Burkitt lymphoma. Medical search

A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

A general term for various neoplastic diseases of the lymphoid tissue.

A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.

B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.

Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.

Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.

The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.

A PYRIDOXAL PHOSPHATE-containing enzyme that catalyzes the transfer of a formyl group from L-GLUTAMATE to N-formimidoyl-L-glutamate and TETRAHYDROFOLATE. This enzyme may also catalyze formyl transfer from 5-formyltetrahydrofolate to L-GLUTAMATE. This enzyme was formerly categorized as EC 2.1.2.6.

Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.

Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).

A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.

A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.

A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.

A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.

Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.

Antibodies obtained from a single clone of cells grown in mice or rats.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.

The large, metacentric human chromosomes, called group A in the human chromosome classification. This group consists of chromosome pairs 1, 2, and 3.

Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).

A cell line derived from cultured tumor cells.

Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Established cell cultures that have the potential to propagate indefinitely.

SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.

A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.

A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.

Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.

Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.

The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Antibodies produced by a single clone of cells.

An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.

Substances elaborated by viruses that have antigenic activity.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.

Disorders characterized by proliferation of lymphoid tissue, general or unspecified.

DNA present in neoplastic tissue.

Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).

Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.

Mapping of the KARYOTYPE of a cell.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.

Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.

Therapeutic act or process that initiates a response to a complete or partial remission level.

An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

Deoxyribonucleic acid that makes up the genetic material of viruses.

A group II chaperonin found in eukaryotic CYTOSOL. It is comprised of eight subunits with each subunit encoded by a separate gene. This chaperonin is named after one of its subunits which is a T-COMPLEX REGION-encoded polypeptide.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.

Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)

Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL) cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other EBV-positive BL cells express a restricted set of EBV gene products (type I latency) that are not known to overtly affect cell growth. Here we demonstrate that reestablishment of type I latency in EBV-negative Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resistance to apoptosis under growth-limiting conditions. The antiapoptotic effect of EBV was associated with a higher level of Bcl-2 expression and an EBV-dependent decrease in steady-state levels of c-MYC protein. Although the EBV EBNA-1 protein is expressed in all EBV-associated tumors and is reported to have oncogenic potential, enforced expression of EBNA-1 alone in EBV-negative Akata cells failed to restore tumorigenicity or EBV-dependent down-regulation of c-MYC. These data provide direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a novel model whereby a restricted latency program of EBV promotes B-cell survival, and thus virus persistence within an immune host, by selectively targeting the expression of c-MYC. (+info)

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)

CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels. (+info)

Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)

Bruton's tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B cells is still unclear. This study represents a search for the substrate for Btk in vivo. We identified one of the major phosphoproteins associated with Btk in the preB cell line NALM6 as the Wiskott-Aldrich syndrome protein (WASP), the gene product responsible for Wiskott-Aldrich syndrome, which is another hereditary immunodeficiency with distinct abnormalities in hematopoietic cells. We demonstrated that WASP was transiently tyrosine-phosphorylated after B-cell antigen receptor cross-linking on B cells, suggesting that WASP is located downstream of cytoplasmic tyrosine kinases. An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk. A protein binding assay suggested that the tyrosine-phosphorylation of WASP alters the association between WASP and a cellular protein. Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown. (+info)

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)

In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-crossblocking pairs), polyclonal anti-mu Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fab', F(ab')2 and F(ab')3 derivatives from anti-Fc mu mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (C mu2-C mu4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-Fd mu, or C mu1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb. (+info)

Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)

Ligation of CD40 on the surface of B cells induces multiple phenotypic effects, many of which are mimicked by the EBV latent membrane protein 1 (LMP1) through its interaction with downstream components of the CD40 signaling pathway. Because the effects of LMP1 have been most closely studied in human Burkitt Lymphoma (BL) cell lines retaining a tumor biopsy-like phenotype in vitro, we have examined the response of a panel of such lines to CD40 ligation. Two distinct patterns of response were observed that were unrelated to the surface level of CD40 or to the EBV genome status of the lines. Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition. Aggregation was seen at lower doses than those required to elicit the other effects. By contrast, low responder (LR) lines showed no detectable response to CD40 mAbs, while their responses to sCD40L were limited to activation of NF-kappa B and up-regulation of CD95 only. However, in transfection experiments, LMP1 uniformly induced the full spectrum of phenotypic effects in both HR and LR lines. We conclude that some BL cell lines show a highly restricted response to CD40 ligation but remain fully susceptible to LMP1. (+info)

Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)

Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans. (+info)

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)

The consistent presence of EBV genomes in certain tumor types (in particular, AIDS-related central nervous system lymphomas and nasopharyngeal carcinomas) may allow novel, EBV-based targeting strategies. Tumors contain the latent (transforming) form of EBV infection. However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce lytic EBV infection, resulting in death of the host cell. We have constructed replication-deficient adenovirus vectors expressing the BZLF1 or BRLF1 immediate-early genes and examined their utility for killing latently infected lymphoma cells in vitro and in vivo. We show that both the BZLF1 and BRLF1 vectors efficiently induce lytic EBV infection in Jijoye cells (an EBV-positive Burkitt lymphoma cell line). Furthermore, lytic EBV infection converts the antiviral drug, ganciclovir (GCV), into a toxic (phosphorylated) form, which inhibits cellular as well as viral DNA polymerase. When Jijoye cells are infected with the BZLF1 or BRLF1 adenovirus vectors in the presence of GCV, viral reactivation is induced, but virus replication is inhibited (thus preventing the release of infectious EBV particles); yet cells are still efficiently killed. Finally, we demonstrate that the BZLF1 and BRLF1 adenovirus vectors induce lytic EBV infection when they are directly inoculated into Jijoye cell tumors grown in severe combined immunodeficiency mice. These results suggest that induction of lytic EBV infection in tumors, in combination with GCV, may be an effective strategy for treating EBV-associated malignancies. (+info)

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)

In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene becomes transcriptionally activated as a consequence of the chromosomal translocation and shows preferential usage of promoter P1 over P2, a phenomenon referred to as promoter shift. In order to define the responsible regulatory elements within the Ig lambda locus, we studied the effect of the human Ig lambda enhancer (HuE lambda) on c-myc expression after stable transfection into BL cells. A 12 kb genomic fragment encompassing HuE lambda, but not HuE lambda alone, strongly activated c-myc expression and induced the promoter shift. To identify additional elements involved in c-myc deregulation, we mapped DNaseI hypersensitive sites within the 12 kb lambda fragment on the construct. Besides one hypersensitive site corresponding to HuE lambda, three additional sites were detected. Two of these elements displayed enhancer activity after transient transfection. The third element did not activate c-myc transcription, but was required for full c-myc activation and promoter shift. Deletion analyses of the c-myc promoter identified the immediate promoter region as sufficient for activation by the Ig lambda. locus, but also revealed that induction of the promoter shift requires additional upstream elements. (+info)

... causing excessive proliferation observed as Burkitt's lymphoma. Burkitt's lymphoma commonly affects the jaw bone, forming a ... Burkitt's lymphoma is a type of Non-Hodgkin's lymphoma and is most common in equatorial Africa and is co-existent with the ... Nasopharyngeal cancer Several Non-Hodgkin's lymphomas, including Burkitt's lymphoma and primary cerebral lymphoma Post- ... Burkitt's lymphoma, and Epstein Barr virus positive diffuse large B-cell lymphoma, not otherwise specified); 2) non-lymphoid ...

https://en.wikipedia.org/wiki/Epstein–Barr_virus_infection

MAOA Burkitt's lymphoma; 113970; MYC Buschke-Ollendorff syndrome; 166700; LEMD3 C syndrome; 211750; CD96 C5 deficiency; 609536 ... FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin's lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

"Peter Saint John". Burkitt's Lymphoma Society. 2013. Archived from the original on June 9, 2017. Retrieved June 9, 2017. "In ...

https://en.wikipedia.org/wiki/Bozoma_Saint_John

Burkitt, D. P. (1971). "Epidemiology of Burkitt's Lymphoma". Proceedings of the Royal Society of Medicine. 64 (9): 909-910. doi ... Other notable work included relating the incidence of Burkitt's lymphoma to climatic conditions and the discovery of several ... Haddow's most prominent work was considered to be that on yellow fever and Burkitt's lymphoma. The Zika virus has since emerged ...

https://en.wikipedia.org/wiki/Alexander_John_Haddow

Peng SL, Cheng CN, Chang KC (2007). "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682-3. doi: ...

https://en.wikipedia.org/wiki/Azzopardi_phenomenon

Burkitt lymphoma (BL); Hodgkin lymphoma (HL); plasmablastic lymphoma (PBL); and primary effusion lymphoma (PEL) (also termed ... Burkitt lymphoma occurs in three forms. Epidemic Burkitt lymphoma (eBL) is common in Africa, the Middle East, Brazil, Papua New ... Two extremely rare types of the intravascular lymphomas, intravascular NK-cell lymphoma and intravascular T- cell lymphoma, are ... angioimmunoblastic T-cell lymphoma (AITL), and anaplastic lymphoma kinase positive or negative anaplastic large-cell lymphoma ( ...

https://en.wikipedia.org/wiki/Epstein–Barr_virus-associated_lymphoproliferative_diseases

Denis Parsons Burkitt first describes Burkitt's lymphoma. February 7 - Discovery of "Deep Skull" in Niah Caves in Sarawak by ... synd/2511 at Who Named It? Burkitt, D. (1958). "A sarcoma involving the jaws in African children". The British Journal of ...

https://en.wikipedia.org/wiki/1958_in_science

Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma). Non-coding RNAs (ncRNAs) have a role in this process. ... of endemic Burkitt's lymphoma. Splicing of these W repeat transcripts produces a short intron and a long intron (Fig. 1), both ... "An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt ...

https://en.wikipedia.org/wiki/Epstein–Barr_virus_stable_intronic-sequence_RNAs

Anthony Yeo, 60, Singaporean counsellor, Burkitt's lymphoma. Gilda Galán, 92, Puerto Rican actress. Lorena Gale, 51, Canadian ... Alan Berkman, 63, American physician and activist, lymphoma. Fleur Cowles, 101, American writer, editor and artist. Baciro Dabó ... Bob Bogle, 75, American guitarist (The Ventures), non-Hodgkin lymphoma. Angela Coughlan, 56, Canadian swimmer, bronze medalist ... Luo Jing, 48, Chinese news presenter, lymphoma. Adilgerei Magomedtagirov, 53, Russian general, Interior Minister for the ...

https://en.wikipedia.org/wiki/Deaths_in_June_2009

Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt's lymphoma samples by ... Epstein, M.A; Achong, B.G; Barr, Y.M (1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". The Lancet. ... Epstein, Anthony (2012-03-01). "Burkitt lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology. 156 ... "Morphological and Biological Studies on a Virus in Cultured Lymphoblasts from Burkitt's Lymphoma". Journal of Experimental ...

https://en.wikipedia.org/wiki/Bert_Achong

Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...

https://en.wikipedia.org/wiki/History_of_cancer

... she was treated for Burkitt's lymphoma. She was treated with aggressive chemotherapy including intrathecal chemotherapy at City ... The cause of lymphoma was prior chemotherapy from 2008 for breast cancer. In 2013, Gujral was in remission from both cancers. ... Lisa Tsering (2013-08-06). "Actress fights lymphoma Urges Community Awareness". India West. Archived from the original on 2013- ...

https://en.wikipedia.org/wiki/Namrata_Singh_Gujral

Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964-03-28). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma". ...

https://en.wikipedia.org/wiki/1964_in_science

Overexpression of QSER1 was noted in Burkitt's Lymphoma. QSER1 expression also increases with increasing Gleason score (more ... Altered expression of QSER1 is noted in pathological cardiomyopathy, Burkitt's Lymphoma, prostate cancer, and some breast ...

https://en.wikipedia.org/wiki/QSER1

Nick Venet, 61, American record producer, Burkitt's lymphoma. Wayne Ambler, 82, American baseball player. Eddie Campagnuolo, 70 ... Sally Purcell, 53, British poet and translator, lymphoma of brain cells. Mae Questel, 89, American actress, Alzheimer's disease ...

https://en.wikipedia.org/wiki/Deaths_in_January_1998

In 1964 Anthony Epstein, Bert Achong and Yvonne Barr identified the first human oncovirus from Burkitt's lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... Infectious causes of cancer Carcinogen Oncogenic Oncogene Adult T-cell leukemia/lymphoma Cancer bacteria Oncolytic virus, a ... B-cell non-Hodgkin's lymphoma, and cancer". World Journal of Hepatology. 7 (3): 327-43. doi:10.4254/wjh.v7.i3.327. ISSN 1948- ...

https://en.wikipedia.org/wiki/Oncovirus

EBV has also been implicated in several other diseases, including Burkitt's lymphoma, Hodgkin's lymphoma, stomach cancer, ... 2014). "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... and hydroa vacciniforme as well as malignant lymphoproliferative diseases such as Epstein-Barr virus-positive Burkitt lymphoma ...

https://en.wikipedia.org/wiki/Epstein–Barr_virus

... primary leptomeningeal lymphoma, diffuse large cell lymphoma,[non-primary source needed] MALT lymphoma, and Burkitt's lymphoma ... Shimano S, Murata N, Tsuchiya J (July 1997). "[Idiopathic CD4+ T-lymphocytopenia terminating in Burkitt's lymphoma]". Rinsho ... Campbell JK, Prince HM, Juneja SK, Seymour JF, Slavin M (April 2001). "Diffuse large cell lymphoma and t(8;22) (q24;q11) in a ... Lymphoma. 41 (3-4): 421-3. doi:10.3109/10428190109057998. PMID 11378556. S2CID 23366810. Longo F, Hébuterne X, Michiels JF, ...

https://en.wikipedia.org/wiki/Idiopathic_CD4 _lymphocytopenia

He was the first to describe a type of cancer that now bears his name Burkitt's lymphoma. This type of cancer was endemic in ... ISBN 978-1-904455-03-5. Bornkamm GW (April 2009). "Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more ... Magrath I (September 2009). "Lessons from clinical trials in African Burkitt lymphoma". Current Opinion in Oncology. 21 (5): ... In an attempt to find a cause for the cancer, Burkitt sent cells from the tumour to Anthony Epstein (b. 1921) a British ...

https://en.wikipedia.org/wiki/History_of_virology

Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Burkitt's lymphoma, Hodgkin's lymphoma, Post-transplant lymphoproliferative disease and Nasopharyngeal carcinoma.[52]. ... 1964: Anthony Epstein, Bert Achong and Yvonne Barr identify the first human oncovirus from Burkitt lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...

https://en.wikipedia.org/wiki/Tumor_viruses

He died on 2 January 1998 of Burkitt's lymphoma. He is survived by his wife, actress Valerie Kairys Venet, and their son, ...

https://en.wikipedia.org/wiki/Nick_Venet

In February 2012, Couchey was diagnosed with Burkitt's lymphoma. The aggressive cancer took hold quickly, and Couchey died on ...

https://en.wikipedia.org/wiki/Sid_Couchey

The most frequently discussed example of c-Myc as a proto-oncogene is its implication in Burkitt's lymphoma. In Burkitt's ... A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...

https://en.wikipedia.org/wiki/Myc

Report of two cases, one simulating a Burkitt lymphoma". Acta Cytol. 34 (2): 265-8. PMID 2157324.CS1 maint: multiple names: ... Tumour cells in peripheral blood may look similar to circulating blasts or lymphoma cells. Features that aid in distinguishing ... megakaryocytes or osteoclasts Leukemoid reaction Lymphoma The presence of tumour cells in the peripheral blood of a cancer ...

https://en.wikipedia.org/wiki/Carcinocythemia

CS1 maint: discouraged parameter (link) Epstein, A. (2012). "Burkitt Lymphoma and the discovery of Epstein-Barr virus". British ... Epstein was the first person to propose that Burkitt's lymphoma was a cancer caused by a virus. Upon hearing a lecture given by ... changed his research focus from cancer causing viruses in chickens to searching for a viral origin of Burkitt's lymphoma. After ... more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from them ...

https://en.wikipedia.org/wiki/Anthony_Epstein

... gene was first discovered in Burkitt lymphoma patients. In Burkitt lymphoma, cancer cells show chromosomal translocations, ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ... and tumorigenicity in Burkitt's lymphoma". Current Topics in Microbiology and Immunology. 258: 153-60. PMID 11443860.. ...

https://en.wikipedia.org/wiki/C-myc

Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... EBV has also been implicated in several other diseases, including Burkitt's lymphoma,[42] Hodgkin's lymphoma,[43] stomach ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and Cancer. 9 ( ...

https://en.wikipedia.org/wiki/Epstein-Barr

Also seen in chronic lymphocytic leukemia, Hodgkin's Lymphoma, Burkitt's Lymphoma. Carbone PP, Kaplan HS, Musshoff K, Smithers ... B symptoms are a clear negative prognostic factor in Hodgkin lymphoma. The relevance of B symptoms in non-Hodgkin lymphoma is ... and weight loss which can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. The presence or absence of B ... B symptoms are so called because Ann Arbor staging of lymphomas includes both a number (I-IV) and a letter (A or B). "A" ...

https://en.wikipedia.org/wiki/B_symptoms

C. O. Povlsen, J. Rygaard: Effects of Cyclophosphamide (Endoxan R) on a Burkitt´s Lymphoma serially grown in nude mice. In: ... Mit der Behandlung des bei der Nacktmaus transplantierten Burkitt-Lymphoms wurde 1974 erstmals ein neuer Weg in der ...

https://de.m.wikipedia.org/wiki/Nacktmaus

Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...

https://en.wikipedia.org/wiki/Jc_virus

Burkitt's lymphoma ... B-cell lymphoma - B cells - B lymphocytes (B cells) - ... non-Hodgkin's lymphoma (NHL) - non-nucleoside reverse transcriptase inhibitors (NNRTI) - non-steroidal anti-inflammatory drugs ...

https://en.m.wikipedia.org/wiki/Index_of_AIDS-related_topics

Daniels VG, Wheater PR, Burkitt HG (1979). Functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone. ... Of the various tumors of the blood and lymph, cancers of WBCs can be broadly classified as leukemias and lymphomas, although ...

https://en.wikipedia.org/wiki/Immune_cell

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...

https://en.wikipedia.org/wiki/Mosaicism

2002). "EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma". Curr. Top. Microbiol. Immunol. 258: 153-60. ... Iijima S, Teraoka H, Date T, Tsukada K (1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation ... initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas". ...

https://sh.wikipedia.org/wiki/Myc

Rochford, Rosemary; Moormann, Ann M. (2015). «Burkitt's Lymphoma». Epstein Barr Virus Volume 1. Current Topics in Microbiology ... Burkitt-lymfekreft eller Burkitt-lymfom er ein lymfekreft frå B-seller. Sjukdomen er i mange tilfelle knytt til både Epstein- ... Casulo, Carla; Friedberg, Jonathan (2015). «Treating Burkitt Lymphoma in Adults». Current Hematologic Malignancy Reports 10 (3 ... Burkitt-lymfekreft vart fyrst skildra av den britiske kirurgen Dennis Burkitt i 1958 frå pasientar i Kampala i Uganda. Epstein- ...

https://nn.wikipedia.org/wiki/Burkitts_lymfom

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...

https://en.wikipedia.org/wiki/Monosomy_9p

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...

https://en.wikipedia.org/wiki/Jacobsen_syndrome

B21.1) HIV disease resulting in Burkitt's lymphoma. *(B21.2) HIV disease resulting in other types of non-Hodgkin's lymphoma ...

https://hi.wikipedia.org/wiki/आइसीडी-१०_अध्याय_ब

Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... mature B-cell ALL (Burkitt leukemia - FAB L3) An extensive panel of monoclonal antibodies to cell surface markers, particularly ... Infectious mononucleosis, acute myeloid leukemia, lymphoblastic lymphoma, aplastic anemia[3]. Treatment. Chemotherapy, stem ... August 2005). "Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas". ...

https://en.m.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

On May 30, 2007, Andruzzi was diagnosed with non-Hodgkin's Burkitt's lymphoma, predicted to double in size in just 24 hours.[1] ...

https://en.wikipedia.org/wiki/Joe_Andruzzi

Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... of all cases of lymphomas in HIV infections (other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ... a b Primary CNS Lymphoma~treatment at eMedicine *^ Omuro, A; et al. (26 February 2015). "R-MPV followed by high-dose ...

https://en.wikipedia.org/wiki/CNS_lymphoma

Ruf IK, Rhyne PW, Yang H, et al., EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma, in Curr. Top. ... Iijima S, Teraoka H, Date T, Tsukada K, DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc ... Il gene Myc fu scoperto per la prima volta in pazienti affetti da linfoma di Burkitt. In questa neoplasia le cellule tumorali ... initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas, in ...

https://it.m.wikipedia.org/wiki/Myc_

Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...

https://si.wikipedia.org/wiki/කොවිඩ්-19

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ... and lymphoma) before age five have been established. However, further research is needed to confirm these findings. Little is ...

https://en.wikipedia.org/wiki/Congenital_disorder

Denis Parsons Burkitt (1911-1993), doctor, discoverer of Burkitt's lymphoma. *Roy Carroll (born 1977), association footballer ...

https://en.wikipedia.org/wiki/County_Fermanagh

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ... and lymphoma) before age five have been established. Little is currently known about how paternal smoking damages the fetus, ...

https://en.wikipedia.org/wiki/Birth_defects

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...

https://en.wikipedia.org/wiki/Ring_chromosome_18

Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... "HCV syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin's lymphoma, and cancer ...

https://en.wikipedia.org/wiki/Hepatitis_C_virus

Kræftformerne B-celle lymphoma, T-celle lymphoma, Hodgkin lymphoma, Burkitt's lymphoma, mavekræft og nasopharyngeal carcinoma ...

https://da.wikipedia.org/wiki/Vira_

伯基特淋巴瘤（英语：Burkitt's lymphoma）. 霍奇金淋巴瘤. 濾泡性樹突狀細胞肉瘤（英语：Follicular dendritic cell sarcoma）. Extranodal NK/T-cell lymphoma, nasal ... 脾邊緣淋巴瘤（英语：Splenic marginal zone lymphoma）. 人類嗜T淋巴球病毒一型成人T細胞白血病/淋巴瘤（英语：Adult T-cell leukemia/lymphoma）. ... type（英语：Extranodal NK/T

https://zh.wikipedia.org/wiki/HPV

Burkitt's lymphoma t(8 MYC;14 IGH). *Follicular lymphoma t(14 IGH;18 BCL2) ...

https://en.wikipedia.org/wiki/Confined_placental_mosaicism

Burkitt's lymphoma. *Burn-Goodship syndrome. *Burnett-Schwartz-Berberian syndrome. *Burning mouth syndrome- Type 3 ...

https://en.wikipedia.org/wiki/List_of_diseases_

Angioimmunoblastic T-cell lymphoma. *B-cell prolymphocytic leukemia. *Burkitt's lymphoma. *Chronic lymphocytic leukemia ... Lymphoma and leukemia: These two classes of cancer arise from cells that make blood. Leukemia is the most common type of cancer ... in children accounting for about 30%.[2] However, far more adults develop lymphoma and leukemia. ...

https://en.wikipedia.org/wiki/List_of_cancer_types

... potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo". Cancer Biology & Therapy. 4 (5 ...

https://en.wikipedia.org/wiki/COX_inhibitor

Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ...

https://en.wikipedia.org/wiki/Avian_Flu

Burkitt's lymphoma, Primary central nervous system lymphoma) · MCPyV (Merkel cell cancer) · SV40 ... RNA virus: HCV (Hepatocellular carcinoma) · HTLV-I (Adult T-cell leukemia/lymphoma) ...

https://bn.wikipedia.org/wiki/নিপাহ_ভাইরাস_সংক্রমণ

"A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells". Proceedings of the National Academy of ...

https://en.wikipedia.org/wiki/Dna

Burkitts lymphoma. Hodgkins lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ... Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Unique genetic alterations promote cell survival in Burkitt lymphoma, distinct from other types of lymphoma.[21] These TCF3 and ...

https://en.wikipedia.org/wiki/Burkitt%27s_lymphoma

... is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B-cell lymphoma or small noncleaved cell lymphoma. ... Burkitts lymphoma. Definition. Burkitts lymphoma (BL) is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B- ... Non-Hodgkins lymphoma (NHL). -One of two major subdivisions of lymphomas. Burkitts lymphoma is a subcategory of NHL. ... Burkitts lymphoma was first described in 1957 by Denis Parsons Burkitt, an Irish surgeon. While this type of lymphoma is still ...

https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/burkitt-lymphoma

recognized as the fastest growing human tumor, burkitt lymphoma is associated with impaired ... burkitt lymphoma is a form of non-hodgkins lymphoma in which cancer starts in immune cells called b-cells. ... What is Burkitt lymphoma?. ANSWER Burkitt lymphoma is a form of non-Hodgkins lymphoma in which cancer starts in immune cells ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ...

https://www.webmd.com/cancer/lymphoma/qa/what-is-burkitt-lymphoma

if burkitt lymphoma is suspected, all or part of an enlarged lymph node or other suspicious disease site will be biopsied. in a ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... How is Burkitt lymphoma diagnosed?. ANSWER If Burkitt lymphoma is suspected, all or part of an enlarged lymph node or other ...

https://www.webmd.com/cancer/lymphoma/qa/how-is-burkitt-lymphoma-diagnosed

Histology of Burkitts lymphoma.. Br Med J 1971; 1 doi: https://doi.org/10.1136/bmj.1.5750.669-a (Published 20 March 1971) Cite ...

http://www.bmj.com/content/1/5750/669.2

Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis. Burkitt lymphoma can be divided into three main ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ... Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Non-Hodgkin lymphoma, which includes Burkitt, accounts for 30-50% of childhood lymphoma. The jaw is less commonly involved, ...

https://en.wikipedia.org/wiki/Burkitt_lymphoma

Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, Virginia Three cases of Burkitts lymphoma (BL) have occurred ... editorial note: Burkitts lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it ... Brubaker G, Geser A, Pike MC: Burkitts lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of ... Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of American Burkitts Lymphoma in neighbors. N Engl J Med 288: ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00048532.htm

Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn ... Burkitt-like lymphoma is grouped with Burkitt lymphoma.. Subtypes of Burkitt lymphoma. There are 3 subtypes of Burkitt lymphoma ... Burkitt lymphoma. Burkitt lymphoma is a type of mature B-cell non-Hodgkin lymphoma (NHL). Burkitt lymphoma develops most often ... Sporadic Burkitt lymphoma is also called non-African, or non-endemic, Burkitt lymphoma. It is the most common type of Burkitt ...

https://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/burkitt-lymphoma/?region=nu

Learn about the survival rates of non-Hodgkin lymphoma cancer in children including lymphoblastic, Burkitt, and large cell ... Burkitt and Burkitt-like lymphoma Treatment of limited stage (stage I and II) Burkitt lymphomas is usually very successful, ... The long-term survival rate for children with more advanced (stage III or IV) Burkitt lymphoma ranges from about 80% to 90%. ... Large cell lymphomas The long-term survival rate is over 90% for limited stage (stage I and II) diffuse large B-cell lymphomas ...

https://www.cancer.org/cancer/childhood-non-hodgkin-lymphoma/detection-diagnosis-staging/survival-rates.html

D. Burkitt, "Burkitts lymphoma outside the known endemic areas of Africa and New Guinea," International Journal of Cancer, vol ... Orbital Burkitts Lymphoma: An Aggressive Presentation. Gian Paolo Giuliari,1,2,3 Ama Sadaka,4 Maria Angelica Cortez,1,3 and ... D. Burkitt and G. T. OConor, "Malignant lymphoma in African children. I. A clinical syndrome," Cancer, vol. 14, pp. 258-269, ... I. K. Ruf, P. W. Rhyne, H. Yang et al., "Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma ...

https://www.hindawi.com/journals/criopm/2012/354043/ref/

... a non-Hodgkins lymphoma of B cell origin that occurs especially in children of central Africa and is associated with Epstein- ... Comments on Burkitts lymphoma. What made you want to look up Burkitts lymphoma? Please tell us where you read or heard it ( ... Time Traveler for Burkitts lymphoma. The first known use of Burkitts lymphoma was in 1963. See more words from the same year ... History and Etymology for Burkitts lymphoma. Denis Parsons Burkitt †1993 British surgeon ...

https://www.merriam-webster.com/dictionary/Burkitt%27s%20lymphoma

Duodenal involvement of Burkitt lymphoma is extremely rare and accounts for , 1% of all lymphomas. We present a case report of ... Burkitt lymphoma is a malignancy that has commonly presented in GI tract but rarely in the duodenum. This clinical variant can ... Most non-Hodgkin lymphoma tumors involve extra nodal sites like the nervous system and gastrointestinal tract. A rare variant ... an older patient with a duodenal Burkitt lymphoma diagnosed by biopsy. A high suspicion should be present while treating ...

https://www.hindawi.com/journals/crigm/2019/7313706/

Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult ... Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas. Burkitts lymphoma: single-centre experience with modified ... Overview of Burkitts Lymphoma. ABOUT Lymphomas:. Overview of genes and cancer. Lymphoma is a cancer. About Lymphoma - general ... Burkitt-like lymphoma of T-cell type ncbi.nlm.nih.gov The Burkitt-like lymphomas bloodjournal.hematologylibrary.org. Southwest ...

http://lymphomation.org/type-burkitts.htm

in children, in the jaw, eyes, and internal organs: it is associated with the Epstein-Barr virusOrigin of Burkitts ... Burkitts lymphoma definition: a cancer characterized by tumors containing lymphoid cells, occurring esp. ... Burkitts lymphoma. Bur·kitts lymphoma. a cancer characterized by tumors containing lymphoid cells, occurring esp. in children ... "Burkitt\s lymphoma." YourDictionary, n.d. Web. 19 January 2019. ,https://www.yourdictionary.com/burkitt-s-lymphoma,. ...

https://www.yourdictionary.com/burkitt-s-lymphoma

Microgeographic variations in Burkitts lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr ... Microgeographic variations in Burkitts lymphoma. Study Abstract. BACKGROUND:. Endemic Burkitts lymphoma (eBL) has been ... Microgeographic variations in Burkitts lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr ...

https://www.wellnessresources.com/studies/microgeographic-variations-in-burkitts-lymphoma

A Ugandan autopsy specimen from a 4 year old african girl admitted with tumour of the jaw. She died two days after admission. The specimen shows extensive destruction by soft,haemorrhagic tumour of both mandibular rami with extension into the adjacent soft tissues. Tumour was also present in the liver, thyroid, spleen, kidneys, ovaries and abdominal lymph nodes.

https://www.thenakedscientists.com/podcasts/video-podcasts/naked-pathology/infectious-disease-lymphoreticular-burkitt-lymphoma

Burkitts lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the ... Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.. Schmitz R1, Young RM, Ceribelli ... Targeted therapies: New targets in Burkitt lymphoma? [Nat Rev Clin Oncol. 2012] ... a, Fre quencies of TCF3 and ID3 mutations in different lymphoma subtypes. b, TCF3 missense mutations in the E47 isoform in BL, ...

https://www.ncbi.nlm.nih.gov/pubmed/22885699

Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. It causes the cells in the lymphatic system to ... Burkitt Lymphoma. Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. It causes the cells in the ... Molecular Epidemiology to Detect Tumor Precursors in Children at Risk for Endemic Burkitts Lymphoma ... The Impact Of CD56neg NK Cells in the Pathogenesis of Endemic Burkitt Lymphoma ...

https://www.alexslemonade.org/childhood-cancer/types/burkitt-lymphoma

PubMed journal article Burkitts lymphoma: clinicopathologic features and differential diagnosi were found in PRIME PubMed. ... Burkitts type in the Working Formulation, Burkitts lymphoma and high-grade B-cell lymphoma, Burkitt-like in the REAL ... Burkitts type in the Working Formulation, Burkitts lymphoma and high-grade B-cell lymphoma, Burkitt-like in the REAL ... Burkitts lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in ...

https://www.unboundmedicine.com/medline/citation/16614233/Burkitt

Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To ... Apoptoseresistenz ist einer der Gründe für ein Versagen von Chemotherapie bei vielen Krebserkrankungen, darunter das Burkitt ... Um die molekularen Mechanismen der Apoptoseresistenz aufzuklären, wurde die Apoptoseinduktion in 15 Burkitt-Lymphom-Zelllinien ... könnten eine weitere Möglichkeit zur Behandlung von resistenten Burkitt-Lymphomen darstellen.. ...

https://edoc.hu-berlin.de/handle/18452/16738

... type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. The disease may affect the jaw, ... There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). Sporadic Burkitt lymphoma ... and endemic Burkitt lymphoma occurs in Africa. Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients. ... Burkitt lymphoma listen (BER-kit lim-FOH-muh) An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most ...

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/burkitt-lymphoma

... or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by ... the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, ... encoded search term (Burkitt%20Lymphoma%20and%20Burkitt-like%20Lymphoma) and Burkitt Lymphoma and Burkitt-like Lymphoma What to ... Burkitt Lymphoma and Burkitt-like Lymphoma. Updated: Apr 08, 2016 * Author: Ali H Kanbar, MD; Chief Editor: Emmanuel C Besa, MD ...

https://emedicine.medscape.com/article/1447602-overview

2006 issue concerning the molecular diagnosis of Burkitts lymphoma, almost half the patients with Burkitts lymphoma were ... Diagnosis of Burkitts lymphoma in due time: a practical approach. Cogliatti, S. B.; Novak, U.; Henz, S.; Schmid, U.; Möller, P ... Genomic Diagnosis of Burkitts Lymphoma. Lin, Bryan T. // New England Journal of Medicine;9/7/2006, Vol. 355 Issue 10, p1064 A ... Genomic Diagnosis of Burkitts Lymphoma. Dave, Sandeep S.; Staudt, Louis M. // New England Journal of Medicine;9/7/2006, Vol. ...

http://connection.ebscohost.com/c/abstracts/66954903/burkitts-lymphoma-colon

Lymphoma. *Non-Hodgkin lymphoma. *Non-Hodgkin lymphoma diagnosis. *Non-Hodgkin lymphoma treatment. *Non-Hodgkin lymphoma ... "Our research focuses on a group of lymphomas driven by abnormal expression of a gene called MYC of which Burkitts lymphoma is ... "We have found that Burkitts lymphoma cells are highly dependent on a pro-survival protein called MCL-1 and that if we take ... "We hope our research will really help to progress the search for alternatives for patients with Burkitts lymphoma who are ...

https://www.leukaemia.org.au/stories/developing-new-treatments-for-burkitts-lymphoma/

Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times ... The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as ... A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody ... A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody ...

http://science.sciencemag.org/content/220/4596/509

Primary CNS involvement in Burkitts lymphoma is rare.. Keywords. Brain Mediastinum Cavernous sinus Burkitts lymphoma MRI ... Kalina P, Black K, Woldenberg R (1996) Burkitts lymphoma of the skull base presenting as cavernous sinus syndrome in early ... We report on this case because radiologists and clinicians should be alerted to identify sites of primary Burkitts lymphoma ... Burkitts lymphoma with bilateral cavernous sinus and mediastinal involvement in a child. ...

https://link.springer.com/article/10.1007%2Fs00247-003-1010-x

Burkitt lymphoma causing colocolonic intussusception. DISCUSSION. Burkitts lymphoma is a malignant, rapidly growing B-cell ... Intussusception caused by Burkitt lymphoma is extremely rare. However, Burkitt lymphoma is the most common cause of ... Burkitt lymphoma also encases the mesenteric vessels.2 The vascular encasement in Burkitt lymphoma differs from encasement seen ... Surgical resection of Burkitt lymphoma is not typically performed unless the entire mass can be resected or if the mass is ...

https://appliedradiology.com/Communities/Pediatric-Imaging/burkitt-lymphoma-causing-colocolonic-intussusception

As such, Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults. The disease ... Burkitt lymphoma. What every physician needs to know:. Burkitt Lymphoma is a rapidly progressive lymphoid malignancy requiring ... Other non-Hodgkin lymphoma (NHL) histologies need to be differentiated from Burkitt lymphoma. Diffuse large B-cell lymphoma ( ... Are you sure your patient has Burkitt lymphoma? What should you expect to find?. The endemic variant of Burkitt lymphoma ...

https://www.renalandurologynews.com/hematology/burkitt-lymphoma/article/597528/

... known as lymphomas. DCEGs work includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its ... known as lymphomas. DCEGs portfolio includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its ... Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) A large, multidisciplinary epidemiological effort ... Pooled Analysis of Studies of Non-Hodgkin Lymphoma A pooled analysis of case-control studies of non-Hodgkin lymphoma among men ...

https://dceg.cancer.gov/research/cancer-types/lymphoma-burkitt-hodgkin-non-hodgkin

[1] [2] The overall cure rate for Burkitt's lymphoma in developed countries is about 90%, but worse in low-income countries. (wikipedia.org)
Burkitt's lymphoma is uncommon in adults, where it has a worse prognosis . (wikipedia.org)
Burkitt's lymphoma (BL) is a type of non-Hodgkin's lymphoma (NHL) that is sometimes called a B-cell lymphoma or small noncleaved cell lymphoma. (encyclopedia.com)
Burkitt's lymphoma is one of the most rapidly growing forms of human cancer. (encyclopedia.com)
Burkitt's lymphoma was first described in 1957 by Denis Parsons Burkitt, an Irish surgeon. (encyclopedia.com)
The endemic form of Burkitt's lymphoma is characterized by rapid enlargement of the patient's jaw, loosening of the teeth, protruding eyeballs, or an abdominal tumor in the region of the kidneys or ovaries. (encyclopedia.com)
In adults, Burkitt's lymphoma frequently produces a bulky abdomen and may involve the liver, spleen, and bone marrow . (encyclopedia.com)
In Western countries, Burkitt's lymphoma is more common in male than in female children. (encyclopedia.com)
Between 40% and 50% of these cases are Burkitt's lymphoma. (encyclopedia.com)
In adults, Burkitt's lymphoma is again more common in males than in females. (encyclopedia.com)
Currently, about 2% of AIDS patients develop Burkitt's lymphoma. (encyclopedia.com)
Burkitt's lymphoma affects a part of the immune system known as the lymphatic or lymphoid system. (encyclopedia.com)
Burkitt's lymphoma involves the B-cell lymphocytes. (encyclopedia.com)
In 1982, researchers discovered an oncogene (a gene that can release cells from growth constraints, possibly converting them into tumors) in 90% of patients with Burkitt's lymphoma. (encyclopedia.com)
In the summer of 2000, researchers reported that a gene called the HMG-I/Y gene is also involved in the development of Burkitt's lymphoma. (encyclopedia.com)
In addition to translocations of genetic material, Burkitt's lymphoma is also associated with oncogenic viruses - the Epstein-Barr virus (EBV) in endemic Burkitt's and human immunodeficiency virus ( HIV ) in the sporadic form. (encyclopedia.com)
Currently, however, the precise role of EBV in Burkitt's lymphoma is still being investigated, because the virus is less common in patients outside Africa. (encyclopedia.com)
Histology of Burkitt's lymphoma. (bmj.com)
McClatchie S . Histology of Burkitt's lymphoma. (bmj.com)
Three cases of Burkitt's lymphoma (BL) have occurred since 1971 in young boys living in one residential section of Winchester, Virginia. (cdc.gov)
editorial note: Burkitt's lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it constitutes the most common tumor of childhood (2). (cdc.gov)
Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of 'American Burkitt's Lymphoma' in neighbors. (cdc.gov)
Brubaker G, Geser A, Pike MC: Burkitt's lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of time-space clustering in a high risk isolated rural area. (cdc.gov)
However, the almost ubiquitous presence of the virus in the epidemic variant of Burkitt's lymphoma suggests that it contributes to the development and/or progression of this variant. (wikipedia.org)
What made you want to look up Burkitt's lymphoma ? (merriam-webster.com)
Burkitt's lymphoma tends to occur most often in children and in adults with compromised immune systems. (lymphomation.org)
A novel approach to Burkitt's lymphoma, using a regimen designed for large B-cell lymphomas, led to complete remissions in all patients in a small study, investigators reported here. (lymphomation.org)
In a study of 19 patients with Burkitt's, the highly aggressive B-cell lymphoma, all 19 treated with dose-adjusted EPOCH with Rituxan (rituximab) had a complete remission, with few of the adverse events associated with standard chemotherapy for Burkitt's lymphoma, reported Kieron Dunleavy, M.D., of the National Cancer Institute in Bethesda, Md., and colleagues. (lymphomation.org)
An international evaluation of CODOX-M and CODOX-M alternating with IVAC in adult Burkitt's lymphoma: results of United Kingdom Lymphoma Group LY06 study. (lymphomation.org)
Endemic Burkitt's lymphoma (eBL) has been associated with Epstein-Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. (wellnessresources.com)
Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus. (wellnessresources.com)
Burkitt's lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL in developing countries, necessitating new strategies. (nih.gov)
Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (unboundmedicine.com)
Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. (unboundmedicine.com)
With the publication of the WHO Classification of Haematopoietic and Lymphoid Tumors, the nomenclature of this lymphoma has come full circle, and it is once again known simply as Burkitt's lymphoma. (unboundmedicine.com)
These efforts have led to the development of high-intensity, short-duration combination chemotherapy that has proven extremely effective for a high proportion of Burkitt's lymphoma patients. (unboundmedicine.com)
The differential diagnosis of Burkitt's lymphoma is broad, and precise diagnosis based on histologic, immunophenotypic, and genetic features remains the critical first step in planning appropriate therapy. (unboundmedicine.com)
TY - JOUR T1 - Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (unboundmedicine.com)
A1 - Ferry,Judith A, PY - 2006/4/15/pubmed PY - 2006/9/29/medline PY - 2006/4/15/entrez SP - 375 EP - 83 JF - The oncologist JO - Oncologist VL - 11 IS - 4 N2 - Burkitt's lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. (unboundmedicine.com)
An abstract of the article "Burkitt's Lymphoma of the Colon" by Ziad Salem, William DiGiacomo, and Joseph R. DePasquale is presented. (ebscohost.com)
Genomic Diagnosis of Burkitt's Lymphoma. (ebscohost.com)
A letter to the editor is presented in response to an article by Dave et al, published in the June 8, 2006 issue concerning the molecular diagnosis of Burkitt's lymphoma, almost half the patients with Burkitt's lymphoma were children. (ebscohost.com)
A letter to the editor is presented in response to comments on a study regarding the genomic diagnosis of Burkitt's lymphoma. (ebscohost.com)
Burkitt's lymphoma--Winchester, Virginia. (ebscohost.com)
Reports on three cases of Burkitt's lymphoma (BL) which have occurred since 1971 in young boys living in Winchester, Virginia. (ebscohost.com)
Raji revisited: cytogenetics of the original Burkitt's lymphoma cell line. (ebscohost.com)
Presents a letter to the editor on the cytogenics of the original Burkitt's lymphoma cell line. (ebscohost.com)
Diagnosis of Burkitt's lymphoma in due time: a practical approach. (ebscohost.com)
An abstract of the medical research presentation "Diagnosis of Burkitt's lymphoma in due time: a practical approach," by S. B. Cogliatti, U. Novak, S. Henz, U. Schmid, P. MÃ¶ller and T. F. E. Barth is presented. (ebscohost.com)
The curious case of the tumour virus: 50 years of Burkitt's lymphoma. (ebscohost.com)
A correction to the article "The Curious Case of the Tumour Virus: 50 Years of Burkitt's Lymphoma," by David A. Thorley-Lawson and Martin J. Allday is presented. (ebscohost.com)
The Leukaemia Foundation is funding research aimed at advancing treatment for a blood cancer called Burkitt's lymphoma (BL) , thanks to the generous support of a major donor who has survived this aggressive blood cancer. (leukaemia.org.au)
Our research focuses on a group of lymphomas driven by abnormal expression of a gene called MYC of which Burkitt's lymphoma is the most well-known example," said Dr Kelly. (leukaemia.org.au)
We have found that Burkitt's lymphoma cells are highly dependent on a pro-survival protein called MCL-1 and that if we take this protein away using genetic tricks in the laboratory, the lymphoma cells die very rapidly. (leukaemia.org.au)
More recently, we have tested the efficiency of a drug that targets MCL-1 in our pre-clinical models of lymphomas and found it to be very efficient at killing Burkitt's lymphoma cells, and the side-effects to healthy tissues appeared manageable," she said. (leukaemia.org.au)
We now want to generate pre-clinical models that allow us to test how efficient pharmacological MCl-1 inhibition is in primary biopsy samples from Burkitt's lymphoma patients and patients with other MYC-driven lymphomas and leukaemias ," said Dr Kelly. (leukaemia.org.au)
We hope our research will really help to progress the search for alternatives for patients with Burkitt's lymphoma who are unable to tolerate chemotherapy and those who relapse with this disease" said Dr Kelly. (leukaemia.org.au)
Biopsy of the mediastinal lesion identified Burkitt's lymphoma. (springer.com)
We report on this case because radiologists and clinicians should be alerted to identify sites of primary Burkitt's lymphoma outside of the central nervous system if clinical symptoms indicate, or imaging shows, CNS lesions. (springer.com)
Primary CNS involvement in Burkitt's lymphoma is rare. (springer.com)
Kalina P, Black K, Woldenberg R (1996) Burkitt's lymphoma of the skull base presenting as cavernous sinus syndrome in early childhood. (springer.com)
Burkitt's lymphoma is a malignant, rapidly growing B-cell neoplasm. (appliedradiology.com)
Burkitt's lymphoma (BL) is an aggressive blood cancer. (leukaemia.org.au)
Developing a novel anti-cancer drug for the treatment of aggressive Burkitt's Lymphoma is the title of their research project. (leukaemia.org.au)
Team Burkitt's Lymphoma 2017 is closed for new team members, but you can register for the event with a new team or join another team! (alexslemonade.org)
Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. (nih.gov)
S. Sariban-Sohraby, I. T. Magrath and R. S. Balaban, "Comparison of Energy Metabolism in Human Normal and Neoplastic (Burkitt's Lymphoma) Lymphoid Cells," Cancer Research, Vol. 43, No. 10, 1983, pp. 4662-4664. (scirp.org)
J. J. Glasheen and M. D. Sorensen, "Burkitt's Lymphoma Presenting with Lactic Acidosis and Hypoglycemia-A Case Presentation," Leukemia & Lymphoma, Vol. 46, No. 2, 2005, pp. 281-283. (scirp.org)
Side view of the face of a child showing a large tumour in the jaw due to Burkitt's lymphoma cancer. (sciencephoto.com)
Burkitt's lymphoma has a surprisingly large number of genetic mutations, a discovery that may speed treatment for this aggressive cancer that hits mainly African children. (nih.gov)
Burkitt's lymphoma is a particularly cruel disease, hitting mostly children and developing aggressively. (nih.gov)
This opens many doors for improved understanding and potential treatments of Burkitt's lymphoma. (nih.gov)
He noted that more effective treatments for Burkitt's lymphoma are needed especially in Africa. (nih.gov)
Lymphoblasts of two tissue culture strains (EB1 and EB2) from different biopsy specimens of Burkitt's lymphoma have been examined in thin sections by electron microscopy, and have each been found to carry a morphologically identical virus. (nih.gov)
Endemic Burkitt's lymphoma is the most frequent childhood cancer in Africa, commonly presenting with involvement of the abdominal viscera. (scielo.org.za)
Burkitt's lymphoma is one of the most common types of non-Hodgkin's lymphoma in childhood. (scielo.org.za)
[2] The World Health Organization classification stratifies Burkitt's lymphoma into endemic, sporadic and HIV-associated variants. (scielo.org.za)
Ultrasound-guided renal biopsy demonstrated a high-grade B-cell lymphoma, with morphological and immunophenotypic features consistent with a Burkitt's lymphoma. (scielo.org.za)
Endemic Burkitt's lymphoma classically presents with abdominal involvement, commonly bowel, nodal and secondary renal involvement. (scielo.org.za)
Burkitt's lymphoma has the highest incidence of renal involvement of the childhood lymphomas, usually in the terminal stage. (scielo.org.za)
Endemic Burkitt's lymphoma must be considered when a child presents with an abdominal mass in the African environment. (scielo.org.za)
This expedites treatment initiation, as Burkitt's lymphoma has a rapid tumour doubling time of less than 24 hours. (scielo.org.za)
A case of Burkitt's lymphoma in England. (springer.com)
Low-intensity therapy in adults with Burkitt's lymphoma. (springer.com)
Magrath IT, Lwanga S, Carswell W, Harrison N. Surgical reduction of tumour bulk in management of abdominal Burkitt's lymphoma. (springer.com)
Primary gastric Burkitt's lymphoma is a rare disease that belongs to the aggressive non-Hodgkin's lymphomas. (koreamed.org)
We report a case of primary gastric Burkitt's lymphoma in a 24-year-old female presenting with an intermittent epigastric pain for 3 months. (koreamed.org)
Burkitt's lymphoma: a child's case presenting in the maxilla. (biomedsearch.com)
Burkitt's lymphoma (BL) is a neoplasm which, despite its very aggressive behaviour is potentially curable. (biomedsearch.com)
Christopher Glass, communications officer for IMA World Health in New Windsor, is climbing Mount Kilimanjaro to raise money for Burkitt's lymphoma cancer awareness and research. (sun-sentinel.com)
His objective is to raise both awareness and funding to fight for Burkitt's lymphoma , a particularly aggressive form of childhood cancer for which IMA provides treatment in Tanzania and other Third World countries. (sun-sentinel.com)
Every dime he raises from sponsors and supporters will go toward treating kids with Burkitt's lymphoma. (sun-sentinel.com)
Burkitt's lymphoma (BL) is a rare malignancy arising from B-cells. (aacrjournals.org)
It has previously been reported that some salvage pathway enzymes are found on the surface of Burkitt's Lymphoma cells. (aacrjournals.org)
The potential surface presentation of HPRT was assessed using flow cytometry, scanning electron microscopy (SEM), and cytoplasmic staining on both healthy lymphocytes and Burkitt's Lymphoma cells (Raji). (aacrjournals.org)
These results suggest a direct relationship between HPRT and the surface of Burkitt's lymphoma cells, indicating HPRT as a potential target for future immunotherapeutic treatment in Burkitt's B-cell lymphoma pediatric patients. (aacrjournals.org)
Burkitt's lymphoma is a cancer of the lymph nodes which mostly affects children. (natural-homeremedies.com)
Not all Burkitt's lymphoma have viral origins. (natural-homeremedies.com)
If you are suffering from Burkitt's lymphoma then you should incorporate plenty of green leafy vegetables such as spinach, kale, Brussels sprouts and broccoli in your diet . (natural-homeremedies.com)
At this meeting I'll be talking about Burkitt's lymphoma, specifically I'll be talking about the EMBLEM study which is a study we designed to look at questions that were asked fifty years ago when Burkitt's lymphoma was discovered when malaria was hypothesised as a causal factor in Burkitt's lymphoma. (ecancer.org)
What we're doing in EMBLEM is a case control study where we get cases that have Burkitt's lymphoma and controls who are children who don't have Burkitt's lymphoma and then we are using a genomic approach because some people who have certain genotypes that protect them from malaria will have a lower burden of malaria in their lifetime. (ecancer.org)
So it will actually measure the relationship between malaria and Burkitt's lymphoma using this indirect approach. (ecancer.org)
So we'll be able to test our hypothesis that children who have genetic resistance to malaria will have a lower risk for Burkitt's lymphoma. (ecancer.org)
These include diagnosing cancer, especially Burkitt's lymphoma, so there has been an improvement in that area, we can tell you the number that we've diagnosed. (ecancer.org)
We've improved treatment of Burkitt's lymphoma, so provided protocol based treatments to the children who attend the hospitals which are participating with us and we are introducing what we call BL, Burkitt's lymphoma, community awareness campaigns. (ecancer.org)
These are simple, plain language posters that we can use to educate the community and health workers about Burkitt's lymphoma. (ecancer.org)
A little bit of history about Burkitt's lymphoma would be appropriate here. (ecancer.org)
In terms of diseases that we've discovered in the last fifty years, Burkitt's lymphoma was discovered in 1958, it has had a tremendous impact on science. (ecancer.org)
Burkitt's lymphoma (BL) cell lines carry a translocated c- myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. (aacrjournals.org)
The World Health Organisation classification reports three subcategories of Burkitt's lymphoma (BL)-endemic, non-endemic, and immunodeficiency associated-proposed to reflect the major clinical and genetic subtypes of this disease. (bmj.com)
1 In 1961, the neoplasm was identified as a form of malignant lymphoma, and what had initially emerged as a clinical syndrome became a pathological entity called Burkitt's lymphoma (BL). (bmj.com)
Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. (jimmunol.org)
Fresh biopsy cells from cases of Burkitt's lymphoma (BL) display a homogeneous cell surface phenotype. (jimmunol.org)
Burkitt's lymphoma rarely presents as a primary of the ovary. (ajol.info)
There are a few case reports presented on ovarian Burkitt's lymphoma. (ajol.info)
Autopsy, concluded the cause of death to be widely disseminated Burkitt's lymphoma, with a most likely tubo-ovarian primary and intestinal obstruction. (ajol.info)
Burkitt's lymphoma should be considered as a differential diagnosis in ovarian masses for timely diagnosis and management. (ajol.info)
The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. (thefreedictionary.com)
Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. (thefreedictionary.com)
Background Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. (haematologica.org)
Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma. (haematologica.org)
Design and Methods We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling. (haematologica.org)
Results Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. (haematologica.org)
Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. (haematologica.org)
Conclusions Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. (haematologica.org)
Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy. (haematologica.org)
Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma characterized by specific morphological and immunophenotypic features, a high proliferation rate (Ki-67 index exceeding 90%) and, on the molecular level, by a chromosomal translocation involving the MYC oncogene. (haematologica.org)
The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt's lymphoma. (ac.be)
This is a rare location of sporadic Burkitt's lymphoma with neurologic syndrome as first symptoms. (ac.be)
Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitt's lymphoma cell line by a monoclonal antibody against a 200,000 dalton EBV membrane antigen. (rupress.org)
Burkitt's lymphoma in the elderly. (ecancer.org)
Burkitt's lymphoma is a disease that can frequently be cured using intensive chemotherapy when found in younger patients. (ecancer.org)
Antonello Pinto from Naples, you are one of the steering committee on this and I know one of the things you're interested in is Burkitt's lymphoma. (ecancer.org)
The problem is that up to a few years ago, the idea that an elderly patient may develop Burkitt's lymphoma was not universally accepted. (ecancer.org)
The reality is that although Burkitt's lymphoma is a rare tumour, it is about 2% of Non-Hodgkin's lymphoma, about one third of patients developing the sporadic form, not the African form of Burkitt's lymphoma. (ecancer.org)
AP More or less some 31% to 32% of patients developing sporadic Burkitt's lymphoma in the western world - I mean, the States and Europe - are older than 65 years. (ecancer.org)
I mean, treatment of Burkitt's lymphoma in elderly adults is still a mathematical need because if you simply treat those patients by applying the same product that you use for young adolescents, you may have responses in some patients but there is a serious risk of losing the others because of toxicity. (ecancer.org)
Burkitt's lymphoma is not a preventable disease. (healthtap.com)
We studied a group of 54 children with Burkitt's lymphoma from Southeastern Brazil, where epidemiological status of Burkitt's lymphoma is poorly understood. (haematologica.org)
Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt's lymphoma risk, may characterize Burkitt's lymphoma in Brazil. (haematologica.org)
Burkitt's lymphoma (BL) shows marked variation across different geographical regions with respect to age-specific incidence, primary tumor site and association with Epstein-Barr virus (EBV) infection, 1 which characterize the endemic (eBL) and sporadic (sBL) subtypes. (haematologica.org)
Marked, transient inhibition of expression of the Epstein-Barr virus latent membrane protein gene in Burkitt's lymphoma cell lines by electroporation. (asm.org)
Burkitt's Lymphoma (BL) is a rare, aggressive and fast growing human tumor and was the first human tumor to be associated with an Epstein-Barr Virus (EBV) [ 1 ]. (omicsonline.org)
BACKGROUND: The Epstein-Barr virus (EBV) is associated with lymphoid malignancies, including Burkitt's lymphoma (BL), and can transform human B cells in vitro. (uzh.ch)
Adult Burkitt's lymphoma emerged as an AIDS-defining condition in the 1980s. (ajol.info)
We describe a case of HIV-associated adult Burkitt's lymphoma diagnosed and treated with high-dose chemotherapy in our institution, complicated by unusual bilateral renal vein tumour thrombi and tumour lysis syndrome. (ajol.info)
Multiple liver masses were detected and a biopsy revealed Burkitt's lymphoma. (biomedcentral.com)

The tumor cells have a similar appearance to the cancer cells of classical endemic Burkitt lymphoma. (wikipedia.org)
Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are supposed to possess identical IgH genes. (wikipedia.org)
The tumor cells in Burkitt lymphoma generally strongly express markers of B cell differentiation (CD20, CD22, CD19), as well as CD10 and BCL6. (wikipedia.org)
The lymphoma is in only one place, either as a single tumor not in lymph nodes, or in lymph nodes in one part of the body (the neck, groin, underarm, etc. (cancer.org)
The lymphoma is more than one tumor and/or in more than one set of lymph nodes, all of which are either above or below the diaphragm (the thin breathing muscle that separates the chest and abdomen). (cancer.org)
But other factors can also affect a child's outlook, such as the location and size of the tumor(s), and how well the lymphoma responds to treatment . (cancer.org)
Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. (hindawi.com)
The endemic variant of Burkitt lymphoma observed in equatorial Africa - a rapidly progressive jaw or orbital tumor - is the most common presentation, occurring more frequently in young children. (renalandurologynews.com)
The following chapter sheds light on epidemiology, tumor biology, treatment options and prognosis of this lymphoma which has evolved from an enigmatic syndrome to a curable disease. (springer.com)
A case of a so-called "Burkitt tumor" in a Dutch boy. (springer.com)
In the case of Burkitt's lymphomas (BL), most current evidence indicates that the tumor requires the virus minimally to block apoptosis. (pubmedcentralcanada.ca)
For both cervical carcinomas carrying human papillomaviruses (HPV) and Burkitt's lymphomas carrying Epstein-Barr virus (EBV), inhibiting viral genes in cell culture induces cell death in the tumor derived cells [ 8 - 10 ]. (pubmedcentralcanada.ca)
There are cases with poor outcome caused by toxic effects of the therapy, tumor lysis syndrome or metastatic spread of lymphomas to the central nervous system. (aacrjournals.org)
However, as lymphomas are known to form metastases in several sites, the analysis of their metastatic behavior and the suppression of this by imipramine-blue treatment may have implications for other aggressive tumor types as well. (aacrjournals.org)
Nevertheless, there are cases of poor clinical outcome caused by the toxicity of the intensive chemotherapy, tumor lysis syndrome, or metastatic spread of lymphoma cells to the central nervous system ( 4-7 ). (aacrjournals.org)
Here, we demonstrated for the first time the overexpression of DNMT1 and DNMT3B in Burkitt lymphoma (BL) tumor samples (69% and 86%, respectively). (sigmaaldrich.com)
The first broad genetic landscape map of a Burkitt lymphoma tumor has identified 70 mutations, including several not previously associated with cancer and a new one that is unique to the disease. (oncologynurseadvisor.com)
Dave explained that this alteration alone may not cause cancer, but when it occurs along with the MYC gene mutations that are common in Burkitt lymphoma and other malignancies, it works like an accelerant to fuel tumor growth. (oncologynurseadvisor.com)
Called also African lymphoma and Burkitt's tumor . (thefreedictionary.com)
The underlying mechanism of action of CDBPA in Burkitt`s lymphoma was tested in vitro and its effect on tumor size and survival was tested in a NOD-scid mice model. (omicsonline.org)

The epidemic variant of Burkitt lymphoma (eBL) is in almost all cases associated with EBV infection. (wikipedia.org)
[ 1 ] Burkitt-like lymphoma (BLL) is considered to be a morphologic variant of Burkitt lymphoma. (medscape.com)
A morphologic variant of Burkitt lymphoma characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages. (mycancergenome.org)

It is named after Denis Parsons Burkitt , a surgeon who first described the disease in 1958 while working in equatorial Africa . (wikipedia.org)
Named after Denis Parsons Burkitt, a surgeon who first described the disease in 1956. (yourdictionary.com)

An abstract of the study "Insertion of IGH into MYC in Burkitt Lymphoma identified by sequential FISH on paraffin sections" is presented. (ebscohost.com)
Mark J. Roschewski, MD , of the National Cancer Institute, discusses phase II study findings that showed DA-EPOCH-R cures most adult patients with Burkitt lymphoma, irrespective of HIV status (Abstract 188). (ascopost.com)

They also have some features of diffuse large B-cell lymphoma (DLBCL) cells. (cancer.ca)
The normal germinal centre B cell is the presumed cell of origin for both BL and diffuse large B-cell lymphoma (DLBCL), yet gene expression analysis suggests that these malignancies may use different oncogenic pathways. (nih.gov)
a, CCND3 mutations in BL, GCB DLBCL, ABC DLBCL and follicular lymphoma (FL) are shown with respect to amino acid positions 250-292 of protein accession NP_001751. (nih.gov)
Diffuse large B-cell lymphoma (DLBCL) is the most common NHL and may have a MYC rearrangement in 5% of cases. (renalandurologynews.com)
Given the relative incidence of DLBCL, Burkitt lymphoma occurs less commonly in developed countries than MYC+ DLBCL. (renalandurologynews.com)
Cases with morphologic features intermediate between DLBCL and Burkitt lymphoma are termed "B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma" as per the current World Health Organization classification. (renalandurologynews.com)
1 However, the characteristic immunophenotype of BL and MYC translocations can also be detected in a subset of diffuse large B-cell lymphomas (DLBCL) 2 making the distinction between these two entities sometimes problematic. (haematologica.org)
Based on the results of this study, investigators conclude that future studies are needed to determine how best to treat adult patients with Burkitt lymphoma and DLBCL who have involved CSF. (onclive.com)
These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. (wikipedia.org)
The most common types of high grade non-Hodgkin lymphoma are: Diffuse large B cell lymphoma (DLBCL) is a type of high-grade NHL which is the most common type of NHL worldwide at affecting 30-40 percent of all NHL cases. (wikipedia.org)
citation needed] For advanced diffuse large B cell lymphoma the standard therapy for patients with DLBCL is the combination use of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). (wikipedia.org)

While this type of lymphoma is still relatively rare in the United States , it is responsible for 50% of cancer deaths in children in Uganda and central Africa. (encyclopedia.com)
Endemic Burkitt lymphoma is also called African Burkitt lymphoma because it mainly occurs in Africa. (cancer.ca)
Endemic Burkitt lymphoma is seen among the young of equatorial Africa. (lymphomation.org)
Sporadic Burkitt lymphoma occurs throughout the world, and endemic Burkitt lymphoma occurs in Africa. (cancer.gov)
Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. (clinicaltrials.gov)
Epidemiology of Burkitt lymphoma in East African children and minors (EMBLEM) is a case-control study of 1500 BL cases and 3000 age-, sex- and residence-frequency matched controls we are proposing to conduct in East Africa. (clinicaltrials.gov)
Burkitt lymphoma is one of the most common childhood cancers in equatorial Africa. (globalgiving.org)
In 1958, Denis Burkitt reported the first cases of a "sarcoma" of the jaws in children from equatorial Africa, 1 discovering a disease which a few years later would be recognized as a very aggressive form of lymphoma, 2 universally known as Burkitt lymphoma (BL) ( Figure 1 ). (dovepress.com)
There is a low background incidence of BL worldwide (sBL), which is rarely associated with EBV and accounts for 1-2% of adult lymphoma in Western Europe and America, but eBL is associated with (EBV) in over 95% of cases and is predominant in the equatorial belt of Africa and other parts of the world where malaria is hyperendemic. (bmj.com)
a form of undifferentiated lymphoma , usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. (thefreedictionary.com)
Endemic Burkitt lymphoma is a form of cancer that accounts for up to 74% of malignant disorders in children in equatorial Africa. (bio-medicine.org)
Epstein-Barr virus (EBV) and malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. (uzh.ch)
Dr.Burkitt identified this disease in 1956 in children in Africa. (wikipedia.org)
In Africa, Burkitt lymphoma is common in children also infected by malaria and Epstein-Barr virus. (wikipedia.org)
Outside of Africa, Burkitt lymphoma is less common. (wikipedia.org)

The long-term survival rate is over 90% for limited stage (stage I and II) diffuse large B-cell lymphomas and is slightly lower for anaplastic large cell lymphomas. (cancer.org)
This study was the first complete sequence of a Burkitt lymphoma genome, plus genes from 59 additional Burkitt cases and 94 diffuse large B cell lymphomas, which share many of the same characteristics of Burkitt lymphoma. (oncologynurseadvisor.com)
Striking differences were found in the gene mutation pattern of Burkitt lymphomas compared with the diffuse large B cell lymphomas. (oncologynurseadvisor.com)
But if misdiagnosed and given the standard chemotherapy regimes for diffuse large B cell lymphomas, Burkitt lymphoma patients invariably relapse. (oncologynurseadvisor.com)
One of the newly identified gene mutations, ID3, appeared in 34% of the Burkitt cases, but was not evident in any of the diffuse large B cell lymphomas. (oncologynurseadvisor.com)

Sporadic Burkitt lymphoma is also called non-African, or non-endemic, Burkitt lymphoma. (cancer.ca)
Central nervous system involvement has been reported in up to one-third of patients, is typically associated with other sites of extranodal involvement, and appears more frequently in endemic Burkitt lymphoma. (renalandurologynews.com)
Termed endemic Burkitt lymphoma, the majority of cases are Epstein-Barr virus (EBV)-related. (renalandurologynews.com)
Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. (ajtmh.org)

This technique is useful since sometimes benign reactive processes (e.g. infectious mononucleosis) and malignant lymphoma can be difficult to distinguish. (wikipedia.org)
D. Burkitt and G. T. O'Conor, "Malignant lymphoma in African children. (hindawi.com)
Concepts about malignant lymphoma. (ebscohost.com)
Delpassand ES, Kirkpatrick JB (1988) Cavernous sinus syndrome as the presentation of malignant lymphoma. (springer.com)
a form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. (thefreedictionary.com)

Lactic acidosis is a rare complication of malignancies and is seen more frequently in high grade lymphoma and leukemia. (scirp.org)
Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma revealing one of the highest proliferation rates in malignancies. (springer.com)
We knew that Burkitt lymphoma is curable with dose-intensive chemotherapy, but that treatment can be acutely toxic for adult patients," lead study author Mark Roschewski, MD, senior clinician and clinical director of the Lymphoid Malignancies Branch at the National Cancer Institute, stated in a press release. (onclive.com)

Other lymphoma histologies, including lymphoblastic lymphoma and blastic mantle cell lymphoma, present in a similar fashion to sporadic Burkitt lymphoma in adults. (renalandurologynews.com)

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. (nih.gov)
Access details on the publication of Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics from PubMed. (nih.gov)
Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. (sigmaaldrich.com)

Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). (hu-berlin.de)
The reactivation of p16 and p14 in our model and our ability to inhibit cell proliferation and induce apoptosis through the Rb- and p-53 pathways opens new prospects for the understanding and treatment of Burkitt lymphoma. (oncologynurseadvisor.com)
Exposure to Sonic or Indian Hedgehog or cyclopamine (SMO inhibitor) does not modulate GLI1 expression, cell proliferation, or apoptosis in most Burkitt lymphoma cell lines. (luriechildrens.org)
Inhibition of GLI1 by GANT61 increases apoptosis and reduces viability of some Burkitt lymphoma cells. (luriechildrens.org)
Discovery of an Apoptosis Inducing Ligand for Burkitt Lymphoma" by Carolyn Laymon, Kyla Bradylong et al. (calpoly.edu)
We demonstrated that CDBPA significantly reduced cell viability and induced apoptosis via the extrinsic and the intrinsic apoptotic pathways of Burkitts lymphoma cells without causing cell cycle arrest but reduction of the various phases. (omicsonline.org)

The 'starry sky' appearance of Burkitt lymphoma characterized by benign macrophages interspersed amoung a diffuse infiltration of monotonous malignant lymphocytes. (renalandurologynews.com)
Findings from an ongoing, multicenter, phase 2 study identified an alternative treatment to dose intense chemotherapy through dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab for adults with untreated Burkitt lymphoma and diffuse large B-cell lymphoma. (onclive.com)
Diffuse large B-cell lymphoma is the most common subtype as well as the most common type of Non-Hodgkin Lymphoma. (wikipedia.org)

Currently, Burkitt lymphoma can be divided into three main clinical variants: the endemic, the sporadic , and the immunodeficiency -associated variants. (wikipedia.org)
What's the purpose of clinical trials for lymphoma drugs and treatments? (webmd.com)
Burkitt and Burkitt-like lymphomas have a rapid and aggressive clinical course with frequent bone marrow and central nervous system (CNS) involvement. (medscape.com)
2 While patients who present with intussusception as their first clinical sign are diagnosed earlier, this does not change the prognosis as patients with the sporadic form of Burkitt lymphoma have an excellent prognosis regardless of the staging of the disease. (appliedradiology.com)
Burkitt lymphoma (BL) is currently classified as one of three clinical variants: endemic BL, sporadic BL, and HIV-associated BL. (bcgsc.ca)
Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. (onmedica.com)
Clinical outcome of relapsed or refractory burkitt lymphoma and mature B-cell lymphoblastic leukemia in children and adolescents. (springer.com)
Carla Casulo, MD , of the James P. Wilmot Cancer Center, discusses findings on POD24 as a robust early clinical endpoint of poor survival in follicular lymphoma, using data from mor. (ascopost.com)
There is 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are completed or closed. (mycancergenome.org)
KMT2A, KMT2A-AFF1, and KMT2A-ELL are the most frequent gene inclusion criteria for atypical Burkitt/Burkitt-like lymphoma clinical trials [ 3 ]. (mycancergenome.org)
Nivolumab and varlilumab are the most common interventions in atypical Burkitt/Burkitt-like lymphoma clinical trials. (mycancergenome.org)
AFF1 is an inclusion eligibility criterion in 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are closed. (mycancergenome.org)
NRIP3 is an inclusion eligibility criterion in 1 clinical trial for atypical Burkitt/Burkitt-like lymphoma, of which 1 is open and 0 are closed. (mycancergenome.org)

J. Durig, W. Fiedler, M. de Wit, M. Steffen and D. Hossfeld, "Lactic Acidosis and Hypoglycemia in a Patient with High-Grade Non-Hodgkin's Lymphoma and Elevated Circulating TNF-a," Annals of Hematology, Vol. 72, No. 2, 1996, pp. 97-99. (scirp.org)

In a collaborative effort involving more than 16 institutions around the globe, researchers from the Simon Fraser University (SFU)'s Department of Molecular Biology and Biochemistry have refined the classification of a rare cancer called Burkitt lymphoma (BL). (sfu.ca)

The sporadic type of Burkitt lymphoma (also known as "non-African") is the most common variant found in places where malaria is not holoendemic . (wikipedia.org)
It is the most common type of Burkitt lymphoma in North American and European countries. (cancer.ca)

For the rarer cases of adults with Burkitt lymphoma, treatment-related toxicities remain a significant obstacle to treatment. (onclive.com)
Study confirms effective, less toxic alternative to standard treatment for adults with Burkitt lymphoma. (onclive.com)
A multi-center retrospective study of 557 newly diagnosed adults with Burkitt lymphoma over a 9-year period (2009-2018). (mdedge.com)

It often develops with chemotherapy for Burkitt lymphoma, so the healthcare team will take measures to prevent TLS before chemotherapy starts. (cancer.ca)
Ruth required supportive care, including nutritional support, and was started on first-line (FL) chemotherapy for Burkitt lymphoma that consisted of cyclophosphamide, vincristine, methotrexate and treatment to prevent the spread of disease to her central nervous system. (globalgiving.org)

All types of Burkitt lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations . (wikipedia.org)
Burkitt lymphoma, or small noncleaved cell lymphoma, is a highly aggressive B-cell non-Hodgkin lymphoma characterized by the translocation and deregulation of the c-myc gene on chromosome 8. (medscape.com)
Methylation of CpG islands in promoter gene regions is frequently observed in lymphomas. (sigmaaldrich.com)
That finding could prove helpful for developing a new drug to function like a normal ID3 gene and suppress cancer cell proliferation in lymphomas as well as numerous other cancers. (oncologynurseadvisor.com)
Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines. (asm.org)

No unusual local patterns of leukemia, lymphoma, or infectious mononucleosis incidence were found, and no other persons with childhood cancer were identified as having been in contact with the patients or being in their particular neighborhood. (cdc.gov)
In developed countries where sporadic cases are most commonly encountered, Burkitt lymphoma can occur at any age, although the peak incidence is in the first decade of life. (renalandurologynews.com)
Meningeal involvement in non-Hodgkin's lymphoma: symptoms, incidence, risk factors and treatment. (springer.com)
Burkitt lymphoma is a rare disease with an incidence rate of approximately 0.2, which means that 2 individuals within a population of 1 million are affected by Burkitt lymphoma per year ( 2 ). (aacrjournals.org)
Because of the low incidence of the disease, research on novel drugs for Burkitt lymphoma treatment proceeds only slowly. (aacrjournals.org)
Before highly active antiretroviral therapy (HAART) became a widespread treatment for HIV/AIDS, the incidence of Burkitt lymphoma was estimated to be 1,000 times higher in HIV-positive people than in the general population. (wikipedia.org)

[4] Non-Hodgkin lymphoma, which includes Burkitt's, accounts for 30-50% of childhood lymphoma. (wikipedia.org)
Childhood Non-Hodgkin Lymphoma Treatment. (cancer.org)
Kamdar KY, Sandlund JT, Bollard CM. Malignant lymphomas in childhood. (cancer.org)
Ceyhan M, Erdem G, Kanra G, et al (1994) Lymphoma with bilateral cavernous sinus involvement in early childhood. (springer.com)
Sporadic BL is the most common type (30-40%) of childhood non-Hodgkin lymphoma. (clinicaladvisor.com)
Letter: childhood lymphoma resembling Burkitt's tumour in the southern Argentine. (bmj.com)
AP We are very successful in treating and curing this lymphoma in childhood and young adolescence with very intensive chemotherapy regimes which are based on the rapid recycling of drugs and on a very aggressive CNS directed treatment, because this lymphoma typically involves the central nervous system. (ecancer.org)

In the United States , the non-Hodgkin's lymphomas as a group account for about 7% of cancers in persons under 20 years of age. (encyclopedia.com)
Epstein-Barr virus is associated with an increased risk of certain cancers, including Burkitt lymphoma. (cancer.ca)
But when it comes to children with non-Hodgkin lymphoma (NHL), those who are still alive and free of lymphoma after 5 years are very likely to have been cured, as it's rare for these cancers to return after this much time. (cancer.org)
DCEG researchers conduct studies and participate in consortial activities on cancers of the white blood cells, known as lymphomas. (cancer.gov)
These proteins are implicated in 70% of all cancers, including leukaemia and lymphoma. (leukaemia.org.au)
This project helps to improve survival rates through the training of doctors and nurses in the management of children, not only with Burkitt lymphoma, but with other cancers, too. (globalgiving.org)

The analysis identified 70 genes that were frequently mutated in the Burkitt lymphomas, including a number of genes that were identified in cancer for the first time. (oncologynurseadvisor.com)
To study the cell type specificity of the direction of replication of the human c-myc genes and the relationship of replication polarity to transcriptional activity, we analyzed the directions of replication of the c-myc genes in two Burkitt lymphoma cell lines, CA46 and ST486, and in HeLa cells. (asm.org)

Burkitt lymphoma is a cancer of the lymphatic system , particularly B lymphocytes found in the germinal center . (wikipedia.org)
Burkitt lymphoma is a form of non-Hodgkin's lymphoma in which cancer starts in immune cells called B-cells. (webmd.com)
If more than 25% of the bone marrow is made up of cancer cells, called blasts , the cancer is classified as acute lymphoblastic leukemia [ALL] instead of lymphoma. (cancer.org)
2016. Accessed at www.cancer.gov/types/lymphoma/hp/child-nhl-treatment-pdq on June 8, 2017. (cancer.org)
I work in the Blood Cells and Blood Cancer Division, headed by Professor Strasser, and we are trying to understand the control of the pathways to cell death with the objective of manipulating them specifically with therapeutics to make lymphoma cells die. (leukaemia.org.au)
If cancer cells are genetically engineered in the laboratory to remove the MCL-1 protein, the lymphoma cells die very rapidly. (leukaemia.org.au)
This finding identified MCL-1 as a therapeutic target for these particular lymphoma cells and now research is focusing on understanding the normal pathways that control cell death with the goal to manipulate this process to selectively kill cancer cells. (leukaemia.org.au)
The study was initiated by the Foundation for Burkitt Lymphoma Research based in Switzerland and funded in partnership with the National Cancer Institute (HHSN261200800001E) with salary support from the Terry Fox Research Institute. (sfu.ca)
Dr. Louis M. Staudt of the NIH's National Cancer Institute and his colleagues conducted genetic sequencing with high-capacity technology, which allowed them to quickly identify likely mutations that may cause the lymphoma. (nih.gov)
Read the article A Conversation with Dr. Louis Staudt about Targeting New Treatments for Burkitt Lymphoma from the September 4, 2012 issue of the National Cancer Institute Cancer Bulletin . (nih.gov)
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251. (springer.com)
Burkitt lymphoma is a fatal cancer if left untreated. (globalgiving.org)
The International Network for Cancer Treatment and Research (INCTR) has designed a simple treatment plan for Burkitt lymphoma that can be safely delivered in African hospitals. (globalgiving.org)
Dr Mbulaiteye discusses early findings from the EMBLEM study, which aims to analyse the connection between Burkitt lymphoma, the first cancer to be found to have a virus associated with it, and malaria. (ecancer.org)
High-grade B-cell lymphoma that contains genetic changes that indicate the patient has a high risk of continued cancer growth. (mskcc.org)
Burkitt lymphoma (BL) is a very fast-growing type of cancer . (nih.gov)

There are 3 subtypes of Burkitt lymphoma. (cancer.ca)
b, Frequencies of CCND3 mutations in different lymphoma subtypes. (nih.gov)
DCEG's portfolio includes studies of Burkitt lymphoma, Hodgkin lymphoma, and non-Hodgkin lymphoma and its subtypes. (cancer.gov)
An international consortial project to comprehensively evaluate the etiology of 11 non-Hodgkin lymphoma (NHL) subtypes, considering family and medical history, lifestyle and occupational risk factors, and inherited genetic susceptibility. (cancer.gov)
These differences between endemic and sporadic BL do not mean that each of these subtypes of lymphoma represents a perfectly homogeneous entity. (bmj.com)
citation needed] There are several subtypes of aggressive lymphoma. (wikipedia.org)

The high mitotic activity of Burkitt lymphoma is confirmed by nearly 100% of the cells staining positive for Ki67. (wikipedia.org)
As a result, blast cells don't mature properly, and these abnormal immature blood cells (called Burkitt lymphoma cells) are found in the circulating blood. (cancer.ca)
If more than 25% of the cells in the bone marrow are Burkitt lymphoma cells, doctors may classify it as acute lymphocytic leukemia (ALL), L3 or Burkitt-type leukemia. (cancer.ca)
When viewed under a microscope, Burkitt-like lymphoma cells look somewhat different from Burkitt lymphoma cells. (cancer.ca)
Tumour lysis syndrome (TLS) is a group of side effects that develops when a large number of lymphoma cells are killed in a short period of time. (cancer.ca)
CNS prophylaxis is used to try to prevent the lymphoma cells from entering the tissue covering the brain and spinal cord. (cancer.ca)
This finding identified MCL-1 as a therapeutic target for these particular lymphoma cells," said Dr Kelly. (leukaemia.org.au)
Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines. (sciencemag.org)
Immunohistochemical staining showed neoplastic cells consistent with Burkitt lymphoma. (appliedradiology.com)
In Burkitt lymphoma, nearly 100% of the cells stain positive for Ki-67. (renalandurologynews.com)
The nature of the unknown, unidentified virus in the cultured lymphoblasts from Burkitt's lymphomas is considered and its possible relationship to the cells discussed. (nih.gov)
When the bone marrow contains more than 25% malignant Burkitt cells, the definition of Burkitt leukemia is met, which can occur with or without lymphomatous involvement. (clinicaladvisor.com)
Imipramine-blue reduces the size of experimental Burkitt lymphoma significantly but does not affect the dissemination of BL2B95 cells, angiogenesis, and lymphangiogenesis. (aacrjournals.org)
Thereby, we concentrated on the non-Hodgkin lymphoma subtype Burkitt lymphoma, which arises from B cells. (aacrjournals.org)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
While this smear is more cellular than is ideal for optimum evaluation of morphology, it is still possible to recognize the characteristic morphology of the lymphoma cells present. (labce.com)
The Burkitt cells are as large or larger than the few neutrophils present and somewhat resemble other types of lymphoblasts. (labce.com)
Lymphoma cells may build up in the lymph nodes and other organs, causing swelling. (nih.gov)
We initiated studies in Burkitt lymphoma cells, which constitutively express c-MYC due to a chromosomal translocation, to determine whether Hedgehog or c-MYC regulates GLI1 expression. (luriechildrens.org)
The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt lymphoma cells. (luriechildrens.org)
Burkitt lymphoma cells do not seem to be Hedgehog responsive. (luriechildrens.org)

Adult non-Hodgkin lymphoma treatment (PDQ) - health professional version. (medlineplus.gov)
In children, most SNCLs are Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas. (lymphomation.org)
Adult Burkitt leukemia and lymphoma. (springer.com)
About one-half of all Burkitt lymphoma (BL) patients are younger than 40 years, and one-third belong to the adolescent and young adult (AYA) subset, defined by an age between 15 and 25-40 years, based on selection criteria used in different reports. (dovepress.com)
Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. (haematologica.org)
Outcomes for adult Burkitt lymphoma in a contemporary, large real-world analysis appear inferior to those of smaller published series. (mdedge.com)
Burkitt lymphoma is an aggressive B cell malignancy accounting for 1-2% of all adult lymphomas. (eur.nl)

Immunodeficiency-associated Burkitt lymphoma is usually associated with HIV infection [5] or occurs in the setting of post-transplant patients who are taking immunosuppressive drugs. (wikipedia.org)
Sporadic Burkitt lymphoma often involves the abdomen, and it spreads to the bone marrow in about 20% of patients. (lymphomation.org)
Immunodeficient Burkitt lymphoma affects patients with abnormal immune systems (e.g., patients with HIV). (lymphomation.org)
Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol. (lymphomation.org)
Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients. (cancer.gov)
Common findings and symptoms in patients with Burkitt lymphoma are summarized below. (medscape.com)
Patients with more than 25% bone marrow involvement are usually referred to as having Burkitt leukemia. (medscape.com)
The third form of Burkitt lymphoma occurs in patients who are immunocompromised. (appliedradiology.com)
While BL often responds well to treatment, for 15-20% of BL patients, chemotherapy either doesn't work well, they can't tolerate the aggressive treatment or the lymphoma relapses quickly after treatment. (leukaemia.org.au)
The purpose of this study is to learn more about how well a chemotherapy regime including rituximab works in treating patients with Burkitt or atypical Burkitt lymphoma. (clinicaltrials.gov)
Trends in survival of patients with Burkitt lymphoma/leukemia in the USA: an analysis of 3691 cases. (springer.com)
A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial). (springer.com)
Thus, there is the need to develop minimally toxic substances to treat patients with high-grade-non-Hodgkin lymphoma efficiently. (aacrjournals.org)
Patients must have Burkitt lymphoma/leukemia or high-grade B-cell lymphoma that has continued to grow or came back despite prior treatment. (mskcc.org)
Burkitt lymphoma (BL) is highly FDG-avid even though its usefulness in the management of these patients is still controversial. (ovid.com)
And the second point is that even though you succeed in treating properly elderly patients, the fraction of long survivors is lower and this is probably due to a different biology of disease when this type of lymphoma arises in a patient who is older than 65. (ecancer.org)
Determine the overall response rate (complete remission, complete remission undetermined, and partial remission) in HIV-negative or HIV-positive patients with newly diagnosed Burkitt's or Burkitt-like lymphoma treated with doxorubicin hydrochloride liposome and rituximab as part of the Magrath regimen. (knowcancer.com)
citation needed] AIDS-associated lymphoma Angioimmunoblastic lymphoma Central nervous system (CNS) lymphoma Mantle cell lymphoma (MCL) Some of the risk factors that increase the risk factor of aggressive lymphoma include: Immunosuppressive medication used for organ transplant patients or autoimmune diseases. (wikipedia.org)
While advanced high grade aggressive lymphoma patients receive similar treatments, the duration is extended. (wikipedia.org)

Sporadic Burkitt lymphoma (sBL) most often presents as abdominal tumors with bone marrow involvement. (medscape.com)
2 The vascular encasement in Burkitt lymphoma differs from encasement seen in other tumors such as neuroblastoma. (appliedradiology.com)
Burkitt lymphoma-one of the most aggressive tumors-may be treatable with agents that can stop cell proliferation and induce cell death by reactivating two key proteins. (oncologynurseadvisor.com)
Since the presentation of aggressive lymphoma are similar to that of other types of Non-Hodgkin lymphoma it is important analyze the tumors morphologically and run immunohistochemical tests to ensure correct diagnosis. (wikipedia.org)

The lymphoma is in the central nervous system (brain or spinal cord) and/or the bone marrow when it is first found. (cancer.org)
Burkitt lymphoma can affect the bone marrow so that it doesn't work normally. (cancer.ca)
Immunodeficiency-related Burkitt lymphoma cases usually as with nodal involvement with frequent bone marrow involvement. (medscape.com)
Bone marrow involvement is documented in roughly 20% of cases of sporadic Burkitt lymphoma and may be much less common in the endemic variant. (renalandurologynews.com)
If Burkitt leukemia is suspected, perform a bone marrow biopsy and place cores in transport medium. (clinicaladvisor.com)

To evaluate the response rates in adults with Burkitt/atypical Burkitt. (clinicaltrials.gov)
Of the trial that contains atypical Burkitt/Burkitt-like lymphoma as an inclusion criterion, 1 is phase 2 (1 open). (mycancergenome.org)
Of the trial that contains NRIP3 status and atypical Burkitt/Burkitt-like lymphoma as inclusion criteria, 1 is phase 2 (1 open) [ 3 ]. (mycancergenome.org)

The treatment and prognosis (outlook) for a child with non-Hodgkin lymphoma (NHL) depend, to a large extent, on the lymphoma's stage. (cancer.org)
Chemotherapy is the main treatment for Burkitt lymphoma. (cancer.ca)
A goal of initiating therapy within 48 hours of presentation has been proposed as optimal treatment for Burkitt lymphoma. (renalandurologynews.com)
Thanks to your generous donations to this project, poor children from rural villages have access to the necessary treatment for Burkitt lymphoma, including salvage therapy when needed, in order to provide them with the hope for long-lasting cure and the chance to fulfill their dreams. (globalgiving.org)
In this observational study, we compared real-world efficacy, toxicity, and costs of four frequently employed treatment strategies for Burkitt lymphoma: the Lymphome Malins B (LMB), the Berlin-Frankfurt-Münster (BFM), the HOVON, and the CODOX-M/IVAC regimens. (eur.nl)
We conclude that the four treatment protocols for Burkitt lymphoma yield nearly identical results with regards to efficacy and safety but differ in treatment duration and costs. (eur.nl)
For aggressive lymphoma, swift and specific treatment dependent upon correct diagnosis can be the difference between life and death for the patient. (wikipedia.org)
citation needed] For limited high grade lymphoma the typical treatment is chemotherapy and a targeted drug, followed by radiotherapy. (wikipedia.org)

Burkitt lymphoma is a type of mature B-cell non-Hodgkin lymphoma (NHL). (cancer.ca)
Burkitt lymphoma is commonly associated with the infection of B cell lymphocytes with the Epstein-Barr virus (EBV) and in these cases in considered to be one form of the Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
B-cell lymphomas arise at distinct stages of cellular development and maturation, potentially influencing antigen (Ag) presentation and T-cell recognition. (hindawi.com)
From OncologyChannel: 'Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. (lymphomation.org)
FACS analysis of lymphoma cell lines transduced with mutant or wild type GFP-CCND3 fusion proteins. (nih.gov)
Burkitt Lymphoma is the fastest-growing type of B-cell non-Hodgkin lymphoma. (alexslemonade.org)
An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. (cancer.gov)
Biopsy findings were consistent with small noncleaved cell non-Hodgkin lymphoma. (medscape.com)
A lot of our work has been in cell lines established from these Burkitt's lymphomas. (leukaemia.org.au)
The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. (sciencemag.org)
At histology, Burkitt lymphoma has a classic "starry sky" appearance due to rapid cell proliferation and spontaneous cell death. (appliedradiology.com)
The Epstein-Barr virus genome carried in the Burkitt lymphoma nonproducer cell line Raji was characterized by partial denaturation mapping and by hybridization of cloned viral fragments to filters containing separated Raji DNA fragments. (nih.gov)
Burkitt Lymphoma (BL) is a fast growing malignancy of B cell origin typically associated with a rapid onset and progression of symptoms. (clinicaladvisor.com)
CNS involvement in small noncleaved-cell lymphoma: is CNS disease per se a poor prognostic sign? (springer.com)
Outcome of and prognostic factors for relapse in children and adolescents with mature B-cell lymphoma and leukemia treated in three consecutive prospective "Lymphomes Malins B" protocols. (springer.com)
Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen. (springer.com)
Burkitt Lymphoma is one of the rare types of B-cell non-Hodgkin's lymphoma. (marketresearch.com)
The aim of this study is to investigate the potential of Hypoxanthine phosphoribosyltransferase (HPRT) as a surface biomarker and target for future immunotherapies in Burkitt's B-cell Lymphoma. (aacrjournals.org)
HPRT presence on the surface of this B-cell lymphoma subtype could provide a target for adoptive cell transfer and other immunotherapies. (aacrjournals.org)
Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
Since in Burkitt lymphoma these two proteins [INK4a and ARF] are not inactivated at the genetic level, their inactivation could be pharmacologically reversible," explained lead author Annalisa Roberti in a statement describing her group's findings, which were reported in the journal Cell Cycle (2011;10[1]:127-134). (oncologynurseadvisor.com)
It is a form of B- cell non-Hodgkin's lymphoma . (nih.gov)
We show that all Burkitt lymphoma cell lines tested express GLI1, PTCH1, and SMO and that five of six Burkitt lymphomas express GLI1. (luriechildrens.org)
The Raji, EB1, and EB2 cell lines are derived from Epstein-Barr virus (EBV)-positive Burkitt's lymphomas. (asm.org)
2016) An Innovative Cisplatin Diammine II Benzene-Poly- Carboxylic Acid Complex Inhibits Growth of Burkitt`S Cell Lymphoma In Vitro and In Vivo. (omicsonline.org)
Peripheral T-cell lymphomas are less common accounting for approximately 7% of all non-Hodgkin lymphoma cases. (wikipedia.org)

In 1958, Dennis Burkitt first described a disorder associated with jaw tumours in African children. (bmj.com)

An aggressive Burkitt lymphoma which affects adults and arises in a follicular lymphoma. (thefreedictionary.com)

Aggressive lymphoma, also known as high-grade lymphoma, is a group of fast growing Non-Hodgkin Lymphoma. (wikipedia.org)

Sporadic lymphomas are rarely associated with the Epstein-Barr virus. (wikipedia.org)

FISH analysis was indicative of a MYC oncogene rearrangement, commonly associated with Burkitt lymphoma. (appliedradiology.com)
Burkitt lymphoma commonly involves extranodal sites, usually when bulky disease is present. (appliedradiology.com)
In western countries where sporadic Burkitt lymphoma occurs more commonly, this presentation is relatively rare. (renalandurologynews.com)

So it was welcome news that an international team of scientists has unveiled some of the cancer's genetic secrets, making this form of non-Hodgkin's lymphoma easier to treat. (nih.gov)
Such a possibility has been spawned by a recent discovery regarding a genetic locus that has an important role in Burkitt lymphoma. (oncologynurseadvisor.com)

The differential diagnosis is vast, as lymphoma can affect almost any organ. (scielo.org.za)

If Burkitt lymphoma is suspected, all or part of an enlarged lymph node or other suspicious disease site will be biopsied. (webmd.com)
Stage I and II lymphomas are usually considered limited-stage disease and are treated the same way. (cancer.org)
Stage III and IV lymphomas are usually thought of as advanced-stage disease and are also treated alike. (cancer.org)
The fact that some Burkitt lymphoma cases do not involve EBV allows that many cases of the disease are not caused and/or promoted by EBV, i.e. the virus may be an innocent passenger virus in these cases. (wikipedia.org)
Multimodality imaging of Hodgkin disease and non-Hodgkin lymphoma in children. (scielo.org.za)
At present, though it is a highly malignant disease with demonstrated propensity to rapid growth and dissemination, provided it is correctly identified and treated, BL is the aggressive lymphoma subset associated with the highest cure rate in both adults and children. (dovepress.com)

Pediatric Hodgkin and non-Hodgkin lymphomas. (cancer.org)
As such, Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults. (renalandurologynews.com)
Pediatric Burkitt lymphoma has historically been treated with intensive methotrexate-based chemotherapy, which improves patient survival while causing severe toxicities. (ovid.com)

Burkitt lymphoma is an aggressive form of lymphoma. (oncologynurseadvisor.com)

Immunodeficiency-associated Burkitt lymphoma may demonstrate more plasmacytic appearance or more pleomorphism, but these features are not specific. (wikipedia.org)
Immunodeficiency-associated Burkitt lymphoma tends to occur in people with weakened immune systems, typically those with HIV infection. (cancer.ca)
The number of cases of immunodeficiency-associated Burkitt lymphoma seems to be dropping because antiretroviral therapy is used to treat HIV. (cancer.ca)
There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). (cancer.gov)

Anatomy13

Organisms2

Diseases24

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes22

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care2

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)

Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)

Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)

Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)

Burkitt Lymphoma

Lymphoma

Lymphoma, B-Cell

Lymphoma, Non-Hodgkin

Lymphoma, Large B-Cell, Diffuse

Lymphoma, T-Cell

Herpesvirus 4, Human

Lymphoma, Follicular

Lymphoma, AIDS-Related

Translocation, Genetic

Chromosomes, Human, 6-12 and X

Lymphoma, B-Cell, Marginal Zone

Epstein-Barr Virus Nuclear Antigens

Chromosomes, Human, 13-15

Glutamate Formimidoyltransferase

Genes, myc

Proto-Oncogene Proteins c-myc

B-Lymphocytes

Epstein-Barr Virus Infections

Lymphoma, Mantle-Cell

Lymphoma, T-Cell, Cutaneous

Hodgkin Disease

Lymphoma, T-Cell, Peripheral

Lymphoma, Large-Cell, Anaplastic

Chromosomes, Human, Pair 14

Vincristine

Tumor Cells, Cultured

Germinal Center

Oncogenes

Antibodies, Monoclonal, Murine-Derived

Cyclophosphamide

In Situ Hybridization, Fluorescence

Antigens, CD20

Chromosomes, Human, 1-3

Genes, Immunoglobulin Heavy Chain

Cell Line, Tumor

Immunophenotyping

Immunoglobulin Heavy Chains

Cell Line

Sesquiterpenes, Guaiane

Leukemia, B-Cell

Doxorubicin

Gene Rearrangement

Sesquiterpenes, Eudesmane

Chromosomes, Human, Pair 8

Neprilysin

Cytogenetics

Antineoplastic Combined Chemotherapy Protocols

Lymphoma, Large-Cell, Immunoblastic

Viral Matrix Proteins

HLA-A11 Antigen

Genes, myb

Immunohistochemistry

Gene Expression Regulation, Neoplastic

Proto-Oncogene Proteins c-bcl-2

Genes, bcl-2

Plasmacytoma

Cytarabine

Base Sequence

Apoptosis

Antibodies, Monoclonal

Tanacetum parthenium

Flow Cytometry

Virus Latency

Antigens, Viral

Prednisone

Inhibitor of Differentiation Proteins

Lymphoproliferative Disorders

DNA, Neoplasm

Genes, Immunoglobulin

Chromosome Banding

Karyotyping

Treatment Outcome

Methotrexate

Receptors, Antigen, B-Cell

Cell Transformation, Viral

Neoplasm Proteins

Antineoplastic Agents

Etoposide

Molecular Sequence Data