Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Lymphoma, T-Cell
Herpesvirus 4, Human
Lymphoma, Follicular
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Lymphoma, AIDS-Related
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Translocation, Genetic
Chromosomes, Human, 6-12 and X
Lymphoma, B-Cell, Marginal Zone
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.
Epstein-Barr Virus Nuclear Antigens
Chromosomes, Human, 13-15
Glutamate Formimidoyltransferase
Genes, myc
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
Proto-Oncogene Proteins c-myc
B-Lymphocytes
Epstein-Barr Virus Infections
Lymphoma, Mantle-Cell
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Lymphoma, T-Cell, Cutaneous
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Lymphoma, T-Cell, Peripheral
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
Lymphoma, Large-Cell, Anaplastic
Chromosomes, Human, Pair 14
Tumor Cells, Cultured
Germinal Center
Oncogenes
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Antibodies, Monoclonal, Murine-Derived
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
In Situ Hybridization, Fluorescence
Antigens, CD20
Chromosomes, Human, 1-3
Genes, Immunoglobulin Heavy Chain
Immunophenotyping
Immunoglobulin Heavy Chains
Sesquiterpenes, Guaiane
Doxorubicin
Gene Rearrangement
Sesquiterpenes, Eudesmane
Chromosomes, Human, Pair 8
Neprilysin
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Cytogenetics
Antineoplastic Combined Chemotherapy Protocols
Lymphoma, Large-Cell, Immunoblastic
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
Viral Matrix Proteins
HLA-A11 Antigen
Genes, myb
Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Genes, bcl-2
Plasmacytoma
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Base Sequence
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tanacetum parthenium
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Virus Latency
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
Prednisone
Inhibitor of Differentiation Proteins
Lymphoproliferative Disorders
Genes, Immunoglobulin
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
Chromosome Banding
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Treatment Outcome
Methotrexate
Receptors, Antigen, B-Cell
Cell Transformation, Viral
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proto-Oncogenes
Leukemia, Lymphoid
Prognosis
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Remission Induction
Lymphoma, Extranodal NK-T-Cell
Cell Transformation, Neoplastic
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Transcription, Genetic
Cell Line, Transformed
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Gene Expression Regulation, Viral
Chaperonin Containing TCP-1
Biopsy
Hybrid Cells
Virus Activation
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)
Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL) cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other EBV-positive BL cells express a restricted set of EBV gene products (type I latency) that are not known to overtly affect cell growth. Here we demonstrate that reestablishment of type I latency in EBV-negative Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resistance to apoptosis under growth-limiting conditions. The antiapoptotic effect of EBV was associated with a higher level of Bcl-2 expression and an EBV-dependent decrease in steady-state levels of c-MYC protein. Although the EBV EBNA-1 protein is expressed in all EBV-associated tumors and is reported to have oncogenic potential, enforced expression of EBNA-1 alone in EBV-negative Akata cells failed to restore tumorigenicity or EBV-dependent down-regulation of c-MYC. These data provide direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a novel model whereby a restricted latency program of EBV promotes B-cell survival, and thus virus persistence within an immune host, by selectively targeting the expression of c-MYC. (+info)Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)
CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels. (+info)Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)
Bruton's tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B cells is still unclear. This study represents a search for the substrate for Btk in vivo. We identified one of the major phosphoproteins associated with Btk in the preB cell line NALM6 as the Wiskott-Aldrich syndrome protein (WASP), the gene product responsible for Wiskott-Aldrich syndrome, which is another hereditary immunodeficiency with distinct abnormalities in hematopoietic cells. We demonstrated that WASP was transiently tyrosine-phosphorylated after B-cell antigen receptor cross-linking on B cells, suggesting that WASP is located downstream of cytoplasmic tyrosine kinases. An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk. A protein binding assay suggested that the tyrosine-phosphorylation of WASP alters the association between WASP and a cellular protein. Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown. (+info)Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)
In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-crossblocking pairs), polyclonal anti-mu Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fab', F(ab')2 and F(ab')3 derivatives from anti-Fc mu mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (C mu2-C mu4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-Fd mu, or C mu1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb. (+info)Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)
Ligation of CD40 on the surface of B cells induces multiple phenotypic effects, many of which are mimicked by the EBV latent membrane protein 1 (LMP1) through its interaction with downstream components of the CD40 signaling pathway. Because the effects of LMP1 have been most closely studied in human Burkitt Lymphoma (BL) cell lines retaining a tumor biopsy-like phenotype in vitro, we have examined the response of a panel of such lines to CD40 ligation. Two distinct patterns of response were observed that were unrelated to the surface level of CD40 or to the EBV genome status of the lines. Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition. Aggregation was seen at lower doses than those required to elicit the other effects. By contrast, low responder (LR) lines showed no detectable response to CD40 mAbs, while their responses to sCD40L were limited to activation of NF-kappa B and up-regulation of CD95 only. However, in transfection experiments, LMP1 uniformly induced the full spectrum of phenotypic effects in both HR and LR lines. We conclude that some BL cell lines show a highly restricted response to CD40 ligation but remain fully susceptible to LMP1. (+info)Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)
Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans. (+info)Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)
The consistent presence of EBV genomes in certain tumor types (in particular, AIDS-related central nervous system lymphomas and nasopharyngeal carcinomas) may allow novel, EBV-based targeting strategies. Tumors contain the latent (transforming) form of EBV infection. However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce lytic EBV infection, resulting in death of the host cell. We have constructed replication-deficient adenovirus vectors expressing the BZLF1 or BRLF1 immediate-early genes and examined their utility for killing latently infected lymphoma cells in vitro and in vivo. We show that both the BZLF1 and BRLF1 vectors efficiently induce lytic EBV infection in Jijoye cells (an EBV-positive Burkitt lymphoma cell line). Furthermore, lytic EBV infection converts the antiviral drug, ganciclovir (GCV), into a toxic (phosphorylated) form, which inhibits cellular as well as viral DNA polymerase. When Jijoye cells are infected with the BZLF1 or BRLF1 adenovirus vectors in the presence of GCV, viral reactivation is induced, but virus replication is inhibited (thus preventing the release of infectious EBV particles); yet cells are still efficiently killed. Finally, we demonstrate that the BZLF1 and BRLF1 adenovirus vectors induce lytic EBV infection when they are directly inoculated into Jijoye cell tumors grown in severe combined immunodeficiency mice. These results suggest that induction of lytic EBV infection in tumors, in combination with GCV, may be an effective strategy for treating EBV-associated malignancies. (+info)Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)
In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene becomes transcriptionally activated as a consequence of the chromosomal translocation and shows preferential usage of promoter P1 over P2, a phenomenon referred to as promoter shift. In order to define the responsible regulatory elements within the Ig lambda locus, we studied the effect of the human Ig lambda enhancer (HuE lambda) on c-myc expression after stable transfection into BL cells. A 12 kb genomic fragment encompassing HuE lambda, but not HuE lambda alone, strongly activated c-myc expression and induced the promoter shift. To identify additional elements involved in c-myc deregulation, we mapped DNaseI hypersensitive sites within the 12 kb lambda fragment on the construct. Besides one hypersensitive site corresponding to HuE lambda, three additional sites were detected. Two of these elements displayed enhancer activity after transient transfection. The third element did not activate c-myc transcription, but was required for full c-myc activation and promoter shift. Deletion analyses of the c-myc promoter identified the immediate promoter region as sufficient for activation by the Ig lambda. locus, but also revealed that induction of the promoter shift requires additional upstream elements. (+info)
Burkitt Lymphoma Archives | Morgan Adams Foundation
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Burkitt lymphoma
... of lymphoma cases can be attributed to Burkitt lymphoma. The peak incidence for endemic Burkitt lymphoma is from ages 4 to 7 ... Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis. Burkitt lymphoma can be divided into three main ... EBV infection is associated with Burkitt lymphoma. EBV is found in virtually all instances of endemic Burkitt lymphoma. The ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ...
Denis Parsons Burkitt
Books Burkitt, D. P.; Wright, D. H. (1970). Burkitt's Lymphoma. Livingstone. ISBN 0443007004. LCCN 72021505. Burkitt, D. P.; ... Denis P. Burkitt, "Discovering Burkitt's Lymphoma" in Paul H. Levine, Epstein-Barr Virus and Human Disease (Humana Press 1987) ... Burkitt, together with Dr. Dennis Wright, published a book titled Burkitt's Lymphoma in April 1970. His second major ... Biography Dennis Wright Archived 26 June 2009 at the Wayback Machine Burkitt, D. P; Wright, Dennis H (1970). Burkitt's lymphoma ...
Aggressive lymphoma
These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, ... Burkitt lymphoma is named after the British surgeon Denis Burkitt. Burkitt identified this disease in 1956 in children in ... AIDS-associated lymphoma Angioimmunoblastic lymphoma Central nervous system (CNS) lymphoma Mantle cell lymphoma (MCL) Some of ... diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. Diffuse large B-cell lymphoma ...
Dennis H. Wright
Denis Burkitt in describing the pathology of Burkitt lymphoma. Wright became a leading expert on lymphomas. In 1964 he ... Burkitt, Denis P.; Wright, Dennis H. (1970). Burkitt's Lymphoma. Edinburgh: Livingstone. ISBN 0443007004. LCCN 72021505; xi+251 ... He received in 1973 the Paul Ehrlich and Ludwig Darmstaedter Prize for his research on the pathology of Burkitt lymphoma. He ... he and his coworkers were among the first to describe T-cell lymphomas associated with enteropathy and to describe lymphomas of ...
Epstein-Barr virus infection
... causing excessive proliferation observed as Burkitt's lymphoma. Burkitt's lymphoma commonly affects the jaw bone, forming a ... Burkitt's lymphoma is a type of Non-Hodgkin's lymphoma and is most common in equatorial Africa and is co-existent with the ... Nasopharyngeal cancer Several Non-Hodgkin's lymphomas, including Burkitt's lymphoma and primary cerebral lymphoma Post- ... Burkitt's lymphoma, and Epstein-Barr virus positive diffuse large B-cell lymphoma, not otherwise specified); 2) non-lymphoid ...
List of OMIM disorder codes
MAOA Burkitt's lymphoma; 113970; MYC Buschke-Ollendorff syndrome; 166700; LEMD3 C syndrome; 211750; CD96 C5 deficiency; 609536 ... FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin's lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; ...
Bozoma Saint John
"Peter Saint John". Burkitt's Lymphoma Society. 2013. Archived from the original on June 9, 2017. Retrieved June 9, 2017. "In ...
Alexander John Haddow
Burkitt, D. P. (1971). "Epidemiology of Burkitt's Lymphoma". Proceedings of the Royal Society of Medicine. 64 (9): 909-910. doi ... Other notable work included relating the incidence of Burkitt's lymphoma to climatic conditions and the discovery of several ... Haddow's most prominent work was considered to be that on yellow fever and Burkitt's lymphoma. The Zika virus has since emerged ...
Azzopardi phenomenon
Peng SL, Cheng CN, Chang KC (2007). "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682-3. doi: ...
Epstein-Barr virus-associated lymphoproliferative diseases
Burkitt lymphoma (BL); Hodgkin lymphoma (HL); plasmablastic lymphoma (PBL); and primary effusion lymphoma (PEL) (also termed ... Burkitt lymphoma occurs in three forms. Epidemic Burkitt lymphoma (eBL) is common in Africa, the Middle East, Brazil, Papua New ... Two extremely rare types of the intravascular lymphomas, intravascular NK-cell lymphoma and intravascular T- cell lymphoma, are ... angioimmunoblastic T-cell lymphoma (AITL), and anaplastic lymphoma kinase positive or negative anaplastic large-cell lymphoma ( ...
LL-100 panel
PULVERTAFT, JV (1 February 1964). "Cytology of Burkitt's Tumour (African Lymphoma)". Lancet. 1 (7327): 238-40. doi:10.1016/ ... established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma". Leukemia & Lymphoma. 43 (11): 2179- ... "Characteristics of new cell lines derived from Burkitt lymphomas". Cancer. 23 (1): 64-79. doi:10.1002/1097-0142(196901)23:1. ... "An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and ...
1958 in science
Denis Parsons Burkitt first describes Burkitt's lymphoma. February 7 - Discovery of "Deep Skull" in Niah Caves in Sarawak by ... synd/2511 at Who Named It? Burkitt, D. (1958). "A sarcoma involving the jaws in African children". The British Journal of ...
Epstein-Barr virus stable intronic-sequence RNAs
Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma). Non-coding RNAs (ncRNAs) have a role in this process. ... of endemic Burkitt's lymphoma. Splicing of these W repeat transcripts produces a short intron and a long intron (Fig. 1), both ... "An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt ...
Deaths in June 2009
Anthony Yeo, 60, Singaporean counsellor, Burkitt's lymphoma. Gilda Galán, 92, Puerto Rican actress. Lorena Gale, 51, Canadian ... Alan Berkman, 63, American physician and activist, lymphoma. Fleur Cowles, 101, American writer, editor and artist. Baciro Dabó ... Luo Jing, 48, Chinese news presenter, lymphoma. Adilgerei Magomedtagirov, 53, Russian general, Interior Minister for the ... Fred Travalena, 66, American comedian and impressionist, non-Hodgkin lymphoma. Lucia Lauria Vigna, 113, Italian ...
List of breast cancer patients by survival status
Treated for breast cancer and Burkitt's lymphoma; pending remission from both cancers. Dorothy Hamill (born 1956), American ...
Lymphoma
Burkitt lymphoma; large B cell lymphoma, not otherwise specified; diffuse large B cell lymphoma associated with chronic ... Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma ... Hodgkin lymphoma Classical Hodgkin lymphomas: Nodular sclerosis form of Hodgkin lymphoma Most common type of Hodgkin lymphoma ... large B-cell lymphoma ALK+ large B-cell lymphoma Plasmablastic lymphoma Primary effusion lymphoma Large B-cell lymphoma arising ...
Bert Achong
Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt lymphoma samples by ... Epstein, M.A; Achong, B.G; Barr, Y.M (1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". The Lancet. ... Epstein, Anthony (2012-03-01). "Burkitt lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology. 156 ... "Morphological and Biological Studies on a Virus in Cultured Lymphoblasts from Burkitt's Lymphoma". Journal of Experimental ...
History of cancer
Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...
Namrata Singh Gujral
... she was treated for Burkitt's lymphoma. She was treated with aggressive chemotherapy including intrathecal chemotherapy at City ... The cause of lymphoma was prior chemotherapy from 2008 for breast cancer. In 2013, Gujral was in remission from both cancers. ... Lisa Tsering (2013-08-06). "Actress fights lymphoma Urges Community Awareness". India West. Archived from the original on 2013- ...
1964 in science
Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964-03-28). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma". ...
QSER1
Overexpression of QSER1 was noted in Burkitt's Lymphoma. QSER1 expression also increases with increasing Gleason score (more ... Altered expression of QSER1 is noted in pathological cardiomyopathy, Burkitt's Lymphoma, prostate cancer, and some breast ...
Deaths in January 1998
Nick Venet, 61, American record producer, Burkitt's lymphoma. Wayne Ambler, 82, American baseball player. Essie Coffey, 56, ... Sally Purcell, 53, British poet and translator, lymphoma of brain cells. Mae Questel, 89, American actress (Betty Boop), ... Junior Wells, 63, American blues vocalist and harmonica player, lymphoma. Gayane C'ebotaryan, 79, Armenian composer and ...
Oncovirus
In 1964 Anthony Epstein, Bert Achong and Yvonne Barr identified the first human oncovirus from Burkitt's lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... Infectious causes of cancer Carcinogen Oncogenic Oncogene Adult T-cell leukemia/lymphoma Cancer bacteria Oncolytic virus, a ... B-cell non-Hodgkin's lymphoma, and cancer". World Journal of Hepatology. 7 (3): 327-343. doi:10.4254/wjh.v7.i3.327. PMC 4381161 ...
Primary central nervous system lymphoma
Other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS lymphoma is highly associated with Epstein-Barr ... Primary central nervous system lymphoma (PCNSL), also termed primary diffuse large B-cell lymphoma of the central nervous ... Primary CNS Lymphoma~treatment at eMedicine Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, et al. ( ... Primary CNS Lymphoma at eMedicine Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA (March 2013). "A systematic ...
Epstein-Barr virus
... including Burkitt's lymphoma, hemophagocytic lymphohistiocytosis, Hodgkin's lymphoma, stomach cancer, nasopharyngeal carcinoma ... 2014). "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... and hydroa vacciniforme as well as malignant lymphoproliferative diseases such as Epstein-Barr virus-positive Burkitt lymphoma ...
Idiopathic CD4+ lymphocytopenia
... primary leptomeningeal lymphoma, diffuse large cell lymphoma,[non-primary source needed] MALT lymphoma, and Burkitt's lymphoma ... Shimano S, Murata N, Tsuchiya J (July 1997). "[Idiopathic CD4+ T-lymphocytopenia terminating in Burkitt's lymphoma]". Rinsho ... Campbell JK, Prince HM, Juneja SK, Seymour JF, Slavin M (April 2001). "Diffuse large cell lymphoma and t(8;22) (q24;q11) in a ... Lymphoma. 41 (3-4): 421-3. doi:10.3109/10428190109057998. PMID 11378556. S2CID 23366810. Longo F, Hébuterne X, Michiels JF, ...
History of virology
He was the first to describe a type of cancer that now bears his name Burkitt's lymphoma. This type of cancer was endemic in ... ISBN 978-1-904455-03-5. Bornkamm GW (April 2009). "Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more ... Magrath I (September 2009). "Lessons from clinical trials in African Burkitt lymphoma". Current Opinion in Oncology. 21 (5): ... In an attempt to find a cause for the cancer, Burkitt sent cells from the tumour to Anthony Epstein (b. 1921) a British ...
Nick Venet
He died on 2 January 1998 of Burkitt's lymphoma. Just over one month before Beach Boy Carl Wilson. He was survived by his wife ... Deaths from non-Hodgkin lymphoma, 20th-century American businesspeople, Deaths from cancer in California). ...
Sid Couchey
In February 2012, Couchey was diagnosed with Burkitt's lymphoma. The aggressive cancer took hold quickly, and Couchey died on ...
Myc
The most frequently discussed example of c-Myc as a proto-oncogene is its implication in Burkitt's lymphoma. In Burkitt's ... A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...
Cervical cancer
Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, ... Noncarcinoma malignancies which can rarely occur in the cervix include melanoma and lymphoma. The International Federation of ...
Galectin-9
"A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells". British ... Hodgkin and Non-Hodgkin lymphomas, AML or solid tumors, such as lung cancer, breast cancer, and hepatocellular carcinoma. ...
Find-me signals
CX3CL1 could also be released as part of microparticles from the beginning stages of apoptotic death of Burkitt Lymphoma cells ... is mediated through the release of a 60 kDa microparticle fragment of fractalkine from the beginning stages of Burkitt Lymphoma ...
Joseph H. Burchenal
... a winner of the 1972 Albert Lasker Award for Medical Research for his work on developing a chemotherapy for Burkitt's lymphoma ...
Oncogene
The MYC gene is implicated in Burkitt's lymphoma, which starts when a chromosomal translocation moves an enhancer sequence ...
Neprilysin
Follicular lymphoma (follicle centre cell lymphoma) are CD10+. Burkitt Lymphoma cells are CD10+. CD10+ diffuse large B cell ... and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells ... Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic ... "Differentiating between Burkitt lymphoma and CD10+ diffuse large B-cell lymphoma: the role of commonly used flow cytometry cell ...
George Archer
Archer died of Burkitt's lymphoma - a lymphatic system malignancy - in Incline Village, Nevada in 2005, several days before his ... Deaths from lymphoma, Deaths from cancer in Nevada, 1939 births, 2005 deaths). ...
AIDS-defining clinical condition
Kaposi's sarcoma Lymphoma, Burkitt's Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of brain Mycobacterium ... non-Hodgkin's lymphoma, lymphocytic leukemia, multiple myeloma, or any cancer of lymphoreticular or histiocytic tissue, or ...
Robert James Valentine Pulvertaft
... carried out studies on Burkitt lymphoma. At the age of 70 Pulvertaft returned to England, settling in Dorset, and later moving ... After his retirement from Westminster, he travelled to Africa, where he conducted research on lymphoma. Pulvertaft returned to ...
White blood cell
Daniels VG, Wheater PR, Burkitt HG (1979). Functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone. ... cancers of white blood cells can be broadly classified as leukemias and lymphomas, although those categories overlap and are ...
Oncolytic virus
Burkitt lymphoma, and Hodgkin lymphoma, after immunisation or infection with an unrelated virus appeared at the beginning of ...
Acute lymphoblastic leukemia
Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... Burkitt leukemia) at presentation. The signs and symptoms of ALL are variable and include: Generalized weakness and feeling ... The WHO subtypes related to ALL are: B-lymphoblastic leukemia/lymphoma Not otherwise specified (NOS) with recurrent genetic ... August 2005). "Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas". ...
Tumors of the hematopoietic and lymphoid tissues
... disorder Burkitt lymphoma Burkitt-like lymphoma with 11q aberration High-grade B-cell lymphoma High-grade B-cell lymphoma with ... large B-cell lymphoma Intravascular large B-cell lymphoma ALK-positive large B-cell lymphoma Plasmablastic lymphoma Primary ... MALT lymphoma) Nodal marginal zone lymphoma Paediatric nodal marginal zone lymphoma Follicular lymphoma In situ follicular ... lymphoma Large B-cell lymphoma with IRF4 rearrangement Primary cutaneous follicle centre lymphoma Mantle cell lymphoma In situ ...
Mir-26 microRNA precursor family
Burkitt lymphoma miR-26a plays a role as a potential tumor-suppressor in MYC-induced lymphoma. miR-26a is found to be ... downregulated in primary human Burkitt lymphoma and MYC-driven lymphoma cell lines. Ectopic expression of miR-26a influences ...
Late life depression
April 2003). "Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells". ...
Triple-stranded DNA
... with it playing a role in the development of Burkitt lymphoma and leukemia. The triple-stranded DNA regions can be generated ... translocation observed in many cancers and most follicular lymphomas. This observation has led to research that indicated a ...
Diffuse large B-cell lymphoma associated with chronic inflammation
EBV+ Burkitt lymphoma, EBV+ Hodgkin lymphoma, and the EBV+ diffuse large B-cell lymphomas which include as a subtype, DLBCL-CI ... Articles with short description, Short description matches Wikidata, Lymphoma, Non-Hodgkin lymphoma, Lymphoid-related cutaneous ... Similar to DLBCL-CI, FA-DLBCL is a diffuse large B-cell lymphoma that arises in immunologically sequestered sites (e.g. body ... DLBCL-CI therefore appears to be a lymphoma that is driven by EBV-induced changes in the expression of various genes that ...
Ccdc109b
Changes in CCDC109B expression are also present in other diseases such as glioblastomas, Daudi Burkitt's lymphoma, Duchenne ... CCDC109B may contribute to a number of diseases including various lymphomas and leukemias. ...
Joe Andruzzi
On May 30, 2007, Andruzzi was diagnosed with non-Hodgkin's Burkitt's lymphoma, predicted to double in size in just 24 hours. ...
Uganda Cancer Institute
... to treat childhood lymphomas, predominantly Burkitt's lymphoma, the most common childhood lymphoma in Uganda and endemic to ... UCI was founded in 1967 with twenty beds, as the Lymphoma Treatment Center, ...
Julia Bodmer
Burkitt's lymphoma and testicular cancer. As a consequence of her work at the ICRF she was able to contribute to the ...
List of MeSH codes (C04)
... lymphoma, non-hodgkin MeSH C04.557.386.480.150 - B-cell lymphoma MeSH C04.557.386.480.150.165 - burkitt lymphoma MeSH C04.557. ... burkitt lymphoma MeSH C04.557.386.480.450 - lymphoma, intermediate-grade MeSH C04.557.386.480.450.300 - lymphoma, large-cell, ... lymphoma, small noncleaved-cell MeSH C04.557.386.480.875.775.165 - burkitt lymphoma MeSH C04.557.386.720 - plasmacytoma MeSH ... lymphoma, small-cell MeSH C04.557.386.480.300 - lymphoma, diffuse MeSH C04.557.386.480.300.300 - lymphoma, large-cell, diffuse ...
Merkel cell polyomavirus
Kaposi's sarcoma and Burkitt's lymphoma are examples of tumors known to have a viral etiology that occur at increased frequency ...
Toothache
Various conditions may involve the alveolar bone, and cause non-odontogenic toothache, such as Burkitt's lymphoma,: 340 ...
UWA-101
2010). "Redesigning the designer drug ecstasy: nonpsychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity". ... but had potent anti-cancer effects against Burkitt's lymphoma cells in vitro. UWA-121 is the (R)-enantiomer of UWA-101 and the ... August 2012). "Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative ...
Burkitt lymphoma: MedlinePlus Medical Encyclopedia
... is a very fast growing form of non-Hodgkin lymphoma. ... Burkitt lymphoma (BL) is a very fast growing form of non- ... B-cell lymphoma; High-grade B-cell lymphoma; Small noncleaved cell lymphoma ... Adult non-Hodgkin lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment- ...
Epidemiologic Notes and Reports
Burkitt's Lymphoma -- Winchester, Virginia
Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, Virginia Three cases of Burkitts lymphoma (BL) have occurred ... editorial note: Burkitts lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it ... Brubaker G, Geser A, Pike MC: Burkitts lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of ... Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of American Burkitts Lymphoma in neighbors. N Engl J Med 288: ...
Browsing by Subject "Burkitt Lymphoma"
Burkitt Lymphoma and Burkitt-like Lymphoma Differential Diagnoses
... or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by ... the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, ... encoded search term (Burkitt Lymphoma and Burkitt-like Lymphoma) and Burkitt Lymphoma and Burkitt-like Lymphoma What to Read ... Lymphoblastic lymphoma may be histologically similar to Burkitt lymphoma (BL), however, it is a T-cell lymphoma that expresses ...
Burkitt lymphoma, beyond discoveries
... Guest edited by: Dr Sam Mbulaiteye. Burkitt Lymphoma (BL) is an aggressive non-Hodgkin ... Burkitt Lymphoma: beyond discoveries First described in 1958 in Uganda, Burkitt lymphoma (BL) attracted interest worldwide ... Particularly, Burkitts lymphoma belongs to the family of B Non Hodgkin aggressive lymphomas. Although it is morph... ... Identification of a novel variant of LMP-1 of EBV in patients with endemic Burkitt lymphoma in western Kenya Epstein Barr virus ...
Browsing by Subject "Burkitt Lymphoma"
Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma...
Burkitts leukemia or Burkitts lymphoma or primary mediastinal large B-cell lymphoma. or B-precursor lymphoblastic lymphoma or ... Burkitts Lymphoma, Burkitts Leukemia, Mediastinal Neoplasms, Lymphoblastic Lymphoma, Large Cell Anaplastic Lymphoma ... Multicenter Study to Optimise Therapy of B-ALL, Burkitts NHL and High-Grade Non-Hodgkins Lymphoma in Adults (Amend 7). Trial ... Multicenter Study to Optimise Therapy of B-ALL, Burkitts NHL and High-Grade Non-Hodgkins Lymphoma in Adults (Amend 7) ...
Burkitt Lymphoma Market - Request Customization Form
Clinical significance of MYC expression and/or "High-grade" morphology in non-burkitt, diffuse aggressive B-cell lymphomas: A...
N2 - The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant ... AB - The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant ... The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant overlap ... abstract = "The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show ...
ICD-10-CM Code C83.78 - Burkitt lymphoma, lymph nodes of multiple sites
The ICD code C837 is used to code Burkitts lymphoma Burkitt lymphoma (Burkitts tumor, Burkitts lymphoma, or malignant ... Burkitt lymphoma, lymph nodes of multiple sites BILLABLE Billable Code Billable codes are sufficient justification for ... C83.78 is a billable ICD code used to specify a diagnosis of burkitt lymphoma, lymph nodes of multiple sites. A billable code ... DRG Group #840-842 - Lymphoma and non-acute leukemia with MCC. * DRG Group #840-842 - Lymphoma and non-acute leukemia with CC. ...
New prognostic index for Burkitt lymphoma - BJH
Burkitt lympohoma (BL) is a rare high-grade B-cell lymphoma, which in most cases is studied in small numbers. Definitions of ... New prognostic index for Burkitt lymphoma February 2021 Clinical practice Jeroen Beekwilder ... Burkitt Lymphoma International Prognostic Index. J Clin Oncol 2021; doi:10.1200/JCO.20.03288. ...
Non-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, Staging
What studies are recommended by the NCCN to establish a diagnosis of the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ... What are the NCCN recommendations for follow-up in patients with the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ... What are the variants of the Burkitt lymphoma (BL) form of non-Hodgkin lymphoma (NHL) identified by the 2008 WHO classification ... What are the age and race risk factors for the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ...
B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma) :: Peer Reviewed Pediatric Radiology Cases: :: The peer reviewed...
Sporadic Burkitt Lymphoma) Peer Reviewed Pediatric Radiology Cases ... B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma) B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). Dirk ... Sporadic Burkitt Lymphoma). Dirk Schaper, P G bel. B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). PedRad [serial ... Sporadic Burkitt Lymphoma). Dirk Schaper, P G bel. B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). PedRad [serial ...
IMSEAR at SEARO: Burkitt's lymphoma.
Burkitt's lymphoma
named after Denis Burkitt, 1911-93, British doctor, who first described it} ... Burkitts lymphoma - Bur·kitt s lymphoma .bər kəts also Burkitt lymphoma kət n a malignant lymphoma that affects primarily the ... Burkitts lymphoma - Infobox Disease Name = Burkitt s lymphoma Caption = Burkitt lymphoma, touch prep, Wright stain DiseasesDB ... Burkitts lymphoma - also Burkitt lymphoma noun Etymology: Denis Parsons Burkitt died 1993 British surgeon Date: 1963 a ...
Details for: Burkitt's lymphoma : › WHO HQ Library catalog
Acute left ventricular insufficiency in a Burkitt Lymphoma patient with myocardial involvement and extensive local tumor cell...
Myocardial lymphoma involvement receded completely during the following two therapy cycles, while cardiac function periodically ... Although rare, cardiac involvement in BL can quickly become life-threatening due to rapid lymphoma doubling time and should ... While additional studies are needed to further elucidate the mechanisms of acute cardiac insufficiency due to lymphoma lysis in ... Interestingly, the decline in cardiac function lessened with decreasing myocardial lymphoma manifestation. Once the ...
About Us - Burkitt's Lymphoma Society
Burkitts Like lymphoma, Burkitts lymphoma or Diffuse Large B-Cell lymphoma? * "You have Burkitts lymphoma, but it is one of ... Burkitts Lymphoma Society is a support and advocacy non-profit organization.. Burkitts lymphoma is a rare and aggressive form ... Burkitts Lymphoma Society. We are a support and advocacy non-profit organization for Burkitts Lymphoma patients and ... with encouraging insights only available from people who have been through the treatments for Burkitts lymphoma. ...
BLGSP - Foundation for Burkitt Lymphoma
Burkitt Lymphoma Genome Sequencing Project. The Burkitt Lymphoma Genome Sequencing Project (BLGSP) is an ongoing multi-site, ... National Cancer Institute Office of Cancer Genomics as a public-private partnership with the Foundation for Burkitt Lymphoma ... may help to distinguish the anatomic and pathological differences in patients with endemic versus sporadic Burkitt Lymphoma. He ... How Results of the BLGSP Could Be Useful for Other Lymphoma and Cancers:. ...
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma
Non-Hodgkin lymphoma (NHL) is a collective term for a heterogeneous group of lymphoproliferative malignancies with differing ... Burkitt lymphoma. Normal architecture is entirely replaced by lymphoma cells and evenly dispersed macrophages, starry sky (250 ... of MCLs but is negative in all other B-cell lymphoid neoplasms except Burkitt lymphomas and lymphoblastic lymphomas ... Burkitt Lymphoma. Classification. The 2008 World Health Organization classification identifies the following three clinical ...
Burkitt Lymphoma in Children | Northwestern Medicine
Clinical and tomographic findings of Burkitt's lymphoma in pediatric patients - case report
Palavras-chave : Burkitt Lymphoma; Lymphoma Non-Hodgkin; Mouth Neoplasms.. · resumo em Português · texto em Português · pdf em ... Burkitts lymphoma is characterized as being a non-Hodgkins Lymphoma undifferentiated B cells with highly aggressive character ... In this paper we aim to report a case of Burkitts lymphoma in a child of 4 years old, explaining its clinical, tomographic and ... Clinical and tomographic findings of Burkitts lymphoma in pediatric patients - case report. Rev. cir. traumatol. buco-maxilo- ...
Boy with Burkitt's lymphoma | Life on Earth Pictures
The boy suffers from Burkitts lymphoma, a cancer of the lymphatic system caused by the Epstein-Barr virus. ... Africa Tanzania health disease tropical disease woman African Tanzanian child boy non-Hodgkins lymphoma Burkitts lymphoma ... Boy with Burkitts lymphoma. Add to Cart Add to Lightbox Download Dr. Rina Luhaga examines Filbert Mabula as his mother Rahabu ... The boy suffers from Burkitts lymphoma, a cancer of the lymphatic system caused by the Epstein-Barr virus. ...
Non Hodgkins, B-cell, Burkitt's Lymphoma and me | robinbtaylor
HomeNon Hodgkins, B-cell, Burkitts Lymphoma and me Non Hodgkins, B-cell, Burkitts Lymphoma and me. December 22, 2014. June 3 ... 22 thoughts on "Non Hodgkins, B-cell, Burkitts Lymphoma and me" * Rosalind says: ... Non Hodgkins, B-cell, Burkitts lymphoma and me *Jump to the beginning ... Non Hodgkins, B-cell, Burkitts lymphoma and me *Jump to the beginning ...
true of BURKITT'S LYMPHOMA-UKMLA PLAB AMC USMLE Prometric MCQ
Burkitt Lymphoma in Children | UCLA Health Library, Los Angeles, CA
BURKITT'S LYMPHOMA - WHAT IS NEW? | Abinya | East African Medical Journal
Burkitt Lymphoma | Chemotherapy - treatment in Germany . Hospital Prices, Ranking, Reviews - Bookinghealth
Chemotherapy in Burkitt lymphoma - treatment in Germany ★ Direct prices from the best hospitals in Germany $ We will help you ... Burkitt Lymphoma - Chemotherapy: treatment in the Best Hospitals of Germany ➤Chemotherapy in Burkitt lymphoma - treatment in ... Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes ... Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, ...
American Journal of Case Reports | Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level...
CONCLUSIONS:Primary CNS Burkitt lymphoma (PCNSBL) is a rare disease with no clear evidence in the literature of how to deal ... Over the past years, only a few cases of primary CNS Burkitt lymphoma were reported. There is a challenge in early recognition ... We introduce a case of a 65-year-old who presented with fluctuating memory disturbance diagnosed as cerebral Burkitt lymphoma. ... Furthermore, there is no specific treatment protocols for primary CNS Burkitt lymphoma, which adds to the difficulty in ...