Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.Library Services: Services offered to the library user. They include reference and circulation.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Libraries, MedicalEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Medication Adherence: Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Kidney Function Tests: Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.Marijuana Abuse: The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.Marijuana Smoking: Inhaling and exhaling the smoke from CANNABIS.Motivation: Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.Psychological Techniques: Methods used in the diagnosis and treatment of behavioral, personality, and mental disorders.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Names: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Blood Pressure Determination: Techniques for measuring blood pressure.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.Anxiety Disorders: Persistent and disabling ANXIETY.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Pharmacies: Facilities for the preparation and dispensing of drugs.Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Visual Prosthesis: Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.Lysosomal Storage Diseases, Nervous System: A group of enzymatic disorders affecting the nervous system and to a variable degree the skeletal system, lymphoreticular system, and other organs. The conditions are marked by an abnormal accumulation of catabolic material within lysosomes.Forensic Medicine: The application of medical knowledge to questions of law.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Citalopram: A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.Bupropion: A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.Antidepressive Agents, Second-Generation: A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.New England: The geographic area of New England in general and when the specific state or states are not indicated. States usually included in this region are Maine, New Hampshire, Vermont, Massachusetts, Connecticut, and Rhode Island.

Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. (1/150)

The present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1A (serotonin) (5-HT1A) receptor agonist, alnespirone [S-20499, (S)-N-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-HT1A agonist 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT), the partial 5-HT1A agonists ipsapirone and buspirone, and the mixed 5-HT1A/1B agonist eltoprazine. All five agonists exerted effective dose-dependent decreases of offensive aggressive behavior in resident rats; 8-OH-DPAT was the most potent (ID50 = 0.074 mg/kg), followed by eltoprazine (0.24), buspirone (0.72), ipsapirone (1.08), and alnespirone (1.24). However, in terms of selectivity of the antiaggressive effects as determined by the absence of decrements in social interest and general motor activity, alnespirone appeared to be superior. In the defensive aggression test, neither alnespirone nor any of the other four agonists changed defensive behaviors in the intruder rats. The involvement of 5-HT1A receptors in the antiaggressive actions of these drugs was confirmed by showing that the selective 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride), which was inactive alone, fully prevented the antiaggressive effects of alnespirone, 8-OH-DPAT, and buspirone and partly reversed those of ipsapirone and eltoprazine. The data clearly indicate that alnespirone effectively suppresses offensive aggression with an advantageous profile of action compared with other full or partial 5-HT1A agonists. These selective antiaggressive actions of alnespirone are mediated by stimulating 5-HT1A receptors, presumably the somatodendritic autoreceptors at the raphe nuclei. Furthermore, the data provide evidence for a major involvement of these 5-HT1A receptors in the modulation of aggressive behavior by 8-OH-DPAT, ipsapirone, buspirone, and eltoprazine.  (+info)

A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses. (2/150)

The involvement of adenosine on the development of time-dependent reversal of long-term potentiation (LTP) by low-frequency stimulation (LFS) was investigated at Schaffer collateral-CA1 synapses of rat hippocampal slices. A train of LFS (2 Hz, 10 min, 1200 pulses) had no long-term effects on synaptic transmission but produced lasting depression of previously potentiated responses. This reversal of LTP (depotentiation) was observed when the stimulus was delivered +info)

Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists. (3/150)

The 5-HT1A receptor is implicated in depression and anxiety. This receptor couples to G(i) proteins to inhibit adenylyl cyclase (AC) activity but can stimulate AC in tissues (e.g. hippocampus) that express ACII. The role of ACII in receptor-mediated stimulation of cAMP formation was examined in HEK-293 cells transfected with the 5-HT1A receptor, which mediated inhibition of basal and G(s)-induced cAMP formation in the absence of ACII. In cells cotransfected with 5-HT1A receptor and ACII plasmids, 5-HT1A agonists induced a 1. 5-fold increase in cAMP level. Cotransfection of 5-HT1A receptor, ACII, and Galpha(i2), but not Galpha(i1), Galpha(i3), or Galpha(o), resulted in an agonist-independent 6-fold increase in the basal cAMP level, suggesting that G(i2) preferentially coupled the receptor to ACII. The 5-HT1B receptor also constitutively activated ACII. Constitutive activity of the 5-HT1A receptor was blocked by pertussis toxin and the Gbetagamma antagonist, betaCT, suggesting an important role for Gbetagamma-mediated activation of ACII. The Thr-149 --> Ala mutation in the second intracellular domain of the 5-HT1A receptor disrupted Gbetagamma-selective activation of ACII. Spontaneous 5-HT1A receptor activity was partially attenuated by 5-HT1A receptor partial agonists with anxiolytic activity (e.g. buspirone and flesinoxan) but was not altered by full agonists or antagonists. Thus, anxiolytic activity may involve inhibition of spontaneous 5-HT1A receptor activity.  (+info)

Stability-indicating high-performance liquid chromatographic assay of buspirone HCl. (4/150)

The United States Pharmacopoeia high-performance liquid chromatographic (HPLC) assay method of buspirone is not able to discriminate buspirone from its degradation products. The purpose of this work is to develop a sensitive, selective, and validated stability-indicating HPLC assay for the analysis of a buspirone hydrochloride in a bulk drug. Buspirone HCI and its potential impurities and degradation products are analyzed on an Ultrasphere C18 column heated to 40 degrees C using a gradient program that contains monobasic potassium phosphate buffer solution (pH 6.9) and acetonitrile-methanol mixture (13:17) of 35% for 5 minutes, then increased to 54% in 5.5 minutes. The samples are monitored using a photo-diode array detector and integrated at 244 and 210 nm. The stress testing of buspirone HCI shows that buspirone acid hydrochloride is the major degradation product. The developed method shows a separation of buspirone degradation product and its potential impurities in one run. The stability of buspirone HCI is studied under accelerated conditions in order to provide a rapid indication of differences that might result from a change in the manufacturing process or source of the sample. The forced degradation conditions include the effect of heat, moisture, light, acid-base hydrolysis, sonication, and oxidation. The compatibility of buspirone HCI with some pharmaceutical excipients is studied under stress conditions. The linear range of buspirone HCI is between 5 and 200 ng/microL with a limit of quantitation of 2.5 ng/microL. The intraassay percentage deviation is not more than 0.38%, and the day-to-day variation was not more than 0.80%. The selectivity, repeatability, linearity, range, accuracy, sample solution stability, ruggedness, and robustness show acceptable values.  (+info)

Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. (5/150)

The purpose of our study was to test the hypothesis that 5-hydroxytryptamine (5-HT)(1A) receptor agonists counteract morphine-induced respiratory depression. Studies were conducted in anesthetized rats, and respiratory activity was monitored with diaphragm electromyography. Morphine was administered i.v. in doses that produce apnea. Once apnea was established, i.v. administration of the 5-HT(1A) receptor agonist drug 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) at 10 or 100 microgram/kg restored normal breathing in each animal (n = 24). This antagonistic effect of 8-OH-DPAT on morphine-induced respiratory depression was observed in both spontaneously breathing and artificially ventilated animals. Results obtained with 8-OH-DPAT were mimicked by buspirone (50 microgram/kg i.v.), another 5-HT(1A) receptor agonist drug. Pretreatment with 4-(2'-methoxyphenyl)-1-[2'[N-(2'-pyridinyl]-p-iodo-benzamido]ethyl]pi perazine, an antagonist of 5-HT(1A) receptors, prevented 8-OH-DPAT from counteracting morphine-induced apnea. These results indicate that activation of central nervous system 5-HT(1A) receptors is an effective way of reversing morphine-induced respiratory depression. Most important, this is the third model of disturbed respiratory function in which drugs that stimulate 5-HT(1A) receptors have been shown to restore breathing to near-normal levels.  (+info)

Contribution of development to buspirone effects on REM sleep: a preliminary report. (6/150)

In order to assess whether development influences the regulation of rapid eye movement (REM) sleep by serotonergic (5-HT) systems, the REM sleep responses to the partial 5-HT(1A) agonist, buspirone, were assessed in 14 normal adolescent and adult volunteers. Subjects were studied on three separate sessions for three consecutive nights. On the second night of each session, subjects received placebo or one of two doses of buspirone (0.14 mg/kg and 0.28 mg/kg, orally). Night 3 was considered the "recovery" night. In adolescents, both doses of buspirone significantly delayed REM latency. In contrast, low-dose buspirone had no effect on REM latency in the adults, and there was only a tendency for prolongation of REM latency with the higher dose. Other measures of REM sleep on nights 2 and 3 were comparable between the two groups. These preliminary results suggest that post-synaptic 5-HT(1A) acceptor-coupled REM sleep responses, particularly REM latency, may be relatively greater in youngsters than in adults, possibly due to reduced presynaptic input. The findings are discussed in relation to the age-dependent expression of REM sleep changes associated with depression.  (+info)

Liquid chromatographic method for the analysis of buspirone HCl and its potential impurities. (7/150)

An accurate, reproducible, and sensitive method for the determination of buspirone HCl and its potential impurities is developed and validated. The validated liquid chromaography method is conducted to meet the Food and Drug Administration/ International Conference on Harmonization requirements for the analysis of buspirone HCI in the presence of its impurities. Five buspirone HCI potential impurities, including 1-(2-pyrimidinyl)-piperazine (I), propargyl chloride (II), 3,3'-tetramethylene glutarimide (III), propargyl glutarimide (IV), and the Mannich base-condensate of I-IV fumarate (V), are separated using a microBondapack C18 column by gradient elution with a flow rate 2.0 mL/min. The initial mobile phase composition is 90:10 (v/v) 10mM KH2PO4 (pH 6.1)-acetonitrile. After a 1-min initial hold, a linear gradient is performed in 26 min to 35:65 (v/v) 10mM KH2PO4 (pH 6.1)-acetonitrile. The samples are detected at 210 and 240 nm using a photo-diode array detector. The linear range of detection for buspirone HCI was between 1.25 ng/microL and 500 ng/microL, with a limit of quantification of 1.25 ng/microL. The linearity, range, peak purity, selectivity, system performance parameters, precision, accuracy, and robustness for all of the impurities were also shown to have acceptable values.  (+info)

Behavioral effects of plant-derived essential oils in the geller type conflict test in mice. (8/150)

The present study was conducted to further explore plant-derived essential oils that possess an anticonflict effect using the Geller type conflict test in ICR mice. The benzodiazepine anxiolytic diazepam increased the response (lever pressing) rate during the alarm period (i.e., an anticonflict effect), but the 5-HT1A partial agonist buspirone did not. Oils of juniper, cypress, geranium and jasmine did not produce any effect in this test. Frankincense oil decreased the response rate during the safe period at 1600 mg/kg, but did not exhibit any effect on the response rate during the alarm period. In contrast, lavender oil increased the response rate during the alarm period in a dose-dependent manner in the same manner as diazepam. These results indicate that not only rose oil but also lavender oil possess an anticonflict effect in mice.  (+info)

*Buspirone

... is the INN, BAN, DCF, and DCIT of buspirone, while buspirone hydrochloride is its USAN, BANM, and JAN. Buspirone is ... In addition, buspirone does not produce euphoria, and is not a drug of abuse. Buspirone appears to be relatively benign in ... Likewise in Australia, buspirone is licensed for the treatment of anxiety disorders. In the United Kingdom, buspirone is ... There is evidence that buspirone may be used to treat Cerebellar ataxia. There is some evidence that buspirone on its own may ...

*Buspirone/testosterone

... (tentative brand name Lybridos) is a combination of buspirone, a 5-HT1A receptor partial agonist, α2- ... Both buspirone and testosterone have individually been found to be effective in the treatment of female sexual dysfunction in ... Buspirone/testosterone - AdisInsight Female sexual disorders: Treatment options in the pipeline. ... List of investigational sexual dysfunction drugs Bremelanotide Flibanserin Intrinsa Loane C, Politis M (2012). "Buspirone: what ...

*List of side effects of buspirone

Side effects of buspirone by incidence include: Very common (>10% incidence) Dizziness/lightheadedness Headache Somnolence ( ...

*List of dopaminergic drugs

Buspirone • Butaclamol • Ecopipam • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) • Eticlopride • Fananserin • L- ...

*Brazilian Controlled Drugs and Substances Act

BUSPIRONE 16. BUTAPERAZINE 17. BUTRIPTILINE 18. CAPTODIAMINE 19. CARBAMAZEPINE 20. CAROXAZONE 21. CETAMINE 22. CYCLARBAMATE 23 ...

*Nerisopam

Comparison with chlordiazepoxide and buspirone. Acta Physiologica Hungarica. 1992;79(2):153-61. Palkovits M, Baffi JS, ...

*Girisopam

Comparison with chlordiazepoxide and buspirone. Acta Physiologica Hungarica. 1992;79(2):153-61. Horváth EJ, Salamon C, Bakonyi ...

*Azapirone

Buspirone is being investigated for this purpose as well. Gepirone was abandoned after FDA rejection. Buspirone was originally ... Sumiyoshi T, Park S, Jayathilake K, Roy A, Ertugrul A, Meltzer HY (September 2007). "Effect of buspirone, a serotonin1A partial ... June 1990). "Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment ... Bouwer C, Stein DJ (April 1997). "Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in ...

*Grapefruit-drug interactions

Grapefruit juice increased peak and AUC plasma concentrations of buspirone 4.3- and 9.2-fold, respectively, in a randomized, 2- ... "Grapefruit juice substantially increases plasma concentrations of buspirone". Clinical Pharmacology and Therapeutics. 64 (6): ... Metabolized into norbuprenorphine by CYP3A4 Buspirone (Buspar): ...

*Cannabis use disorder

Buspirone shows promise as a treatment for dependence; trials show it reducing cravings, irritability and depression. ...

*Anxiolytic

Currently approved azapirones include buspirone (Buspar) and tandospirone (Sediel).[citation needed] Pregabalin's anxiolytic ...

*Generalized anxiety disorder

5-HT1A receptor partial agonists, such as buspirone and tandospirone. Serotonin-norepinephrine reuptake inhibitors (SNRIs), ...

*Cerebellar ataxia

Additionally, mild to moderate cerebellar ataxia may be treatable with buspirone. It is thought that the buspirone increases ... Trouillas, Paul; Xie, Jing; Adeleine, Patrice (1996). "Treatment of cerebellar ataxia with buspirone: a double-blind study". ...

*Sohrab Rohani

J. Pharm., 338, 55-63 (2007). Sheikhzadeh M; Rohani S; Jutan A; Manifar T Quantitative and molecular analysis of buspirone ... Solubility Analysis of Buspirone Hydrochloride Polymorphs: Measurements and Prediction, Int. ... Kinetics Estimation and Polymorphic Transformation Modeling of Buspirone Hydrochloride, J. Cryst. Process Technol., 2(2), 31-43 ...

*Agonist

E.g. buspirone is a selective agonist for serotonin 5-HT1A. Partial agonists (such as buspirone, aripiprazole, buprenorphine, ...

*Flesinoxan

8-OH-DPAT Befiradol Buspirone Eptapirone Schoeffter P, Hoyer D (1988). "Centrally acting hypotensive agents with affinity for 5 ...

*Benzodiazepine withdrawal syndrome

Buspirone augmentation was not found to increase the discontinuation success rate. Caffeine may worsen withdrawal symptoms ... Prospective Comparison of Clorazepate and Buspirone". Archives of General Psychiatry. 45 (5): 444-50. doi:10.1001/archpsyc. ...

*Post viral cerebellar ataxia

However, the following drugs may be prescribed: clonazepam, amantadine, gabapentin, or buspirone. Occupational or physical ...

*Umespirone

I. Antipsychotic and anxiolytic activity in comparison with chlorpromazine, clozapine, diazepam and buspirone". ...

*5-HT1A receptor

... agonists like buspirone and flesinoxan show efficacy in relieving anxiety and depression, and buspirone and ... Cohn JB, Rickels K (1989). "A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with ... Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (March 1995). "Buspirone, but not sumatriptan, induces miosis in humans: ... αMT Aripiprazole Asenapine Bacoside Bay R 1531 Befiradol Binospirone Brexpiprazole Bufotenin Buspirone Cannabidiol Cariprazine ...

*Pyrimidinylpiperazine

... and buspirone on locus coeruleus neuronal activity". Eur. J. Pharmacol. 459 (1): 17-26. doi:10.1016/s0014-2999(02)02814-5. PMID ... A comparison to buspirone and its metabolite, 1-pyrimidinylpiperazine". European Neuropsychopharmacology. 7: S149-S150. doi: ... "Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors". Int ... Buspirone - anxiolytic Dasatinib - anticancer agent Eptapirone - anxiolytic Gepirone - anxiolytic Ipsapirone - anxiolytic ...

*Atypical depression

Antidepressant response can often be enhanced with supplemental medications, such as buspirone, bupropion, or aripiprazole. ...

*Eptapirone

In addition, the efficacy of eptapirone in this assay was more evident than that of buspirone, ipsapirone, and flesinoxan. ... November 2005). "The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans". Journal of ... In this assay, unlike the other drugs screened, buspirone actually increased the immobility time with a single administration, ... In the Porsolt forced swimming test, eptapirone was found to suppress immobility more robustly than buspirone, ipsapirone, ...

*Flibanserin

June 2002). "Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain". Int. J. ... 8-OH-DPAT and buspirone on serotonin synthesis in rat brain". Eur Neuropsychopharmacol. 10 (1): 63-7. doi:10.1016/S0924-977X(99 ...

*Dysthymia

Such treatment augmentations can include lithium pharmacology, thyroid hormone augmentation, amisulpride, buspirone, bupropion ...
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence. This study will evaluate the efficacy of buspirone for reducing marijuana use in marijuana-dependent adults. A contingency management (CM) intervention and motivational enhancement therapy (MET) will be incorporated to encourage study engagement and retention. It is hypothesized that buspirone combined with MET and CM will reduce the percent of marijuana-positive urine drug screen results in marijuana-dependent individuals as compared to a placebo treatment combined with MET and CM ...
Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms. Buspirone is not an anti-psychotic medication and...
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Buspirone Definition Buspirone is an anti-anxiety (anxiolytic) drug sold in the United States [1] under the brand name of BuSpar. It is also available under its generic name.
... is an anxiolytic medicine, used to reduce fear, tension and anxiety associated with anxiety disorders. Buspirone affects the chemicals in your brain that may have become unbalanced and ar...
Sustained-Release Bupropion or Buspirone May Augment Citalopram Response March 23, 2006 by Laurie Barclay, MD, Medscape Patients with depression not responding adequately to citalopram may respond to the addition of either bupropion or buspirone, with the former having certain advantages, according to the results of a randomized study reported in the March 23 issue of The New England Journal of Medicine. Although clinicians frequently add a second medication to an initial, ineffective
PURPOSE OF PROJECT: To study the effect expressed by persons with TBI through assessment of buspirone effectiveness for post-traumatic irritability and aggression and development of an irritability/aggression impact measure.. SUMMARY OF PROJECT: It is anticipated that 74 subjects with 74 corresponding subject observers will be recruited for the treatment study. Subjects will be recruited from community and self-referrals.. Interested potential participants will be scheduled for an in-person screening visit. Subjects who consent and qualify will be randomized in a 1:1 ratio, buspirone or placebo. Stratification to randomization group will occur based on the presence of major or minor depression (defined by PHQ-9 total score ,5). Randomized subjects will receive active treatment or placebo. There will be 4 clinic visits. Visits will occur at baseline, for consenting and screening, day 35, day 63 and day 91. At all 4 clinic visits, both the subject and the observer will be given questionnaires ...
Results CT evaluations revealed that 12 patients had supra-, and 21 had infra-aortic esophagus dilatation (mean diameters 12.4±5.3 and 22.5±11.0 mm, respectively, normal ,10 mm). Baseline esophageal hypomotility was observed in 68% and hypotensive LES in 75% of patients. Most intense symptoms were heartburn and regurgitation followed by dysphagia and retrosternical pain (mean scores 39±30, 37±24, 23±27 and 10±24 respectively). After 4 weeks of buspirone, LES resting pressure increased from 6.8±2.7 to 10.6±4.3 mmHg (p=0.007). Percent improvement was less prominent in patients with supra-aortic esophagus dilatation (29.2±19.8% versus 83.9±38.1% in patients without dilatation, p=0.037), whereas bivariate regression analysis revealed a negative correlation between individual increases of resting LES pressure and supra-aortic diameter (r=-0,613 p=0.058), indicating that buspirone exerts a greater effect in patients with less affected esophagus. No significant changes were noted on other ...
Buspirone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Buspirone is available on the Drugs.com website.
Neogens Buspirone ELISA (Enzyme-Linked ImmunoSorbent Assay) test kit is a qualitative one-step kit designed for use as a screening device for the detection of Buspirone and/or their metabolites. The kit was designed for screening purposes and is intended for forensic use only.. ...
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It is approved for the treatment of generalized anxiety disorder (GAD) Buspirone is a prescription drug. Iv been taking buspar for a month now, 10mg a day one in the morning and one at night. 1 Order Zyprexa Canada mg, 13. About buspirone. However, buspirone usually is not used for anxiety or tension caused by the stress of everyday life. Iv been taking buspar for a month now, 10mg a day one in the morning and Benadryl Buy Bulk one at night. Buspar also tends not to cause significant sedation Taking MAO inhibitors with Buspar 10mg may cause a serious (possibly fatal) drug interaction. Buspirone is an anti-anxiety medicine that affects chemicals Provera Birth Control Pill in your brain that may become unbalanced and cause anxiety. Is it safe to take 10 mg of Buspar twice a day after I stopped taking it for about one month? Buspirone is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. It may also help you to feel less jittery and irritable, and may control symptoms ...
F 11440 is a potent, selective and efficacious 5-HT1A receptor agonist. Its affinity for 5-HT1A binding sites was higher than that of the partial agonist, buspirone, which is clinically available as an anxiolytic, and somewhat lower than that of the reportedly higher-efficacy 5-HT1A agonist, flesinoxan, which is in phase III of clinical development as an anxiolytic/antidepressant. In vivo, F 11440 was ∼4 to 10 times more potent than flesinoxan, and nearly 100 times more potent than buspirone, in exerting 5-HT1A agonist activity after oral administration. F 11440 did not have detectable antidopaminergic or antihistaminergic activity (unlike buspirone and flesinoxan, respectively) and had a 70-fold separation between its 5-HT1A agonist and alpha-1 antagonist properties in vivo, unlike flesinoxan, which showed a ,3-fold separation. F 11440 had intrinsic activity at human 5-HT1A receptors higher than that of buspirone, ipsapirone, and flesinoxan. Thus, F 11440 appears to be a more potent, a more ...
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Behavioral effects of 5-{3-[((2,I,S,/I,)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy}-1, 3-benzodioxole HCl (MKC-242), a novel 5-HT,SUB,1A,/SUB,-receptor agonist, were evaluated using animal models of anxiety and obsessive compulsive disorder and compared against reference compounds. MKC-242 suppressed foot shock-induced fighting behavior without loss of motor coordination in mice as the reference compounds did. The ED,SUB,50,/SUB, values of MKC-242, buspirone, tandospirone and diazepam were 1.7, 42, 80 and 2.0 mg/kg, p.o., respectively. The duration of the suppression of fighting by MKC-242 was longer than those of buspirone and tandospirone and comparable to that of diazepam. Similar results were also obtained with the water-lick conflict test in rats. The plasma concentration of MKC-242 in rats was much higher than the reported value of buspirone during 0.25 - 6 hr after oral administration. In addition, MKC-242 reduced marble burying behavior without reduction of motor activity. ...
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The use of benzodiazepines in patients with a history of substance abuse is a relative contraindication because of the increased risk of addiction and abuse. In addition to the risk of dependence and withdrawal syndrome, other ADRs include respiratory depression and overdose. Due to the risk of respiratory depression, these agents should be avoided whenever possible in patients with respiratory diseases. Small doses of benzodiazepines may be utilized long term in patients with refractory anxiety who have failed multiple therapies.7. Buspirone: Buspirones mechanism of action is not fully understood, but it is believed to suppress serotonergic activity while enhancing noradrenergic and dopaminergic actions.14 It has a high affinity for 5-HT1A receptors and a moderate affinity for dopamine D2 receptors but does not affect the benzodiazepine-GABA receptors. The recommended initial dose is 7.5 mg twice daily with a maximum dose of 60 mg/day. Buspirone is not known to cause drug dependence.7 ...
Its important to note that Buspar medication addresses symptoms of anxiety and should not be used as an alternative drug to mental illnesses. Mental illnesses demand anti-psychotic drugs.. Buspar medication cannot be prescribed to a patient who has taken MAO inhibitors such as linezolid and tranylcypromine in the recent past up to a fortnight.. Patients with allergic reactions to Burispone should also avoid Buspar medication.. Buspar medication CAN ONLY be prescribed and used by adults who have attained the legal age of 18 years in Canada.. Side effects of Buspar medication may be aggravated by the intake of other drugs that bring similar side effects.. Avoid intake of alcohol with Buspar medication. Do not take Buspar and drive or operate machinery.. When switching to Buspar from other medication, start with small doses and increase gradually.. Buspar medication at a pharmacy and home should be stored at room temperature away from excessive moisture and heat and light. Store safely away fro ...
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Drowsiness/reduced alertness: This medication may impair the mental or physical abilities required for certain tasks, such as driving a car or operating machinery. Do not drive or operate dangerous machinery while using this medication until you have determined how this medication affects you.. Kidney function: The kidneys are involved in removing buspirone from the body. People with reduced kidney function may experience increased side effects of buspirone as a result of it not being removed as quickly as expected.. If you have kidney disease or reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the ...
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment ...
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Serotoninergic pathways projecting from the median and dorsal raphe nuclei to the hippocampus, amygdala and other limbic structures play a major role in the control of mood (Coplan et al., 1995) and there is evidence that their overactivity contributes to anxious states (Barrett and Gleeson, 1991; Coplan et al., 1995; Lesch, 1991; Millan and Brocco, 1993). Correspondingly, a component of the anxiolytic action of BZPs can be attributed to a reinforcement of the inhibitory tone exerted by GABAergic neurons on these serotoninergic pathways (Lista et al., 1990; Pan and Williams, 1989). In analogy, the inhibition of ascending serotoninergic transmission via activation of inhibitory 5-HT1A autoreceptors localized on cell bodies by buspirone, for example, appears to underlie anxiolytic effects in both operant, conflict-based paradigms, such as the pigeon and rat conflict tests (Barrett and Gleeson, 1991; Cervo and Samanin, 1995a, b; Schefkeet al., 1989; Schreiber et al., 1995a), as well as in ...
This eMedTV page deals with the use of benzodiazepines and buspirone as possible anxiety treatments. Topics discussed include pros and cons, possible side effects, and when long-term use is indicated.
Diagnosed with mid level depression and panic/anxiety attacks. I have been on buspirone and it does not seem to work. Doc wants me to stay on that and then take 1 Lexapro per day. Also a sleep aid...
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When you see shaded dots in the green "Use as Directed" category, it means that although the patient has variation in one or more genes, it is unlikely to impact their response to that particular medication. This could mean that while an enzyme is involved in the metabolism of the medication, its role is not clinically significant enough to warrant a change in dosing. For example, buspirone (Buspar®) is metabolized by CYP3A4 and CYP2D6.1-3 Since CYP2D6 plays a very minor role in Buspar® metabolism, variation in this gene will not likely change the way Buspar® is metabolized, and therefore Buspar® will remain in the green category even when CYP2D6 has a shaded dot.. Another reason a medication in the green category could have shaded dots is that the enzymes involved have opposite phenotypes and therefore compensate for one another. For example, vilazodone (Viibryd®) is metabolized by three different enzymes: CYP2C19, CYP3A4, and CYP2D6.4 In the example below, the patient is ultrarapid for ...
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Laboratory abnormalities in ME/CFS include abnormal SIgA; weakly positive IgG3 (linked to gastrointestinal tract disorders); positive IgM; increased T4:T8 ratio (which always corresponds with disease severity); very low numbers of NK cells, with decreased cytolytic activity; low levels of circulating immune complexes (two-thirds of ME patients have insoluble circulating immune complexes); autoantibodies (especially antinuclear and smooth muscle); a particular HLA antigen expression; PCR evidence of abnormalities in muscle; a positive water loading test with erratic arginine-vasopressin release; a significant prolactin release in response to a single buspirone challenge; positive SPECT scans (which show reduced blood flow through the brain stem in a particular pattern not found in any other illness or disease process apart from ME/CFS - QJMed 1995:88:767-773); abnormal fMRI scans; abnormal EEG (80% of ME patients show prolonged jitter); a positive VP1 test; positive mast cells; low pancreatic ...
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While some worry and tension is normal, an anxiety disorder includes extreme feelings of tension, irritability, worry, frustration, turmoil, and hopelessness. Insomnia, restless sleep, grinding of teeth, jaw pain, an inability to sit still and difficulty coping are common. Anxiety may give rise to panic attacks, which can be so severe that they can be mistaken for a heart attack. Several medical treatments are available including anti-anxiety drugs in the benzodiazepine family, the unique drug BuSpar (buspirone), and antidepressants. Massage, biofeedback and other relaxation techniques can be helpful. Natural options include GABA, St. Johns Wort and L-Theanine.
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High-potency benzodiazepines combat anxiety and have few side effects other than drowsiness. Because people can get used to them and may need higher and higher doses to get the same effect, benzodiazepines are generally prescribed for short periods of time, especially for people who have abused drugs or alcohol and who become dependent on medication easily. One exception to this rule is people with panic disorder, who can take benzodiazepines for up to a year without harm.. Clonazepam (Klonopin®) is used for social phobia and GAD, lorazepam (Ativan®) is helpful for panic disorder, and alprazolam (Xanax®) is useful for both panic disorder and GAD.. Some people experience withdrawal symptoms if they stop taking benzodiazepines abruptly instead of tapering off, and anxiety can return once the medication is stopped. These potential problems have led some physicians to shy away from using these drugs or to use them in inadequate doses.. Buspirone (Buspar®), an azapirone, is a newer anti-anxiety ...
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Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs. The degree of symptoms can range from mild to severe. Symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea. Body temperature can increase to greater than 41.1 °C (106.0 °F). Complications may include seizures and extensive muscle breakdown. Serotonin syndrome is typically caused by the use of two or more serotonergic medications or drugs. This may include selective serotonin reuptake inhibitor (SSRI), serotonin norepinephrine reuptake inhibitor (SNRI), monoamine oxidase inhibitor (MAOI), tricyclic antidepressants (TCAs), amphetamines, pethidine (meperidine), tramadol, dextromethorphan, buspirone, L-tryptophan, 5-HTP, St. Johns wort, triptans, ecstasy (MDMA), metoclopramide, ondansetron, or cocaine. It occurs in about 15% of SSRI overdoses. It is a predictable consequence of excess serotonin on the central ...

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Buspirone - Substance Information - ECHABuspirone - Substance Information - ECHA

Buspirone. Regulatory process names 1 CAS names 1 IUPAC names 3 Other identifiers 1 ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.048.232

DailyMed - BUSPIRONE HYDROCHLORIDE- buspirone hydrochloride tabletDailyMed - BUSPIRONE HYDROCHLORIDE- buspirone hydrochloride tablet

buspirone hydrochloride 15 MG Oral Tablet. SCD. 3. 866018. buspirone hydrochloride 15 MG (as buspirone 13.7 MG) Oral Tablet. SY ... BUSPIRONE HYDROCHLORIDE- buspirone hydrochloride tablet To receive this label RSS feed. Copy the URL below and paste it into ... Each buspirone hydrochloride tablet intended for oral administration contains 5 mg or 10 mg or 15 mg or 30 mg buspirone ... Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect ...
more infohttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1109dd63-6492-49b1-a383-3ab3a80cd6c7

buspirone - WellSpan Health Librarybuspirone - WellSpan Health Library

Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other ... Buspirone is not an anti-psychotic medication and... ... Buspirone is an anti-anxiety medicine that affects chemicals in ... What is the most important information I should know about buspirone?. Do not use buspirone if you have taken an MAO inhibitor ... What is buspirone?. Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people ...
more infohttps://www.wellspan.org/health-library/Document.aspx?id=d00182a1

buspirone | Drugs-Forumbuspirone | Drugs-Forum

Drug info - Buspirone and Recreational Drugs. So my doctor has prescibed me a small dose of buspirone HCL for anxiety/ ... Experiences - Crappy Buspirone experience. Seeing as how buspirone is legal, Im ditching the swim stuff and just straight up ... Buspirone. Buspirone (BuSpar) is an anti-anxiety (anxiolytic agent) that has shown to be as effective as benzodiazepines in ... I started taking buspirone a couple of months ago. Are there known issues of using crack while prescribed buspirone. I also ...
more infohttps://drugs-forum.com/tags/buspirone/

Buspirone facts, information, pictures | Encyclopedia.com articles about BuspironeBuspirone facts, information, pictures | Encyclopedia.com articles about Buspirone

Make research projects and school reports about Buspirone easy with credible articles from our FREE, online encyclopedia and ... Buspirone. Definition. Buspirone is an anti-anxiety (anxiolytic) drug sold in the United States under the brand name of BuSpar ... Buspirone is available in 5-, 10-, 15-, and 30-mg tablets.. Recommended dosage. The usual starting dose of buspirone is 10 to ... When patients are receiving certain other drugs (see below) in addition to buspirone, starting doses of buspirone may need to ...
more infohttps://www.encyclopedia.com/medicine/drugs/pharmacology/buspirone

Buspirone (BuSpar) - Side Effects, Dosage, Interactions - DrugsBuspirone (BuSpar) - Side Effects, Dosage, Interactions - Drugs

Buspirone (BuSpar) is a prescription medication used to treat anxiety. It belongs to a group of anti-anxiety drugs called ... Always take buspirone at the same time each day, with or without food.. Buspirone Overdose. An overdose of buspirone may cause: ... Missed Dose of Buspirone. Take buspirone exactly as directed by your doctor.. Dont stop taking buspirone on your own. It may ... Buspirone Warnings. You should not take buspirone if you are taking a monoamine oxidase inhibitor (MAOI), a type of drug used ...
more infohttps://www.everydayhealth.com/drugs/buspirone

Riva-Buspirone - PharmasaveRiva-Buspirone - Pharmasave

Buspirone belongs to the class of medications called anxiolytics, or anti-anxieties. Buspirone is used for the short-term ... Buspirone is not used for everyday anxiety and stress.. This medication may be available under multiple brand names and/or in ... Liver function: Buspirone is broken down by the liver so it can be removed from the body through the kidneys. Liver disease or ... Breast-feeding: It is not known if buspirone passes into breast milk. If you are a breast-feeding mother and are taking this ...
more infohttp://www.pharmasave.com/medications/riva-buspirone/

DOM-Buspirone - Uses, Side Effects, Interactions - MedBroadcast.comDOM-Buspirone - Uses, Side Effects, Interactions - MedBroadcast.com

Buspirone belongs to the class of medications called anxiolytics, or anti-anxieties. Buspirone is used for the short-term ... Buspirone belongs to the class of medications called anxiolytics, or anti-anxieties. Buspirone is used for the short-term ... Buspirone is not used for everyday anxiety and stress.. This medication may be available under multiple brand names and/or in ... Liver function: Buspirone is broken down by the liver so it can be removed from the body through the kidneys. Liver disease or ...
more infohttps://medbroadcast.com/drug/getdrug/dom-buspirone

Buspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.govBuspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.gov

Buspirone Treatment for Marijuana Dependence. The safety and scientific validity of this study is the responsibility of the ... Hypersensitivity to buspirone or any other product component.. *Patients who, in the investigators opinion, would be unable to ... Buspirone. Anti-Anxiety Agents. Tranquilizing Agents. Central Nervous System Depressants. Physiological Effects of Drugs. ... It is hypothesized that buspirone combined with MET and CM will reduce the percent of marijuana-positive urine drug screen ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00875836?recr=Open&cond=%22Marijuana+Abuse%22&rank=10

Buspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.govBuspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.gov

Buspirone Treatment for Marijuana Dependence. The safety and scientific validity of this study is the responsibility of the ... Hypersensitivity to buspirone or any other product component.. *Patients who, in the investigators opinion, would be unable to ... Buspirone. Anti-Anxiety Agents. Tranquilizing Agents. Central Nervous System Depressants. Physiological Effects of Drugs. ... It is hypothesized that buspirone combined with MET and CM will reduce the percent of marijuana-positive urine drug screen ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00875836?recr=Open&cond=%22Marijuana+Abuse%22&rank=20
  • Buspirone has these contraindications: Hypersensitivity to buspirone Metabolic acidosis, as in diabetes Should not be used with MAO inhibitors Severely compromised liver and/or renal function Known side effects associated with buspirone include dizziness, headaches, nausea, nervousness, and paresthesia. (wikipedia.org)
  • In one clinical trial, buspirone was administered to healthy male volunteers at a dosage of 375 mg/day, and produced side effects including nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. (wikipedia.org)
  • Side effects that have been reported by humans taking buspirone include: nausea, headache, dizziness, appetite loss, and restlessness. (marvistavet.com)
  • Buspirone is not considered to be a drug-of-abuse, is safer in overdose than traditional anxiolytics, and is significantly less impairing at therapeutic doses. (wikipedia.org)
  • In the US, Buspirone (buspirone systemic) is a member of the drug class miscellaneous anxiolytics, sedatives and hypnotics and is used to treat Anxiety , Borderline Personality Disorder , Panic Disorder and Sexual Dysfunction - SSRI Induced . (drugs.com)
  • Buspirone is in a class of medications called anxiolytics. (medlineplus.gov)
  • Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. (nih.gov)
  • Buspirone belongs to the class of medications called anxiolytics , or anti-anxieties . (pharmasave.com)
  • The development of buspirone, a member of the azapirone class of anxiolytics, stems from this research. (marvistavet.com)
  • Interpretation of the test is complicated, however, by the fact that buspirone possesses D(2) antagonist and 5-HT(1A) agonist activity, both of which will result in the release of prolactin. (biopsychiatry.com)
  • There was wide variation among individuals both in the absolute response to buspirone and in the proportion that could be attributed to the non-serotonergic agonist action of buspirone (22-82% IQ range). (biopsychiatry.com)
  • Buspirone is relatively well-tolerated, and is not associated with sedation, cognitive and psychomotor impairment, muscle relaxation, physical dependence, or anticonvulsant effects. (wikipedia.org)
  • Because it is impossible to predict which patients may experience sedation with buspirone, those starting this drug should not drive or operate dangerous machinery until they know how the drug will affect them. (encyclopedia.com)
  • Buspirone is able to relieve anxiety with minimal sedation, minimal muscle relaxation, and no addiction potential. (marvistavet.com)
  • Avoid drinking large amounts of grapefruit juice while taking buspirone. (medlineplus.gov)
  • Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. (drugbank.ca)
  • Following oral administration, plasma concentrations of unchanged buspirone are very low and variable between subjects. (nih.gov)
  • Darunavir: The plasma concentrations of buspirone may be elevated when administered concurrently with darunavir. (enone.info)
  • Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models. (nih.gov)
  • Buspirone has moderate affinity for brain D 2 -dopamine receptors. (nih.gov)
  • Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. (drugbank.ca)
  • B. Buspirone does not directly affect benzodiazepine receptors, or GABA receptors. (antidepressantsfacts.com)
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  • It is hypothesized that buspirone combined with MET and CM will reduce the percent of marijuana-positive urine drug screen results in marijuana-dependent individuals as compared to a placebo treatment combined with MET and CM. (clinicaltrials.gov)
  • In veterinary medicine, buspirone has been especially helpful in the treatment of urine marking in cats . (marvistavet.com)
  • A stable-labeled internal standard suitable for quantification of buspirone in urine, serum, and other biological matrices by LC-MS/MS or GC/MS for applications in clinical toxicology, urine drug testing, or forensic analysis. (cerilliant.com)
  • 23. Goetz CM, Krenzelok EP, Lopez G et al: Buspirone toxicity: a prospective study (Abstract 167). (antidepressantsfacts.com)
  • One death has been reported in association with 450 mg buspirone together with alprazolam, diltiazem, alcohol, cocaine. (wikipedia.org)
  • A formulation for preparing Buspirone 2.5-mg/mL Oral Suspension. (ijpc.com)
  • Buspirone HcL should be taken with caution in patients with liver or kidney disease , as well as in pregnant or nursing pets , only being given when the benefits greatly outweigh the inherent risks. (petcarerx.com)