Buserelin: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.Fertility Agents, Female: Compounds which increase the capacity to conceive in females.Gonadotropin-Releasing Hormone: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.Menotropins: Extracts of urine from menopausal women that contain high concentrations of pituitary gonadotropins, FOLLICLE STIMULATING HORMONE and LUTEINIZING HORMONE. Menotropins are used to treat infertility. The FSH:LH ratio and degree of purity vary in different preparations.Ovulation Induction: Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.Receptors, LHRH: Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors.Cloprostenol: A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.Fertilization in Vitro: An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.Nafarelin: A potent synthetic agonist of GONADOTROPIN-RELEASING HORMONE with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central PRECOCIOUS PUBERTY and ENDOMETRIOSIS.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Embryo Transfer: The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.Clomiphene: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Ovarian Follicle: An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Hormone Antagonists: Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.Pregnancy Rate: The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.Estrus Synchronization: Occurrence or induction of ESTRUS in all of the females in a group at the same time, applies only to non-primate mammals with ESTROUS CYCLE.Luteal Phase: The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.Postpartum Period: In females, the period that is shortly after giving birth (PARTURITION).Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Corpus Luteum: The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.Ovulation: The discharge of an OVUM from a rupturing follicle in the OVARY.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Administration, Intranasal: Delivery of medications through the nasal mucosa.Urofollitropin: A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).Reproductive Techniques, Assisted: Clinical and laboratory techniques used to enhance fertility in humans and animals.Infertility: Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.Physician-Patient Relations: The interactions between physician and patient.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.United StatesPrescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Urine Specimen Collection: Methods or procedures used to obtain samples of URINE.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.Anesthesia, Dental: A range of methods used to reduce pain and anxiety during dental procedures.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.

A comparison of three gonadotrophin-releasing hormone analogues in an in-vitro fertilization programme: a prospective randomized study. (1/216)

The use of gonadotrophin-releasing hormone analogues (GnRHa) has resulted in improved pregnancy rates in in-vitro fertilization (IVF) treatment cycles. Traditionally, short-acting analogues have been employed because of concerns over long-acting depot preparations causing profound suppression and luteal phase defects adversely affecting pregnancy and miscarriage rates. We randomized 60 IVF patients to receive a short-acting GnRHa, nafarelin or buserelin, or to receive a depot formulation, leuprorelin, all commenced in the early follicular phase and compared their effects on hormonal suppression and clinical outcome. We found that on day 15 of administration there was a significant difference in the suppression of oestradiol from initial concentrations, when patients on buserelin were compared with patients on nafarelin or leuprorelin (54 versus 72 and 65%; P < 0.05) and also in the number of patients satisfactorily suppressed, (80 versus 90 and 90%; P < 0.05), though there were no differences between the analogues by day 21. Similarly there was no difference in hormonal suppression during the stimulation phase or in implantation, pregnancy or miscarriage rates in comparing the three agonists. We conclude that with nafarelin and leuprorelin, stimulation with gonadotrophins may begin after 2 weeks of suppression and that long-acting GnRHa are as effective as short-acting analogues with no detrimental effects on the luteal phase.  (+info)

The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. (2/216)

OBJECTIVES: To assess the effect of short-term (2-3 weeks) pituitary suppression and controlled ovarian stimulation on ovarian and uterine artery Doppler measurements during the in vitro fertilization (IVF) treatment cycle and to compare the pattern of these changes between conception and non-conception cycles as well as between patients with normal and those with polycystic ovaries. DESIGN: Prospective observational study of women undergoing IVF treatment. SUBJECTS: Women using the long-treatment buserelin protocol who did not have uterine fibroids, ovarian cysts or endometrioma. METHODS: Serial transvaginal color and pulsed Doppler measurements of ovarian stromal and uterine artery blood flow velocity were carried out in the early follicular phase of the menstrual cycle, on the day of pituitary suppression and on the day of administration of human chorionic gonadotropin (hCG). The main outcome measures were the ovarian stromal and uterine artery blood flow peak systolic velocity (PSV) and pulsatility index (PI). RESULTS: A total of 105 patients were recruited but six patients were excluded from the analysis because they had only one stage of the measurements performed. There was a significant decline in mean ovarian stromal artery PSV after 2-3 weeks of gonadotropin releasing hormone (GnRH) agonist therapy but no effect on ovarian stromal artery PI. The mean uterine artery PSV or PI did not change significantly after 2-3 weeks of GnRH agonist therapy. There was a significantly higher mean ovarian stromal artery PSV in conception cycles compared to non-conception cycles in the early follicular phase and on the day of pituitary suppression, but not on the day of hCG administration. There were no differences between conception and non-conception cycles in the mean uterine artery PSV or PI. Women with polycystic ovaries had a higher mean ovarian artery PSV on all the three occasions of measurement. CONCLUSION: These data suggest that assessment of ovarian blood flow before commencement of gonadotropin stimulation may play a role in assessing cycles likely to result in pregnancy.  (+info)

Is there a difference in the function of granulosa-luteal cells in patients undergoing in-vitro fertilization either with gonadotrophin-releasing hormone agonist or gonadotrophin-releasing hormone antagonist? (3/216)

Gonadotrophin-releasing hormone (GnRH) regulates gonadotrophin release. It has been shown that GnRH may have a direct effect on the ovary, as the addition of GnRH to granulosa cell cultures inhibits the production of progesterone and oestradiol. Specific GnRH receptors have been found to be present in rat and human granulosa cells. Desensitization of the pituitary by GnRH agonist has become common in in-vitro fertilization (IVF) treatment, usually by a long protocol of 2-3 weeks. With the introduction of GnRH antagonists, which produce an immediate blockage of the GnRH receptors, a much shorter exposure is needed of 3-6 days. The aim of this study was to evaluate the effect of a GnRH agonist (buserelin) and a GnRH antagonist (cetrorelix) on the function of granulosa cells cultured in vitro from IVF patients. Women were treated by IVF randomized either to have buserelin nasal spray from the luteal phase in the previous cycle or cetrorelix from day 6 of the cycle. Both groups had ovarian stimulation with human menopausal gonadotrophin (HMG) 150 IU daily, i.e. HCG was administered when the follicles were larger than 17 mm, and aspirated 36 h later. Granulosa cells, separated and washed from large follicles containing ova, were pooled. After 48 h of pre-incubation, the granulosa cells were cultured for 4 days in medium with either added testosterone or cAMP with or without HCG, with change of medium after 2 days. The progesterone and oestradiol concentrations in the culture medium were measured by immunological assay, and cellular protein was measured by microprotein assay. The results showed that granulosa cells from women treated with GnRH antagonist (cetrorelix) responded earlier to the in-vitro hormone stimulation in terms of progesterone accumulation than women treated with the GnRH agonist (buserelin). This may have been due to difference in time of exposure to the analogue. The results may indicate that the luteal function is less impaired in GnRH antagonist treatment than in GnRH agonist treatment.  (+info)

A prospective, randomized, double-blind clinical trial to study the efficacy and efficiency of a fixed dose of recombinant follicle stimulating hormone (Puregon) in women undergoing ovarian stimulation. (4/216)

A prospective, randomized, double-blind, multicentre (n = 5) study was conducted to compare the influence of either a 100 or 200 IU daily fixed-dose regimen of recombinant follicle stimulating hormone (FSH) on the number of oocytes retrieved and the total dose used in down-regulated women undergoing ovarian stimulation. Fertilization was done by intracytoplasmic sperm injection or conventional in-vitro fertilization. A total of 199 women were treated with FSH, 101 subjects with 100 IU and 98 subjects with 200 IU. In subjects of the 200 IU treatment group, significantly more oocytes were retrieved compared to the 100 IU group (10.6 versus 6.2 oocytes, P < 0.001). The total dose needed to develop at least three follicles with a diameter of > or = 17 mm was significantly lower in the 100 IU treatment group (1114 IU versus 1931 IU, P < 0.001). In the low-dose group, significantly lower serum concentrations of oestradiol, progesterone and FSH were observed at the day of human chorionic gonadotrophin administration. Although more cycle cancellations due to low response were seen in the 100 IU group (n = 24 versus n = 3), the clinical pregnancy rate per started cycle was similar (24.7% in the 100 IU group versus 23.3% in the 200 IU group). In the high-dose group, more side-effects, in particular more cases of ovarian hyperstimulation syndrome, were noted. It is concluded that compared to 200 IU, the use of a 100 IU fixed dose is less efficacious in terms of the number of oocytes retrieved, but more efficient as indicated by a lower total dose.  (+info)

Prevention of premenstrual exacerbation of hereditary coproporphyria by gonadotropin-releasing hormone analogue. (5/216)

A 20-year-old Japanese female needed frequent hospitalization due to premenstrual exacerbation of hereditary coproporphyria (HCP). Intranasal buserelin acetate, a gonadotropin-releasing hormone analogue, was given to suppress her menstrual cycles. Her porphyric symptoms subsided dramatically as she became amenorrhoeic. Urinary excretion of porphyrin derivatives fell significantly. She has been free from recurrent attacks, but suffers a minor porphyric attack once in 5 years. However, borderline osteopenia secondary to hypoestrogenism has been noted. Although these analogues are potent in suppressing estrogen-induced porphyric symptoms, due precautions should be taken to avoid bone demineralization in the long-term use.  (+info)

Persistent dominant follicle alters pattern of oviductal secretory proteins from cows at estrus. (6/216)

The experimental objective was to compare synthesis of oviductal secretory proteins of dairy cows bearing a persistent dominant follicle (PDF) versus a fresh dominant follicle (FDF) at estrus. On Day 7 after synchronized estrus (Day 0), cows received an intravaginal progesterone device and injection of prostaglandin F2alpha (PGF2alpha). On Day 9, cows received an injection of a GnRH agonist (FDF group; n = 3) or received no injection (PDF group, n = 3). On Day 16, all cows received PGF2alpha, and progesterone devices were removed. At slaughter on Day 18 or Day 19, oviducts ipsilateral and contralateral to the dominant follicle were divided into infundibulum, ampulla, and isthmus regions. Explants from oviductal regions were cultured in minimal essential medium supplemented with [3H]leucine for 24 h. Two-dimensional fluorographs of proteins in conditioned media were analyzed by densitometry. Rate of incorporation of [3H]leucine into macromolecules was greater in the infundibulum, ampulla, and isthmus of FDF cows (p < 0.01). Overall, intensities of radiolabeled secretory protein (P) 2 and P13 were greater for FDF than for PDF. In the ampulla, P14 was more intense for FDF while P7 was more intense for PDF. Abundance of P1 in the isthmus was greater for PDF cows. Across regions, P5, P6, P8, P9, and P11 were more intense for PDF than for FDF in the ipsilateral side. In the contralateral side, P19 was more intense for PDF than for FDF, whereas P6, P8, P9, and P11 were more intense for FDF. Differences in biosynthetic activity and in secreted oviductal proteins from cows bearing a PDF may contribute to the decrease in fertility associated with a PDF.  (+info)

The effect of smoking on oocyte quality and hormonal parameters of patients undergoing in vitro fertilization-embryo transfer. (7/216)

PURPOSE: The aim of the present study was to investigate the influence of smoking on different parameters such as oocyte count, embryo score, and basal hormone values within the scope of in vitro fertilization-embryo transfer (IVF-ET). METHODS: Eight hundred thirty-four women undergoing IVF-ET treatment were classified as smokers or nonsmokers on the basis of questionnaires. Additionally, we divided them into three groups according to their stimulation protocol--"combined stimulation" [I; clomiphene citrate plus human menopausal gonadotropin (hMG)], "ultrashort" [II; gonadotropin releasing hormone agonist (GnRHa) plus hMG or follicle-stimulating hormone (FSH)], and "long downregulation protocol" (III)--and further classified again as smokers or nonsmokers within the groups. RESULTS: In general, smoking patients were significantly (P = 0.0195) younger than nonsmokers and showed a significantly (P = 0.0379) lower embryo score and a tendency (P = 0.0931) to produce fewer oocytes. There was no significant difference concerning the number of normally or pathologically fertilized and transferred oocytes and embryos suitable for cryopreservation. Women who smoked had significantly (P = 0.0112) higher basal 17-beta-estradiol (E2), luteinizing hormone (LH) (P = 0.0001), and dehydroepian-drosteronesulfate (DHEAS) (P = 0.0039) levels, but their basal human prolactin (HPRL) levels were significantly (P = 0.0033) lower than those of nonsmokers. According to the stimulation protocol used, we found the following results. Smoking patients in group I showed a significantly (P = 0.023) lower embryo score and produced fewer oocytes (P = 0.0113), with fewer of them being fertilized (P = 0.0072) and transferred (P = 0.0067). Women who smoked had significantly (P = 0.0002) higher basal LH levels, but their HPRL levels were significantly (P = 0.031) lower than those of nonsmokers. Furthermore, they had a thinner endometrium on the day of embryo transfer (P = 0.0366). In group II we measured significantly elevated basal E2 levels (P = 0.0089) and higher LH values (P = 0.0092) in smokers. Group III showed a trend (P = 0.0565) toward lower HPRL values in smokers. CONCLUSIONS: Although the fertilization rate of oocytes and the pregnancy rate were not significantly different between smokers and nonsmokers, we found significantly alterated hormonal parameters and negatively influenced oocyte parameters, particularly after clomiphene stimulation. So we might consider using only GnRHa protocols for smoking patients. Additionally, we advise our patients to stop smoking before an IVF-ET treatment because of the complex effects of smoking on the reproductive and hormonal system.  (+info)

Involvement of parathyroid hormone-related peptide in cell proliferation activity of human uterine leiomyomas. (8/216)

Uterine leiomyomas develop from uterine smooth muscle cells, which are known to be regulated by estrogen and other growth factors. The purpose of this study was to investigate the role of expression of parathyroid hormone related-peptide (PTHrP) in the growth of uterine leiomyomas treated or untreated with gonadotropin-releasing hormone agonist (GnRH-a). Thirty-nine leiomyoma tissues were obtained from 36 patients who had been treated with GnRH-a (n=10) or without GnRH-a (n=29). The intensity of PTHrP immunostaining was categorized into three grades; "negative", "weakly positive", and "positive". Leiomyoma cell growth was estimated by the proliferating cell nuclear antigen (PCNA) labeling index (LI) with an image analyser. We also investigated the correlation between PTHrP expression and cell proliferation or histopathological findings. In the GnRH-a-untreated group, LI of the PTHrP "positive" group was significantly higher than that of the PTHrP "negative" group, but the intensity of PTHrP immunostaining did not correlate with LI in the GnRH-a-treated group. PTHrP expression did not correlate with histological findings or clinical parameters (age and phase of menstrual cycle) in either the GnRH-a-treated or the -untreated group. In addition, the expression of mRNA for PTHrP and its receptor was detected in leiomyomas by reverse transcriptase-polymerase chain reaction (RT-PCR). Our results indicate that the expression of PTHrP in leiomyomas correlated positively with cell growth in the GnRH-a-untreated group, suggesting that PTHrP may act as a local cell growth modifier in an autocrine/paracrine fashion on uterine leiomyomas.  (+info)

Buserelin is a synthetic form of a hormone which occurs naturally in your body. Buserelin for women is used as part of fertility treatment.
Does any one out there know if you have to reduce the dose of buserelin nasal spray once you have achieved down regulation? Im using suprecur at a dose of 150mg ( one puff) four times a day. Im about to start menopur injections, and my clinic is unsure whether the dose needs to be reduced. They normally use buserelin injections, and they do reduce these to a maintanance dose, but they have no experience with the spray. Any info gratefully recieved. Good luck to every one! Ollies ...
bew-sĕ-rel-in). a gonadorelin analogue that is administered as a nasal spray or by subcutaneous injection for the treatment of endometriosis and to help in the management of advanced prostate cancer. Trade names:. Suprecur,. Suprefact. ...
Serum concentrations of luteinising hormone and testosterone were measured by radioimmunoassay one, two, four, seven, and 24 hours after the subcutaneous administration of 500 micrograms of the luteinising hormone releasing hormone agonist [D-Trp6, des-Gly-NH2(10)] LHRH ethylamide or [D-Ser(TBU)6, des-Gly-NH2(10)]LHRH ethylamide in patients who had previously received daily treatment with these peptides for 0, 1, 6, 12, 18, and 24 months. No increase in the serum concentrations of luteinising hormone or testosterone were detected at any time between one and 24 months treatment. The data show that daily subcutaneous administration of the two luteinising hormone releasing hormone agonists used at the appropriate dose can maintain concentrations of serum androgens equivalent to those after castration during long term treatment. ...
BioAssay record AID 74411 submitted by ChEMBL: Inhibitory concentration against binding of [125I]buserelin to human Gonadotropin-releasing hormone receptor.
Twenty four Deoni repeat breeder cows were randomly allocated into 4 groups of six each. The animals of groups I, II and III were injected with 250 g of buserelin acetate (Receptal ) on two occasions i.e. once on day of estrus and second dose on days 10 or 12 or14 respectively in I, II and III groups following breeding, while the animals of group IV served as control. Among the physical characters of estrual cervico-vaginal mucous, typical arborization pattern (80.95 % in pregnant vs. 55.56 % in non-pregnant cows) and marginally high spinnbarkeit readings (24.67+2.7cms in pregnant and 22.21+1.32 cms in non-pregnant cows) favored better fertility, although the differences between the groups were statistically insignificant. However, the pH of estrual cervico-vaginal mucous did not indicate any effect on fertility and it ranged between 8.00 to 9.00. The cows of treatment groups I, II and III registered a considerably higher conception rate of 83.33 percent each, while in control group cows had ...
Zoladex - Get up-to-date information on Zoladex side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Zoladex
TY - JOUR. T1 - [D-LEU6DES-GLY-NH210, pro-ethylamide9]-gonadotropin releasing hormone (leuprolide). T2 - a medical castration for the treatment of prostatic carcinoma. AU - Warner, B. A.. AU - Santen, R. J.. AU - Demers, L. M.. AU - Max, D. T.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=0019723220&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019723220&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019723220. VL - 29. SP - 666A. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 3. ER - ...
Goserelin acetate (Zoladex, AstraZeneca ) is an injectable gonadotropin releasing hormone superagonist ( GnRH agonist ), also known as a luteinizing hormone releasing hormone (LHRH) agonist ....
Zoladex Injection is also used as palliative treatment in advanced prostate cancer. We are leading Zoladex Injection distributors, dealers & suppliers in Mumbai.
Hi all.,br,Ive been injecting Buserelin over the past 8 weeks so totally understand where youre coming from. Dont panic, apparently Im very rare as my system wasnt absorbing the drug properly but its finally worked so now Im onto yet another injection. My clinic has given me the injection "gun" which really helps, in fact Im not sure I would be brave enough without it. If your not using that maybe you could ask for one. I find its also better to do it yourself because its a bit like plucking your eyebrows, it twinges a bit if you do it yourself but hurts like hell when someone else does it !! I think its the surprise element. If your DH wants to be involved, ask him to have a cup of tea waiting for you when youve done.,br,My GP also told me to rub the spot really well after youve injected to get the stuff moving around in your system straight away.,br,Not much help but just to let you know that youre not alone,br,Good Luck,br,Terri,br,x,br ...
The pharmacology of clear clinical development of the other drugs whose hb showed that the peroxisome-proliferating activator complex. At physiological reflex tachycardia, but is by hyperbilirubinaemia. Prothrombin time of a bever- age, other risk of cartilage and a high, www. :plasma showed that cleaves the precise identification of uVA. Is, and, he was no evidence of furosemide inhibit cellular immune cells in susceptibility. They are worn during most devastating loss is approximately 500 somatostatin analogues. Physiotherapy is usually shows a thor- ough search what is the normal dose for atenolol for the british showed that he attends his antibiotics. The comparative pharmacology of the same time or synergistic in the mucosa. 5g/day of administra- tion to check that are eliminated in preventing venous blood pressure. National poisons or available, pruritus, buserelin and myocytes instead. It is used to form of toxic haemin to the bacterial susceptibility/resistance. Thrombosis occurs when ...
Crinone: 90 units. Heparin: 14 vials. Estrofem: 168 tablets. Buserelin: 4 vials. Prednisone: 175 tablets. Gestone PIO: 30 vials Im already taking folic acid, prenatal vitamin, aspirin, calcium, etc, etc, etc…. The pharmacist was fantastic. She stayed in weekly contact during the months of trying to put my order together (apparently there was a Gestone PIO shortage in Ireland), and since I was buying everything at once and dont have insurance coverage, she gave me a 10% discount. When youre spending several thousand dollars, every bit helps. Thank you, C!. Last week I had my first appointment (ultrasound, check meds, hand over a small fortune). The clinic has moved to a new location which is phenomenal because its A. closer to my house and B. has a big parking lot!. The new clinic is absolutely gorgeous and it was strange to see so many familiar faces, though I saw several new faces in the nursing department. I waited and hoped that I would be working with someone Id worked with in the ...
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I have put on 5 pounds and am looking 7 months pregnant! This has made me realise that when I was on oestrogen and mirena I was always bloated too. Qlaira pill (and other combination pills and mini pill) gave me terrible joint/muscle pains but the bloating cleared up. Oestrogen seems to get rid of the joint pain and mood issues but makes me bloat up terribly. I think its partly the jab but it gets worse as the day goes on after I have used the gel ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Zoladex market provides detailed market segment level data on the international market. The Zoladex market report addresses forecast and growth patterns by company, regions and type or application from 2016 to 2021.. Browse detailed information about Zoladex Market Research [email protected] http://www.360marketupdates.com/10361602. In this introductory section, the Zoladex market research report incorporates analysis of definitions, classifications, applications and industry chain structure. Besides this, the report also consists of development trends, competitive landscape analysis, and key regions development status.. The report starts with a basic Zoladex market overview. It also acts as a vital tool to industries active across the value chain and for new entrants by enabling them to take advantage of the opportunities and develop business strategies.. Get a Sample PDF of Zoladex Market Research [email protected] ...
This page includes the following topics and synonyms: Gonadotropin-releasing Hormone Agonist, GnRH agonist, Nafarelin Acetate, Synarel.
Demeestere, Isabelle ; Brice, Pauline ; Peccatori, Fedro A ; Kentos, Alain ; Dupuis, Jehan ; et. al. No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial.. In: Journal of Clinical Oncology, Vol. 34, no.22, p. 2568-2574 (2016 ...
Trade Name: Zoladex®. For which conditions is this drug approved? Goserelin is FDA approved for the treatment of advanced prostate cancer or for the treatment of prostate cancer that has not spread to distant sites (stages B2-C) in combination with the hormone agent flutamide. It is also approved for the treatment of advanced breast cancer in pre and peri-menopausal women. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Goserelin is classified as a luteinizing hormone releasing hormone (LHRH) agonist. LHRH is a naturally occurring hormone in the body that is involved in stimulating the production of female and male hormones such as estrogen and testosterone. Goserelin inhibits ...
Question - Is a delay in Zoladex past its due date okay? Affect efficacy of radiotherapy? Have prostate cancer.. Ask a Doctor about diagnosis, treatment and medication for Prostate cancer, Ask an Oncologist
Hi Ladies, About a year ago now I was on Zoladex (with add-back HRT) for stage 4 Endo but had to come off it as it made me quite poorly. Then I was on Depo-Provera injections for a few months but...
Hi Ladies, i had a years worth of Zoladex to treat Endo the course ended on the 30th august but here we are on the first of November and i still havent had a period still get hot flushes and all...
CD8+ T cell responses are thought to play an important role during HIV infection, particularly in HIV controllers (HIC) in whom viral replication is spontaneously controlled without any treatment. of HIV-specific CD8+ T cells were observed only in a subset of HLA-B*57+ subjects. They were tightly associated with the ability to suppress viral replication to kill virally infected autologous CD4+ T cells and therefore suppress viral replication (15, 16). However, this CD8+ T cell viral suppression activity is not present in all HIC (17). Most studies have been performed with HLA-B*57+ or HLA-B*27+ patients, since they represent a large. ...
Although epidemiologic evidence for the ability of combined oral contraception (OC) to reduce the risk of ovarian cancer (OvCa) is convincing, the biological mechanisms underlying this effect are largely unknown. We conducted the present study to determine if OC also influences ovarian carcinogenesis in a genetic mouse model and, if so, to investigate the mechanism underlying the protective effect. LSL-K-rasG12D/+PtenloxP/loxP mice were treated with ethinyl estradiol plus norethindrone, contraceptive hormones commonly used in combined OC, or norethindrone alone, or a gonadotropin-releasing hormone agonist. The combined OC had a 29% reduction in mean total tumor weight compared with placebo (epithelial tumor weight, −80%). Norethindrone alone reduced mean total tumor weight by 42% (epithelial tumor weight, −46%), and the gonadotropin-releasing hormone agonist increased mean total tumor weight by 71% (epithelial tumor weight, +150%). Large variations in tumor size affected the P values for ...
All patients in the initial cohort were treated with long protocol for ovarian stimulation. For pituitary down-regulation, patients were treated with daily administration of 0.5 mg buserelin (suprefact, Aventis, Frankfurt, Germany) from day 21 of menstrual cycle. Buserelin was reduced to 0.25 mg daily when ovaries were quiescent on ultrasound, and COH was initiated with recombinant FSH (Gonal F, Serono, Aubnne, Switzerland) 150 IU/day on day 2 of withdrawal bleeding. Serial ultrasound examinations and evaluation of serum E2 levels were used to assess ovarian response, and then gonadotropin dose adjustments were done as required. Human chorionic gonadotropin (pregnyl, Organon, Oss, the Netherlands ) 10,000 IU was administered when at least two follicles reached a mean diameter of 18 mm.. Oocyte retrieval was performed 34-36 hours after hCG administration and conventional insemination or ICSI was performed as clinically appropriate.. In 187 patients allocated to fresh ET group, ET were performed ...
IR Zoladex 10.8mg updates. Section 4.3 First paragraph, addition of the word severe after the first word Known, section now reads,. "Known severe hypersensitivity to the active substance or to any of the excipients of this product.. Pregnancy and lactation (see section 4.6).". Section 4.4 Re-wording in first paragraph, now reads,. "Zoladex LA is not indicated for use in children, as safety and efficacy have not been established in this patient group.". Re-wording in sub paragraph Males, now reads,. "Males. The use of Zoladex LA in men at particular risk of developing ureteric obstruction or spinal cord compression should be considered carefully and the patients monitored closely during the first month of therapy. If spinal cord compression or renal impairment due to ureteric obstruction are present or develop, specific standard treatment of these complications should be instituted. Consideration should be given to the initial use of an anti-androgen (e.g. cyproterone acetate 300 mg daily for ...
PBRT and short-term androgen deprivation [STAD]): Beginning 2 months before the start of PBRT, patients undergo STAD, using a combination of antiandrogen (AA) and LHRH agonist therapy, for a total of 4-6 months. Patients receive AA therapy comprising either oral flutamide 3 times daily or oral bicalutamide once daily for at least 4 months. Patients receive LHRH agonist injection beginning concurrently with or 2 weeks after the start of AA therapy. LHRH agonist injection consists of analogs approved by the FDA (or by Health Canada for Canadian institutions) (e.g., leuprolide, goserelin, buserelin, or triptorelin) and may be given in any possible combination (may be given as a single 4-month injection and one to two 1-month injection[s], two 3-month injections, or a 6-month injection), such that the total LHRH agonist treatment time is 4-6 months. Approximately 2 months after beginning of STAD, patients undergo PBRT as in arm I ...
Quarante et un essais (n = 4935 femmes) ont été inclus. Les données suggèrent que les analogues de la GnRH ont été plus efficaces pour le soulagement des symptômes que labsence de traitement/un placebo. Aucune différence statistiquement significative na été rapportée entre les analogues de la GnRH et le danazol pour la dysménorrhée RR = 0,98 (IC à 95 % de 0,92 à 1,04 ; P = 0,53). En dautres termes, cela correspond à 3 femmes pour 1000 de moins (IC à 95 % de 12 à 6) qui présentent un soulagement de la douleur symptomatique dans le groupe traité par analogue de la GnRH. Les événements indésirables signalés se sont avérés plus nombreux dans le groupe traité par analogue de la GnRH. Pour la résolution globale, il a été observé un effet bénéfique en faveur des analogues de la GnRH, RR = 1,10 (IC à 95 % de 1,01 à 1,21 ; P = 0,03) comparativement au danazol. Aucune différence statistiquement significative na été observée en termes de douleur globale entre les ...
Gonadotropin-releasing hormone (GnRH) is considered to stimulate LH secretion from the pituitary. This antibody is raised against an GnRH analog (GnRHa).
ProSpecs Peptide Hormones include: ACTH, Antide, Argipressin, Atosiban, Buserelin, Cetrorelix, DDAVP, Deslorelin, Elcatonin, Exenatide, Exendin-4, Ganirelix, GHRL, GHRP-2, GHRP-6, Goserelin, Hexarelin, Histrelin, Lanreotide, Lypressin, MT-II, NAF, PMSG, Secretin, Sincalide, Pramlintide, Somatostatin, Terlipressin, Triptorelin Acetate, Thymopentin, Thymosin- α1, Thymosin β4, Vasopressin
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Hormone therapy involves trying to stop your body from producing the male sex hormones testosterone, which can stimulate the growth of cancer cells. This type of therapy can also block hormones from getting into cancer cells. Sometimes doctors use a combination of drugs to achieve both. In most men with advanced prostate cancer, this form of treatment is effective in helping both shrink the cancer and slow the growth of tumors. Sometimes doctors use hormone therapy in early-stage cancers to shrink large tumors so that surgery or radiation can remove or destroy them more easily. In some cases, hormone therapy is used in combination with radiation therapy or surgery. After these treatments, the drugs can slow the growth of any stray cancer cells left behind. Some drugs used in hormone therapy decrease your bodys production of testosterone. The hormones - known as luteinizing hormone-releasing hormone (LH-RH) agonists - can set up a chemical blockade. This blockade prevents the testicles from ...
Hormone therapy involves trying to stop your body from producing the male sex hormones testosterone, which can stimulate the growth of cancer cells. This type of therapy can also block hormones from getting into cancer cells. Sometimes doctors use a combination of drugs to achieve both. In most men with advanced prostate cancer, this form of treatment is effective in helping both shrink the cancer and slow the growth of tumors. Sometimes doctors use hormone therapy in early-stage cancers to shrink large tumors so that surgery or radiation can remove or destroy them more easily. In some cases, hormone therapy is used in combination with radiation therapy or surgery. After these treatments, the drugs can slow the growth of any stray cancer cells left behind. Some drugs used in hormone therapy decrease your bodys production of testosterone. The hormones - known as luteinizing hormone-releasing hormone (LH-RH) agonists - can set up a chemical blockade. This blockade prevents the testicles from ...
Sigma-Aldrich offers Sigma-L2761, [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Gonadotropin-releasing hormone agonist (GnRHa) therapy is associated with increased risks of numerous clinically relevant adverse events compared with orchiectomy.
Complementar Deoxyribonucleic Acid Cloning, Gene Expression, and Ligand Selectivity of a Novel Gonadotropin-Releasing Hormone Receptor Expressed in the Pituitary and Midbrain of ,I,Xenopus Laevis,/I ...
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TY - JOUR. T1 - Modulation of pituitary luteinizing hormone releasing hormone receptors by sex steroids and luteinizing hormone releasing hormone in the rat. AU - Marchetti, B.. AU - Reeves, J. J.. AU - Pelletier, G.. AU - Labrie, F.. PY - 1982. Y1 - 1982. N2 - The effect of sex steroids on pituitary luteinizing hormone releasing hormone (LHRH) receptor number and affinity was studied in adult castrated male and female rats treated for 2 weeks with 17β-estradiol (E2), testosterone (T), 5α-dihydrotestosterone (DHT) or progesterone (P) alone or in combination. The effect of chronic treatment with the potent LHRH agonist [D-Ser(TBU)6, des-Gly-NH210] LHRH ethylamide, Buserelin, was studied in intact and castrated animals. [125I]-Buserelin was used as tracer to measure LHRH receptors in individual pituitaries. Daily treatment of intact male rats for 2 weeks with Buserelin (200 ng) increased pituitary LHRH receptor concentration while the same treatment in castrated animals reversed by 60% the ...
Many women diagnosed with breast cancer, especially younger women, are concerned about their ability to have children after treatment. Some breast cancer treatments can cause temporary infertility or make it harder to get pregnant after treatment ends. Other treatments, especially certain chemotherapy regimens, can cause early menopause and infertility. A meta-analysis suggests that women diagnosed with breast cancer who are treated with a luteinizing hormone-releasing hormone agonist in addition to chemotherapy may be more likely to become pregnant after chemotherapy ends. The research was presented on Sept. 28, 2015 at the 2015 European Cancer Congress and published online on Sept. 7, 2015 by the Annals of Oncology. Read the abstract of "Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies." Luteinizing hormone-releasing hormone agonists are ...
The ability of prolactin to influence the responsiveness of the lactating rat pituitary to luteinising hormone releasing hormone has been examinedin vitro. The pituitary responsivenessin vivo to luteinising hormone releasing hormone decreased as a function of increase in the lactational stimulus. Prolactin inhibited the spontaneousin vitro release of luteinising hormone and follicle stimulating hormone to a small extent, from the pituitary of lactating rats with the suckling stimulus. However, it significantly inhibited the release of these two hormones from luteinising hormone releasing hormone-stimulated pituitaries. The responsiveness of pituitaries of rats deprived of their litter 24 h earlier, to luteinising hormone releasing hormone was also inhibited by prolactin, although minimal. It was concluded that prolactin could be influencing the functioning of the pituitary of the lactating rat by (a) partially suppressing the spontaneous release of gonadotropin and (b) inhibiting the ...
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William R. Berry, MD, discusses luteinizing hormone-releasing hormone agonists versus antagonists as treatment options for patients and highlights the novel techniques for prostate cancer imaging.
For the long protocol of down regulation in in vitro fertilization (IVF) cycles, are depot and daily gonadotropin-releasing hormone agonists (GnRHa) equally effective?
This additional drug may be a GnRH agonist eg, Zoladex, progestin eg, norethindrone acetate or a birth control pill eg, Alesse. Currently, some
Development and utility of in vitro release methods to characterize in vivo performance of depot formulations for the subcutaneous and intra-articular route of administration ...
Indications: When a woman is about to ovulate, her body releases a large amount of a hormone called LH (Luteinising Hormone). LH is always present in your urine but the levels increase (surge) in the middle of your cycle, causing you to release an ...
Although both laparoscopic ablation and gonadotropin-releasing hormone analogs (GnRHa) are treatments for endometriosis, there are no studies that directly compare these two treatment options. METHODS: This study compares the use of GnRHa therapy and laparoscopic ablation concerning symptom relief, recurrence of symptoms, safety, side effects of treatment and improvement of quality of life in women ages 18-50 with diagnosed endometriosis. The study design is an evidence-based literature review, assessing each study for its research design, inclusion and exclusion criteria, treatment results, adverse affects and conclusions. RESULTS: All but one research study showed that GnRHa are effective at improving quality of life by relieving endometriosis symptoms up to one year post treatment. Side effects were consistent with hypoestrogenemia and were non-life threatening. Laparoscopic ablation was found to successfully treat endometriosis symptoms, but fertility rates were not consistently improved. ...
Apalutamide with or without Abiraterone Acetate, Gonadotropin-Releasing Hormone Analog, and Prednisone in Treating Patients with High-Risk Prostate Cancer Undergoing Surgery
A group of 97 spring-calving beef cows were initially oestrus synchronised with controlled internal drug release (CIDR) intravaginal progesterone implants inserted for nine days and a prostaglandin injection on day 7. Approximately half the cows were given 10 μg buserelin when the implants were inserted, and they all received a single fixed-time artificial insemination (Al) 56 hours after the withdrawal of the implants. The overall pregnancy rate to the first synchronised Al was 55 per cent, the buserelin-treated cows having a pregnancy rate of 63 per cent compared with 47 per cent in the untreated cows (P,0.05). Sixteen days after the first synchronised Al all the cows were re-implanted with used CIDR implants which were removed five days later, and the cows received a second synchronised Al on days 23 to 24. Cows which received the second Al were implanted with new CIDR devices 16 days later and these were removed after five days and the non-pregnant cows received a third synchronised Al. The ...
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Learn about Zoladex 10.8 mg (Goserelin Acetate Implant) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Considering the existing conflicts about how an elevated body mass index (BMI) affects fertility, this study had the objective of evaluating the impact of overweight and obesity on the results of IVF/ICSI (in-vitro fertilisation/intracytoplasmatic sperm injection) performed at the Human Reproduction Centre of Faculdade de Medicina do ABC. Retrospective data from 208 IVF cycles of 191 women, performed at our laboratory from February through June, 2008, were used to calculate their BMI. On the basis of the results, the patients were divided into two groups: Group 1: BMI ,25 kg/m2 and Group 2: BMI ≥25 kg/m2. Of the 208 cycles, 137 were from patients with BMI ,25 kg/m2 and 71 cycles from patients with BMI ≥25 kg/m2. Patients ages and the number of cycles with gonadotrophin-releasing hormone agonist and antagonist were similar in both groups. The doses of follicle-stimulating hormone used for ovarian induction per cycle, the number of retrieved oocytes, fertilisation rate, embryo quality and ...
Goserelin (INN, USAN, BAN), or goserelin acetate, sold under the brand name Zoladex (by AstraZeneca) among others, is a medication which is used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist. Structurally, it is a decapeptide. It is the natural LHRH/GnRH decapeptide with two substitutions to inhibit rapid degradation. Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production. Zoladex was approved by the U.S. Food and Drug Administration in 1989 for treatment of prostate cancer. Goserelin acetate is used to treat hormone-sensitive cancers of the ...
Wojniusz, Slawomir; Vögele, Claus; Ropstad, Erik; Evans, Neil; Robinson, Jane; Sütterlin, Stefan; Erhard, Hans W.; Solbakk, Anne-Kristin; Endestad, Tor; Olberg, Dag Erlend & Haraldsen, Ira Hebold (2011). Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep. Hormones and Behavior. ISSN 0018-506X. 59, s 22- 27 . doi: 10.1016/j.yhbeh.2010.09.010 Vis sammendrag In mammals, sex specialization is reflected by differences in brain anatomy and function. Measurable differences are documented in reproductive behavior, cognition, and emotion. We hypothesized that gonadotropin-releasing hormone (GnRH) plays a crucial role in controlling the extent of the brains sex specificity and that changes in GnRH action during critical periods of brain development, such as puberty, will result in altered sex-specific behavioral and physiological patterns. We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH ...
Wojniusz, Slawomir; Vögele, Claus; Ropstad, Erik; Evans, Neil; Robinson, Jane; Sütterlin, Stefan; Erhard, Hans W.; Solbakk, Anne-Kristin; Endestad, Tor; Olberg, Dag Erlend & Haraldsen, Ira Hebold (2011). Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep. Hormones and Behavior. ISSN 0018-506X. 59, s 22- 27 . doi: 10.1016/j.yhbeh.2010.09.010 Show summary In mammals, sex specialization is reflected by differences in brain anatomy and function. Measurable differences are documented in reproductive behavior, cognition, and emotion. We hypothesized that gonadotropin-releasing hormone (GnRH) plays a crucial role in controlling the extent of the brains sex specificity and that changes in GnRH action during critical periods of brain development, such as puberty, will result in altered sex-specific behavioral and physiological patterns. We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH ...
There was apparently also some research that says that Zometa helped premenopausal breast cancer patients by making it somewhat less likely that cancer would metastasize to the bone. The reports say by 36%, but it had to do with a study of 1800 patients (I think), in which half got Zometa and half didnt (all were premenopausal, early stage breast cancerpatients). 6% of those on Zometa ended up with bone metastases versus 9% of those who didnt get it. 6% of 900 is 54 patients with Zometa, versus 81 patients without Zometa ...
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The evidence supporting this regimen comes from a review by Loblaw et al. The initial review consisted of 10 randomised controlled trials, six systemic reviews and one Marko model to formulate the guidelines. Bilateral orchidectomy or luteinising hormone releasing hormone agonists (LHRH) are the recommended initial treatments.r An update of these guidelines were published in 2007 with no change in the above standard first-line treatments.r. A meta-analysis of the literature (10 RCTs, 1,908 patients) addressed the relative benefit of LHRH agonists with orchidectomy, diethylstibestrol (DES), or the choice of DES or orchidectomy. No improvement in survival rate, time to progression of disease, or time to treatment failure was observed (which included drug discontinuations indicative of adverse events in the medically managed patients). Two-year hazard ratio for OS was 1.26 (95% CI, 0.91 to 1.39) compared to orchidectomy.r. ...
Gonadotropin-Releasing Hormone-Associated Peptide (Human, 34-56) Antiserum Anti Gonadotropin-Releasing Hormone-Associated Peptide (Human, ...
cancer. His current treatment consists of Estracyt and LHRH agonist. It is recommended to consider Chemotherapy as an another ... brain ictus in 1999 with no consequences; aneurism of the abdominal aorta with a diameter of 30 mm. Case History: February 2002: ... curvature. Adenopathic formations are present in the pelvic area, along the external iliac axes, with a maximum diameter of 26 mm to .... ...
Gonadotropin-releasing hormone antagonists (GnRH antagonists) are a class of medications that antagonize the gonadotropin-releasing hormone receptor (GnRH receptor) and thus the action of gonadotropin-releasing hormone (GnRH). Some are similar in structure to natural GnRH (a hormone made by neurons in the hypothalamus) but that have an antagonistic effect. These GnRH antagonists are peptide molecules that are made up multiple, often synthetically produced amino acids. Others are small-molecule, non-peptide compounds. GnRH antagonists compete with natural GnRH for binding to GnRH receptors, thus decreasing or blocking GnRH action in the body. Testosterone promotes growth of many prostate tumors and therefore reducing circulating testosterone to very low (castration) levels is often the treatment goal in the management of men with advanced prostate cancer. GnRH antagonists are used to provide fast suppression of testosterone without the surge in testosterone levels that is seen when treating ...
Goserelin, a lutenizing hormone-releasing hormone agonist, reduces the long-term risk of disease recurrence and deaths in premenopausal women with early breast cancer who did not take tamoxifen, according to trial data reported in the February 24 online issue of the Journal of the National Cancer Institute. Systematic reviews have shown that lutenizing hormone-releasing hormone agonists, […]. ...
The highly conserved DRY motif located at the end of the third transmembrane of G-protein-coupled receptors has been described as a key motif for several aspects of GPCR functions. However, in the case of the vertebrate gonadotropin-releasing hormone receptor (GnRHR), the amino acid in the third position in the DRY motif is variable. In the lamprey, a most basal vertebrate, the third amino acid of the DRY in lamprey (lGnRHR-1) is His, while it is most often His/Gln in the type II GnRHR. To investigate the functional significance of the substitution of DRY to DRH in the GnRHR-1, second messenger signaling, ligand binding and internalization of the wild-type and mutant lGnRH receptors were characterized with site-directed mutagenesis. Treatment of the DRE151 and DRS151 mutant receptors with lamprey GnRH-I significantly reduced inositol phosphate compared to wild-type (DRH151) and DRY151 receptors. The Log IC50 of wild-type receptor (-9.554 +/- 0.049) was similar to the Log IC50 of DRE151, DRS151 and
Manufacturer : Bayer HealthCare Pharma. Quantity: 1 box (50 tablet). Contents: Cyproterone acetate. Dosage: Men Reduction of drive in sexual deviations Initially 1 tab bid. May increase to 2 tab bid-tid.Inoperable prostatic carcinoma 2 tab bid-tid. Do not interrupt treatment nor reduce dose after improvement or remissions occur.. To reduce initial increase of testosterone in treatment w/ LHRH agonists Initially 2 tab bid for 5-7 days, then 2 tab bid for 3-4 wk w/ an LHRH agonist.. To treat hot flushes in patients under LHRH analogues or who have had orchiectomy 1-3 tab/day w/ upward titration up to 2 tab tid.. Women Severe signs of androgenization 2 tab daily from 1st-10th day of cycle, together w/ progestogen-estrogen-containing prep eg 1 tab Diane-35 daily from 1st-21st day of cycle. ...
Descriptive coverage of pipeline development activities for "Gonadotropin-Releasing Hormone (GnRH) Receptor (LHRH Receptor) Antagonist - Pipeline therapeutics development coverage provides descriptive product profiles including (but not limited to) drug description, product development and R&D activities encompassing clinical and pre-clinical studies, designations, collaborations, licensing deals, grants, technologies and patent details ...
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For patients without health insurance, treatment with drugs typically ranges from $20 a month - $240 per year - up to $6,000 total for a six-month course of treatment with a name-brand drug. My Gp managed to get it put through on the NHS quite fast, so I went from GP appointment to op in 5 months, including 2 monthly Zoladex injections. As always it would be best to talk to fibroids and spicy foods health care provider about looking into using the darker varieties of maca for thyroid health. In general subserous fibroids produce few symptoms unless they get quite large or are located near the bladder.
கருவகவூக்கி வெளியிடு இயக்குநீர் (Gonadotropin-releasing hormone; GnRH) என்பது, எந்த திசுக்களின் மீது செயலாற்றுகிறதோ, அவற்றின் வளர்ச்சியைத் தூண்டக்கூடிய, உயிரணுக்களை மிகைப்பெருக்கம் அல்லது மிகை வளர்ச்சிச் செய்யக்கூடிய தூண்டும் இயக்குநீர் (trophic hormone)[1] வகைகளுள் ஒன்றாகும். இது லூட்டினைசிங் இயக்குநீர்- வெளியிடு இயக்குநீர், லூலிபெரின் என்றும் அழைக்கப்படுகின்றது. முற்பகுதி பிட்யூட்டரியிலிருந்து ...
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Oh, cmon! Youve just got the one! From my GCSE biology, which was shaky enough as it is, I can remember that we girls have at least 5: oestrogen, progesterone, luteinising hormone, follicle stimulating hormone AND testosterone (though obviously not as much of that). And ours go up and down ALL the time - have you seen the graphs?! Yours just goes up. Myyeeeeuuuurrrrggghh ...
Bachem offers H-4644 (D-Ser⁴,D-Trp⁶)-LHRH for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
Professional guide for Cetrorelix. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Purpose: In addition to their expression on pituitary cells, receptors for luteinizing hormone-releasing hormone (LH-RH) are found on most prostate cancer cells. These tumoral LH-RH receptors mediate the direct cytotoxic effects of LH-RH analogs and are potential therapeutic targets. Although pituitary LH-RH receptors are downregulated following prolonged exposure to LH-RH agonists, there is no evidence that tumoral receptors behave in a similar manner. To better characterize expression of tumoral LH-RH receptors, specimens of prostate cancer from various cohorts of patients were analyzed.. Experimental Design: Surgical specimens were obtained from untreated patients with prostate cancer and from patients with metastatic castration-resistant prostate cancer previously treated with bilateral orchiectomy. To address the possibility of receptor downregulation, two additional cohorts of patients who had been previously treated with LH-RH agonists were included. One group received neoadjuvant therapy ...
Aim: Gonadotropin-releasing hormone (GnRH) agonists are used to treat men with prostate cancer (PCa). To date, no study has fully assessed patterns of adherence to GnRH agonists. We investigated patterns of adherence to GnRH agonists using data from Prostate Cancer data Base Sweden (PCBaSe).Methods: PCBaSe links the National Prostate Cancer Register (NPCR) Sweden to other healthcare registers and demographic databases. Men on primary or secondary GnRH agonists between 2006-2013 entered the study 45 days after GnRH agonists initiation (run-in period) and exited at 3 years. Medication possession ratio quantified adherents (≥80%). Multivariable logistic regression models included age, injection interval, PCa risk categories, Charlson Comorbidity Index, prior PCa treatment, civil status and year of GnRH initiation. Odds ratios (OR) and 95% confidence intervals (CI) expressed odds of adherence.Results: Men on primary GnRH agonists (n = 8,105) were more adherent with increasing age (75-84 years ...
BACKGROUND: Prostate cancer (PCa) is often associated with psychopathological symptoms such as anxiety. This study evaluated the effects of the luteinizing hormone-releasing hormone agonist therapy leuprorelin acetate (LA) on anxiety and quality of life (QoL) over time in men with PCa. METHODS: This observational, non interventional, multicenter study was conducted in France. Patients with PCa eligible for therapy with a 6-month LA depot were enrolled. Patients completed questionnaires assessing anxiety (memorial anxiety scale for prostate cancer [MAX-PC] ; state trait anxiety inventory [STAI]) and QoL (medical outcomes study 12-item short-form health survey [SF-12] physical summary component [PCS] and mental component summary [MSCS] subscales) at baseline and 6 months after 6-month LA depot administration ...
You should first clean the area well to avoid trapping bacteria that could cause further problems. A total of 90 women were randomized to receive only TCA or receive a single dose of gonadotropin-releasing hormone analog 1 month before the procedure. Are proved to be pathophysiology symptoms of fibroid uterus in iron and other vital vitamins, which can be included in our daily diets to treat the problem of fibroid tumors. For instance women whose fibroids bleed profusely are often overwhelmed and unable to cope with their workload.
Looking for online definition of Gonadotropin-releasing horomone in the Medical Dictionary? Gonadotropin-releasing horomone explanation free. What is Gonadotropin-releasing horomone? Meaning of Gonadotropin-releasing horomone medical term. What does Gonadotropin-releasing horomone mean?
That it is reasonable for patients with isolated channels for the stapes of the, the figure is reproduced by the reinsertion of the head. 4.7) median nerve care of the disordered group than should the intestine of the. Consider consultation with a linear model of history] hertz n. The utility of these two arrangements occurs at ph above 6. Because of their urine carefully into latrine and to symptoms always come on at least 7 hours, ace inhibitors and gonadotropin-releasing hormone agonists have shown that people display more or less of a platelet count is helpful in these situations. Since the patient until you ve fallen into the cavity. Prop abbrev. Glp-1 is degraded by the which will stimulate awareness of its disorders. Parkinsonism due to affection of white blood cell transfusion should be questioned about symptoms that impede quality of life) improves significantly 11 months bacillary) for 4 weeks. Gene complex n. The study included patients with advanced a-v block. They differ in their ...
The effects of addition of gonadotrophin-releasing hormone (GnRH) to a progesterone plus oestradiol-based protocol and timing of insemination in Holstein cows treated for timed AI (TAI) were evaluated. Cows (n=481) received a progesterone device and 2mg oestradiol benzoate. After 8 days, the device was removed and 25mg dinoprost was administered. Cows were allocated to one of three (Study 1; n=57 ...
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UroToday - GU OncToday brings coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of GU oncology and urology.
Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013. - Mechanism of Action & Protocol.
抗体名称:GNRHR抗体,Anti-GNRHR抗体背景资料:GNRHR,alsonamedasGRHR,belongstotheG-proteincoupledreceptor1family.GNRHRisareceptorforgonadotropinreleasinghormone(GnRH)thatmediatestheactionofGnRHtostimulatethesecretiono
Cystic ovarian disease in cows was treated either with a single intramuscular injection of 500 micrograms cloprostenol, a prostaglandin F2 alpha analogue, in 77 cases of luteal cysts or with 500 micrograms gonadorelin or 20 micrograms buserelin, gonadotrophin releasing hormone or its analogue (GnRH), in 116 cases of follicular cysts. Recovery was defined as the absence of cysts and the formation of a corpus luteum either with or without observed oestrus within 10 days after treatment with cloprostenol and 15 days after treatment with GnRH. Recovery occurred in 65 per cent and 52.6 per cent of cases, respectively, in average times of 4.9 and 19 days. Fifteen days after treatment with GnRH, 20 cows with luteinised cysts were treated with cloprostenol and 15 recovered in a mean of 20.4 days, while 10 which still had follicular cysts, were given GnRH and one recovered 31 days after the beginning of treatment. Another 27 cows, in which cysts became luteinised, were treated with cloprostenol seven ...
Xenopus laevis (X) GnRHRs ( approximately 40%). This distinction is retained at comparable whole cell expression levels, and the hGnRHR PCSE is increased by addition of the XGnRHR C-tail (h.XGnRHR) or by a membrane-permeant pharmacological chaperone (IN3). The IN3 effect is concentration- and time-dependent and IN3 also enhances the hGnRHR-mediated (but not h.XGnRHR- or mouse GnRHR-mediated) stimulation of [(3)H]inositol phosphate accumulation and the hGnRHR-mediated reduction in cell number. We also find that the PCSE for hGnRHRs and h.XGnRHRs is low and is greatly increased by IN3 in two hormone-dependent cancer lines, but is higher and less sensitive to IN3 in a gonadotrope line. Finally, we show that the effect of IN3 on hGnRHR PCSE is not mimicked or blocked by two peptide antagonists although they do increase the PCSE for h.XGnRHRs, revealing that an antagonist-occupied cell surface GnRHR conformation can differ from that of the unoccupied receptor. The low PCSE of hGnRHRs and this novel ...
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Gonadotropin-releasing hormone (GnRH) is a neurohormone central to initiation of the reproductive hormone cascade. Pulsatile secretion of GnRH from the hypothalamus is key in establishing and maintaining normal gonadal function.
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Ganirelix Acetate Organon is a medicine available in a number of countries worldwide. A list of US medications equivalent to Ganirelix Acetate Organon is available on the Drugs.com website.
TY - JOUR. T1 - Sequence analysis of the turkey LH β subunit and its regulation by gonadotrophin-releasing hormone and prolactin in cultured pituitary cells. AU - You, Seungkwon. AU - Foster, L. K.. AU - Silsby, J. L.. AU - El Halawani, M. E.. AU - Foster, D. N.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - cDNAs encoding the precursor molecule of the turkey LH β subunit (tLHβ) were cloned from a turkey pituitary cDNA library. The nucleotide sequence of the longest of two different tLHβ cDNA clones contained 592 bp, and included 23 bp of the 5 untranslated region (UTR) and 92 bp of the 3 UTR in addition to a 477 bp open reading frame that encoded a 39 amino acid leader polypeptide and a 120 amino acid mature apoprotein. Turkey and chicken LHβ sequences shared approximately 92 and 93% nucleotide and amino acid sequence similarities respectively. Northern blot analysis of total cellular anterior pituitary RNA showed that an approximate 800 base transcript hybridized to a 32P-labelled tLHβ cDNA ...
Background: This retrospective study evaluated the effect of profound pituitary suppression with oral contraceptive pill (OCP) pretreatment in gonadotropin-releasing horm..
Review question. The combined oral contraceptive pill (COCP) is commonly used to treat pain associated with endometriosis but how well it works is unclear.. Background. Endometriosis is a common womens healthcare condition where the endometrium (lining of the womb) grows at sites outside the womb, such as the ovaries (which produce eggs). Endometriosis is commonly found in women with painful periods, pain with sexual intercourse, pelvic pain and infertility (difficulty in having a baby). Hormonal treatments, including COCPs and medicines called gonadotrophin-releasing hormone analogues (for example, goserelin) are used to relieve the pain symptoms associated with endometriosis. However, many of the hormonal treatments have side effects which limit their acceptability and duration of use.. Study characteristics. Cochrane authors searched for clinical studies on 19 October 2017. We found five trials, including 612 women, that met the inclusion criteria. The studies took place in Egypt, the US, ...
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1.18 years of age or older 2. Able to provide written informed consent or have their legal representatives provide written informed consent 3. Documented histological or cytological evidence of adenocarcinoma of the prostate. Subjects whose pathology reports are no longer available may be enrolled if, in the opinion of the investigator, the subject has a clinical course consistent with prostatic adenocarcinoma 4. ECOG Performance Status of 0 or 1 5. Undergone orchiectomy, or have ongoing LHRH analogue therapy prior to C1D1. Subjects on LHRH analogues should remain on these agents for the duration of the study 6. Castrate levels of testosterone less than or equal to 50 ng/dl (or 1.7 nmol/L) and have progressive disease at Screening defined as PSA rise determined by a minimum of 2 rising PSA values greater than or equal to 1 week between each assessment. The PSA value at the Screening visit must be greater than or equal 2ng/mL with or without: Soft tissue disease progression defined by RECIST 1.1 ...
gonadotropin-releasing hormone (GnRH): GnRH a neurohormone consisting of 10 amino acids that is produced in the arcuate nuclei of the hypothalamus. GnRH stimulates the synthesis and secretion of the two gonadotropins...
Goserelin is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist. Buy LHRH/GnRH inhibitor Goserelin from AbMole BioScience.
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GnRH agonists that have been marketed and are available for medical use include buserelin, gonadorelin, goserelin, histrelin, ... Agonists with two substitutions include: leuprolide, buserelin, histrelin, goserelin, and deslorelin. The agents nafarelin and ... Buserelin. Suprefact. Breast cancer; Endometrial hyperplasia; Endometriosis; Female infertility (assisted reproduction); ... GnRH agonists routinely used for this purpose are: buserelin, leuprorelin, nafarelin, and triptorelin.[8] ...
Buserelin is a similar GnRH agonist used in humans. Deslorelin is a synthetic analogue of a naturally occurring luteinising- ...
"Endometrial patterns during danazol and buserelin therapy for endometriosis: comparative structural and ultrastructural study ...
... and buserelin. Initially, GnRH agonists increase the production of LH. However, because the constant supply of the medication ...
A newer hormonal intervention used in Europe is the use of GnRH analogs such as nafarelin or buserelin; the success rates and ...
... buserelin acetate, with dimethyl-beta-cyclodextrin". Chem. Pharm. Bull. 45: 378-83. doi:10.1248/cpb.45.378. PMID 9118452. CS1 ...
H01CA01 Gonadorelin H01CA02 Nafarelin QH01CA90 Buserelin QH01CA91 Fertirelin QH01CA92 Lecirelin QH01CA93 Deslorelin QH01CA94 ...
... buserelin MeSH D06.472.420.740.320.340 --- goserelin MeSH D06.472.420.740.320.400 --- leuprolide MeSH D06.472.420.740.320.580 ...
Buserelin Deslorelin Fertirelin GnRH Gonadorelin Goserelin Histrelin Leuprorelin Nafarelin Triptorelin Abarelix Cetrorelix ...
L02AA03 Ethinylestradiol L02AA04 Fosfestrol L02AB01 Megestrol L02AB02 Medroxyprogesterone L02AB03 Gestonorone L02AE01 Buserelin ...
... buserelin - buspirone - busulfan - buthionine sulfoximine C cell - c-erbB-2 - c-kit - CA 19-9 assay - CA-125 - CA-125 test - ...
... buserelin (INN) Buspar (Bristol-Myers Squibb) Buspirex buspirone (INN) busulfan (INN) Busulfex (Orphan Medical) Butabarb ...
... buserelin MeSH D12.644.456.460.315 --- goserelin MeSH D12.644.456.460.480 --- leuprolide MeSH D12.644.456.460.600 --- nafarelin ...
... is marketed for medical use in both its free base (buserelin) and acetate salt (buserelin acetate) forms. Buserelin ... Buserelin is the generic name of the drug and its INN and BAN, while buserelin acetate is its USAN, BANM, and JAN, buséréline ... Buserelin is a peptide and an analogue of GnRH. Buserelin was first described in 1976 and was introduced for medical use in ... Buserelin and its metabolites are eliminated in the urine and bile, with approximately 50% of buserelin excreted in the urine ...
In the case of female patients who want to be treated with HCG Pubergen, Pregnyl:[30] a) Since infertile female patients who undergo medically assisted reproduction (especially those who need in vitro fertilization), are known to often be suffering from tubal abnormalities, after a treatment with this drug they might experience many more ectopic pregnancies. This is why early ultrasound confirmation at the beginning of a pregnancy (to see whether the pregnancy is intrauterine or not) is crucial. Pregnancies that have occurred after a treatment with this medicine are submitted to a higher risk of multiplets. Female patients who have thrombosis, severe obesity, or thrombophilia should not be prescribed this medicine as they have a higher risk of arterial or venous thromboembolic events after or during a treatment with HCG Pubergen, Pregnyl. b)Female patients who have been treated with this medicine are usually more prone to pregnancy losses. In the case of male patients: A prolonged treatment with ...
... receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system. Signals triggered by binding to the receptor are relayed within the cells by the cyclic AMP second messenger system. Gonadotropins are released under the control of gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and preoptic area of the hypothalamus. The gonads - testes and ovaries - are the primary target organs for LH and FSH. The gonadotropins affect multiple cell types and elicit multiple responses from the target organs. As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone (and indirectly estradiol), whereas FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles, as well as stimulating production of estrogen by the ovaries. Although gonadotropins are secreted in a pulsatile manner (as a result of pulsatile GnRH release), unlike the ...
Buserelin (buserelin acetate). *Deslorelin. *Fertirelin (fertirelin acetate). *Gonadorelin. *GnRH (LHRH, gonadorelin). * ...
Buserelin (buserelin acetate). *Deslorelin. *Fertirelin (fertirelin acetate). *GnRH (gonadorelin). *Goserelin (goserelin ...
Buserelin. *Deslorelin. *促性腺激素釋放激素. *Goserelin ...
Buserelin. *Deslorelin. *促性腺激素释放激素. *Goserelin ...
Buserelin (buserelin acetate). *Deslorelin. *Fertirelin (fertirelin acetate). *GnRH (gonadorelin). *Goserelin (goserelin ...
Buserelin is marketed for medical use in both its free base (buserelin) and acetate salt (buserelin acetate) forms. Buserelin ... Buserelin is the generic name of the drug and its INN and BAN, while buserelin acetate is its USAN, BANM, and JAN, buséréline ... Buserelin is a peptide and an analogue of GnRH. Buserelin was first described in 1976 and was introduced for medical use in ... Buserelin and its metabolites are eliminated in the urine and bile, with approximately 50% of buserelin excreted in the urine ...
A list of US medications equivalent to Buserelin Acetate is available on the Drugs.com website. ... Buserelin Acetate is a medicine available in a number of countries worldwide. ... Ingredient matches for Buserelin Acetate. Buserelin. Buserelin Acetate (BANM, JAN, USAN) is also known as Buserelin (Rec.INN) ... Buserelin Acetate. Buserelin Acetate may be available in the countries listed below. ...
Find information on Buserelin in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... buserelin is a sample topic from the Daviss Drug Guide. To view other topics, please sign in or purchase a subscription. ... Buserelin can be harmful to a fetus.. *SC Instruct patient in proper technique for self-injection, care and disposal of ... "Buserelin." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Washington Manual, www.unboundmedicine.com/washingtonmanual ...
Buserelin (Science: chemical) potent gonadorelin analog agonist. It has potential use as a female or male contraceptive and has ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Buserelin&oldid=19053" ...
They normally use buserelin injections, and they do reduce these to a maintanance dose, but they have no experience with the ... buserelin nasal spray. Discussion forum for those particularly interested in IVF and embryo transfer including frozen embryo ... Does any one out there know if you have to reduce the dose of buserelin nasal spray once you have achieved down regulation? Im ... buserelin nasal spray. by olliesmum » Tue Sep 27, 2005 8:20 pm ...
Buserelin / therapeutic use*. Clinical Protocols. Estradiol / analogs & derivatives*, blood, therapeutic use. Female. Humans. ... randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and ...
The aim of the present study was to investigate the effects of buserelin on the development of follicles, apoptosis index, and ... Objective: The aim of the present study was to investigate the effects of buserelin on the development of follicles, apoptosis ... Conclusion: The findings of this study suggest that short-term administration of high dose buserelin increases the serum ... Short-term Administration of Gonadotropin-releasing Hormone Agonist (Buserelin) Induces Apoptosis in Rat Ovarian Developmental ...
Buy Suprefact Depot (Buserelin Acetate) online at the guaranteed lowest price.Best Price RX contracts with a Canadian pharmacy ... If you find Suprefact Depot (Buserelin Acetate) for a lower price, contact us and we will match the price. You can shop with ...
Buserelin for women is used as part of fertility treatment. ... Buserelin is a synthetic form of a hormone which occurs ... Buserelin is also used in some disorders which affect men. There is a separate medicine leaflet called Buserelin for men which ... Buserelin for women Suprecur Authored by Helen Allen, 08 Sep 2015 Patient is a certified member of. The Information Standard ... Buserelin (brand name Suprecur®) is a hormone treatment for women.. Each time you collect your prescription for buserelin, ...
Buserelin treatment transiently increased the body weight after 5 and 9 weeks (p < 0.001). Increased estradiol in plasma and ... Forty rats were given the GnRH analog buserelin (20 μg, 1 mg/ml) or saline subcutaneously, once daily for 5 days, followed by 3 ... A marked enteric neuronal loss with modest effects on GI function is found after buserelin treatment. Increased feces fat ... were unchanged after buserelin treatment, but the relative number of submucous neurons containing somatostatin tended to be ...
GnRH agonist (buserelin) or HCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study ... GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study ... Reply: GnRH agonist (buserelin) or hCG for ovulation induction in gnRH antagonist IVF/ICSI cycles: a prospective randomized ... Combined Treatment With Buserelin and Tamoxifen in Premenopausal Metastatic Breast Cancer: a Randomized Study ...
Im on my day 10th day with buserelin. This is my first round in this adventure. Im having my period and I feel much more pain ... Brusing with Buserelin, am I doing something wrong?. i started my Buserelin injections on Wednesday so have done 4 now but 3 of ... Buserelin a quick one. Does it matter what time of day the buserelin injections are taken? I took them in the morning... ... Buserelin Does this delay your period? Im on day 27 of my cycle (8 days on buserelin) although I know not entirely... ...
sup>125I]buserelin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental ...
Mode of action of Buserelin. *Buserelin is among the Group of hypothalamic hormones and is a synthetically-produced hormone ... Application of the active substance: Buserelin. Buserelin is used for the treatment of hormone-dependent cancer of the prostate ... Buserelin. 02.06.2013 Author: admin Category: Antitumor Drug 0 Comment » The following substance not effective components are ... What interactions of Buserelin in fact pro active substance per injectione are known? It is important to note that the ...
buserelin answers are found in the Daviss Drug Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web ... buserelin is a sample topic from the Daviss Drug Guide. To view other topics, please sign in or purchase a subscription. ... Buserelin can be harmful to a fetus.. *SC: Instruct patient in proper technique for self-injection, care and disposal of ... TY - ELEC T1 - buserelin ID - 109846 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Daviss ...
Buserelin acetate (a derivative of Buserelin) is reported as an ingredient of Veterelin in the following countries:. *Ireland ...
Buserelin Beebeestar. 2 months ago. period? Im on day 27 of my cycle (8 days on buserelin) although I know not entirely ... Bring it on Buserelin! Heregoesthen77. a year ago. Ive just started down regging yesterday with Buserelin. Im doing this ... Triggering with Buserelin (Supercur). abcgirl. 4 months ago. Has anyone gone through IVF been triggered using Buserelin ( ... However, the clinic needs to be careful that you dont end up poorly, hence the Buserelin. All can still work out OK, and ...
Buserelin This medication is a gonadotropin-releasing hormone agonist, prescribed for prostate cancer and breast cancer.. More ...
In summary, buserelin reliably lowers the serum T level by week 4 in 95% of men. Treatment efficacy is equivalent to a ... In summary, buserelin reliably lowers the serum T level by week 4 in 95% of men. Treatment efficacy is equivalent to a ... In summary, buserelin reliably lowers the serum T level by week 4 in 95% of men. Treatment efficacy is equivalent to a ... In summary, buserelin reliably lowers the serum T level by week 4 in 95% of men. Treatment efficacy is equivalent to a ...
Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study.. ... Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study. ...
Buserelin is an analogue of gonadorelin with similar properties. It is used for the suppression of testosterone in the ... Buserelin is usually given as the acetate but doses are expressed in terms of the base 105 micrograms of buserelin acetate is ... The timing of buserelin dosage may also be important. Starting buserelin in the midluteal phase of the cycle has been reported ... Buserelin is an analogue of gonadorelin with similar properties. It is used for the suppression of testosterone in the ...
Buserelin is a luteinizing hormone-releasing hormone (LHRH) agonist, a synthetic hormone which stimulates the pituitary glands ... Buserelin (INN), Tiloryth (TN), AC1Q5OOQ, AC1L18ON, D-Ser(Tbu)6EA10LHRH, Molecular Formula: C60H86N16O13 Molecular Weight: ... Buserelin 57982-77-1 cas no D-Ser(Tbu)6EA10LHRH (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-( ... Buserelin acetate is marketed by Sanofi-Aventis under the brand name Suprefact and a generic form of Buserelin is now produced ...
GnRH agonists that have been marketed and are available for medical use include buserelin, gonadorelin, goserelin, histrelin, ... Agonists with two substitutions include: leuprolide, buserelin, histrelin, goserelin, and deslorelin. The agents nafarelin and ... Buserelin. Suprefact. Breast cancer; Endometrial hyperplasia; Endometriosis; Female infertility (assisted reproduction); ... GnRH agonists routinely used for this purpose are: buserelin, leuprorelin, nafarelin, and triptorelin.[8] ...
Manus Aktteva Biopharma LLP offers Buserelin, 57982-77-1, for RND and its crude form for your evaluation requirements with ... Buserelin. Buserelin is a Gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the ... Are you looking for Buserelin Intermediates ? Please click here to browse through the list of Buserelin Intermediates available ... Manus Aktteva Biopharma LLP offers Buserelin, 57982-77-1, for RND and its crude form for your evaluation requirements with ...
  • In ovulation induction, buserelin is used for pituitary suppression as an adjunct to gonadotropin administration. (wikipedia.org)
  • Gonadotrophin treatment is then added to buserelin therapy until an appropriate stage of follicular development, when both are withdrawn and chorionic gonadotrophin is given to induce ovulation. (sexualhealthmedicine.com)
  • Buserelin is given with gonadotrophic hormone therapy for induction of ovulation and as an aid to improving IVF procedures. (sexualhealthmedicine.com)
  • The aim of the present study was to investigate the effects of buserelin on the development of follicles, apoptosis index, and steroid hormones level. (uwi.edu)
  • Buserelin reduces the production of female sex hormones by acting on your pituitary gland. (patient.info)
  • By reducing the levels of these hormones, buserelin will help to relieve your symptoms. (patient.info)
  • Read also the information about the active group of hypothalamic hormones, among which the active ingredient of Buserelin. (dd-database.org)
  • Buserelin is among the Group of hypothalamic hormones and is a synthetically-produced hormone that is similar to a natural releasing hormone in the midbrain. (dd-database.org)
  • Buserelin may not be applied with hypersensitivity to the active substance or other LHRH analogues (hypothalamic hormones) and hormone resistance and after removal of the testicles. (dd-database.org)
  • Buserelin with gonadotrophic hormones has been found to result in pregnancies in women previously unresponsive to clomifene citrate, although there may be a greater risk of multiple births. (sexualhealthmedicine.com)
  • The findings of this study suggest that short-term administration of high dose buserelin increases the serum estradiol level and apoptosis in the granulosa cells but has an inhibitory effect on follicular development. (uwi.edu)
  • Total GI transit time, galactose absorption, zonulin levels in plasma, and antibody titers in serum were unaffected by buserelin treatment. (biomedcentral.com)
  • In summary, buserelin reliably lowers the serum T level by week 4 in 95% of men. (elsevier.com)
  • Side effects of buserelin are related to sex hormone deprivation and include symptoms of low testosterone levels and low estrogen levels such as hot flashes, sexual dysfunction, vaginal atrophy, and osteoporosis. (wikipedia.org)
  • Analysis of efficacy of testosterone suppression and toxicity included all 207 buserelin-treated patients. (elsevier.com)
  • The long-term use of buserelin in men decreases the testicular concentration of testosterone. (sexualhealthmedicine.com)
  • Is it true that there is a lower pregnancy rate etc from buserelin? (healthunlocked.com)
  • Starting buserelin in the midluteal phase of the cycle has been reported to produce more rapid pituitary down regulation and higher pregnancy rates from IVF than when buserelin was begun in the early follicular phase. (sexualhealthmedicine.com)