Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.Lymphoma, T-Cell: A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Lymphoma, Follicular: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.Lymphoma, AIDS-Related: B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Chromosomes, Human, 6-12 and X: The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Epstein-Barr Virus Nuclear Antigens: Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.Chromosomes, Human, 13-15: The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.Glutamate Formimidoyltransferase: A PYRIDOXAL PHOSPHATE-containing enzyme that catalyzes the transfer of a formyl group from L-GLUTAMATE to N-formimidoyl-L-glutamate and TETRAHYDROFOLATE. This enzyme may also catalyze formyl transfer from 5-formyltetrahydrofolate to L-GLUTAMATE. This enzyme was formerly categorized as EC 2.1.2.6.Genes, myc: Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.Proto-Oncogene Proteins c-myc: Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).Lymphoma, T-Cell, Cutaneous: A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Lymphoma, T-Cell, Peripheral: A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.Lymphoma, Large-Cell, Anaplastic: A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.Chromosomes, Human, Pair 14: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Germinal Center: The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.Oncogenes: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Antigens, CD20: Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.Chromosomes, Human, 1-3: The large, metacentric human chromosomes, called group A in the human chromosome classification. This group consists of chromosome pairs 1, 2, and 3.Genes, Immunoglobulin Heavy Chain: Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).Cell Line, Tumor: A cell line derived from cultured tumor cells.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Immunoglobulin Heavy Chains: The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Sesquiterpenes, Guaiane: SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.Leukemia, B-Cell: A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Gene Rearrangement: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.Sesquiterpenes, Eudesmane: SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.Chromosomes, Human, Pair 8: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Neprilysin: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.Cytogenetics: A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Lymphoma, Large-Cell, Immunoblastic: Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.HLA-A11 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.Genes, myb: Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.Plasmacytoma: Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Tanacetum parthenium: An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Virus Latency: The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Inhibitor of Differentiation Proteins: Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.DNA, Neoplasm: DNA present in neoplastic tissue.Genes, Immunoglobulin: Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).Chromosome Banding: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.Karyotyping: Mapping of the KARYOTYPE of a cell.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Receptors, Antigen, B-Cell: IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proto-Oncogenes: Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.Leukemia, Lymphoid: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Lymphoma, Extranodal NK-T-Cell: An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cell Line, Transformed: Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Chaperonin Containing TCP-1: A group II chaperonin found in eukaryotic CYTOSOL. It is comprised of eight subunits with each subunit encoded by a separate gene. This chaperonin is named after one of its subunits which is a T-COMPLEX REGION-encoded polypeptide.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Hybrid Cells: Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)

Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL) cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other EBV-positive BL cells express a restricted set of EBV gene products (type I latency) that are not known to overtly affect cell growth. Here we demonstrate that reestablishment of type I latency in EBV-negative Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resistance to apoptosis under growth-limiting conditions. The antiapoptotic effect of EBV was associated with a higher level of Bcl-2 expression and an EBV-dependent decrease in steady-state levels of c-MYC protein. Although the EBV EBNA-1 protein is expressed in all EBV-associated tumors and is reported to have oncogenic potential, enforced expression of EBNA-1 alone in EBV-negative Akata cells failed to restore tumorigenicity or EBV-dependent down-regulation of c-MYC. These data provide direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a novel model whereby a restricted latency program of EBV promotes B-cell survival, and thus virus persistence within an immune host, by selectively targeting the expression of c-MYC.  (+info)

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)

CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.  (+info)

Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)

Bruton's tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B cells is still unclear. This study represents a search for the substrate for Btk in vivo. We identified one of the major phosphoproteins associated with Btk in the preB cell line NALM6 as the Wiskott-Aldrich syndrome protein (WASP), the gene product responsible for Wiskott-Aldrich syndrome, which is another hereditary immunodeficiency with distinct abnormalities in hematopoietic cells. We demonstrated that WASP was transiently tyrosine-phosphorylated after B-cell antigen receptor cross-linking on B cells, suggesting that WASP is located downstream of cytoplasmic tyrosine kinases. An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk. A protein binding assay suggested that the tyrosine-phosphorylation of WASP alters the association between WASP and a cellular protein. Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown.  (+info)

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)

In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-crossblocking pairs), polyclonal anti-mu Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fab', F(ab')2 and F(ab')3 derivatives from anti-Fc mu mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (C mu2-C mu4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-Fd mu, or C mu1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb.  (+info)

Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)

Ligation of CD40 on the surface of B cells induces multiple phenotypic effects, many of which are mimicked by the EBV latent membrane protein 1 (LMP1) through its interaction with downstream components of the CD40 signaling pathway. Because the effects of LMP1 have been most closely studied in human Burkitt Lymphoma (BL) cell lines retaining a tumor biopsy-like phenotype in vitro, we have examined the response of a panel of such lines to CD40 ligation. Two distinct patterns of response were observed that were unrelated to the surface level of CD40 or to the EBV genome status of the lines. Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition. Aggregation was seen at lower doses than those required to elicit the other effects. By contrast, low responder (LR) lines showed no detectable response to CD40 mAbs, while their responses to sCD40L were limited to activation of NF-kappa B and up-regulation of CD95 only. However, in transfection experiments, LMP1 uniformly induced the full spectrum of phenotypic effects in both HR and LR lines. We conclude that some BL cell lines show a highly restricted response to CD40 ligation but remain fully susceptible to LMP1.  (+info)

Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)

Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans.  (+info)

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)

The consistent presence of EBV genomes in certain tumor types (in particular, AIDS-related central nervous system lymphomas and nasopharyngeal carcinomas) may allow novel, EBV-based targeting strategies. Tumors contain the latent (transforming) form of EBV infection. However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce lytic EBV infection, resulting in death of the host cell. We have constructed replication-deficient adenovirus vectors expressing the BZLF1 or BRLF1 immediate-early genes and examined their utility for killing latently infected lymphoma cells in vitro and in vivo. We show that both the BZLF1 and BRLF1 vectors efficiently induce lytic EBV infection in Jijoye cells (an EBV-positive Burkitt lymphoma cell line). Furthermore, lytic EBV infection converts the antiviral drug, ganciclovir (GCV), into a toxic (phosphorylated) form, which inhibits cellular as well as viral DNA polymerase. When Jijoye cells are infected with the BZLF1 or BRLF1 adenovirus vectors in the presence of GCV, viral reactivation is induced, but virus replication is inhibited (thus preventing the release of infectious EBV particles); yet cells are still efficiently killed. Finally, we demonstrate that the BZLF1 and BRLF1 adenovirus vectors induce lytic EBV infection when they are directly inoculated into Jijoye cell tumors grown in severe combined immunodeficiency mice. These results suggest that induction of lytic EBV infection in tumors, in combination with GCV, may be an effective strategy for treating EBV-associated malignancies.  (+info)

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)

In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene becomes transcriptionally activated as a consequence of the chromosomal translocation and shows preferential usage of promoter P1 over P2, a phenomenon referred to as promoter shift. In order to define the responsible regulatory elements within the Ig lambda locus, we studied the effect of the human Ig lambda enhancer (HuE lambda) on c-myc expression after stable transfection into BL cells. A 12 kb genomic fragment encompassing HuE lambda, but not HuE lambda alone, strongly activated c-myc expression and induced the promoter shift. To identify additional elements involved in c-myc deregulation, we mapped DNaseI hypersensitive sites within the 12 kb lambda fragment on the construct. Besides one hypersensitive site corresponding to HuE lambda, three additional sites were detected. Two of these elements displayed enhancer activity after transient transfection. The third element did not activate c-myc transcription, but was required for full c-myc activation and promoter shift. Deletion analyses of the c-myc promoter identified the immediate promoter region as sufficient for activation by the Ig lambda. locus, but also revealed that induction of the promoter shift requires additional upstream elements.  (+info)

*Burkitt's lymphoma

Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Non-Hodgkin lymphoma, which includes Burkitt's, accounts for 30-50% of childhood lymphoma. The jaw is less commonly involved, ... "NIH study shows Burkitt lymphoma is molecularly distinct from other lymphomas". National Cancer Institute. Staudt L; et al. ( ... The tumor cells have a similar appearance to the cancer cells of classical endemic Burkitt lymphoma. Sporadic lymphomas are ...

*Epstein-Barr virus infection

... causing excessive proliferation observed as Burkitt's lymphoma. Burkitt's lymphoma commonly affects the jaw bone, forming a ... Burkitt's lymphoma is a type of Non-Hodgkin's lymphoma and is most common in equatorial Africa and is co-existent with the ... Nasopharyngeal cancer Several Non-Hodgkin's lymphomas, including Burkitt's lymphoma and primary cerebral lymphoma Post- ... A late event in a very few carriers of this virus is the emergence of Burkitt's lymphoma and nasopharyngeal carcinoma, two rare ...

*List of OMIM disorder codes

MAOA Burkitt lymphoma; 113970; MYC Buschke-Ollendorff syndrome; 166700; LEMD3 C syndrome; 211750; CD96 C5 deficiency; 609536; ... FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; SIX3 ...

*Bozoma Saint John

Burkitt's Lymphoma Society. 2013. "Bozoma A Saintjohn United States Public Records". FamilySearch. 2008. Aswad, Jem (6 June ...

*Alexander John Haddow

Burkitt, D. P. (1971). "Epidemiology of Burkitt's Lymphoma". Proceedings of the Royal Society of Medicine. 64: 909-910. Silver ... Other notable work included relating the incidence of Burkitt's lymphoma to climatic conditions and the discovery of several ... Haddow's most prominent work was considered to be that on yellow fever and Burkitt's lymphoma. The Zika virus has since emerged ...

*Azzopardi phenomenon

Peng SL, Cheng CN, Chang KC (2007). "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682-3. doi: ...

*Raji cell

This suspension cell is derived from B-lymphocyte of an 11-year-old Nigerian Burkitt's lymphoma male patient in 1963. R.J.V. ... B Fadeel (30 September 2004 2005). "Raji revisited: cytogenetics of the original Burkitt's lymphoma cell line" (PDF). Leukemia ... A cell of a cultured line of lymphoblastoid cells derived from a Burkitt lymphoma; it possesses numerous receptors for a ... Burkitt's lymphoma -Growth Mode --> Suspension -Karotype --> 2n=46, diploid -Morphology --> Lymphoblastoid -Research Areas --> ...

*Epstein-Barr virus stable intronic-sequence RNAs

Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma). Especially interesting are the roles of non-coding RNAs ... of endemic Burkitt's lymphoma. Splicing of these W repeat transcripts produces a short intron and a long intron (Fig. 1), both ... "An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt ...

*Lymphoma

Paradoxically, high-grade lymphomas are more readily treated and have better prognoses:[citation needed] Burkitt lymphoma, for ... Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma ... Hodgkin lymphoma Classical Hodgkin lymphomas: Nodular sclerosis form of Hodgkin lymphoma Most common type of Hodgkin lymphoma ... large B-cell lymphoma ALK+ large B-cell lymphoma Plasmablastic lymphoma Primary effusion lymphoma Large B-cell lymphoma arising ...

*Bert Achong

Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt's lymphoma samples by ... Epstein, M.A; Achong, B.G; Barr, Y.M (1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". The Lancet. ... Epstein, Anthony (2012-03-01). "Burkitt lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology. 156 ... "Morphological and Biological Studies on a Virus in Cultured Lymphoblasts from Burkitt's Lymphoma". Journal of Experimental ...

*QSER1

Overexpression of QSER1 was noted in Burkitt's Lymphoma. QSER1 expression also increases with increasing Gleason score (more ... Altered expression of QSER1 is noted in pathological cardiomyopathy, Burkitt's Lymphoma, prostate cancer, and some breast ...

*Oncovirus

1964: Anthony Epstein, Bert Achong and Yvonne Barr identify the first human oncovirus from Burkitt lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... Carcinogen Oncogenic Oncogene Adult T-cell leukemia/lymphoma Cancer bacteria Oncolytic virus, a virus that infects and kills ...

*Epstein-Barr virus

EBV has been implicated in several diseases, including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's lymphoma, ... such as Hodgkin's lymphoma, Burkitt's lymphoma, gastric cancer, nasopharyngeal carcinoma, and conditions associated with human ... Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma". The ... "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and Cancer. 9 ( ...

*Idiopathic CD4+ lymphocytopenia

... primary leptomeningeal lymphoma, diffuse large cell lymphoma, MALT lymphoma, and Burkitt's lymphoma, among others. ICL may ... Shimano S, Murata N, Tsuchiya J (July 1997). "[Idiopathic CD4+ T-lymphocytopenia terminating in Burkitt's lymphoma]". Rinsho ... Campbell JK, Prince HM, Juneja SK, Seymour JF, Slavin M (April 2001). "Diffuse large cell lymphoma and t(8;22) (q24;q11) in a ... Lymphoma. 41 (3-4): 421-3. doi:10.3109/10428190109057998. PMID 11378556. Longo F, Hébuterne X, Michiels JF, Maniere A, Caroli- ...

*History of virology

He was the first to describe a type of cancer that now bears his name Burkitt's lymphoma. This type of cancer was endemic in ... Magrath I (September 2009). "Lessons from clinical trials in African Burkitt lymphoma". Current Opinion in Oncology. 21 (5): ... Bornkamm GW (April 2009). "Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more questions than answers". ... In an attempt to find a cause for the cancer, Burkitt sent cells from the tumour to Anthony Epstein (b. 1921) a British ...

*Michael A. Epstein

Epstein was the first person to propose that Burkitt's Lymphoma was a cancer caused by a virus. Upon hearing a lecture given by ... Epstein, A. (2012). "Burkitt Lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology (156): 777-779. ... changed his research focus from cancer causing viruses in chickens to searching for a viral origin of Burkitt's Lymphoma. After ... more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from them ...

*1964 in science

Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964-03-28). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma" ( ...

*Sid Couchey

In February 2012, Couchey was diagnosed with Burkitt's lymphoma. The aggressive cancer took hold quickly, and Couchey died on ...

*Denis Parsons Burkitt

Burkitt, together with Dr. Dennis Wright, published a book titled Burkitt's Lymphoma in April 1970. His second major ... ISBN 0-521-60633-0. p. 257 Denis P. Burkitt, "Discovering Burkitt's Lymphoma" in Paul H. Levine, Epstein-Barr Virus and Human ... Burkitt's lymphoma. Burkitt in 1957 observed a child with swellings in the angles of the jaw. "About two weeks later ... I ... The newly identified cancer became known as "Burkitt's lymphoma". He went on to map the geographical distribution of the tumour ...

*Myc

... gene was first discovered in Burkitt lymphoma patients. In Burkitt lymphoma, cancer cells show chromosomal translocations, ... A common human translocation involving Myc is critical to the development of most cases of Burkitt lymphoma. Malfunctions in ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...

*Eva Klein

In the 1960s, Eva Klein developed cell lines from Burkitt Lymphoma that continue to be used. In the 1970s, the Kleins' research ... Burkitt's lymphoma". In 2005, the year of the Kleins' 80th birthdays, scientists at the Karolinska Institute established the ... studying the role of the Epstein-Barr Virus in Burkitt Lymphoma. Klein became a member of the Royal Swedish Academy of Sciences ... is a Hungarian-Swedish scientist best known for leading the discovery of natural killer cells and developing Burkitt Lymphoma ...

*MiR-155

Zhang T, Nie K, Tam W (Sep 2008). "BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells". Leukemia. 22 (9): ... "Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma". Genes, Chromosomes & Cancer. 45 (2): 147-53 ... "High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma". Genes, Chromosomes & Cancer. 39 (2): 167- ... Over-expression of miR-155 leads to B cell lymphomas in mice (reviewed in ). It has been demonstrated that miR-155 can be ...

*UWA-101

... but had potent anti-cancer effects against Burkitt's lymphoma cells in vitro. UWA-121 is the (R)-enantiomer of UWA-101 and the ... nonpsychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity". Med. Chem. Comm. 1: 287-293. doi:10.1039/c0md00108b ... "Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative chemical redesign: ...

*DNA

"A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells". Proceedings of the National Academy of ...

*Lymphocryptovirus

Burkitt's lymphoma, and nasopharyngeal carcinoma. Group: dsDNA Order: Herpesvirales Family: Herpesviridae Sub-Family: ...

*Cervical cancer

Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, ... villoglandular adenocarcinoma Noncarcinoma malignancies which can rarely occur in the cervix include melanoma and lymphoma. The ...
What is Burkitt Lymphoma?. Burkitt lymphoma is a form of non-Hodgkins lymphoma which is a type of cancer that starts in the b-cells. Burkitt lymphoma is one of the fastest growing tumors. Burkitt lymphoma attacks the immune system and is fatal if not treated in a timely manner. There are three types of Burkitts lymphoma endemic, sporadic, and immunodeficiency- associated.. What causes Burkitt lymphoma? Who is affected?. The exact cause of Burkitt lymphoma is unknown, but there are factors associated with the disease such as Epstein-Barr. Individuals who are immunosuppressed have a higher risk factor for Burkitt lymphoma. Burkitt lymphoma primarily affects African children, and malaria may make children more vulnerable.. What are the symptoms of Burkitt lymphoma?. There are many symptoms associated with Burkitt lymphoma, including:. ...
An eight year old English boy presented with an abdominal undifferentiated Burkitt-like lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African endemic Burkitts lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was ...
Burkitt lymphoma (BL) (or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, was used to describe this disease in patients presenting with a soli...
Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells. Using more sensitive and specific transcriptome deep sequencing, we compared previously published small miRNA and long mRNA of a set of GC B cells and eBL tumors. MiRWalk2.0 was used to identify the validated target genes for the deregulated miRNAs, which would be important for understanding the regulatory networks associated with eBL development. We found 211 differentially expressed
Burkitt are highly aggressive lymphomas. As such, the goal of treatment is usually to cure the disease with aggressive therapy. From OncologyChannel: Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas. Burkitts lymphoma tends to occur most often in children and in adults with compromised immune systems. There are three distinct forms of this disease: endemic, sporadic, and immunodeficient.. ...
Buy our Raji (human Burkitts lymphoma cell line) membrane lysate, tumor cell line. ab30126 has been validated in western blot. Abcam now offers…
Buy our Raji (human Burkitts lymphoma cell line) whole cell lysate, tumor cell line. ab30124 has been validated in western blot. Abcam now offers…
Our laboratory is studying how antibody-forming cells respond to antigen by undergoing somatic hypermutation and class switch recombination so that they can produce higher affinity antibodies with more useful effector functions. The molecular and biochemical mechanisms of antibody variable region hypermutation and class switch recombination is being studied in mice that have mutations in various repair proteins in collaboration with Dr. Winfried Edelmann. In order to examine detailed molecular mechanisms, we are also studying how mutation is targeted to antibody genes and some oncogenes in human Burkitts lymphoma cell lines which are undergoing variable region mutation in culture. These cell lines and genetically defective mice are being used to study the role of activation induced deaminase (AID), mismatch repair and error prone polymerases in the variable region hypermutation and isotype switching. The analysis of these events also involves the examination of AID activity biochemically and, ...
The nuclear enzyme poly(ADP-ribose) polymerase (PADPRP) is thought to play a role in DNA recombination, replication, and repair. In view of the implication of these processes in tumorigenesis, and based on preliminary evidence which indicated the presence of an extraneous polymorphic restriction fragment for murine PADPRP loci in strains of mice susceptible to plasmacytomas, we investigated correlations between the restriction fragment length polymorphism of the PADPRP gene(s) and human Burkitt lymphoma. No increase in the frequency of polymorphisms on chromosome 1 (containing the active gene) or on chromosome 14 (a pseudogene) was observed. However, restriction fragment length polymorphism analysis of PADPRP sequences on chromosome 13 (either a processed pseudogene or a gene with extensive identity to PADPRP) revealed that of 19 DNA samples derived from endemic Burkitt lymphoma all contained at least one copy of a rare allele (B). Simple two-allele (A/B) polymorphisms in this PADPRP-like locus ...
Mouse monoclonal antibody raised against native CD19. Native purified CD19 from Daudi human Burkitt lymphoma cell line. (MAB4370) - Products - Abnova
Burkitts lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitts lymphoma is poor. Here we sought to identify a role of histone deacetylase 6 (HDAC6) in the metastasis of Burkitts lymphoma cells. Burkitts lymphoma cells were pharmacologically treated with niltubacin, tubacin or sodium butyrate (NaB) or transfected with siRNAs to knock down the expression of HDAC6. Cell migration and invasion ability were measured by transwell assay, and cell cycle progression was analyzed by flow cytometry. Cell adhesion and proliferation was determined by CellTiter-Glo luminescent cell viability assay kit. Cell morphological alteration and microtubule stability were analyzed by immunofluorescence staining. Effect of niltubacin, tubacin and NaB on acetylated tubulin and siRNA efficacy were measured by western blotting. Suppression of histone deacetylase 6 activity significantly compromised the
BURKITT-LYMPHOM (PATHOLOGIE); ZELLLINIEN + ZELLLINIENISOLIERUNG (CYTOLOGISCHE METHODEN); EPSTEIN-BARR-VIRUS (VIROLOGIE); TRANSKRIPTION (MOLEKULARE GENETIK); DNA-MIKROARRAY TECHNOLOGIE; BURKITT LYMPHOMA (PATHOLOGY); CELL LINES + CELL LINE ISOLATION (CYTOLOGICAL METHODS); EPSTEIN-BARR-VIRUS (VIROLOGY); TRANSCRIPTION (MOLECULAR GENETICS); DNA ...
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA methylation and diminished PUMA expression, which can be reactivated following inhibition of DNA methyltransferases. These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics.. ...
Get information, facts, and pictures about Burkitt lymphoma at Encyclopedia.com. Make research projects and school reports about Burkitt lymphoma easy with credible articles from our FREE, online encyclopedia and dictionary.
HLDA WorkshopHLDA VI-WS Code AS A048 Concentration Unitmg/mLConcentration1Quantity0.1 mgVolume0.1ImmunogenRaji cells: human Burkitts lymphoma cell...
Burkitt is an ancient name of Anglo-Saxon origin, and may refer to: Denis Parsons Burkitt, surgeon Francis Crawford Burkitt, British theologian Jack Burkitt, English footballer James Parsons Burkitt, ornithologist M. C. Burkitt, British palaeohistorian William Burkitt, biblical expositor and vicar in Dedham, Essex, England Judge Sir William Burkitt Burkitts lymphoma Burkitt name origin Alternative origin of Burkitt ...
Burkitts lymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. We examined the potential role of the p53 gene in BL tumorigenicity using an in vitro assay that measures p53-dependent cell cycle arrest in the G1 phase of the cell cycle and an in vivo athymic murine model that detects differences in the tumorigenicity of BL cell lines. A highly significant inverse correlation was found between the ability of BL cells to arrest in G1 after irradiation and their tumorigenicity in athymic mice, consistent with the notion that loss of p53 function is associated with increased tumorigenicity. Inactivation of wild-type (wt) p53 function by expression of the human papillomavirus E6 protein in the AG876V BL cell line, which carries both wt and mutant p53 proteins, rendered the cell line significantly more tumorigenic in athymic mice. Transfection of the wt p53 gene into the p53 mutant and highly tumorigenic BL-41 cell line ...
HLDA WorkshopHLDA 10Quantity100 testsVolume0.4ImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane glycopro...
Burkitts lymphoma is a sort of aggressive B-cell lymphoma. This condition is most usually observed in youngsters and isolated into three types:. - Endemic - this is generally seen in children living in Africa. Usually, this kind of Burkitts lymphoma affects the facial bones such as the jaw, the intestines such as the distal ileum and cecum. Other stomach parts such as the ovaries and kidneys can also be affected.. - Sporadic/Non-African - found outside of Africa and affects the same parts as that of the endemic mixed bag.. - Immunodeficiency associated - this kind of Burkitts lymphoma is usually seen in HIV patients or patients taking insusceptible suppressive drugs.. Causes. Alongside the stated associated factors, Burkitts lymphoma is exceptionally joined with Epstein-Barr virus and jungle fever. The virus creates a change inside the B-cells, a kind of lymphocyte found in the safe system. Exposure to jungle fever weakens the cells resistance to the virus effects, making it one of the ...
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
Background. Between 1991 and 1997, limited funding at times restricted available treatment for children with Burkitt lymphoma (BL) to cyclophosphamide (CPM) monotherapy at Lilongwe Central Hospital, Malawi. Our objective was to assess long-term survival in Malawian children with Burkitt lymphoma (BL) who had received one or more treatments with intravenous CPM at 40 mg/kg/dose at 14-day intervals. Procedure and Results. The study population consisted of 92 children in whom BL had been confirmed on fine needle aspirates (FNA), a home address had been documented on discharge from hospital, and the treatment records could be verified. Only the clinical site(s) of disease had been recorded. The M:F ratio was 1.4 and median age 8 years. A clinical officer on motorcycle attempted to locate the given addresses and interview parents or other sources. In 19 patients, the address was incorrect. Of 73 evaluable patients, 40 children are alive at a mean follow-up time of 59 (range: 29-104) months. The ...
Shahzad Ali Jiskani, Asfa Zawar and Lubna Naseem. Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad. Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad. Abstract: Burkitt lymphoma is a disease of young population; especially children. It rarely occurs and presented in elderly group. World Heal Organization (WHO) divided Burkitt lymphoma in endemic, sporadic and immunodeficiency - associated. The non - endemic variant occur in children with abdominal involvement. We report a sporadic case presented at the age of 61 years old male with irregular thickening or parietal peritoneum and omentum without involving any lymph nodes. ...
Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To elucidate molecular mechanisms regulating the development of apoptosis resistance, a panel of 15 BL cell lines was investigated for apoptosis induction upon treatment with microtubule inhibitors taxol, nocodazole and vincristine. Significant differences were observed in the extent of apoptosis induction among BL cell lines examined. Interestingly, cell lines exhibiting resistance to taxol- or nocodazole-induced apoptosis, showed development of polyploidy (,4N) and vice versa, displaying an inverse relationship between apoptosis and polyploidy induction. Further, in sensitive cell lines taxol-induced apoptosis was accompanied by caspase activation, Bid cleavage and Mcl-1 down-regulation. In contrast, most apoptosis resistant cell lines exhibited a loss of Bax and Bak expression and showed prolonged mitotic arrest with ,4N DNA content upon treatment. To gain mechanistic ...
In Burkitt lymphoma the c-myc gene, the cellular homologue of the viral oncogene v-myc, has been implicated in the aetiology of this human B-cell malignancy. Burkitt lymphoma cells possess specific chromosomal rearrangements involving the region proximal to the c-myc gene and one of the three human immunoglobulin loci. The nature of the effect exerted by the immunoglobulin loci on the translocated c-myc gene is controversial: whereas some reports have suggested c-myc transcription is elevated in Burkitt lymphoma cells, others have suggested the level of transcription is unaffected by the translation. Recently, transcription enhancer elements have been identified in the intron between the JH and C mu segments of the heavy-chain immunoglobulin gene in mice. If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. We report here the identification of an enhancer element adjacent to the human C mu
Epstein-Barr virus (EBV) has been causally associated with at least five human malignancies. The exact contributions made by EBV to these cancers remain unknown. We demonstrate that one viral protein found in all EBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitts lymphoma. Inhibition of EBNA-1 decreases survival of these tumor cells by inducing apoptosis. Expression of EBNA-1 in uninfected cells also can inhibit apoptosis induced by expression of p53 in the absence of the EBV genome. Our findings demonstrate that EBNA-1 is critical for the continued survival of EBV-associated Burkitts lymphoma, and, by extension, for the other B cell tumors with which EBV is associated. Efficient inhibitors of EBNA-1s functions would likely prove useful in the therapy of EBV-associated malignancies.
Zhou P, Newman AM, Van Noorden S, Banda K, Chagaluka G, Lampert I, Erhorn A, Bacon C, Bailey S, Molyneux E, Rand V. Investigation of prognostic markers in endemic Burkitt lymphoma. In: Fifth International Symposium on Childhood Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell Publishing Ltd ...
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression. We identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt lymphoma and regulated in the same direction by MYC in the model cell lines. Among them, we focused on a lncRNA that we named MYC-induced long noncoding RNA (MINCR), showing a strong correlation with MYC expression in MYC-positive lymphomas. To understand its cellular role, we performed RNAi and found that MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes ...
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitts lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable ...
SAL is a Gb3 (Galα1-4Galβ1-4Glc)-binding lectin with three SUEL-type lectin domains which was purified from catfish eggs. The lectin depleted expression of mRNA coding multidrug resistant protein, MRP1, time- and dose-dependently through binding with Gb3 glycosphingolipid which is highly expressed on human Burkitts lymphoma Raji cells. This interaction inhibited the excretion of chemotherapy drugs. The administration of vincristine could effectively killed Raji cells even at l/10 lower concentration than the lethal-doses, if co-treatment with SAL was conducted. The Japanese Association for Marine Biology (JAMBIO) in MEXT Japan identified this research as a leading edge topic as part of their 2012 research activities reporting. These results were possible through the work of Assist. Profs. Yuki Fujii (Nagasaki International University and adjunct researcher of Yokonama City University) and Shigeki Sugawara (Tohoku Pharmaceutical University), Assoc. Prof. Sarkar M. Abe Kawsar (University of ...
In raising murine hybridoma antibodies against Epstein-Barr virus (EBV)-induced membrane antigens (MA), we found one antibody that blocked the release of infectious EBV from cultured P3HR-1 cells. This monoclonal antibody (mAb) recognized a 200 kD, phosphonoacetic acid-sensitive (late) MA, and did not directly neutralize virus without complement. When this mAb was added to 33 degrees C-cultured, spontaneously EBV-producing P3HR-1 cells, the intracellular expression of viral capsid antigen and infectious virus was not inhibited, but the appearance of infectious virus in the culture medium was significantly reduced. The duration of this suppression was dependent upon the concentration of the mAb, an effect being observed to a 1:4 X 10(5) titer of the ascites mAb preparation. A more acute effect of suppression of EBV release was observed in a second model of 12-o-tetradecanoyl phorbol-13-acetate and n-butyrate induction of EBV in 37 degrees C-cultured P3HR-1 cells. Again, intracellular infectious ...
The study of Burkitts lymphoma is now in its 6 decade beginning with its discovery by Dr. Dennis Burkitt in equatorial Africa in the mid to late 1950s. A large body of information is available which provides a current understanding of the underlying molecular changes that are linked to the initiation and development of Burkitts lymphoma. This proposed volume will provide a comprehensive view of Burkitts Lymphoma from the diagnosis to potential animal models for this disease and include a view from physicians who have a up close view of the patients in populations where the disease is rampant. We expect that this will be an excellent resource for Medical students and faculty as well as educated laypersons who have a person interest in the disease ...
Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, a surgeon who first described the disease in 1958 while working in equatorial Africa. Currently, Burkitt lymphoma can be divided into three main clinical variants: the endemic, the sporadic, and the immunodeficiency-associated variants. The endemic variant (also called "African variant") most commonly occurs in children living in malaria endemic regions of the world (e.g., equatorial Africa, Brazil, and Papua New Guinea). Epstein-Barr virus (EBV) infection is found in nearly all patients. Chronic malaria is believed to reduce resistance to EBV, allowing it to take hold. The disease characteristically involves the jaw or other facial bone, distal ileum, cecum, ovaries, kidney, or breast. The sporadic type of Burkitt lymphoma (also known as "non-African") is the most common variant found in places where malaria is not holoendemic. The tumor cells ...
Burkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, that is, the translocation t(8;14)(q24;q32) or its variants. However, diagnostic dilemmas may arise in daily practice due to overlap of BL with subsets of other aggressive, mature B-cell lymphomas such as diffuse large B-cell lymphomas (DLBCL). Recently, two gene expression studies have described a distinct molecular profile for BL, but also showed the persistence of some cases intermediate between BL and DLBCL. An alternative approach to define BL is to consider (cyto)genetic data, in particular chromosomal abnormalities other than the t(8;14) or its variants. In this review the Mitelman Database of Chromosome Aberrations in Cancer, harboring the majority of all published neoplasia-related karyotypes, was explored to define a cytogenetic profile of true BL. This core subset of BL showed a very low complexity of chromosomal abnormalities with 40% of the cases ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Burkitt lymphoma/leukemia (BL) is highly treatable, but most of the standard therapies require multiple doses of intensive chemotherapy that may require long hospital stays and frequently have severe side effects. In addition, BL is a fairly common type of cancer in patients who also have human immunodeficiency virus (HIV), but treatment outcomes are poor because standard treatments do not work very well in HIV-positive patients and the more intense treatment regimens are highly toxic. New approaches are needed that expand the ways to treat BL with the same efficiency but with reduced side effects ...
Burkitt lymphoma/leukemia (BL) is highly treatable, but most of the standard therapies require multiple doses of intensive chemotherapy that may require long hospital stays and frequently have severe side effects. In addition, BL is a fairly common type of cancer in patients who also have human immunodeficiency virus (HIV), but treatment outcomes are poor because standard treatments do not work very well in HIV-positive patients and the more intense treatment regimens are highly toxic. New approaches are needed that expand the ways to treat BL with the same efficiency but with reduced side effects ...
Burkitt lymphoma is a rare, fast-growing form of non-Hodgkin lymphoma (NHL). Its a type of cancer of the lymphatic system. The lymphatic system is part of the immune system. It helps to fight diseases and infections.
Burkitt lymphoma is a rare, fast-growing form of non-Hodgkin lymphoma (NHL). Its a type of cancer of the lymphatic system. The lymphatic system is part of the immune system. It helps to fight diseases and infections.
the treatment of Burkitt lymphoma were described. It was also mentioned that the the scientific committee of one of the must prestigious meetings on lymphoid neoplasia, held in Lugano every 3 years, had selected the project for oral presentation. Since then, Dr Valeria Calbi, who coordinates the study at St Marys Hospital, Lachor has given the presentation, which was extremely well received. The remarkably high survival rate of 71% at 3 years is a result of INCTRs long standing interest in the disease, (which is the most frequently observed lymphoma in Ugandan children and accounts for half of all pediatric cancers), and its efforts to demonstrate what can be achieved in Africa with due attention to the basic principals of oncology. An extensive analysis of the detailed information that has been collected in patients treated with the treatment protocol described by Dr Calbi has been performed. This work was made possible with the help and support of Nick and Emma Seaford (see picture), who, as ...
Burkitts lymphoma is a mature B-cell lymphoma associated with Epstein-Barr-virus that is characterized by rapid proliferation and a propensity for extranodal sites of involvement such as the gastrointestinal tract and central nervous system. It affects primarily children and young adults. Since sonography is often the first imaging procedure performed in these patients, knowledge of the wide range of sonographic appearances is helpful for the recognition of Burkitts lymphoma. Burkitts lymphoma appears to be curable in a high proportion of cases if treated with aggressive multiagent chemotherapy regimens.The use of autologous stem cell transplantation appears to benefit patients who have had chemotherapy-sensitive relapses. ...
Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Using the methods employed to produce national estimates of cancer incidence for the
Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Using the methods employed to produce national estimates of cancer incidence for the
Moormann, Ann M. and Lozada, Jose S., "Burkitt lymphoma in Uganda: 50 years of ongoing discovery" (2008). Quantitative Health Sciences Publications and Presentations. 414 ...
What does ABL stand for? Hop on to get the meaning of ABL. The Acronym /Abbreviation/Slang ABL means African Burkitt lymphoma. by AcronymAndSlang.com
Burkitt lymphoma Diagnos (costs for program #275118) ✔ University Hospital Münster ✔ Department of Pediatric Hematology and Oncology ✔ BookingHealth.com
Orbis Research: Statistical Analysis for Global Burkitt Lymphoma Market capacity, production, production value, cost/profit, supply/demand and import/expor
Evidence linking Epstein-Barr (EB) virus to two human cancers, endemic Burkitts lymphoma (BL) (Burkitt, 1963) and undifferentiated nasopharyngeal carcinoma (NPC) (Shanmugaratnam, 1971), has...
Raji Cell Slide (Human (11yrs, Male) B lymphocyte Burkitts lymphoma) (5 slides/pk) Slide for ICC HCLS-17007 Raji Cell Slide (Human (11yrs, Male) B lymphocyte Burkitts lymphoma) (5 slides/pk) Slide for ICC HCLS-17007
Burkitts lymphoma definition is - a non-Hodgkins lymphoma of B cell origin that occurs especially in children of central Africa and is associated with Epstein-Barr virus.
Structural derivatives of 4-MTA, an illegal amphetamine analogue have been previously shown to have anticancer effects in vitro. In this study we report the synthesis of a series of novel 1,3-bis(aryl)-2-nitro-1-propene derivatives related in structure to 4-MTA. A number of these compounds containing a classic nitrostyrene structure are shown to have antiproliferative activities in vitro in a range of malignant cell lines, particularly against Burkitt?s lymphoma derived cell lines, whilst having no effect on `normal? peripheral blood mononuclear cells. Such effects appear to be independent of the serotonin transporter, a high affinity target for amphetamines and independent of protein tyrosine phosphatases and tubulin dynamics both of which have been previously associated with nitrostyrene-induced cell death. We demonstrate that a number of these compounds induce caspase activation, PARP cleavage, chromatin condensation and membrane blebbing in a Burkitt?s lymphoma-derived cell line, consistent ...
Burkitts lymphoma is a cancer of the lymph nodes which mostly affects children. This disease was first discovered in young children in certain parts of Africa. Nowadays it is found everywhere. The lymphatic system which comprises the lymph vessels, lymphocytes, lymph nodes, spleen, bone marrow and thymus is a part of the immune system and it combats diseases and infections. The lymph nodes in the groin, neck and under arms swell and grow rapidly.. Though they are painless, they can cause, fever, night sweats and undue loss of weight. This disease, caused by the Epstein Barr virus usually affects the abdomen and spreads to the other parts of the body. It can even affect the brain as it progresses very quickly. Not all Burkitts lymphoma have viral origins. People with a weak or malfunctioning immune system and those who have HIV are at a greater risk of having this disease.. ...
Burkitts lymphoma is an uncommon and aggressive type of Non-Hodgkins lymphoma and is one of the fastest growing cancer tumour in humans; growth fraction close to 100%. We report a case of a young adult female presented with acute pain abdomen with ileo-caecal mass. On clinical presentation, initial diagnosis was acute appendicitis with lump formation. Ultrasound reported as diffuse inflammatory changes and later CECT was done which reported as Gastro-Intestinal Stromal Tumour (GIST). On laparotomy, a huge hard mass was found on ileo-caecal region and right hemicolectomy was done. Diagnosis was confirmed as Non-Hodgkins Burkitts Lymphoma by HPE and immunohistochemistry testing. So, careful workup is the key to initiate early treatment. This patient had complete remission after the right hemicolectomy followed by multiagent chemotherapy.
Dr.Meenesh Juvekar. M.S (ENT), D.N.B, D.O.R.L, M.N.A.M.S (Ear-Nose-Throat & Head Neck surgeon) Call 91+022-25271150 for appointment
The TWiVniks consider the role of a cell enzyme in removing a protein linked to the 5′-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitts lymphoma.. ...
CC: CCSD:43026 AU: Taga S; Mangeney M; Tursz T; Wiels J TI: Differential regulation of glycosphingolipid biosynthesis in phenotypically distinct Burkitts lymphoma cell lines CT: Int J Cancer (1995) 61: 261-267 [PMID:7705957] BS: (CN) human, (disease) Burkitts lymphoma, (cell line) BL10, Daudi, Ramos, Ly47, Ly67, MUTU III, BL36 TN: GM2 MT: ganglioside MT: glycolipid MT: glycosphingolipid SB: Westra B DA: 23-09-1995 FC: f7673cea SI: CBank:16359 ---------------- structure: b-D-GalpNAc-(1-4)+ , b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Ceramide , a-D-Neup5Ac-(2-3)+ ================end of record ...
A case of Japanese Burkitts lymphoma associated with EB virus.: A 6-year-old girl was admitted for cervical lymphadenopathy. She was diagnosed histologically a
By:(A Burkitts lymphoma patient/survivor). As you are waiting to be diagnosed and treated you are going to learn of a lot of things you probably never heard of before, words, acronyms or phrases like LDH, lumbar puncture, PET scan, CT scan, and bone marrow biopsy to name a few. We are going to discuss these in detail below, because some of these or all will be used in diagnosing, monitoring and the routine maintenance of a Burkitts lymphoma patient including me.. BIOPSY. The Diagnosis of Burkitts lymphoma comes in the form of a biopsy. A Biopsy is basically taking a sample of the suspected tissue and or cells and putting it through an array of tests at a laboratory to see what it is. There are several different types of Biopsies such as endoscopic, needle biopsy and surgery to name some of the the most popular. I was diagnosed by biopsy after having found a mass with a chest x-ray. Some biopsies are invasive some are not. Your particular case will depend on what you end up with. I recently had ...
Epstein-Barr Virus (EBV) is an oncogenic human herpesvirus predominantly infecting B-lymphocytes that is etiologically associated with Burkitts lymphoma, AIDS-...
Lymphomas are cancers classified mostly according to the type of white cell involved. Burkitts lymphoma starts in B-lymphocytes, so-called because they mature in the bone marrow of many bones.
Burkitts lymphoma (BL) is a neoplasm which, despite its very aggressive behaviour is potentially curable. It typically affects the paediatric population. BL belongs to the non-Hodgkin lymphomas group, and is the first human tumour undoubtedly relate
Gentaur molecular products has all kinds of products like :search , Biochai \ cDNA _ Human Tumor Cell Line Raji \ C1255840 for more molecular products just contact us
BioAssay record AID 165916 submitted by ChEMBL: In vitro toxicity against Burkitts lymphoma (B-cell) (Raji) at a concentration of 0.1 ug/ml.
TO THE EDITOR:. We thank Ralf Küppers for his interest in our article1 and for his thoughtful commentary.2 We address each of the points he raises below.. First, Küppers claims that, in contrast to what has been demonstrated in mice,3 not all normal human B-cell progenitors undergo concurrent biallelic DHJH rearrangement during B-cell development, and he cites an analysis performed with Southern blot techniques of 26 B-cell lines derived from 3 individuals to support this claim.4 We analyzed publicly available IGH high-throughput sequencing (HTS) data derived from analysis of B-cell genomic DNA from 60 healthy individuals (available at https://clients.adaptivebiotech.com/immuneaccess), and we conclude that the data strongly suggest that a very high fraction of normal human B cells do indeed undergo biallelic DHJH rearrangement. These IGH HTS data were acquired using the same sequencing platform used for our studies.5 A total of 2 604 887 unique IGH nucleotide sequences, comprising productive ...
MeSH-minor] Abdominal Neoplasms / classification. Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / pathology. Adolescent. Antigens, CD / analysis. Austria / epidemiology. Biopsy, Fine-Needle. Burkitt Lymphoma / diagnosis. Burkitt Lymphoma / pathology. Cell Nucleus / ultrastructure. Cell Size. Child. Child, Preschool. Cytoplasm / ultrastructure. Early Diagnosis. Feasibility Studies. Female. Humans. In Situ Hybridization, Fluorescence. Infant. Lymphocyte Subsets / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology. Male. Mediastinal Neoplasms / classification. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Prospective Studies. Staining and ...
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Type of B-cell lymphoma first described by Dennis Burkitt who was working in Africa at the time. The disease was common to the children of that region. Research later showed that these children had been infected with the Epstein-Barr virus. Because these children had lowered immune systems to begin with in some cases the virus they were infected with changed the B-lymphocytes into cancerous cells.
...WASHINGTON (Dec. 11 2012) New research presented this morning at t...Unlike previous studies in which malaria infection alone was considere...The study titled Risk of Burkitt Lymphoma Correlates with Breadth an...The GW SMHS research team developed optimized and standardized an ex...,New,research,helps,predict,susceptibility,to,Burkitt,lymphoma,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing ...
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing ...
B-cell, Lymphomas, B-cell Lymphoma, Lymphoma, Tumors, Burkitt Lymphoma, Tumor, Cancer, Disease, DNA, Exomes, Gene, Genes, Genome, Mutations, Kinase, Adaptive Immunity, B Cells, Cell, Cell Differentiation
GA-10 (Clone 4) is a subclone of the GA-10 (ATCC CRL-2392) cell line derived by culturing the parental line on a feeder layer. GA-10 was derived in 1996 from lymphoma cells circulating in the peripheral blood of a patient with a clinically aggressive, chemo-refractory Burkitts Lymphoma.  
Lillie was a vibrant and active 13 year old but in mid-February of 2014. She suddenly was suffering from pain and constant vomiting. Of course, she and her family assumed it was the flu. However, after 11 days and three visits to doctors, a small tumor was found on her intestine. It was then that Lillie was diagnosed with Burkitt Lymphoma, an aggressive and fast growing tumor but, a treatable one.
My husband has Burkitt Lymphoma, but they say it is in the early stages, and they are putting him in the hospital for chemo on Monday. He will probably be there a week. After that, who, team43873board
This line was derived from the Ramos (RA-1) cell line (see ATCC CRL-1596) by repetitive cloning with selection for low constitutive expression of CD23 and maximum stimulation of CD23 expression by IL-4.
ARLINGTON- Shirley Winifred Thompson Hilchey, 86, died Thursday, March 5, surrounded by family and friends at her home, after a brief battle with cancer (Burkitts lymphoma). Mrs. Hilchey was born in Chester to Adolphus Joseph Thompson and Winifred Darling Hazeltine on March 27, 1933. Her husband of nearly 60 years, Robert Lincoln Hilchey, died on July 26, 2010.
NEW YORK - When he heard his name called, it took Cam Newton only three enormous strides to make up the distance between he and Alan Casey, the 13-year-old with Burkitts lymphoma who was announcing Newton at the post-Heisman press conference as part of the Make-A-Wish Foundation.. ...
Endemic Burkitt is highly associated with EBV infection. , 30% of sporadic Burkitt lymphomas are EBV positive.. HIV-associated Burkitt is associated with HIV or other causes of immunodeficiency.. Epidemiology:. Endemic Burkitt lymphoma is endemic to equatorial Africa and South America. The sporadic and endemic types are more common in children while the HIV-associated type is more common in adults.. Clinical features:. Sporadic Burkitt often presents as an abdominal mass. It can be a cause for ileus. Endemic Burkitt usually presents as a mass in the maxilla or mandibula.. Pathology:. The tumor cells have very high rate of proliferation, and apoptosis is widespread. Tingible body macrophages phagocytose the apoptotic bodies, which causes the "starry sky" pattern on histology.. Treatment:. Burkitt tumours are highly chemosensitive. Patients with large tumours are at increased risk for tumor lysis syndrome.. ...
TY - JOUR. T1 - Adult high-grade B-cell lymphoma with Burkitt lymphoma signature. T2 - Genomic features and potential therapeutic targets. AU - Bouska, Alyssa. AU - Bi, Chengfeng. AU - Lone, Waseem. AU - Zhang, Weiwei. AU - Kedwaii, Ambreen. AU - Heavican, Tayla. AU - Lachel, Cynthia M.. AU - Yu, Jiayu. AU - Ferro, Roberto. AU - Eldorghamy, Nanees. AU - Greiner, Timothy Charles. AU - Vose, Julie Marie. AU - Weisenburger, Dennis D.. AU - Gascoyne, Randy D.. AU - Rosenwald, Andreas. AU - Ott, German. AU - Campo, Elias. AU - Rimsza, Lisa M.. AU - Jaffe, Elaine S.. AU - Braziel, Rita M.. AU - Siebert, Reiner. AU - Miles, Rodney R.. AU - Dave, Sandeep. AU - Reddy, Anupama. AU - Delabie, Jan. AU - Staudt, Louis M.. AU - Song, Joo Y.. AU - McKeithan, Timothy W.. AU - Fu, Kai. AU - Green, Michael. AU - Chan, Wing C.. AU - Iqbal, Javeed. PY - 2017/10/19. Y1 - 2017/10/19. N2 - The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma (BL) are highly aggressivelymphomas with ...
The Epstein-Barr Virus Capsid Antigen (VCA) IgM ELISA Kit is intended for the measurement of IgM antibodies to Epstein-Barr Virus Capsid Antigen (VCA) in a sample. This kit utilizes Epstein-Barr VCA antigen (P3H3 cell extract, cultured in human Burkitt lymphoma cells).
en] Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitts lymphoma. This is a rare location of sporadic Burkitts lymphoma with neurologic syndrome as first symptoms ...
Mild hyperthermia is known to enhance apoptosis in a range of normal and neoplastic cell populations. Studies of tumours previously shown to respond to heating in this manner might be expected to provide insights not only into the mechanism of hyperthermic cell killing, but also into the apoptotic process in general. In the present study, cell death induced by 43°C heating for 30 min in two human Burkitts lymphoma lines, BM 13674 and WW1, and in murine mastocytoma P‐815 × 2·1 was found to be exclusively apoptotic in type, identification being based on light and electron microscopic appearances and on the presence of internucleosomal cleavage of DNA into fragments that are multiples of 180-200 base pairs, which was demonstrated by agarose gel electrophoresis. The heat‐induced apoptosis was prevented by the presence of zinc sulphate, an inhibitor of the endonuclease considered to be responsible for the DNA cleavage, but was not suppressed by the protein synthesis inhibitor cycloheximide. ...
Piperlongumine (PL), a pepper plant alkaloid from Piper longum, kills solid tumor cells in a highly selective, potent fashion. To evaluate whether PL may have similar effects on malignant blood cells, we determined the efficacy with which PL inhibits the B-lymphocyte derived neoplasm, Burkitt lymphoma (BL). Low micromolar concentrations of PL (IC50=2.8μM×8.5μM) curbed growth and survival of two EBV+ BL cell lines (Daudi, Raji) and two EBV BL cell lines (Ramos, DG-75), but left normal peripheral blood B-lymphocytes unharmed. PL-dependent cytotoxicity was effected in part by reduced NF-κB and MYC activity, with the former being caused by inhibition of IκBα degradation, nuclear translocation of p65, and binding of NF-κB dimers to cognate DNA sequences in gene promoters. In 4 of 4 BL cell lines, the NF-κB/MYC-regulated cellular target genes, E2F1 and MYB, were down regulated, while the stress sensor gene, GADD45B, was up regulated. The EBV-encoded oncogene, LMP-1, was suppressed in Daudi and ...
Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and to determine the importance of these mechanisms in a translational system moving from a mouse model to human malaria. The most frequently cited immunological consequences of malaria are: suppression of vaccine responses, susceptibility to bacterial infection, susceptibility to endemic Burkitt lymphoma, and increased HIV viral load. Of these, susceptibility to non-Typhoid Salmonella (NTS) bacteremia, associated with severe hemolysis, was the most consistent between animal and human studies. I hypothesized that hemolysis would induce the immunomodulatory enzyme heme oxygenase-l (HO-l), which is essential for survival in malaria infections in mice, but might impair host defence against NTS. I demonstrate in mice that malaria, chemically-induced ...
A bispecific monoclonal antibody is made up of two different monoclonal antibodies that bind to two different substances and kills cancer cells. Bispecific monoclonal antibody therapy is used in the treatment of Burkitt and Burkitt-like lymphoma/leukemia and diffuse large B-cell lymphoma.. Tyrosine kinase inhibitors (TKIs) block signals that tumors need to grow. Some TKIs also keep tumors from growing by preventing the growth of new blood vessels to the tumors. Other types of kinase inhibitors, such as crizotinib, are being studied for childhood non-Hodgkin lymphoma.. Immunotoxins can bind to cancer cells and kill them. Denileukin diftitox is an immunotoxin used to treat cutaneous T-cell lymphoma.. Targeted therapy is being studied for the treatment of childhood non-Hodgkin lymphoma that has recurred (come back).. See Drugs Approved for Non-Hodgkin Lymphoma for more information.. Other drug therapy. Retinoids are drugs related to vitamin A. Retinoid therapy with bexarotene is used to treat ...
Burkitt-like post-transplant lymphoproliferative disorder (PTLD) presenting with breast mass in a renal transplant recipient: a report of a rare case. Law, Man; Chan, Hay; Leung, Charlotte; Lai, Ho; Ha, Chung; Ng, Celia; Yeung, Yiu; Yip, Sze // Annals of Hematology;Dec2014, Vol. 93 Issue 12, p2083 A letter to the editor is presented in response to the article which discusses the Burkitt-like post-transplant lymphoproliferative disorder (PTLD) with breast mass in a renal transplant recipient that was published in the one of the previous issue of the periodical. ...
Burkitts lymphoma, Burkitts tumor A form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma. The Epstein-Barr virus (EB virus), a gammaherpes virus, has been isolated from Burkitts lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans. Also known as Burkitts Lymphoma ...
Looking for online definition of Burkitts lymphoma in the Medical Dictionary? Burkitts lymphoma explanation free. What is Burkitts lymphoma? Meaning of Burkitts lymphoma medical term. What does Burkitts lymphoma mean?
Updated cell lines for exosome production includes also HEK293 cell line (Human Embryonic Kidney cells 293). Lyophilized and purified exosomes from cell culture medium. • PC3 cell line (human prostate adenocarcinoma grade IV) • BPH-1 cell line (human being prostatic hyperplasia) • DAUDI cell line (human burkitt lymphoma) • A549 cell line (lung carcinoma) • K-562 cell line (pleural effusion, leukemia chronic myelogenous) • B16F10 mouse cell line (mouse melanoma cell line) • HEK293 cell line (human embryonic kidney) Lyophilized Exosome Standards. Lyophilization is the ideal technique for preserving the long-term stability of exosomes at 4 .. Lyophilized exosomes can be used as control standards for multiple applications including FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.. Lyophilized exosomes are easy to ship and store, and are stable for 12 months at 4 . Purified and lyophilized exosomes are obtained from a ...
The virus in the EB-3 cell line derived from a Burkitt lymphoma was partially purified by digestion with proteolytic enzyme and by density-gradient centrifugation on potassium tartrate. Electron microscope studies of both sectioned and negatively stained samples suggest that the virus belongs to the herpes-virus group, although the exact number of capsomeres was not unequivocally established. ...
Incorporation of thalidomide, lenalidomide, and pomalidomide into the myeloma therapeutic armamentarium has contributed substantially to patient survival. Given the contributory role, EBV plays in approximately 50% of Hodgkin lymphoma, and reports of Hodgkin lymphoma in patients on lenalidomide-MT, we hypothesized that lenalidomide, and its analogues thalidomide and pomalidomide, may induce EBV reactivation. This hypothesis was further supported by the fact that the immunosuppressant methotrexate in nonmalignant diseases such as rheumatoid arthritis enhanced the risk of EBV-positive lymphomas (9). In this study, we found that LTP reactivated EBV in latently infected B-cell lines in the order of efficacy pomalidomide , lenalidomide , thalidomide. LCL cells were weakly inducible into lytic cycle, whereas Burkitt lymphoma cells were readily induced (Fig. 1). Combinations of ganciclovir with lenalidomide or pomalidomide enhanced the growth inhibitory effect in Burkitt lymphoma cells (Fig. 2C and ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Induction of Epstein-Barr Virus Lytic Replication Beth Israel Deaconess Medical Center, Boston, Dr. Joyce Fingeroth Student Presenter: Anastasia Hyrina Project Advisor: Craig Woodard Epstein-Barr virus (EBV) is a member of the herpesvirus family and is one of the most common human viruses. In the United States, 95% of adults between 35 and 40 years of age have been infected with EBV1. EBV is the etiological agent of infectious mononucleosis and is associated with a number of diverse lymphomas and epithelial cancers, including African Burkitts lymphoma, nasopharyngeal carcinoma and gastric malignancies2. Though EBV primarily infects B lymphocytes and epithelial cells, the sequence of infection is not well understood. In infected B cells, EBV establishes persistent latent infections. The latent state of the virus in a cell is characterized by expression of a small subset of viral genes and the latent membrane proteins, which are essential for induction and maintenance of cellular proliferation ...
BL occurs as an Epstein-Barr virus (EBV) associated malignancy among children in the malaria belt of equatorial Africa (endemic BL),5 and sporadically in other geographical areas, where it also occurs among adults (sporadic BL).6,7 The most common site of involvement of endemic BL is the kidneys. Jaw tumours are age related with an overall incidence in Uganda of 50%.7 In contrast, the terminal ileum and lymph nodes are the more commonly involved sites in sporadic BL.8,9 A common translocation t(8;14) and the consequent c-myc rearrangement and overexpression have been identified in endemic and sporadic BL. However, some not very strict associations between JH and DH recombination have been identified at 14q32, with distant 5 c-myc recombination in endemic cases of BL, whereas in sporadic cases Sμ and Sα recombination was identified10 at 14q32, with near 5 or intronic c-myc recombination at 8q24. These differences between endemic and sporadic BL do not mean that each of these subtypes of ...
Read the Burkitt surname history and see the family crest, coat of arms for the English Origin. Discover the Burkitt surname history. Where did the name Burkitt come from?
Background During B-cell development, precursor B-cells transiently express the pre-B-cell receptor composed of μ heavy chain complexed with VpreB and λ5 surrogate light chain polypeptides. Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B-cells and Burkitt lymphoma. Design and Methods Here, we used a novel antibody to investigate the normal expression pattern of VpreB3 protein in human hematolymphoid tissues, and determine whether VpreB3 can serve as a useful diagnostic biomarker for select B-cell lymphomas. Results We found that VpreB3 protein is normally expressed by precursor B-cells in bone marrow and by a subset of normal germinal center B-cells in secondary lymphoid organs. Among lymphoid malignancies, we found an association between VpreB3 expression and B-cell tumors with c-MYC abnormalities. VpreB3 was highly expressed in all cases of Burkitt lymphoma, whether of endemic or sporadic origin (44/44 ...
The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitts lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.
1. Dang C V. MYC on the Path to Cancer. Cell. 2012;149(1):22-35 2. Fernandez PC, Frank S R, Wang L. et al. Genomic targets of the human c-Myc protein. Genes & development. 2003;17(9):1115-1129 3. Li Z, Van Calcar S, Qu C. et al. A global transcriptional regulatory role for c-Myc in Burkitts lymphoma cell. PNAS. 2003;100(14):8164-8169 4. Lin CY, Lovén J, Rahl PB. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151(1):56-67 5. Zhang X, Zhao X, Fiskus W. et al. Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas. Cancer cell. 2012;22(4):506-523 6. Berg T. Small-molecule modulators of c-Myc/Max and Max/Max interaction. Curr Top Microbio Immunol. 2011;348:139-149 7. Lin CP, Liu CR, Lee CN. et al. Targeting c-Myc as a novel approach for hepatocellular carcinoma. World J Hepatol. 2010;2(1):16-20 8. Zhang W, Kater AP, Widhopf GF. et al. B-cell activating factor and v-Myc ...
Site: Primary cardiac lymphoma typically involves the right atrium, as a mass and is often associated with pericardial effusion. Involvement of the other chambers is less common. Most patients have pericardial involvement, but extension into the valves is rare. Reporting of Cardiac Tumours Type of Primary cardiac lymphomas : Non Hodgkins Type: (mostly of B-cell nature) - Low ; Intermediate ; High grade Microscopic diagnosis is based on the same criteria as applied in lymphomas in general. Case Link (NEJM) Cardiac lymphomas demonstrate a wide range of histologic types, including well-differentiated B-cell lymphomas, follicular center cell lymphomas, diffuse large cell lymphomas, and undifferentiated Burkitt-like lymphomas.. The tumour usually infiltrate the surrounding muscle and epicardial fat . In some cases it may infiltrate the adventitia of the coronary arteries.. Reporting of Endomyocardial Biopsy Diagnosis of lymphoma after cardiac transplantation should be done carefully, as there are ...
Researchers affiliated with the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) have reported that conventional chemoimmunotherapy was superior to sequential high-dose chemotherapy with autologous stem cell support for the treatment of high-risk patients with aggressive B-cell lymphoma. The details of this randomized study were presented at the 2011 meeting of the American Society of Clinical Oncology.. Non-Hodgkins lymphoma (NHL) is a form of cancer that begins in the cells of the lymph system. The lymph system includes the spleen, thymus, tonsils, bone marrow, lymph nodes, and circulating immune cells. The main cells in the lymph system are lymphocytes, of which there are two types: B- and T-cells. Each cell type has a specific function in helping the body fight infection.. Non-Hodgkins lymphoma is characterized by the excessive accumulation of atypical (cancerous) lymphocytes. These lymphocytes can crowd the lymph system and suppress the formation and function of other immune ...
TY - JOUR. T1 - Isolated third nerve palsy. T2 - A rare neurological presentation of Burkitts lymphoma. AU - Kalantri, Siddhesh Arun. AU - Nayak, Akshatha. AU - Datta, Saikat. AU - Bhattacharyya, Maitreyee. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Lymphoma patient presenting with isolated third nerve palsy is relatively rare, and diagnosis of underlying disease may be challenging. Until this date, less than 20 cases have been described in the literature. This is the case of a 3-year-old boy who presented to neurologist with ptosis of left eye for 8 days. On examination, abdominal mass was detected, and the child was referred to paediatric surgery department. Laparotomy and excision of the mass was done. Histopathology and immunohistochemistry of the mass confirmed it to be a case of Burkitts lymphoma. At this point, the patient was referred to haematology department. Contrast-enhanced CT brain showed infiltration around left cavernous sinus. Patient was treated with two cycles of R-CODOX-M/R-IVAC. ...
TY - JOUR. T1 - Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. AU - Bolt, Alicia M.. AU - Douglas, Randi M.. AU - Klimecki, Walter T.. PY - 2010/11/30. Y1 - 2010/11/30. N2 - Chronic exposure to inorganic arsenic is associated with diverse, complex diseases, making the identification of the mechanism underlying arsenic-induced toxicity a challenge. An increasing body of literature from epidemiological and in vitro studies has demonstrated that arsenic is an immunotoxicant, but the mechanism driving arsenic-induced immunotoxicity is not well established. We have previously demonstrated that in human lymphoblastoid cell lines (LCLs), arsenic-induced cell death is strongly associated with the induction of autophagy. In this study we utilized genome-wide gene expression analysis and functional assays to characterize arsenic-induced effects in seven LCLs that were exposed to an environmentally relevant, minimally cytotoxic, ...
Hypopituitarism is a rare presentation of Burkitts lymphoma (BL). The purpose of this report is to present a case of BL presenting with panhypopituitarism and to review other case reports of lymphoma presenting with pituitary dysfunction to highlight the distinguishing features of these cases from other benign aetiologies of pituitary dysfunction such as non-functioning pituitary adenomas. We reviewed a total of 11 cases of lymphoma presenting with pituitary dysfunction published from 1998 to 2013 including the present case. The demographics, clinical presentations, laboratory features, radiological findings, histological diagnosis, treatment administered and outcomes were described. Of the total number of patients, 45.5% of the cases had diffuse large B-cell lymphoma while 27.3% had BL. Anterior pituitary dysfunction was more common than posterior pituitary dysfunction at presentation. The other common associated presenting symptoms were painful ophthalmoplegia, cranial nerve palsies and ...
Epstein-Barr virus (EBV) encodes at least 25 pri-microRNAs (miRNAs) in two regions of its DNA genome, BART and BHRF. B95-8, an EBV reference strain, has a deletion in the BART region. However, no information is available on the deletions or mutations in the BART and BHRF regions in clinical samples of EBV-associated lymphoma. Nine DNA fragments encoding miR-BARTs and two coding miR-BHRF1s were amplified by PCR from DNA samples extracted from 16 cases of EBV-associated lymphoma. All the PCR products were sequenced directly. DNA fragments encoding miR-BARTs and miR-BHRF1-1 were successfully amplified from all samples. An adenine-to-guanine mutation in the DNA fragment encoding miR-BART2-3p was detected in four of the 16 cases, and a cytosine-to-thymidine mutation in the DNA fragment encoding miR-BART11-3p was detected in one of the 16 samples. These mutations were not associated with any histological categories of lymphoma. In conclusion, mutations were rarely observed in the DNA encoding viral miRNAs in
In chromosome translocations characteristic of Burkitt lymphomas (BL) and murine plasmacytomas, c-myc genes become juxtaposed to immunoglobulin heavy-chain (IgH) sequences, resulting in aberrant c-myc transcription. Translocated c-myc alleles that retain the first exon exhibit increased transcription from the normally minor c-myc promoter, P1, and increased transcriptional elongation through inherent pause sites proximal to the major c-myc promoter, P2, We recently demonstrated that a cassette derived from four DNase I-hypersensitive sites (HS1234) in the 3C alpha region of the IgH locus functions as an enhancer-locus control region (LCR) and directs a similar pattern of deregulated expression of linked c-myc genes in BL and plasmacytoma cell lines. Here, we report that the HS1234 enhancer-LCR mediates a widespread increase in histone acetylation along linked c-myc genes in Raji BL cells. Significantly, the increase in acetylation was not restricted to nucleosomes within the promoter region but ...
Lymphoma is cancer of the lymphatic_system. Lymphoma is broken down into two major types: hodgkins_disease and non-Hodgkins lymphoma. Various Types of Lymphoma (Not inclusive): adult T-cell lymphoma , adult T-cell leukemia/lymphoma see under leukemia. B-cell lymphoma any in a large group of non-Hodgkins lymphomas characterized by malignant transformation of the B lymphocytes. B-cell monocytoid lymphoma a low-grade lymphoma in which cells resemble those of hairy cell leukemia. Burkitts lymphoma a form of small noncleaved-cell lymphoma, usually occurring in Africa, manifested usually as a large osteolytic lesion in the jaw or as an abdominal mass; Epstein-Barr virus has been implicated as a causative agent. centrocytic lymphoma mantle cell l. convoluted T-cell lymphoma lymphoblastic lymphoma with markedly convoluted nuclei. cutaneous T-cell lymphoma a group of lymphomas exhibiting (1) clonal expansion of malignant T lymphocytes arrested at varying stages of differentiation of cells committed to ...

Burkitt Lymphoma Archives | Morgan Adams FoundationBurkitt Lymphoma Archives | Morgan Adams Foundation

What is Burkitt Lymphoma?. Burkitt lymphoma is a form of non-Hodgkins lymphoma which is a type of cancer that starts in the b- ... Burkitt lymphoma is one of the fastest growing tumors. Burkitt lymphoma attacks the immune system and is fatal if not treated ... What causes Burkitt lymphoma? Who is affected?. The exact cause of Burkitt lymphoma is unknown, but there are factors ... How is Burkitt lymphoma treated? The most common and effective treatment for Burkitt lymphoma is intensive intravenous ...
more infohttps://www.morganadamsfoundation.org/tumor-category/burkitt-lymphoma/

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets<...Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets<...

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets. Blood. ... Adult high-grade B-cell lymphoma with Burkitt lymphoma signature : Genomic features and potential therapeutic targets. In: ... High-resolution structural and functional genomic analysis of adult Burkitt lymphoma (BL) and high-grade B-cell lymphoma with ... High-resolution structural and functional genomic analysis of adult Burkitt lymphoma (BL) and high-grade B-cell lymphoma with ...
more infohttps://nebraska.pure.elsevier.com/en/publications/adult-high-grade-b-cell-lymphoma-with-burkitt-lymphoma-signature-

AIDS-Related Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Genesis HealthCare System - Zanesville, OhioAIDS-Related Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Genesis HealthCare System - Zanesville, Ohio

AIDS-related lymphoma is a disease in which malignant (cancer) cells form in the lymph system of patients who have acquired ... Burkitt or Burkitt-like lymphoma.. For more information about lymphoma or AIDS-related cancers, see the following PDQ summaries ... Non-Hodgkin lymphoma.. Both Hodgkin lymphoma and non-Hodgkin lymphoma may occur in patients with AIDS, but non-Hodgkin lymphoma ... When a person with AIDS has non-Hodgkin lymphoma, it is called AIDS-related lymphoma. When AIDS-related lymphoma occurs in the ...
more infohttps://www.genesishcs.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000257993

AIDS-Related Lymphoma in ChildrenAIDS-Related Lymphoma in Children

AIDS-related lymphoma is a type of cancer called non-Hodgkin lymphoma. It grows in some people with AIDS. AIDS is a disease ... Burkitt lymphoma. This is also known as small non-cleaved cell lymphoma. This is a very fast-growing lymphoma. ... One method of staging Burkitt lymphoma is the following:. *Stage I. The lymphoma is in only 1 place. Its either in a lymph ... AIDS-Related Lymphoma in Children. What is AIDS-related lymphoma in a child?. AIDS-related lymphoma is a type of cancer called ...
more infohttp://healthlibrary.cityofhope.org/Library/Encyclopedia/160,41

AIDS-Related Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Forrest HealthAIDS-Related Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Forrest Health

AIDS-related lymphoma is a disease in which malignant (cancer) cells form in the lymph system of patients who have acquired ... Burkitt or Burkitt-like lymphoma.. For more information about lymphoma or AIDS-related cancers, see the following PDQ summaries ... Non-Hodgkin lymphoma.. Both Hodgkin lymphoma and non-Hodgkin lymphoma may occur in patients with AIDS, but non-Hodgkin lymphoma ... When a person with AIDS has non-Hodgkin lymphoma, it is called AIDS-related lymphoma. When AIDS-related lymphoma occurs in the ...
more infohttps://www.forresthealth.org/health-library/healthwise-document-viewer/?id=ncicdr0000257993

AIDS-related lymphomaAIDS-related lymphoma

... are Burkitts lymphoma (BL). Primary central nervous system lymphoma (PCNSL) accounts for 10 to 15% of ARLs. Primary effusion ... primary effusion lymphoma, pyothorax-associated lymphoma, pulmonary involvement by leukemia or lymphoma, rare hematologic ... AIDS-related lymphoma What every physician needs to know about AIDS-related lymphoma:. HIV is associated with malignancy, as it ... What every physician needs to know about AIDS-related lymphoma: * Are you sure your patient has AIDS-related lymphoma? What ...
more infohttp://www.pulmonologyadvisor.com/hematology/aids-related-lymphoma/article/658417/

Burkitt Lymphoma Treatment Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2018-2026Burkitt Lymphoma Treatment Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2018-2026

The research report on burkitt lymphoma treatment market categorizes global market by therapy type (Chemotherapy, Targeted ... Burkitt lymphoma is a type of high-grade non-Hodgkin lymphoma (NHL). The World Health Organization has classified Burkitt ... Rising incidence HIV is expected to augment growth of the Burkitt lymphoma treatment market, as Burkitt lymphoma is an AIDS- ... Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults, especially with a ...
more infohttps://www.coherentmarketinsights.com/ongoing-insight/burkitt-lymphoma-treatment-market-1547

Burkitts lymphoma - WikipediaBurkitt's lymphoma - Wikipedia

Burkitts lymphoma. Hodgkins lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ... Since Burkitt lymphoma and other B-cell lymphomas are a clonal proliferative process, all tumor cells from one patient are ... Unique genetic alterations promote cell survival in Burkitt lymphoma, distinct from other types of lymphoma.[21] These TCF3 and ...
more infohttps://en.wikipedia.org/wiki/Burkitt%27s_lymphoma

Burkitt Lymphoma | Encyclopedia.comBurkitt Lymphoma | Encyclopedia.com

... is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B-cell lymphoma or small noncleaved cell lymphoma. ... Burkitts lymphoma. Definition. Burkitts lymphoma (BL) is a type of non-Hodgkins lymphoma (NHL) that is sometimes called a B- ... Non-Hodgkins lymphoma (NHL). -One of two major subdivisions of lymphomas. Burkitts lymphoma is a subcategory of NHL. ... Burkitts lymphoma was first described in 1957 by Denis Parsons Burkitt, an Irish surgeon. While this type of lymphoma is still ...
more infohttps://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/burkitt-lymphoma

Burkitt lymphoma: MedlinePlus Medical EncyclopediaBurkitt lymphoma: MedlinePlus Medical Encyclopedia

... is a very fast growing form of non-Hodgkin lymphoma. ... Burkitt lymphoma (BL) is a very fast growing form of non- ... B-cell lymphoma; High-grade B-cell lymphoma; Small noncleaved cell lymphoma ... Burkitts lymphoma and its mimics. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, eds. Hematopathology. ... Adult non-Hodgkin lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment- ...
more infohttps://medlineplus.gov/ency/article/001308.htm

How is Burkitt lymphoma diagnosed?How is Burkitt lymphoma diagnosed?

if burkitt lymphoma is suspected, all or part of an enlarged lymph node or other suspicious disease site will be biopsied. in a ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... Macmillan.org: "Burkitt lymphoma and Burkitt-like lymphoma." Merck Manual Home Edition: "Non-Hodgkin Lymphomas." Perkins, A. , ... How is Burkitt lymphoma diagnosed?. ANSWER If Burkitt lymphoma is suspected, all or part of an enlarged lymph node or other ...
more infohttps://www.webmd.com/cancer/lymphoma/qa/how-is-burkitt-lymphoma-diagnosed

Childhood Lymphoma Staging | Burkitt Lymphoma StagingChildhood Lymphoma Staging | Burkitt Lymphoma Staging

Learn how non-Hodgkin lymphoma in children and Burkitt lymphoma are staged from the cancer experts at the American Cancer ... Stages of Non-Hodgkin Lymphoma in Children. What is the stage of a lymphoma?. A lymphomas stage is the extent of the disease ... Stage II lymphomas are not in the chest, and one of the following applies:. *The lymphoma is a single tumor and is also in ... For stage III lymphomas, one of the following applies:. *The lymphoma started in the chest (usually in the thymus or lymph ...
more infohttps://www.cancer.org/cancer/childhood-non-hodgkin-lymphoma/detection-diagnosis-staging/staging.html

Histology of Burkitts lymphoma. | The BMJHistology of Burkitt's lymphoma. | The BMJ

Histology of Burkitts lymphoma.. Br Med J 1971; 1 doi: https://doi.org/10.1136/bmj.1.5750.669-a (Published 20 March 1971) Cite ...
more infohttp://www.bmj.com/content/1/5750/669.2

Burkitt Lymphoma: Pathogenesis and Immune EvasionBurkitt Lymphoma: Pathogenesis and Immune Evasion

Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. Although BL can be ... Burkitt Lymphoma: Pathogenesis and Immune Evasion. Jason M. God and Azizul Haque ... B-cell lymphomas arise at distinct stages of cellular development and maturation, potentially influencing antigen (Ag) ...
more infohttps://www.hindawi.com/journals/jo/2010/516047/abs/

Orbital Burkitts Lymphoma: An Aggressive PresentationOrbital Burkitt's Lymphoma: An Aggressive Presentation

D. Burkitt, "Burkitts lymphoma outside the known endemic areas of Africa and New Guinea," International Journal of Cancer, vol ... Orbital Burkitts Lymphoma: An Aggressive Presentation. Gian Paolo Giuliari,1,2,3 Ama Sadaka,4 Maria Angelica Cortez,1,3 and ... D. Burkitt and G. T. OConor, "Malignant lymphoma in African children. I. A clinical syndrome," Cancer, vol. 14, pp. 258-269, ... I. K. Ruf, P. W. Rhyne, H. Yang et al., "Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma ...
more infohttps://www.hindawi.com/journals/criopm/2012/354043/ref/

Epidemiologic Notes and Reports
Burkitts Lymphoma -- Winchester, VirginiaEpidemiologic Notes and Reports Burkitt's Lymphoma -- Winchester, Virginia

Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, Virginia Three cases of Burkitts lymphoma (BL) have occurred ... editorial note: Burkitts lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it ... Brubaker G, Geser A, Pike MC: Burkitts lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of ... Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of American Burkitts Lymphoma in neighbors. N Engl J Med 288: ...
more infohttps://www.cdc.gov/mmwr/preview/mmwrhtml/00048532.htm

Burkitt Lymphoma by Aislynn Kennedy on PreziBurkitt Lymphoma by Aislynn Kennedy on Prezi

Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
more infohttps://prezi.com/hxndj83_gjnc/burkitt-lymphoma/

Survival Rates for Childhood Non-Hodgkin & Burkitt LymphomaSurvival Rates for Childhood Non-Hodgkin & Burkitt Lymphoma

Learn about the survival rates of non-Hodgkin lymphoma cancer in children including lymphoblastic, Burkitt, and large cell ... Burkitt and Burkitt-like lymphoma Treatment of limited stage (stage I and II) Burkitt lymphomas is usually very successful, ... The long-term survival rate for children with more advanced (stage III or IV) Burkitt lymphoma ranges from about 80% to 90%. ... Large cell lymphomas The long-term survival rate is over 90% for limited stage (stage I and II) diffuse large B-cell lymphomas ...
more infohttps://www.cancer.org/cancer/childhood-non-hodgkin-lymphoma/detection-diagnosis-staging/survival-rates.html

Burkitts lymphomasBurkitt's lymphomas

Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult ... Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas. Burkitts lymphoma: single-centre experience with modified ... Overview of Burkitts Lymphoma. ABOUT Lymphomas:. Overview of genes and cancer. Lymphoma is a cancer. About Lymphoma - general ... Burkitt-like lymphoma of T-cell type ncbi.nlm.nih.gov The Burkitt-like lymphomas bloodjournal.hematologylibrary.org. Southwest ...
more infohttp://lymphomation.org/type-burkitts.htm

Burkitts Lymphoma | Definition of Burkitts Lymphoma by Merriam-WebsterBurkitt's Lymphoma | Definition of Burkitt's Lymphoma by Merriam-Webster

... a non-Hodgkins lymphoma of B cell origin that occurs especially in children of central Africa and is associated with Epstein- ... Comments on Burkitts lymphoma. What made you want to look up Burkitts lymphoma? Please tell us where you read or heard it ( ... Time Traveler for Burkitts lymphoma. The first known use of Burkitts lymphoma was in 1963. See more words from the same year ... History and Etymology for Burkitts lymphoma. Denis Parsons Burkitt †1993 British surgeon ...
more infohttps://www.merriam-webster.com/dictionary/Burkitt%27s%20lymphoma

Burkitts lymphoma dictionary definition | Burkitts lymphoma definedBurkitt's lymphoma dictionary definition | Burkitt's lymphoma defined

in children, in the jaw, eyes, and internal organs: it is associated with the Epstein-Barr virusOrigin of Burkitts ... Burkitts lymphoma definition: a cancer characterized by tumors containing lymphoid cells, occurring esp. ... Burkitts lymphoma. Bur·kitts lymphoma. a cancer characterized by tumors containing lymphoid cells, occurring esp. in children ... "Burkitt\s lymphoma." YourDictionary, n.d. Web. 19 January 2019. ,https://www.yourdictionary.com/burkitt-s-lymphoma,. ...
more infohttps://www.yourdictionary.com/burkitt-s-lymphoma

Treatments for childhood Burkitt lymphoma - Canadian Cancer SocietyTreatments for childhood Burkitt lymphoma - Canadian Cancer Society

Treatments for childhood Burkitt lymphoma are based on stage. The most common treatment used is chemotherapy. Learn about ... Treatments for childhood Burkitt lymphoma. The following are treatment options for childhood Burkitt lymphoma. The healthcare ... Treatments for recurrent childhood Burkitt lymphoma. Treatments for recurrent (relapsed) childhood Burkitt lymphoma may include ... Cancer information / Cancer types / Non-Hodgkin lymphoma - childhood / Treatment / Burkitt lymphoma Select the text below and ...
more infohttp://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma-childhood/treatment/burkitt-lymphoma/?region=ns

Burkitts lymphoma of the colonBurkitt's lymphoma of the colon

2006 issue concerning the molecular diagnosis of Burkitts lymphoma, almost half the patients with Burkitts lymphoma were ... Diagnosis of Burkitts lymphoma in due time: a practical approach. Cogliatti, S. B.; Novak, U.; Henz, S.; Schmid, U.; Möller, P ... Genomic Diagnosis of Burkitts Lymphoma. Lin, Bryan T. // New England Journal of Medicine;9/7/2006, Vol. 355 Issue 10, p1064 A ... Genomic Diagnosis of Burkitts Lymphoma. Dave, Sandeep S.; Staudt, Louis M. // New England Journal of Medicine;9/7/2006, Vol. ...
more infohttp://connection.ebscohost.com/c/abstracts/66954903/burkitts-lymphoma-colon

Medical Xpress - burkitt lymphomaMedical Xpress - burkitt lymphoma

Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
more infohttps://medicalxpress.com/tags/burkitt+lymphoma/sort/rank/1d/

Burkitt lymphoma - Renal and Urology NewsBurkitt lymphoma - Renal and Urology News

As such, Burkitt lymphoma accounts for 30% of pediatric lymphomas and less than 1% of lymphoma cases in adults. The disease ... Burkitt lymphoma. What every physician needs to know:. Burkitt Lymphoma is a rapidly progressive lymphoid malignancy requiring ... Other non-Hodgkin lymphoma (NHL) histologies need to be differentiated from Burkitt lymphoma. Diffuse large B-cell lymphoma ( ... Are you sure your patient has Burkitt lymphoma? What should you expect to find?. The endemic variant of Burkitt lymphoma ...
more infohttps://www.renalandurologynews.com/hematology/burkitt-lymphoma/article/597528/
  • High-resolution structural and functional genomic analysis of adult Burkitt lymphoma (BL) and high-grade B-cell lymphoma with BL gene signature (adult-molecularly defined BL [mBL]) revealed the MYCARF- p53 axis as the primary deregulated pathway. (elsevier.com)
  • These double-hit lymphomas may have arisen from a tumor precursor that acquired both BCL2 and MYC translocations and/or KMT2D(MLL2)mutation. (elsevier.com)
  • Burkitt lymphoma primarily affects African children, and malaria may make children more vulnerable. (morganadamsfoundation.org)
more