Chemicals and Drugs
BuspironeAnti-Anxiety AgentsSerotonin 5-HT1 Receptor AgonistsSerotonin Receptor Agonists8-Hydroxy-2-(di-n-propylamino)tetralinReceptors, Serotonin, 5-HT1Receptor, Serotonin, 5-HT1ADiazepamSerotonin AntagonistsReceptors, Serotonin
Buspirone
An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
Anti-Anxiety Agents
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Serotonin 5-HT1 Receptor Agonists
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.
Serotonin Receptor Agonists
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
8-Hydroxy-2-(di-n-propylamino)tetralin
A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Receptors, Serotonin, 5-HT1
A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.
Receptor, Serotonin, 5-HT1A
A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.
Diazepam
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
Serotonin Antagonists
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Receptors, Serotonin
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.

Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. (1/150)

The present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1A (serotonin) (5-HT1A) receptor agonist, alnespirone [S-20499, (S)-N-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-HT1A agonist 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT), the partial 5-HT1A agonists ipsapirone and buspirone, and the mixed 5-HT1A/1B agonist eltoprazine. All five agonists exerted effective dose-dependent decreases of offensive aggressive behavior in resident rats; 8-OH-DPAT was the most potent (ID50 = 0.074 mg/kg), followed by eltoprazine (0.24), buspirone (0.72), ipsapirone (1.08), and alnespirone (1.24). However, in terms of selectivity of the antiaggressive effects as determined by the absence of decrements in social interest and general motor activity, alnespirone appeared to be superior. In the defensive aggression test, neither alnespirone nor any of the other four agonists changed defensive behaviors in the intruder rats. The involvement of 5-HT1A receptors in the antiaggressive actions of these drugs was confirmed by showing that the selective 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride), which was inactive alone, fully prevented the antiaggressive effects of alnespirone, 8-OH-DPAT, and buspirone and partly reversed those of ipsapirone and eltoprazine. The data clearly indicate that alnespirone effectively suppresses offensive aggression with an advantageous profile of action compared with other full or partial 5-HT1A agonists. These selective antiaggressive actions of alnespirone are mediated by stimulating 5-HT1A receptors, presumably the somatodendritic autoreceptors at the raphe nuclei. Furthermore, the data provide evidence for a major involvement of these 5-HT1A receptors in the modulation of aggressive behavior by 8-OH-DPAT, ipsapirone, buspirone, and eltoprazine.  (+info)

A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses. (2/150)

The involvement of adenosine on the development of time-dependent reversal of long-term potentiation (LTP) by low-frequency stimulation (LFS) was investigated at Schaffer collateral-CA1 synapses of rat hippocampal slices. A train of LFS (2 Hz, 10 min, 1200 pulses) had no long-term effects on synaptic transmission but produced lasting depression of previously potentiated responses. This reversal of LTP (depotentiation) was observed when the stimulus was delivered +info)

Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists. (3/150)

The 5-HT1A receptor is implicated in depression and anxiety. This receptor couples to G(i) proteins to inhibit adenylyl cyclase (AC) activity but can stimulate AC in tissues (e.g. hippocampus) that express ACII. The role of ACII in receptor-mediated stimulation of cAMP formation was examined in HEK-293 cells transfected with the 5-HT1A receptor, which mediated inhibition of basal and G(s)-induced cAMP formation in the absence of ACII. In cells cotransfected with 5-HT1A receptor and ACII plasmids, 5-HT1A agonists induced a 1. 5-fold increase in cAMP level. Cotransfection of 5-HT1A receptor, ACII, and Galpha(i2), but not Galpha(i1), Galpha(i3), or Galpha(o), resulted in an agonist-independent 6-fold increase in the basal cAMP level, suggesting that G(i2) preferentially coupled the receptor to ACII. The 5-HT1B receptor also constitutively activated ACII. Constitutive activity of the 5-HT1A receptor was blocked by pertussis toxin and the Gbetagamma antagonist, betaCT, suggesting an important role for Gbetagamma-mediated activation of ACII. The Thr-149 --> Ala mutation in the second intracellular domain of the 5-HT1A receptor disrupted Gbetagamma-selective activation of ACII. Spontaneous 5-HT1A receptor activity was partially attenuated by 5-HT1A receptor partial agonists with anxiolytic activity (e.g. buspirone and flesinoxan) but was not altered by full agonists or antagonists. Thus, anxiolytic activity may involve inhibition of spontaneous 5-HT1A receptor activity.  (+info)

Stability-indicating high-performance liquid chromatographic assay of buspirone HCl. (4/150)

The United States Pharmacopoeia high-performance liquid chromatographic (HPLC) assay method of buspirone is not able to discriminate buspirone from its degradation products. The purpose of this work is to develop a sensitive, selective, and validated stability-indicating HPLC assay for the analysis of a buspirone hydrochloride in a bulk drug. Buspirone HCI and its potential impurities and degradation products are analyzed on an Ultrasphere C18 column heated to 40 degrees C using a gradient program that contains monobasic potassium phosphate buffer solution (pH 6.9) and acetonitrile-methanol mixture (13:17) of 35% for 5 minutes, then increased to 54% in 5.5 minutes. The samples are monitored using a photo-diode array detector and integrated at 244 and 210 nm. The stress testing of buspirone HCI shows that buspirone acid hydrochloride is the major degradation product. The developed method shows a separation of buspirone degradation product and its potential impurities in one run. The stability of buspirone HCI is studied under accelerated conditions in order to provide a rapid indication of differences that might result from a change in the manufacturing process or source of the sample. The forced degradation conditions include the effect of heat, moisture, light, acid-base hydrolysis, sonication, and oxidation. The compatibility of buspirone HCI with some pharmaceutical excipients is studied under stress conditions. The linear range of buspirone HCI is between 5 and 200 ng/microL with a limit of quantitation of 2.5 ng/microL. The intraassay percentage deviation is not more than 0.38%, and the day-to-day variation was not more than 0.80%. The selectivity, repeatability, linearity, range, accuracy, sample solution stability, ruggedness, and robustness show acceptable values.  (+info)

Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. (5/150)

The purpose of our study was to test the hypothesis that 5-hydroxytryptamine (5-HT)(1A) receptor agonists counteract morphine-induced respiratory depression. Studies were conducted in anesthetized rats, and respiratory activity was monitored with diaphragm electromyography. Morphine was administered i.v. in doses that produce apnea. Once apnea was established, i.v. administration of the 5-HT(1A) receptor agonist drug 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) at 10 or 100 microgram/kg restored normal breathing in each animal (n = 24). This antagonistic effect of 8-OH-DPAT on morphine-induced respiratory depression was observed in both spontaneously breathing and artificially ventilated animals. Results obtained with 8-OH-DPAT were mimicked by buspirone (50 microgram/kg i.v.), another 5-HT(1A) receptor agonist drug. Pretreatment with 4-(2'-methoxyphenyl)-1-[2'[N-(2'-pyridinyl]-p-iodo-benzamido]ethyl]pi perazine, an antagonist of 5-HT(1A) receptors, prevented 8-OH-DPAT from counteracting morphine-induced apnea. These results indicate that activation of central nervous system 5-HT(1A) receptors is an effective way of reversing morphine-induced respiratory depression. Most important, this is the third model of disturbed respiratory function in which drugs that stimulate 5-HT(1A) receptors have been shown to restore breathing to near-normal levels.  (+info)

Contribution of development to buspirone effects on REM sleep: a preliminary report. (6/150)

In order to assess whether development influences the regulation of rapid eye movement (REM) sleep by serotonergic (5-HT) systems, the REM sleep responses to the partial 5-HT(1A) agonist, buspirone, were assessed in 14 normal adolescent and adult volunteers. Subjects were studied on three separate sessions for three consecutive nights. On the second night of each session, subjects received placebo or one of two doses of buspirone (0.14 mg/kg and 0.28 mg/kg, orally). Night 3 was considered the "recovery" night. In adolescents, both doses of buspirone significantly delayed REM latency. In contrast, low-dose buspirone had no effect on REM latency in the adults, and there was only a tendency for prolongation of REM latency with the higher dose. Other measures of REM sleep on nights 2 and 3 were comparable between the two groups. These preliminary results suggest that post-synaptic 5-HT(1A) acceptor-coupled REM sleep responses, particularly REM latency, may be relatively greater in youngsters than in adults, possibly due to reduced presynaptic input. The findings are discussed in relation to the age-dependent expression of REM sleep changes associated with depression.  (+info)

Liquid chromatographic method for the analysis of buspirone HCl and its potential impurities. (7/150)

An accurate, reproducible, and sensitive method for the determination of buspirone HCl and its potential impurities is developed and validated. The validated liquid chromaography method is conducted to meet the Food and Drug Administration/ International Conference on Harmonization requirements for the analysis of buspirone HCI in the presence of its impurities. Five buspirone HCI potential impurities, including 1-(2-pyrimidinyl)-piperazine (I), propargyl chloride (II), 3,3'-tetramethylene glutarimide (III), propargyl glutarimide (IV), and the Mannich base-condensate of I-IV fumarate (V), are separated using a microBondapack C18 column by gradient elution with a flow rate 2.0 mL/min. The initial mobile phase composition is 90:10 (v/v) 10mM KH2PO4 (pH 6.1)-acetonitrile. After a 1-min initial hold, a linear gradient is performed in 26 min to 35:65 (v/v) 10mM KH2PO4 (pH 6.1)-acetonitrile. The samples are detected at 210 and 240 nm using a photo-diode array detector. The linear range of detection for buspirone HCI was between 1.25 ng/microL and 500 ng/microL, with a limit of quantification of 1.25 ng/microL. The linearity, range, peak purity, selectivity, system performance parameters, precision, accuracy, and robustness for all of the impurities were also shown to have acceptable values.  (+info)

Behavioral effects of plant-derived essential oils in the geller type conflict test in mice. (8/150)

The present study was conducted to further explore plant-derived essential oils that possess an anticonflict effect using the Geller type conflict test in ICR mice. The benzodiazepine anxiolytic diazepam increased the response (lever pressing) rate during the alarm period (i.e., an anticonflict effect), but the 5-HT1A partial agonist buspirone did not. Oils of juniper, cypress, geranium and jasmine did not produce any effect in this test. Frankincense oil decreased the response rate during the safe period at 1600 mg/kg, but did not exhibit any effect on the response rate during the alarm period. In contrast, lavender oil increased the response rate during the alarm period in a dose-dependent manner in the same manner as diazepam. These results indicate that not only rose oil but also lavender oil possess an anticonflict effect in mice.  (+info)

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BUSPIRONE HYDROCHLORIDE USP - Pharmaceuticals Industry - Web of PharmaBUSPIRONE HYDROCHLORIDE USP - Pharmaceuticals Industry - Web of Pharma
Prepare 0.1mg/ml of buspirone hydrochloride from the sample stock solution and 0.025mg/ml of propylparaben from the internal standard solution in purified water ...
https://www.webofpharma.com/2018/12/buspirone-hydrochloride-usp.html
Buspirone hydrochloride / buspirone hydrochloride NDA 204582 international drug patent coverage, generic alternatives and...Buspirone hydrochloride / buspirone hydrochloride NDA 204582 international drug patent coverage, generic alternatives and...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Buspirone hydrochloride / buspirone hydrochloride NDA 075022 international drug patent coverage, generic alternatives and...Buspirone hydrochloride / buspirone hydrochloride NDA 075022 international drug patent coverage, generic alternatives and...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Buspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.govBuspirone Treatment for Marijuana Dependence - Full Text View - ClinicalTrials.gov
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence. This study will evaluate the efficacy of buspirone for reducing marijuana use in marijuana-dependent adults. A contingency management (CM) intervention and motivational enhancement therapy (MET) will be incorporated to encourage study engagement and retention. It is hypothesized that buspirone combined with MET and CM will reduce the percent of marijuana-positive urine drug screen results in marijuana-dependent individuals as compared to a placebo treatment combined with MET and CM ...
https://clinicaltrials.gov/ct2/show/NCT00875836?recr=Open&cond=%22Marijuana+Abuse%22&rank=20
Effect of buspirone and its metabolite 1-(2-Pyrimydinyl)-piperazine on hippocampal serotoninergic system, studied in freely...
TY - JOUR. T1 - Effect of buspirone and its metabolite 1-(2-Pyrimydinyl)-piperazine on hippocampal serotoninergic system, studied in freely moving rats. AU - De Simoni, Maria Grazia. AU - Imeri, Luca. AU - De Luigi, Ada. AU - Fodritto, Fabio. AU - Garattini, Silvio. PY - 1990. Y1 - 1990. N2 - The effects of the anxiolytic drug buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1PP) were studied on the serotoninergic system in the hippocampus of freely moving rats. Pulse voltammetry was used in association with chronically implanted carbon fiber microelectrodes to record 5HIAA, the serotonin metabolite in the extracellular space, almost continuously. Buspirone, 2.5 mg/kg i.p. was ineffective, but the dose of 10 mg/kg lowered 5HIAA between about 45 and 150 min; the same decrease was obtained with 40 mg/kg. This effect can be explained by an agonistic action on 5HT1 A receptors. The metabolite 1PP, which displays α2 adrenoceptor blocking properties, either had no effect or raised ...
https://moh-it.pure.elsevier.com/en/publications/effect-of-buspirone-and-its-metabolite-1-2-pyrimydinyl-piperazine
buspirone - WellSpan Health Librarybuspirone - WellSpan Health Library
Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms. Buspirone is not an anti-psychotic medication and...
https://www.wellspan.org/health-library/Document.aspx?id=d00182a1
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Buspirone, a clinically effective anxiolytic, has not shown robust effects consistently in procedures used traditionally with rodents and nonhuman primates to evaluate potential antianxiety activity. When key pecking by pigeons was maintained by food and was punished alternately under one component of a multiple schedule by the presentation of electric shock (conflict procedure), buspirone (0.03-10.0 mg/kg i.m.) produced increases in punished responding that were up to 30 times those of the control response rate. These doses did not affect or decreased unpunished responding. A buspirone analog, MJ 13805 (gepirone) produced effects similar to buspirone, although unpunished responding was slightly more sensitive to the rate-decreasing effects of MJ 13805 than to those of buspirone. A metabolite of buspirone, 1-pyrimidinyl piperazine (1-PP; MJ 13653), did not affect key pecking across a wide dose range (0.01-3.0 mg/kg i.m.), although slight decreases in both punished and unpunished responding ...
https://jpet.aspetjournals.org/content/238/3/1009
Buspirone | Encyclopedia.com
Buspirone Definition Buspirone is an anti-anxiety (anxiolytic) drug sold in the United States [1] under the brand name of BuSpar. It is also available under its generic name.
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Bupropion or Buspirone May Augment Citalopram ResponseBupropion or Buspirone May Augment Citalopram Response
Sustained-Release Bupropion or Buspirone May Augment Citalopram Response March 23, 2006 by Laurie Barclay, MD, Medscape Patients with depression not responding adequately to citalopram may respond to the addition of either bupropion or buspirone, with the former having certain advantages, according to the results of a randomized study reported in the March 23 issue of The New England Journal of Medicine. Although clinicians frequently add a second medication to an initial, ineffective
https://forum.psychlinks.ca/showthread.php?3836-Bupropion-or-Buspirone-May-Augment-Citalopram-Response
Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression - Full Text View - ClinicalTrials.govBuspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression - Full Text View - ClinicalTrials.gov
PURPOSE OF PROJECT: To study the effect expressed by persons with TBI through assessment of buspirone effectiveness for post-traumatic irritability and aggression and development of an irritability/aggression impact measure.. SUMMARY OF PROJECT: It is anticipated that 74 subjects with 74 corresponding subject observers will be recruited for the treatment study. Subjects will be recruited from community and self-referrals.. Interested potential participants will be scheduled for an in-person screening visit. Subjects who consent and qualify will be randomized in a 1:1 ratio, buspirone or placebo. Stratification to randomization group will occur based on the presence of major or minor depression (defined by PHQ-9 total score ,5). Randomized subjects will receive active treatment or placebo. There will be 4 clinic visits. Visits will occur at baseline, for consenting and screening, day 35, day 63 and day 91. At all 4 clinic visits, both the subject and the observer will be given questionnaires ...
https://clinicaltrials.gov/show/NCT01821690
FRI0489 Improvement of Lower Esophageal Sphincter Function in Systemic Sclerosis After Long Term Administration of Buspirone,...FRI0489 Improvement of Lower Esophageal Sphincter Function in Systemic Sclerosis After Long Term Administration of Buspirone,...
Results CT evaluations revealed that 12 patients had supra-, and 21 had infra-aortic esophagus dilatation (mean diameters 12.4±5.3 and 22.5±11.0 mm, respectively, normal ,10 mm). Baseline esophageal hypomotility was observed in 68% and hypotensive LES in 75% of patients. Most intense symptoms were heartburn and regurgitation followed by dysphagia and retrosternical pain (mean scores 39±30, 37±24, 23±27 and 10±24 respectively). After 4 weeks of buspirone, LES resting pressure increased from 6.8±2.7 to 10.6±4.3 mmHg (p=0.007). Percent improvement was less prominent in patients with supra-aortic esophagus dilatation (29.2±19.8% versus 83.9±38.1% in patients without dilatation, p=0.037), whereas bivariate regression analysis revealed a negative correlation between individual increases of resting LES pressure and supra-aortic diameter (r=-0,613 p=0.058), indicating that buspirone exerts a greater effect in patients with less affected esophagus. No significant changes were noted on other ...
http://ard.bmj.com/content/74/Suppl_2/605.2
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In a single-dose study using 14C-labeled buspirone, 29% to 63% of the dose was excreted in the urine within 24 hours, primarily as metabolites; fecal excretion accounted for 18% to 38% of the dose. The average elimination half-life of unchanged buspirone after single doses of 10 mg to 40 mg is about 2 to 3 hours. ...
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Behavioral effects of 5-｛3-[((2,I,S,/I,)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy｝-1, 3-benzodioxole HCl (MKC-242), a novel 5-HT,SUB,1A,/SUB,-receptor agonist, were evaluated using animal models of anxiety and obsessive compulsive disorder and compared against reference compounds. MKC-242 suppressed foot shock-induced fighting behavior without loss of motor coordination in mice as the reference compounds did. The ED,SUB,50,/SUB, values of MKC-242, buspirone, tandospirone and diazepam were 1.7, 42, 80 and 2.0 mg/kg, p.o., respectively. The duration of the suppression of fighting by MKC-242 was longer than those of buspirone and tandospirone and comparable to that of diazepam. Similar results were also obtained with the water-lick conflict test in rats. The plasma concentration of MKC-242 in rats was much higher than the reported value of buspirone during 0.25 - 6 hr after oral administration. In addition, MKC-242 reduced marble burying behavior without reduction of motor activity. ...
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Laboratory abnormalities in ME/CFS include abnormal SIgA; weakly positive IgG3 (linked to gastrointestinal tract disorders); positive IgM; increased T4:T8 ratio (which always corresponds with disease severity); very low numbers of NK cells, with decreased cytolytic activity; low levels of circulating immune complexes (two-thirds of ME patients have insoluble circulating immune complexes); autoantibodies (especially antinuclear and smooth muscle); a particular HLA antigen expression; PCR evidence of abnormalities in muscle; a positive water loading test with erratic arginine-vasopressin release; a significant prolactin release in response to a single buspirone challenge; positive SPECT scans (which show reduced blood flow through the brain stem in a particular pattern not found in any other illness or disease process apart from ME/CFS - QJMed 1995:88:767-773); abnormal fMRI scans; abnormal EEG (80% of ME patients show prolonged jitter); a positive VP1 test; positive mast cells; low pancreatic ...
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Lesopitron - WikipediaLesopitron - Wikipedia
Lesopitron (E-4424) is a selective full agonist of the 5-HT1A receptor which is structurally related to the azapirones.[1] In 2001 it was under development by Esteve as an anxiolytic for the treatment of generalized anxiety disorder (GAD).[2][3] It made it to phase II clinical trials but was apparently discontinued as no new information on lesopitron has surfaced since.[2][3] ...
https://en.wikipedia.org/wiki/Lesopitron
What Are the Different Types of Anxiolytic Drugs?What Are the Different Types of Anxiolytic Drugs?
There are several different classes of anxiolytic drugs, including benzodiazepines, antidepressants, certain beta-blockers, and...
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Lesopitron - WikipediaLesopitron - Wikipedia
Haj-Dahmane S, Jolas T, Laporte AM et al. (April 1994). Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. European Journal of Pharmacology 255 (1-3): 185-96. PMID 8026543. doi:10.1016/0014-2999(94)90097-3. Cite uses deprecated parameter ...
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Acetic acid, (3,4-dihydro-5-nitro-4-oxo-6-pyrimidinyl)hydrazideAcetic acid, (3,4-dihydro-5-nitro-4-oxo-6-pyrimidinyl)hydrazide
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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BuspironeBuspirone
... is the INN, BAN, DCF, and DCIT of buspirone, while buspirone hydrochloride is its USAN, BANM, and JAN. Buspirone was ... "Buspirone - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022. "BUSPIRONE HCL (buspirone hydrochloride) tablet [Watson ... Media related to Buspirone at Wikimedia Commons "Buspirone". Drug Information Portal. U.S. National Library of Medicine. Portal ... Buspirone also has very weak and probably clinically unimportant affinity for the α1-adrenergic receptor. However, buspirone ...
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List of side effects of buspironeList of side effects of buspirone
Side effects of buspirone by incidence include: Very common (>10% incidence) Dizziness/lightheadedness Headache Somnolence ( ...
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AnxiolyticAnxiolytic
Buspirone is indicated for GAD, which has much slower onset but with the advantage of less sedating and withdrawal effects. ... Buspirone (Buspar) is a 5-HT1A receptor agonist used to treated generalized anxiety disorder. If an individual has taken a ... "Prior benzodiazepine use and buspirone response in the treatment of generalized anxiety disorder". The Journal of Clinical ... buspirone; antiepileptics; antipsychotics; and beta-adrenoceptor antagonists. Antidepressants including selective serotonin ...
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List of dopaminergic drugsList of dopaminergic drugs
Buspirone • Butaclamol • Ecopipam • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) • Eticlopride • Fananserin • L- ...
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Brazilian Controlled Drugs and Substances ActBrazilian Controlled Drugs and Substances Act
BUSPIRONE 16. BUTAPERAZINE 17. BUTRIPTILINE 18. CAPTODIAMINE 19. CARBAMAZEPINE 20. CAROXAZONE 21. CETAMINE 22. CYCLARBAMATE 23 ...
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Attention deficit hyperactivity disorder managementAttention deficit hyperactivity disorder management
"buspirone (Rx) - BuSpar, Buspirex". Medscape Drugs & Diseases. Malhotra, S; Santosh, PJ (April 1998). "An open clinical trial ... Mohammadi, MR; Hafezi, P; Galeiha, A; Hajiaghaee, R; Akhondzadeh, S (November 2012). "Buspirone versus Methylphenidate in the ... Davari-Ashtiani, R; Shahrbabaki, ME; Razjouyan, K; Amini, H; Mazhabdar, H (2010). "Buspirone Versus Methylphenidate in the ... Atomoxetine Plus Buspirone, or Placebo in Adults With ADHD". The Journal of Clinical Psychiatry. 73 (4): 445-450. doi:10.4088/ ...
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Hypoactive sexual desire disorderHypoactive sexual desire disorder
Howland RH (2015). "Buspirone: Back to the Future". J Psychosoc Nurs Ment Health Serv. 53 (11): 21-4. doi:10.3928/02793695- ... The same is true for the anxiolytic, buspirone, which is a 5-HT1A receptor agonist similarly to flibanserin. Testosterone ...
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NerisopamNerisopam
Comparison with chlordiazepoxide and buspirone". Acta Physiologica Hungarica. 79 (2): 153-61. PMID 1363928. Palkovits M, Baffi ...
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GirisopamGirisopam
Comparison with chlordiazepoxide and buspirone". Acta Physiologica Hungarica. 79 (2): 153-61. PMID 1363928. Horváth EJ, Salamon ...
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TandospironeTandospirone
It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone. ... Cybulski, J., Chilmonczyk, Z., Szelejewski, W., Wojtasiewicz, K., Wróbel, J. T. (1992). "An Efficient Synthesis of Buspirone ...
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AzapironeAzapirone
Buspirone is being investigated for this purpose as well. Gepirone was abandoned after FDA rejection. Side effects of ... Sumiyoshi T, Park S, Jayathilake K, Roy A, Ertugrul A, Meltzer HY (September 2007). "Effect of buspirone, a serotonin1A partial ... June 1990). "Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment ... Bouwer C, Stein DJ (April 1997). "Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in ...
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Grapefruit-drug interactionsGrapefruit-drug interactions
Grapefruit juice increased peak and AUC plasma concentrations of buspirone 4.3- and 9.2-fold, respectively, in a randomized, 2- ... "Grapefruit juice substantially increases plasma concentrations of buspirone". Clinical Pharmacology and Therapeutics. 64 (6): ... Metabolized into norbuprenorphine by CYP3A4 Buspirone (Buspar): ...
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Selective serotonin reuptake inhibitorSelective serotonin reuptake inhibitor
SSRI and SNRI antidepressants may cause jaw pain/jaw spasm reversible syndrome (although it is not common). Buspirone appears ... Prisco, V.; Iannaccone, T.; Di Grezia, G. (2017-04-01). "Use of buspirone in selective serotonin reuptake inhibitor-induced ... Albayrak, Yakup; Ekinci, Okan (2011). "Duloxetine-induced nocturnal bruxism resolved by buspirone: case report". Clinical ... John's wort Yohimbe Tricyclic antidepressants (TCAs) Serotonin-norepinephrine reuptake inhibitors (SNRIs) Buspirone Triptan ...
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Dopamine receptor D2Dopamine receptor D2
Lechin F, van der Dijs B, Jara H, Orozco B, Baez S, Benaim M, Lechin M, Lechin A (1998). "Effects of buspirone on plasma ... commonly employed in positron emission tomography studies Typical antipsychotics SV 293 Yohimbine Buspirone D2 presynaptic ...
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Cerebellar ataxiaCerebellar ataxia
Additionally, mild to moderate cerebellar ataxia may be treatable with buspirone. It is thought that the buspirone increases ... Trouillas, Paul; Xie, Jing; Adeleine, Patrice (1996). "Treatment of cerebellar ataxia with buspirone: a double-blind study". ...
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List of psychotropic medicationsList of psychotropic medications
Buspar (buspirone) - an anxiolytic used to treat generalized anxiety disorder. Belsomra (Suvorexant) - used to treat insomnia. ...
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AgonistAgonist
E.g. buspirone is a selective agonist for serotonin 5-HT1A. Partial agonists (such as buspirone, aripiprazole, buprenorphine, ...
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Raphe nucleiRaphe nuclei
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4-Chlorobutyronitrile4-Chlorobutyronitrile
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Benzodiazepine withdrawal syndromeBenzodiazepine withdrawal syndrome
Buspirone augmentation was not found to increase the discontinuation success rate. Caffeine may worsen withdrawal symptoms ... Prospective Comparison of Clorazepate and Buspirone". Archives of General Psychiatry. 45 (5): 444-50. doi:10.1001/archpsyc. ...
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HydroxyzineHydroxyzine
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Post viral cerebellar ataxiaPost viral cerebellar ataxia
However, the following drugs may be prescribed: clonazepam, amantadine, gabapentin, or buspirone. Occupational or physical ...
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FlesinoxanFlesinoxan
8-OH-DPAT Befiradol Buspirone Eptapirone Schoeffter P, Hoyer D (November 1988). "Centrally acting hypotensive agents with ...
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UmespironeUmespirone
I. Antipsychotic and anxiolytic activity in comparison with chlorpromazine, clozapine, diazepam and buspirone". ...
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Effects of cannabisEffects of cannabis
The drugs buspirone and rimonabant have shown some success in helping maintain cannabis abstinence. There is evidence that long ...
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5-HT1A receptor5-HT1A receptor
... agonists like buspirone and flesinoxan show efficacy in relieving anxiety and depression, and buspirone and ... Cohn JB, Rickels K (1989). "A pooled, double-blind comparison of the effects of buspirone, diazepam and placebo in women with ... Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (March 1995). "Buspirone, but not sumatriptan, induces miosis in humans: ... αMT Aripiprazole Asenapine Bacoside Bay R 1531 Befiradol Binospirone Brexpiprazole Bufotenin Buspirone (postsynaptic 5-HT1A) ...
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PyrimidinylpiperazinePyrimidinylpiperazine
A number of pyrimidinylpiperazine derivatives are drugs, including: Buspirone - anxiolytic Dasatinib - anticancer agent ... and buspirone on locus coeruleus neuronal activity". Eur. J. Pharmacol. 459 (1): 17-26. doi:10.1016/s0014-2999(02)02814-5. PMID ... A comparison to buspirone and its metabolite, 1-pyrimidinylpiperazine". European Neuropsychopharmacology. 7: S149-S150. doi: ... "Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors". Int ...
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Atypical depressionAtypical depression
Antidepressant response can often be enhanced with supplemental medications, such as buspirone, bupropion, or aripiprazole. ...
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Epigenetics of anxiety and stress-related disordersEpigenetics of anxiety and stress-related disorders
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EptapironeEptapirone
In addition, the efficacy of eptapirone in this assay was more evident than that of buspirone, ipsapirone, and flesinoxan. ... November 2005). "The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans". Journal of ... In this assay, unlike the other drugs screened, buspirone actually increased the immobility time with a single administration, ... In the Porsolt forced swimming test, eptapirone was found to suppress immobility more robustly than buspirone, ipsapirone, ...
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Buspirone: MedlinePlus Drug InformationBuspirone: MedlinePlus Drug Information
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BuSpar14
  • BuSpar, also known as buspirone, is often prescribed as an alternative anti-anxiety medication to benzodiazepines. (sunshinebehavioralhealth.com)
  • On buspar (buspirone) for over a week, less anxiety but more anger, this is unlike me. (healthtap.com)
  • Buspar ( buspirone ) can take 3-6 weeks before full anti- anxiety effects appear. (healthtap.com)
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  • My dr gave me Buspar (buspirone) for anxiety? (healthtap.com)
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  • I take Buspar (buspirone) 10 mg once daily for anxiety for 24 days, have had 4 panic attacks in the last week what should I do? (healthtap.com)
  • Buspirone (brand names: BuSpar®, Bustab®) is an antianxiety medication used to treat behavior disorders such as fears, phobias, and social anxieties. (paradisevethospital.com)
  • Buspar is a brand name for the generic drug called buspirone hydrochloride (HCL). (khealth.com)
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  • Buspirone, also known as BuSpar and Bustab, is a medication that treats anxiety. (ourfitpets.com)
  • Buspirone - Generic is the generic alternative to Buspar. (onlinepharmaciescanada.com)
Hydrochloride17
  • Buspirone hcl has active ingredients of buspirone hydrochloride . (ehealthme.com)
  • Buspirone hydrochloride, a compound with novel chemical structure, has been reported to be anxiolytic in man. (northwestern.edu)
  • In man, buspirone hydrochloride at doses of 30,60, and 90 mg orally significantly elevated plasma prolactin (PRL) and growth hormone (GH) concentrations. (northwestern.edu)
  • 0' on the other side, contains 10 mg buspirone hydrochloride. (rxhealthmed.ca)
  • The Buspirone Hydrochloride Tablets market revenue was xx.xx Million USD in 2013, grew to xx.xx Million USD in 2017, and will reach xx.xx Million USD in 2023, with a CAGR of x.x% during 2018-2023. (maiaresearch.com)
  • Based on the Buspirone Hydrochloride Tablets industrial chain, this report mainly elaborate the definition, types, applications and major players of Buspirone Hydrochloride Tablets market in details. (maiaresearch.com)
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  • The Buspirone Hydrochloride Tablets market can be split based on product types, major applications, and important regions. (maiaresearch.com)
  • There are 13 Chapters to thoroughly display the Buspirone Hydrochloride Tablets market. (maiaresearch.com)
  • Chapter 2: Buspirone Hydrochloride Tablets Industry Chain Analysis, Upstream Raw Material Suppliers, Major Players, Production Process Analysis, Cost Analysis, Market Channels and Major Downstream Buyers. (maiaresearch.com)
  • Chapter 3: Value Analysis, Production, Growth Rate and Price Analysis by Type of Buspirone Hydrochloride Tablets. (maiaresearch.com)
  • Chapter 4: Downstream Characteristics, Consumption and Market Share by Application of Buspirone Hydrochloride Tablets. (maiaresearch.com)
  • Chapter 5: Production Volume, Price, Gross Margin, and Revenue ($) of Buspirone Hydrochloride Tablets by Regions (2013-2018). (maiaresearch.com)
  • Chapter 6: Buspirone Hydrochloride Tablets Production, Consumption, Export and Import by Regions (2013-2018). (maiaresearch.com)
  • Chapter 7: Buspirone Hydrochloride Tablets Market Status and SWOT Analysis by Regions. (maiaresearch.com)
  • Chapter 8: Competitive Landscape, Product Introduction, Company Profiles, Market Distribution Status by Players of Buspirone Hydrochloride Tablets. (maiaresearch.com)
  • Chapter 9: Buspirone Hydrochloride Tablets Market Analysis and Forecast by Type and Application (2018-2023). (maiaresearch.com)
Dosage2
  • Buspirone is not FDA-approved for use by anyone younger than 18 years old, but this medicine has been used in children and adolescents under close medical supervision and at the appropriate dosage. (fioricet.name)
  • Unfortunately, buspirone can be toxic to cats if they eat a dosage larger than what they should have. (ourfitpets.com)
Medication9
  • Buspirone is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for psychotic disorders. (fioricet.name)
  • If you have switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. (fioricet.name)
  • Buspirone is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder. (deliverypharmacyke.com)
  • DRUG CLASS AND MECHANISM: Buspirone is an antianxiety medication that works by stimulating serotonin type 1A receptors on nerves thereby altering the chemical messages that nerves transmit to each other. (psychlinks.ca)
  • Since it takes about two weeks of taking buspirone for you to see any effects, this medication is not used to treat acute anxiety. (khealth.com)
  • Buspirone is not a medication that is ideal for everyone with GAD or other anxiety symptoms. (khealth.com)
  • If you are having trouble sleeping, your doctor may suggest a different medication or recommend a sleep aid that is safe to take with buspirone. (drsprays.com)
  • Buspirone is a medication that is sometimes prescribed for sleep disorders, so you may be wondering if it is safe to take a sleep aid with buspirone. (drsprays.com)
  • Buspirone is usually prescribed in tablet form in a dose that's appropriate for the human or cat taking the medication. (ourfitpets.com)
Tablets3
  • tell your doctor and pharmacist if you are allergic to buspirone, any other medications, or any of the ingredients in buspirone tablets. (medlineplus.gov)
  • Some buspirone tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. (fioricet.name)
  • Buspirone tablets should be stored at room temperature in tight containers and protected from light. (paradisevethospital.com)
Anxiolytic buspirone1
  • These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome. (wustl.edu)
Bupropion1
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Allergic2
Serotonin2
  • Although case reports andopen studies have reported augmentation with buspirone to bebeneficial in the treatment of depression refractory to treatmentwith a selective serotonin reuptake inhibitor (SSRI), a recentlypublished randomized, placebo-controlled, double-blind studyfailed to show superiority of buspirone over placebo in thisrespect. (psychiatrist.com)
  • What is known is that buspirone has effects on chemical messengers in the brain including serotonin and dopamine neurotransmitters. (khealth.com)
Prescription7
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  • According to the FDA prescription information for buspirone, the exact mechanism of action, or how this drug works, is not fully understood. (khealth.com)
  • You could get Teva Buspirone delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. (pocketpills.com)
Behavior2
  • Pretreatment with melatonin (2.5 mg/kg and 5 mg/kg), buspirone (5 mg/kg and 10 mg/kg), and melatonin (2.5, 5 mg/kg) in combination with buspirone (5 mg/kg) showed significant improvement in behavioral parameters such as increase in body weight, increase in locomotor activity, and reduction in anxiety like behavior. (who.int)
  • Effects of buspirone, diazepam, and zolpidem on open field behavior, and brain [3H]muscimol binding after buspirone pretreatment. (bvsalud.org)
Antianxiety1
  • DOSING: Unlike antianxiety medications of the benzodiazepine class which are effective after a single dose, effectiveness with buspirone may require two or more weeks of treatment. (psychlinks.ca)
Anti-anxiety2
  • Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. (fioricet.name)
  • Lately, I am starting to feel like trying a different medicine and read that Buspirone may work as an antidepressant/anti-anxiety medicine. (psychlinks.ca)
Pharmacy2
  • Compare buspirone prices available at Canadian and international online pharmacies with local U.S. pharmacy coupon prices. (pharmacychecker.com)
  • Many cult French pharmacy brands are now available online in the buy buspirone for cats canada. (onlinehome.us)
Generalized anxiety3
  • Buspirone is used for the short-term relief of excessive anxiety for people with generalized anxiety disorder. (rxhealthmed.ca)
  • The Food and Drug Administration approved the use of buspirone for generalized anxiety disorder (GAD) in 1986. (psychlinks.ca)
  • Buspirone is a unique anxiolytic that differs from benzodiazepines in that it does not exert anticonvulsant or muscle-relaxing effects for generalized anxiety disorder (GAD). (medscape.com)
Agonists1
  • In mammals both 5-HT1A and CB agonists, such as buspirone and WIN55,212-2, reduce anxious behaviors. (cdc.gov)
Maintenant1
  • Découvrez maintenant la parapharmacie en ligne buy buspirone for cats canada . (onlinehome.us)
Mechanism of act1
  • The mechanism of action of buspirone is unknown. (medscape.com)
Dose2
  • Your doctor may start you on a low dose of buspirone and gradually increase your dose, not more often than once every 2 to 3 days. (medlineplus.gov)
  • Buspirone and go by pfizer makes two kinds of a two-milligram dose as xanax bars are separated by sandoz pharmaceuticals group. (ihsgonline.com)
Symptoms of anxiety2
  • Buspirone is used to treat anxiety disorders or in the short-term treatment of symptoms of anxiety. (medlineplus.gov)
  • PRESCRIBED FOR: Buspirone is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. (psychlinks.ca)
Ligne2
Benzodiazepine1
  • It may be that buspirone and benzodiazepine drugs stimulate GH secretion by a common mechanism that is related to their anxiolytic actions. (northwestern.edu)
Class of medications called2
  • Buspirone is in a class of medications called anxiolytics. (medlineplus.gov)
  • Buspirone belongs to the class of medications called anxiolytics , or anti-anxieties . (rxhealthmed.ca)
Depression1
  • Since these receptors influence various neurological processes such as anxiety and depression, among other roles, this allows buspirone to alleviate anxiety. (khealth.com)
Medications3
  • Many other medications may also interact with buspirone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • You may also be prescribed buspirone if you have found that other medications you have been taking are not working or have too many side effects. (khealth.com)
  • Buspirone is a member of the azapirone class of medications, which includes other anxiolytic, antidepressant, and antipsychotic medications. (khealth.com)
Grapefruit1
  • Avoid drinking large amounts of grapefruit juice while taking buspirone. (medlineplus.gov)
Urine1
  • For the determination of trace quantities of Buspirone and/or other metabolites in human urine, blood or oral fluid. (neogen.com)
Acute1
  • With acute exposure to the 5-HT1A partial-agonist buspirone (50 mg/L), or dietary exposure to WIN55,212-2 (7 µg/week) zebrafish spent more time in and/or entered white arms more often than controls (p (cdc.gov)
Doses2
  • It also comes in 15mg bars that are scored and can be broken into three 5mg pieces, which is quite economical.I forgot to mention buspirone is taken 3 times a day by many people in varying doses. (drugs.com)
  • Buspirone usually is given as three doses daily. (psychlinks.ca)
Dizziness2
  • Buspirone - Head whooshing/dizziness, Is this a normal side effect? (drugs.com)
  • Additionally, taking a sleep aid with buspirone may increase the risk of developing side effects such as headaches, gastrointestinal problems, and dizziness. (drsprays.com)
Room temperature1
  • Store Teva Buspirone at room temperature, protect it from light and moisture, and keep it out of the reach of children. (pocketpills.com)
Medicine1
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Drugs1
  • eHealthMe is studying from 7,642 Buspirone hcl users for its effectiveness, alternative drugs and more. (ehealthme.com)
Treatment2
  • It cannotbe excluded that augmentation with buspirone may speed up theantidepressive response of patients refractory to treatment withfluoxetine or citalopram. (psychiatrist.com)
  • Biochemical parameters estimation also revealed similar results such as significant attenuation of lipid peroxidation and nitrite concentration and significant elevation of glutathione and catalase levels following treatment with melatonin (2.5, 5 mg/kg) and buspirone (5,10 mg/kg) and melatonin (2.5, 5 mg/kg) in combination with buspirone (5 mg/kg) as compared to their effect per se. (who.int)
Side5
  • Buspirone may cause side effects. (medlineplus.gov)
  • Will buspirone side effect of anger pass? (healthtap.com)
  • It is created by eHealthMe based on reports of 6,839 people who have side effects when taking Buspirone hcl from the FDA, and is updated regularly. (ehealthme.com)
  • 6,839 people reported to have side effects when taking Buspirone hcl. (ehealthme.com)
  • If you experience any side effects from taking a sleep aid with buspirone, be sure to talk to your doctor. (drsprays.com)
Clonazepam1
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Behavioral1
  • The objective of the present study was to investigate the protective effects of melatonin and buspirone and their combinations against the biochemical and behavioral alterations induced by 48 hrs sleep deprivation in mice. (who.int)
Cats6
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Severe1
  • Patients with severe depressivesymptoms may benefit from augmentation with buspirone. (psychiatrist.com)
Significantly2
  • 30) showed a significantly greaterreduction in MADRS score (p = .026) in the buspirone group ascompared with placebo. (psychiatrist.com)
  • Ethanol intake is significantly suppressed by zimelidine, bromocriptine, buspirone, and lithium carbonate, pharmacological agents that have been shown to be beneficial in controlling ethanol intake in alcohol-dependent humans. (nih.gov)
Drug2
  • Buspirone is now only available as a cheaper generic drug in the United States since the patent held by BMS expired in 2001. (khealth.com)
  • Your doctor may have suggested Teva Buspirone for conditions other than those listed in these drug information articles. (pocketpills.com)
Alcohol2
  • Do not drink alcohol while taking buspirone. (medlineplus.gov)
  • La guía busca contestar las siguientes preguntas clínicas elaborando recomendaciones basadas en evidencia, En pacientes mayores de 18 años con abuso o dependencia del alcohol, ¿cuáles son los criterios clínicos más importantes para predecir el desarrollo de un síndrome de abstinencia? (bvsalud.org)
Pregnant1
  • If you become pregnant while taking buspirone, call your doctor. (medlineplus.gov)
Increases1
  • Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear. (psychlinks.ca)
SUPPLEMENTS1
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Effects1
  • As we mentioned above, some sleep aids can cause drowsiness, which may intensify the sedative effects of buspirone. (drsprays.com)