlus it
... we depleted cellular glutathione with 10 μm buthionine sulfoximine (BSO) (Jha et al., 2000) before rotenone exposure. Although ...
https://www.jneurosci.org/content/23/34/10756
PDF) Glutathione Metabolism and Its Implications for HealthPDF) Glutathione Metabolism and Its Implications for Health
... following the depletion of intracellular GSH with buthionine sulfoximine. This increase in Sx(C)- triggered by GSH depletion ...
https://www.researchgate.net/publication/6686626_Glutathione_Metabolism_and_Its_Implications_for_Health
Find Research outputs - Discovery - the University of Dundee Research Portal
Registration Dossier - ECHARegistration Dossier - ECHA
Buthionine sulfoximine at 25 μM reduced glutatione levels to about 1% of control values, and increased chromium(V) levels by ...
https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/15319/7/2/1
Publication : USDA ARSPublication : USDA ARS
L-buthionine sulfoximine, nicotine, surfactin from Bacillus subtilis, SilverDYNE®, colloidal silver, EBI-601, and EBI-602), ... L-buthionine sulfoximine, nicotine, surfactin from Bacillus subtilis, SilverDYNE®, colloidal silver, EBI-601, and EBI-602), ...
https://www.ars.usda.gov/research/publications/publication/?seqNo115=346124
WHO EMRO | Letter to the Editor | Volume 15, issue 6 | EMHJ volume 15, 2009
In this way, it has been shown that buthionine sulfoximine, an inhibitor of GSH synthesis, exerts an inhibitory effect on L. ...
http://www.emro.who.int/emhj-volume-15-2009/volume-15-issue-6/letter-to-the-editor.html
View topic - R-lipoic acid - Smart Skin Care
2. Maitra I, Serbinova E, Tritschler HJ, Packer L. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced ... Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with ...
http://www.smartskincare.com/forum/viewtopic.php?t=247&start=0&postdays=0&postorder=asc&highlight=
WikiGenes - manoalide - (5R)-5-hydroxy-4-[(2R,6R)-6-hydroxy-5-[(E)...WikiGenes - manoalide - (5R)-5-hydroxy-4-[(2R,6R)-6-hydroxy-5-[(E)...
Simultaneous inhibition of renal phospholipase A(2) and glutathione synthesis by manoalide and DL-buthionine sulfoximine ...
https://www.wikigenes.org/e/chem/e/6437368.html
Modulation of resistance to regional chemotherapy in the extremity melanoma model<...Modulation of resistance to regional chemotherapy in the extremity melanoma model<...
Modulation of GSH was performed with intraperitoneal buthionine sulfoximine (BSO). In parallel, BSO-modulated and nonmodulated ... Modulation of GSH was performed with intraperitoneal buthionine sulfoximine (BSO). In parallel, BSO-modulated and nonmodulated ... Modulation of GSH was performed with intraperitoneal buthionine sulfoximine (BSO). In parallel, BSO-modulated and nonmodulated ... Modulation of GSH was performed with intraperitoneal buthionine sulfoximine (BSO). In parallel, BSO-modulated and nonmodulated ...
https://researchexperts.utmb.edu/en/publications/modulation-of-resistance-to-regional-chemotherapy-in-the-extremit
GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose - Fingerprint - Research...
Buthionine Sulfoximine 55% * Cysteine 55% * Hyperglycemia 35% * Protein Carbonylation 28% * Annexins 25% ...
https://experts.nebraska.edu/en/publications/gsh-protects-against-oxidative-stress-and-toxicity-in-vl-17a-cell/fingerprints/
Alagarraju Muthukumar - Research output - University of Texas Southwestern Medical Center
Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS...Decitabine Induces Delayed Reactive Oxygen Species (ROS) Accumulation in Leukemia Cells and Induces the Expression of ROS...
N-acetyl-l-cysteine (NAC) and dl-buthionine-sulfoximine (BSO) were from Sigma. JC-1 and dihydroethidium (DHE) dyes were from ...
https://aacrjournals.org/clincancerres/article/20/5/1249/78898/Decitabine-Induces-Delayed-Reactive-Oxygen-Species
Liproxstatin-1 (Lip-1) | CAS 950455-15-9 | AbMole BioScience | Liproxstatin-1 Price
DL-Buthionine-(S,R)-sulfoximine DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase ...
http://www.abmole.com/products/liproxstatin-1.html
DeCSDeCS
use BUTHIONINE SULFOXIMINE (NM) to search BUTHIONINE SULFOXIMINE 1980-96. History Note:. 97: was BUTHIONINE SULFOXIMINE (NM) ... Methionine Sulfoximine (1979-1996). Public MeSH Note:. 97; BUTHIONINE SULFOXIMINE was indexed under METHIONINE SULFOXIMINE 1979 ... Buthionine Sulfoximine - Preferred Concept UI. M0028777. Scope note. A synthetic amino acid that depletes glutathione by ... Buthionine sulfoximine Entry term(s):. Sulfoximine, Buthionine. Tree number(s):. D02.886.030.676.620.125. D12.125.166.676. ...
https://decs.bvsalud.org/en/ths/resource/?id=33034
Pesquisa | Prevenção e Controle de CâncerPesquisa | Prevenção e Controle de Câncer
L-buthionine sulfoximine (BSO; an inhibitor of GSH synthesis) slightly enhanced growth inhibition and death in GA-treated lung ... Buthionine sulfoximine (BSO; an inhibitor of GSH synthesis), showing a pro-apoptotic effect on AMA-treated HUVEC, significantly ... L-Buthionine-SR-sulfoximine treatment exerted an additive toxic effect on the CP-treated animals. Interestingly, pretreatment ... We have shown that the protective effect of E2 in the face of l-buthionine (S,R)-sulfoximine -induced oxidative stress is ...
https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=mh:Butionina+Sulfoximina/toxicidade
Understanding cisplatin resistance using cellular models - DORASUnderstanding cisplatin resistance using cellular models - DORAS
... yet treatment with buthionine sulphoximine, an inhibitor of glutathione synthesis, had no effect on resistance, suggesting that ...
https://doras.dcu.ie/2202/
IMSEAR at SEARO: Search
EFFECT OF SUB-TOXIC CONCENTRATIONS OF MEAT METABOLITES ON COLON CANCER CELL GROWTH AND OXIDATIVE STRESS | ScriptieprijsEFFECT OF SUB-TOXIC CONCENTRATIONS OF MEAT METABOLITES ON COLON CANCER CELL GROWTH AND OXIDATIVE STRESS | Scriptieprijs
Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and ...
https://www.scriptiebank.be/scriptie/2017/effect-sub-toxic-concentrations-meat-metabolites-colon-cancer-cell-growth-and
Malaria35Malaria35
... gamma-GCS inhibitor buthionine sulphoximine. In order to investigate further the synthetic pathway of the tripeptide in the ...
http://ehproject.org/Library/Malaria35.html
The Journal of Toxicological Sciences
Male C57BL/6J mice were intraperitoneally pretreated with L-buthionine (S,R)-sulfoximine (BSO) at 700 mg/kg to inhibit GSH ...
https://www.jstage.jst.go.jp/browse/jts/45/8/_contents/-char/en
Bio2Vec
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
https://bio2vec.cbrc.kaust.edu.sa/bio2vec/details/1?iri=http://aber-owl.net/drug/CID005281800
toxBridge
buthionine_sulfoximine. Species. Rat. Experiment type. in_vivo. Please select a dataset.. ID Convert: Rat to Human. Rat. ...
https://toxbridge.id3inst.org/cpw_view/buthionine_sulfoximine/Rat/in_vivo
Treatment with buthionineInhibitorReduction of intracellularGlutathione synthesisEthyl esterAcidEffectSynthesisSpecific inhibitorInhibitsBiosynthesisPretreatmentRATSOxidativeToxicityTumorCellsToleranceHydrogenResistanceCellularSignificantlyDrugProtectionEffects
Treatment with buthionine2
  • These effects were enhanced when cellular reduced glutathione (GSH) levels were lowered by treatment with buthionine sulfoximine (BSO). (unboundmedicine.com)
  • Cisplatin resistance in these cells correlated with increases in the antioxidant glutathione, yet treatment with buthionine sulphoximine, an inhibitor of glutathione synthesis, had no effect on resistance, suggesting that the increase in glutathione was not directly involved in cisplatin resistance. (dcu.ie)
Inhibitor4
  • In this way, it has been shown that buthionine sulfoximine, an inhibitor of GSH synthesis, exerts an inhibitory effect on L. donovani growth [1]. (who.int)
  • DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis . (abmole.com)
  • GSH depletion by buthionine sulfoximine, a potent inhibitor of its synthesis, reflected in a significant decrease of the NSs accumulation, and consequently resulted in a drastic reduction of RV-mediated toxic effects in cancer cells. (unito.it)
  • Effects of a variety of modulating agents on the pattern of resistance, such as the GSH depleter, buthionine sulphoximine, and the GST inhibitor, ethacrynic acid, were determined. (silverchair.com)
Reduction of intracellular2
  • Buthionine sulfoximine (BSO) - mediated reduction of intracellular levels of GSH decreased the ability of the hybrid line WALC to process HEL. (vcu.edu)
  • We observed cadmium-induced dose- as well as time-dependent decline in HLECs viability which was exacerbated significantly upon reduction of intracellular glutathione levels by buthionine sulfoximine (BSO). (umn.edu)
Glutathione synthesis1
  • Oral supplementation of l-buthionine-(S,R)-sulfoximine (BSO) inhibited glutathione synthesis. (cdc.gov)
Ethyl ester1
  • The cell susceptibility to Cd2+ was increased by depletion of glutathione (GSH) with DL-buthionine-[S,R]- sulfoximine, and decreased by N-acetyl-cysteine or glutathione reduced ethyl ester. (edu.au)
Acid2
  • 1. Lockhart B, Jones C, Cuisinier C, Villain N, Peyroulan D, Lestage P. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. (smartskincare.com)
  • 2. Maitra I, Serbinova E, Tritschler HJ, Packer L. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. (smartskincare.com)
Effect1
  • Meer bepaald verhoogt het eten van veel rood en verwerkt vlees het risico met 20% en 30% respectievelijk, terwijl wit vlees zoals kip geen negatief effect blijkt te hebben. (scriptiebank.be)
Synthesis10
  • Buthionine sulfoximine (BSO), a specific inhibitor of GSH synthesis, effectively decreases cellular GSH concentrations both in vitro and in vivo. (usda.gov)
  • Oral supplementation of l-buthionine-(S,R)-sulfoximine (BSO) inhibited glutathione synthesis. (cdc.gov)
  • In this way, it has been shown that buthionine sulfoximine, an inhibitor of GSH synthesis, exerts an inhibitory effect on L. donovani growth [1]. (who.int)
  • After incubation with buthionine sulfoximine, a specific inhibitor of GSH synthesis, prior to oxidant exposure, the same increase in GSSG and GSH in the mucosa was seen. (elsevier.com)
  • Furthermore, the protective effects of 6a were abrogated by the inhibitor of glutathione synthesis, buthionine sulfoximine, confirming the importance of glutathione in the protective activities of 6a . (biomedcentral.com)
  • Moreover, compared to the cysteine treatment, the γ-glutamylcysteine synthetase (γ-GCS) activity, GSH level, mitochondrial membrane potential, ATP level, membrane integrity and progressive motility in boar sperm were decreased by supplementing with an inhibitor of GSH synthesis, buthionine sulfoximine. (animbiosci.org)
  • The glutathione synthesis inhibitor buthionine sulfoximine ablated the protective effect of metformin significantly. (ablkinase.com)
  • Conversely, co-exposure to the GSH synthesis inhibitors, buthionine sulfoximine (BSO) and diethyl maleate (DEM), increased the sensitivity of zebrafish to C60 exposure. (oregonstate.edu)
  • In of L. major infections [ 5 ] and, secondly, this way, it has been shown that buthionine that prostaglandins can inhibit the develop- sulfoximine, an inhibitor of GSH synthesis, ment of Th1 response and enhance the exerts an inhibitory effect on L. donovani development of type 2 helper (Th2) cell growth [ 1 ]. (who.int)
  • In order to modulate GSH levels of K-562 cells , buthionine sulfoximine (BSO) , an inhibitor of GSH synthesis , and GSH ethyl esters were incubated with the cells . (musc.edu)
Specific inhibitor1
  • Furthermore, the effect of GSH on root patterning and drought tolerance was confirmed by growing the atgstu17 in solution containing l-buthionine-(S,R)-sulfoximine, a specific inhibitor of GSH biosynthesis. (nih.gov)
Inhibits1
  • However, opposite data were also reported: overexpression of peroxide-scavenging enzyme, GPx1, enhances production of HIV virions , whereas treatment of such cells with buthionine sulfoximine (BSO) that inhibits glutathione biosynthesis inhibits such increase [158]. (thefreedictionary.com)
Biosynthesis2
  • Cellular thiol concentrations had been changed either by a particular method using buthionine sulfoximine, a particular inhibitor of glutathione biosynthesis or with a nonspecific way, incubating cells in cystine-methionine deficient media. (cox2-inhibitor.com)
  • Both D,L buthionine-S,R-sulfoximine (BSO) and ethacrynic acid (EA), inhibitors of GSH biosynthesis and pi-class GST activity, respectively, could sensitize the ES-2R cells to MRA-CN. (elsevier.com)
Pretreatment2
  • In vivo production of different chloroform metabolites: effect of phenobarbital and buthionine sulfoximine pretreatment. (nih.gov)
  • A comparative study of the toxicity of chemically reactive xenobiotics towards adherent cell cultures: selective attenuation of menadione toxicity by buthionine sulphoximine pretreatment. (childrensmercy.org)
RATS3
  • Carey's dissertation involved preliminary studies of the effects of NACA to slow down cataract growth on rats that had been given L-buthionine-S,R-sulfoximine (BSO), a solution that causes cataracts to form. (mst.edu)
  • Six rats received a proxidant solution of 50 mg/kg doses of both L-buthionine sulfoximine and hydroquinone. (inquiriesjournal.com)
  • Alpha-lipoic journal placenta prevents buthionine sulfoximine-induced cataract formation in newborn rats. (instapicto.top)
Oxidative1
  • zinc l-carnosine protects ccd-18co cells from l-buthionine sulfoximine-induced oxidative stress via the induction of metallothionein and superoxide dismutase 1 expression. (ukm.my)
Toxicity2
  • By using F2-isoprostane quantitation, we examined the effects of selenium deficiency and modulation of glutathione status with 1,3-bis (2-chloroethyl)-1-nitrosourea, phorone or buthionine sulfoximine on diquat-induced toxicity and lipid peroxidation. (nih.gov)
  • 10. Long-term buthionine-sulfoximine-mediated toxicity in cultured hepatoma cell lines. (nih.gov)
Tumor1
  • These tumor types is the base of the fluid shifts, medications, and it is less often en bloc with the prostaglandin analogs, beta-adrenergic blocking agents. (smartfin.org)
Cells4
  • Monoethyl (MEE) and diethyl (DEE) esters of glutathione (GSH) had the capacity to provide some protection of normal and buthionine sulfoximine (BSO) pretreated cells against X-irradiation. (semanticscholar.org)
  • Metabolic modifications to cells had been identified as comes after: glycolysis via a lactate dehydrogenase assay, reducing equivalents by MTT decrease and decreased intracellular thiols by monobromobimane-thiol fluorescence, and glutathione exhaustion using buthionine sulfoximine. (ablkinase.com)
  • The glutathione activity inhibitor buthionine sulfoximine (BSO) considerably reverses this defensive impact, credit reporting the function of decreased glutathione in cisplatin cleansing by metformin-treated cells. (ablkinase.com)
  • Cells only treated with either buthionine sulfoximine or cystine-methionine deficient media did not induce protein S-glutathionylation, even though both conditions decreased 65% of cellular glutathione. (cox2-inhibitor.com)
Tolerance1
  • Buthionine Sulfoximine (BSO) Reduces Chilling Tolerance of a Chilling Tolerant Maize Genotype. (unibe.ch)
Hydrogen1
  • When L-buthionine-[S,R]-sulfoximine (BSO) was administered to increase the intracellular concentration of hydrogen peroxide, the PEs of both cell lines decreased, and when hydrogen peroxide was eliminated by the administration of sodium pyruvate, only the PE of SaOS2FM(H) increased. (elsevier.com)
Resistance2
  • Chemoselection of human prostate cancer cell lines PC3 and DU145 with etoposide resulted in the resistant cell lines PC3-R and DU-R. Resistance against etoposide, doxorubicin and vincristine, and its reversal with leukotriene D4 antagonists MK-571 and zafirlukast, and buthionine sulfoximine (BSO), was assessed using tetrazolium-dye viability assays. (nih.gov)
  • Buthionine sulfoximine reduced resistance to these drugs. (aspetjournals.org)
Cellular1
  • One method for decreasing cellular glutathione is to ingest or inject a synthetic compound, buthionine sulfoximine (BSO). (usda.gov)
Significantly1
  • Buthionine sulfoximine (BSO) at 25µM dramatically depleted GSH and significantly potentiated acrolein-induced cytotoxicity. (uncg.edu)
Drug1
  • A drug called L-Buthionine sulfoximine was deployed, thereby allowing glutamine to be used up. (healthrealsolutions.com)
Protection1
  • When studied using Buthionine Sulphoximine (BSO), a known GSH inhibitor, in the presence of acrolein CDDO-IM treatment no longer induces such remarkable protection. (uncg.edu)
Effects1
  • such vaccination pro- initial preclinical studies against hormone-refractory pc buthionine sulfoximine, have been prostol, 890 mcg, is 98% successful in over 30% in those insignificant effects on sperm capacitation and transport. (smartfin.org)
IJMS | Free Full-Text | Glutathione Plays a Positive Role in the Proliferation of Pinus koraiensis Embryogenic Cells
IJMS | Free Full-Text | Glutathione Plays a Positive Role in the Proliferation of Pinus koraiensis Embryogenic Cells (mdpi.com)
Ácido alfa lipoico: MedlinePlus suplementos
Ácido alfa lipoico: MedlinePlus suplementos (medlineplus.gov)
PDF) Glutathione Metabolism and Its Implications for Health
PDF) Glutathione Metabolism and Its Implications for Health (researchgate.net)
Find Research outputs - Discovery - the University of Dundee Research Portal
Find Research outputs - Discovery - the University of Dundee Research Portal (discovery.dundee.ac.uk)
WHO EMRO | Letter to the Editor | Volume 15, issue 6 | EMHJ volume 15, 2009
WHO EMRO | Letter to the Editor | Volume 15, issue 6 | EMHJ volume 15, 2009 (emro.who.int)
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems (hindawi.com)
WikiGenes - manoalide - (5R)-5-hydroxy-4-[(2R,6R)-6-hydroxy-5-[(E)...
WikiGenes - manoalide - (5R)-5-hydroxy-4-[(2R,6R)-6-hydroxy-5-[(E)... (wikigenes.org)
Modulation of resistance to regional chemotherapy in the extremity melanoma model<...
Modulation of resistance to regional chemotherapy in the extremity melanoma model<... (researchexperts.utmb.edu)
GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose - Fingerprint - Research...
GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose - Fingerprint - Research... (experts.nebraska.edu)
Alagarraju Muthukumar - Research output - University of Texas Southwestern Medical Center
Alagarraju Muthukumar - Research output - University of Texas Southwestern Medical Center (utsouthwestern.pure.elsevier.com)
Liproxstatin-1 (Lip-1) | CAS 950455-15-9 | AbMole BioScience | Liproxstatin-1 Price
Liproxstatin-1 (Lip-1) | CAS 950455-15-9 | AbMole BioScience | Liproxstatin-1 Price (abmole.com)
Bio2Vec
Bio2Vec (bio2vec.cbrc.kaust.edu.sa)
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress...
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress... (experts.arizona.edu)
尾崎 倫孝(オザキ ミチタカ)(保健科学研究院 保健科学部門 基盤看護学分野) | 北海道大学の研究者（北海道大学研究者総覧）
尾崎 倫孝(オザキ ミチタカ)(保健科学研究院 保健科学部門 基盤看護学分野) | 北海道大学の研究者（北海道大学研究者総覧） (researchers.general.hokudai.ac.jp)
Stand UP 2 Cancer
Stand UP 2 Cancer (youthfulandageless.com)
Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells. | Semantic Scholar
Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells. | Semantic Scholar (semanticscholar.org)
Landmark studies in vitamin c
Landmark studies in vitamin c (cyclingforums.com)
Project Publications: University of Cincinnati: Environmental Fate of Azo Dyes and Related Products (Superfund Research Program)
Project Publications: University of Cincinnati: Environmental Fate of Azo Dyes and Related Products (Superfund Research Program) (tools.niehs.nih.gov)
Program Publications: University of Cincinnati: Health Effects and Biodegradation of Complex Mixtures (Superfund Research...
Program Publications: University of Cincinnati: Health Effects and Biodegradation of Complex Mixtures (Superfund Research... (tools.niehs.nih.gov)
MeSH Browser
MeSH Browser (meshb.nlm.nih.gov)
Eugenol (Clove Oil) - LiverTox - NCBI Bookshelf
Eugenol (Clove Oil) - LiverTox - NCBI Bookshelf (ncbi.nlm.nih.gov)