A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.
A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.
A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
The parts of the gene sequence that carry out the different functions of the GENES.
A hardy grain crop, rye, grown in northern climates. It is the most frequent host to ergot (CLAVICEPS), the toxic fungus. Its hybrid with TRITICUM is TRITICALE, another grain.
An order of heavy-bodied, largely terrestrial BIRDS including pheasants, TURKEYS, grouse, QUAIL, and CHICKENS.
The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.
A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).
April 25th -26th, 1986 nuclear power accident that occurred at Chernobyl in the former USSR (Ukraine) located 80 miles north of Kiev.
The region in the hindlimb of a quadruped, corresponding to the human ANKLE.
Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
An independent administrative agency concerned with maintaining competitive free enterprise by prohibiting unfair methods of competition and unfair deceptive acts or practices.
The state of legal insolvency with assets taken over by judicial process so that they may be distributed among creditors.
Those federal and state laws, and their enforcement, that protect trade and commerce from unlawful restraints and monopolies or unfair business practices.
Viscous materials composed of complex, high-molecular-weight compounds derived from the distillation of petroleum or the destructive distillation of wood or coal. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Cooperation among hospitals for the purpose of sharing various departmental services, e.g., pharmacy, laundry, data processing, etc.
The rose plant family in the order ROSALES and class Magnoliopsida. They are generally woody plants. A number of the species of this family contain cyanogenic compounds.
A plant genus of the family Musaceae, order Zingiberales, subclass Zingiberidae, class Liliopsida.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
Time period from 1601 through 1700 of the common era.
Hearing loss due to damage or impairment of both the conductive elements (HEARING LOSS, CONDUCTIVE) and the sensorineural elements (HEARING LOSS, SENSORINEURAL) of the ear.
Time period from 1701 through 1800 of the common era.
Time period from 1801 through 1900 of the common era.
A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.
Time period from 1901 through 2000 of the common era.
Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulation and other movements. It is classified as Thomsen (autosomal dominant) or Becker (autosomal recessive) generalized myotonia mainly based on the inheritance pattern. Becker type is also clinically more severe. An autosomal dominant variant with milder symptoms and later onset is known as myotonia levior. Mutations in the voltage-dependent skeletal muscle chloride channel are associated with the disorders.
Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-expression of SOX9 TRANSCRIPTION FACTOR gene on chromosome 17q and its surrounding region is associated with the syndrome.
Games in which players use a racquet to hit a ball or similar type object.
Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities.
Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".
Educational institutions.
A competitive team sport played on a rectangular field. This is the American or Canadian version of the game and also includes the form known as rugby. It does not include non-North American football (= SOCCER).
Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.
A game in which a round inflated ball is advanced by kicking or propelling with any part of the body except the hands or arms. The object of the game is to place the ball in opposite goals.

Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. (1/1867)

Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem.  (+info)

Effects of clonidine on myocardial beta-adrenergic receptor-adenyl cyclase-cAMP system after scalds in rats. (2/1867)

AIM: To study the role of clonidine (Clo) on the myocardial beta-adrenergic receptor (beta-AR)-adenyl cyclase (AC)-cAMP system after the scalds in rats. METHODS: A 30% skin-full-thickness scald was produced by immersing rats in 95 degrees C water for 9 s. Clo 0.1-3.0 mg.kg-1 was injected i.p. to rats at 30 min before scalds, yohimbine (Yoh) 0.05 mg.kg-1 or prazosin (Pra) 0.03 mg.kg-1 to rats at 30 min before i.p. Clo. beta-AR density and affinity, AC activity, phosphoric diester hydrolases (PDH) activity, and cAMP content were determined with radioreceptor assay, indirect method, enzymeradiochemical assay, and radioimmunoassay, respectively. RESULTS: Clo inhibited the decrease of the myocardial beta-AR density, the attenuation of AC activity, and the reduction of cAMP content at 12 h after the scalds. Yoh partially reversed the effects of Clo on the three parameters. But Pra did not. CONCLUSION: Clo reversed the changes of the myocardial beta-AR-AC-cAMP system resulted from the scalds in rats.  (+info)

The thermal sensitivity of the polymodal nociceptors in the monkey. (3/1867)

1. The static and dynamic sensitivities to thermal and mechanical stimuli of polymodal nociceptors in hairy skin of the anaesthetized monkey have been investigated by recording activity in their primary nerve fibres. 2. Polymodal nociceptors responded to skin pricking, pinching and heating to temperatures higher than 40 degrees C. They did not respond to touch, stretch or cold. The conduction velocity of their axons was from 0.6 to 1.1 m/sec. 3. Three types of cutaneous receptive fields have been observed: single spot-like areas of 1-2 mm2; multiple spot-like areas of 1-2 mm2; and larger areas up to 25 mm2 with heterogeneous sensitivity. 4. Polymodal nociceptors were subjected to heat stimuli that commenced from a 33 or 37 degrees C adapting temperature. A series consisted of heating their receptive fields to 43, 45, 47 and 50 degrees C from one or the other adapting temperatures at a constant rate of 0.2 degrees C/sec. Each heat stimulus intensity was maintained for 4 min after which the skin was returned to the adapting temperature. Immediately after the first series the identical series was repeated in order to determine the effect of prior heating upon the dynamic responses to re-heating. The dynamic responses were characterized by three phases: an initiation of a discharge at a threshold level of skin temperature; a dynamic discharge during the suprathreshold change, that reached a peak frequency when the temperature reached its maximum; and an adaptation phase while the temperature remained at the high intensity. Adaptation was rapid initially, and then slowed during the final minutes at the high intensity. 5. Adapting the receptive field to either 33 degrees C or to 37 degrees C before the heat stimuli did not affect the sensitivity and the discharge pattern of the polymodal nocicpetors. 6. During the first series of stimulations, the threshold at which the individual polymodal nociceptors began to discharge to heat stimuli varied from 40 to 46.5 degrees C. The mean threshold of the population was 42.5 degrees C. 7. No change in the threshold was observed when responses to 0.2 and 1.5 degrees C/sec rates of heating were compared...  (+info)

Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism. (4/1867)

In response to cutaneous injury, expression of collagenase-1 is induced in keratinocytes via alpha2beta1 contact with native type I collagen, and enzyme activity is essential for cell migration over this substratum. However, the cellular mechanism(s) mediating integrin signaling remain poorly understood. We demonstrate here that treatment of keratinocytes cultured on type I collagen with epidermal growth factor receptor (EGFR) blocking antibodies or a specific receptor antagonist inhibited cell migration across type I collagen and the matrix-directed stimulation of collagenase-1 production. Additionally, stimulation of collagenase-1 expression by hepatocyte growth factor, transforming growth factor-beta1, and interferon-gamma was blocked by EGFR inhibitors, suggesting a required EGFR autocrine signaling step for enzyme expression. Collagenase-1 mRNA was not detectable in keratinocytes isolated immediately from normal skin, but increased progressively following 2 h of contact with collagen. In contrast, EGFR mRNA was expressed at high steady-state levels in keratinocytes isolated immediately from intact skin but was absent following 2 h cell contact with collagen, suggesting down-regulation following receptor activation. Indeed, tyrosine phosphorylation of the EGFR was evident as early as 10 min following cell contact with collagen. Treatment of keratinocytes cultured on collagen with EGFR antagonist or heparin-binding (HB)-EGF neutralizing antibodies dramatically inhibited the sustained expression (6-24 h) of collagenase-1 mRNA, whereas initial induction by collagen alone (2 h) was unaffected. Finally, expression of collagenase-1 in ex vivo wounded skin and re-epithelialization of partial thickness porcine burn wounds was blocked following treatment with EGFR inhibitors. These results demonstrate that keratinocyte contact with type I collagen is sufficient to induce collagenase-1 expression, whereas sustained enzyme production requires autocrine EGFR activation by HB-EGF as an obligatory intermediate step, thereby maintaining collagenase-1-dependent migration during the re-epithelialization of epidermal wounds.  (+info)

Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. (5/1867)

The effects of a monoclonal antibody against L-selectin [leukocyte adhesion molecule (LAM)1-3] on microvascular fluid flux were determined in conscious sheep subjected to a combined injury of 40% third-degree burn and smoke inhalation. This combined injury induced a rapid increase in systemic prefemoral lymph flow (sQlymph) from the burned area and a delayed-onset increase in lung lymph flow. The initial increase in sQlymph was associated with an elevation of the lymph-to-plasma oncotic pressure ratio; consequently, it leads to a predominant increase in the systemic soft tissue permeability index (sPI). In an untreated control group, the increased sPI was sustained beyond 24 h after injury. Pretreatment with LAM1-3 resulted in earlier recovery from the increased sPI, although the initial responses in sQlymph and sPI were identical to those in the nontreatment group. The delayed-onset lung permeability changes were significantly attenuated by pretreatment with LAM1-3. These findings indicate that both leukocyte-dependent and -independent mechanisms are involved in the pathogenesis that occurs after combined injury with burn and smoke inhalation.  (+info)

Insulin but not growth hormone stimulates protein anabolism in skin wound and muscle. (6/1867)

We have measured protein kinetics in the scalded skin and normal muscle in anesthetized rabbits. On the 7th day after ear scald, L-[ring-13C6]phenylalanine was infused as a tracer, and the ear and hindlimb were used as arteriovenous units to reflect skin and muscle protein kinetics. Insulin was infused at 0.6 or 2.3-3.4 mU. kg-1. min-1 in the low-dose and high-dose insulin groups. In the growth hormone group, recombinant human growth hormone was administered at 2 mg. kg-1. day-1 after the ear was scalded. The results were compared with a control group in which the ear was scalded but otherwise was not treated. In the control group, net protein loss in the scalded skin and muscle was 23.1 +/- 21.4 and 3.9 +/- 1.5 micromol. 100 g-1. h-1, respectively. Insulin infusion at either high or low dose reduced net protein loss to near zero by inhibiting proteolysis. In contrast, growth hormone treatment had no anabolic effect on either tissue. In conclusion, insulin but not growth hormone has an anabolic effect on scalded skin and normal muscle; low-dose insulin is as effective in achieving an anabolic effect on both tissues, with less hypoglycemic response than high-dose insulin.  (+info)

Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands. (7/1867)

OBJECTIVE: To document long-term results associated with an coordinated plan of care for acutely burned hands in children. SUMMARY AND BACKGROUND DATA: Optimal hand function is a crucial component of a high-quality survival after burn injury. This can be achieved only with a coordinated approach to the injuries. Long-term outcomes associated with such a plan of care have not been previously reported. METHODS: Over a 10-year period, 495 children with 698 acutely burned hands were managed at a regional pediatric burn facility; 219 children with 395 injured hands were followed in the authors' outpatient clinic for at least 1 year and an average of >5 years. The authors' approach to the acutely burned hand emphasizes ranging and splinting throughout the hospital stay, prompt sheet autograft wound closure as soon as practical, and the selective use of axial pin fixation and flaps. Long-term follow-up, hand therapy, and reconstructive surgery are emphasized. RESULTS: Normal functional results were seen in 97% of second-degree and 85% of third-degree injuries; in children with burns involving underlying tendon and bone, 70% could perform activities of daily living and 20% had normal function. Reconstructive hand surgery was required in 4.4% of second-degree burns, 32% of third-degree burns, and 65% of those with injuries involving underlying bone and tendon. CONCLUSIONS: When managed in a coordinated long-term program, the large majority of children with serious hand burns can be expected to have excellent functional results.  (+info)

Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment. (8/1867)

OBJECTIVE: To determine the effects of recombinant human insulin-like growth factor-1 (IGF-1) complexed with its principal binding protein, IGFBP-3, on skeletal muscle metabolism in severely burned children. SUMMARY BACKGROUND DATA: Severe burns are associated with a persistent hypermetabolic response characterized by hyperdynamic circulation and severe muscle catabolism and wasting. Previous studies showed that nutritional support and pharmacologic intervention with anabolic agents such as growth hormone and insulin abrogated muscle wasting and improved net protein synthesis in the severely burned. The use of these agents, however, has several adverse side effects. A new combination of IGF-1 and IGFBP-3 is now available for clinical study. METHODS: Twenty-nine severely burned children were prospectively studied before and after treatment with 0.5, 1, 2, or 4 mg/kg/day IGF-1/IGFBP-3 to determine net balance of protein across the leg, muscle protein fractional synthetic rates, and glucose metabolism. Another group was studied in a similar fashion without IGF-1/IGFBP-3 treatment as time controls. RESULTS: Seventeen of 29 children were catabolic before starting treatment. The infusion of 1.0 mg/kg/day IGF-1/IGFBP-3 increased serum IGF-1, which did not further increase with 2.0 and 4.0 mg/kg/day. IGF-1/IGFBP-3 treatment at 1 to 4 mg/ kg/day improved net protein balance and increased muscle protein fractional synthetic rates. This effect was more pronounced in catabolic children. IGF-1/IGFBP-3 did not affect glucose uptake across the leg or change substrate utilization. CONCLUSIONS: IGF-1/IGFBP-3 at doses of 1 to 4 mg/kg/day attenuates catabolism in catabolic burned children with negligible clinical side effects.  (+info)

Tue Sep 1, 2020 , By: Law Firm of Walter Gabriel , General , Share. Severe burn injuries can be catastrophic not just for the body but for the mind, too. Theyre incredibly painful and often leave scarring, even disfigurement, that affect survivors quality of life and self-esteem. Injuries are often so critical that some survivors may not fully recover.. Luckily, scientists have developed treatments that heal deep burns and restore normalcy in burn victims lives. One of the most common treatments is skin grafting, a procedure that removes skin from one part of the body and transplants it into the affected area. This is a popular way to treat severe burns and other conditions or injuries that have caused the patient to lose an area of protective skin.. Here is our quick guide to skin grafting and how it helps treat severe burn injuries:. Two Kinds of Skin Grafts. Skin grafts come in two different procedures to treat a variety of deep burns. The first one is the split-thickness skin graft. This ...
TY - JOUR. T1 - Outcomes of early use of an end of range axilla orthotic in children following burn injury. AU - Thomas, Rhianydd. AU - Wicks, Stephanie. AU - Toose, Claire. AU - Pacey, Verity. PY - 2019/8/14. Y1 - 2019/8/14. N2 - Scar contracture is a significant complication of burn injury. This study aimed to describe outcomes of early axilla orthotic use at end of range abduction in children, following a burn to the axilla region. A retrospective review of 76 children (mean age 3.9 years [SD 3.6]) treated at a tertiary childrens hospital from 2006 to 2016 was conducted. No child developed axilla contracture for the duration of the 2-year study follow-up with no adverse events recorded. If orthotic use was ceased ,60 days post-burn, it was considered not an essential intervention to maintain range of movement, leaving 49 children using the orthotic ≥60 days. Compared with the children who ceased orthotic use in ,60 days, children who required the orthotic ≥60 days had a significantly ...
TY - JOUR. T1 - Raoultella planticola bacteremia-induced fatal septic shock following burn injury. AU - Yumoto, Tetsuya. AU - Naito, Hiromichi. AU - Ihoriya, Hiromi. AU - Tsukahara, Kohei. AU - Ota, Tomoyuki. AU - Watanabe, Toshiyuki. AU - Nakao, Atsunori. N1 - Publisher Copyright: © 2018 The Author(s). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2018/5/4. Y1 - 2018/5/4. N2 - Background: Raoultella planticola, a Gram-negative, aerobic bacillus commonly isolated from soil and water, rarely causes invasive infections in humans. Septic shock from R. planticola after burn injury has not been previously reported. Case presentation: A 79-year-old male was admitted to the emergency intensive care unit after extensive flame burn injury. He accidently caught fire while burning trash and plunged into a nearby tank filled with contaminated rainwater to extinguish the fire. The patient developed septic shock on day 10. The blood culture detected R. planticola, which was identified ...
Glucocorticoids (GC) are steroid hormones that modulate T cell functions and restrain their hyperresponsiveness following stimulation. Naive T lymphocytes are sensitive to GC but become more resistant when they are activated. A balance between activation and inhibition signals is important for a targeted and effective T cell response. Thermal injury is characterized by an immune dysfunction and hyperactive T cells visible at day 10 postburn. In this study, our objective was to evaluate T cell sensitivity to GC following thermal injury and to identify mechanisms that could modulate their sensitivity. One mechanism that we hypothesized was increased p38 mitogen-activated protein kinase (MAPK) activity that could lead to GC resistance. Male C57BL/6 mice underwent a full-thickness 20% total body surface area. At 10 days postinjury, splenic T cells were isolated. Glucocorticoid receptor (GR) expression was higher in T cells from burn-injured mice. Interestingly, these cells were also less sensitive to GC
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Objective: The immune response to an inflammatory stimulus is balanced and or-chestrated by stimulatory and inhibitory factors. After a thermal trauma, this balance is disturbed and an excessive immune reaction with increased production and release of proinflammatory cytokines results. The nicotine-stimulated anti-inflammatory reflex offsets this. The goal of this study was to verify that transdermal administration of nico-tine downregulates proinflammatory cytokine release after burn trauma. Methods: A 30 % total body surface area full-thickness rat burn model was used in Sprague Dawley rats (n = 35, male). The experimental animals were divided into a control group, a burn trauma group, a burn trauma group with additional nicotine treatment, and a sham + nicotine group with 5 experimental animals per group. The last 2 groups received a transdermal nicotine administration of 1.75 mg. The concentrations of tumor necrosis factor
Rational: Androgens have been known to inhibit cutaneous (non-burn) wound repair in men and male mice by exacerbating wound inflammation and modifying re-epithelialization. However, recent studies have reported that in severe burn injury (over 20% TBSA), androgen treated patients better maintain lean body mass, have improved hypermetabolic response and shorter healing time. This highlights a contradictory and context-dependent role of androgens in the wound healing of burn injury and simple incisional skin wound healing.. Objective:The aim of this study was to identify the role of androgens in severe burn injury wound healing, in particular whether androgens target local healing processes or systemic burn induced hypermetabolic state.. Methods: Mice were subjected to a thermal injury from a hot brass rod (4cm²) constituting a severe large burn. After 48 hrs following thermal injury, the wound site was debrided to remove damaged skin and to avoid infection prior to wound dressing. Mice were ...
Pain management is one of the most important aspects of burn care. Procedural pain protocols require continuous revision and reassessment to ensure optimal pain management is being provided to burn patients.15 This investigation aimed to determine if relationships existed between patient and clinical characteristics, and pain at first dressing change for children with acute burn injuries. Findings from this investigation serve as an alert for healthcare professionals to factors associated with moderate to severe pain in pediatric burn patients during their first dressing change. The identification of children with clinical characteristics associated with increased pain allows for pre-emptive implementation of pharmacological and non-pharmacological interventions for pain reduction, and the development of individualized treatment plans for these patients. Preventing the onset of severe procedural pain is the current goal-as opposed to controlling and reducing severe pain following its onset (ie, ...
Definition of partial thickness burn in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is partial thickness burn? Meaning of partial thickness burn as a legal term. What does partial thickness burn mean in law?
There remains worldwide variation in the surgical management of major deep or full thickness burns in both adult and paediatric patients. In our burn service over the past two decades the standard of care has been to perform total or near-total excision of full thickness burns in all patients within 24 hours of the patients injury or admission to the Burns Service.. Early wound excision improves survival, decreases burn wound sepsis, shortens length of stay and provides better aesthetic and functional outcomes when compared to serial excision and grafting or conservative non-surgical debridement using topical agents. Retrospective studies, comparative randomised controlled trials and meta-analysis studies have confirmed the benefits of this approach.. Data was presented on this approach to major burn injury in our service at ANZBA in 2009. We have continued to collect data and analyse the effect of early total or near total surgical excision in major burn injury over the past two ...
TY - JOUR. T1 - Calcium and ER stress mediate hepatic apoptosis after burn injury. AU - Jeschke, Marc G.. AU - Gauglitz, Gerd G.. AU - Song, Juquan. AU - Kulp, Gabriela A.. AU - Finnerty, Celeste C.. AU - Cox, Robert A.. AU - Barral, José M.. AU - Herndon, David N.. AU - Boehning, Darren. PY - 2009/8. Y1 - 2009/8. N2 - A hallmark of the disease state following severe burn injury is decreased liver function, which results in gross metabolic derangements that compromise patient survival. The underlying mechanisms leading to hepatocyte dysfunction after burn are essentially unknown. The aim of the present study was to determine the underlying mechanisms leading to hepatocyte dysfunction and apoptosis after burn. Rats were randomized to either control (no burn) or burn (60% total body surface area burn) and sacrificed at various time-points. Liver was either perfused to isolate primary rat hepatocytes, which were used for in vitro calcium imaging, or liver was harvested and processed for ...
Intubation of burn-injured patients, especially combined with interhospital transport, is not a benign intervention. In response to the death of a burn-injured patient from complications of intubation subsequently judged to not to be indicated, the Parkland Hospital burn staff performed a retrospective review of the hospital course of burn patients intubated before transport to their emergency department.23 A large number of these patients were extubated the same or the next day, suggesting that intubation was not indicated in these patients. Thus, they were exposed to risk without commensurate benefit. Out of concern for exacerbation of a thermal laryngeal injury, otolaryngologists at the Baltimore Regional Trauma Center performed a prospective study of patients presenting to their emergency department with risk factors for inhalation injury.24 If patients at risk were not in respiratory distress and did not have other indications for immediate intubation such as large full-thickness burns, ...
TY - JOUR. T1 - Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children. AU - Kraft, Robert. AU - Herndon, David N.. AU - Finnerty, Celeste C.. AU - Hiyama, Yaeko. AU - Jeschke, Marc G.. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Context: Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear. Objective: The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses. Design and Setting: We conducted a prospective cohort study at an academic pediatric hospital burn center. Patients: Our study included 219 pediatric burn patients. Main Outcome Measures: Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed. Results: All groups were ...
Proven microbial species in burn wounds: Initially Escherichia coli, Pseudomonas putida, Enteroccus faecalis, MSSA, Enterobacter cloacae and Candida tropicalis. Later on positive cultures with Serratia marcescens and Citrobacter freundii (tracheal secretion MSSA and Serratia liquefaciens). Late positive cultures with Trichosporon mucoides or mucormycosis (sensitive to voriconazole and amphotericine B). Proven sepsis with positive blood cultures (MSSA, Candida tropicalis ...
Costantini TW, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: A cholinergic agonist prevents gut barrier failure after severe burn injury. Am J Pathol 2012 Aug;181(2):478-86. Epub 2012 Jun 8.. Costantini TW, Bansal V, Krzyzaniak MJ, Putnam JG, Peterson CY, Loomis WH, Wolf PL, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol 2010 Dec;299(6):G1308-18. Epub 2010 Aug 12.. Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. Vagal Nerve Stimulation Blocks Peritoneal Macrophage Inflammatory Responsiveness After Severe Burn Injury. Shock 2012 Aug;38(3):294-300. PMCID: PMC3422402.. Krzyzaniak MJ, Peterson CY, Cheadle G, Loomis W, Wolf P, Kennedy V, Putnam JG, Bansal V, Eliceiri B, Baird A, Coimbra R. Efferent vagal ...
The U.S. Consumer Product Safety Commission is charged with protecting the public from unreasonable risks of injury or death associated with the use of thousands of types of consumer products under the agencys jurisdiction. Deaths, injuries, and property damage from consumer product incidents cost the nation more than $1 trillion annually. CPSC is committed to protecting consumers and families from products that pose a fire, electrical, chemical or mechanical hazard. CPSCs work to help ensure the safety of consumer products - such as toys, cribs, power tools, cigarette lighters and household chemicals -- contributed to a decline in the rate of deaths and injuries associated with consumer products over the past 40 years.. Federal law bars any person from selling products subject to a publicly-announced voluntary recall by a manufacturer or a mandatory recall ordered by the Commission.. To report a dangerous product or a product-related injury go online to www.SaferProducts.gov or call CPSCs ...
2 Answers - Posted in: skin, recovery, scar - Answer: Hi, last year, i spilled boiling water on to my hand. I lost all the skin ...
TY - JOUR. T1 - Small-volume resuscitation using hypertonic saline improves organ perfusion in burned rats. AU - Kien, Nguyen D.. AU - Antognini, Joseph F.. AU - Reilly, Debra A.. AU - Moore, Peter G.. PY - 1996. Y1 - 1996. N2 - Resuscitation using small volumes (3-5 mL/kg) of 7.5% hypertonic saline (HTS) is effective for hemorrhagic shock. Whether HTS is beneficial for the initial resuscitation of burn injury is not clear. We compared the hemodynamic effects of HTS versus lactated Ringers solution (LR) and examined organ tissue perfusion during burn resuscitation (R). Full thickness scald burn (35% of total body surface area) was induced in pentobarbital- anesthetized rats. Regional blood flows were measured using radioactive microspheres before and 30 min after burn, and after R with either HTS (4 mL/kg) or LR (at a dose required for equivalent restoration of arterial blood pressure). Data from the HTS-or LR-resuscitated groups were compared to those from a nonresuscitated group (n = 10 in ...
Psychological trauma is an unfortunate and common occurrence after a burn injury. Trauma suffered by burn injury survivors often lurks far beneath physical disfigurement. Insidious and unseen, the attendant social and psychological consequences can often be more damaging than the burn injury itself. Understanding what these symptoms are, and how they manifest themselves, can lead to successful treatment options.. Severe burn injuries are a major source of stress for everyone involved in the burn survivors life. Primary causes of stress include: pain and/or itching during the healing process, reliving the event and the circumstances that caused the burn injury, changes in appearance and the reaction of others to these changes, and worries about the future concerning all of these issues. Psychological stress affects all mind and body functions, and can trigger other medical complications.. Theres a litany of normal physical and emotional reactions to an abnormal event, such as a burn injury. ...
UC Davis burn specialist David Greenhalgh noted that while past research had successfully focused on enabling patients to survive severe burns, improving a victims quality of life after a burn injury remained a major challenge. It is the reason why collecting and managing data about burn victims is now so important.. The coordinating center at UC Davis will be much more than just a simple repository of data, said Greenhalgh, a professor of surgery and past president of the American Burn Association. We will be overseeing the safety of the clinical trials at all research sites to ensure there is uniformity in the way they are being conducted. By having this type of rigorous infrastructure in place, we ultimately can develop the best treatment plans for burn patients.. Most burn injuries occur in young people aged 20-40 years, and severe burn injuries represent one of the leading causes of lost work-years in the United States. Twenty years ago, burns that involved half the body surface area ...
Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we are lacking data on burn shock. Our objective was to assess the hydrocortisone-induced transcriptional modulation in severe burn shock, particularly modulation of the immune response. We collected whole blood samples during a randomized controlled trial assessing the efficacy of hydrocortisone administration in burn shock. Using whole genome microarrays, we first compared burn patients (n = 32) from the placebo group to healthy volunteers to describe the transcriptional modulation induced by burn shock over the first week. Then we compared burn patients randomized for either hydrocortisone administration or placebo, to assess hydrocortisone-induced modulation. Study groups were similar in terms of severity and major outcomes, but shock duration was significantly
Subjects presenting within 6 hours of a severe thermal injury, defined as greater than 20% of their total body surface area, or their family members will be approached on admission to Parkland Memorial Hospital and informed of the study. Those electing to participate in the study will be randomized to receive either high-dose vitamin C (66mg/kg/hr for the first 24 hours, this dosage is based on prior human studies) in addition to the standard resuscitation algorithm (as per the Parkland Formula) or to a control group receiving only the standard resuscitation algorithm. These subjects will then be followed during their hospital course for fluid requirements, urine output, infectious complication rates, liver/renal failure rates, abdominal compartment syndrome rates, and outcomes such as ICU days, total hospital days, and mortality. All adverse events will be monitored by a data safety monitoring board. Currently this is a planned pilot study with a future multi-center study planned based on the ...
Burns complicate the management and outcomes of trauma patients. As with injuries sustained but not associated with burns, the initial management of a combined burn/trauma patient is stabilization and resuscitation of the patient. Management of the b
Rationale: Health related quality of life (HRQoL) is defined as the impact an injury or illness has on quality of life, including the individuals perception of his or her injury or illness. The aim of this study was to investigate changes over time in HRQoL in burn-injured adults using the EQ-5D instrument.. Methods: Participants were 88 consecutively included burn patients treated at the Uppsala University Hospital Burn Center. Their mean age was 43.3 (SD 15.5), total body surface area burned 24.4 (SD 19.8) and full-thickness burn 10.7 (SD 14.5). The participants completed the EQ-5D during hospitalisation, and at 3, 6, 12 and 24 months after injury. The EQ-5D includes five dimensions: Mobility, Self-care, Usual activities, Pain/Discomfort and Anxiety/Depression. Within each dimension there are three severity levels: no problems, moderate problems or severe problems. In addition the participants rate their health state on a VAS scale from 0 to 100. In a follow-up study the participants ...
TY - JOUR. T1 - CD14- and toll-like receptor 4-dependent regulation of c-Fos, c-Jun and c-Jun phosphorylation in the adrenal gland after burn injury. AU - Cho, Kiho. AU - Crivello, Sicily D.. AU - Vanhook, Tajia G.. AU - Greenhalgh, David G.. PY - 2004. Y1 - 2004. N2 - Objectives: Although the pathophysiology of the adrenocortical response after injury has been described, alterations in the molecular profile (e.g. transcription factors) of the adrenal gland itself are not well understood. The regulation of c-Fos, c-Jun, and c-Jun phosphorylation in the adrenal gland after burn injury was investigated in this study. In addition, since burn injury is often associated with lipopolysaccharide (LPS)-mediated sepsis, we examined the involvement of the LPS signaling pathway in the regulation of these transcription factors utilizing CD14 knockout and C3H/HeJ (encoding defective toll-like receptor 4) mice. Methods: Adrenal glands harvested after an 18% total body surface area burn were subjected to ...
Learn about current and emerging therapeutic strategies for the treatment of severely burned pediatric patients in the ED or initial phase of the intensive care unit.
Control of wound sepsis is an important challenge in traumatology. However, increase in the drug-resistant bacteria makes this challenge considerably difficult in recent years. In this study, we attempted to control burn wound sepsis in rats by photodynamic treatment, which has been reported to be effective against some drug-resistant bacteria. A 20% TBSA (total body surface area) full-thickness burn was made in rat dorsal skin, and five days after injury, a suspension of P. aeruginosa was applied to the wound surface. At 30 min after infection, a methylene blue (MB) solution was applied to the wound surface; 5 min afterwards, the wound was illuminated with a 665-nm light emitting diode (LED) array for 10 min. This treatment (application of MB and illumination) was repeated 3 times successively. The averaged light intensity on the wound surface was 3.3 mW/cm2, the corresponding total light dose being 5.9 J/cm2. One week after injury, the numbers of bacteria in the blood and liver were counted by ...
The ability of vagal nerve stimulation to modulate the intestinal response to inflammation is just beginning to be understood. In this series of experiments, we investigated changes in small intestine enteric glia activation in a model of intestinal injury caused by severe burn. The enteric glia may, at least in part, be responsible for restoring intestinal barrier integrity following injury. Here we propose that the response of the enteric glia to intestinal injury may be modulated by the CNS via the vagus nerve. Our findings suggest that stimulating the vagus nerve at the time of injury may augment enteric glia cell activation and either prevent intestinal barrier injury or speed its recovery.. The results of this study demonstrated that severe burn injury increases activation of enteric glia cells as measured by increased intestinal GFAP mRNA expression, by confocal microscopy of intestinal segments stained for GFAP, and by utilizing in vivo imaging of luminescence from the intestine of ...
A thermal burn is a type of burn resulting from making contact with heated objects, such as boiling water, steam, hot cooking oil, fire, and hot objects. Scalds are the most common type of thermal burn suffered by children, but for adults thermal burns are most commonly caused by fire. Burns are generally classified from first degree up to fourth degree, but the American Burn Association (ABA) has categorized thermal burns as minor, moderate, and major, based almost solely on the depth and size of the burn. There are three (or sometimes four) degrees of burns, in ascending order of severity and depth. For more info, see Burn#Signs and symptoms. According to Jacksons thermal wound theory, there are three zones of major burn injury. Zone of coagulation is the area that sustained maximum damage from the heat source. Proteins become denaturated, and cell death is imminent due to destruction of blood vessels, resulting in ischemia to the area. Injury at this area is irreversible (coagulative ...
1980 (English)In: Acta Anaesthesiologica Scandinavica, ISSN ISSN 0001-5172, Vol. 24, 288-294 p.Article in journal (Refereed) Published ...
PURPOSE: It is not known if the recovery of pediatric burn patients is age-dependent. The aim of this study was to investigate the effect of age on the recovery of body composition of severely burned children. PROCEDURES: Pediatric patients with massive burns, ,or= 40% of total body surface area, were followed over 2 years. Patients were divided into two age groups: 0-3.9 years old and 4-17.9 years old at the time of burn. Body composition was determined at hospital discharge, 6, 9, 12, 18, and 24 months after burn using dual-X-ray absorptiometry. Data analysis was performed using a two way ANOVA followed by Tukeys correction when appropriate. Significance was accepted at p,0.05. FINDINGS: Twenty-four patients were enrolled (age 0-3.9: n=9; age 4-17.9: n=15). Percent changes in height and bone mineral content were significantly increased in the younger age group, p,0.05. In contrast, percent changes in lean body mass were significantly lower in younger patients, p,0.05. Percent changes in total ...
TY - JOUR. T1 - Inhibition of selectin- and integrin-mediated inflammatory response after burn injury. AU - Nwariaku, Fiemu E.. AU - Sikes, Patricia J.. AU - Lightfoot, Ellis. AU - Mileski, William J.. PY - 1996/6. Y1 - 1996/6. N2 - Inflammation and microvascular injury in the areas adjacent to burn wounds produces extension of postburn tissue necrosis. Leukocytes are potent mediators of the local inflammatory response preceding tissue necrosis, and the selectin and integrin adhesion molecules have been implicated in leukocyte-mediated tissue destruction. We sought to examine the role of L- selectin (CD62-L) and CD18 in leukocyte accumulation and tissue necrosis following burn injury. New Zealand White rabbits (n = 36) were subjected to burn injury and were randomized to treatment with saline (control) or monoclonal antibodies to L-selectin or CD18. Animals given the anti-L- selectin antibody demonstrated reduced immunohistochemical evidence of leukocyte accumulation at 24 hr postinjury but did ...
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The Burn Prevention Award is awarded is presented to an ABA member for contribution in burn prevention. It recognizes prevention leaders in the burn community who have achieved wide-scale reduction of burn injuries and/or made progress toward elimination of burn injuries utilizing community partnerships. This award also intends to showcase the outstanding efforts of burn prevention achievements of maintained superior prevention efforts and advanced practices to improve safety. The winner is selected by the ABA Burn Prevention Committee and he/she receives an award of $1,500. The winner will be notified prior to the Annual Meeting and is required to attend to receive the award. The award will be presented at the ABAs Annual Meeting during the Opening Plenary and Awards Ceremony.. ...
ISSUES IN MEDICINE. Ethical decision making in severe paediatric burn victims H Rode; A J W Millar; B Castle; J Lyle The life of a patient is the only life the patient has - can we really make a judgment call on who to treat or not? J Puchula (from his address at the 2008 congress of the European Club for Paediatric Burns, Gdansk). The matter of triaging severe burns so that expensive and potentially futile treatment should not be initiated was discussed in a priority setting process by the Western Cape Health Department, and led us to question the validity of such an approach. The provision of equitable, accessible and appropriate burn care in South Africa faces many problems, particularly for patients with major burns. Approximately 3.2% of South Africas population suffer burns annually, of whom 50% are less than 20 years of age, and burns are the leading cause of unnatural death under the age of 5 (personal communication - M Pedan, MRC).1 Burn care in South Africa varies enormously in ...
The skin has been described as the largest organ of the integumentary system (Levenson, 2008). One condition affecting the skin organ is burn injuries. Serious or severe burn injuries have been described as a life-threatening state that challenges all of the integrating systems in the body (Sveen, Dyster-Aas, & Willebrand, 2009). Serious burn injuries are […]. ...
1. Sittig K, Deitch EA. Effect of bacteremia on mortality after thermal injury. Arch Surg. 1988;123:1367-70 2. Housenger TA, Brinkerhoff C, Warden GD. The relationship between platelet count, sepsis and survival in pediatric burn patients. Arch Surg. 1993;128:65-7 3. Chrysopoulo MT, Jeschke MG, Dziewulski P. et al. Acute renal dysfunction in severely burned adults. J Trauma. 1999;46:141-4 4. Ward PA, Till GO. Pathophysiologic events related tothermal injury of skin. J Trauma. 1990;30(Suppl 12):S75-9 5. Holm C, Horbrand F, von Donnersmarck GH. et al. Acute renal failure in severely burned patients. Burns. 1999;25:171-8 6. Kim GH, Oh KH, Yoon JW. et al. Impact of burn size and initial serum albumin level on acute renal failure occurring in major burn. Am J Nephrol. 2003;23:55-60 7. Wyble CW, Desai TR, Clark ET. et al. Physiologic concentrations of TNFa and IL-1b released from reperfused human intestine upregulate E-Selectin and ICAM-1. J Surg Res. 1996;63:333-8 8. Kuwabara Y, Kato T, Sato A. et ...
TY - JOUR. T1 - Effects of arginine supplementation on antioxidant enzyme activity and macrophage response in burned mice. AU - Tsai, Hui J.. AU - Shang, Huey Fang. AU - Yeh, Chiu L.. AU - Yeh, Sung Ling. PY - 2002. Y1 - 2002. N2 - This study investigated the effect of arginine (Arg) supplementation on antioxidant enzyme activities and macrophage response in burned mice. Experiment 1: 60 male BALB/c mice were assigned to two groups. One group was fed a control diet with casein as the protein source, the other group was supplemented with 2% Arg in addition to casein. The two groups were isonitrogenous. After 4 weeks, all mice received a 30% body surface area burn injury. The antioxidant enzyme activities and lipid peroxides in the tissues were analyzed. Experiment 2: 20 mice were divided into two groups and burn injury was induced after feeding for 4 weeks as described in experiment 1. Twenty-four hours after the burn, tumor necrosis factor-α (TNF-α) secreted by cultured peritoneal macrophages ...
Vancomycin pharmacokinetics are significantly altered following burn injury, requiring a higher total daily dose to achieve adequate serum concentrations. Wide interpatient variability necessitates close, frequent monitoring of serum concentrations for efficacy and safety. The aim of this study is to systematically evaluate published data regarding vancomycin pharmacokinetic alterations in burn patients, to determine whether evidence-based recommendations for dosing and monitoring can be formulated, and to identify future research opportunities. The systematic review included studies published in English, involved human subjects with at least a 10% TBSA burn who received vancomycin intravenously, and obtained serum concentration(s). Database searches returned 130 titles for review. Twelve studies met a priori inclusion criteria. The most common dosing regimens in adult and pediatric patients were 5 to 20 mg/kg/dose every 6 to 8 hours. Mean trough concentrations were 7.24 ± 1.5 mg/L. Only 12.5% of
The occurrence of burn injuries are more common then you might think in personal injury cases.. According to the National Hospital Discharge Survey, over 60% of the estimated U.S. acute hospitalizations related to burn injury were admitted to 128 burn centers. Such centers now average over 200 annual admissions for burn injury and skin disorders requiring similar treatment. The other 4,500 U.S. acute care hospitals average less than 3 burn admissions per year.. According to the American Burn Association, in 2013 alone there were 450,000 burn victims requiring emergency treatment.. Burn injuries are caused by fires from negligent electrical wiring, defective products used at construction sites, explosions, toxic chemical exposure and gasoline fires caused by high-speed car, truck, and motorcycle accidents.. According to the Mayo Clinic, there are three classifications of burns:. First-degree burn.. This minor burn affects only the outer layer of the skin (epidermis). It may cause redness, ...
Rationale. Severe thermal injury is one of the most devastating physical and psychological injuries a person can suffer. Over 2 million burn injuries are brought to medical attention in the United States per year. Of these, there are 14,000 deaths and approximately 20,000 sustain injuries requiring admission to a specialized burn unit.(1) About 75,000 patients require hospitalization each year, and 25,000 of those remain hospitalized for more than 2 months.(2) The most common mechanisms of burn injury are flame and scalding, and the upper extremity, head and neck are the most common body areas involved.(3). Goals of burn treatment include survival of the patient with rapid wound healing, minimal scarring and abnormal pigmentation, and cost-effectiveness. The optimal outcome is restoration, as nearly as possible, to the pre-burn quality of health and psychological well being.(4). The burn wound is a complex and dynamic injury characterized by a central zone of coagulation, surrounded by an area ...
Hannah Storm returned to work on New Years Day after a three-week absence to recover from severe burn injuries following a freak propane grill explosion at her home. Storm was part of ABCs telecast of the Rose Parade Tuesday, and she shared her story of the incident. ABC also showed graphic images of the injuries
The purpose of the study is to identify the inflammatory and coagulation pathways and mechanisms that are activated immediately following burn injury, and how they affect outcomes in terms of organ failure and death. This study also addresses the limitation of current tests (PT, PTT, and platelet counts) employed to identify coagulation disturbances in severely injured patients both in a comprehensive and rapid manner ...
In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically. Therefore, for paediatric patients in particular, identifying silver dressings that are associated with lower levels of pain and rapid wound re-epithelialisation is imperative. This study will determine whether there is a difference in time to re-epithelialisation and pain and distress experienced during wound care procedures among Acticoat™, Acticoat™ combined with Mepitel™ and Mepilex Ag™ dressings for acute, paediatric partial thickness burns. Children aged 0 to 15 years with an acute partial thickness (superficial partial to deep partial thickness inclusive) burn injury and a burn total body surface area of ≤10% will be eligible for the
Although the proliferation of collagen-producing cells following burn injury is the bodys natural response to trauma, the excessive collagen production
GRANTS / FUNDING (2014-19 RELEVANT TO SUBJECT) ScarX Technologies Inc. (2016-18). A Double Blind, Placebo Controlled, Randomized, Dose Ranging Study to Evaluate the Safety and Tolerability of SCX-001 Cream in Healthy Volunteers with Induced Dermal Incisions.. E.E. Tredget (PI) Total amount $461,216. Exciton Technologies (2013-14). A randomized, Site-Matched Controlled Trial of exSalt PTF wound dressing compared to Xeroform Petrolatum Dressing for the Management of Partial Thickness Donor Site. E.E. Tredget (PI) Total amount $19,054. United States Department of Defense Research Grants. 1. The Role of Nefopam in Hypertrophic Scarring following Burn Injury. TE Tredget, PI, David Greenhalgh, MD (site PI), Dates: October 2019 - Dec 2023 Budget: $3,458,000 US over 4 years. 2. Acute Burn ResUscitation Prospective Multicenter Trial (ABRUPT). David Greenhalgh, MD (PI), Robert Cartotto (CoI) TE Tredget, Site PI. Dates: October 2016 - September 2020. 3. Transfusion requirements in burn care evaluation ...
NASHVILLE - The Tennessee State Fire Marshals Office is highlighting National Burn Awareness Week (February 4-10, 2018) by sharing basic burn and scald prevention tips and reminding consumers that everyday household items can be burn hazards if not used or stored with care.
Background: Acute renal failure (ARF) is not a rare occurrence in severe burns and is an important complication leading to an increase in mortality. The severity of the burn is largely determined by the burn size, and severe burns are likely to cause enough loss of extracellular fluid and albumin from plasma volume to produce shock and hypoalbuminemia. Hypothesis: We hypothesized that initial serum albumin level may be useful as an indicator of prognosis and severity of injury in burned patients. Methods: The clinical characteristics of 147 adult patients with second- and third-degree burns covering 30% or more of their body surface area were analyzed retrospectively. Logistic regression was used to estimate the relative risks of ARF and mortality associated with the larger burn size and the lower serum albumin level at admission. Results: Mean burned body surface was 60.0 +/- 21.8% (range 30-100%). Twenty-eight (19.0%) out of 147 patients experienced ARF, defined as a serum creatinine ,/=2 ...
TY - JOUR. T1 - Cryptococcal encephalitis in thermally injured mice is accelerated by type 2 T-cell responses. AU - Furukawa, Katsunori. AU - Kobayashi, Makiko. AU - Sasaki, Hidetaka. AU - Herndon, David. AU - Pollard, Richard B.. AU - Suzuki, Fujio. PY - 2002. Y1 - 2002. N2 - Objective: To explore the pathogenic role of burn-associated type 2 T-cell responses on the development of cryptococcal encephalitis in mice with severe thermal injuries. Design: Experimental Cryptococcus neoformans infection in normal mice was compared with that in thermally injured mice (TI mice), normal mice heated with a mixture of interleukin (IL)-4 and IL-10, or normal mice inoculated with burn-associated type 2 T cells. Setting: University research laboratory. Subjects: Male BALB/c mice, 8 to 10 wks of age. Interventions: We prepared four groups of mice as follows: a) normal mice, b) TI mice, c) normal mice treated with the IL-4/IL-10 mixture, and d) normal mice inoculated with burn-associated type 2 T cells. These ...
Gluconeogenesis plays an integral role in the maintenance of glucose homeostasis in humans, contributing about one-third of glucose produced in the postabsorptive state and all glucose produced when hepatic glycogen is depleted by starvation (6, 23-25). Because the results of in vivo experiments in humans and animals (12-15, 20) and in vitro perfused rat liver studies (11, 27) have demonstrated a close correlation between the rate of glucose production and the flux of gluconeogenic substrates, it is believed that gluconeogenic precursor supply plays a major role in the regulation of glucose production (12,13,20). Several studies in vivo support this concept. For example, we and others have demonstrated that the hyperglycemic response to severe burn injury and sepsis is a direct result of an increased rate of glucose production, which is associated with a concomitant increase in the fluxes of alanine and lactate, major gluconeogenic substrates (15, 39). The proposed regulatory role of precursor ...
Abdominal compartment syndrome (ACS) is defined as a sustained intra-abdominal pressure (IAP) | 20 mmHg (with or without an abdominal perfusion pre...
Severe burn injuries require painful skin grafts, leave scars, and can cause long-term damage to organs. Our burn injury lawyers fight to obtain justice.
Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0-12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the first, the seventh, the fourteenth and the 21st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classified as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no significant difference were present. Also, PCT and neopterin levels within the first 24 hours following the burn were detected higher in PG than HCG. CRP and ...
BACKGROUND: In the treatment of burns, patients own skin is the preferred material to cover burn wounds, resulting in the need to create a donor site wound. Enhancement of healing of the donor site wound would be beneficial in burn patients. Insulin, an anabolic agent, is used routinely to treat hyperglycemia after injury. We investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA). METHODS: FSR of the donor site wound protein was measured in pediatric patients randomized to control (n = 13) and insulin (n = 10) treatments. Depending on the postoperative day when the tracer study was done, studies were divided into early (days , 5) and late (days = 5) periods. RESULTS: FSR of the donor site wound protein was greater in the insulin group at the early period of wound healing (control vs insulin, 8.2 ± 3.8 vs 13.1 ± 6.9% per day; P ...
Major burn Synonyms Severe Burn Burn Injury Burn Wound Related conditions Burn Shock Burn Trauma 1. Description of the problem Major burns can be devastating injuries. They have historically been defined as ,20% total body surface area (TBSA), as this level of tissue destruction is associated with increased capillary leak and release of inflammatory cytokines,…. ...
Treatment focuses on reconstructive surgery in the head and neck area, reconstruction of the breast in cancer patients and extremitypreserving microsurgery. Our centre for severe burn victims offers primary treatment to burn victims that is then followed up by secondary treatment in the form of highly specialised reconstructive plastic surgery. The department also provides the full range of aesthetic surgery.. Since 1997 the department headed up by Professor Norbert Pallua has been at the forefront of plastic and aesthetic surgery. Because of the hospitals affiliation with the Rhenish-Westphalian Technical University in Aachen, the Department for Plastic Surgery is able to offer optimum treatment methods reflecting the latest technical and scientific developments. Throughout the treatment, patients benefit from all the services and security provided by a major hospital where there are people on duty around the clock.. The department is the only plastic surgery centre in Germany accredited by ...
ObjectiveEnteral glutamine supplements have been shown to reduce infectious morbidity in trauma patients, but their effect on burn patients is not known. The objective of this study was to measure the impact of enteral glutamine supplementation on infectious morbidity, length of care, and the immune
TY - JOUR. T1 - Analysis of deep vein thrombosis in burn patients. AU - Fecher, A. M.. AU - OMara, M. S.. AU - Goldfarb, I. W.. AU - Slater, H.. AU - Garvin, R.. AU - Birdas, T. J.. AU - Caushaj, P. F.. PY - 2004/9. Y1 - 2004/9. N2 - Objective: Deep vein thrombosis (DVT) represents a major cause of morbidity in surgical patients. Controversial reports exist on the incidence of DVT in burn patients. We report our experience over a 10-year period. Methods: Patients admitted to our Burn Unit over the period 1991-2001 and diagnosed with DVT were identified. Their records were retrospectively reviewed for demographic factors, extent and severity of burn injury and outcome. Results: A total of 4102 patients were admitted to the WPH Burn unit during the study period. All patients received routine subcutaneous heparin prophylaxis. Ten patients were diagnosed with DVT (0.25%). Compared to our total burn population, these patients were older (mean age 47±22.7 years versus 35±22 years P=0.14) and had ...
Infections due to pseudomonas are still the major lethal complication in burn injury. Attempts to eliminate these organisms, including the use of topical and systemic antibiotics, have been encouraging but have not succeeded in removing them as the primary killer in this disease. The need for a better understanding of the burn patients host defense system is apparent in order to improve the high mortality induced by these organisms. Granulocytes have been shown to be critically defective in number and function in patients with leukemia and cancer who have pseudomonas infections. If granulocytes playa crucial role in these diseases, it would seem reasonable to assess their status in burn injury. While little data is available on granulocyte numbers in humans, an absolute granulocytopenia has been observed in the scald burn rat model which is intensified in the presence of pseudomonas infection. Reports regarding granulocyte function during burn injury are conflicting, and vary according to ...
Abstract Burn injury causes a major systemic catabolic response that is associated with mitochondrial dysfunction in skeletal muscle. We investigated the effects of the mitochondria-targeted peptide antioxidant Szeto-Schiller 31 (SS-31) on skeletal muscle in a mouse burn model using in vivo phosphorus-31 nuclear magnetic resonance ((31)P NMR) spectroscopy to noninvasively measure high-energy phosphate levels; mitochondrial aconitase activity measurements that directly correlate with TCA cycle flux, as measured by gas chromatography mass spectrometry (GC-MS); and electron paramagnetic resonance (EPR) to assess oxidative stress. At 6 h postburn, the oxidative ATP synthesis rate was increased 5-fold in burned mice given a single dose of SS-31 relative to untreated burned mice (P=0.002). Furthermore, SS-31 administration in burned animals decreased mitochondrial aconitase activity back to control levels. EPR revealed a recovery in redox status of the SS-31-treated burn group compared to the ...
We attempted to monitor the healing process of burn injuries by multiwavelength photoacoustic (PA) measurement. Deep dermal burn with 20% total body surface area was made in the dorsal skins of rats. The wavelengths of 532 nm, 556 nm, 576 nm and 600 nm were used: 532 nm is isosbestic point for oxyhemoglobin (HbO2) and deoxyhemoglobin (HHb); 576 nm is HbO2 absorption dominant; and 556 nm and 600 nm are HHb absorption dominant. At 532 nm, 556 nm and 576 nm, the depths of PA signal peak were shifted to the shallower region of the wound with the elapse of time, which was found to reflect angiogenesis due to wound healing by histological analysis. The amplitudes of PA signals increased at all the wavelengths until 24 h postburn time. At 48 h postburn time, the signal amplitude continued to increase at 532 nm and 576 nm, while it decreased at 556 nm and 600 nm. This is attributable to the change from a shock phase to the phase of hyperdynamic state, which is accompanied by increases in cardiac output ...
Superficial (1st degree) - this is when only the top layer of skin has been damaged. These are the most minor burns. Often the only sign is a reddening of the skin. Minor sunburn falls into this category of burns.. Partial thickness (2nd degree) - these burns cause blisters in the skin due to the damaged tissue releasing fluid.. Full thickness (3rd degree) - this is the most serious type of burn. In a full thickness burn, every layer of the skin has been affected and the underlying bone, muscle or fat may have also been damaged.. It is important to remember that a burn may consist of areas of differing thicknesses. For example, a full thickness burn may be surrounded by areas of partial and superficial thickness. Want to learn more about first aid? Have a go at one of our free online first aid courses. ...
Mutant Abcc6-/- mouse as a model for heterotopic ossification following thermal injury, Thea Price, MD; Qiaoli Li, PhD; and Jouni Uitto, MD, PhD (PI). ...
A multiresistant P. aeruginosa, defined as an organism resistant to three classes of antipseudomonal antimicrobials, was isolated in only 1 patient. This patient had no signs of systemic sepsis and did not receive systemic antimicrobials. In 22 patients the first isolate was sensitive to all systemic antipseudomonal antibiotics. Only 3 were treated with systemic antibiotics. Isolates with resistance to systemic antimicrobials were cultured from 9 patients as the first positive wound swab. Four of these 9 patients received systemic antibiotics according to the sensitivities of the cultured isolates.. Table 1 also details the sensitivities of 53 isolates to topical antimicrobial agents. Notably, only 4 were sensitive to povidone-iodine, but all were sensitive to chlorhexidine.. Wound dressings and management. Table 2 summarises the dressings used for the management of the 31 patients with clinically significant P. aeruginosa wound infection. A total of 368 dressing days were needed until negative ...
Bacterial keratitis is a rare but serious medical condition that carries a significant risk of permanent vision reduction or loss. A variety of bacteria have been isolated from patients with keratitis and it is postulated that these derive from local environmental sources. Predisposing factors include extended use of contact lenses, ocular surgical procedures, ocular disease and ocular injury. To our knowledge there has been no reported instance of bacterial keratitis developing after burns to the face.. We report a case of a 26-year-old male who developed pseudemonal keratitis during an acute burn admission following a house fire in 2011. The patient sustained full thickness facial burns as part of an injury totalling 63% total body surface area. During the admission he developed pseudemonal septicaemia and was noted to have new onset bilateral corneal opacifications and purulent ocular discharge on day 8. A diagnosis of severe fulminant bacterial keratitis was made and pseudomonas aeruginosa ...
Joseph M. Still, Jr., M.D., dedicated his entire professional life to improvements in the treatment of burn patients. He partnered with Doctors Hospital in Augusta to create the Joseph M. Still Burn Center, one of the worlds leading treatment facilities for burn victims.. His care for patients, however, carried beyond hospital walls. Dr. Still also founded the Southeastern Firefighters Burn Foundation, Inc., a non-profit organization devoted to helping burn patients and their families with non-medical necessities. The Foundation operates the Shirley Badke Retreat, a place for people to stay while their family members are in the burn center.. Leadership was a way of life for Dr. Still. At 13, he became an Eagle Scout, and numerous honors and achievements led to his nomination as one of the Outstanding Young Men in America. A Charlotte, N.C., native, Dr. Still attended Shorter College in Rome, Ga., where he received a Bachelor of Arts degree in biology and chemistry. He earned his medical ...
ASA 2018 Abstracts: Improved Post-burn Hypertrophic Scarring and Physical Recovery with Year-long Administration of Oxandrolone and Propranolol
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Joseph M. Still, Jr., M.D., dedicated his entire professional life to improvements in the treatment of burn patients. He partnered with Doctors Hospital in Augusta to create the Joseph M. Still Burn Center, one of the worlds leading treatment facilities for burn victims.. His care for patients, however, carried beyond hospital walls. Dr. Still also founded the Southeastern Firefighters Burn Foundation, Inc., a non-profit organization devoted to helping burn patients and their families with non-medical necessities. The Foundation operates the Shirley Badke Retreat, a place for people to stay while their family members are in the burn center.. Leadership was a way of life for Dr. Still. At 13, he became an Eagle Scout, and numerous honors and achievements led to his nomination as one of the Outstanding Young Men in America. A Charlotte, N.C., native, Dr. Still attended Shorter College in Rome, Ga., where he received a Bachelor of Arts degree in biology and chemistry. He earned his medical ...
TY - JOUR. T1 - Free split-cutaneous perforator flaps procured using a three-dimensional harvest technique for the reconstruction of postburn contracture defects. AU - Tsai, Feng Chou. AU - Yang, Jui Yung. AU - Mardini, Samir. AU - Chuang, Shiow Shuh. AU - Wei, Fu Chan. PY - 2004/1. Y1 - 2004/1. N2 - With recent advances in free-tissue transfer, microsurgical techniques have been used more frequently for the reconstruction of postburn contracture defects. Traditional methods, including full-thickness skin grafts and local flaps, often result in a good outcome; however, multiple operative procedures, long periods of splinting, and physical rehabilitation are often required. Free split-cutaneous perforator flaps, consisting of one large cutaneous paddle with two perforating vessels split into two separate skin regions, were used for two kinds of postburn contractures: rectangular and spatially separate defects. From September of 2000 to October of 2002, seven patients underwent this method of ...
Our SPiRiT Fund has supported the following research initiatives:. LIST OF PUBLICATIONS:. Blome-Eberwein, S. Lozano D.D, Amani H. Utility of Negative Pressure Wound Therapy with Instillation in a Burn Center. Burns Open 27 May 2018.. Blome-Eberwein S. Gogal, C. Weiss, M. Boorse, D. Pagella, P. Prospective Evaluation of Fractional CO2 Laser Treatment of Mature Burn Scars. Journal of Burn Care and Research, Col 37 #7, November/December 2016.. Blome-Eberwein S, Abboud M, Lozano DD, Sharma R, Eid S, Gogal C. Effect of Subcutaneous Epinephrine/Saline/Local Anestetic Vs Only Saline Injection on Split Thickness Skin Graft Donor Site Perfusion, Healing, and Pain. Journal of Burn Care and Research, December 2012.. Amani H, Lozano DD, Blome-Eberwein S. Brother, Have You Got a Light? Assessing The Need For Intubation in Patients Sustaining Burn Injury Secondary to Home Oxygen Therapy. Journal of Burn Care & Research, Vol 33 #6, November 2012.. Blome-Eberwein, Sigrid A. MD., Roarabaugh, Chad PA-C, Gogal, ...
Soak the burn in cool water for 15 minutes. If the burned area is small, put cool, clean wet cloths on the burn for a few minutes every day. Then put on an antibiotic cream or other creams or ointments prescribed by your doctor. Cover the burn with a nonstick dressing (for example, Telfa) and hold it in place with gauze or tape.. Check the burn every day for signs of infection, such as increased pain, redness, swelling or pus. If you see any of these signs, go to your doctor right away. To prevent infection, avoid breaking blisters.. Change the dressing every day. First, wash your hands with soap and water. Then gently wash the burn and put antibiotic ointment on it. If the burn area is small, a dressing may not be needed during the day. Make sure you are up-to-date on tetanus shots. If you arent sure, check with your doctors office.. Burned skin itches as it heals. Keep your fingernails cut short and dont scratch the burned skin. The burned area will be sensitive to sunlight for up to one ...
BACKGROUND AND OBJECTIVES: Non-ablative fractional laser-treatment is evolving for burn scars. The objective of this study was to evaluate clinical and histological long-term outcome of 1,540 nm fractional Erbium: Glass laser, targeting superficial, and deep components of mature burn scars. MATERIALS & METHODS: Side-by-side scar-areas were randomized to untreated control or three monthly non-ablative fractional laser-treatments using superficial and extra-deep handpieces. Patient follow-up were at 1, 3, and 6 months. Primary outcome was improvement in overall scar-appearance on a modified-Patient-and-Observer-Scar-Assessment-Scale (mPOSAS, 1 = normal skin, 10 = worst imaginable scar). Secondary outcomes included histology, patient satisfaction (0-10), patient-assessed improvement, and safety. RESULTS: Study was completed by 17 of 20 randomized patients with normotrophic (n = 11), hypertrophic (n = 5) or atrophic (n = 1) scars. Scar-appearance improved from laser-treatments (P , 0.001 vs. ...
This study of Missouri children demonstrates how a statewide, population based E code database can be used to describe burn injuries in children and identify populations at increased risk. In general, children ages 0-4 years had a higher burn injury rate than older children-a finding similar to other US reports.5-10 Investigators in Massachusetts found an estimated incidence rate for 0-2 year olds of 72 per 10 000 patient years.10 We found that African-American boys ages 0-4 years in urban counties and African-American girls in high poverty counties had raised injury rates. Like our study, MacKay and colleagues found that patients living in high poverty areas had higher rates of burns.10 A report from Baltimore also found that the majority of their hospitalized burn patients came from lower socioeconomic status homes.8. Scalds and fire related burns were the most common causes of burn injury in studies of hospitalized children,5-7,9 while hot objects and scalds were the most prominent causes of ...
The devastating series of fire events that occurred during the summers of 2007 and 2009 in Greece made evident the need for an operational mechanism to map burned areas in an accurate and timely fashion to be developed. In this work, Système pour lObservation de la Terre (SPOT)-4 HRVIR images are introduced in an object-based classification environment in order to develop a classification procedure for burned area mapping. The development of the procedure was based on two images and then tested for its transferability to other burned areas. Results from the SPOT-4 HRVIR burned area mapping showed very high classification accuracies ( 0.86 kappa coefficient), while the object-based classification procedure that was developed proved to be transferable when applied to other study areas.
Burn injuries place a significant burden on the healthcare system in South Africa. Early excision and management is the standard of care, and impacts upon survival in cases of large total body surface area burns. If the use of an autograft is limited owing to extensive burn injuries, cadavre skin is the gold standard for temporary management. A cadavre skin bank is needed in South Africa, and has not existed until very recently. Organ donation is increasing, while tissue donation is largely unknown, although tissue banking has been established in South Africa for cornea, bone and heart valves. The availability of tissue remains difficult. The high demand for tissue is not being met by current donations. South Africa is a rainbow nation, and varied cultural and religious considerations impact upon organ and tissue donation. A small number of healthcare workers were surveyed in order to gauge their willingness to become skin donors as part of research into the development of a campaign to raise ...
MISSION, KS--(Marketwired - Nov 24, 2014) - (Family Features) Its no surprise that as the holiday season approaches, family and friends gather to celebrate. With more cooking, decorating and rituals that include candles and open flames, the risk of house fires and pediatric burn injuries increase drastically during the month...
A skin burn treatment or cure varies depending on what caused the skin burn and of course the severity of the burn. First aid for various types of skin burns are discussed.
Glucose control has repeatedly been shown to influence favorable outcomes in the surgical intensive care unit (ICU). Intensive insulin therapy has recently been associated with reduced infections complications in burn patients. However, traditional protocols are associated with rates of severe hypoglycemia as high as 19%. Two commercial computer glucose control programs have reported rates of severe hypoglycemia (glucose ,50 mg/dl) of 0.6 and 0.4%. Recently, the authors burn ICU adopted an intensive insulin computer-based protocol created at their institution and already successfully in use in their surgical ICU. The authors hypothesized that their protocol can be used effectively in the burn patient population without an increase risk of severe hypoglycemia. All patients admitted to the burn ICU have blood glucose (BG) values checked routinely. With two consecutive hyperglycemic values ,200 mg/dl, patients are placed on a computer-based protocol intravenous insulin drip. Once initiated, BGs ...
Introduction: Pseudomonas aeruginosa is an opportunistic pathogen of clinical importance, particularly in immunocompromised and burn patients. This bacterium is becoming resistant to many antibiotics via intrinsic or acquired mechanisms. Mutations in anti-mutator genes, such as pfpI, can be a potential intrinsic mechanism of antibiotic resistance. This study aimed to evaluate the ...
On review of admissions over a 12-month period, we noted a significant number of women presenting with gypsy skirt burns. We describe all six cases to highlight the unique distribution of the wounds and the circumstances in which the accidents occurred. Four skirts were ignited by open fire heaters: two skirts ignited whilst the women were standing nearby, distracted with a telephone conversation; one brushed over the flame as she was walking past the heater; other whilst dancing in the lounge. One skirt was ignited by decorative candles placed on the floor during a social gathering. Another skirt was set alight by cigarette ember, whilst smoking in the toilet. Percentage surface area burned, estimated according to the rule of nines, showed that gypsy skirt burns were significant ranging from 7 to 14% total body surface area (TBSA) and averaging 9% TBSA. Two patients required allogenic split-skin grafts. Common sense care with proximity to naked flame is all that is needed to prevent this ...
Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineage differentiation, immunosuppressive, and anti-inflammatory potential which makes them suitable for treating skin wounds. However, the exact effects of hAMSCs on the healing of thermal burn skin wounds and their potential mechanisms are not explored. hAMSCs were isolated from amniotic membrane and characterized by RT-PCR, flow cytometry, immunofluorescence, and tumorigenicity test. We assessed the effects of hAMSCs and hAMSC conditional medium (CM) on wound healing in a deep second-degree burn injury model of mice. We then investigated the biological effects of hAMSCs and hAMSC-CM on the apoptosis and proliferation of heat stress-injured human keratinocytes HaCAT and dermal fibroblasts (DFL) both in vivo and in vitro. Next, we explored the underlying mechanisms by assessing PI3K/AKT and GSK3β/β
Burn wound cellulitis Diagnostic points - Infection occurs in uninjured skin surrounding a wound; signs of local infection progress beyond what is expected from burn-related inflammation Treatmen... more
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A city in Brazil is using tilapia skin as an experimental approach to burn treatment. Heres how the team came to the unconventional approach.
Ninety-nine children (propranolol n=46,control n=53) admitted at our facility between 2003 and 2016 were analyzed. Age at burn (propranolol 12±4 years, control 12±3 years,p=0.893) and total body surface area burned (propranolol 44±15%,control 49±14%,p=0.090) were comparable between groups. Measured VO2 max was higher in the propranolol group (25.5±6.0 mL/min/kg vs. 22.0±4.7 mL/min/kg,p=0.002) and was generally lower than estimated values. Age, sex, inhalation injury, body mass index, exercise time, and maximal speed were predictive of measured VO2 max in the control group. Age, sex, and maximal speed were predictive in the propranolol group. Backward selection yielded the formula [7.63+ 2.16 × sex(females=0,males=1)+ 0.41 × age(years)+ 0.15 × maximal speed(m/min)] (R2=0.6525 ...
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Dr. Alster and Dr. Nanni discuss the treatment of hypertrophic burn scars with pulsed dye laser. This is very important for the recovery of Burn Survivors.
Seven patients in the burn unit of the UF Health Shands Hospital were infected with a lethal, drug-resistant bacteria during that time.

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