AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureNamed GroupsHealth CareGeographicals
Buruli UlcerMycobacterium ulceransSkin UlcerBeninMycobacterium Infections, NontuberculousGhanaSkin Diseases, BacterialWitchcraftStreptomycinStomach UlcerDuodenal UlcerMacrolidesDemocratic Republic of the CongoPeptic UlcerRifampinEndemic DiseasesTogoLeg UlcerPressure UlcerAngolaTuberculosis, CutaneousNeglected DiseasesCameroonBreakfastFootPeptic Ulcer HemorrhageEnvironmental MicrobiologyMicroscopyCommunicable Diseases, EmergingCommunity Health ServicesHospitals, StateChinaHospitals, PublicCommunity Health WorkersCommunity Health CentersHealth Status
Buruli Ulcer
A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.
Mycobacterium ulcerans
A slow-growing mycobacterium that infects the skin and subcutaneous tissues, giving rise to indolent BURULI ULCER.
Skin Ulcer
Benin
A republic in western Africa, south of NIGER and between TOGO and NIGERIA. Its capital is Porto-Novo. It was formerly called Dahomey. In the 17th century it was a kingdom in the southern area of Africa. Coastal footholds were established by the French who deposed the ruler by 1892. It was made a French colony in 1894 and gained independence in 1960. Benin comes from the name of the indigenous inhabitants, the Bini, now more closely linked with southern Nigeria (Benin City, a town there). Bini may be related to the Arabic bani, sons. (From Webster's New Geographical Dictionary, 1988, p136, 310 & Room, Brewer's Dictionary of Names, 1992, p60)
Mycobacterium Infections, Nontuberculous
Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.
Ghana
A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.
Skin Diseases, Bacterial
Skin diseases caused by bacteria.
Witchcraft
An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3d ed)
Streptomycin
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Duodenal Ulcer
A PEPTIC ULCER located in the DUODENUM.
Macrolides
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
Democratic Republic of the Congo
A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.
Peptic Ulcer
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Rifampin
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Endemic Diseases
The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)
Togo
A republic in western Africa, lying between GHANA on its west and BENIN on its east. Its capital is Lome.
Leg Ulcer
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
Pressure Ulcer
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.
Angola
A republic in southern Africa, southwest of DEMOCRATIC REPUBLIC OF THE CONGO and west of ZAMBIA. Its capital is Luanda.
Tuberculosis, Cutaneous
Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.
Neglected Diseases
Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).
Cameroon
A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.
Breakfast
The first meal of the day.
Foot
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Peptic Ulcer Hemorrhage
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
Environmental Microbiology
The study of microorganisms living in a variety of environments (air, soil, water, etc.) and their pathogenic relationship to other organisms including man.
Microscopy
The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.
Communicable Diseases, Emerging
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
Community Health Services
Diagnostic, therapeutic and preventive health services provided for individuals in the community.
Hospitals, State
Hospitals controlled by agencies and departments of the state government.
China
A country spanning from central Asia to the Pacific Ocean.
Hospitals, Public
Hospitals controlled by various types of government, i.e., city, county, district, state or federal.
Community Health Workers
Persons trained to assist professional health personnel in communicating with residents in the community concerning needs and availability of health services.
Community Health Centers
Facilities which administer the delivery of health care services to people living in a community or neighborhood.
Health Status
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.

Promising clinical efficacy of streptomycin-rifampin combination for treatment of buruli ulcer (Mycobacterium ulcerans disease). (1/134)

According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobe, Benin. Among the 224 (72%) eligible patients for whom treatment was initiated, 215 (96%) were categorized as treatment successes, and 9, including 1 death and 8 losses to follow-up, were treatment failures. Of the 215 successfully treated patients, 102 (47%) were treated exclusively with antibiotics and 113 (53%) were treated with antibiotics plus surgical excision and skin grafting. The size of lesions at treatment initiation was the major factor associated with surgical intervention: 73% of patients with lesions of >15 cm in diameter underwent surgery, whereas only 17% of patients with lesions of <5 cm had surgery. No patient discontinued therapy for side effects from the antibiotic treatment. One year after stopping treatment, 208 of the 215 patients were actively retrieved to assess the long-term therapeutic results: 3 (1.44%) of the 208 retrieved patients had recurrence of Mycobacterium ulcerans disease, 2 among the 107 patients treated only with antibiotics and 1 among the 108 patients treated with antibiotics plus surgery. We conclude that the WHO-recommended streptomycin-rifampin combination is highly efficacious for treating M. ulcerans disease. Chemotherapy alone was successful in achieving cure in 47% of cases and was particularly effective against ulcers of less than 5 cm in diameter.  (+info)

Systemic and local interferon-gamma production following Mycobacterium ulcerans infection. (2/134)

Buruli ulcer disease (BUD) is an emerging predominantly tropical disease caused by Mycobacterium ulcerans. The initial pre-ulcerative skin lesion often breaks down into an ulcer with undermined edges. Healing is common but may require considerable time, and scarring often results in functional limitations. Considerable evidence has now emerged that patients with early BUD cannot mount a sufficient protective T helper 1 (Th1) cell response to M. ulcerans, but uncertainty remains as to whether immune protection is restored over time. This study investigates the Th1 cell response of patients with various stages of BUD on mycobacterial antigens. We measured interferon (IFN)-gamma levels after ex vivo whole blood stimulation with tuberculin purified protein derivative (PPD), and compared the Th1 cell response of individuals with pre-ulcerative, ulcerative and healed BUD as well as healthy controls. Moreover, the systemic Th1 cell response was related to histopathological features in the various stages of surgically resected BUD lesions. We show that patients with ulcerative and healed BUD produce significantly higher IFN-gamma levels after mycobacterial ex vivo whole blood stimulation than healthy controls, and that patients with a granulomatous tissue response produce higher IFN-gamma levels than individuals without. We therefore suggest that the mounted Th1 cell response in ulcerative BUD patients might be related to their histopathological tissue response.  (+info)

Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans. (3/134)

BACKGROUND: Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome microarray analysis to explore insertion-deletion (InDel) polymorphism among a diverse strain collection of Mycobacterium ulcerans, the causative agent of the devastating skin disease, Buruli ulcer. Detailed analysis of large sequence polymorphisms in twelve regions of difference (RDs), comprising irreversible genetic markers, enabled us to refine the phylogenetic succession within M. ulcerans, to define features of a hypothetical M. ulcerans most recent common ancestor and to confirm its origin from Mycobacterium marinum. RESULTS: M. ulcerans has evolved into five InDel haplotypes that separate into two distinct lineages: (i) the "classical" lineage including the most pathogenic genotypes - those that come from Africa, Australia and South East Asia; and (ii) an "ancestral" M. ulcerans lineage comprising strains from Asia (China/Japan), South America and Mexico. The ancestral lineage is genetically closer to the progenitor M. marinum in both RD composition and DNA sequence identity, whereas the classical lineage has undergone major genomic rearrangements. CONCLUSION: Results of the InDel analysis are in complete accord with recent multi-locus sequence analysis and indicate that M. ulcerans has passed through at least two major evolutionary bottlenecks since divergence from M. marinum. The classical lineage shows more pronounced reductive evolution than the ancestral lineage, suggesting that there may be differences in the ecology between the two lineages. These findings improve the understanding of the adaptive evolution and virulence of M. ulcerans and pathogenic mycobacteria in general and will facilitate the development of new tools for improved diagnostics and molecular epidemiology.  (+info)

Environmental and health-related risk factors for Mycobacterium ulcerans disease (Buruli ulcer) in Benin. (4/134)

We conducted a case-control study to investigate the association between Buruli ulcer (BU) and environmental- and health-related behaviors in southern Benin. Hospital BU cases (N = 324) and sex- and age-matched neighborhood controls (N = 1,173) answered a questionnaire. Regular use of soap for washing, treating injuries with soap or antibiotic powder, and frequent contact with flowing water appeared protective against BU.  (+info)

Primary culture of Mycobacterium ulcerans from human tissue specimens after storage in semisolid transport medium. (5/134)

Tissue specimens collected from patients with clinically suspected Buruli ulcer treated in two Buruli ulcer treatment centers in Benin between 1998 and 2004 were placed in semisolid transport medium and transported at ambient temperature for microbiological analysis at the Institute of Tropical Medicine in Antwerp, Belgium. The impact of the delay before microbiological analysis on primary culture of Mycobacterium ulcerans was investigated. The length of storage in semisolid transport medium varied from 6 days to 26 weeks. Of the 1,273 tissue fragments positive for M. ulcerans DNA by an IS2404-specific PCR, 576 (45.2%) yielded positive culture results. The sensitivity of direct smear examination was 64.6% (822/1,273 tissue fragments). The median time required to obtain a positive culture result was 11 weeks. Positive cultures were obtained even from samples kept for more than 2 months at ambient temperatures. Moreover, there was no reduction in the viability of M. ulcerans, as detected by culture, when specimens remained in semisolid transport medium for long periods of time (up to 26 weeks). We can conclude that the method with semisolid transport medium is very robust for clinical specimens from patients with Buruli ulcer that, due to circumstances, cannot be analyzed in a timely manner. This transport medium is thus very useful for the confirmation of a diagnosis of Buruli ulcer with specimens collected in the field.  (+info)

Development of highly organized lymphoid structures in Buruli ulcer lesions after treatment with rifampicin and streptomycin. (6/134)

BACKGROUND: Buruli ulcer caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic necrotising skin ulcers. The pathogenesis is associated with the cytocidal and immunosuppressive activities of a macrolide toxin. Histopathological hallmark of progressing disease is a poor inflammatory response despite of clusters of extracellular bacilli. While traditionally wide excision of the infected tissue was the standard treatment, provisional WHO guidelines now recommend an eight week pre-treatment with streptomycin and rifampicin. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a detailed immunohistochemical analysis of tissue samples from Buruli patients who received antibiotic treatment. Cellular immune response along with bacterial load and distribution were monitored. We demonstrate that this treatment leads to the development of highly organized cellular infiltration surrounding areas of coagulative necrosis. Diffuse infiltrates, granulomas and dense lymphocyte aggregation close to vessels were observed. Mycobacterial material was primarily located inside mononuclear phagocytes and microcolonies consisting of extracellular rod-shaped mycobacteria were no longer found. In observational studies some patients showed no clinical response to antibiotic treatment. Corresponding to that, one of five lesions analysed presented with huge clusters of rod-shaped bacilli but no signs of infiltration. CONCLUSIONS/SIGNIFICANCE: Results signify that eight weeks of antibiotic treatment reverses local immunosuppression and leads to an active inflammatory process in different compartments of the skin. Structured leukocyte infiltrates with unique signatures indicative for healing processes developed at the margins of the lesions. It remains to be analysed whether antibiotic resistance of certain strains of M. ulcerans, lacking patient compliance or poor drug quality are responsible for the absent clinical responses in some patients. In future, analysis of local immune responses could serve as a suitable surrogate marker for the efficacy of alternative treatment strategies.  (+info)

Risk factors for buruli ulcer: a case control study in Cameroon. (7/134)

BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. This disease is associated with areas where the water is slow-flowing or stagnant. However, the exact mechanism of transmission of the bacillus and the development of the disease through human activities is unknown. METHODOLOGY/PRINCIPAL FINDINGS: A case-control study to identify Buruli ulcer risk factors in Cameroon compared case-patients with community-matched controls on one hand and family-matched controls on the other hand. Risk factors identified by the community-matched study (including 163 pairs) were: having a low level of education, swamp wading, wearing short, lower-body clothing while farming, living near a cocoa plantation or woods, using adhesive bandages when hurt, and using mosquito coils. Protective factors were: using bed nets, washing clothes, and using leaves as traditional treatment or rubbing alcohol when hurt. The family-matched study (including 118 pairs) corroborated the significance of education level, use of bed nets, and treatment with leaves. CONCLUSIONS/SIGNIFICANCE: Covering limbs during farming activities is confirmed as a protective factor guarding against Buruli ulcer disease, but newly identified factors including wound treatment and use of bed nets may provide new insight into the unknown mode of transmission of M. ulcerans or the development of the disease.  (+info)

Short report: edematous Mycobacterium ulcerans infection (Buruli ulcer) on the face: a case report. (8/134)

We report a case of a four-year-old Angolan boy with the edematous form of Buruli ulcer on the face and scalp, who was treated at a rural hospital in the Bas-Congo Province, Democratic Republic of Congo. Treatment consisted of a series of surgical interventions and antimycobacterial chemotherapy (rifampin and ciprofloxacin) for two months. This case demonstrates the diagnostic and management difficulties of an edematous lesion of BU on the face and suggests an enhancement of healing and limitation of extent of excision by specific antibiotherapy. The outcome in this patient also underscores the importance of prompt referral of suspected cases and training of health professionals in the early diagnosis of BU.  (+info)

KNUSTSpace: Persisting Social Participation Restrictions among Former Buruli Ulcer Patients in Ghana and BeninKNUSTSpace: Persisting Social Participation Restrictions among Former Buruli Ulcer Patients in Ghana and Benin
Background: Buruli ulcer may induce severe disabilities impacting on a persons well-being and quality of life. Information about long-term disabilities and participation restrictions is scanty. The objective of this study was to gain insight into participation restrictions among former Buruli ulcer patients in Ghana and Benin. Methods: In this cross-sectional study, former Buruli ulcer patients were interviewed using the Participation Scale, the Buruli Ulcer Functional Limitation Score to measure functional limitations, and the Explanatory Model Interview Catalogue to measure perceived stigma. Healthy community controls were also interviewed using the Participation Scale. Trained native interviewers conducted the interviews. Former Buruli ulcer patients were eligible for inclusion if they had been treated between 2005 and 2011, had ended treatment at least 3 months before the interview, and were at least 15 years of age. Results: In total, 143 former Buruli ulcer patients and 106 community ...
http://dspace.knust.edu.gh/handle/123456789/11868
Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin - Archive ouverte HALBuruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin - Archive ouverte HAL
|p|Author Summary Buruli ulcer is known to be endemic to Nigeria since at least 1967, however epidemiological data are rare and incomplete. In total, only 51 Buruli ulcer patients were described in 45 years, all found in Southern Nigeria. This is likely a result of the lack of adequate public health structures dedicated to the diagnosis and treatment of Buruli ulcer in the region. Here, we report a large cohort of 127 PCR-confirmed Nigerian patients treated in neighbouring Benin. Nigerian patients presented mainly severe lesions of Buruli ulcer, and this is linked by the fact that period prior consultation is delayed (24% of the patients waited more than one year between the beginning of the lesion and the consultation in the Buruli ulcer treatment centre in Pobè). We identify South Western Nigeria as an important endemic area for Buruli ulcer, and believe our results will be of importance to Nigerian health authorities, the World Health Organisation and NGOs involved in management of Buruli ulcer.|/p
https://hal.archives-ouvertes.fr/hal-01392239
Staphylococcus aureus in patients with Buruli ulcer and burns in Ghana</em>...Staphylococcus aureus in patients with Buruli ulcer and burns in Ghana</em>...
TY - THES. T1 - Staphylococcus aureus in patients with Buruli ulcer and burns in Ghana. AU - Amissah, Nana Ama. PY - 2017. Y1 - 2017. N2 - Wounds of the skin are highly susceptible to secondary infections by bacteria, especially in healthcare settings with limited resources and lack of infection prevention and control practices. To assess the possible implications of bacterial wound colonization in a resource-limited setting, this PhD research addressed the colonization of Buruli ulcers and burn wounds in Ghana by the bacterial pathogen Staphylococcus aureus. Buruli ulcer is a serious necrotizing skin disease caused by Mycobacterium ulcerans, a close relative of the bacteria causing tuberculosis and leprosy. Burn injuries are the most devastating of all injuries, and ~90% of burns occur in low- and middle-income countries. Previous studies showed that wounds of Buruli ulcer and burn patients are colonized with a variety of microorganisms including S. aureus, which may interfere with wound ...
https://research.rug.nl/en/publications/staphylococcus-aureus-in-patients-with-buruli-ulcer-and-burns-in-
Sequelae of Mycobacterium ulcerans infections (Buruli ulcer), European Journal of Plastic Surgery | 10.1007/s002389900111 |...Sequelae of Mycobacterium ulcerans infections (Buruli ulcer), European Journal of Plastic Surgery | 10.1007/s002389900111 |...
Read Sequelae of Mycobacterium ulcerans infections (Buruli ulcer), European Journal of Plastic Surgery on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/sequelae-of-mycobacterium-ulcerans-infections-buruli-ulcer-0AnjW0qJDH
Buruli Ulcer Disease (Mycobacterium Ulcerans Infection) | Open MichiganBuruli Ulcer Disease (Mycobacterium Ulcerans Infection) | Open Michigan
The Buruli ulcer disease is due to infection by Mycobacterium ulcerans. This programme describes the basic pathophysiology of the disease, the typical clinical presentations, and the management of cases with complicated features. The program should be informative for both medical students and practitioners who wish to increase their knowledge about this serious tropical disease.. Authors: Richard Phillips, Stephen Sarfo, Emmanuel Adu, Cary Engleberg, Veronica Owusu-Afriyie. Institutions: Kwame Nkrumah University of Science and Technology, University of Michigan. ...
https://open.umich.edu/find/open-educational-resources/global-health/buruli-ulcer-disease-mycobacterium-ulcerans-infection
Buruli Ulcer: Promising New Drug Candidate Against a Forgotten DiseaseBuruli Ulcer: Promising New Drug Candidate Against a Forgotten Disease
Buruli ulcer - one of the most neglected among the NTDs - is a debilitating and stigmatising disease. Affecting mainly children in West and Central Africa, the chronic disease results in devastating skin lesions and can lead to permanent disfigurement and long-term disabilities. Buruli ulcer is caused by Mycobacterium ulcerans which belongs to the same family of bacteria that cause tuberculosis (TB) and leprosy. M. ulcerans is found in the environment and, despite considerable research efforts, the mode of transmission of the bacteria to humans remains unclear.. Difficult treatment with adverse side effects. Traditionally, the skin lesions caused by Buruli ulcer have been removed by wide surgical excision. Since 2004, the World Health Organization (WHO) also recommends treatment with a combination of antibiotics: oral rifampicin and injected streptomycin. Surgery is often not an accessible option in low-income settings and the combination therapy requires daily visits in health centres over an ...
https://news.idw-online.de/2018/12/18/buruli-ulcer-promising-new-drug-candidate-against-a-forgotten-disease/
Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease -...Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease -...
Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the hosts protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly
https://hal-pasteur.archives-ouvertes.fr/pasteur-01384561
Ecology and Transmission of Buruli Ulcer Disease: A Systematic Review by Richard W. Merritt, Edward D. Walker et al.Ecology and Transmission of Buruli Ulcer Disease: A Systematic Review by Richard W. Merritt, Edward D. Walker et al.
Buruli ulcer is a neglected emerging disease that has recently been reported in some countries as the second most frequent mycobacterial disease in humans after tuberculosis. Cases have been reported from at least 32 countries in Africa (mainly west), Australia, Southeast Asia, China, Central and South America, and the Western Pacific. Large lesions often result in scarring, contractual deformities, amputations, and disabilities, and in Africa, most cases of the disease occur in children between the ages of 4-15 years. This environmental mycobacterium, Mycobacterium ulcerans, is found in communities associated with rivers, swamps, wetlands, and human-linked changes in the aquatic environment, particularly those created as a result of environmental disturbance such as deforestation, dam construction, and agriculture. Buruli ulcer disease is often referred to as the mysterious disease because the mode of transmission remains unclear, although several hypotheses have been proposed. The above review
https://ecommons.udayton.edu/bio_fac_pub/22/
Implementation of a decentralized community-based treatment program to improve the management of Buruli ulcer in the Ouinhi...
TY - JOUR. T1 - Implementation of a decentralized community-based treatment program to improve the management of Buruli ulcer in the Ouinhi district of Benin, West Africa. AU - Amoussouhoui, Arnaud Setondji. AU - Sopoh, Ghislain Emmanuel. AU - Wadagni, Anita Carolle. AU - Johnson, Roch Christian. AU - Aoulou, Paulin. AU - Agbo, Inès Elvire. AU - Houezo, Jean Gabin. AU - Boyer, Micah. AU - Nichter, Mark. PY - 2018/3/12. Y1 - 2018/3/12. N2 - Background: Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In Benin, BU patient care is being integrated into the government health system. In this paper, we report on an innovative pilot program designed to introduce BU decentralization ...
https://arizona.pure.elsevier.com/en/publications/implementation-of-a-decentralized-community-based-treatment-progr
On the transmission dynamics of Buruli ulcer in Ghana : insights through a mathematical modelOn the transmission dynamics of Buruli ulcer in Ghana : insights through a mathematical model
Background: Mycobacterium ulcerans is know to cause the Buruli ulcer. The association between the ulcer and environmental exposure has been documented. However, the epidemiology of the ulcer is not well understood. A hypothesised transmission involves humans being bitten by the water bugs that prey on mollusks, snails and young fishes. Methods: In this paper, a model for the transmission of Mycobacterium ulcerans to humans in the presence of a preventive strategy is proposed and analysed. The model equilibria are determined and conditions for the existence of the equilibria established. The model analysis is carried out in terms of the reproduction number R0. The disease free equilibrium is found to be locally asymptotically stable for R0 , 1. The model is fitted to data from Ghana. Results: The model is found to exhibit a backward bifurcation and the endemic equilibrium point is globally stable when R0 , 1. Sensitivity analysis showed that the Buruli ulcer epidemic is highly influenced by the ...
https://scholar.sun.ac.za/handle/10019.1/100528?show=full
Risk factors for buruli ulcer: a case control study in CameroonRisk factors for buruli ulcer: a case control study in Cameroon
BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. This disease is associated with areas where the water is slow-flowing or stagnant. However, the exact mechanism of transmission of the bacillus and the development of the disease through human activities is unknown. METHODOLOGY/PRINCIPAL FINDINGS: A case-control study to identify Buruli ulcer risk factors in Cameroon compared case-patients with community-matched controls on one hand and family-matched controls on the other hand. Risk factors identified by the community-matched study (including 163 pairs) were: having a low level of education, swamp wading, wearing short, lower-body clothing while farming, living near a cocoa plantation or woods, using adhesive bandages when hurt, and using mosquito coils. Protective factors were: using bed nets, washing clothes, and using leaves as traditional treatment or rubbing alcohol when hurt. The family-matched study (including 118 pairs) corroborated ...
https://fieldresearch.msf.org/handle/10144/116351
KNUSTSpace: Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease...KNUSTSpace: Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease...
Background: Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU), is unique among human pathogens in its capacity to produce a polyketide-derived macrolide called mycolactone, making this molecule an attractive candidate target for diagnosis and disease monitoring. Whether mycolactone diffuses from ulcerated lesions in clinically accessible samples and is modulated by antibiotic therapy remained to be established. Methodology/Principal Finding: Peripheral blood and ulcer exudates were sampled from patients at various stages of antibiotic therapy in Ghana and Ivory Coast. Total lipids were extracted from serum, white cell pellets and ulcer exudates with organic solvents. The presence of mycolactone in these extracts was then analyzed by a recently published, fieldfriendly method using thin layer chromatography and fluorescence detection. This approach did not allow us to detect mycolactone accurately, because of a high background due to co-extracted human lipids. We thus used a ...
http://dspace.knust.edu.gh/handle/123456789/11867
WHO | Previous Global Buruli Ulcer Initative EventsWHO | Previous Global Buruli Ulcer Initative Events
The World Health Organization (WHO) in collaboration with the Ministry of Health of Ghana organized a four-week training course on the management of Buruli ulcer for 21 doctors from 11 countries at the Agogo Presbyterian Hospital, Agogo in the Ashanti Akim North district. The participants were from Benin, Cameroon, Congo, Côte dIvoire, Democratic Republic of the Congo, Ghana, Guinea, Sudan, Uganda, Papua New Guinea and Togo. The course was facilitated by plastic surgeons from Australia, Côte dIvoire, Ghana, Switzerland and France. The Minister of Health, Major Courage E. K. Quashigah (Rtd), opened the course under the chairmanship of Nana Kwame Akuoko Sarpong, Paramount Chief of Agogo Traditional Council. The main objective of the course was to train doctors working in endemic areas to improve their capacities to manage of Buruli ulcer and its complications. Those trained will support their national programmes to train health workers in their respective countries in a standardized manner. It ...
http://www.who.int/buruli/events/past_events/en/
Buruli ulcer disease : prospects for a vaccine - edocBuruli ulcer disease : prospects for a vaccine - edoc
Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD is a mutilating disease leading to severe disability; it is the third most common mycobacterial infection in immunocompetent people after tuberculosis and leprosy. It is most endemic in West Africa, but cases have been reported from more than 30 countries. Treatment with antibiotics is possible, long-lasting and requires injections; there are cases of treatment failures, and the disease is prone to resistance. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas, and could be used as a therapeutic vaccine to shorten the duration of treatment and prevent relapses. There is considerable evidence supporting the notion that generation of a vaccine is feasible. This article reviews the present state of the art with special emphasis on the immunology of the infection and the prospects for development of a ...
https://edoc.unibas.ch/19508/
The American Journal of Tropical Medicine and Hygiene | Emergence of Buruli Ulcer Disease in the Daloa Region of Cote D&apos...The American Journal of Tropical Medicine and Hygiene | Emergence of Buruli Ulcer Disease in the Daloa Region of Cote D&apos...
Abstract Recent reports have suggested increases in Buruli ulcer (BU), an infection caused by Mycobacterium ulcerans in west Africa. In 1991, we conducted surveillance for BU in a rural area of Cote d'Ivoire and identified 312 cases of active or healed ulceration. A case-control study was then performed to investigate risk factors for this infection. The rate of illness did not appear to differ between males and females (5.2% versus 7.5%; P = 0.11). The highest rate of illness was seen in the 10-14-year-old age group (143 cases per 1,000 population). New cases increased more than three-fold between 1987 and 1991, and local prevalence of BU was as high as 16.3%. Twenty-six percent of persons with healed ulcers had chronic functional disability. Participation in farming activities near the main river in the region was identified in the case-control study as a risk factor for infection (odds ratio [OR] for each 10-min decrease in walking distance between the fields and the river = 1.52, 95% confidence
http://www.ajtmh.org/content/journals/10.4269/ajtmh.1995.52.219
WHO | WHO Annual meeting on Buruli ulcer, 15-17 March 2006WHO | WHO Annual meeting on Buruli ulcer, 15-17 March 2006
You will find below the presentations made during the WHO annual meeting on Buruli ulcer on country activities. The PowerPoint presentations have been converted into Pdf format. Should you like to obtain a presentation in the original format, please send a request to [email protected] ...
http://www.who.int/buruli/events/presentations_countries/en/
Risk Factors for Buruli Ulcer in Ghana-A Case Control Study in the Suhum-Kraboa-Coaltar and Akuapem South Districts of the...
Background: Buruli ulcer (BU) is a skin disease caused by Mycobacterium ulcerans. Its exact mode of transmission is not known. Previous studies have identified demographic, socio-economic, health and hygiene as well as environment related risk factors. We investigated whether the same factors pertain in Suhum-Kraboa-Coaltar (SKC) and Akuapem South (AS) Districts in Ghana which previously were not endemic for BU. Methods: We conducted a case control study. A case of BU was defined as any person aged 2 years or more who resided in study area (SKC or AS District) diagnosed according to the WHO clinical case definition for BU and matched with age-(+/-5 years), gender-, and community controls. A structured questionnaire on host, demographic, environmental, and behavioural factors was administered to participants. Results: A total of 113 cases and 113 community controls were interviewed. Multivariate conditional logistic regression analysis identified presence of wetland in the neighborhood (OR = 3.9, ...
https://pub.uni-bielefeld.de/publication/2710586
Identifying Biological and Environmental Indicators of Emerging Infectious Diseases: The Case of Buruli Ulcer | BOREA Research...Identifying Biological and Environmental Indicators of Emerging Infectious Diseases: The Case of Buruli Ulcer | BOREA Research...
Understanding disease ecology is vital in preventing future outbreaks of established infections and to predict the emergence of new pathogens. In recent decades there have been a number of high profile infectious diseases which have swept across countries and in some cases the world. Many of these begin as generalist emerging infections; such microbes are difficult to study in the wild due to their inherently ambiguous life histories and complex associations with numerous hosts and the environment. In this PhD a number of techniques are used to pinpoint and further understand the life history of one such pathogen Mycobacterium ulcerans, the causative agent of Buruli ulcer, in the hope that this data can be used to predict and prevent future outbreaks and can be applied to other emerging infections. The results of this study include the first identification of the pathogen in the environment for a whole new continent, South America. Further to this it has led to the discovery of the likely ...
https://borea.mnhn.fr/en/identifying-biological-and-environmental-indicators-emerging-infectious-diseases-case-buruli-ulcer
Socioeconomic implications of Buruli ulcer in Ghana: a three-year review. | The American Journal of Tropical Medicine and...Socioeconomic implications of Buruli ulcer in Ghana: a three-year review. | The American Journal of Tropical Medicine and...
This study examines some of the socioeconomic cost of treating 102 cases of Buruli ulcer between 1994 and 1996 at the St. Martin's Catholic Hospital in Agroyesum in the Amansie West district of the Ashanti region of Ghana. Seventy percent of the cases were children (up to 15 years of age). There was no sex difference in the distribution of cases. Hospitalization was prolonged (average = 186 days in 1994, 103 days in 1995, and 102 days in 1996) with no significant age and sex differences. There were 10 limb amputations, 12 patients were left with contracture deformities, one patient lost sight in one eye, and two died of sepsis and tetanus. The average total treatment cost per patient was $966.85 (62% indirect) in 1994, $706.08 (75% indirect) in 1995, and $658.74 (79% indirect) in 1996. With increasing number of cases, high treatment costs, and serious complications, urgent attention should be given to the disease in terms of control and research efforts aimed at early detection and treatment.
http://www.ajtmh.org/content/journals/10.4269/ajtmh.1998.59.1015
What is the Buruli Ulcer Epidemic? | Passport HealthWhat is the Buruli Ulcer Epidemic? | Passport Health
A flesh-eating bacteria is now reaching epidemic levels, spreading to 30 countries. Most cases of Buruli Ulcers come from sub-Saharan Africa, but Australia has dealt with the disease for years. While we know some methods to treat the disease, scientists are still unsure about its history or how to stop the spread.
https://www.passporthealthusa.com/2018/05/what-is-the-buruli-ulcer-epidemic/
The mystifying Buruli ulcer that is infecting Victorians in Bairnsdale, Bellarine Peninsula and the Mornington PeninsulaThe mystifying Buruli ulcer that is infecting Victorians in Bairnsdale, Bellarine Peninsula and the Mornington Peninsula
Its the bug that has the scientific community baffled. Just what is causing the flesh-eating Buruli ulcer to march along Victorias coast towards Melbourne?
https://www.brisbanetimes.com.au/national/victoria/stigma-isolation-the-flesh-eating-ulcer-infecting-hundreds-more-victorians-each-year-20190709-p525h4.html?ref=rss&utm_medium=rss&utm_source=rss_feed
Figure 2 - Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging...
We report a case of Buruli ulcer in a tourist from the United Kingdom. The disease was almost certainly acquired in Brazil, where only 1 case had previously been reported. The delay in diagnosis highlights the need for physicians to be aware of the disease and its epidemiology.
https://wwwnc.cdc.gov/eid/article/15/11/09-0460-f2
Buruli Ulcer - GlossaryBuruli Ulcer - Glossary
Looking for simple explanations to difficult medical terms that tend to puzzle you? This glossary can help you to easily understand medical terms related to the article on Buruli Ulcer
https://www.medindia.net/patients/patientinfo/buruli-ulcer-glossary.htm
5- Receptors | FLT3 tyrosine kinase inhibitors in acute myeloid leukemia5- Receptors | FLT3 tyrosine kinase inhibitors in acute myeloid leukemia
Background Buruli ulcer is a serious individual skin disease due to species remains to be a matter of controversy, and relevant interventions to avoid this disease lack (we) the correct understanding of the life span history attributes in its organic aquatic ecosystem and (ii) immune system signatures that might be correlates of security. within a Buruli ulcerCendemic region (in the Republic of Benin, Western world Africa), we assayed sera gathered from either ulcer-free people or sufferers with Buruli ulcers for the titre of IgGs that bind to insect predator SGH, concentrating on those substances been shown to be maintained by colonies otherwise. IgG titres had been low in the Buruli ulcer individual group than in the ulcer-free group. Conclusions These data shall help framework potential investigations in Buruli ulcerCendemic areas, offering a rationale for analysis into individual immune system signatures of contact SAT1 with predatory aquatic pests, with special focus on those insect saliva ...
http://su5614.info/category/5-receptors/
Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others<...Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others<...
TY - JOUR. T1 - Paradoxical Reactions: Anti-Tumor Necrosis Factor Alpha Agents, Ustekinumab, Secukinumab, Ixekizumab, and Others. AU - Puig, Lluís. PY - 2017/1/1. Y1 - 2017/1/1. N2 - © 2018 S. Karger AG, Basel. Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease. Paradoxical reactions have subsequently been reported with other biological drugs or classes (e.g., tocilizumab), even though in some cases insufficient efficacy or phenotype switch may be difficult to differentiate ...
https://portalrecerca.uab.cat/en/publications/paradoxical-reactions-anti-tumor-necrosis-factor-alpha-agents-ust
Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events | The Journal of...Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events | The Journal of...
The pathogenesis of Buruli ulcers is thought to be essentially mediated by the production of mycolactone at the site of infection (6). The extensive tissue necrosis and minimal inflammation in Buruli ulcers constitute the hallmarks of these lesions, and reflect the cytocidal and immunosuppressive properties of this original macrolide (1). Mycolactone is able to diffuse rapidly within target cells, as shown by the cytosolic accumulation of fluorescent derivatives (31). Mycolactone then triggers diverse cytopathic effects, including cytoskeletal rearrangements and cell cycle arrest, eventually culminating in apoptotic/necrotic cell death (9). The manifestations and levels of mycolactone cytotoxicity vary extensively among cell types, suggesting that the molecular target of mycolactone may be differentially expressed or have different functions in different cells. At noncytostatic and cytotoxic concentrations, mycolactone displays immunomodulatory properties on human primary monocytes and dendritic ...
http://www.jimmunol.org/content/184/3/1436.long
IJERPH | Free Full-Text | Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli...IJERPH | Free Full-Text | Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli...
Non-tuberculous mycobacteria (NTM), particularly mycolactone producing mycobacteria (MPM), are bacteria found in aquatic environments causing skin diseases in humans like Buruli ulcer (BU). Although the causative agent for BU, Mycobacterium ulcerans has been identified and associated with slow-moving water bodies, the real transmission route is still unknown. This study aimed to characterize MPMs from environmental aquatic samples collected in a BU non-endemic community, Adiopodoumé, in Côte dIvoire. Sixty samples were collected in four types of matrices (plant biofilms, water filtrate residues, plant detritus and soils) from three water bodies frequently used by the population. Using conventional polymerase chain reaction (PCR), MPMs were screened for the 16S ribosomal RNA (rRNA) mycobacterial gene, the IS2404 insertion sequence, and MPM enoyl reductase (ER) gene. Variable Number Tandem Repeat (VNTR) typing with loci 6, 19, mycobacterial interspersed repetitive unit 1 (MIRU1) and sequence type 1(ST1
http://www.mdpi.com/1660-4601/14/2/178
Genetic Diversity of the Bacteria That Cause Buruli Ulcer RevealedGenetic Diversity of the Bacteria That Cause Buruli Ulcer Revealed
Study lays the groundwork for development of a cost-effective tool for studying the population structure and spread of Mycobacterium ulcerans
http://www.medindia.net/news/Genetic-Diversity-of-the-Bacteria-That-Cause-Buruli-Ulcer-Revealed-57918-1.htm
Beating Buruli in Victoria - health.vicBeating Buruli in Victoria - health.vic
Information on a research project that aims to better understand how Buruli ulcer is transmitted and determine effective ways to prevent infections and reduce infections.
https://www2.health.vic.gov.au/beatingburuli
Treat Early and Broad: Thermotherapy of Buruli Ulcer Integrated Into WHOrecommended Wound Management in West Africa - No Study...Treat Early and Broad: Thermotherapy of Buruli Ulcer Integrated Into WHOrecommended Wound Management in West Africa - No Study...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details ...
https://www.clinicaltrials.gov/ct2/show/results/NCT03957447?recrs=a&view=record
Epidemiology of Buruli ulcer in Amansie West district, Ghana. - PubMed - NCBIEpidemiology of Buruli ulcer in Amansie West district, Ghana. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/8296362?dopt=Abstract
Buruli ulcer | Africa TimesBuruli ulcer | Africa Times
Launched in July 2015, Africa Times is an independent participative online news site for Sub-Saharan Africa. We aim to empower all African voices through publishing content by a range of people, from academics to bloggers. We are dedicated to bringing the world an African view on life, up-to-date African news and analysis. ...
http://africatimes.com/tag/buruli-ulcer/
Disease InfoSearch - Buruli ulcer - Definition, causes, resources and support information
Are you looking for disease information or support? Simply type in the name of a disease or condition and Disease InfoSearch will locate quality information from a database of more than 13,000 diseases and thousands of support groups and foundations.
http://resourcerepository.org/Bairnsdale+ulcer/1003
Paradoxical reaction to caffeine
Recognizing and managing paradoxical reactions from benzodiazepines & propofol. In retrospect, he may have been having a paradoxical reaction to
http://buydiflucancvv.com/inderal+10mg/paradoxical-reaction-to-caffeine-3f/
Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic...Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic...
Results: Thirty-two of 156 (21%) patients developed paradoxical reactions a median 39 days (IQR 20-73 days) from antibiotic initiation. Forty-two paradoxical episodes occurred with 26 (81%) patients experiencing one and 6 (19%) multiple episodes. Thirty-two (76%) episodes occurred during antibiotic treatment and 10 (24%) episodes occurred a median 37 days after antibiotic treatment. The reaction site involved the original lesion (wound) in 23 (55%), was separate to but within 3 cm of the original lesion (local) in 11 (26%) and was more than 3 cm from the original lesion (distant) in 8 (19%) episodes. Mycobacterial cultures were negative in 33/33 (100%) paradoxical episodes. Post-February 2009 treatment involved more cases with no antibiotic modifications (12/15 compared with 11/27, OR 5.82, 95% CI 1.12-34.07, p = 0.02) and no further surgery (9/15 compared with 2/27, OR 18.75, 95% CI 2.62-172.73, p , 0.001). Six severe cases received prednisone with marked clinical improvement. On multivariable ...
http://dro.deakin.edu.au/view/DU:30059331
Paul Converse, PhD | Center for Tuberculosis ResearchPaul Converse, PhD | Center for Tuberculosis Research
My research interests concern the pathogens, Mycobacterium tuberculosis and M. ulcerans, in humans and experimental animal hosts. Studies in tuberculosis, principally in the mouse model, concern the response to chemotherapeutic agents, including novel compounds and novel combinations of drugs, and their modulation due to innate host factors and those involving the immune system after immunotherapeutic vaccination. Studies on M. ulcerans, the causative agent of Buruli ulcer, have focused on the differential response to vaccination in different mouse strains and the evaluation of novel chemotherapy regimens in comparison with the WHO standard of rifampin and streptomycin. We are also involved in studies to develop appropriate assays to detect mycolactone, the toxin that is the principal virulence factor of M. ulcerans.. ...
http://tbcenter.jhu.edu/people/paul-converse-phd/
Neglected Tropical Diseases - Institute for Immunology and Informatics (iCubed)Neglected Tropical Diseases - Institute for Immunology and Informatics (iCubed)
Approximately 1 billion people - one sixth of the worlds population - suffer from one or more neglected tropical diseases. The World Health Organization has defined Neglected Tropical Diseases as diseases that affect a majority of the developing world but have been underfunded in terms of research and product development dollars. They include (among others): Buruli ulcer, Chagas disease, Cholera, Dengue, Dracunculensis, Leishmaniasis, Onchocerciasis, Schistosomiasis, and Trachoma. Genomes for many of these pathogens are becoming available due to research efforts worldwide, and so the iCubed is collaborating with researchers to identify new epitopes and design vaccines using the CCHI funded iVAX toolkit. The iCubed runs a training session per year - following these training sessions, NTD researchers can gain access to a dedicated website containing their genomes of choice for their own epitope-mapping use.. ...
http://i-cubed.org/vaccine-immunology/neglected-tropical-diseases/
Search | InfolepSearch | Infolep
A community based study on the mode of transmission, prevention and treatment of Buruli ulcers in Southwest Cameroon: knowledge, attitude and practices ...
https://www.leprosy-information.org/search?aresult=4&f%5B0%5D=bibcite_reference_year_of_publication%3A2016&f%5B1%5D=keywords%3A51501&node=24137
Tuberculosis of the skin | RSM Videos
Rod Hay lectures on infectious diseases and the skin. He covers diseases such as leprosy, lupus and buruli ulcer, and then focuses on tuberculosis. Hay talks about the diagnosis of these conditions and different techniques of management, as well how drug resistance affects treatment around the world. This lecture was part of an event called SECs sells: Skin, eyes and chests at The Royal Society of Medicine in London.. Date of lecture: 13th March 2014. This video is available for iPad via Safari. Length: 00:20:12 ...
https://videos.rsm.ac.uk/video/tuberculosis-of-the-skin
Eric Nuermberger, MD | Center for Tuberculosis ResearchEric Nuermberger, MD | Center for Tuberculosis Research
nuermbergerlab.com. The primary research focus in my laboratory is translational research related to the development of new drugs and regimens to improve the treatment of important mycobacterial infections, including tuberculosis (TB), Buruli ulcer and other diseases caused by nontuberculous mycobacteria. We approach the problem using both established and emerging animal and in vitro models of infection and relying on pharmacodynamic principles. Our major goal is to identify and optimize new drugs and drug combinations to shorten and/or simplify treatment and restrict the emergence of drug resistance. Over the past 18 years, we have worked with a variety of public and private sponsors and partners to inform the development of a number of new and repurposed drugs, including moxifloxacin, rifapentine, bedaquiline, pretomanid, sutezolid, and linezolid, as well as novel regimens containing these drugs. We continue to refine existing models and develop new models for pre-clinical drug efficacy ...
http://tbcenter.jhu.edu/people/eric-nuermberger-md/
ASMscience | Paradoxical Reactions an
The immune response to mycobacterial infection is complex, involving several arms of the immune system. Organs are damaged by mycobacteria directly and also by the necrotic granulomatous immune response of the host to this pathogen. Ideally, mycobacterial infection is met with a balanced immune response that is sufficient to kill organisms but not so severe as to cause excessive tissue injury. Immunosuppression may promote growth of mycobacteria while decreasing tissue injury by the host response to the infection. Conversely, enhancement of the hosts immune response may kill more organisms but may also result in more organ damage.
https://www.asmscience.org/content/book/10.1128/9781555819866.chap38
Likumi.lv - Latvijas Republikas tiesību aktiLikumi.lv - Latvijas Republikas tiesību akti
Tiesību akti un to izmaiņas: visi jaunumi un arhīvs. Sistematizēti tiesību akti. Plašas meklēšanas un personalizētās iespējas. Vietni uztur „Latvijas Vēstnesis
http://likumi.lv/jaunumi/67
SearchSearch
Kichik waqitlirimizdiki naxshilar
Ishinimenki, kopinchimiz bu naxshini tunji qitim anglighanda choqum bashqa tilda anglighan BU esli nusqisi iken, kichik waqtimizdin qalghan eslimiler
http://uyghur-oqughuchilar.forumotion.net/t143-kichik-waqitlirimizdiki-naxshilar
Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in...Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in...
Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue.. Case Presentations: We report on three patients misdiagnosed as suffering from Buruli ulcer, who did not respond to Buruli treatment. Histopathological review of the tissue sections from these patients suggests basidiobolomycosis. All patients had been lost to follow-up, and none received antifungal therapy. On visiting the patients at their homes, two were reported to have died ...
https://www.sciensano.be/en/biblio/subcutaneous-granulomatous-inflammation-due-basidiobolomycosis-case-reports-3-patients-buruli-ulcer
Buruli Ulcer Mycobacterium ulcerans Infection Prepared by: A. Elkader Y. Elottol Supervisor: Prof M. Shubir. - ppt downloadBuruli Ulcer Mycobacterium ulcerans Infection Prepared by: A. Elkader Y. Elottol Supervisor: Prof M. Shubir. - ppt download
Disease caused by Mycobacterium ulcerans. First described by MacCallum in 1948, but the name came from Buruli country in Uganda. The third most common Mycobacterium, that affected more than 30 countries.
http://slideplayer.com/slide/4372537/
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model | Nature CommunicationsThe compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model | Nature Communications
Buruli ulcer (BU) is an emerging infectious disease that causes disfiguring skin ulcers. The causative agent, Mycobacterium ulcerans, secretes toxin called mycolactone that triggers inflammation and immunopathology. Existing treatments are lengthy and consist of drugs developed for tuberculosis. Here, we report that a pyrazolo[1,5-a]pyridine-3-carboxamide, TB47, is highly bactericidal against M. ulcerans both in vitro and in vivo. In the validated mouse model of BU, TB47 alone reduces M. ulcerans burden in mouse footpads by more than 2.5 log10 CFU compared to the standard BU treatment regimen recommended by the WHO. We show that mutations of ubiquinol-cytochrome C reductase cytochrome subunit B confer resistance to TB47 and the dissimilarity of CydABs from different mycobacteria may account for their differences in susceptibility to TB47. TB47 is highly potent against M. ulcerans and possesses desirable pharmacological attributes and low toxicity that warrant further assessment of this agent for
https://www.nature.com/articles/s41467-019-08464-y?utm_campaign=MultipleJournals_USG_MICRO&utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Microbiology-Global&error=cookies_not_supported&code=840d11e6-2e8e-40b1-b914-83cfc86eafab
Outcomes for mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern...Outcomes for mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern...
OBrien, DP, Hughes, A, Cheng, A, Rogers, Margaret, Callan, P, McDonald, A, Holten, I, Birrell, M, Sowerby, J, Johnson, PD and Athan, Eugene 2007, Outcomes for mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern Australian case series, The Medical journal of Australia. ...
http://dro.deakin.edu.au/view/DU:30087218
Figure 2 - Mycobacterium ulcerans Disease, Peru - Volume 14, Number 3-March 2008 - Emerging Infectious Disease journal - CDC
Eight adult patients (ages 18-58, 5 women) with Buruli ulcer (BU) confirmed by at least 2 diagnostic methods were seen in a 10-year period. Attempts to culture Mycobacterium ulcerans failed. Five patients came from jungle areas, and 3 from the swampy northern coast of Peru. The patients had 1-5 lesions, most of which were on the lower extremities. One patient had 5 clustered gluteal lesions; another patient had 2 lesions on a finger. Three patients were lost to follow-up. All 5 remaining patients had moderate disease. Diverse treatments (antituberculous drugs, World Health Organization [WHO] recommended antimicrobial drug treatment for BU, and for 3 patients, excision surgery) were successful. Only 1 patient (patient 7) received the specific drug treatment recommended by WHO. BU is endemic in Peru, although apparently infrequent. Education of populations and training of health workers are first needed to evaluate and understand the full extent of BU in Peru.
https://wwwnc.cdc.gov/eid/article/14/3/07-0904-f2
Primary cultivation : factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical...Primary cultivation : factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical...
Background: While cultivation of pathogens represents a foundational diagnostic approach in the study of infectious diseases, its value for the confirmation of clinical diagnosis of Buruli ulcer is limited by the fact that colonies of Mycobacterium ulcerans appear only after about eight weeks of incubation at 30°C. However, for molecular epidemiological and drug sensitivity studies, primary isolation of M. ulcerans remains an essential tool. Since for most of the remote Buruli ulcer endemic regions of Africa cultivation laboratories are not easily accessible, samples from lesions often have to be stored for extended periods of time prior to processing. The objective of the current study therefore was to determine which transport medium, decontamination method or other factors decrease the contamination rate and increase the chance of primary isolation of M. ulcerans bacilli after long turnover time. Methods: Swab and fine needle aspirate (FNA) samples for the primary cultivation were collected ...
https://edoc.unibas.ch/35080/
PLOS Neglected Tropical Diseases: A Major Role for Mammals in the Ecology of Mycobacterium ulceransPLOS Neglected Tropical Diseases: A Major Role for Mammals in the Ecology of Mycobacterium ulcerans
Author Summary Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a destructive skin disease found predominantly in sub-Saharan Africa and south-eastern Australia. The mode of transmission and environmental reservoir remain unknown, but several studies have explored the role of aquatic insects, such as water bugs, and biting insects, such as mosquitoes. In the present study we investigated possible environmental source(s) of M. ulcerans in Victoria, Australia. Our results revealed that although M. ulcerans DNA could be detected at low levels in a variety of environmental samples, the highest concentrations of M. ulcerans DNA were found in the faeces of two species of possums, common ringtails and common brushtails. Possums are small arboreal marsupial mammals, native to Australia, and these particular species occur in both urban and rural areas. Examination and sampling of live captured possums in an area endemic for BU revealed that 38% of ringtail possums and 24% of brushtail possums,
http://journals.plos.org/plosntds/article/related?id=10.1371/journal.pntd.0000791&imageURI=info:doi/10.1371/journal.pntd.0000791.g005
Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence<...
TY - JOUR. T1 - Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence. AU - Mve-Obiang, A. AU - Lee, RE. AU - Portaels, F. AU - Small, PLC. N1 - ITG-M1B; ITG-M3A; MICRO; U-MYCOB; JIF; DOI; PDF; Reprints-R; CHAU. PY - 2003. Y1 - 2003. KW - B780-tropical-medicine. KW - Bacterial diseases. KW - Mycobacterial diseases. KW - Buruli ulcer. KW - Mycobacterium ulcerans. KW - Virulence. KW - Strains. KW - Heterogeneity. KW - Mycolactones. U2 - 10.1128/IAI.71.2.774-783.2003. DO - 10.1128/IAI.71.2.774-783.2003. M3 - A1: Web of Science-article. VL - 71. SP - 774. EP - 783. JO - Infection and Immunity. JF - Infection and Immunity. SN - 0019-9567. IS - 2. ER - ...
https://research.itg.be/en/publications/heterogeneity-of-mycolactones-produced-by-clinical-isolates-of-my
Management of Mycobacterium ulcerans infection in a pregnant woman in Benin using rifampicin and clarithromycin. - PubMed -...Management of Mycobacterium ulcerans infection in a pregnant woman in Benin using rifampicin and clarithromycin. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/18976206?dopt=Abstract
Mycobacterium ulcerans disease in the middle belt of Ghana: an eight-year review from six endemic districts | Virtual Health...Mycobacterium ulcerans disease in the middle belt of Ghana: an eight-year review from six endemic districts | Virtual Health...
Mycobacterium ulcerans [MU] produces mycolactone toxin when infected with a plasmid. Toxin is cytotoxic and immunosuppressive, causing extensive destruction of tissues, leading to large ulcers on exposed parts of the body. Spontaneous healing by secondary intention leads to contractures, subluxation of joints, disuse atrophy, distal lymphedema and other complications. The disease is endemic in some communities within the middle belt of Ghana. To document the clinical and epidemiological features of MU disease in the middle belt of Ghana and the outcome of treatment. Patients with lesions suspected to MU disease were screened by community workers. Lesions were confirmed by any of the following: direct smear examination, culture, polymerase chain reaction [PCR] , or histopathology. Patients were treated with rifampicin [10 mg/kg orally] and streptomycin [15 mg/kg IM] combination for eight weeks. Patients selected for surgical treatment included cases where medical treatment had failed, cases where ...
https://vlibrary.emro.who.int/imemr/mycobacterium-ulcerans-disease-in-the-middle-belt-of-ghanaan-eight-year-review-from-six-endemic-districts-2/
Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system - Institut...Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system - Institut...
Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal distribution of mycolactone remained largely unknown. Here, we used the zebrafish model to provide the first global kinetic analysis of mycolactones diffusion in vivo, and multicellular co-culture systems to address the critical question of the toxins access to the brain. Zebrafish larvae were injected with a fluorescent-derivative of mycolactone to visualize the in vivo diffusion of the toxin from the peripheral circulation. A rapid, body-wide distribution of mycolactone was observed, with selective accumulation in tissues near the injection site and brain, together with an important excretion through the gastro-intestinal tract. Our conclusion that mycolactone reached the central nervous system was
https://hal-pasteur.archives-ouvertes.fr/pasteur-03046953
Buruli ulcer Fact Sheet | Africa Health OrganisationBuruli ulcer Fact Sheet | Africa Health Organisation
In most cases, experienced health professionals in endemic areas can make a reliable clinical diagnosis.. Depending on the patients age, the patients geographical area, the location of lesions, and the extent of pain experienced, other conditions should be excluded from the diagnosis. These other conditions include tropical phagedenic ulcers, chronic lower leg ulcers due to arterial and venous insufficiency (often in the older and elderly populations), diabetic ulcers, cutaneous leishmaniasis, extensive ulcerative yaws and ulcers caused by Haemophilus ducreyi1.. Early nodular lesions are occasionally confused with boils, lipomas, ganglions, lymph node tuberculosis, onchocerciasis nodules or other subcutaneous infections such as fungal infection.. In Australia, papular lesions may initially be confused with an insect bite.. Cellulitis may look like oedema caused by M. ulcerans infection but in the case of cellulitis, the lesions are painful and the patient is ill and febrile.. HIV infection is ...
https://aho.org/fact-sheets/buruli-ulcer-fact-sheet/
Publication | Luxembourg Institute of HealthPublication | Luxembourg Institute of Health
Buruli ulcer (BU) is an infectious skin disease caused by Mycobacterium ulcerans. It mainly affects poor communities living close to bodies of water. In the absence of early treatment, this neglected disease can cause lasting deformities and may require limb amputation. It is reported in 34 countries and is the third most common mycobacterial disease in immunocompetent patients. Considerable progress has been made in treatment and prevention. The Cotonou Declaration (2009) describes the recommended control strategies. Although effective, current control strategies are limited because they do not take into account all the factors that influence emergence, prevention and cure of the disease. The control of Buruli ulcer mainly depends on intervention on social, cultural and psychosocial factors that influence preventive and self-care behaviour. The health promotion approach requires collaboration with populations in order to perform simultaneous actions on BU factors in the community setting. ...
https://www.lih.lu/crp/publication/community-based-approaches-in-the-fight-against-buruli-ulcer-review-of-the-literature-13134
Neglected Tropical Diseases - GLRAIndia- Transforming lives & restoring confidenceNeglected Tropical Diseases - GLRAIndia- Transforming lives & restoring confidence
The Buruli ulcer disease mainly affects children under the age of 15, the reason for which is unknown and no research has been conducted about this, nor indeed into the methods of infection of this rare disease.In Africa, DAHW,Germany in partnership with Ludwig Maximilian University of Munich, the Bernhard Nocht Institute for Tropical Medicine in Hamburg and long term partner Fondation Follereau Luxembourg (FFL)is working to achieve better diagnosis for patients and to finally find the causes of Buruli Ulcer.. More than 500 million people in India are at risk for one or more of the worlds five most prevalent NTDs: Lymphatic Filariasis (LF), Trachoma, and Soil transmitted Helminths (STHs) including Hookworm, Roundworm and Whipworm.. India has some of the largest and longstanding NTD programs in the world, but an additional 300 million people are in need of treatment. Global progress on NTDs hinges on Indias efforts and successes. India can scale up its efforts and serve as a model of success ...
http://glraindia.org/neglected-tropical-diseases/
In vitro susceptibility of Mycobacterium ulcerans to clarithromycin<...
TY - JOUR. T1 - In vitro susceptibility of Mycobacterium ulcerans to clarithromycin. AU - Portaels, F. AU - Traoré, H. AU - De Ridder, K. AU - Meyers, WM. PY - 1998. Y1 - 1998. KW - B780-tropical-medicine. KW - Bacteriology. KW - Mycobacterium ulcerans. KW - Drug sensitivity. KW - Clarithromycin. M3 - A1: Web of Science-article. VL - 42. SP - 2070. EP - 2073. JO - Antimicrobial Agents and Chemotherapy. JF - Antimicrobial Agents and Chemotherapy. SN - 0066-4804. ER - ...
https://research.itg.be/en/publications/in-vitro-susceptibility-of-mycobacterium-ulcerans-to-clarithromyc
LSHTM Research OnlineLSHTM Research Online
Nackers, F; Tonglet, R; Slachmuylder, V; Johnson, RC; Robert, A; Zinsou, C; Glynn, JR; Portaels, F; Gala, JL; (2007) Association between haemoglobin variants S and C and Mycobacterium ulcerans disease (Buruli ulcer): a case-control study in Benin. Tropical medicine & international health, 12 (4). pp. 511-518. ISSN 1360-2276 DOI: https://doi.org/10.1111/j.1365-3156.2006.01808.x Full text not available from this repository ...
https://researchonline.lshtm.ac.uk/view/keywords/Sickle_Cell.html
mycolactone - oi
A family of toxins produced by Mycobacterium ulcerans; strains from different geographic areas produce distinct patterns of mycolactone congeners. Mycolactone has significant immunosuppressive effects and inhibits production of macrophage inflammatory protein (MIP-1α), MIP-1β, RANTES, interferon-γ-inducible protein 10, and monocyte chemoattractant protein 1, but not IL-12, TNFα, or IL-6. See Buruli ulcer. ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803100219526
BU-SPONT-HEAL | CNAGBU-SPONT-HEAL | CNAG
Buruli ulcer (BU) is a neglected emerging infectious disease caused by Mycobacterium ulcerans. BU has become the third most prevalent mycobacteriosis worldwide, after tuberculosis and leprosy. Limited knowledge of the disease and the fact that it affects mainly poor rural communities contribute to underreporting of cases. Nevertheless, there are 6000 reported cases every year, of which more than 50% are children under the age of 15. For these reasons, the World Health Organization (WHO) has recognized BU as an emerging infectious disease with an important public health impact; that is both devastating for the individual and catastrophic for the economy of affected households.. M. ulcerans produces a dermonecrotic toxin, mycolactone, which induces extensive destruction of the skin and soft tissues with the formation of large ulcers, as well as bone and joint lesions. No specific vaccine is currently available for BU and because the disease progresses without pain or fever, treatment is frequently ...
http://cnag.crg.eu/projects/bu-spont-heal
Paradoxical reactions might be actually the vector of increased watering of the mouth
I in then realized that my increased watering of the mouth nor did nt occur usually until i started taking Clonazepam. Prolonged maintenance therapy with other salicylates, particularly Clonazepam, should grants be administered cautiously in ovulatory patients with or predisposed her to paradoxical reactions. Then again, even those without chronic loss appears in sexual reproductive ability, desire, drive, or performance prior to taking Desipramine may suddenly become mor
http://rosesturn.com/new-doxepin-increased-watering-of-the-mouth-drug-in-the-works.html
Paradoxical reaction to Xanax (alprazolam)
Anyone have a dog thats experienced a paradoxical reaction to Xanax? Today I learned that Button, apparently, is one of the small percentage of dogs that become extremely excited and hyper on the stuff ... hes taken it before, but I never remembered him having any negative response to it. Last time we were at the vet, they gave us a slightly higher dose to use before we visit the office because were trying to make the vets office a bit less horrifying for him. So I gave him the meds, waited half an hour, put him in the car and we got there, and instead of being relaxed, he was pumped. Totally into everything and more interested in the dogs and people than usual ... it was sort of weird, but not that dramatic until we got home. From about 2 PM until 4, it was like Button was on cocaine. He tore around the house, barked his fool head off almost nonstop, forgot he had any manners and jumped up on the counters looking for food, grabbed things out of my hands, raced in and out of the backyard, ...
http://www.pitbullforum.com/viewtopic.php?f=5&t=151484&start=0
Mycolactone displays anti-inflammatory effects on the nervous system • Research - Institut PasteurMycolactone displays anti-inflammatory effects on the nervous system • Research - Institut Pasteur
BACKGROUND: Mycolactone is a macrolide produced by the skin pathogen Mycobacterium ulcerans, with cytotoxic, analgesic and immunomodulatory properties. The latter were recently shown to result from mycolactone blocking the Sec61-dependent production of pro-inflammatory mediators by immune cells. Here we investigated whether mycolactone similarly affects the inflammatory responses of the nervous cell subsets involved in pain perception, transmission and maintenance. We also investigated the effects of mycolactone on the neuroinflammation that is associated with chronic pain in vivo.
https://research.pasteur.fr/en/publication/mycolactone-displays-anti-inflammatory-effects-on-the-nervous-system/
MUL 0004 - UPF0232 protein MUL 0004 - Mycobacterium ulcerans (strain Agy99) - MUL 0004 gene & proteinMUL 0004 - UPF0232 protein MUL 0004 - Mycobacterium ulcerans (strain Agy99) - MUL 0004 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
https://www.uniprot.org/uniprot/A0PKB5
Neglected Tropical Disease Treatment Market Size, Share, Trend And Forecast 2028Neglected Tropical Disease Treatment Market Size, Share, Trend And Forecast 2028
Neglected Tropical Disease Treatment Market, By Disease (Dengue, Trachoma, Buruli Ulcer, Yaws, Chagas Disease, Leishmaniases), By Product Type (Drugs, Vaccines), By Region (North America, Europe, Asia Pacific, Middle East & Africa, and South America) - Ma
https://www.quincemarketinsights.com/industry-analysis/neglected-tropical-disease-treatment-market/68012
Flesh-eating ulcer spreading in Australia, and reasons remain a mysteryFlesh-eating ulcer spreading in Australia, and reasons remain a mystery
Scientists in Australia have voiced concern about an apparent outbreak of Buruli ulcer, a flesh-eating disease that usually occurs in West and central Africa.
https://www.wgal.com/article/flesh-eating-ulcer-spreading-in-australia-and-reasons-remain-a-mystery-1523954257/19836177
Flesh-eating ulcer spreading in Australia, and reasons remain a mysteryFlesh-eating ulcer spreading in Australia, and reasons remain a mystery
Scientists in Australia have voiced concern about an apparent outbreak of Buruli ulcer, a flesh-eating disease that usually occurs in West and central Africa.
https://www.ksbw.com/article/flesh-eating-ulcer-spreading-in-australia-and-reasons-remain-a-mystery-1523954257/19836177
Leprosy Mailing List Blog: Research groups discussing on future priority researchesLeprosy Mailing List Blog: Research groups discussing on future priority researches
For example, in the recently held meeting of the Disease Reference Group (DRG) for Research on Tuberculosis (TB), Leprosy and Buruli Ulcer, leprosy group was invited to a one day activity in a 3-day meeting wherein TB had the full agenda. We are just lucky that Dr Diana Lockwood was there, otherwise, no other leprosy expert was around to discuss with us. I do appreciate though the support I am getting from Dr Steve Lyons as far as multi-drug therapy drug supply is concerned but even if there is a Global NTD meetings, leprosy programme is not equally represented, from our end it is the Filaria programme which is given priority and called upon on these meetings ...
http://leprosymailinglist.blogspot.co.uk/2010/11/research-groups-discussing-on-future.html
Tag Archive for Patient Stories - ReSurge AfricaTag Archive for Patient Stories - ReSurge Africa
Kwasi Boakye was 8 years old when he was brought to the Reconstructive Plastic Surgery and Burns Unit in Accra in April 2005. Buruli Ulcer had started near his eye.... Read More » ...
https://resurgeafrica.org/tag/patient-story/
ray ban aviators 29.99 - Discount Hot Ray Ban Caribbean RB4148 Sunglasses Black Frame Purple Lens outlet online store - Ray Ban...
ray ban aviators 29.99 - Discount Hot Ray Ban Caribbean RB4148 Sunglasses Black Frame Purple Lens outlet online store - Ray Ban Justin Buruli ulcer Documents compiled up in.
http://www.raybanjustin.us/ray-ban-aviators-29.99-n-184.html
Suppressive effect of mycolactone-containing fraction from Mycobacterium ulcerans on antibody production against co...Suppressive effect of mycolactone-containing fraction from Mycobacterium ulcerans on antibody production against co...
OA Text is an independent open-access scientific publisher showcases innovative research and ideas aimed at improving health by linking research and practice to the benefit of society.
https://www.oatext.com/Suppressive-effect-of-mycolactone-containing-fraction-from-Mycobacterium-ulcerans-on-antibody-production-against-co-administered-antigens.php
RCSB PDB - 4EGE: Crystal Structure of Dipeptidase PepE from Mycobacterium ulceransRCSB PDB - 4EGE: Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/4ege
A prospective controlled study to determine the duration of antibiotherapy in the patients with elevated serum PSA levels -...
A prospective controlled study to determine the duration of antibiotherapy in the patients with elevated serum PSA levels - Minerva Urologica e Nefrologica 2016 June;68(3):270-4 - Minerva Medica - Journals
https://www.minervamedica.it/en/journals/minerva-urology-nephrology/article.php?cod=R19Y2016N03A0270
Infliximab treatment-induced paradoxical psoriasiform reaction in patient with psoriasis vulgaris showing positive lymphocyte...Infliximab treatment-induced paradoxical psoriasiform reaction in patient with psoriasis vulgaris showing positive lymphocyte...
IFN-a: interferon alfa LTT: lymphocyte transportation test TNF-a: tumor necrosis factorealfa T umor necrosis factor alfa (TNF-a) antagonists are commonly used to treat inflammatory disorders and are considered particularly effective in the treatment of moderate to severe psoriasis. Paradoxically, however, new-onset occurrence orworsening of psoriasis has been increasingly recognized among patients treated with TNF-a antagonists. We report on a 60-year-old man who developed a severe psoriatic condition with diffuse alopecia during infliximab therapy for psoriasis, resulting in the discontinuation of infliximab. Lymphocyte transportation test (LTT) results were positive. Currently, there are few reports of LTTpositive cases that are related to paradoxical reactions by TNF-a antagonists. We discuss the relationship between paradoxical reaction and the mechanisms of LTT.
https://www.semanticscholar.org/paper/Infliximab-treatment-induced-paradoxical-psoriasif-Ishii-Osai-Yoneta/539595636e7209968a6248613c1f2839511f7038
A0PKB2 | SWISS-MODEL Repository
SWISS-MODEL Repository entry for A0PKB2 (DNAA_MYCUA), Chromosomal replication initiator protein DnaA. Mycobacterium ulcerans (strain Agy99)
https://swissmodel.expasy.org/repository/uniprot/A0PKB2
Australian Smoke Crosses the South Pacific : December 2006Australian Smoke Crosses the South Pacific : December 2006
During the month of December 2006, large forest fires in drought-stricken southeastern Australia produced vast clouds of smoke. Southern hemisphere winds then carried the smoke along several paths to Antarctica and South America. The SeaWiFS composites below give daily snapshots of the eastward progress of the various smoke clouds. (Click on any of the globes to view the corresponding larger version. A small animation is also available with arrows pointing out the various positions of the smoke clouds during the course of the time series.) ...
https://oceancolor.gsfc.nasa.gov/SeaWiFS/HTML/SeaWiFS.Dec2006.AustralianSmokeTimeSeries.html
Zenfolio | Alexey Danilchenko Photography | Birds | The Laughing Kookaburra
Taken in Birdsworld (Hampshire) The Laughing Kookaburra is one of the larger members of the Kingfisher family and is widespread throughout southeastern Australia. They live on insects, worms and crustaceans, as well as small snakes and frogs, and pair for life.
https://www.aletan.com/p304390361/h588A1CD
Giant Water Bug Facts | Insects in EducationGiant Water Bug Facts | Insects in Education
Giant Water Bugs live up to their name-most measure more than 2 inches long-and they arent afraid to hunt prey much larger than themselves!
http://www.saferbrand.com/advice/insect-library/insect-education/giant-water-bug
LENOSTI BU POZDRAVENA PDF
LENOSTI BU POZDRAVENA PDF - by Corinne Maier First published January 1st Sort by. title, original Published September 12th by Vintage . Lenosti, buď pozdravena! O umění a. Solms, M.,
https://epsscentral.info/lenosti-bu-pozdravena-73/
Buruli ulcerBuruli ulcer
... does not spread from one person to another. In areas endemic for Buruli ulcer, disease occurs near stagnant bodies ... Röltgen K, Pluschke G (April 2019). "Buruli ulcer: history and disease burden". In Pluschke G, Röltgen K (eds.). Buruli ulcer: ... In 1998, WHO established the Global Buruli Ulcer Initiative to coordinate global efforts to eliminate Buruli ulcer. WHO ... Johnson PD (April 2019). "Buruli ulcer in Australia". In Pluschke G, Röltgen K (eds.). Buruli ulcer: Mycobacterium ulcerans ...
https://en.wikipedia.org/wiki/Buruli_ulcer
Global Buruli Ulcer InitiativeGlobal Buruli Ulcer Initiative
"Buruli ulcer". Emory University. Retrieved 31 October 2020. "WHO Technical Advisory Group on Buruli ulcer". World Health ... Röltgen K, Pluschke G (2019). "Buruli ulcer: history and disease". In Pluschke G, Röltgen K (eds.). Buruli Ulcer: Mycobacterium ... The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to ... Amofah G, Bonsu F, Tetteh C (February 2002). "Buruli Ulcer in Ghana: Results of a National Case Search". Emerging Infectious ...
https://en.wikipedia.org/wiki/Global_Buruli_Ulcer_Initiative
Neglected tropical diseasesNeglected tropical diseases
"Buruli Ulcer". World Health Organization. Archived from the original on 11 May 2016. Retrieved 2 May 2016. "Buruli Ulcer". ... ND=Not Determined Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. It is related to the family of organisms that ... The prevalence of Buruli ulcer is unknown. The risk of mortality is low, although secondary infections can be lethal. Morbidity ... For guinea worm, Buruli ulcer, or cutaneous leishmaniasis, wound management is needed to speed up healing and reduce disability ...
https://en.wikipedia.org/wiki/Neglected_tropical_diseases
RifampicinRifampicin
"Revisiting Buruli Ulcer". The Journal of Dermatology. 42 (11): 1033-41. doi:10.1111/1346-8138.13049 Perlroth J, Kuo M, Tan J, ... It is also used in the treatment of Mycobacterium ulcerans infections as associated with Buruli ulcer, usually in combination ...
https://en.wikipedia.org/wiki/Rifampicin
MycolactoneMycolactone
"Buruli ulcer disease". Fact sheets. WHO. March 2007. Retrieved 24 March 2012. Pidot SJ, Hong H, Seemann T, Porter JL, et al. ( ... In humans, mycolactone is the toxin responsible for Buruli ulcers, doing so by damaging tissues and inhibiting the immune ...
https://en.wikipedia.org/wiki/Mycolactone
Mycobacterium ulceransMycobacterium ulcerans
Röltgen K, Pluschke G (2019). "Buruli Ulcer: History and Disease Burden". In Röltgen K, Pluschke G (eds.). Buruli Ulcer: ... The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is ... Demangel C, Stinear TP, Cole ST (2009). "Buruli ulcer: reductive evolution enhances pathogeneicity of Mycobacterium ulcerans". ... Buruli Ulcer: Mycobacterium Ulcerans Disease. Cham: Springer. pp. 107-115. doi:10.1007/978-3-030-11114-4_6. ISBN 978-3-030- ...
https://en.wikipedia.org/wiki/Mycobacterium_ulcerans
Tropical ulcerTropical ulcer
Unlike Buruli ulcer, tropical ulcers are very painful. Lesions begin with inflammatory papules that progress into vesicles and ... of the chronic ulcers that persists for more than three years Tetanus: by entry of tetanus bacilli through the ulcer.[citation ... Ulcers occur on exposed parts of the body, primarily on anterolateral aspect of the lower limbs and may erode muscles and ... Once developed, the ulcer may become chronic and stable, but also it can run a destructive course with deep tissue invasion, ...
https://en.wikipedia.org/wiki/Tropical_ulcer
Wayne M. MeyersWayne M. Meyers
This illness is most commonly called Buruli ulcer. Surgery is usually required and often causes extensive sequels. The best ... There was a lot of material on other mycobacterial diseases, such as Buruli ulcer, (Mycobacterium ulcerans infections) which is ... Together they published 56 major medical investigations on Buruli ulcer which led to major advancements in the diagnosis and ... Meyers was particularly well known for his work with Hansen's disease (Leprosy), Buruli ulcer, and filarial diseases. Meyers ...
https://en.wikipedia.org/wiki/Wayne_M._Meyers
Neglected tropical diseases in IndiaNeglected tropical diseases in India
Buruli ulcer is not a problem in India.[citation needed] In 2019 physicians identified a case of Buruli ulcer in India, but the ... "Buruli ulcer: Rare presentation of a chronic nonhealing ulcer in India". Indian Journal of Vascular and Endovascular Surgery. 6 ...
https://en.wikipedia.org/wiki/Neglected_tropical_diseases_in_India
Ellis Owusu-DaboEllis Owusu-Dabo
"KCCR attains global recognition in Buruli ulcer diagnostics". BusinessGhana. Retrieved 2020-09-11. "Asantehene urges more ...
https://en.wikipedia.org/wiki/Ellis_Owusu-Dabo
John Grange (immunologist)John Grange (immunologist)
This followed a stay in Zaire to study the Buruli ulcer. His doctoral thesis was on the classification of certain rapidly ...
https://en.wikipedia.org/wiki/John_Grange_(immunologist)
Gordon AwandareGordon Awandare
The center has expanded to study malaria, Buruli ulcer, HIV, and tuberculosis. In 2015, Awandare was awarded the Royal Society ...
https://en.wikipedia.org/wiki/Gordon_Awandare
BCG vaccineBCG vaccine
Buruli ulcer: BCG may protect against or delay the onset of Buruli ulcer. BCG has been one of the most successful ... BCG also has some effectiveness against Buruli ulcer infection and other nontuberculous mycobacterial infections. Additionally ... A small ulcer may also form with some scarring after healing. Side effects are more common and potentially more severe in those ...
https://en.wikipedia.org/wiki/BCG_vaccine
James Augustus GrantJames Augustus Grant
It may be the first recorded case and first description of Mycobacterium ulcerans infection (Buruli ulcer). The print in his ...
https://en.wikipedia.org/wiki/James_Augustus_Grant
SitafloxacinSitafloxacin
... (INN; also called DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. ...
https://en.wikipedia.org/wiki/Sitafloxacin
RifalazilRifalazil
Chlamydia infection Clostridium difficile associated diarrhea Trachoma Tuberculosis Leprosy Buruli ulcer "Rifalazil - 129791-92 ...
https://en.wikipedia.org/wiki/Rifalazil
WitchcraftWitchcraft
... epilepsy and the common severe bacterial Buruli ulcer. The word is over a thousand years old: Old English formed the compound ...
https://en.wikipedia.org/wiki/Witchcraft
Richard MorrowRichard Morrow
... and he studied infectious diseases such as buruli ulcers. From 1970 to 1976, Morrow was a professor of international health at ...
https://en.wikipedia.org/wiki/Richard_Morrow
Kids for World HealthKids for World Health
Buruli ulcer, Chagas disease, and leishmaniasis. Kids For World Health's motto is "Life is important for all people, rich or ...
https://en.wikipedia.org/wiki/Kids_for_World_Health
David Ofori-AdjeiDavid Ofori-Adjei
Buruli ulcer, and HIV/AIDS and public sector pharmaceutical management. He is currently the Editor-in-Chief of the Ghana ...
https://en.wikipedia.org/wiki/David_Ofori-Adjei
Volunteer Partnerships for West AfricaVolunteer Partnerships for West Africa
... tuberculosis and Buruli Ulcer. VPWA also networks with other organizations, companies and institutions to implement holistic ...
https://en.wikipedia.org/wiki/Volunteer_Partnerships_for_West_Africa
Foundation for Innovative New DiagnosticsFoundation for Innovative New Diagnostics
... buruli ulcer), and tuberculosis. Alongside this, FIND works on diagnostic connectivity, antimicrobial resistance, acute febrile ...
https://en.wikipedia.org/wiki/Foundation_for_Innovative_New_Diagnostics
David Barker (epidemiologist)David Barker (epidemiologist)
"Buruli ulcer"), demonstrating that it was caused, not by mosquitos, but by wounds caused by the razor-sharp reeds growing near ...
https://en.wikipedia.org/wiki/David_Barker_(epidemiologist)
MycobacteriumMycobacterium
"Buruli", or "Bairnsdale" ulcer M. pseudoshottsii M. shottsii M. florentinum M. genavense M. heidelbergense M. interjectum M. ...
https://en.wikipedia.org/wiki/Mycobacterium
List of pollution-related diseasesList of pollution-related diseases
Amoebiasis Buruli ulcer Campylobacter Cholera Cryptosporidiosis Cyclosporiasis Dracunculiasis (guinea-worm disease) Escherichia ...
https://en.wikipedia.org/wiki/List_of_pollution-related_diseases
BuruuliBuruuli
The Buruli ulcer (Articles lacking sources from February 2011, All articles lacking sources, Uganda articles missing ...
https://en.wikipedia.org/wiki/Buruuli
Tuberculosis in ChinaTuberculosis in China
... industry in China Tuberculosis-related 2007 tuberculosis scare Abreugraphy ATC code J04 Drugs for treatment of TB Buruli ulcer ...
https://en.wikipedia.org/wiki/Tuberculosis_in_China
Macrophage polarizationMacrophage polarization
... causing Buruli ulcer disease) and Mycobacterium avium. Improper and untimely control of M1 macrophage-mediated inflammatory ...
https://en.wikipedia.org/wiki/Macrophage_polarization
MAP InternationalMAP International
Buruli ulcer, Leprosy, Yaws, Lymphatic filariasis, Chagas Disease, Soil-transmitted Helminthes, and Rabies. Programs to ...
https://en.wikipedia.org/wiki/MAP_International
Dorothy Yeboah-ManuDorothy Yeboah-Manu
Health Organization Global Network of Laboratories Confirming Mycobacterium ulcerans Infection and the National Buruli Ulcer ...
https://en.wikipedia.org/wiki/Dorothy_Yeboah-Manu
List of skin conditionsList of skin conditions
Borderline lepromatous leprosy Borderline leprosy Borderline tuberculoid leprosy Buruli ulcer (Bairnsdale ulcer, Searl ulcer, ... Tropical ulcer (Aden ulcer, jungle rot, Malabar ulcer, tropical phagedena) Tularemia (deer fly fever, Ohara's disease, Pahvant ... Eosinophilic ulcer of the oral mucosa (eosinophilic ulcer of the tongue, Riga-Fede disease, traumatic eosinophilic granuloma) ... neurotrophic ulcer, perforating ulcer of the foot) Meralgia paresthetica (Roth-Bernhardt disease) Neurotic excoriations ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
ParatuberculosisParatuberculosis
... leaving ambiguous the appropriateness of the term to describe Buruli ulcer or Lady Windermere syndrome. The disease, discovered ...
https://en.wikipedia.org/wiki/Paratuberculosis
ANESVAD FoundationANESVAD Foundation
Buruli ulcer, HIV/AIDS in different countries. Besides projects in developing countries, ANESVAD provides public awareness and ...
https://en.wikipedia.org/wiki/ANESVAD_Foundation
Nontuberculous mycobacteriaNontuberculous mycobacteria
... and Buruli ulcer (caused by M. ulcerans or M. shinshuense). Post-traumatic abscesses most commonly occur after injection. ...
https://en.wikipedia.org/wiki/Nontuberculous_mycobacteria
Frank FennerFrank Fenner
... which causes Buruli ulcer, the third most important mycobacterial disease worldwide after tuberculosis and leprosy. Here he ...
https://en.wikipedia.org/wiki/Frank_Fenner
List of diseases (B)List of diseases (B)
Type 3 Burning mouth syndrome Buruli ulcer Buschke-Ollendorff syndrome Bustos-Simosa-Pinto-Cisternas syndrome Buttiens-Fryns ...
https://en.wikipedia.org/wiki/List_of_diseases_(B)
Global Initiative for Emergency and Essential Surgical CareGlobal Initiative for Emergency and Essential Surgical Care
A mycobacterial skin disease occurring primarily in children under 15 years old prompted the Buruli Ulcer program, which ... provided education on the treatment of the ulcers that result from the skin disease. Equipment for safe surgery, as well as ...
https://en.wikipedia.org/wiki/Global_Initiative_for_Emergency_and_Essential_Surgical_Care
Treatment | Buruli Ulcer | NCEZIDTreatment | Buruli Ulcer | NCEZID
... buruli ulcer signs and symptoms, buruli ulcer treatment, Buruli ulcer risks, Buruli ulcer disease, health care workers and ...
https://www.cdc.gov/buruli-ulcer/treatment.html
Browsing by Subject "Buruli Ulcer"
Buruli ulcer : a pocket guide for community health workers  World Health Organization. Global Buruli Ulcer Initiative (‎World ... Buruli ulcer  World Health Organization. Global Buruli Ulcer Initiative (‎World Health OrganizationWorld Health Organization, ... WHO Advisory Group on Buruli Ulcer. Meeting (‎4th: 2001: Geneva, Switzerland)‎; World Health Organization. Global Buruli Ulcer ... Buruli ulcer laboratory network and new external quality assessment programme for PCR-based diagnosis in the WHO African Region ...
https://apps.who.int:80/iris/browse?authority=Buruli+Ulcer&type=mesh
Buruli ulcerBuruli ulcer
Lulcere de buruli. Citation. World Health Organization. Global Buruli Ulcer Initiative. (‎2001)‎. Buruli ulcer. World Health ...
https://extranet.who.int/iris/restricted/handle/10665/67183
Buruli ulcer | WHO | Regional Office for AfricaBuruli ulcer | WHO | Regional Office for Africa
Buruli ulcer (BU), or Mycobacterium ulcerans disease, is a severe bacterial infection that affects the skin, soft tissues and ... Buruli ulcer).". Antibiotics. Different combination of antibiotics given for 8 weeks are used to treat the Buruli ulcer ... Buruli ulcer often starts as a painless swelling or nodule on the arms or legs. The nodules then develop into large ulcers, or ... Buruli ulcer is a chronic debilitating disease caused by Mycobacterium ulcerans.. *It often affects the skin and sometimes bone ...
https://www.afro.who.int/health-topics/buruli-ulcer
New tools for early diagnosis and decentralized treatment of Buruli ulcerNew tools for early diagnosis and decentralized treatment of Buruli ulcer
... which is characterized by skin ulcers that expand over extended periods, if not treated. The major burden of BU falls on ... Mycobacterium ulcerans is causing the chronic skin disease Buruli ulcer (BU) ... Mycobacterium ulcerans is causing the chronic skin disease Buruli ulcer (BU) which is characterized by skin ulcers that expand ... Tools4BU - New tools for early diagnosis and decentralized treatment of Buruli ulcer. ...
https://www.swisstph.ch/fr/projects/project-detail/project/new-tools-for-early-diagnosis-and-decentralized-treatment-of-buruli-ulcer
Arnaud Fontanet - Epidemiology of Buruli ulcer in Cameroon - Research - Institut PasteurArnaud Fontanet - Epidemiology of Buruli ulcer in Cameroon - Research - Institut Pasteur
Indeed, two studies of our group suggest that individuals sleeping under mosquito nets are at a lower risk of Buruli ulcer than ... and repellents are recommended for protection against Buruli ulcer, we seek to expand our initial studies by capturing insects ...
https://research.pasteur.fr/en/project/epidemiology-of-buruli-ulcer-in-cameroon/
Efforts to protect the Peninsula from the Buruli ulcer continue | Doherty Website
Cases of Buruli Ulcer have increased significantly in Victoria in recent years, particularly along the Mornington and Bellarine ... Efforts to protect the Peninsula from the Buruli ulcer continue. Mornington Peninsula Shire and the Peter Doherty Institute for ... Residents and visitors are reminded to protect themselves from possible sources of Buruli ulcer transmission by:. *Avoiding ... Research has shown areas where humans are most frequently contracting Buruli Ulcer are areas where possums and mosquitoes are ...
https://www.doherty.edu.au/news-events/news/efforts-to-protect-the-peninsula-from-the-buruli-ulcer-continue
Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer | CHIMIA Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer | CHIMIA
Buruli ulcer, Diverted total synthesis, Mycolactone, Total synthesis Abstract. Buruli ulcer, classified as a neglected tropical ... Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer Authors. * Sarah Saint- ...
https://chimia.ch/chimia/article/view/2017_836
Buruli Ulcer in Liberia, 2012Buruli Ulcer in Liberia, 2012
Confirmed Case of Buruli Ulcer, Senegal, 2018 Cite CITE. Title : Confirmed Case of Buruli Ulcer, Senegal, 2018 Personal Author( ... Buruli Ulcer/epidemiology Buruli Ulcer/history History, 21st Century Humans Mycobacterium Ulcerans ... Title : Buruli Ulcer in Liberia, 2012 Personal Author(s) : Kollie, Karsor;Amoako, Yaw Ampem;Ake, Julien;Mulbah, Tarnue;Zaizay, ... Buruli ulcer is a necrotizing skin disease caused by Mycobacterium ulcerans and is usually associated with tropical climates ...
https://stacks.cdc.gov/view/cdc/22106
Details for: Buruli ulcer : › WHO HQ Library catalog
Buruli ulcer -- complications , Rehabilitation , Buruli ulcer -- prevention and control , Communicable Diseases and their ... Buruli ulcer : a manual on how to prevent disability / Linda Lehman ... [et al.]. Contributor(s): Lehman, Linda , World Health ... Ulcère de Buruli : prévention des incapacités (POD) / éditeurs : Linda Lehman ... [et al.]Subject(s): ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-detail.pl?biblionumber=29833
Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer<...Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer<...
Buruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. The wounds of most BU patients are colonized with ... Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer. Nana Ama Amissah* ... Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer. In: PLoS Neglected ... Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer. PLoS Neglected ...
https://research.rug.nl/nl/publications/molecular-characterization-of-staphylococcus-aureus-isolates-tran
Buruli Ulcer | Africa Health OrganisationBuruli Ulcer | Africa Health Organisation
Buruli Ulcer. Buruli ulcer (BU), or Mycobacterium ulcerans disease, is a severe bacterial infection that affects the skin, soft ... Buruli ulcer often starts as a painless swelling or nodule on the arms or legs. The nodules then develop into large ulcers, or ...
https://aho.org/health-topics/buruli-ulcer/
Inventory of potential Buruli ulcer vectorsInventory of potential Buruli ulcer vectors
Inventory of Mycobacterium ulcerans occurrences in Buruli ulcer endemic areas in Benin.spections] ... Inventory of potential Buruli ulcer vectors Latest version published by Laboratory of Forest Sciences (University of Abomey- ... Buruli ulcer disease prevalence in Benin, West Africa: associations with land use / cover and the identification of disease ... AKOTON P T, KOURA K, GANGLO J (2020): Inventory of potential Buruli ulcer vectors. v1.5. Laboratory of Forest Sciences ( ...
https://ipt.gbifbenin.org/resource?r=perugine_dec_2020&v=1.5&request_locale=en
Figure - Correlation between Buruli Ulcer and Vector-borne Notifiable Diseases, Victoria, Australia - Volume 15, Number 4-April...
Buruli ulcer is shown on the right y axis, other diseases on the left y axis. RRV, Ross river virus; BFV, Barmah Forest virus; ... Correlation between Buruli Ulcer and Vector-borne Notifiable Diseases, Victoria, Australia Paul D.R. Johnson. and Caroline J. ... Correlation between Buruli Ulcer and Vector-borne Notifiable Diseases, Victoria, Australia. ...
https://wwwnc-origin.cdc.gov/eid/content/15/4/614-f1.htm
Figure 1 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging...
Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease M. Eric Benbow*1. , Heather Williamson†, Ryan Kimbirauskas*, ... Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease. ...
https://wwwnc-origin.cdc.gov/eid/content/14/8/1247-f1.htm
Search Results | AJTMHSearch Results | AJTMH
Buruli Ulcer Luz M. Moyano , Juan C. Chero , and Guillermo E. Gonzalvez ...
https://www.ajtmh.org/search?f_0=author&q_0=The+Cysticercosis+Working+Group+in+Peru
Buruli ulcer: training of health workers at national and districtBuruli ulcer: training of health workers at national and district
Buruli ulcer is a chronic debilitating disease *Mycobacterium ulcerans* that mainly affects the skin and sometimes bone. The ... Buruli ulcer is a chronic debilitating disease Mycobacterium ulcerans that mainly affects the skin and sometimes bone. The mode ... Overview: Buruli ulcer, caused by Mycobacterium ulcerans, is a chronic debilitating disease that affects mainly affects the ... By the end of this module, you will: explain the negative impact Buruli ulcer can have on patients and their families, the cost ...
https://openwho.org/courses/NTDs-buruli-ulcer
Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease) Unchanged | Cochrane AbstractsDrugs for treating Buruli ulcer (Mycobacterium ulcerans disease) Unchanged | Cochrane Abstracts
Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease) Unchanged answers are found in the Cochrane Abstracts powered ... ulcer__Mycobacterium_ulcerans_disease__Unchanged. Accessed 06 December 2022.. Drugs for treating Buruli ulcer (Mycobacterium ... Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease) Unchanged is a topic covered in the Cochrane Abstracts. To ... "Drugs for Treating Buruli Ulcer (Mycobacterium Ulcerans Disease) Unchanged." Cochrane Abstracts, Evidence Central, evidence. ...
https://evidence.unboundmedicine.com/evidence/view/Cochrane/435335/all/Drugs_for_treating_Buruli_ulcer__Mycobacterium_ulcerans_disease__Unchanged
Akonolinga - Buruli Ulcer Project Cameroon, 2002 - 2014 | MSF Intersectional Evaluation GroupAkonolinga - Buruli Ulcer Project Cameroon, 2002 - 2014 | MSF Intersectional Evaluation Group
A total of 1231 patients with ulcers, including 435 confirmed cases of BU, were diagnosed. They received institutional care, ...
https://evaluation.msf.org/evaluation-report/akonolinga-buruli-ulcer-project-cameroon-2002-2014
Table of Contents 2012 | Journal of Tropical Medicine | HindawiTable of Contents 2012 | Journal of Tropical Medicine | Hindawi
Buruli Ulcer: Treatment Challenges at Three Centres in Ghana. Pius Agbenorku , Isaac K. Donwi , ... , Paul Saunderson ...
https://www.hindawi.com/journals/jtm/contents/year/2012/
Disease progression and severe phenotype in tropical disease buruli ulcer | Cosmetic Skin DoctorDisease progression and severe phenotype in tropical disease buruli ulcer | Cosmetic Skin Doctor
Disease progression and severe phenotype in tropical disease buruli ulcer. Buruli ulcer is an infectious disease found in ...
http://www.cosmeticskindoctor.com/2015/09/10/disease-progression-and-severe-phenotype-in-tropical-disease-buruli-ulcer/
Psoriasis Diet - Dietary Dos and Donts for Psoriasis - Health Watch CenterPsoriasis Diet - Dietary Dos and Don'ts for Psoriasis - Health Watch Center
Various treatments such as application of topical creams and ointments, phototherapy and other systemic agents as well as an appropriate psoriasis diet can be implemented for effective management of the condition.. Psoriasis diet and lifestyle changes are thought to significantly impact outcomes of the disease, since this is a lifelong condition that currently has no definitive cure.. Vegetarian diets, lower energy diets, and certain dietary supplements as part of a psoriasis diet, as well as fasting periods are known to help relieve symptoms of the condition.. Obesity, alcohol consumption, smoking, exercise, stress and sleep disturbances are known to exacerbate psoriasis symptoms.. The fact is that there are no hard and fast rules as regards a psoriasis diet, except some general guidelines that can be tried in order to see what can work best for a given person.. ...
http://healthwatchcenter.com/2011/03/psoriasis-diet-dietary-dos-and-donts-for-psoriasis/
A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The BU-LABNET...A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The 'BU-LABNET...
Úlcera de Buruli; Mycobacterium ulcerans; Humanos; Úlcera de Buruli/diagnóstico; Úlcera de Buruli/epidemiologia; Úlcera de ... Buruli ulcer is one of the 20 neglected tropical diseases in the world. This necrotizing hypodermitis is a chronic debilitating ... Indeed, differential diagnosis are numerous and Buruli ulcer has varying clinical presentations. Up to now, the gold standard ... A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The "BU-LABNET ...
https://pesquisa.bvsalud.org/hansen/resource/pt/mdl-36331971
Infectious Diseases - Buruli/Bairnsdale ulcerInfectious Diseases - Buruli/Bairnsdale ulcer
... Associate Professor Daniel OBrien ...
https://www.barwonhealth.org.au/news/find-an-expert
CURED OF BURULI ULCERS - A MEDICAL MIRACLE IN KISMAYU - Ministry of Defence - KenyaCURED OF BURULI ULCERS - A MEDICAL MIRACLE IN KISMAYU - Ministry of Defence - Kenya
Ahmed Sahal was diagnosed with Buruli ulcers in 2018 when he was just nine years of age resulting to a complicated journey with ...
https://mod.go.ke/news-releases/cured-of-buruli-ulcers-a-medical-miracle-in-kismayu/
Search Results: Rash or multiple lesions, Madagascar
Buruli ulcer. 19. Crimean-Congo hemorrhagic fever. 4. Cutaneous amebiasis. 22. Cutaneous anthrax. ...
https://logicalimages.com/visualdx/differential/rash+or+multiple+lesions/madagascar?moduleId=100&findingId=25221,9812&reqFId=25221
Mycobacterium ulcerans: Trends in MicrobiologyMycobacterium ulcerans: Trends in Microbiology
Buruli ulcer, a prototype for ecosystem-related infection, caused by Mycobacterium ulcerans. ... Global epidemiology of Buruli ulcer, 2010-2017, and analysis of 2014 WHO programmatic targets. ... Mycolactone toxin induces an inflammatory response by targeting the IL-1beta pathway: mechanistic insight into Buruli ulcer ... Mycobacterium ulcerans is the etiological agent of Buruli ulcer, an emerging neglected tropical disease. This necrotizing ...
https://www.cell.com/trends/microbiology/fulltext/S0966-842X
LeprosyChagasNeglected tropicalRifampicinInfectionWorld Health OrganWest-AfricaBairnsdaleEpidemiology20012020Ulcerans2018MycobacterialDiagnosisDiseaseVictoriaNTDsPatientsHttpsSubtropicalGhanaCasesBeninHealthResearch
Leprosy7
  • Some common neglected tropical diseases are Buruli Ulcer, Dengue Fever and Hansen's disease (also known as leprosy). (medworm.com)
  • Including Mycobacterium ulcerans , a germ related to leprosy and tuberculosis, which causes the flesh-eating disease Buruli ulcer. (motherjones.com)
  • Diseases caused by mycobacteria include leprosy, tuberculosis (TB), nontuberculous mycobacteria (NTM) infections and Buruli Ulcer. (fda.gov)
  • Here, we review the diseases discussed at MHM8 and summarize the presentations on research advances in leprosy, NTM and Buruli Ulcer, human and animal TB, mycobacterial disease comorbidities, mycobacterial genetics and 'omics, and animal models. (fda.gov)
  • Professor Gavin Churchyard appointed Chair of the WHO/TDR Disease Reference Group for Tuberculosis, Leprosy and Buruli Ulcer. (auruminstitute.org)
  • Previous treatment of Buruli ulcer, tuberculosis or leprosy with at least one of the study drugs. (who.int)
  • Available at https://www.who.int/neglected_diseases/news/Leprosy-new-data-show-steady-decline-in-new-cases/en/ . (medscape.com)
Chagas2
  • He has extensive experience in development and introduction of diagnostics for neglected diseases, including HAT, leishmaniasis, Chagas disease, Buruli ulcer and schistosomiasis. (ilri.org)
  • Human African trypanosomiasis, Chagas disease, Buruli ulcer and many other conditions that cause death, disability and economic destitution for millions of people across the developing world don't attract the research effort their public health impact suggests they deserve. (pharmatimes.com)
Neglected tropical3
  • This introductory module gives an overview of the neglected tropical diseases (NTDs), skin-NTDs, and Buruli ulcer. (openwho.org)
  • Buruli ulcer is one of the 20 neglected tropical diseases in the world. (bvsalud.org)
  • It presents informations about neglected tropical diseases and brings details about the diseases such as blinding trachoma, buruli ulcer, cholera, dengue/dengue haemorrhagic fever, dracunculiasis (gui. (bvsalud.org)
Rifampicin3
  • Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. (cell.com)
  • Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy with Streptomycin and Rifampicin. (noguchimedres.org)
  • WHO BU Study - Randomized controlled trial comparing efficacy of 8 weeks treatment with Clarithromycin and Rifampicin versus streptomycin and Rifampicin for buruli ulcer (m. (studylib.net)
Infection7
  • The most proximal of the 3 ulcers had a diameter of associated with M. ulcerans infection. (cdc.gov)
  • Buruli ulcer (BU), or Mycobacterium ulcerans disease, is a severe bacterial infection that affects the skin, soft tissues and the bones. (who.int)
  • Mornington Peninsula Shire and the Peter Doherty Institute for Infection and Immunity (Doherty Institute), partners in the Beating Buruli in Victoria research project, are starting a trial of targeted mosquito control in the high-risk areas of Blairgowrie and Rye. (edu.au)
  • Buruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. (rug.nl)
  • Buruli ulcer, a prototype for ecosystem-related infection, caused by Mycobacterium ulcerans . (cell.com)
  • Consensus recommendations for the diagnosis, treatment and control of Mycobacterium ulcerans infection (Bairnsdale or Buruli ulcer) in Victoria, Australia. (austin.org.au)
  • Three cases of disease have emerged south of its usual catchment area in far-north QueenslandThe spread of a severe tissue-destroying ulcer once rare in Australia to a new geographic area in Queensland has infectious disease experts worried.The Buruli ulcer, also known as the Bairnsdale ulcer or Daintree ulcer, is an infection that eventually leads to an eruption of painful skin ulcers that fail to heal. (medworm.com)
World Health Organ1
  • Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases. (chimia.ch)
West-Africa1
  • Buruli ulcer is an infectious disease found in tropical regions of Africa, America, Asia, and Australia with West Africa as the main endemic area. (cosmeticskindoctor.com)
Bairnsdale1
  • Mycobacterium ulcerans causes slowly progressive, destructive skin and soft tissue infections, known as Bairnsdale or Buruli ulcer (BU). (austin.org.au)
Epidemiology2
  • The aim of the course is to provide information about Buruli ulcer, epidemiology, clinical presentation, diagnosis, treatment and public health measures to increase knowledge and skills of national programme managers and front-line health workers to address this disease. (openwho.org)
  • Global epidemiology of Buruli ulcer, 2010-2017, and analysis of 2014 WHO programmatic targets. (cell.com)
20011
20201
  • AKOTON P T, KOURA K, GANGLO J (2020): Inventory of potential Buruli ulcer vectors. (gbifbenin.org)
Ulcerans9
  • The highest bacterium ulcerans and is usually associated with tropical incidence of Buruli ulcer is found in tropical or subtropical climates and exposure to slow-moving or stagnant water. (cdc.gov)
  • Buruli ulcer, caused by Mycobacterium ulcerans is a chronic debilitating disease that affects mainly affects the skin and sometime bone. (who.int)
  • Buruli ulcer is a chronic debilitating disease caused by Mycobacterium ulcerans . (who.int)
  • Mycobacterium ulcerans is causing the chronic skin disease Buruli ulcer (BU) which is characterized by skin ulcers that expand over extended periods, if not treated. (swisstph.ch)
  • PLoS NTD, 2011), and repellents are recommended for protection against Buruli ulcer, we seek to expand our initial studies by capturing insects around houses and using PCR to search for M.ulcerans DNA in these insects. (pasteur.fr)
  • Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease) Unchanged is a topic covered in the Cochrane Abstracts . (unboundmedicine.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/435335/all/Drugs_for_treating_Buruli_ulcer__Mycobacterium_ulcerans_disease__Unchanged. (unboundmedicine.com)
  • Mycobacterium ulcerans is the etiological agent of Buruli ulcer, an emerging neglected tropical disease. (cell.com)
  • Background: Buruli ulcer (BU) is neglected skin disease caused by Mycobacterium ulcerans. (who.int)
20181
  • Ahmed Sahal was diagnosed with Buruli ulcers in 2018 when he was just nine years of age resulting to a complicated journey with the ailment. (go.ke)
Mycobacterial1
  • Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. (cell.com)
Diagnosis3
  • Biological confirmation of clinical diagnosis of Buruli ulcer is essential before starting chemotherapy . (bvsalud.org)
  • Indeed, differential diagnosis are numerous and Buruli ulcer has varying clinical presentations. (bvsalud.org)
  • Available at http://www.who.int/lep/diagnosis/en/ . (medscape.com)
Disease2
  • Buruli ulcer is a necrotizing skin disease caused by Myco- cial stigma on patients and their families ( 2,3 ). (cdc.gov)
  • Buruli ulcer has spread to town on Great Ocean Road and a suburb of GeelongThe spread to a new geographic area of Victoria of a severe tissue-destroying ulcer once rare in Australia has caused health authorities to issue a state-wide health alert to doctors.The Buruli ulcer occurs in very specific areas of Victoria and Queensland, and those who don 't enter an endemic area don't get the disease. (medworm.com)
Victoria1
  • Cases of Buruli Ulcer have increased significantly in Victoria in recent years, particularly along the Mornington and Bellarine Peninsulas. (edu.au)
NTDs1
  • By the end of this module, you will: explain general information related to NTDs, skin NTDs and a historical overview of Buruli ulcer. (openwho.org)
Patients4
  • By the end of this module, you will: explain the negative impact Buruli ulcer can have on patients and their families, the cost of treatment, disability, and stigma associated with it. (openwho.org)
  • A total of 1231 patients with ulcers, including 435 confirmed cases of BU, were diagnosed. (msf.org)
  • Cette étude avait pour objectif de décrire le profil épidémiologique, clinique, et thérapeutique des patients ayant une fasciite nécrosante dans un service de chirurgie plastique en milieu tropical. (bvsalud.org)
  • Les lésions ont intéressé en général des patients de sexe féminin avec un âge moyen de 47ans. (bvsalud.org)
Https1
  • Available at https://apps.who.int/medicinedocs/en/d/Js5511e/3.3.html . (medscape.com)
Subtropical1
  • At least 33 countries with tropical, subtropical and temperate climates have reported Buruli ulcer in Africa, South America and Western Pacific regions. (who.int)
Ghana1
  • Enhancing Buruli ulcer control in Ghana through social interventions: a case study from the Obom sub-district. (noguchimedres.org)
Cases4
  • sub-Saharan Africa, but 2 cases have been reported in Mali, We report a case of Buruli ulcer that may have originated in an urban semiarid area of Senegal. (cdc.gov)
  • By the end of this module, you will: recall surveillance definitions, forms used to record and report Buruli ulcer cases, key indicators, and how to analyze and report on data. (openwho.org)
  • As Buruli ulcer cases have risen, they have taken a physical and psychological toll but also offered hope that scientists can solve the bacteria 's many mysteries. (medworm.com)
  • Currently, advanced cases of Buruli ulcer can only be cured by surgical excision or amputation. (motherjones.com)
Benin1
  • Centre de Diagnostic et de Traitement de la lèpre et de l'Ulcère de Buruli (CDTLUB)/Raoul et Madeleine Follereau, Pobè, Benin. (bvsalud.org)
Health3
  • To learn more about the project or about the Buruli Ulcer visit www2.health.vic.gov.au/beatingburuli . (edu.au)
  • This course is intended to provide basic information for front-line health workers to be able to implement the recommended control measures to minimize the negative impact of Buruli ulcer on populations. (openwho.org)
  • You will also describe the public health measures aimed at reducing the impact of Buruli ulcer populations. (openwho.org)
Research1
  • Research has shown areas where humans are most frequently contracting Buruli Ulcer are areas where possums and mosquitoes are most frequently carrying the causative bacteria. (edu.au)
Buruli Ulcer, Nigeria - Volume 13, Number 5-May 2007 - Emerging Infectious Diseases journal - CDC
Buruli Ulcer, Nigeria - Volume 13, Number 5-May 2007 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Figure - Buruli Ulcer, Nigeria - Volume 13, Number 5-May 2007 - Emerging Infectious Diseases journal - CDC
Figure - Buruli Ulcer, Nigeria - Volume 13, Number 5-May 2007 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Figure - Buruli Ulcer, Central African Republic - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC
Figure - Buruli Ulcer, Central African Republic - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Buruli Ulcer, Central African Republic - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC
Buruli Ulcer, Central African Republic - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Browsing by Subject Buruli Ulcer
Browsing by Subject "Buruli Ulcer" (apps.who.int:80)
Buruli ulcer : recognize act now
Buruli ulcer : recognize act now (apps.who.int)
Appendix Figure 1 - Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious...
Appendix Figure 1 - Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious... (wwwnc.cdc.gov)
Appendix Figure 2 - Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious...
Appendix Figure 2 - Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious... (wwwnc.cdc.gov)
Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious Diseases journal - CDC
Buruli Ulcer Surveillance, Benin, 2003-2005 - Volume 13, Number 9-September 2007 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Appendix - Buruli Ulcer Prevalence and Altitude, Benin - Volume 17, Number 1-January 2011 - Emerging Infectious Diseases...
Appendix - Buruli Ulcer Prevalence and Altitude, Benin - Volume 17, Number 1-January 2011 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Search
Search (apps.who.int)
Figure - Buruli Ulcer in Long-Term Traveler to Senegal - Volume 15, Number 1-January 2009 - Emerging Infectious Diseases...
Figure - Buruli Ulcer in Long-Term Traveler to Senegal - Volume 15, Number 1-January 2009 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Buruli Ulcer in Long-Term Traveler to Senegal - Volume 15, Number 1-January 2009 - Emerging Infectious Diseases journal - CDC
Buruli Ulcer in Long-Term Traveler to Senegal - Volume 15, Number 1-January 2009 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Search Results | AJTMH
Search Results | AJTMH (ajtmh.org)
Figure 2 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging...
Figure 2 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging... (wwwnc.cdc.gov)
Figure 4 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging...
Figure 4 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging... (wwwnc.cdc.gov)
Figure 3 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging...
Figure 3 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging... (wwwnc.cdc.gov)
Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging Infectious...
Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging Infectious... (wwwnc.cdc.gov)
Figure 1 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging...
Figure 1 - Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease - Volume 14, Number 8-August 2008 - Emerging... (wwwnc.cdc.gov)
Buruli ulcer
Buruli ulcer (extranet.who.int)
العربية
العربية (extranet.who.int)
Buruli ulcer
Buruli ulcer (extranet.who.int)
Figure 1 - Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging...
Figure 1 - Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging... (wwwnc.cdc.gov)
Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging Infectious...
Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging Infectious... (wwwnc.cdc.gov)
Figure 2 - Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging...
Figure 2 - Buruli Ulcer in United Kingdom Tourist Returning from Latin America - Volume 15, Number 11-November 2009 - Emerging... (wwwnc.cdc.gov)
Figure 3 - Buruli Ulcer in Ghana: Results of a National Case Search - Volume 8, Number 2-February 2002 - Emerging Infectious...
Figure 3 - Buruli Ulcer in Ghana: Results of a National Case Search - Volume 8, Number 2-February 2002 - Emerging Infectious... (wwwnc.cdc.gov)