A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
A general term for various neoplastic diseases of the lymphoid tissue.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
A PYRIDOXAL PHOSPHATE-containing enzyme that catalyzes the transfer of a formyl group from L-GLUTAMATE to N-formimidoyl-L-glutamate and TETRAHYDROFOLATE. This enzyme may also catalyze formyl transfer from 5-formyltetrahydrofolate to L-GLUTAMATE. This enzyme was formerly categorized as EC 2.1.2.6.
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Antibodies obtained from a single clone of cells grown in mice or rats.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
The large, metacentric human chromosomes, called group A in the human chromosome classification. This group consists of chromosome pairs 1, 2, and 3.
Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).
A cell line derived from cultured tumor cells.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
Established cell cultures that have the potential to propagate indefinitely.
SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.
Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Antibodies produced by a single clone of cells.
An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
Substances elaborated by viruses that have antigenic activity.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
DNA present in neoplastic tissue.
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Mapping of the KARYOTYPE of a cell.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Therapeutic act or process that initiates a response to a complete or partial remission level.
An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A group II chaperonin found in eukaryotic CYTOSOL. It is comprised of eight subunits with each subunit encoded by a separate gene. This chaperonin is named after one of its subunits which is a T-COMPLEX REGION-encoded polypeptide.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)

Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL) cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other EBV-positive BL cells express a restricted set of EBV gene products (type I latency) that are not known to overtly affect cell growth. Here we demonstrate that reestablishment of type I latency in EBV-negative Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resistance to apoptosis under growth-limiting conditions. The antiapoptotic effect of EBV was associated with a higher level of Bcl-2 expression and an EBV-dependent decrease in steady-state levels of c-MYC protein. Although the EBV EBNA-1 protein is expressed in all EBV-associated tumors and is reported to have oncogenic potential, enforced expression of EBNA-1 alone in EBV-negative Akata cells failed to restore tumorigenicity or EBV-dependent down-regulation of c-MYC. These data provide direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a novel model whereby a restricted latency program of EBV promotes B-cell survival, and thus virus persistence within an immune host, by selectively targeting the expression of c-MYC.  (+info)

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)

CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.  (+info)

Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)

Bruton's tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B cells is still unclear. This study represents a search for the substrate for Btk in vivo. We identified one of the major phosphoproteins associated with Btk in the preB cell line NALM6 as the Wiskott-Aldrich syndrome protein (WASP), the gene product responsible for Wiskott-Aldrich syndrome, which is another hereditary immunodeficiency with distinct abnormalities in hematopoietic cells. We demonstrated that WASP was transiently tyrosine-phosphorylated after B-cell antigen receptor cross-linking on B cells, suggesting that WASP is located downstream of cytoplasmic tyrosine kinases. An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk. A protein binding assay suggested that the tyrosine-phosphorylation of WASP alters the association between WASP and a cellular protein. Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown.  (+info)

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)

In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-crossblocking pairs), polyclonal anti-mu Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fab', F(ab')2 and F(ab')3 derivatives from anti-Fc mu mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (C mu2-C mu4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-Fd mu, or C mu1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb.  (+info)

Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)

Ligation of CD40 on the surface of B cells induces multiple phenotypic effects, many of which are mimicked by the EBV latent membrane protein 1 (LMP1) through its interaction with downstream components of the CD40 signaling pathway. Because the effects of LMP1 have been most closely studied in human Burkitt Lymphoma (BL) cell lines retaining a tumor biopsy-like phenotype in vitro, we have examined the response of a panel of such lines to CD40 ligation. Two distinct patterns of response were observed that were unrelated to the surface level of CD40 or to the EBV genome status of the lines. Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition. Aggregation was seen at lower doses than those required to elicit the other effects. By contrast, low responder (LR) lines showed no detectable response to CD40 mAbs, while their responses to sCD40L were limited to activation of NF-kappa B and up-regulation of CD95 only. However, in transfection experiments, LMP1 uniformly induced the full spectrum of phenotypic effects in both HR and LR lines. We conclude that some BL cell lines show a highly restricted response to CD40 ligation but remain fully susceptible to LMP1.  (+info)

Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)

Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans.  (+info)

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)

The consistent presence of EBV genomes in certain tumor types (in particular, AIDS-related central nervous system lymphomas and nasopharyngeal carcinomas) may allow novel, EBV-based targeting strategies. Tumors contain the latent (transforming) form of EBV infection. However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce lytic EBV infection, resulting in death of the host cell. We have constructed replication-deficient adenovirus vectors expressing the BZLF1 or BRLF1 immediate-early genes and examined their utility for killing latently infected lymphoma cells in vitro and in vivo. We show that both the BZLF1 and BRLF1 vectors efficiently induce lytic EBV infection in Jijoye cells (an EBV-positive Burkitt lymphoma cell line). Furthermore, lytic EBV infection converts the antiviral drug, ganciclovir (GCV), into a toxic (phosphorylated) form, which inhibits cellular as well as viral DNA polymerase. When Jijoye cells are infected with the BZLF1 or BRLF1 adenovirus vectors in the presence of GCV, viral reactivation is induced, but virus replication is inhibited (thus preventing the release of infectious EBV particles); yet cells are still efficiently killed. Finally, we demonstrate that the BZLF1 and BRLF1 adenovirus vectors induce lytic EBV infection when they are directly inoculated into Jijoye cell tumors grown in severe combined immunodeficiency mice. These results suggest that induction of lytic EBV infection in tumors, in combination with GCV, may be an effective strategy for treating EBV-associated malignancies.  (+info)

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)

In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene becomes transcriptionally activated as a consequence of the chromosomal translocation and shows preferential usage of promoter P1 over P2, a phenomenon referred to as promoter shift. In order to define the responsible regulatory elements within the Ig lambda locus, we studied the effect of the human Ig lambda enhancer (HuE lambda) on c-myc expression after stable transfection into BL cells. A 12 kb genomic fragment encompassing HuE lambda, but not HuE lambda alone, strongly activated c-myc expression and induced the promoter shift. To identify additional elements involved in c-myc deregulation, we mapped DNaseI hypersensitive sites within the 12 kb lambda fragment on the construct. Besides one hypersensitive site corresponding to HuE lambda, three additional sites were detected. Two of these elements displayed enhancer activity after transient transfection. The third element did not activate c-myc transcription, but was required for full c-myc activation and promoter shift. Deletion analyses of the c-myc promoter identified the immediate promoter region as sufficient for activation by the Ig lambda. locus, but also revealed that induction of the promoter shift requires additional upstream elements.  (+info)

What is Burkitt Lymphoma?. Burkitt lymphoma is a form of non-Hodgkins lymphoma which is a type of cancer that starts in the b-cells. Burkitt lymphoma is one of the fastest growing tumors. Burkitt lymphoma attacks the immune system and is fatal if not treated in a timely manner. There are three types of Burkitts lymphoma endemic, sporadic, and immunodeficiency- associated.. What causes Burkitt lymphoma? Who is affected?. The exact cause of Burkitt lymphoma is unknown, but there are factors associated with the disease such as Epstein-Barr. Individuals who are immunosuppressed have a higher risk factor for Burkitt lymphoma. Burkitt lymphoma primarily affects African children, and malaria may make children more vulnerable.. What are the symptoms of Burkitt lymphoma?. There are many symptoms associated with Burkitt lymphoma, including:. ...
An eight year old English boy presented with an abdominal undifferentiated Burkitt-like lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African endemic Burkitts lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was ...
Burkitt lymphoma (BL) (or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, was used to describe this disease in patients presenting with a soli...
Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells. Using more sensitive and specific transcriptome deep sequencing, we compared previously published small miRNA and long mRNA of a set of GC B cells and eBL tumors. MiRWalk2.0 was used to identify the validated target genes for the deregulated miRNAs, which would be important for understanding the regulatory networks associated with eBL development. We found 211 differentially expressed
Burkitt are highly aggressive lymphomas. As such, the goal of treatment is usually to cure the disease with aggressive therapy. From OncologyChannel: Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas. Burkitts lymphoma tends to occur most often in children and in adults with compromised immune systems. There are three distinct forms of this disease: endemic, sporadic, and immunodeficient.. ...
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Detection of Human IRAK2 by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line, Raji human Burkitts lymphoma cell line, K562 human chronic myelogenous leukemia cell line, and HeLa human cervical epithelial carcinoma cell line. PVDF Membrane was probed with 0.5 µg/mL of Human IRAK2 Monoclonal Antibody (Catalog # MAB6690) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for IRAK2 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 ...
Our laboratory is studying how antibody-forming cells respond to antigen by undergoing somatic hypermutation and class switch recombination so that they can produce higher affinity antibodies with more useful effector functions. The molecular and biochemical mechanisms of antibody variable region hypermutation and class switch recombination is being studied in mice that have mutations in various repair proteins in collaboration with Dr. Winfried Edelmann. In order to examine detailed molecular mechanisms, we are also studying how mutation is targeted to antibody genes and some oncogenes in human Burkitts lymphoma cell lines which are undergoing variable region mutation in culture. These cell lines and genetically defective mice are being used to study the role of activation induced deaminase (AID), mismatch repair and error prone polymerases in the variable region hypermutation and isotype switching. The analysis of these events also involves the examination of AID activity biochemically and, ...
Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands (CCL19, CCL21, CXCL12 and CXCL13) by endothelial cells inside the lymph nodes facilitates the trans-endothelial migration (TEM) of these cells through high endothelial venules into the lymph node parenchyma. It is known that CXCR7, a second CXCL12 receptor, regulates TEM of CXCR4+CXCR7+ tumor cells towards a CXCL12 source. In this study, we set out to assess the potential stimulation by CXCL12 of tumor cell TEM towards other chemokines and whether CXCR7 might be able to regulate such effects. The human Burkitts lymphoma cell line NC-37, which expresses CXCR4, CXCR5, CXCR7 and CCR7, was selected as a model system. TEM of these cells through a human HUVEC endothelial cell monolayer was used as the main model system for these studies. Regulation of their TEM
Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands (CCL19, CCL21, CXCL12 and CXCL13) by endothelial cells inside the lymph nodes facilitates the trans-endothelial migration (TEM) of these cells through high endothelial venules into the lymph node parenchyma. It is known that CXCR7, a second CXCL12 receptor, regulates TEM of CXCR4+CXCR7+ tumor cells towards a CXCL12 source. In this study, we set out to assess the potential stimulation by CXCL12 of tumor cell TEM towards other chemokines and whether CXCR7 might be able to regulate such effects. The human Burkitts lymphoma cell line NC-37, which expresses CXCR4, CXCR5, CXCR7 and CCR7, was selected as a model system. TEM of these cells through a human HUVEC endothelial cell monolayer was used as the main model system for these studies. Regulation of their TEM
In this new business intelligence Burkitt Lymphoma Therapeutics market report, PMR serves a platter of market forecast, structure, potential, and socioeconomic impacts associated with the global Burkitt Lymphoma Therapeutics market. With Porters Five Forces and DROT analyses, the research study incorporates a comprehensive evaluation of the positive and negative factors, as well as the opportunities regarding the Burkitt Lymphoma Therapeutics market.. With having published myriads of Burkitt Lymphoma Therapeutics market reports, PMR imparts its stalwartness to clients existing all over the globe. Our dedicated team of experts deliver reports with accurate data extracted from trusted sources. We ride the wave of digitalization - facilitate clients with the changing trends in various industries, regions and consumers. As customer satisfaction is our top priority, our analysts are available 24/7 to provide tailored business solutions to the clients.. Request Sample Report @ ...
The nuclear enzyme poly(ADP-ribose) polymerase (PADPRP) is thought to play a role in DNA recombination, replication, and repair. In view of the implication of these processes in tumorigenesis, and based on preliminary evidence which indicated the presence of an extraneous polymorphic restriction fragment for murine PADPRP loci in strains of mice susceptible to plasmacytomas, we investigated correlations between the restriction fragment length polymorphism of the PADPRP gene(s) and human Burkitt lymphoma. No increase in the frequency of polymorphisms on chromosome 1 (containing the active gene) or on chromosome 14 (a pseudogene) was observed. However, restriction fragment length polymorphism analysis of PADPRP sequences on chromosome 13 (either a processed pseudogene or a gene with extensive identity to PADPRP) revealed that of 19 DNA samples derived from endemic Burkitt lymphoma all contained at least one copy of a rare allele (B). Simple two-allele (A/B) polymorphisms in this PADPRP-like locus ...
Mouse monoclonal antibody raised against native CD19. Native purified CD19 from Daudi human Burkitt lymphoma cell line. (MAB4370) - Products - Abnova
Burkitts lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitts lymphoma is poor. Here we sought to identify a role of histone deacetylase 6 (HDAC6) in the metastasis of Burkitts lymphoma cells. Burkitts lymphoma cells were pharmacologically treated with niltubacin, tubacin or sodium butyrate (NaB) or transfected with siRNAs to knock down the expression of HDAC6. Cell migration and invasion ability were measured by transwell assay, and cell cycle progression was analyzed by flow cytometry. Cell adhesion and proliferation was determined by CellTiter-Glo luminescent cell viability assay kit. Cell morphological alteration and microtubule stability were analyzed by immunofluorescence staining. Effect of niltubacin, tubacin and NaB on acetylated tubulin and siRNA efficacy were measured by western blotting. Suppression of histone deacetylase 6 activity significantly compromised the
BURKITT-LYMPHOM (PATHOLOGIE); ZELLLINIEN + ZELLLINIENISOLIERUNG (CYTOLOGISCHE METHODEN); EPSTEIN-BARR-VIRUS (VIROLOGIE); TRANSKRIPTION (MOLEKULARE GENETIK); DNA-MIKROARRAY TECHNOLOGIE; BURKITT LYMPHOMA (PATHOLOGY); CELL LINES + CELL LINE ISOLATION (CYTOLOGICAL METHODS); EPSTEIN-BARR-VIRUS (VIROLOGY); TRANSCRIPTION (MOLECULAR GENETICS); DNA ...
Gutzeit, C., N. Nagy, M. Gentile, K. Lyberg, J. Gumz, H. Vallhov, I. Puga, E. Klein, S. Gabrielsson, A. Cerutti, and A. Scheynius. 2014. Exosomes derived from Burkitts lymphoma cell lines induce proliferation, differentiation, and class-switch recombination in B cells. J. Immunol. 192: 5852-5862.. In the published version of Fig. 6A, the FACS dotplot shown for the stimulation of DG75-COex at 25 μg in the presence of IL-21 was inadvertently duplicated from the 5 μg/IL-21 panel. The indicated frequency of 5% of CD38highCD20low B cells, however, is correct. This correct value of 5% was used in Fig. 6B, so the error in Fig. 6A did not influence the interpretation of the results and conclusions of this work. Fig. 6A has now been corrected with the correct dotplot for stimulation of DG75-COex at 25 μg in the presence of IL-21. The corrected version of Fig. 6 is shown below. The figure legend was correct as published and is shown below for reference. Fig. 6 has also been corrected in the online ...
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA methylation and diminished PUMA expression, which can be reactivated following inhibition of DNA methyltransferases. These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics.. ...
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HLDA WorkshopHLDA VI-WS Code AS A048 Concentration Unitmg/mLConcentration1Quantity0.1 mgVolume0.1ImmunogenRaji cells: human Burkitts lymphoma cell...
The expression of several microRNAs (miRNAs) is known to be changed in Burkitt lymphoma (BL), compared to its normal counterparts. Although for some miRNAs, a role in BL was demonstrated, for most of them, their function is unclear. In this study, we aimed to identify miRNAs that control BL cell growth. Two BL cell lines were infected with lentiviral pools containing either 58 miRNA inhibitors or 44 miRNA overexpression constructs. Eighteen constructs showed significant changes in abundance over time, indicating that they affected BL growth. The screening results were validated by individual green fluorescent protein (GFP) growth competition assays for fifteen of the eighteen constructs. For functional follow-up studies, we focused on miR-26b-5p, whose overexpression inhibited BL cell growth. Argonaute 2 RNA immunoprecipitation (Ago2-IP) in two BL cell lines revealed 47 potential target genes of miR-26b-5p. Overlapping the list of putative targets with genes showing a growth repression phenotype in a
Synonyms for Burkitt's tumor in Free Thesaurus. Antonyms for Burkitt's tumor. 2 synonyms for tumor: neoplasm, tumour. What are synonyms for Burkitt's tumor?
Burkitt is an ancient name of Anglo-Saxon origin, and may refer to: Denis Parsons Burkitt, surgeon Francis Crawford Burkitt, British theologian Jack Burkitt, English footballer James Parsons Burkitt, ornithologist M. C. Burkitt, British palaeohistorian William Burkitt, biblical expositor and vicar in Dedham, Essex, England Judge Sir William Burkitt Burkitts lymphoma Burkitt name origin Alternative origin of Burkitt ...
Burkitts lymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. We examined the potential role of the p53 gene in BL tumorigenicity using an in vitro assay that measures p53-dependent cell cycle arrest in the G1 phase of the cell cycle and an in vivo athymic murine model that detects differences in the tumorigenicity of BL cell lines. A highly significant inverse correlation was found between the ability of BL cells to arrest in G1 after irradiation and their tumorigenicity in athymic mice, consistent with the notion that loss of p53 function is associated with increased tumorigenicity. Inactivation of wild-type (wt) p53 function by expression of the human papillomavirus E6 protein in the AG876V BL cell line, which carries both wt and mutant p53 proteins, rendered the cell line significantly more tumorigenic in athymic mice. Transfection of the wt p53 gene into the p53 mutant and highly tumorigenic BL-41 cell line ...
HLDA WorkshopHLDA 10Quantity100 testsVolume0.4ImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane glycopro...
HLDA WorkshopHCDM/HLDA 10Quantity100 testsVolume1.0 mLImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane gl…
HLDA WorkshopHCDM/HLDA 10Quantity100 testsVolume2.0 mLImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane gl…
The Meyer Cancer Center recently profiled Dr. Lisa Roth and the far-reaching impact of her work in finding new targeted therapies to treat young patients with Burkitt lymphoma. Burkitts is an aggressive form of non-Hodgkin lymphoma that is often fatal. Finding alternative therapy options is important because, As many as 85 percent of children with Burkitt lymphoma respond…
Burkitts lymphoma is a sort of aggressive B-cell lymphoma. This condition is most usually observed in youngsters and isolated into three types:. - Endemic - this is generally seen in children living in Africa. Usually, this kind of Burkitts lymphoma affects the facial bones such as the jaw, the intestines such as the distal ileum and cecum. Other stomach parts such as the ovaries and kidneys can also be affected.. - Sporadic/Non-African - found outside of Africa and affects the same parts as that of the endemic mixed bag.. - Immunodeficiency associated - this kind of Burkitts lymphoma is usually seen in HIV patients or patients taking insusceptible suppressive drugs.. Causes. Alongside the stated associated factors, Burkitts lymphoma is exceptionally joined with Epstein-Barr virus and jungle fever. The virus creates a change inside the B-cells, a kind of lymphocyte found in the safe system. Exposure to jungle fever weakens the cells resistance to the virus effects, making it one of the ...
TY - JOUR. T1 - Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes. AU - Piccaluga, Pier Paolo. AU - De Falco, Giulia. AU - Kustagi, Manjunath. AU - Gazzola, Anna. AU - Agostinelli, Claudio. AU - Tripodo, Claudio. AU - Leucci, Eleonora. AU - Onnis, Anna. AU - Astolfi, Annalisa. AU - Sapienza, Maria Rosaria. AU - Bellan, Cristiana. AU - Lazzi, Stefano. AU - Tumwine, Lynnette. AU - Mawanda, Michael. AU - Ogwang, Martin. AU - Calbi, Valeria. AU - Formica, Serena. AU - Califano, Andrea. AU - Pileri, Stefano A.. AU - Leoncini, Lorenzo. PY - 2011/3/31. Y1 - 2011/3/31. N2 - Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a unique molecular entity, distinct from other B-cell malignancies. Indeed, by ...
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
Background: The epidemiology of Burkitt Lymphoma (BL) shows that the endemic type is mainly confined to equatorial Africa and has a very close association with the Epstein-Barr virus (EBV), while the sporadic variant shows only a 20% association with EBV and is seen mainly in Europe and North America. An immunodeficent form of BL has been described more recently. This study aimed to describe the epidemiological characteristics and survival of children presenting with BL to Tygerberg Hospital, Cape Town, in South Africa. Methods: A retrospective, descriptive study reviewed all pediatric cases of Burkitt lymphoma at Tygerberg Hospital Oncology Unit between 1 January 1995 and 31 December 2010. The following data were analysed: age at diagnosis, gender, anatomic site, race, socio-economic demographic (rural vs. urban), treatment protocol, side effects, viral characteristics and survival. All cases were confirmed by histology and reviewed by a tumour board. Results: A total of 51 patients with ...
Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn about Burkitt lymphoma.
Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn about Burkitt lymphoma.
Background. Between 1991 and 1997, limited funding at times restricted available treatment for children with Burkitt lymphoma (BL) to cyclophosphamide (CPM) monotherapy at Lilongwe Central Hospital, Malawi. Our objective was to assess long-term survival in Malawian children with Burkitt lymphoma (BL) who had received one or more treatments with intravenous CPM at 40 mg/kg/dose at 14-day intervals. Procedure and Results. The study population consisted of 92 children in whom BL had been confirmed on fine needle aspirates (FNA), a home address had been documented on discharge from hospital, and the treatment records could be verified. Only the clinical site(s) of disease had been recorded. The M:F ratio was 1.4 and median age 8 years. A clinical officer on motorcycle attempted to locate the given addresses and interview parents or other sources. In 19 patients, the address was incorrect. Of 73 evaluable patients, 40 children are alive at a mean follow-up time of 59 (range: 29-104) months. The ...
Shahzad Ali Jiskani, Asfa Zawar and Lubna Naseem. Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad. Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad. Abstract: Burkitt lymphoma is a disease of young population; especially children. It rarely occurs and presented in elderly group. World Heal Organization (WHO) divided Burkitt lymphoma in endemic, sporadic and immunodeficiency - associated. The non - endemic variant occur in children with abdominal involvement. We report a sporadic case presented at the age of 61 years old male with irregular thickening or parietal peritoneum and omentum without involving any lymph nodes. ...
Ruth was 9 years old when she first came to St Marys Hospital Lacor in Gulu. She is from a village in Lira, the district that borders Gulu in northern Uganda. Her father brought her to St Marys in June 2019 after she experienced a one-month history of progressive and painful abdominal swelling. When she was admitted to our hospital, Ruth was quite ill. Her nutritional status was very poor and she had severe wasting. Upon examination, she had a grossly distended abdomen and an ill-defined mass that was palpable and very large. She underwent blood work, a chest x-ray and an ultrasound of her abdomen. The ultrasound revealed that she had multiple tumors in her liver, a separate large mass within her abdominal cavity as well as fluid in the abdomen. A biopsy of the large abdominal mass was performed which confirmed that she had Burkitt lymphoma.. Ruth required supportive care, including nutritional support, and was started on first-line (FL) chemotherapy for Burkitt lymphoma that consisted of ...
Indeed, infection by Helicobacter pylori (H. pylori) has been recognized as a critical driver of mucosa-associated lymphoid tissue B-cell lymphoma, which is often reversible by antibiotic therapy. Likewise, chronic B-cell activation in the context of hepatitis C virus (HCV) infection was identified as a causative agent in the etiology of HCV-associated diffuse large B-cell lymphomas. Key evidence for this concept comes from a recent study on the role of Plasmodium falciparum (P. falciparum) in the etiology of endemic Burkitt lymphoma (5). In a genetic mouse model for chronic recurrent malaria infection, this study demonstrated that chronic B-cell activation in this model causes aberrant activation of AID and AID-mediated genomic instability leading to B-cell lymphoma. Of note, development of B-cell lymphoma in this model was critically dependent on protracted AID activity (somatic hypermutation and class-switch recombination) in the presence of plasmodium infection.. Initial genetic lesions ...
Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To elucidate molecular mechanisms regulating the development of apoptosis resistance, a panel of 15 BL cell lines was investigated for apoptosis induction upon treatment with microtubule inhibitors taxol, nocodazole and vincristine. Significant differences were observed in the extent of apoptosis induction among BL cell lines examined. Interestingly, cell lines exhibiting resistance to taxol- or nocodazole-induced apoptosis, showed development of polyploidy (,4N) and vice versa, displaying an inverse relationship between apoptosis and polyploidy induction. Further, in sensitive cell lines taxol-induced apoptosis was accompanied by caspase activation, Bid cleavage and Mcl-1 down-regulation. In contrast, most apoptosis resistant cell lines exhibited a loss of Bax and Bak expression and showed prolonged mitotic arrest with ,4N DNA content upon treatment. To gain mechanistic ...
In Burkitt lymphoma the c-myc gene, the cellular homologue of the viral oncogene v-myc, has been implicated in the aetiology of this human B-cell malignancy. Burkitt lymphoma cells possess specific chromosomal rearrangements involving the region proximal to the c-myc gene and one of the three human immunoglobulin loci. The nature of the effect exerted by the immunoglobulin loci on the translocated c-myc gene is controversial: whereas some reports have suggested c-myc transcription is elevated in Burkitt lymphoma cells, others have suggested the level of transcription is unaffected by the translation. Recently, transcription enhancer elements have been identified in the intron between the JH and C mu segments of the heavy-chain immunoglobulin gene in mice. If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. We report here the identification of an enhancer element adjacent to the human C mu
Epstein-Barr virus (EBV) has been causally associated with at least five human malignancies. The exact contributions made by EBV to these cancers remain unknown. We demonstrate that one viral protein found in all EBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitts lymphoma. Inhibition of EBNA-1 decreases survival of these tumor cells by inducing apoptosis. Expression of EBNA-1 in uninfected cells also can inhibit apoptosis induced by expression of p53 in the absence of the EBV genome. Our findings demonstrate that EBNA-1 is critical for the continued survival of EBV-associated Burkitts lymphoma, and, by extension, for the other B cell tumors with which EBV is associated. Efficient inhibitors of EBNA-1s functions would likely prove useful in the therapy of EBV-associated malignancies.
Zhou P, Newman AM, Van Noorden S, Banda K, Chagaluka G, Lampert I, Erhorn A, Bacon C, Bailey S, Molyneux E, Rand V. Investigation of prognostic markers in endemic Burkitt lymphoma. In: Fifth International Symposium on Childhood Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell Publishing Ltd ...
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression. We identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt lymphoma and regulated in the same direction by MYC in the model cell lines. Among them, we focused on a lncRNA that we named MYC-induced long noncoding RNA (MINCR), showing a strong correlation with MYC expression in MYC-positive lymphomas. To understand its cellular role, we performed RNAi and found that MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes ...
Buckle GC, Collins JP, Sumba PO, Nakalema B, Omenah D, Stiffler K, Casper C, Otieno JA, Orem J, Moormann AM. 2013. Factors influencing time to diagnosis and initiation of treatment of endemic Burkitt Lymphoma among children in Uganda and western Kenya: a cross-sectional survey.. Infectious agents and cancer. 8(1):36. Abstract ...
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitts lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable ...
SAL is a Gb3 (Galα1-4Galβ1-4Glc)-binding lectin with three SUEL-type lectin domains which was purified from catfish eggs. The lectin depleted expression of mRNA coding multidrug resistant protein, MRP1, time- and dose-dependently through binding with Gb3 glycosphingolipid which is highly expressed on human Burkitts lymphoma Raji cells. This interaction inhibited the excretion of chemotherapy drugs. The administration of vincristine could effectively killed Raji cells even at l/10 lower concentration than the lethal-doses, if co-treatment with SAL was conducted. The Japanese Association for Marine Biology (JAMBIO) in MEXT Japan identified this research as a leading edge topic as part of their 2012 research activities reporting. These results were possible through the work of Assist. Profs. Yuki Fujii (Nagasaki International University and adjunct researcher of Yokonama City University) and Shigeki Sugawara (Tohoku Pharmaceutical University), Assoc. Prof. Sarkar M. Abe Kawsar (University of ...
Impaired apoptosis is considered a prerequisite for the development of most, if not all, cancers, but the mechanisms that guarantee sustained survival of most cancer cells remain unknown. Members of the BCL-2 family of proteins are key regulators of apoptosis and include proteins essential for cell survival and those required to initiate cell death. Studies with transgenic mice have shown that over-expression of BCL-2 or related pro-survival family proteins, such as BCL-XL or MCL-1, can promote tumorigenesis, particularly in conjunction with mutations that deregulate cell cycle control, such as deregulated c-MYC expression. It is, however, not known whether expression of pro-survival BCL-2 family members under endogenous control is required to maintain survival of cells undergoing neoplastic transformation. Using Eµ-Myc transgenic mice, a well-characterized model of human Burkitts lymphoma, and other murine cancer models, we investigated the role of BCL-2 pro-survival proteins when expressed ...
In raising murine hybridoma antibodies against Epstein-Barr virus (EBV)-induced membrane antigens (MA), we found one antibody that blocked the release of infectious EBV from cultured P3HR-1 cells. This monoclonal antibody (mAb) recognized a 200 kD, phosphonoacetic acid-sensitive (late) MA, and did not directly neutralize virus without complement. When this mAb was added to 33 degrees C-cultured, spontaneously EBV-producing P3HR-1 cells, the intracellular expression of viral capsid antigen and infectious virus was not inhibited, but the appearance of infectious virus in the culture medium was significantly reduced. The duration of this suppression was dependent upon the concentration of the mAb, an effect being observed to a 1:4 X 10(5) titer of the ascites mAb preparation. A more acute effect of suppression of EBV release was observed in a second model of 12-o-tetradecanoyl phorbol-13-acetate and n-butyrate induction of EBV in 37 degrees C-cultured P3HR-1 cells. Again, intracellular infectious ...
Endemic Burkitt is highly associated with EBV infection. , 30% of sporadic Burkitt lymphomas are EBV positive.. HIV-associated Burkitt is associated with HIV or other causes of immunodeficiency.. Epidemiology:. Endemic Burkitt lymphoma is endemic to equatorial Africa and South America. The sporadic and endemic types are more common in children while the HIV-associated type is more common in adults.. Clinical features:. Sporadic Burkitt often presents as an abdominal mass. It can be a cause for ileus. Endemic Burkitt usually presents as a mass in the maxilla or mandibula.. Pathology:. The tumor cells have very high rate of proliferation, and apoptosis is widespread. Tingible body macrophages phagocytose the apoptotic bodies, which causes the starry sky pattern on histology.. Treatment:. Burkitt tumours are highly chemosensitive. Patients with large tumours are at increased risk for tumor lysis syndrome.. ...
TY - JOUR. T1 - Adult high-grade B-cell lymphoma with Burkitt lymphoma signature. T2 - Genomic features and potential therapeutic targets. AU - Bouska, Alyssa. AU - Bi, Chengfeng. AU - Lone, Waseem. AU - Zhang, Weiwei. AU - Kedwaii, Ambreen. AU - Heavican, Tayla. AU - Lachel, Cynthia M.. AU - Yu, Jiayu. AU - Ferro, Roberto. AU - Eldorghamy, Nanees. AU - Greiner, Timothy Charles. AU - Vose, Julie Marie. AU - Weisenburger, Dennis D.. AU - Gascoyne, Randy D.. AU - Rosenwald, Andreas. AU - Ott, German. AU - Campo, Elias. AU - Rimsza, Lisa M.. AU - Jaffe, Elaine S.. AU - Braziel, Rita M.. AU - Siebert, Reiner. AU - Miles, Rodney R.. AU - Dave, Sandeep. AU - Reddy, Anupama. AU - Delabie, Jan. AU - Staudt, Louis M.. AU - Song, Joo Y.. AU - McKeithan, Timothy W.. AU - Fu, Kai. AU - Green, Michael. AU - Chan, Wing C.. AU - Iqbal, Javeed. PY - 2017/10/19. Y1 - 2017/10/19. N2 - The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma (BL) are highly aggressivelymphomas with ...
The Epstein-Barr Virus Capsid Antigen (VCA) IgM ELISA Kit is intended for the measurement of IgM antibodies to Epstein-Barr Virus Capsid Antigen (VCA) in a sample. This kit utilizes Epstein-Barr VCA antigen (P3H3 cell extract, cultured in human Burkitt lymphoma cells).
en] Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitts lymphoma. This is a rare location of sporadic Burkitts lymphoma with neurologic syndrome as first symptoms ...
Mild hyperthermia is known to enhance apoptosis in a range of normal and neoplastic cell populations. Studies of tumours previously shown to respond to heating in this manner might be expected to provide insights not only into the mechanism of hyperthermic cell killing, but also into the apoptotic process in general. In the present study, cell death induced by 43°C heating for 30 min in two human Burkitts lymphoma lines, BM 13674 and WW1, and in murine mastocytoma P‐815 × 2·1 was found to be exclusively apoptotic in type, identification being based on light and electron microscopic appearances and on the presence of internucleosomal cleavage of DNA into fragments that are multiples of 180-200 base pairs, which was demonstrated by agarose gel electrophoresis. The heat‐induced apoptosis was prevented by the presence of zinc sulphate, an inhibitor of the endonuclease considered to be responsible for the DNA cleavage, but was not suppressed by the protein synthesis inhibitor cycloheximide. ...
Piperlongumine (PL), a pepper plant alkaloid from Piper longum, kills solid tumor cells in a highly selective, potent fashion. To evaluate whether PL may have similar effects on malignant blood cells, we determined the efficacy with which PL inhibits the B-lymphocyte derived neoplasm, Burkitt lymphoma (BL). Low micromolar concentrations of PL (IC50=2.8μM×8.5μM) curbed growth and survival of two EBV+ BL cell lines (Daudi, Raji) and two EBV BL cell lines (Ramos, DG-75), but left normal peripheral blood B-lymphocytes unharmed. PL-dependent cytotoxicity was effected in part by reduced NF-κB and MYC activity, with the former being caused by inhibition of IκBα degradation, nuclear translocation of p65, and binding of NF-κB dimers to cognate DNA sequences in gene promoters. In 4 of 4 BL cell lines, the NF-κB/MYC-regulated cellular target genes, E2F1 and MYB, were down regulated, while the stress sensor gene, GADD45B, was up regulated. The EBV-encoded oncogene, LMP-1, was suppressed in Daudi and ...
Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and to determine the importance of these mechanisms in a translational system moving from a mouse model to human malaria. The most frequently cited immunological consequences of malaria are: suppression of vaccine responses, susceptibility to bacterial infection, susceptibility to endemic Burkitt lymphoma, and increased HIV viral load. Of these, susceptibility to non-Typhoid Salmonella (NTS) bacteremia, associated with severe hemolysis, was the most consistent between animal and human studies. I hypothesized that hemolysis would induce the immunomodulatory enzyme heme oxygenase-l (HO-l), which is essential for survival in malaria infections in mice, but might impair host defence against NTS. I demonstrate in mice that malaria, chemically-induced ...
A bispecific monoclonal antibody is made up of two different monoclonal antibodies that bind to two different substances and kills cancer cells. Bispecific monoclonal antibody therapy is used in the treatment of Burkitt and Burkitt-like lymphoma/leukemia and diffuse large B-cell lymphoma.. Tyrosine kinase inhibitors (TKIs) block signals that tumors need to grow. Some TKIs also keep tumors from growing by preventing the growth of new blood vessels to the tumors. Other types of kinase inhibitors, such as crizotinib, are being studied for childhood non-Hodgkin lymphoma.. Immunotoxins can bind to cancer cells and kill them. Denileukin diftitox is an immunotoxin used to treat cutaneous T-cell lymphoma.. Targeted therapy is being studied for the treatment of childhood non-Hodgkin lymphoma that has recurred (come back).. See Drugs Approved for Non-Hodgkin Lymphoma for more information.. Other drug therapy. Retinoids are drugs related to vitamin A. Retinoid therapy with bexarotene is used to treat ...
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
BACKGROUND: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic … phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. METHODS: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and ...
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
Burkitt-like post-transplant lymphoproliferative disorder (PTLD) presenting with breast mass in a renal transplant recipient: a report of a rare case. Law, Man; Chan, Hay; Leung, Charlotte; Lai, Ho; Ha, Chung; Ng, Celia; Yeung, Yiu; Yip, Sze // Annals of Hematology;Dec2014, Vol. 93 Issue 12, p2083 A letter to the editor is presented in response to the article which discusses the Burkitt-like post-transplant lymphoproliferative disorder (PTLD) with breast mass in a renal transplant recipient that was published in the one of the previous issue of the periodical. ...
Burkitts lymphoma, Burkitts tumor A form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma. The Epstein-Barr virus (EB virus), a gammaherpes virus, has been isolated from Burkitts lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans. Also known as Burkitts Lymphoma ...
Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. Epstein-Barr virus (EBV) and malaria are epidemiologically linked to endemic BL in epidemiologic studies, but questions remain about role of EBV variants and the evidence for association with malaria is weak. EBV is ubiquitous, yet only few children develop BL, possibly because only a few EBV variants are pathogenitically relevant. The association of BL with malaria is based on ecologic and non-comparative clinical studies. Two case-control studies have reported significant association of high anti-malarial antibodies with BL (OR=5_ among children in Uganda and in Malawi, but selection bias (cases and controls came from dissimilar geographical areas) and reverse causality bias were limitations. Three studies were conducted in the 1960s and 70s to test association of carriage of malaria-resistance gene with ...
Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. Epstein-Barr virus (EBV) and malaria are epidemiologically linked to endemic BL in epidemiologic studies, but questions remain about role of EBV variants and the evidence for association with malaria is weak. EBV is ubiquitous, yet only few children develop BL, possibly because only a few EBV variants are pathogenitically relevant. The association of BL with malaria is based on ecologic and non-comparative clinical studies. Two case-control studies have reported significant association of high anti-malarial antibodies with BL (OR=5_ among children in Uganda and in Malawi, but selection bias (cases and controls came from dissimilar geographical areas) and reverse causality bias were limitations. Three studies were conducted in the 1960s and 70s to test association of carriage of malaria-resistance gene with ...
Denis Parsons Burkitt FRS (28 February 1911 - 23 March 1993), surgeon, was born in Enniskillen, County Fermanagh, Ireland. He was the son of James Parsons Burkitt, a civil engineer. Aged eleven he lost his right eye in an accident. He attended Portora Royal School in Enniskillen and Dean Close School, England. In 1929 Burkitt entered Trinity College, Dublin, to study engineering, but believing his evangelical calling was to be a doctor, he transferred to medicine. In 1938 he passed the Edinburgh Royal College of Surgeons fellowship examinations. On 28 July 1943 he married Olive Rogers. During World War II, Burkitt served with the Royal Army Medical Corps in England and later in Kenya and Somaliland. After the war, Burkitt decided his future lay in medical service in the developing world and he moved to Uganda. He eventually settled in Kampala and remained there until 1964. Burkitt made two major contributions to medical science related to his experience in Africa. The first was the description, ...
Looking for online definition of Burkitts lymphoma in the Medical Dictionary? Burkitts lymphoma explanation free. What is Burkitts lymphoma? Meaning of Burkitts lymphoma medical term. What does Burkitts lymphoma mean?
Updated cell lines for exosome production includes also HEK293 cell line (Human Embryonic Kidney cells 293). Lyophilized and purified exosomes from cell culture medium. • PC3 cell line (human prostate adenocarcinoma grade IV) • BPH-1 cell line (human being prostatic hyperplasia) • DAUDI cell line (human burkitt lymphoma) • A549 cell line (lung carcinoma) • K-562 cell line (pleural effusion, leukemia chronic myelogenous) • B16F10 mouse cell line (mouse melanoma cell line) • HEK293 cell line (human embryonic kidney) Lyophilized Exosome Standards. Lyophilization is the ideal technique for preserving the long-term stability of exosomes at 4 .. Lyophilized exosomes can be used as control standards for multiple applications including FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.. Lyophilized exosomes are easy to ship and store, and are stable for 12 months at 4 . Purified and lyophilized exosomes are obtained from a ...
The virus in the EB-3 cell line derived from a Burkitt lymphoma was partially purified by digestion with proteolytic enzyme and by density-gradient centrifugation on potassium tartrate. Electron microscope studies of both sectioned and negatively stained samples suggest that the virus belongs to the herpes-virus group, although the exact number of capsomeres was not unequivocally established. ...
Burkitt Lymphoma Treatment Market Analysis 2021: Industry Growth Factors, Types, Applications, Top Players, Regional Insights To 2027
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Burkitt lymphoma
Incorporation of thalidomide, lenalidomide, and pomalidomide into the myeloma therapeutic armamentarium has contributed substantially to patient survival. Given the contributory role, EBV plays in approximately 50% of Hodgkin lymphoma, and reports of Hodgkin lymphoma in patients on lenalidomide-MT, we hypothesized that lenalidomide, and its analogues thalidomide and pomalidomide, may induce EBV reactivation. This hypothesis was further supported by the fact that the immunosuppressant methotrexate in nonmalignant diseases such as rheumatoid arthritis enhanced the risk of EBV-positive lymphomas (9). In this study, we found that LTP reactivated EBV in latently infected B-cell lines in the order of efficacy pomalidomide , lenalidomide , thalidomide. LCL cells were weakly inducible into lytic cycle, whereas Burkitt lymphoma cells were readily induced (Fig. 1). Combinations of ganciclovir with lenalidomide or pomalidomide enhanced the growth inhibitory effect in Burkitt lymphoma cells (Fig. 2C and ...
Eighty-four patients fulfilling the 1987 ACR criteria for RA and 22 patients with rheumatic conditions other than RA were studied. Sixty-nine healthy controls were chosen from bone marrow donors at the Marseille blood transfusion center. HLA-DR genotyping of patients and controls was performed by PCR-SSP. Real-time PCR was performed using a Roche LightCycler. A 214-bp fragment from the highly conserved long internal repeat IR1 was amplified. Two specific hybridization probes were used to recognize adjacent internal sequences within the target. EBV-positive Burkitts lymphoma cell line was used as an external standard. ...
Database of prospective cohort of Burkitt lymphoma patients at Kamuzu Central Hospital, Lilongwe, Malawi. Manuscript published in Blood Advances; Painschab, et al., 2019. ABSTRACT Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL is highly curable with chemotherapy. However, there are few prospective studies from SSA describing non-pediatric BL and no regional standard of care. Thirty-five participants aged ≥15 years with newly diagnosed BL from 2013-2018 in Malawi were enrolled. Chemotherapy was administered according to local institutional guidelines, with concurrent antiretroviral therapy (ART) if HIV-infected. Median age was 21 (range 15-61) and 15 (43%) participants were HIV-infected. Twenty-seven (77%) participants had stage III/IV disease and 19 (54%) had ECOG performance status (PS) |1. Among HIV-infected, median CD4 count was 130 (range 29-605), and ten (67%) had suppressed HIV viral load. Four (11%) patients died before chemotherapy initiation. First
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Induction of Epstein-Barr Virus Lytic Replication Beth Israel Deaconess Medical Center, Boston, Dr. Joyce Fingeroth Student Presenter: Anastasia Hyrina Project Advisor: Craig Woodard Epstein-Barr virus (EBV) is a member of the herpesvirus family and is one of the most common human viruses. In the United States, 95% of adults between 35 and 40 years of age have been infected with EBV1. EBV is the etiological agent of infectious mononucleosis and is associated with a number of diverse lymphomas and epithelial cancers, including African Burkitts lymphoma, nasopharyngeal carcinoma and gastric malignancies2. Though EBV primarily infects B lymphocytes and epithelial cells, the sequence of infection is not well understood. In infected B cells, EBV establishes persistent latent infections. The latent state of the virus in a cell is characterized by expression of a small subset of viral genes and the latent membrane proteins, which are essential for induction and maintenance of cellular proliferation ...
BL occurs as an Epstein-Barr virus (EBV) associated malignancy among children in the malaria belt of equatorial Africa (endemic BL),5 and sporadically in other geographical areas, where it also occurs among adults (sporadic BL).6,7 The most common site of involvement of endemic BL is the kidneys. Jaw tumours are age related with an overall incidence in Uganda of 50%.7 In contrast, the terminal ileum and lymph nodes are the more commonly involved sites in sporadic BL.8,9 A common translocation t(8;14) and the consequent c-myc rearrangement and overexpression have been identified in endemic and sporadic BL. However, some not very strict associations between JH and DH recombination have been identified at 14q32, with distant 5 c-myc recombination in endemic cases of BL, whereas in sporadic cases Sμ and Sα recombination was identified10 at 14q32, with near 5 or intronic c-myc recombination at 8q24. These differences between endemic and sporadic BL do not mean that each of these subtypes of ...
Read the Burkitt surname history and see the family crest, coat of arms for the English Origin. Discover the Burkitt surname history. Where did the name Burkitt come from?
Background During B-cell development, precursor B-cells transiently express the pre-B-cell receptor composed of μ heavy chain complexed with VpreB and λ5 surrogate light chain polypeptides. Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B-cells and Burkitt lymphoma. Design and Methods Here, we used a novel antibody to investigate the normal expression pattern of VpreB3 protein in human hematolymphoid tissues, and determine whether VpreB3 can serve as a useful diagnostic biomarker for select B-cell lymphomas. Results We found that VpreB3 protein is normally expressed by precursor B-cells in bone marrow and by a subset of normal germinal center B-cells in secondary lymphoid organs. Among lymphoid malignancies, we found an association between VpreB3 expression and B-cell tumors with c-MYC abnormalities. VpreB3 was highly expressed in all cases of Burkitt lymphoma, whether of endemic or sporadic origin (44/44 ...
The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitts lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.
1. Dang C V. MYC on the Path to Cancer. Cell. 2012;149(1):22-35 2. Fernandez PC, Frank S R, Wang L. et al. Genomic targets of the human c-Myc protein. Genes & development. 2003;17(9):1115-1129 3. Li Z, Van Calcar S, Qu C. et al. A global transcriptional regulatory role for c-Myc in Burkitts lymphoma cell. PNAS. 2003;100(14):8164-8169 4. Lin CY, Lovén J, Rahl PB. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151(1):56-67 5. Zhang X, Zhao X, Fiskus W. et al. Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas. Cancer cell. 2012;22(4):506-523 6. Berg T. Small-molecule modulators of c-Myc/Max and Max/Max interaction. Curr Top Microbio Immunol. 2011;348:139-149 7. Lin CP, Liu CR, Lee CN. et al. Targeting c-Myc as a novel approach for hepatocellular carcinoma. World J Hepatol. 2010;2(1):16-20 8. Zhang W, Kater AP, Widhopf GF. et al. B-cell activating factor and v-Myc ...
Free, official coding info for 2021 ICD-10-CM C83.78 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Free, official coding info for 2018 ICD-10-CM C83.76 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
The boy is reported having high-dose chemo, with all possible accompanying effects, anyway, hes fighting, and it seems the situation is not getting worse. ...
(1911-1993) British surgeon Born in Enniskillen, now in Northern Ireland, Burkitt attended Dublin University, receiving his BA in 1933 and MB in 1935. Having become a fellow of Edinburgh s Royal College of Surgeons in 1938, Burkitt served in the…
al.. Superman and Captain America. Two strong characters, no doubt about that. These are the nicknames I gave two little premature infant boys I had helped take care of in the neonatal ICU spring 2007. Watching these tiny guys fight for their lives, grow, and go through various trials was routine to me. It was not routine for their mom and dad. I gave them these nicknames for fun. One day the mother asks me why I call Hagan Superman. I said, because he had strength he didnt even know he had.. I became ill January 14th, 2008 on a Monday evening at church. I felt the distinct feeling of the flu: fever, chills, and cold to the bone. The next morning, I felt better and went to work. Driving on I-30, pain began in my lower back. The pain was on the move and increased quickly. I thought I was having a heart attack. I went to the nearest ER and was admitted. 7 days in a hospital revealed I was healthy except for an elevated white blood cell count. No diagnosis was given other than ...
A) EBV infection makes the malarial parasite able to produce lymphoma. B) Malarias strain on the immune system makes EBV infection worse. C) Malaria occurs
The VIM gene was one of many that Gieser and Swaroop (1992) recovered from a subtracted cDNA library for retinal pigment epithelium. Vimentin gene express in human lymphocytes and in Burkitts lymphoma cells. Vimentin is secreted by activated macrophages. The gene encoding human vimentin is located on the short arm of chromosome 10.. ...
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For a balanced presentation, it is important to discuss the evidence in favor of the somatic-mutation theory. We present seven arguments used to support the somatic mutation theory and offer some alternative explanations related to the theory that the initiating event is a disruption of the morphostat gradient which then may be followed by genetic instability. The first four arguments rely on a recent review article on oncogenes and cancer [38] from which we quote extensively.. (1) The first evidence that cancer arises from somatic genetic alterations came from studies of Burkitts lymphoma, in which one of three different translocations juxtaposes an oncogene, MYC.... Since every malignant lymphocyte carries the MYC translocation, deregulation of the MYC oncogene is probably the initiating event [38]. An alternative interpretation is that the MYC translocation indicates a late-stage event in carcinogenesis after the disruption of the morphostat gradient.. (2) Second, transfection experiments ...
The incidence of AIDS-defining malignancies (ADMs) and NADMs has undergone a variety of changes in the ART era. Rates of ADMs, including NHL, have largely fallen [2-6], although within NHL there is an increasing proportion of Burkitt lymphomas [6, 7]. Additionally, the reported rates of HL, an NADM, have remained constant [4, 8-11] or increased [2, 3, 12-14]. Regardless, the risk for NHL and HL remains greater than for the general population [3, 15, 16]. For instance, the standardized incidence ratio of NHL in HIV-infected individuals from 1996 to 2002 was 22.6 [95% CI 20.8-24.6], as compared with that of the general population enrolled in the Surveillance, Epidemiology, and End Results Program registry [3]. In the Center for AIDS Research Network of Integrated Clinical Systems cohort, among incident cancer cases diagnosed in ART-treated patients from 1996 to 2009, NHL comprised 18%, primary central nervous systemNHL 3%, and HL 5% [17]. While hematologic malignancies did not represent ...
Dr. Mutyaba has had multiple training opportunities with Fred Hutch Global Oncology. First, he was an HIV-Associated Malignancy fellow between 2009-2010, where he took graduate classes at the University of Washington Schools of Medicine and Public Health and participated in clinical rotations at the Seattle Cancer Care Alliance. Dr. Mutyaba conducted research to understand the relationship between the use of antiretroviral therapy and cancer incidence in Uganda. After returning to Uganda, he became Global Oncologys Burkitt Lymphoma Project Study Coordinator and matriculated the Master of Medicine program at Makerere University (expected award date of January 2016). In March 2011, he became Global Oncologys first Ugandan fellow to receive independent funding through a two-year startup catalytic grant, Beginning Investigator Grant for Catalytic Research (BIG Cat), from the African Organization for Research and Training in Cancer (AORTIC) and National Cancer Institute. He presented his research ...
Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet. 2012 Dec; 44(12):1316-20 ...
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... causing excessive proliferation observed as Burkitt's lymphoma. Burkitt's lymphoma commonly affects the jaw bone, forming a ... Burkitt's lymphoma is a type of Non-Hodgkin's lymphoma and is most common in equatorial Africa and is co-existent with the ... Nasopharyngeal cancer Several Non-Hodgkin's lymphomas, including Burkitt's lymphoma and primary cerebral lymphoma Post- ... Burkitt's lymphoma, and Epstein Barr virus positive diffuse large B-cell lymphoma, not otherwise specified); 2) non-lymphoid ...
MAOA Burkitt's lymphoma; 113970; MYC Buschke-Ollendorff syndrome; 166700; LEMD3 C syndrome; 211750; CD96 C5 deficiency; 609536 ... FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin's lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; ...
"Peter Saint John". Burkitt's Lymphoma Society. 2013. Archived from the original on June 9, 2017. Retrieved June 9, 2017. "In ...
Burkitt, D. P. (1971). "Epidemiology of Burkitt's Lymphoma". Proceedings of the Royal Society of Medicine. 64 (9): 909-910. doi ... Other notable work included relating the incidence of Burkitt's lymphoma to climatic conditions and the discovery of several ... Haddow's most prominent work was considered to be that on yellow fever and Burkitt's lymphoma. The Zika virus has since emerged ...
Peng SL, Cheng CN, Chang KC (2007). "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682-3. doi: ...
Burkitt lymphoma (BL); Hodgkin lymphoma (HL); plasmablastic lymphoma (PBL); and primary effusion lymphoma (PEL) (also termed ... Burkitt lymphoma occurs in three forms. Epidemic Burkitt lymphoma (eBL) is common in Africa, the Middle East, Brazil, Papua New ... Two extremely rare types of the intravascular lymphomas, intravascular NK-cell lymphoma and intravascular T- cell lymphoma, are ... angioimmunoblastic T-cell lymphoma (AITL), and anaplastic lymphoma kinase positive or negative anaplastic large-cell lymphoma ( ...
Denis Parsons Burkitt first describes Burkitt's lymphoma. February 7 - Discovery of "Deep Skull" in Niah Caves in Sarawak by ... synd/2511 at Who Named It? Burkitt, D. (1958). "A sarcoma involving the jaws in African children". The British Journal of ...
Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma). Non-coding RNAs (ncRNAs) have a role in this process. ... of endemic Burkitt's lymphoma. Splicing of these W repeat transcripts produces a short intron and a long intron (Fig. 1), both ... "An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt ...
Anthony Yeo, 60, Singaporean counsellor, Burkitt's lymphoma. Gilda Galán, 92, Puerto Rican actress. Lorena Gale, 51, Canadian ... Alan Berkman, 63, American physician and activist, lymphoma. Fleur Cowles, 101, American writer, editor and artist. Baciro Dabó ... Bob Bogle, 75, American guitarist (The Ventures), non-Hodgkin lymphoma. Angela Coughlan, 56, Canadian swimmer, bronze medalist ... Luo Jing, 48, Chinese news presenter, lymphoma. Adilgerei Magomedtagirov, 53, Russian general, Interior Minister for the ...
Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt's lymphoma samples by ... Epstein, M.A; Achong, B.G; Barr, Y.M (1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". The Lancet. ... Epstein, Anthony (2012-03-01). "Burkitt lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology. 156 ... "Morphological and Biological Studies on a Virus in Cultured Lymphoblasts from Burkitt's Lymphoma". Journal of Experimental ...
Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...
... she was treated for Burkitt's lymphoma. She was treated with aggressive chemotherapy including intrathecal chemotherapy at City ... The cause of lymphoma was prior chemotherapy from 2008 for breast cancer. In 2013, Gujral was in remission from both cancers. ... Lisa Tsering (2013-08-06). "Actress fights lymphoma Urges Community Awareness". India West. Archived from the original on 2013- ...
Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964-03-28). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma". ...
Overexpression of QSER1 was noted in Burkitt's Lymphoma. QSER1 expression also increases with increasing Gleason score (more ... Altered expression of QSER1 is noted in pathological cardiomyopathy, Burkitt's Lymphoma, prostate cancer, and some breast ...
Nick Venet, 61, American record producer, Burkitt's lymphoma. Wayne Ambler, 82, American baseball player. Eddie Campagnuolo, 70 ... Sally Purcell, 53, British poet and translator, lymphoma of brain cells. Mae Questel, 89, American actress, Alzheimer's disease ...
In 1964 Anthony Epstein, Bert Achong and Yvonne Barr identified the first human oncovirus from Burkitt's lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... Infectious causes of cancer Carcinogen Oncogenic Oncogene Adult T-cell leukemia/lymphoma Cancer bacteria Oncolytic virus, a ... B-cell non-Hodgkin's lymphoma, and cancer". World Journal of Hepatology. 7 (3): 327-43. doi:10.4254/wjh.v7.i3.327. ISSN 1948- ...
EBV has also been implicated in several other diseases, including Burkitt's lymphoma, Hodgkin's lymphoma, stomach cancer, ... 2014). "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... and hydroa vacciniforme as well as malignant lymphoproliferative diseases such as Epstein-Barr virus-positive Burkitt lymphoma ...
... primary leptomeningeal lymphoma, diffuse large cell lymphoma,[non-primary source needed] MALT lymphoma, and Burkitt's lymphoma ... Shimano S, Murata N, Tsuchiya J (July 1997). "[Idiopathic CD4+ T-lymphocytopenia terminating in Burkitt's lymphoma]". Rinsho ... Campbell JK, Prince HM, Juneja SK, Seymour JF, Slavin M (April 2001). "Diffuse large cell lymphoma and t(8;22) (q24;q11) in a ... Lymphoma. 41 (3-4): 421-3. doi:10.3109/10428190109057998. PMID 11378556. S2CID 23366810. Longo F, Hébuterne X, Michiels JF, ...
He was the first to describe a type of cancer that now bears his name Burkitt's lymphoma. This type of cancer was endemic in ... ISBN 978-1-904455-03-5. Bornkamm GW (April 2009). "Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more ... Magrath I (September 2009). "Lessons from clinical trials in African Burkitt lymphoma". Current Opinion in Oncology. 21 (5): ... In an attempt to find a cause for the cancer, Burkitt sent cells from the tumour to Anthony Epstein (b. 1921) a British ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Burkitt's lymphoma, Hodgkin's lymphoma, Post-transplant lymphoproliferative disease and Nasopharyngeal carcinoma.[52]. ... 1964: Anthony Epstein, Bert Achong and Yvonne Barr identify the first human oncovirus from Burkitt lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...
He died on 2 January 1998 of Burkitt's lymphoma. He is survived by his wife, actress Valerie Kairys Venet, and their son, ...
In February 2012, Couchey was diagnosed with Burkitt's lymphoma. The aggressive cancer took hold quickly, and Couchey died on ...
The most frequently discussed example of c-Myc as a proto-oncogene is its implication in Burkitt's lymphoma. In Burkitt's ... A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...
Report of two cases, one simulating a Burkitt lymphoma". Acta Cytol. 34 (2): 265-8. PMID 2157324.CS1 maint: multiple names: ... Tumour cells in peripheral blood may look similar to circulating blasts or lymphoma cells. Features that aid in distinguishing ... megakaryocytes or osteoclasts Leukemoid reaction Lymphoma The presence of tumour cells in the peripheral blood of a cancer ...
CS1 maint: discouraged parameter (link) Epstein, A. (2012). "Burkitt Lymphoma and the discovery of Epstein-Barr virus". British ... Epstein was the first person to propose that Burkitt's lymphoma was a cancer caused by a virus. Upon hearing a lecture given by ... changed his research focus from cancer causing viruses in chickens to searching for a viral origin of Burkitt's lymphoma. After ... more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from them ...
... gene was first discovered in Burkitt lymphoma patients. In Burkitt lymphoma, cancer cells show chromosomal translocations, ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ... and tumorigenicity in Burkitt's lymphoma". Current Topics in Microbiology and Immunology. 258: 153-60. PMID 11443860.. ...
Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... EBV has also been implicated in several other diseases, including Burkitt's lymphoma,[42] Hodgkin's lymphoma,[43] stomach ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and Cancer. 9 ( ...
Also seen in chronic lymphocytic leukemia, Hodgkin's Lymphoma, Burkitt's Lymphoma. Carbone PP, Kaplan HS, Musshoff K, Smithers ... B symptoms are a clear negative prognostic factor in Hodgkin lymphoma. The relevance of B symptoms in non-Hodgkin lymphoma is ... and weight loss which can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. The presence or absence of B ... B symptoms are so called because Ann Arbor staging of lymphomas includes both a number (I-IV) and a letter (A or B). "A" ...
C. O. Povlsen, J. Rygaard: Effects of Cyclophosphamide (Endoxan R) on a Burkitt´s Lymphoma serially grown in nude mice. In: ... Mit der Behandlung des bei der Nacktmaus transplantierten Burkitt-Lymphoms wurde 1974 erstmals ein neuer Weg in der ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...
Burkitt's lymphoma ... B-cell lymphoma - B cells - B lymphocytes (B cells) - ... non-Hodgkin's lymphoma (NHL) - non-nucleoside reverse transcriptase inhibitors (NNRTI) - non-steroidal anti-inflammatory drugs ...
Daniels VG, Wheater PR, Burkitt HG (1979). Functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone. ... Of the various tumors of the blood and lymph, cancers of WBCs can be broadly classified as leukemias and lymphomas, although ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...
2002). "EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma". Curr. Top. Microbiol. Immunol. 258: 153-60. ... Iijima S, Teraoka H, Date T, Tsukada K (1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation ... initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas". ...
Rochford, Rosemary; Moormann, Ann M. (2015). «Burkitt's Lymphoma». Epstein Barr Virus Volume 1. Current Topics in Microbiology ... Burkitt-lymfekreft eller Burkitt-lymfom er ein lymfekreft frå B-seller. Sjukdomen er i mange tilfelle knytt til både Epstein- ... Casulo, Carla; Friedberg, Jonathan (2015). «Treating Burkitt Lymphoma in Adults». Current Hematologic Malignancy Reports 10 (3 ... Burkitt-lymfekreft vart fyrst skildra av den britiske kirurgen Dennis Burkitt i 1958 frå pasientar i Kampala i Uganda. Epstein- ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...
B21.1) HIV disease resulting in Burkitt's lymphoma. *(B21.2) HIV disease resulting in other types of non-Hodgkin's lymphoma ...
Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... mature B-cell ALL (Burkitt leukemia - FAB L3) An extensive panel of monoclonal antibodies to cell surface markers, particularly ... Infectious mononucleosis, acute myeloid leukemia, lymphoblastic lymphoma, aplastic anemia[3]. Treatment. Chemotherapy, stem ... August 2005). "Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas". ...
On May 30, 2007, Andruzzi was diagnosed with non-Hodgkin's Burkitt's lymphoma, predicted to double in size in just 24 hours.[1] ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... of all cases of lymphomas in HIV infections (other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... a b Primary CNS Lymphoma~treatment at eMedicine *^ Omuro, A; et al. (26 February 2015). "R-MPV followed by high-dose ...
Ruf IK, Rhyne PW, Yang H, et al., EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma, in Curr. Top. ... Iijima S, Teraoka H, Date T, Tsukada K, DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc ... Il gene Myc fu scoperto per la prima volta in pazienti affetti da linfoma di Burkitt. In questa neoplasia le cellule tumorali ... initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas, in ...
Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ... and lymphoma) before age five have been established. However, further research is needed to confirm these findings. Little is ...
Denis Parsons Burkitt (1911-1993), doctor, discoverer of Burkitt's lymphoma. *Roy Carroll (born 1977), association footballer ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ... and lymphoma) before age five have been established. Little is currently known about how paternal smoking damages the fetus, ...
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...
Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... "HCV syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin's lymphoma, and cancer ...
Kræftformerne B-celle lymphoma, T-celle lymphoma, Hodgkin lymphoma, Burkitt's lymphoma, mavekræft og nasopharyngeal carcinoma ...
伯基特淋巴瘤(英语:Burkitt's lymphoma). 霍奇金淋巴瘤. 濾泡性樹突狀細胞肉瘤(英语:Follicular dendritic cell sarcoma). Extranodal NK/T-cell lymphoma, nasal ... 脾邊緣淋巴瘤(英语:Splenic marginal zone lymphoma). 人類嗜T淋巴球病毒一型 成人T細胞白血病/淋巴瘤(英语:Adult T-cell leukemia/lymphoma). ... type(英语:Extranodal NK/T
Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...
Burkitt's lymphoma. *Burn-Goodship syndrome. *Burnett-Schwartz-Berberian syndrome. *Burning mouth syndrome- Type 3 ...
Angioimmunoblastic T-cell lymphoma. *B-cell prolymphocytic leukemia. *Burkitt's lymphoma. *Chronic lymphocytic leukemia ... Lymphoma and leukemia: These two classes of cancer arise from cells that make blood. Leukemia is the most common type of cancer ... in children accounting for about 30%.[2] However, far more adults develop lymphoma and leukemia. ...
... potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo". Cancer Biology & Therapy. 4 (5 ...
Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...
Burkitt's lymphoma, Primary central nervous system lymphoma) · MCPyV (Merkel cell cancer) · SV40 ... RNA virus: HCV (Hepatocellular carcinoma) · HTLV-I (Adult T-cell leukemia/lymphoma) ...
"A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells". Proceedings of the National Academy of ...
Burkitts lymphoma. Hodgkins lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ... Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Unique genetic alterations promote cell survival in Burkitt lymphoma, distinct from other types of lymphoma.[21] These TCF3 and ...
... is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B-cell lymphoma or small noncleaved cell lymphoma. ... Burkitts lymphoma. Definition. Burkitts lymphoma (BL) is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B- ... Non-Hodgkins lymphoma (NHL). -One of two major subdivisions of lymphomas. Burkitts lymphoma is a subcategory of NHL. ... Burkitts lymphoma was first described in 1957 by Denis Parsons Burkitt, an Irish surgeon. While this type of lymphoma is still ...
recognized as the fastest growing human tumor, burkitt lymphoma is associated with impaired ... burkitt lymphoma is a form of non-hodgkins lymphoma in which cancer starts in immune cells called b-cells. ... What is Burkitt lymphoma?. ANSWER Burkitt lymphoma is a form of non-Hodgkins lymphoma in which cancer starts in immune cells ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ...
if burkitt lymphoma is suspected, all or part of an enlarged lymph node or other suspicious disease site will be biopsied. in a ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... How is Burkitt lymphoma diagnosed?. ANSWER If Burkitt lymphoma is suspected, all or part of an enlarged lymph node or other ...
Histology of Burkitts lymphoma.. Br Med J 1971; 1 doi: https://doi.org/10.1136/bmj.1.5750.669-a (Published 20 March 1971) Cite ...
Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis. Burkitt lymphoma can be divided into three main ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ... Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Non-Hodgkin lymphoma, which includes Burkitt, accounts for 30-50% of childhood lymphoma. The jaw is less commonly involved, ...
Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, Virginia Three cases of Burkitts lymphoma (BL) have occurred ... editorial note: Burkitts lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it ... Brubaker G, Geser A, Pike MC: Burkitts lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of ... Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of American Burkitts Lymphoma in neighbors. N Engl J Med 288: ...
Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn ... Burkitt-like lymphoma is grouped with Burkitt lymphoma.. Subtypes of Burkitt lymphoma. There are 3 subtypes of Burkitt lymphoma ... Burkitt lymphoma. Burkitt lymphoma is a type of mature B-cell non-Hodgkin lymphoma (NHL). Burkitt lymphoma develops most often ... Sporadic Burkitt lymphoma is also called non-African, or non-endemic, Burkitt lymphoma. It is the most common type of Burkitt ...
Learn about the survival rates of non-Hodgkin lymphoma cancer in children including lymphoblastic, Burkitt, and large cell ... Burkitt and Burkitt-like lymphoma Treatment of limited stage (stage I and II) Burkitt lymphomas is usually very successful, ... The long-term survival rate for children with more advanced (stage III or IV) Burkitt lymphoma ranges from about 80% to 90%. ... Large cell lymphomas The long-term survival rate is over 90% for limited stage (stage I and II) diffuse large B-cell lymphomas ...
D. Burkitt, "Burkitts lymphoma outside the known endemic areas of Africa and New Guinea," International Journal of Cancer, vol ... Orbital Burkitts Lymphoma: An Aggressive Presentation. Gian Paolo Giuliari,1,2,3 Ama Sadaka,4 Maria Angelica Cortez,1,3 and ... D. Burkitt and G. T. OConor, "Malignant lymphoma in African children. I. A clinical syndrome," Cancer, vol. 14, pp. 258-269, ... I. K. Ruf, P. W. Rhyne, H. Yang et al., "Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma ...
... a non-Hodgkins lymphoma of B cell origin that occurs especially in children of central Africa and is associated with Epstein- ... Comments on Burkitts lymphoma. What made you want to look up Burkitts lymphoma? Please tell us where you read or heard it ( ... Time Traveler for Burkitts lymphoma. The first known use of Burkitts lymphoma was in 1963. See more words from the same year ... History and Etymology for Burkitts lymphoma. Denis Parsons Burkitt †1993 British surgeon ...
Duodenal involvement of Burkitt lymphoma is extremely rare and accounts for , 1% of all lymphomas. We present a case report of ... Burkitt lymphoma is a malignancy that has commonly presented in GI tract but rarely in the duodenum. This clinical variant can ... Most non-Hodgkin lymphoma tumors involve extra nodal sites like the nervous system and gastrointestinal tract. A rare variant ... an older patient with a duodenal Burkitt lymphoma diagnosed by biopsy. A high suspicion should be present while treating ...
Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult ... Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas. Burkitts lymphoma: single-centre experience with modified ... Overview of Burkitts Lymphoma. ABOUT Lymphomas:. Overview of genes and cancer. Lymphoma is a cancer. About Lymphoma - general ... Burkitt-like lymphoma of T-cell type ncbi.nlm.nih.gov The Burkitt-like lymphomas bloodjournal.hematologylibrary.org. Southwest ...
in children, in the jaw, eyes, and internal organs: it is associated with the Epstein-Barr virusOrigin of Burkitts ... Burkitts lymphoma definition: a cancer characterized by tumors containing lymphoid cells, occurring esp. ... Burkitts lymphoma. Bur·kitts lymphoma. a cancer characterized by tumors containing lymphoid cells, occurring esp. in children ... "Burkitt\s lymphoma." YourDictionary, n.d. Web. 19 January 2019. ,https://www.yourdictionary.com/burkitt-s-lymphoma,. ...
Microgeographic variations in Burkitts lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr ... Microgeographic variations in Burkitts lymphoma. Study Abstract. BACKGROUND:. Endemic Burkitts lymphoma (eBL) has been ... Microgeographic variations in Burkitts lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr ...
A Ugandan autopsy specimen from a 4 year old african girl admitted with tumour of the jaw. She died two days after admission. The specimen shows extensive destruction by soft,haemorrhagic tumour of both mandibular rami with extension into the adjacent soft tissues. Tumour was also present in the liver, thyroid, spleen, kidneys, ovaries and abdominal lymph nodes.
Burkitts lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the ... Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.. Schmitz R1, Young RM, Ceribelli ... Targeted therapies: New targets in Burkitt lymphoma? [Nat Rev Clin Oncol. 2012] ... a, Fre quencies of TCF3 and ID3 mutations in different lymphoma subtypes. b, TCF3 missense mutations in the E47 isoform in BL, ...
Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. It causes the cells in the lymphatic system to ... Burkitt Lymphoma. Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. It causes the cells in the ... Molecular Epidemiology to Detect Tumor Precursors in Children at Risk for Endemic Burkitts Lymphoma ... The Impact Of CD56neg NK Cells in the Pathogenesis of Endemic Burkitt Lymphoma ...
PubMed journal article Burkitts lymphoma: clinicopathologic features and differential diagnosi were found in PRIME PubMed. ... Burkitts type in the Working Formulation, Burkitts lymphoma and high-grade B-cell lymphoma, Burkitt-like in the REAL ... Burkitts type in the Working Formulation, Burkitts lymphoma and high-grade B-cell lymphoma, Burkitt-like in the REAL ... Burkitts lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in ...
Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To ... Apoptoseresistenz ist einer der Gründe für ein Versagen von Chemotherapie bei vielen Krebserkrankungen, darunter das Burkitt ... Um die molekularen Mechanismen der Apoptoseresistenz aufzuklären, wurde die Apoptoseinduktion in 15 Burkitt-Lymphom-Zelllinien ... könnten eine weitere Möglichkeit zur Behandlung von resistenten Burkitt-Lymphomen darstellen.. ...
... type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. The disease may affect the jaw, ... There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). Sporadic Burkitt lymphoma ... and endemic Burkitt lymphoma occurs in Africa. Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients. ... Burkitt lymphoma listen (BER-kit lim-FOH-muh) An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most ...
... or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by ... the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, ... encoded search term (Burkitt%20Lymphoma%20and%20Burkitt-like%20Lymphoma) and Burkitt Lymphoma and Burkitt-like Lymphoma What to ... Burkitt Lymphoma and Burkitt-like Lymphoma. Updated: Apr 08, 2016 * Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD ...
2006 issue concerning the molecular diagnosis of Burkitts lymphoma, almost half the patients with Burkitts lymphoma were ... Diagnosis of Burkitts lymphoma in due time: a practical approach. Cogliatti, S. B.; Novak, U.; Henz, S.; Schmid, U.; Möller, P ... Genomic Diagnosis of Burkitts Lymphoma. Lin, Bryan T. // New England Journal of Medicine;9/7/2006, Vol. 355 Issue 10, p1064 A ... Genomic Diagnosis of Burkitts Lymphoma. Dave, Sandeep S.; Staudt, Louis M. // New England Journal of Medicine;9/7/2006, Vol. ...
Lymphoma. *Non-Hodgkin lymphoma. *Non-Hodgkin lymphoma diagnosis. *Non-Hodgkin lymphoma treatment. *Non-Hodgkin lymphoma ... "Our research focuses on a group of lymphomas driven by abnormal expression of a gene called MYC of which Burkitts lymphoma is ... "We have found that Burkitts lymphoma cells are highly dependent on a pro-survival protein called MCL-1 and that if we take ... "We hope our research will really help to progress the search for alternatives for patients with Burkitts lymphoma who are ...
Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times ... The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as ... A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody ... A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody ...
Primary CNS involvement in Burkitts lymphoma is rare.. Keywords. Brain Mediastinum Cavernous sinus Burkitts lymphoma MRI ... Kalina P, Black K, Woldenberg R (1996) Burkitts lymphoma of the skull base presenting as cavernous sinus syndrome in early ... We report on this case because radiologists and clinicians should be alerted to identify sites of primary Burkitts lymphoma ... Burkitts lymphoma with bilateral cavernous sinus and mediastinal involvement in a child. ...
Burkitt lymphoma causing colocolonic intussusception. DISCUSSION. Burkitts lymphoma is a malignant, rapidly growing B-cell ... Intussusception caused by Burkitt lymphoma is extremely rare. However, Burkitt lymphoma is the most common cause of ... Burkitt lymphoma also encases the mesenteric vessels.2 The vascular encasement in Burkitt lymphoma differs from encasement seen ... Surgical resection of Burkitt lymphoma is not typically performed unless the entire mass can be resected or if the mass is ...
As such, Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults. The disease ... Burkitt lymphoma. What every physician needs to know:. Burkitt Lymphoma is a rapidly progressive lymphoid malignancy requiring ... Other non-Hodgkin lymphoma (NHL) histologies need to be differentiated from Burkitt lymphoma. Diffuse large B-cell lymphoma ( ... Are you sure your patient has Burkitt lymphoma? What should you expect to find?. The endemic variant of Burkitt lymphoma ...
... known as lymphomas. DCEGs work includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its ... known as lymphomas. DCEGs portfolio includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its ... Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) A large, multidisciplinary epidemiological effort ... Pooled Analysis of Studies of Non-Hodgkin Lymphoma A pooled analysis of case-control studies of non-Hodgkin lymphoma among men ...
  • [1] [2] The overall cure rate for Burkitt's lymphoma in developed countries is about 90%, but worse in low-income countries. (wikipedia.org)
  • Burkitt's lymphoma is uncommon in adults, where it has a worse prognosis . (wikipedia.org)
  • Burkitt's lymphoma (BL) is a type of non-Hodgkin's lymphoma (NHL) that is sometimes called a B-cell lymphoma or small noncleaved cell lymphoma. (encyclopedia.com)
  • Burkitt's lymphoma is one of the most rapidly growing forms of human cancer. (encyclopedia.com)
  • Burkitt's lymphoma was first described in 1957 by Denis Parsons Burkitt, an Irish surgeon. (encyclopedia.com)
  • The endemic form of Burkitt's lymphoma is characterized by rapid enlargement of the patient's jaw, loosening of the teeth, protruding eyeballs, or an abdominal tumor in the region of the kidneys or ovaries. (encyclopedia.com)
  • In adults, Burkitt's lymphoma frequently produces a bulky abdomen and may involve the liver, spleen, and bone marrow . (encyclopedia.com)
  • In Western countries, Burkitt's lymphoma is more common in male than in female children. (encyclopedia.com)
  • Between 40% and 50% of these cases are Burkitt's lymphoma. (encyclopedia.com)
  • In adults, Burkitt's lymphoma is again more common in males than in females. (encyclopedia.com)
  • Currently, about 2% of AIDS patients develop Burkitt's lymphoma. (encyclopedia.com)
  • Burkitt's lymphoma affects a part of the immune system known as the lymphatic or lymphoid system. (encyclopedia.com)
  • Burkitt's lymphoma involves the B-cell lymphocytes. (encyclopedia.com)
  • In 1982, researchers discovered an oncogene (a gene that can release cells from growth constraints, possibly converting them into tumors) in 90% of patients with Burkitt's lymphoma. (encyclopedia.com)
  • In the summer of 2000, researchers reported that a gene called the HMG-I/Y gene is also involved in the development of Burkitt's lymphoma. (encyclopedia.com)
  • In addition to translocations of genetic material, Burkitt's lymphoma is also associated with oncogenic viruses - the Epstein-Barr virus (EBV) in endemic Burkitt's and human immunodeficiency virus ( HIV ) in the sporadic form. (encyclopedia.com)
  • Currently, however, the precise role of EBV in Burkitt's lymphoma is still being investigated, because the virus is less common in patients outside Africa. (encyclopedia.com)
  • Histology of Burkitt's lymphoma. (bmj.com)
  • McClatchie S . Histology of Burkitt's lymphoma. (bmj.com)
  • Three cases of Burkitt's lymphoma (BL) have occurred since 1971 in young boys living in one residential section of Winchester, Virginia. (cdc.gov)
  • editorial note: Burkitt's lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it constitutes the most common tumor of childhood (2). (cdc.gov)
  • Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of 'American Burkitt's Lymphoma' in neighbors. (cdc.gov)
  • Brubaker G, Geser A, Pike MC: Burkitt's lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of time-space clustering in a high risk isolated rural area. (cdc.gov)
  • However, the almost ubiquitous presence of the virus in the epidemic variant of Burkitt's lymphoma suggests that it contributes to the development and/or progression of this variant. (wikipedia.org)
  • What made you want to look up Burkitt's lymphoma ? (merriam-webster.com)
  • Burkitt's lymphoma tends to occur most often in children and in adults with compromised immune systems. (lymphomation.org)
  • A novel approach to Burkitt's lymphoma, using a regimen designed for large B-cell lymphomas, led to complete remissions in all patients in a small study, investigators reported here. (lymphomation.org)
  • In a study of 19 patients with Burkitt's, the highly aggressive B-cell lymphoma, all 19 treated with dose-adjusted EPOCH with Rituxan (rituximab) had a complete remission, with few of the adverse events associated with standard chemotherapy for Burkitt's lymphoma, reported Kieron Dunleavy, M.D., of the National Cancer Institute in Bethesda, Md., and colleagues. (lymphomation.org)
  • An international evaluation of CODOX-M and CODOX-M alternating with IVAC in adult Burkitt's lymphoma: results of United Kingdom Lymphoma Group LY06 study. (lymphomation.org)
  • Endemic Burkitt's lymphoma (eBL) has been associated with Epstein-Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. (wellnessresources.com)
  • Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus. (wellnessresources.com)
  • Burkitt's lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL in developing countries, necessitating new strategies. (nih.gov)
  • Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (unboundmedicine.com)
  • Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. (unboundmedicine.com)
  • With the publication of the WHO Classification of Haematopoietic and Lymphoid Tumors, the nomenclature of this lymphoma has come full circle, and it is once again known simply as Burkitt's lymphoma. (unboundmedicine.com)
  • These efforts have led to the development of high-intensity, short-duration combination chemotherapy that has proven extremely effective for a high proportion of Burkitt's lymphoma patients. (unboundmedicine.com)
  • The differential diagnosis of Burkitt's lymphoma is broad, and precise diagnosis based on histologic, immunophenotypic, and genetic features remains the critical first step in planning appropriate therapy. (unboundmedicine.com)
  • TY - JOUR T1 - Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (unboundmedicine.com)
  • A1 - Ferry,Judith A, PY - 2006/4/15/pubmed PY - 2006/9/29/medline PY - 2006/4/15/entrez SP - 375 EP - 83 JF - The oncologist JO - Oncologist VL - 11 IS - 4 N2 - Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. (unboundmedicine.com)
  • An abstract of the article "Burkitt's Lymphoma of the Colon" by Ziad Salem, William DiGiacomo, and Joseph R. DePasquale is presented. (ebscohost.com)
  • Genomic Diagnosis of Burkitt's Lymphoma. (ebscohost.com)
  • A letter to the editor is presented in response to an article by Dave et al, published in the June 8, 2006 issue concerning the molecular diagnosis of Burkitt's lymphoma, almost half the patients with Burkitt's lymphoma were children. (ebscohost.com)
  • A letter to the editor is presented in response to comments on a study regarding the genomic diagnosis of Burkitt's lymphoma. (ebscohost.com)
  • Burkitt's lymphoma--Winchester, Virginia. (ebscohost.com)
  • Reports on three cases of Burkitt's lymphoma (BL) which have occurred since 1971 in young boys living in Winchester, Virginia. (ebscohost.com)
  • Raji revisited: cytogenetics of the original Burkitt's lymphoma cell line. (ebscohost.com)
  • Presents a letter to the editor on the cytogenics of the original Burkitt's lymphoma cell line. (ebscohost.com)
  • Diagnosis of Burkitt's lymphoma in due time: a practical approach. (ebscohost.com)
  • An abstract of the medical research presentation "Diagnosis of Burkitt's lymphoma in due time: a practical approach," by S. B. Cogliatti, U. Novak, S. Henz, U. Schmid, P. Möller and T. F. E. Barth is presented. (ebscohost.com)
  • The curious case of the tumour virus: 50 years of Burkitt's lymphoma. (ebscohost.com)
  • A correction to the article "The Curious Case of the Tumour Virus: 50 Years of Burkitt's Lymphoma," by David A. Thorley-Lawson and Martin J. Allday is presented. (ebscohost.com)
  • The Leukaemia Foundation is funding research aimed at advancing treatment for a blood cancer called Burkitt's lymphoma (BL) , thanks to the generous support of a major donor who has survived this aggressive blood cancer. (leukaemia.org.au)
  • Our research focuses on a group of lymphomas driven by abnormal expression of a gene called MYC of which Burkitt's lymphoma is the most well-known example," said Dr Kelly. (leukaemia.org.au)
  • We have found that Burkitt's lymphoma cells are highly dependent on a pro-survival protein called MCL-1 and that if we take this protein away using genetic tricks in the laboratory, the lymphoma cells die very rapidly. (leukaemia.org.au)
  • More recently, we have tested the efficiency of a drug that targets MCL-1 in our pre-clinical models of lymphomas and found it to be very efficient at killing Burkitt's lymphoma cells, and the side-effects to healthy tissues appeared manageable," she said. (leukaemia.org.au)
  • We now want to generate pre-clinical models that allow us to test how efficient pharmacological MCl-1 inhibition is in primary biopsy samples from Burkitt's lymphoma patients and patients with other MYC-driven lymphomas and leukaemias ," said Dr Kelly. (leukaemia.org.au)
  • We hope our research will really help to progress the search for alternatives for patients with Burkitt's lymphoma who are unable to tolerate chemotherapy and those who relapse with this disease" said Dr Kelly. (leukaemia.org.au)
  • Biopsy of the mediastinal lesion identified Burkitt's lymphoma. (springer.com)
  • We report on this case because radiologists and clinicians should be alerted to identify sites of primary Burkitt's lymphoma outside of the central nervous system if clinical symptoms indicate, or imaging shows, CNS lesions. (springer.com)
  • Primary CNS involvement in Burkitt's lymphoma is rare. (springer.com)
  • Kalina P, Black K, Woldenberg R (1996) Burkitt's lymphoma of the skull base presenting as cavernous sinus syndrome in early childhood. (springer.com)
  • Burkitt's lymphoma is a malignant, rapidly growing B-cell neoplasm. (appliedradiology.com)
  • Burkitt's lymphoma (BL) is an aggressive blood cancer. (leukaemia.org.au)
  • Developing a novel anti-cancer drug for the treatment of aggressive Burkitt's Lymphoma is the title of their research project. (leukaemia.org.au)
  • Team Burkitt's Lymphoma 2017 is closed for new team members, but you can register for the event with a new team or join another team! (alexslemonade.org)
  • Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. (nih.gov)
  • S. Sariban-Sohraby, I. T. Magrath and R. S. Balaban, "Comparison of Energy Metabolism in Human Normal and Neoplastic (Burkitt's Lymphoma) Lymphoid Cells," Cancer Research, Vol. 43, No. 10, 1983, pp. 4662-4664. (scirp.org)
  • J. J. Glasheen and M. D. Sorensen, "Burkitt's Lymphoma Presenting with Lactic Acidosis and Hypoglycemia-A Case Presentation," Leukemia & Lymphoma, Vol. 46, No. 2, 2005, pp. 281-283. (scirp.org)
  • Side view of the face of a child showing a large tumour in the jaw due to Burkitt's lymphoma cancer. (sciencephoto.com)
  • Burkitt's lymphoma has a surprisingly large number of genetic mutations, a discovery that may speed treatment for this aggressive cancer that hits mainly African children. (nih.gov)
  • Burkitt's lymphoma is a particularly cruel disease, hitting mostly children and developing aggressively. (nih.gov)
  • This opens many doors for improved understanding and potential treatments of Burkitt's lymphoma. (nih.gov)
  • He noted that more effective treatments for Burkitt's lymphoma are needed especially in Africa. (nih.gov)
  • Lymphoblasts of two tissue culture strains (EB1 and EB2) from different biopsy specimens of Burkitt's lymphoma have been examined in thin sections by electron microscopy, and have each been found to carry a morphologically identical virus. (nih.gov)
  • Endemic Burkitt's lymphoma is the most frequent childhood cancer in Africa, commonly presenting with involvement of the abdominal viscera. (scielo.org.za)
  • Burkitt's lymphoma is one of the most common types of non-Hodgkin's lymphoma in childhood. (scielo.org.za)
  • [2] The World Health Organization classification stratifies Burkitt's lymphoma into endemic, sporadic and HIV-associated variants. (scielo.org.za)
  • Ultrasound-guided renal biopsy demonstrated a high-grade B-cell lymphoma, with morphological and immunophenotypic features consistent with a Burkitt's lymphoma. (scielo.org.za)
  • Endemic Burkitt's lymphoma classically presents with abdominal involvement, commonly bowel, nodal and secondary renal involvement. (scielo.org.za)
  • Burkitt's lymphoma has the highest incidence of renal involvement of the childhood lymphomas, usually in the terminal stage. (scielo.org.za)
  • Endemic Burkitt's lymphoma must be considered when a child presents with an abdominal mass in the African environment. (scielo.org.za)
  • This expedites treatment initiation, as Burkitt's lymphoma has a rapid tumour doubling time of less than 24 hours. (scielo.org.za)
  • A case of Burkitt's lymphoma in England. (springer.com)
  • Low-intensity therapy in adults with Burkitt's lymphoma. (springer.com)
  • Magrath IT, Lwanga S, Carswell W, Harrison N. Surgical reduction of tumour bulk in management of abdominal Burkitt's lymphoma. (springer.com)
  • Primary gastric Burkitt's lymphoma is a rare disease that belongs to the aggressive non-Hodgkin's lymphomas. (koreamed.org)
  • We report a case of primary gastric Burkitt's lymphoma in a 24-year-old female presenting with an intermittent epigastric pain for 3 months. (koreamed.org)
  • Burkitt's lymphoma: a child's case presenting in the maxilla. (biomedsearch.com)
  • Burkitt's lymphoma (BL) is a neoplasm which, despite its very aggressive behaviour is potentially curable. (biomedsearch.com)
  • Christopher Glass, communications officer for IMA World Health in New Windsor, is climbing Mount Kilimanjaro to raise money for Burkitt's lymphoma cancer awareness and research. (sun-sentinel.com)
  • His objective is to raise both awareness and funding to fight for Burkitt's lymphoma , a particularly aggressive form of childhood cancer for which IMA provides treatment in Tanzania and other Third World countries. (sun-sentinel.com)
  • Every dime he raises from sponsors and supporters will go toward treating kids with Burkitt's lymphoma. (sun-sentinel.com)
  • Burkitt's lymphoma (BL) is a rare malignancy arising from B-cells. (aacrjournals.org)
  • It has previously been reported that some salvage pathway enzymes are found on the surface of Burkitt's Lymphoma cells. (aacrjournals.org)
  • The potential surface presentation of HPRT was assessed using flow cytometry, scanning electron microscopy (SEM), and cytoplasmic staining on both healthy lymphocytes and Burkitt's Lymphoma cells (Raji). (aacrjournals.org)
  • These results suggest a direct relationship between HPRT and the surface of Burkitt's lymphoma cells, indicating HPRT as a potential target for future immunotherapeutic treatment in Burkitt's B-cell lymphoma pediatric patients. (aacrjournals.org)
  • Burkitt's lymphoma is a cancer of the lymph nodes which mostly affects children. (natural-homeremedies.com)
  • Not all Burkitt's lymphoma have viral origins. (natural-homeremedies.com)
  • If you are suffering from Burkitt's lymphoma then you should incorporate plenty of green leafy vegetables such as spinach, kale, Brussels sprouts and broccoli in your diet . (natural-homeremedies.com)
  • At this meeting I'll be talking about Burkitt's lymphoma, specifically I'll be talking about the EMBLEM study which is a study we designed to look at questions that were asked fifty years ago when Burkitt's lymphoma was discovered when malaria was hypothesised as a causal factor in Burkitt's lymphoma. (ecancer.org)
  • What we're doing in EMBLEM is a case control study where we get cases that have Burkitt's lymphoma and controls who are children who don't have Burkitt's lymphoma and then we are using a genomic approach because some people who have certain genotypes that protect them from malaria will have a lower burden of malaria in their lifetime. (ecancer.org)
  • So it will actually measure the relationship between malaria and Burkitt's lymphoma using this indirect approach. (ecancer.org)
  • So we'll be able to test our hypothesis that children who have genetic resistance to malaria will have a lower risk for Burkitt's lymphoma. (ecancer.org)
  • These include diagnosing cancer, especially Burkitt's lymphoma, so there has been an improvement in that area, we can tell you the number that we've diagnosed. (ecancer.org)
  • We've improved treatment of Burkitt's lymphoma, so provided protocol based treatments to the children who attend the hospitals which are participating with us and we are introducing what we call BL, Burkitt's lymphoma, community awareness campaigns. (ecancer.org)
  • These are simple, plain language posters that we can use to educate the community and health workers about Burkitt's lymphoma. (ecancer.org)
  • A little bit of history about Burkitt's lymphoma would be appropriate here. (ecancer.org)
  • In terms of diseases that we've discovered in the last fifty years, Burkitt's lymphoma was discovered in 1958, it has had a tremendous impact on science. (ecancer.org)
  • Burkitt's lymphoma (BL) cell lines carry a translocated c- myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. (aacrjournals.org)
  • The World Health Organisation classification reports three subcategories of Burkitt's lymphoma (BL)-endemic, non-endemic, and immunodeficiency associated-proposed to reflect the major clinical and genetic subtypes of this disease. (bmj.com)
  • 1 In 1961, the neoplasm was identified as a form of malignant lymphoma, and what had initially emerged as a clinical syndrome became a pathological entity called Burkitt's lymphoma (BL). (bmj.com)
  • Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. (jimmunol.org)
  • Fresh biopsy cells from cases of Burkitt's lymphoma (BL) display a homogeneous cell surface phenotype. (jimmunol.org)
  • Burkitt's lymphoma rarely presents as a primary of the ovary. (ajol.info)
  • There are a few case reports presented on ovarian Burkitt's lymphoma. (ajol.info)
  • Autopsy, concluded the cause of death to be widely disseminated Burkitt's lymphoma, with a most likely tubo-ovarian primary and intestinal obstruction. (ajol.info)
  • Burkitt's lymphoma should be considered as a differential diagnosis in ovarian masses for timely diagnosis and management. (ajol.info)
  • The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. (thefreedictionary.com)
  • Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. (thefreedictionary.com)
  • Background Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. (haematologica.org)
  • Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. (haematologica.org)
  • Design and Methods We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. (haematologica.org)
  • Results Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. (haematologica.org)
  • Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. (haematologica.org)
  • Conclusions Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. (haematologica.org)
  • Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy. (haematologica.org)
  • Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma characterized by specific morphological and immunophenotypic features, a high proliferation rate (Ki-67 index exceeding 90%) and, on the molecular level, by a chromosomal translocation involving the MYC oncogene. (haematologica.org)
  • The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt's lymphoma. (ac.be)
  • This is a rare location of sporadic Burkitt's lymphoma with neurologic syndrome as first symptoms. (ac.be)
  • Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitt's lymphoma cell line by a monoclonal antibody against a 200,000 dalton EBV membrane antigen. (rupress.org)
  • Burkitt's lymphoma in the elderly. (ecancer.org)
  • Burkitt's lymphoma is a disease that can frequently be cured using intensive chemotherapy when found in younger patients. (ecancer.org)
  • Antonello Pinto from Naples, you are one of the steering committee on this and I know one of the things you're interested in is Burkitt's lymphoma. (ecancer.org)
  • The problem is that up to a few years ago, the idea that an elderly patient may develop Burkitt's lymphoma was not universally accepted. (ecancer.org)
  • The reality is that although Burkitt's lymphoma is a rare tumour, it is about 2% of Non-Hodgkin's lymphoma, about one third of patients developing the sporadic form, not the African form of Burkitt's lymphoma. (ecancer.org)
  • AP More or less some 31% to 32% of patients developing sporadic Burkitt's lymphoma in the western world - I mean, the States and Europe - are older than 65 years. (ecancer.org)
  • I mean, treatment of Burkitt's lymphoma in elderly adults is still a mathematical need because if you simply treat those patients by applying the same product that you use for young adolescents, you may have responses in some patients but there is a serious risk of losing the others because of toxicity. (ecancer.org)
  • Burkitt's lymphoma is not a preventable disease. (healthtap.com)
  • We studied a group of 54 children with Burkitt's lymphoma from Southeastern Brazil, where epidemiological status of Burkitt's lymphoma is poorly understood. (haematologica.org)
  • Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt's lymphoma risk, may characterize Burkitt's lymphoma in Brazil. (haematologica.org)
  • Burkitt's lymphoma (BL) shows marked variation across different geographical regions with respect to age-specific incidence, primary tumor site and association with Epstein-Barr virus (EBV) infection, 1 which characterize the endemic (eBL) and sporadic (sBL) subtypes. (haematologica.org)
  • Marked, transient inhibition of expression of the Epstein-Barr virus latent membrane protein gene in Burkitt's lymphoma cell lines by electroporation. (asm.org)
  • Burkitt's Lymphoma (BL) is a rare, aggressive and fast growing human tumor and was the first human tumor to be associated with an Epstein-Barr Virus (EBV) [ 1 ]. (omicsonline.org)
  • BACKGROUND: The Epstein-Barr virus (EBV) is associated with lymphoid malignancies, including Burkitt's lymphoma (BL), and can transform human B cells in vitro. (uzh.ch)
  • Adult Burkitt's lymphoma emerged as an AIDS-defining condition in the 1980s. (ajol.info)
  • We describe a case of HIV-associated adult Burkitt's lymphoma diagnosed and treated with high-dose chemotherapy in our institution, complicated by unusual bilateral renal vein tumour thrombi and tumour lysis syndrome. (ajol.info)
  • Multiple liver masses were detected and a biopsy revealed Burkitt's lymphoma. (biomedcentral.com)
  • The tumor cells have a similar appearance to the cancer cells of classical endemic Burkitt lymphoma. (wikipedia.org)
  • Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are supposed to possess identical IgH genes. (wikipedia.org)
  • The tumor cells in Burkitt lymphoma generally strongly express markers of B cell differentiation (CD20, CD22, CD19), as well as CD10 and BCL6. (wikipedia.org)
  • The lymphoma is in only one place, either as a single tumor not in lymph nodes, or in lymph nodes in one part of the body (the neck, groin, underarm, etc. (cancer.org)
  • The lymphoma is more than one tumor and/or in more than one set of lymph nodes, all of which are either above or below the diaphragm (the thin breathing muscle that separates the chest and abdomen). (cancer.org)
  • But other factors can also affect a child's outlook, such as the location and size of the tumor(s), and how well the lymphoma responds to treatment . (cancer.org)
  • Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. (hindawi.com)
  • The endemic variant of Burkitt lymphoma observed in equatorial Africa - a rapidly progressive jaw or orbital tumor - is the most common presentation, occurring more frequently in young children. (renalandurologynews.com)
  • The following chapter sheds light on epidemiology, tumor biology, treatment options and prognosis of this lymphoma which has evolved from an enigmatic syndrome to a curable disease. (springer.com)
  • A case of a so-called "Burkitt tumor" in a Dutch boy. (springer.com)
  • In the case of Burkitt's lymphomas (BL), most current evidence indicates that the tumor requires the virus minimally to block apoptosis. (pubmedcentralcanada.ca)
  • For both cervical carcinomas carrying human papillomaviruses (HPV) and Burkitt's lymphomas carrying Epstein-Barr virus (EBV), inhibiting viral genes in cell culture induces cell death in the tumor derived cells [ 8 - 10 ]. (pubmedcentralcanada.ca)
  • There are cases with poor outcome caused by toxic effects of the therapy, tumor lysis syndrome or metastatic spread of lymphomas to the central nervous system. (aacrjournals.org)
  • However, as lymphomas are known to form metastases in several sites, the analysis of their metastatic behavior and the suppression of this by imipramine-blue treatment may have implications for other aggressive tumor types as well. (aacrjournals.org)
  • Nevertheless, there are cases of poor clinical outcome caused by the toxicity of the intensive chemotherapy, tumor lysis syndrome, or metastatic spread of lymphoma cells to the central nervous system ( 4-7 ). (aacrjournals.org)
  • Here, we demonstrated for the first time the overexpression of DNMT1 and DNMT3B in Burkitt lymphoma (BL) tumor samples (69% and 86%, respectively). (sigmaaldrich.com)
  • The first broad genetic landscape map of a Burkitt lymphoma tumor has identified 70 mutations, including several not previously associated with cancer and a new one that is unique to the disease. (oncologynurseadvisor.com)
  • Dave explained that this alteration alone may not cause cancer, but when it occurs along with the MYC gene mutations that are common in Burkitt lymphoma and other malignancies, it works like an accelerant to fuel tumor growth. (oncologynurseadvisor.com)
  • Called also African lymphoma and Burkitt's tumor . (thefreedictionary.com)
  • The underlying mechanism of action of CDBPA in Burkitt`s lymphoma was tested in vitro and its effect on tumor size and survival was tested in a NOD-scid mice model. (omicsonline.org)
  • The epidemic variant of Burkitt lymphoma (eBL) is in almost all cases associated with EBV infection. (wikipedia.org)
  • [ 1 ] Burkitt-like lymphoma (BLL) is considered to be a morphologic variant of Burkitt lymphoma. (medscape.com)
  • A morphologic variant of Burkitt lymphoma characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages. (mycancergenome.org)
  • It is named after Denis Parsons Burkitt , a surgeon who first described the disease in 1958 while working in equatorial Africa . (wikipedia.org)
  • Named after Denis Parsons Burkitt, a surgeon who first described the disease in 1956. (yourdictionary.com)
  • An abstract of the study "Insertion of IGH into MYC in Burkitt Lymphoma identified by sequential FISH on paraffin sections" is presented. (ebscohost.com)
  • Mark J. Roschewski, MD , of the National Cancer Institute, discusses phase II study findings that showed DA-EPOCH-R cures most adult patients with Burkitt lymphoma, irrespective of HIV status (Abstract 188). (ascopost.com)
  • They also have some features of diffuse large B-cell lymphoma (DLBCL) cells. (cancer.ca)
  • The normal germinal centre B cell is the presumed cell of origin for both BL and diffuse large B-cell lymphoma (DLBCL), yet gene expression analysis suggests that these malignancies may use different oncogenic pathways. (nih.gov)
  • a, CCND3 mutations in BL, GCB DLBCL, ABC DLBCL and follicular lymphoma (FL) are shown with respect to amino acid positions 250-292 of protein accession NP_001751. (nih.gov)
  • Diffuse large B-cell lymphoma (DLBCL) is the most common NHL and may have a MYC rearrangement in 5% of cases. (renalandurologynews.com)
  • Given the relative incidence of DLBCL, Burkitt lymphoma occurs less commonly in developed countries than MYC+ DLBCL. (renalandurologynews.com)
  • Cases with morphologic features intermediate between DLBCL and Burkitt lymphoma are termed "B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma" as per the current World Health Organization classification. (renalandurologynews.com)
  • 1 However, the characteristic immunophenotype of BL and MYC translocations can also be detected in a subset of diffuse large B-cell lymphomas (DLBCL) 2 making the distinction between these two entities sometimes problematic. (haematologica.org)
  • Based on the results of this study, investigators conclude that future studies are needed to determine how best to treat adult patients with Burkitt lymphoma and DLBCL who have involved CSF. (onclive.com)
  • These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. (wikipedia.org)
  • The most common types of high grade non-Hodgkin lymphoma are: Diffuse large B cell lymphoma (DLBCL) is a type of high-grade NHL which is the most common type of NHL worldwide at affecting 30-40 percent of all NHL cases. (wikipedia.org)
  • citation needed] For advanced diffuse large B cell lymphoma the standard therapy for patients with DLBCL is the combination use of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). (wikipedia.org)
  • While this type of lymphoma is still relatively rare in the United States , it is responsible for 50% of cancer deaths in children in Uganda and central Africa. (encyclopedia.com)
  • Endemic Burkitt lymphoma is also called African Burkitt lymphoma because it mainly occurs in Africa. (cancer.ca)
  • Endemic Burkitt lymphoma is seen among the young of equatorial Africa. (lymphomation.org)
  • Sporadic Burkitt lymphoma occurs throughout the world, and endemic Burkitt lymphoma occurs in Africa. (cancer.gov)
  • Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. (clinicaltrials.gov)
  • Epidemiology of Burkitt lymphoma in East African children and minors (EMBLEM) is a case-control study of 1500 BL cases and 3000 age-, sex- and residence-frequency matched controls we are proposing to conduct in East Africa. (clinicaltrials.gov)
  • Burkitt lymphoma is one of the most common childhood cancers in equatorial Africa. (globalgiving.org)
  • In 1958, Denis Burkitt reported the first cases of a "sarcoma" of the jaws in children from equatorial Africa, 1 discovering a disease which a few years later would be recognized as a very aggressive form of lymphoma, 2 universally known as Burkitt lymphoma (BL) ( Figure 1 ). (dovepress.com)
  • There is a low background incidence of BL worldwide (sBL), which is rarely associated with EBV and accounts for 1-2% of adult lymphoma in Western Europe and America, but eBL is associated with (EBV) in over 95% of cases and is predominant in the equatorial belt of Africa and other parts of the world where malaria is hyperendemic. (bmj.com)
  • a form of undifferentiated lymphoma , usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. (thefreedictionary.com)
  • Endemic Burkitt lymphoma is a form of cancer that accounts for up to 74% of malignant disorders in children in equatorial Africa. (bio-medicine.org)
  • Epstein-Barr virus (EBV) and malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. (uzh.ch)
  • Dr.Burkitt identified this disease in 1956 in children in Africa. (wikipedia.org)
  • In Africa, Burkitt lymphoma is common in children also infected by malaria and Epstein-Barr virus. (wikipedia.org)
  • Outside of Africa, Burkitt lymphoma is less common. (wikipedia.org)
  • The long-term survival rate is over 90% for limited stage (stage I and II) diffuse large B-cell lymphomas and is slightly lower for anaplastic large cell lymphomas. (cancer.org)
  • This study was the first complete sequence of a Burkitt lymphoma genome, plus genes from 59 additional Burkitt cases and 94 diffuse large B cell lymphomas, which share many of the same characteristics of Burkitt lymphoma. (oncologynurseadvisor.com)
  • Striking differences were found in the gene mutation pattern of Burkitt lymphomas compared with the diffuse large B cell lymphomas. (oncologynurseadvisor.com)
  • But if misdiagnosed and given the standard chemotherapy regimes for diffuse large B cell lymphomas, Burkitt lymphoma patients invariably relapse. (oncologynurseadvisor.com)
  • One of the newly identified gene mutations, ID3, appeared in 34% of the Burkitt cases, but was not evident in any of the diffuse large B cell lymphomas. (oncologynurseadvisor.com)
  • Sporadic Burkitt lymphoma is also called non-African, or non-endemic, Burkitt lymphoma. (cancer.ca)
  • Central nervous system involvement has been reported in up to one-third of patients, is typically associated with other sites of extranodal involvement, and appears more frequently in endemic Burkitt lymphoma. (renalandurologynews.com)
  • Termed endemic Burkitt lymphoma, the majority of cases are Epstein-Barr virus (EBV)-related. (renalandurologynews.com)
  • Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. (ajtmh.org)
  • This technique is useful since sometimes benign reactive processes (e.g. infectious mononucleosis) and malignant lymphoma can be difficult to distinguish. (wikipedia.org)
  • D. Burkitt and G. T. O'Conor, "Malignant lymphoma in African children. (hindawi.com)
  • Concepts about malignant lymphoma. (ebscohost.com)
  • Delpassand ES, Kirkpatrick JB (1988) Cavernous sinus syndrome as the presentation of malignant lymphoma. (springer.com)
  • a form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. (thefreedictionary.com)
  • Lactic acidosis is a rare complication of malignancies and is seen more frequently in high grade lymphoma and leukemia. (scirp.org)
  • Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma revealing one of the highest proliferation rates in malignancies. (springer.com)
  • We knew that Burkitt lymphoma is curable with dose-intensive chemotherapy, but that treatment can be acutely toxic for adult patients," lead study author Mark Roschewski, MD, senior clinician and clinical director of the Lymphoid Malignancies Branch at the National Cancer Institute, stated in a press release. (onclive.com)
  • Other lymphoma histologies, including lymphoblastic lymphoma and blastic mantle cell lymphoma, present in a similar fashion to sporadic Burkitt lymphoma in adults. (renalandurologynews.com)
  • Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. (nih.gov)
  • Access details on the publication of Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics from PubMed. (nih.gov)
  • Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. (sigmaaldrich.com)
  • Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). (hu-berlin.de)
  • The reactivation of p16 and p14 in our model and our ability to inhibit cell proliferation and induce apoptosis through the Rb- and p-53 pathways opens new prospects for the understanding and treatment of Burkitt lymphoma. (oncologynurseadvisor.com)
  • Exposure to Sonic or Indian Hedgehog or cyclopamine (SMO inhibitor) does not modulate GLI1 expression, cell proliferation, or apoptosis in most Burkitt lymphoma cell lines. (luriechildrens.org)
  • Inhibition of GLI1 by GANT61 increases apoptosis and reduces viability of some Burkitt lymphoma cells. (luriechildrens.org)
  • Discovery of an Apoptosis Inducing Ligand for Burkitt Lymphoma" by Carolyn Laymon, Kyla Bradylong et al. (calpoly.edu)
  • We demonstrated that CDBPA significantly reduced cell viability and induced apoptosis via the extrinsic and the intrinsic apoptotic pathways of Burkitts lymphoma cells without causing cell cycle arrest but reduction of the various phases. (omicsonline.org)
  • The 'starry sky' appearance of Burkitt lymphoma characterized by benign macrophages interspersed amoung a diffuse infiltration of monotonous malignant lymphocytes. (renalandurologynews.com)
  • Findings from an ongoing, multicenter, phase 2 study identified an alternative treatment to dose intense chemotherapy through dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab for adults with untreated Burkitt lymphoma and diffuse large B-cell lymphoma. (onclive.com)
  • Diffuse large B-cell lymphoma is the most common subtype as well as the most common type of Non-Hodgkin Lymphoma. (wikipedia.org)
  • Currently, Burkitt lymphoma can be divided into three main clinical variants: the endemic, the sporadic , and the immunodeficiency -associated variants. (wikipedia.org)
  • What's the purpose of clinical trials for lymphoma drugs and treatments? (webmd.com)
  • Burkitt and Burkitt-like lymphomas have a rapid and aggressive clinical course with frequent bone marrow and central nervous system (CNS) involvement. (medscape.com)
  • 2 While patients who present with intussusception as their first clinical sign are diagnosed earlier, this does not change the prognosis as patients with the sporadic form of Burkitt lymphoma have an excellent prognosis regardless of the staging of the disease. (appliedradiology.com)
  • Burkitt lymphoma (BL) is currently classified as one of three clinical variants: endemic BL, sporadic BL, and HIV-associated BL. (bcgsc.ca)
  • Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. (onmedica.com)
  • Clinical outcome of relapsed or refractory burkitt lymphoma and mature B-cell lymphoblastic leukemia in children and adolescents. (springer.com)
  • Carla Casulo, MD , of the James P. Wilmot Cancer Center, discusses findings on POD24 as a robust early clinical endpoint of poor survival in follicular lymphoma, using data from mor. (ascopost.com)
  • There is 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are completed or closed. (mycancergenome.org)
  • KMT2A, KMT2A-AFF1, and KMT2A-ELL are the most frequent gene inclusion criteria for atypical Burkitt/Burkitt-like lymphoma clinical trials [ 3 ]. (mycancergenome.org)
  • Nivolumab and varlilumab are the most common interventions in atypical Burkitt/Burkitt-like lymphoma clinical trials. (mycancergenome.org)
  • AFF1 is an inclusion eligibility criterion in 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are closed. (mycancergenome.org)
  • NRIP3 is an inclusion eligibility criterion in 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are closed. (mycancergenome.org)
  • J. Durig, W. Fiedler, M. de Wit, M. Steffen and D. Hossfeld, "Lactic Acidosis and Hypoglycemia in a Patient with High-Grade Non-Hodgkin's Lymphoma and Elevated Circulating TNF-a," Annals of Hematology, Vol. 72, No. 2, 1996, pp. 97-99. (scirp.org)
  • In a collaborative effort involving more than 16 institutions around the globe, researchers from the Simon Fraser University (SFU)'s Department of Molecular Biology and Biochemistry have refined the classification of a rare cancer called Burkitt lymphoma (BL). (sfu.ca)
  • The sporadic type of Burkitt lymphoma (also known as "non-African") is the most common variant found in places where malaria is not holoendemic . (wikipedia.org)
  • It is the most common type of Burkitt lymphoma in North American and European countries. (cancer.ca)
  • For the rarer cases of adults with Burkitt lymphoma, treatment-related toxicities remain a significant obstacle to treatment. (onclive.com)
  • Study confirms effective, less toxic alternative to standard treatment for adults with Burkitt lymphoma. (onclive.com)
  • A multi-center retrospective study of 557 newly diagnosed adults with Burkitt lymphoma over a 9-year period (2009-2018). (mdedge.com)
  • It often develops with chemotherapy for Burkitt lymphoma, so the healthcare team will take measures to prevent TLS before chemotherapy starts. (cancer.ca)
  • Ruth required supportive care, including nutritional support, and was started on first-line (FL) chemotherapy for Burkitt lymphoma that consisted of cyclophosphamide, vincristine, methotrexate and treatment to prevent the spread of disease to her central nervous system. (globalgiving.org)
  • All types of Burkitt lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations . (wikipedia.org)
  • Burkitt lymphoma, or small noncleaved cell lymphoma, is a highly aggressive B-cell non-Hodgkin lymphoma characterized by the translocation and deregulation of the c-myc gene on chromosome 8. (medscape.com)
  • Methylation of CpG islands in promoter gene regions is frequently observed in lymphomas. (sigmaaldrich.com)
  • That finding could prove helpful for developing a new drug to function like a normal ID3 gene and suppress cancer cell proliferation in lymphomas as well as numerous other cancers. (oncologynurseadvisor.com)
  • Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines. (asm.org)
  • No unusual local patterns of leukemia, lymphoma, or infectious mononucleosis incidence were found, and no other persons with childhood cancer were identified as having been in contact with the patients or being in their particular neighborhood. (cdc.gov)
  • In developed countries where sporadic cases are most commonly encountered, Burkitt lymphoma can occur at any age, although the peak incidence is in the first decade of life. (renalandurologynews.com)
  • Meningeal involvement in non-Hodgkin's lymphoma: symptoms, incidence, risk factors and treatment. (springer.com)
  • Burkitt lymphoma is a rare disease with an incidence rate of approximately 0.2, which means that 2 individuals within a population of 1 million are affected by Burkitt lymphoma per year ( 2 ). (aacrjournals.org)
  • Because of the low incidence of the disease, research on novel drugs for Burkitt lymphoma treatment proceeds only slowly. (aacrjournals.org)
  • Before highly active antiretroviral therapy (HAART) became a widespread treatment for HIV/AIDS, the incidence of Burkitt lymphoma was estimated to be 1,000 times higher in HIV-positive people than in the general population. (wikipedia.org)
  • [4] Non-Hodgkin lymphoma, which includes Burkitt's, accounts for 30-50% of childhood lymphoma. (wikipedia.org)
  • Childhood Non-Hodgkin Lymphoma Treatment. (cancer.org)
  • Kamdar KY, Sandlund JT, Bollard CM. Malignant lymphomas in childhood. (cancer.org)
  • Ceyhan M, Erdem G, Kanra G, et al (1994) Lymphoma with bilateral cavernous sinus involvement in early childhood. (springer.com)
  • Sporadic BL is the most common type (30-40%) of childhood non-Hodgkin lymphoma. (clinicaladvisor.com)
  • Letter: childhood lymphoma resembling Burkitt's tumour in the southern Argentine. (bmj.com)
  • AP We are very successful in treating and curing this lymphoma in childhood and young adolescence with very intensive chemotherapy regimes which are based on the rapid recycling of drugs and on a very aggressive CNS directed treatment, because this lymphoma typically involves the central nervous system. (ecancer.org)
  • In the United States , the non-Hodgkin's lymphomas as a group account for about 7% of cancers in persons under 20 years of age. (encyclopedia.com)
  • Epstein-Barr virus is associated with an increased risk of certain cancers, including Burkitt lymphoma. (cancer.ca)
  • But when it comes to children with non-Hodgkin lymphoma (NHL), those who are still alive and free of lymphoma after 5 years are very likely to have been cured, as it's rare for these cancers to return after this much time. (cancer.org)
  • DCEG researchers conduct studies and participate in consortial activities on cancers of the white blood cells, known as lymphomas. (cancer.gov)
  • These proteins are implicated in 70% of all cancers, including leukaemia and lymphoma. (leukaemia.org.au)
  • This project helps to improve survival rates through the training of doctors and nurses in the management of children, not only with Burkitt lymphoma, but with other cancers, too. (globalgiving.org)
  • The analysis identified 70 genes that were frequently mutated in the Burkitt lymphomas, including a number of genes that were identified in cancer for the first time. (oncologynurseadvisor.com)
  • To study the cell type specificity of the direction of replication of the human c-myc genes and the relationship of replication polarity to transcriptional activity, we analyzed the directions of replication of the c-myc genes in two Burkitt lymphoma cell lines, CA46 and ST486, and in HeLa cells. (asm.org)
  • Burkitt lymphoma is a cancer of the lymphatic system , particularly B lymphocytes found in the germinal center . (wikipedia.org)
  • Burkitt lymphoma is a form of non-Hodgkin's lymphoma in which cancer starts in immune cells called B-cells. (webmd.com)
  • If more than 25% of the bone marrow is made up of cancer cells, called blasts , the cancer is classified as acute lymphoblastic leukemia [ALL] instead of lymphoma. (cancer.org)
  • 2016. Accessed at www.cancer.gov/types/lymphoma/hp/child-nhl-treatment-pdq on June 8, 2017. (cancer.org)
  • I work in the Blood Cells and Blood Cancer Division, headed by Professor Strasser, and we are trying to understand the control of the pathways to cell death with the objective of manipulating them specifically with therapeutics to make lymphoma cells die. (leukaemia.org.au)
  • If cancer cells are genetically engineered in the laboratory to remove the MCL-1 protein, the lymphoma cells die very rapidly. (leukaemia.org.au)
  • This finding identified MCL-1 as a therapeutic target for these particular lymphoma cells and now research is focusing on understanding the normal pathways that control cell death with the goal to manipulate this process to selectively kill cancer cells. (leukaemia.org.au)
  • The study was initiated by the Foundation for Burkitt Lymphoma Research based in Switzerland and funded in partnership with the National Cancer Institute (HHSN261200800001E) with salary support from the Terry Fox Research Institute. (sfu.ca)
  • Dr. Louis M. Staudt of the NIH's National Cancer Institute and his colleagues conducted genetic sequencing with high-capacity technology, which allowed them to quickly identify likely mutations that may cause the lymphoma. (nih.gov)
  • Read the article A Conversation with Dr. Louis Staudt about Targeting New Treatments for Burkitt Lymphoma from the September 4, 2012 issue of the National Cancer Institute Cancer Bulletin . (nih.gov)
  • Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251. (springer.com)
  • Burkitt lymphoma is a fatal cancer if left untreated. (globalgiving.org)
  • The International Network for Cancer Treatment and Research (INCTR) has designed a simple treatment plan for Burkitt lymphoma that can be safely delivered in African hospitals. (globalgiving.org)
  • Dr Mbulaiteye discusses early findings from the EMBLEM study, which aims to analyse the connection between Burkitt lymphoma, the first cancer to be found to have a virus associated with it, and malaria. (ecancer.org)
  • High-grade B-cell lymphoma that contains genetic changes that indicate the patient has a high risk of continued cancer growth. (mskcc.org)
  • Burkitt lymphoma (BL) is a very fast-growing type of cancer . (nih.gov)
  • There are 3 subtypes of Burkitt lymphoma. (cancer.ca)
  • b, Frequencies of CCND3 mutations in different lymphoma subtypes. (nih.gov)
  • DCEG's portfolio includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its subtypes. (cancer.gov)
  • An international consortial project to comprehensively evaluate the etiology of 11 non-Hodgkin lymphoma (NHL) subtypes, considering family and medical history, lifestyle and occupational risk factors, and inherited genetic susceptibility. (cancer.gov)
  • These differences between endemic and sporadic BL do not mean that each of these subtypes of lymphoma represents a perfectly homogeneous entity. (bmj.com)
  • citation needed] There are several subtypes of aggressive lymphoma. (wikipedia.org)
  • The high mitotic activity of Burkitt lymphoma is confirmed by nearly 100% of the cells staining positive for Ki67. (wikipedia.org)
  • As a result, blast cells don't mature properly, and these abnormal immature blood cells (called Burkitt lymphoma cells) are found in the circulating blood. (cancer.ca)
  • If more than 25% of the cells in the bone marrow are Burkitt lymphoma cells, doctors may classify it as acute lymphocytic leukemia (ALL), L3 or Burkitt-type leukemia. (cancer.ca)
  • When viewed under a microscope, Burkitt-like lymphoma cells look somewhat different from Burkitt lymphoma cells. (cancer.ca)
  • Tumour lysis syndrome (TLS) is a group of side effects that develops when a large number of lymphoma cells are killed in a short period of time. (cancer.ca)
  • CNS prophylaxis is used to try to prevent the lymphoma cells from entering the tissue covering the brain and spinal cord. (cancer.ca)
  • This finding identified MCL-1 as a therapeutic target for these particular lymphoma cells," said Dr Kelly. (leukaemia.org.au)
  • Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines. (sciencemag.org)
  • Immunohistochemical staining showed neoplastic cells consistent with Burkitt lymphoma. (appliedradiology.com)
  • In Burkitt lymphoma, nearly 100% of the cells stain positive for Ki-67. (renalandurologynews.com)
  • The nature of the unknown, unidentified virus in the cultured lymphoblasts from Burkitt's lymphomas is considered and its possible relationship to the cells discussed. (nih.gov)
  • When the bone marrow contains more than 25% malignant Burkitt cells, the definition of Burkitt leukemia is met, which can occur with or without lymphomatous involvement. (clinicaladvisor.com)
  • Imipramine-blue reduces the size of experimental Burkitt lymphoma significantly but does not affect the dissemination of BL2B95 cells, angiogenesis, and lymphangiogenesis. (aacrjournals.org)
  • Thereby, we concentrated on the non-Hodgkin lymphoma subtype Burkitt lymphoma, which arises from B cells. (aacrjournals.org)
  • 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
  • While this smear is more cellular than is ideal for optimum evaluation of morphology, it is still possible to recognize the characteristic morphology of the lymphoma cells present. (labce.com)
  • The Burkitt cells are as large or larger than the few neutrophils present and somewhat resemble other types of lymphoblasts. (labce.com)
  • Lymphoma cells may build up in the lymph nodes and other organs, causing swelling. (nih.gov)
  • We initiated studies in Burkitt lymphoma cells, which constitutively express c-MYC due to a chromosomal translocation, to determine whether Hedgehog or c-MYC regulates GLI1 expression. (luriechildrens.org)
  • The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt lymphoma cells. (luriechildrens.org)
  • Burkitt lymphoma cells do not seem to be Hedgehog responsive. (luriechildrens.org)
  • Adult non-Hodgkin lymphoma treatment (PDQ) - health professional version. (medlineplus.gov)
  • In children, most SNCLs are Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas. (lymphomation.org)
  • Adult Burkitt leukemia and lymphoma. (springer.com)
  • About one-half of all Burkitt lymphoma (BL) patients are younger than 40 years, and one-third belong to the adolescent and young adult (AYA) subset, defined by an age between 15 and 25-40 years, based on selection criteria used in different reports. (dovepress.com)
  • Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. (haematologica.org)
  • Outcomes for adult Burkitt lymphoma in a contemporary, large real-world analysis appear inferior to those of smaller published series. (mdedge.com)
  • Burkitt lymphoma is an aggressive B cell malignancy accounting for 1-2% of all adult lymphomas. (eur.nl)
  • Immunodeficiency-associated Burkitt lymphoma is usually associated with HIV infection [5] or occurs in the setting of post-transplant patients who are taking immunosuppressive drugs. (wikipedia.org)
  • Sporadic Burkitt lymphoma often involves the abdomen, and it spreads to the bone marrow in about 20% of patients. (lymphomation.org)
  • Immunodeficient Burkitt lymphoma affects patients with abnormal immune systems (e.g., patients with HIV). (lymphomation.org)
  • Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol. (lymphomation.org)
  • Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients. (cancer.gov)
  • Common findings and symptoms in patients with Burkitt lymphoma are summarized below. (medscape.com)
  • Patients with more than 25% bone marrow involvement are usually referred to as having Burkitt leukemia. (medscape.com)
  • The third form of Burkitt lymphoma occurs in patients who are immunocompromised. (appliedradiology.com)
  • While BL often responds well to treatment, for 15-20% of BL patients, chemotherapy either doesn't work well, they can't tolerate the aggressive treatment or the lymphoma relapses quickly after treatment. (leukaemia.org.au)
  • The purpose of this study is to learn more about how well a chemotherapy regime including rituximab works in treating patients with Burkitt or atypical Burkitt lymphoma. (clinicaltrials.gov)
  • Trends in survival of patients with Burkitt lymphoma/leukemia in the USA: an analysis of 3691 cases. (springer.com)
  • A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial). (springer.com)
  • Thus, there is the need to develop minimally toxic substances to treat patients with high-grade-non-Hodgkin lymphoma efficiently. (aacrjournals.org)
  • Patients must have Burkitt lymphoma/leukemia or high-grade B-cell lymphoma that has continued to grow or came back despite prior treatment. (mskcc.org)
  • Burkitt lymphoma (BL) is highly FDG-avid even though its usefulness in the management of these patients is still controversial. (ovid.com)
  • And the second point is that even though you succeed in treating properly elderly patients, the fraction of long survivors is lower and this is probably due to a different biology of disease when this type of lymphoma arises in a patient who is older than 65. (ecancer.org)
  • Determine the overall response rate (complete remission, complete remission undetermined, and partial remission) in HIV-negative or HIV-positive patients with newly diagnosed Burkitt's or Burkitt-like lymphoma treated with doxorubicin hydrochloride liposome and rituximab as part of the Magrath regimen. (knowcancer.com)
  • citation needed] AIDS-associated lymphoma Angioimmunoblastic lymphoma Central nervous system (CNS) lymphoma Mantle cell lymphoma (MCL) Some of the risk factors that increase the risk factor of aggressive lymphoma include: Immunosuppressive medication used for organ transplant patients or autoimmune diseases. (wikipedia.org)
  • While advanced high grade aggressive lymphoma patients receive similar treatments, the duration is extended. (wikipedia.org)
  • Sporadic Burkitt lymphoma (sBL) most often presents as abdominal tumors with bone marrow involvement. (medscape.com)
  • 2 The vascular encasement in Burkitt lymphoma differs from encasement seen in other tumors such as neuroblastoma. (appliedradiology.com)
  • Burkitt lymphoma-one of the most aggressive tumors-may be treatable with agents that can stop cell proliferation and induce cell death by reactivating two key proteins. (oncologynurseadvisor.com)
  • Since the presentation of aggressive lymphoma are similar to that of other types of Non-Hodgkin lymphoma it is important analyze the tumors morphologically and run immunohistochemical tests to ensure correct diagnosis. (wikipedia.org)
  • The lymphoma is in the central nervous system (brain or spinal cord) and/or the bone marrow when it is first found. (cancer.org)
  • Burkitt lymphoma can affect the bone marrow so that it doesn't work normally. (cancer.ca)
  • Immunodeficiency-related Burkitt lymphoma cases usually as with nodal involvement with frequent bone marrow involvement. (medscape.com)
  • Bone marrow involvement is documented in roughly 20% of cases of sporadic Burkitt lymphoma and may be much less common in the endemic variant. (renalandurologynews.com)
  • If Burkitt leukemia is suspected, perform a bone marrow biopsy and place cores in transport medium. (clinicaladvisor.com)
  • To evaluate the response rates in adults with Burkitt/atypical Burkitt. (clinicaltrials.gov)
  • Of the trial that contains atypical Burkitt/Burkitt-like lymphoma as an inclusion criterion, 1 is phase 2 (1 open). (mycancergenome.org)
  • Of the trial that contains NRIP3 status and atypical Burkitt/Burkitt-like lymphoma as inclusion criteria, 1 is phase 2 (1 open) [ 3 ]. (mycancergenome.org)
  • The treatment and prognosis (outlook) for a child with non-Hodgkin lymphoma (NHL) depend, to a large extent, on the lymphoma's stage. (cancer.org)
  • Chemotherapy is the main treatment for Burkitt lymphoma. (cancer.ca)
  • A goal of initiating therapy within 48 hours of presentation has been proposed as optimal treatment for Burkitt lymphoma. (renalandurologynews.com)
  • Thanks to your generous donations to this project, poor children from rural villages have access to the necessary treatment for Burkitt lymphoma, including salvage therapy when needed, in order to provide them with the hope for long-lasting cure and the chance to fulfill their dreams. (globalgiving.org)
  • In this observational study, we compared real-world efficacy, toxicity, and costs of four frequently employed treatment strategies for Burkitt lymphoma: the Lymphome Malins B (LMB), the Berlin-Frankfurt-Münster (BFM), the HOVON, and the CODOX-M/IVAC regimens. (eur.nl)
  • We conclude that the four treatment protocols for Burkitt lymphoma yield nearly identical results with regards to efficacy and safety but differ in treatment duration and costs. (eur.nl)
  • For aggressive lymphoma, swift and specific treatment dependent upon correct diagnosis can be the difference between life and death for the patient. (wikipedia.org)
  • citation needed] For limited high grade lymphoma the typical treatment is chemotherapy and a targeted drug, followed by radiotherapy. (wikipedia.org)
  • Burkitt lymphoma is a type of mature B-cell non-Hodgkin lymphoma (NHL). (cancer.ca)
  • Burkitt lymphoma is commonly associated with the infection of B cell lymphocytes with the Epstein-Barr virus (EBV) and in these cases in considered to be one form of the Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
  • B-cell lymphomas arise at distinct stages of cellular development and maturation, potentially influencing antigen (Ag) presentation and T-cell recognition. (hindawi.com)
  • From OncologyChannel: 'Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. (lymphomation.org)
  • FACS analysis of lymphoma cell lines transduced with mutant or wild type GFP-CCND3 fusion proteins. (nih.gov)
  • Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. (alexslemonade.org)
  • An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. (cancer.gov)
  • Biopsy findings were consistent with small noncleaved cell non-Hodgkin lymphoma. (medscape.com)
  • A lot of our work has been in cell lines established from these Burkitt's lymphomas. (leukaemia.org.au)
  • The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. (sciencemag.org)
  • At histology, Burkitt lymphoma has a classic "starry sky" appearance due to rapid cell proliferation and spontaneous cell death. (appliedradiology.com)
  • The Epstein-Barr virus genome carried in the Burkitt lymphoma nonproducer cell line Raji was characterized by partial denaturation mapping and by hybridization of cloned viral fragments to filters containing separated Raji DNA fragments. (nih.gov)
  • Burkitt Lymphoma (BL) is a fast growing malignancy of B cell origin typically associated with a rapid onset and progression of symptoms. (clinicaladvisor.com)
  • CNS involvement in small noncleaved-cell lymphoma: is CNS disease per se a poor prognostic sign? (springer.com)
  • Outcome of and prognostic factors for relapse in children and adolescents with mature B-cell lymphoma and leukemia treated in three consecutive prospective "Lymphomes Malins B" protocols. (springer.com)
  • Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen. (springer.com)
  • Burkitt Lymphoma is one of the rare types of B-cell non-Hodgkin's lymphoma. (marketresearch.com)
  • The aim of this study is to investigate the potential of Hypoxanthine phosphoribosyltransferase (HPRT) as a surface biomarker and target for future immunotherapies in Burkitt's B-cell Lymphoma. (aacrjournals.org)
  • HPRT presence on the surface of this B-cell lymphoma subtype could provide a target for adoptive cell transfer and other immunotherapies. (aacrjournals.org)
  • Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
  • Since in Burkitt lymphoma these two proteins [INK4a and ARF] are not inactivated at the genetic level, their inactivation could be pharmacologically reversible," explained lead author Annalisa Roberti in a statement describing her group's findings, which were reported in the journal Cell Cycle (2011;10[1]:127-134). (oncologynurseadvisor.com)
  • It is a form of B- cell non-Hodgkin's lymphoma . (nih.gov)
  • We show that all Burkitt lymphoma cell lines tested express GLI1, PTCH1, and SMO and that five of six Burkitt lymphomas express GLI1. (luriechildrens.org)
  • The Raji, EB1, and EB2 cell lines are derived from Epstein-Barr virus (EBV)-positive Burkitt's lymphomas. (asm.org)
  • 2016) An Innovative Cisplatin Diammine II Benzene-Poly- Carboxylic Acid Complex Inhibits Growth of Burkitt`S Cell Lymphoma In Vitro and In Vivo. (omicsonline.org)
  • Peripheral T-cell lymphomas are less common accounting for approximately 7% of all non-Hodgkin lymphoma cases. (wikipedia.org)
  • In 1958, Dennis Burkitt first described a disorder associated with jaw tumours in African children. (bmj.com)
  • An aggressive Burkitt lymphoma which affects adults and arises in a follicular lymphoma. (thefreedictionary.com)
  • Aggressive lymphoma, also known as high-grade lymphoma, is a group of fast growing Non-Hodgkin Lymphoma. (wikipedia.org)
  • Sporadic lymphomas are rarely associated with the Epstein-Barr virus. (wikipedia.org)
  • FISH analysis was indicative of a MYC oncogene rearrangement, commonly associated with Burkitt lymphoma. (appliedradiology.com)
  • Burkitt lymphoma commonly involves extranodal sites, usually when bulky disease is present. (appliedradiology.com)
  • In western countries where sporadic Burkitt lymphoma occurs more commonly, this presentation is relatively rare. (renalandurologynews.com)
  • So it was welcome news that an international team of scientists has unveiled some of the cancer's genetic secrets, making this form of non-Hodgkin's lymphoma easier to treat. (nih.gov)
  • Such a possibility has been spawned by a recent discovery regarding a genetic locus that has an important role in Burkitt lymphoma. (oncologynurseadvisor.com)
  • The differential diagnosis is vast, as lymphoma can affect almost any organ. (scielo.org.za)
  • If Burkitt lymphoma is suspected, all or part of an enlarged lymph node or other suspicious disease site will be biopsied. (webmd.com)
  • Stage I and II lymphomas are usually considered limited-stage disease and are treated the same way. (cancer.org)
  • Stage III and IV lymphomas are usually thought of as advanced-stage disease and are also treated alike. (cancer.org)
  • The fact that some Burkitt lymphoma cases do not involve EBV allows that many cases of the disease are not caused and/or promoted by EBV, i.e. the virus may be an innocent passenger virus in these cases. (wikipedia.org)
  • Multimodality imaging of Hodgkin disease and non-Hodgkin lymphoma in children. (scielo.org.za)
  • At present, though it is a highly malignant disease with demonstrated propensity to rapid growth and dissemination, provided it is correctly identified and treated, BL is the aggressive lymphoma subset associated with the highest cure rate in both adults and children. (dovepress.com)
  • Pediatric Hodgkin and non-Hodgkin lymphomas. (cancer.org)
  • As such, Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults. (renalandurologynews.com)
  • Pediatric Burkitt lymphoma has historically been treated with intensive methotrexate-based chemotherapy, which improves patient survival while causing severe toxicities. (ovid.com)
  • Immunodeficiency-associated Burkitt lymphoma may demonstrate more plasmacytic appearance or more pleomorphism, but these features are not specific. (wikipedia.org)
  • Immunodeficiency-associated Burkitt lymphoma tends to occur in people with weakened immune systems, typically those with HIV infection. (cancer.ca)
  • The number of cases of immunodeficiency-associated Burkitt lymphoma seems to be dropping because antiretroviral therapy is used to treat HIV. (cancer.ca)
  • There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). (cancer.gov)