AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Burkitt LymphomaLymphomaLymphoma, B-CellLymphoma, Non-HodgkinLymphoma, Large B-Cell, DiffuseLymphoma, T-CellHerpesvirus 4, HumanLymphoma, FollicularLymphoma, AIDS-RelatedTranslocation, GeneticChromosomes, Human, 6-12 and XLymphoma, B-Cell, Marginal ZoneEpstein-Barr Virus Nuclear AntigensChromosomes, Human, 13-15Glutamate FormimidoyltransferaseGenes, mycProto-Oncogene Proteins c-mycB-LymphocytesEpstein-Barr Virus InfectionsLymphoma, Mantle-CellLymphoma, T-Cell, CutaneousHodgkin DiseaseLymphoma, T-Cell, PeripheralLymphoma, Large-Cell, AnaplasticChromosomes, Human, Pair 14VincristineTumor Cells, CulturedGerminal CenterOncogenesAntibodies, Monoclonal, Murine-DerivedCyclophosphamideIn Situ Hybridization, FluorescenceAntigens, CD20Chromosomes, Human, 1-3Genes, Immunoglobulin Heavy ChainCell Line, TumorImmunophenotypingImmunoglobulin Heavy ChainsCell LineSesquiterpenes, GuaianeLeukemia, B-CellDoxorubicinGene RearrangementSesquiterpenes, EudesmaneChromosomes, Human, Pair 8NeprilysinCytogeneticsAntineoplastic Combined Chemotherapy ProtocolsLymphoma, Large-Cell, ImmunoblasticViral Matrix ProteinsHLA-A11 AntigenGenes, mybImmunohistochemistryGene Expression Regulation, NeoplasticProto-Oncogene Proteins c-bcl-2Genes, bcl-2PlasmacytomaCytarabineBase SequenceApoptosisAntibodies, MonoclonalTanacetum partheniumFlow CytometryVirus LatencyAntigens, ViralPrednisoneInhibitor of Differentiation ProteinsLymphoproliferative DisordersDNA, NeoplasmGenes, ImmunoglobulinChromosome BandingKaryotypingTreatment OutcomeMethotrexateReceptors, Antigen, B-CellCell Transformation, ViralNeoplasm ProteinsAntineoplastic AgentsEtoposideMolecular Sequence DataProto-OncogenesLeukemia, LymphoidPrognosisLymphocytesRemission InductionLymphoma, Extranodal NK-T-CellCell Transformation, NeoplasticTumor Markers, BiologicalTranscription, GeneticCell Line, TransformedPolymerase Chain ReactionGene Expression Regulation, ViralDNA, ViralChaperonin Containing TCP-1BiopsyHybrid CellsVirus ActivationNational Cancer Institute (U.S.)
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.
Lymphoma, B-Cell
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Lymphoma, T-Cell
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Herpesvirus 4, Human
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Lymphoma, Follicular
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Lymphoma, AIDS-Related
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Translocation, Genetic
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
Chromosomes, Human, 6-12 and X
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
Lymphoma, B-Cell, Marginal Zone
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.
Epstein-Barr Virus Nuclear Antigens
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
Chromosomes, Human, 13-15
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
Glutamate Formimidoyltransferase
A PYRIDOXAL PHOSPHATE-containing enzyme that catalyzes the transfer of a formyl group from L-GLUTAMATE to N-formimidoyl-L-glutamate and TETRAHYDROFOLATE. This enzyme may also catalyze formyl transfer from 5-formyltetrahydrofolate to L-GLUTAMATE. This enzyme was formerly categorized as EC 2.1.2.6.
Genes, myc
Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.
Proto-Oncogene Proteins c-myc
Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
B-Lymphocytes
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Epstein-Barr Virus Infections
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Lymphoma, Mantle-Cell
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Lymphoma, T-Cell, Cutaneous
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Lymphoma, T-Cell, Peripheral
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
Lymphoma, Large-Cell, Anaplastic
A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.
Chromosomes, Human, Pair 14
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Vincristine
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Germinal Center
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
Oncogenes
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Antibodies, Monoclonal, Murine-Derived
Antibodies obtained from a single clone of cells grown in mice or rats.
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
In Situ Hybridization, Fluorescence
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Antigens, CD20
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
Chromosomes, Human, 1-3
The large, metacentric human chromosomes, called group A in the human chromosome classification. This group consists of chromosome pairs 1, 2, and 3.
Genes, Immunoglobulin Heavy Chain
Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Immunophenotyping
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Immunoglobulin Heavy Chains
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Sesquiterpenes, Guaiane
SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.
Leukemia, B-Cell
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
Doxorubicin
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Gene Rearrangement
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Sesquiterpenes, Eudesmane
SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.
Chromosomes, Human, Pair 8
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Neprilysin
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Cytogenetics
A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.
Antineoplastic Combined Chemotherapy Protocols
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Lymphoma, Large-Cell, Immunoblastic
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
Viral Matrix Proteins
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
HLA-A11 Antigen
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.
Genes, myb
Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Gene Expression Regulation, Neoplastic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Genes, bcl-2
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
Plasmacytoma
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Tanacetum parthenium
An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Virus Latency
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
Antigens, Viral
Substances elaborated by viruses that have antigenic activity.
Prednisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Inhibitor of Differentiation Proteins
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Lymphoproliferative Disorders
Disorders characterized by proliferation of lymphoid tissue, general or unspecified.
DNA, Neoplasm
DNA present in neoplastic tissue.
Genes, Immunoglobulin
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
Chromosome Banding
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Karyotyping
Mapping of the KARYOTYPE of a cell.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Methotrexate
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Receptors, Antigen, B-Cell
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proto-Oncogenes
Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
Prognosis
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Remission Induction
Therapeutic act or process that initiates a response to a complete or partial remission level.
Lymphoma, Extranodal NK-T-Cell
An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Cell Line, Transformed
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Gene Expression Regulation, Viral
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
DNA, Viral
Deoxyribonucleic acid that makes up the genetic material of viruses.
Chaperonin Containing TCP-1
A group II chaperonin found in eukaryotic CYTOSOL. It is comprised of eight subunits with each subunit encoded by a separate gene. This chaperonin is named after one of its subunits which is a T-COMPLEX REGION-encoded polypeptide.
Biopsy
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Hybrid Cells
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
Virus Activation
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
National Cancer Institute (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. (1/1897)

Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL) cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other EBV-positive BL cells express a restricted set of EBV gene products (type I latency) that are not known to overtly affect cell growth. Here we demonstrate that reestablishment of type I latency in EBV-negative Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resistance to apoptosis under growth-limiting conditions. The antiapoptotic effect of EBV was associated with a higher level of Bcl-2 expression and an EBV-dependent decrease in steady-state levels of c-MYC protein. Although the EBV EBNA-1 protein is expressed in all EBV-associated tumors and is reported to have oncogenic potential, enforced expression of EBNA-1 alone in EBV-negative Akata cells failed to restore tumorigenicity or EBV-dependent down-regulation of c-MYC. These data provide direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a novel model whereby a restricted latency program of EBV promotes B-cell survival, and thus virus persistence within an immune host, by selectively targeting the expression of c-MYC.  (+info)

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells. (2/1897)

CTCF is a transcriptional repressor of the c-myc gene. Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity. Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells. We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway. We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.  (+info)

Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. (3/1897)

Bruton's tyrosine kinase (Btk) has been shown to play a role in normal B-lymphocyte development. Defective expression of Btk leads to human and murine immunodeficiencies. However, the exact role of Btk in the cytoplasmic signal transduction in B cells is still unclear. This study represents a search for the substrate for Btk in vivo. We identified one of the major phosphoproteins associated with Btk in the preB cell line NALM6 as the Wiskott-Aldrich syndrome protein (WASP), the gene product responsible for Wiskott-Aldrich syndrome, which is another hereditary immunodeficiency with distinct abnormalities in hematopoietic cells. We demonstrated that WASP was transiently tyrosine-phosphorylated after B-cell antigen receptor cross-linking on B cells, suggesting that WASP is located downstream of cytoplasmic tyrosine kinases. An in vivo reconstitution system demonstrated that WASP is physically associated with Btk and can serve as the substrate for Btk. A protein binding assay suggested that the tyrosine-phosphorylation of WASP alters the association between WASP and a cellular protein. Furthermore, identification of the phosphorylation site of WASP in reconstituted cells allowed us to evaluate the catalytic specificity of Btk, the exact nature of which is still unknown.  (+info)

Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells. (4/1897)

In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-crossblocking pairs), polyclonal anti-mu Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fab', F(ab')2 and F(ab')3 derivatives from anti-Fc mu mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (C mu2-C mu4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-Fd mu, or C mu1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb.  (+info)

Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. (5/1897)

Ligation of CD40 on the surface of B cells induces multiple phenotypic effects, many of which are mimicked by the EBV latent membrane protein 1 (LMP1) through its interaction with downstream components of the CD40 signaling pathway. Because the effects of LMP1 have been most closely studied in human Burkitt Lymphoma (BL) cell lines retaining a tumor biopsy-like phenotype in vitro, we have examined the response of a panel of such lines to CD40 ligation. Two distinct patterns of response were observed that were unrelated to the surface level of CD40 or to the EBV genome status of the lines. Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition. Aggregation was seen at lower doses than those required to elicit the other effects. By contrast, low responder (LR) lines showed no detectable response to CD40 mAbs, while their responses to sCD40L were limited to activation of NF-kappa B and up-regulation of CD95 only. However, in transfection experiments, LMP1 uniformly induced the full spectrum of phenotypic effects in both HR and LR lines. We conclude that some BL cell lines show a highly restricted response to CD40 ligation but remain fully susceptible to LMP1.  (+info)

Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases. (6/1897)

Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)-related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans.  (+info)

Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo. (7/1897)

The consistent presence of EBV genomes in certain tumor types (in particular, AIDS-related central nervous system lymphomas and nasopharyngeal carcinomas) may allow novel, EBV-based targeting strategies. Tumors contain the latent (transforming) form of EBV infection. However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce lytic EBV infection, resulting in death of the host cell. We have constructed replication-deficient adenovirus vectors expressing the BZLF1 or BRLF1 immediate-early genes and examined their utility for killing latently infected lymphoma cells in vitro and in vivo. We show that both the BZLF1 and BRLF1 vectors efficiently induce lytic EBV infection in Jijoye cells (an EBV-positive Burkitt lymphoma cell line). Furthermore, lytic EBV infection converts the antiviral drug, ganciclovir (GCV), into a toxic (phosphorylated) form, which inhibits cellular as well as viral DNA polymerase. When Jijoye cells are infected with the BZLF1 or BRLF1 adenovirus vectors in the presence of GCV, viral reactivation is induced, but virus replication is inhibited (thus preventing the release of infectious EBV particles); yet cells are still efficiently killed. Finally, we demonstrate that the BZLF1 and BRLF1 adenovirus vectors induce lytic EBV infection when they are directly inoculated into Jijoye cell tumors grown in severe combined immunodeficiency mice. These results suggest that induction of lytic EBV infection in tumors, in combination with GCV, may be an effective strategy for treating EBV-associated malignancies.  (+info)

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma. (8/1897)

In Burkitt's lymphoma (BL) cells the proto-oncogene c-myc is juxtaposed to one of the immunoglobulin (Ig) loci on chromosomes 2, 14, or 22. The c-myc gene becomes transcriptionally activated as a consequence of the chromosomal translocation and shows preferential usage of promoter P1 over P2, a phenomenon referred to as promoter shift. In order to define the responsible regulatory elements within the Ig lambda locus, we studied the effect of the human Ig lambda enhancer (HuE lambda) on c-myc expression after stable transfection into BL cells. A 12 kb genomic fragment encompassing HuE lambda, but not HuE lambda alone, strongly activated c-myc expression and induced the promoter shift. To identify additional elements involved in c-myc deregulation, we mapped DNaseI hypersensitive sites within the 12 kb lambda fragment on the construct. Besides one hypersensitive site corresponding to HuE lambda, three additional sites were detected. Two of these elements displayed enhancer activity after transient transfection. The third element did not activate c-myc transcription, but was required for full c-myc activation and promoter shift. Deletion analyses of the c-myc promoter identified the immediate promoter region as sufficient for activation by the Ig lambda. locus, but also revealed that induction of the promoter shift requires additional upstream elements.  (+info)

Burkitt Lymphoma Archives | Morgan Adams FoundationBurkitt Lymphoma Archives | Morgan Adams Foundation
What is Burkitt Lymphoma?. Burkitt lymphoma is a form of non-Hodgkins lymphoma which is a type of cancer that starts in the b-cells. Burkitt lymphoma is one of the fastest growing tumors. Burkitt lymphoma attacks the immune system and is fatal if not treated in a timely manner. There are three types of Burkitts lymphoma endemic, sporadic, and immunodeficiency- associated.. What causes Burkitt lymphoma? Who is affected?. The exact cause of Burkitt lymphoma is unknown, but there are factors associated with the disease such as Epstein-Barr. Individuals who are immunosuppressed have a higher risk factor for Burkitt lymphoma. Burkitt lymphoma primarily affects African children, and malaria may make children more vulnerable.. What are the symptoms of Burkitt lymphoma?. There are many symptoms associated with Burkitt lymphoma, including:. ...
https://www.morganadamsfoundation.org/tumor-category/burkitt-lymphoma/
Burkitt-like lymphoma in an English child: Characterisation of tumour biopsy cells and of the derived tumour cell lineBurkitt-like lymphoma in an English child: Characterisation of tumour biopsy cells and of the derived tumour cell line
An eight year old English boy presented with an abdominal undifferentiated Burkitt-like lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African endemic Burkitts lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was ...
https://scholars.latrobe.edu.au/display/publication254511
Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and PathophysiologyBurkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology
Burkitt lymphoma (BL) (or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, was used to describe this disease in patients presenting with a soli...
https://emedicine.medscape.com/article/1447602-overview
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma | BMC Cancer | Full TextIntegrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma | BMC Cancer | Full Text
Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells. Using more sensitive and specific transcriptome deep sequencing, we compared previously published small miRNA and long mRNA of a set of GC B cells and eBL tumors. MiRWalk2.0 was used to identify the validated target genes for the deregulated miRNAs, which would be important for understanding the regulatory networks associated with eBL development. We found 211 differentially expressed
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3711-9
Burkitts lymphomasBurkitts lymphomas
Burkitt are highly aggressive lymphomas. As such, the goal of treatment is usually to cure the disease with aggressive therapy. From OncologyChannel: Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma. In children, most SNCLs are Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas. Burkitts lymphoma tends to occur most often in children and in adults with compromised immune systems. There are three distinct forms of this disease: endemic, sporadic, and immunodeficient.. ...
http://lymphomation.org/type-burkitts.htm
Raji membrane lysate (ab30126) | AbcamRaji membrane lysate (ab30126) | Abcam
Buy our Raji (human Burkitts lymphoma cell line) membrane lysate, tumor cell line. ab30126 has been validated in western blot. Abcam now offers…
http://www.abcam.com/raji-membrane-extract-lysate-ab30126.html
Raji lysate (ab30124) | AbcamRaji lysate (ab30124) | Abcam
Buy our Raji (human Burkitts lymphoma cell line) whole cell lysate, tumor cell line. ab30124 has been validated in western blot. Abcam now offers…
http://www.abcam.com/raji-whole-cell-lysate-ab30124.html
MAB6690 - R&D Systems IRAK2 antibody | AntibodypediaMAB6690 - R&D Systems IRAK2 antibody | Antibodypedia
Detection of Human IRAK2 by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line, Raji human Burkitts lymphoma cell line, K562 human chronic myelogenous leukemia cell line, and HeLa human cervical epithelial carcinoma cell line. PVDF Membrane was probed with 0.5 µg/mL of Human IRAK2 Monoclonal Antibody (Catalog # MAB6690) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for IRAK2 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 ...
https://www.antibodypedia.com/gene/4605/IRAK2/antibody/703033/MAB6690
Matthew D. Scharff, M.D. -- Research Interest | Department of Cell Biology | Albert Einstein College of Medicine
Our laboratory is studying how antibody-forming cells respond to antigen by undergoing somatic hypermutation and class switch recombination so that they can produce higher affinity antibodies with more useful effector functions. The molecular and biochemical mechanisms of antibody variable region hypermutation and class switch recombination is being studied in mice that have mutations in various repair proteins in collaboration with Dr. Winfried Edelmann. In order to examine detailed molecular mechanisms, we are also studying how mutation is targeted to antibody genes and some oncogenes in human Burkitts lymphoma cell lines which are undergoing variable region mutation in culture. These cell lines and genetically defective mice are being used to study the role of activation induced deaminase (AID), mismatch repair and error prone polymerases in the variable region hypermutation and isotype switching. The analysis of these events also involves the examination of AID activity biochemically and, ...
http://www.einstein.yu.edu/departments/cell-biology/cell-biology.aspx?id=23974
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells | Molecular Cancer | Full TextThe novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells | Molecular Cancer | Full Text
Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands (CCL19, CCL21, CXCL12 and CXCL13) by endothelial cells inside the lymph nodes facilitates the trans-endothelial migration (TEM) of these cells through high endothelial venules into the lymph node parenchyma. It is known that CXCR7, a second CXCL12 receptor, regulates TEM of CXCR4+CXCR7+ tumor cells towards a CXCL12 source. In this study, we set out to assess the potential stimulation by CXCL12 of tumor cell TEM towards other chemokines and whether CXCR7 might be able to regulate such effects. The human Burkitts lymphoma cell line NC-37, which expresses CXCR4, CXCR5, CXCR7 and CCR7, was selected as a model system. TEM of these cells through a human HUVEC endothelial cell monolayer was used as the main model system for these studies. Regulation of their TEM
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-73/figures/2
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells | Molecular Cancer | Full TextThe novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells | Molecular Cancer | Full Text
Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands (CCL19, CCL21, CXCL12 and CXCL13) by endothelial cells inside the lymph nodes facilitates the trans-endothelial migration (TEM) of these cells through high endothelial venules into the lymph node parenchyma. It is known that CXCR7, a second CXCL12 receptor, regulates TEM of CXCR4+CXCR7+ tumor cells towards a CXCL12 source. In this study, we set out to assess the potential stimulation by CXCL12 of tumor cell TEM towards other chemokines and whether CXCR7 might be able to regulate such effects. The human Burkitts lymphoma cell line NC-37, which expresses CXCR4, CXCR5, CXCR7 and CCR7, was selected as a model system. TEM of these cells through a human HUVEC endothelial cell monolayer was used as the main model system for these studies. Regulation of their TEM
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-73/email/correspondent/c1/new
Burkitt Lymphoma Therapeutics Market: Latest Trends, Demand and Analysis 2025 - Market ReportsBurkitt Lymphoma Therapeutics Market: Latest Trends, Demand and Analysis 2025 - Market Reports
In this new business intelligence Burkitt Lymphoma Therapeutics market report, PMR serves a platter of market forecast, structure, potential, and socioeconomic impacts associated with the global Burkitt Lymphoma Therapeutics market. With Porters Five Forces and DROT analyses, the research study incorporates a comprehensive evaluation of the positive and negative factors, as well as the opportunities regarding the Burkitt Lymphoma Therapeutics market.. With having published myriads of Burkitt Lymphoma Therapeutics market reports, PMR imparts its stalwartness to clients existing all over the globe. Our dedicated team of experts deliver reports with accurate data extracted from trusted sources. We ride the wave of digitalization - facilitate clients with the changing trends in various industries, regions and consumers. As customer satisfaction is our top priority, our analysts are available 24/7 to provide tailored business solutions to the clients.. Request Sample Report @ ...
https://nysenewstimes.com/burkitt-lymphoma-therapeutics-market-latest-trends-demand-and-analysis-2025/
Plus itPlus it
The nuclear enzyme poly(ADP-ribose) polymerase (PADPRP) is thought to play a role in DNA recombination, replication, and repair. In view of the implication of these processes in tumorigenesis, and based on preliminary evidence which indicated the presence of an extraneous polymorphic restriction fragment for murine PADPRP loci in strains of mice susceptible to plasmacytomas, we investigated correlations between the restriction fragment length polymorphism of the PADPRP gene(s) and human Burkitt lymphoma. No increase in the frequency of polymorphisms on chromosome 1 (containing the active gene) or on chromosome 14 (a pseudogene) was observed. However, restriction fragment length polymorphism analysis of PADPRP sequences on chromosome 13 (either a processed pseudogene or a gene with extensive identity to PADPRP) revealed that of 19 DNA samples derived from endemic Burkitt lymphoma all contained at least one copy of a rare allele (B). Simple two-allele (A/B) polymorphisms in this PADPRP-like locus ...
http://cancerres.aacrjournals.org/content/50/17/5406
CD19 monoclonal antibody, clone LT19 (Biotin) - (MAB4370) - Products - Abnova
Mouse monoclonal antibody raised against native CD19. Native purified CD19 from Daudi human Burkitt lymphoma cell line. (MAB4370) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=MAB4370
Histone deacetylase 6 activity is critical for the metastasis of Burkitts lymphoma cells | Cancer Cell International | Full...Histone deacetylase 6 activity is critical for the metastasis of Burkitts lymphoma cells | Cancer Cell International | Full...
Burkitts lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitts lymphoma is poor. Here we sought to identify a role of histone deacetylase 6 (HDAC6) in the metastasis of Burkitts lymphoma cells. Burkitts lymphoma cells were pharmacologically treated with niltubacin, tubacin or sodium butyrate (NaB) or transfected with siRNAs to knock down the expression of HDAC6. Cell migration and invasion ability were measured by transwell assay, and cell cycle progression was analyzed by flow cytometry. Cell adhesion and proliferation was determined by CellTiter-Glo luminescent cell viability assay kit. Cell morphological alteration and microtubule stability were analyzed by immunofluorescence staining. Effect of niltubacin, tubacin and NaB on acetylated tubulin and siRNA efficacy were measured by western blotting. Suppression of histone deacetylase 6 activity significantly compromised the
https://cancerci.biomedcentral.com/articles/10.1186/s12935-014-0139-z/figures/4
Quantitative profiling of housekeeping and Epstein-Barr virus gene transcription in Burkitt lymphoma cell lines using an...Quantitative profiling of housekeeping and Epstein-Barr virus gene transcription in Burkitt lymphoma cell lines using an...
BURKITT-LYMPHOM (PATHOLOGIE); ZELLLINIEN + ZELLLINIENISOLIERUNG (CYTOLOGISCHE METHODEN); EPSTEIN-BARR-VIRUS (VIROLOGIE); TRANSKRIPTION (MOLEKULARE GENETIK); DNA-MIKROARRAY TECHNOLOGIE; BURKITT LYMPHOMA (PATHOLOGY); CELL LINES + CELL LINE ISOLATION (CYTOLOGICAL METHODS); EPSTEIN-BARR-VIRUS (VIROLOGY); TRANSCRIPTION (MOLECULAR GENETICS); DNA ...
https://www.research-collection.ethz.ch/handle/20.500.11850/149416
Correction: Exosomes Derived from Burkitts Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch...Correction: Exosomes Derived from Burkitts Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch...
Gutzeit, C., N. Nagy, M. Gentile, K. Lyberg, J. Gumz, H. Vallhov, I. Puga, E. Klein, S. Gabrielsson, A. Cerutti, and A. Scheynius. 2014. Exosomes derived from Burkitts lymphoma cell lines induce proliferation, differentiation, and class-switch recombination in B cells. J. Immunol. 192: 5852-5862.. In the published version of Fig. 6A, the FACS dotplot shown for the stimulation of DG75-COex at 25 μg in the presence of IL-21 was inadvertently duplicated from the 5 μg/IL-21 panel. The indicated frequency of 5% of CD38highCD20low B cells, however, is correct. This correct value of 5% was used in Fig. 6B, so the error in Fig. 6A did not influence the interpretation of the results and conclusions of this work. Fig. 6A has now been corrected with the correct dotplot for stimulation of DG75-COex at 25 μg in the presence of IL-21. The corrected version of Fig. 6 is shown below. The figure legend was correct as published and is shown below for reference. Fig. 6 has also been corrected in the online ...
https://www.jimmunol.org/content/203/3/769
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA methylation and diminished PUMA expression, which can be reactivated following inhibition of DNA methyltransferases. These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics.. ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:209194
Burkitt lymphoma facts, information, pictures | Encyclopedia.com articles about Burkitt lymphoma
Get information, facts, and pictures about Burkitt lymphoma at Encyclopedia.com. Make research projects and school reports about Burkitt lymphoma easy with credible articles from our FREE, online encyclopedia and dictionary.
http://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/burkitt-lymphoma
CyFlow™ CD29 Purified | Expanded Antibody Search | Antibodies | Reagents | Sysmex Flow Cytometry EuropeCyFlow™ CD29 Purified | Expanded Antibody Search | Antibodies | Reagents | Sysmex Flow Cytometry Europe
HLDA WorkshopHLDA VI-WS Code AS A048 Concentration Unitmg/mLConcentration1Quantity0.1 mgVolume0.1ImmunogenRaji cells: human Burkitts lymphoma cell...
https://eu.sysmex-flowcytometry.com/antibodies/expanded-antibody-search/1869/cyflow-cd29-purified
Cancers | Free Full-Text | The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell GrowthCancers | Free Full-Text | The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth
The expression of several microRNAs (miRNAs) is known to be changed in Burkitt lymphoma (BL), compared to its normal counterparts. Although for some miRNAs, a role in BL was demonstrated, for most of them, their function is unclear. In this study, we aimed to identify miRNAs that control BL cell growth. Two BL cell lines were infected with lentiviral pools containing either 58 miRNA inhibitors or 44 miRNA overexpression constructs. Eighteen constructs showed significant changes in abundance over time, indicating that they affected BL growth. The screening results were validated by individual green fluorescent protein (GFP) growth competition assays for fifteen of the eighteen constructs. For functional follow-up studies, we focused on miR-26b-5p, whose overexpression inhibited BL cell growth. Argonaute 2 RNA immunoprecipitation (Ago2-IP) in two BL cell lines revealed 47 potential target genes of miR-26b-5p. Overlapping the list of putative targets with genes showing a growth repression phenotype in a
https://www.mdpi.com/2072-6694/12/6/1464
Burkitts tumor synonyms, Burkitts tumor antonyms - FreeThesaurus.comBurkitts tumor synonyms, Burkitts tumor antonyms - FreeThesaurus.com
Synonyms for Burkitt's tumor in Free Thesaurus. Antonyms for Burkitt's tumor. 2 synonyms for tumor: neoplasm, tumour. What are synonyms for Burkitt's tumor?
https://www.freethesaurus.com/Burkitt%27s+tumor
Burkitt - WikipediaBurkitt - Wikipedia
Burkitt is an ancient name of Anglo-Saxon origin, and may refer to: Denis Parsons Burkitt, surgeon Francis Crawford Burkitt, British theologian Jack Burkitt, English footballer James Parsons Burkitt, ornithologist M. C. Burkitt, British palaeohistorian William Burkitt, biblical expositor and vicar in Dedham, Essex, England Judge Sir William Burkitt Burkitts lymphoma Burkitt name origin Alternative origin of Burkitt ...
https://en.wikipedia.org/wiki/Burkitt
Role of the p53 Tumor Suppressor Gene in the Tumorigenicity of Burkitts Lymphoma Cells | Cancer ResearchRole of the p53 Tumor Suppressor Gene in the Tumorigenicity of Burkitts Lymphoma Cells | Cancer Research
Burkitts lymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. We examined the potential role of the p53 gene in BL tumorigenicity using an in vitro assay that measures p53-dependent cell cycle arrest in the G1 phase of the cell cycle and an in vivo athymic murine model that detects differences in the tumorigenicity of BL cell lines. A highly significant inverse correlation was found between the ability of BL cells to arrest in G1 after irradiation and their tumorigenicity in athymic mice, consistent with the notion that loss of p53 function is associated with increased tumorigenicity. Inactivation of wild-type (wt) p53 function by expression of the human papillomavirus E6 protein in the AG876V BL cell line, which carries both wt and mutant p53 proteins, rendered the cell line significantly more tumorigenic in athymic mice. Transfection of the wt p53 gene into the p53 mutant and highly tumorigenic BL-41 cell line ...
https://cancerres.aacrjournals.org/content/57/12/2508?ijkey=12dc957c4e3ea1cf7ddf77c2dc3e98ea07b8c7f0&keytype2=tf_ipsecsha
CyFlow™ CD19 PE-Cy7 | Expanded Antibody Search | Antibodies | Reagents | Sysmex Belgium Flow CytometryCyFlow™ CD19 PE-Cy7 | Expanded Antibody Search | Antibodies | Reagents | Sysmex Belgium Flow Cytometry
HLDA WorkshopHLDA 10Quantity100 testsVolume0.4ImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane glycopro...
https://be.sysmex-flowcytometry.com/reagents/antibodies/expanded-antibody-search/1758/cyflow-cd19-pe-cy7
CyFlow™ CD19 PE | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry CanadaCyFlow™ CD19 PE | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry Canada
HLDA WorkshopHCDM/HLDA 10Quantity100 testsVolume2.0 mLImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane gl…
https://ca.sysmex-flowcytometry.com/reagents/expanded-antibody-search/1797/cyflow-cd19-pe
CyFlow™ CD19 APC | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry CanadaCyFlow™ CD19 APC | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry Canada
HLDA WorkshopHCDM/HLDA 10Quantity100 testsVolume1.0 mLImmunogenDaudi human Burkitt lymphoma cell lineBackground InformationCD19 is a transmembrane gl…
https://ca.sysmex-flowcytometry.com/reagents/expanded-antibody-search/1801/cyflow-cd19-apc
Dr. Lisa Roth and the Treatment of Burkitt Lymphoma - New Developments in LymphomaDr. Lisa Roth and the Treatment of Burkitt Lymphoma - New Developments in Lymphoma
The Meyer Cancer Center recently profiled Dr. Lisa Roth and the far-reaching impact of her work in finding new targeted therapies to treat young patients with Burkitt lymphoma. Burkitts is an aggressive form of non-Hodgkin lymphoma that is often fatal. Finding alternative therapy options is important because, As many as 85 percent of children with Burkitt lymphoma respond…
https://cornell-lymphoma.com/2015/12/02/dr-lisa-roth-and-the-treatment-of-burkitt-lymphoma/
Prestren | Burkitts lymphoma - Prestren
Burkitts lymphoma is a sort of aggressive B-cell lymphoma. This condition is most usually observed in youngsters and isolated into three types:. - Endemic - this is generally seen in children living in Africa. Usually, this kind of Burkitts lymphoma affects the facial bones such as the jaw, the intestines such as the distal ileum and cecum. Other stomach parts such as the ovaries and kidneys can also be affected.. - Sporadic/Non-African - found outside of Africa and affects the same parts as that of the endemic mixed bag.. - Immunodeficiency associated - this kind of Burkitts lymphoma is usually seen in HIV patients or patients taking insusceptible suppressive drugs.. Causes. Alongside the stated associated factors, Burkitts lymphoma is exceptionally joined with Epstein-Barr virus and jungle fever. The virus creates a change inside the B-cells, a kind of lymphocyte found in the safe system. Exposure to jungle fever weakens the cells resistance to the virus effects, making it one of the ...
http://www.prestren.com/burkitts-lymphoma/
Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes<...
TY - JOUR. T1 - Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes. AU - Piccaluga, Pier Paolo. AU - De Falco, Giulia. AU - Kustagi, Manjunath. AU - Gazzola, Anna. AU - Agostinelli, Claudio. AU - Tripodo, Claudio. AU - Leucci, Eleonora. AU - Onnis, Anna. AU - Astolfi, Annalisa. AU - Sapienza, Maria Rosaria. AU - Bellan, Cristiana. AU - Lazzi, Stefano. AU - Tumwine, Lynnette. AU - Mawanda, Michael. AU - Ogwang, Martin. AU - Calbi, Valeria. AU - Formica, Serena. AU - Califano, Andrea. AU - Pileri, Stefano A.. AU - Leoncini, Lorenzo. PY - 2011/3/31. Y1 - 2011/3/31. N2 - Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a unique molecular entity, distinct from other B-cell malignancies. Indeed, by ...
https://moh-it.pure.elsevier.com/en/publications/gene-expression-analysis-uncovers-similarity-and-differences-amon
glossary:burkitt s lymphoma
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
http://m.www.lymphedemapeople.com/wiki/doku.php?id=glossary:burkitt_s_lymphoma
glossary:burkitt s lymphomaglossary:burkitt s lymphoma
Burkitts Lymphoma n. (Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus. From MedTerms: A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system. Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation, usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate ...
http://t.lymphedemapeople.com/wiki/doku.php?id=glossary:burkitt_s_lymphoma
Burkitt lymphoma : epidemiological features and survival in a South African centreBurkitt lymphoma : epidemiological features and survival in a South African centre
Background: The epidemiology of Burkitt Lymphoma (BL) shows that the endemic type is mainly confined to equatorial Africa and has a very close association with the Epstein-Barr virus (EBV), while the sporadic variant shows only a 20% association with EBV and is seen mainly in Europe and North America. An immunodeficent form of BL has been described more recently. This study aimed to describe the epidemiological characteristics and survival of children presenting with BL to Tygerberg Hospital, Cape Town, in South Africa. Methods: A retrospective, descriptive study reviewed all pediatric cases of Burkitt lymphoma at Tygerberg Hospital Oncology Unit between 1 January 1995 and 31 December 2010. The following data were analysed: age at diagnosis, gender, anatomic site, race, socio-economic demographic (rural vs. urban), treatment protocol, side effects, viral characteristics and survival. All cases were confirmed by histology and reviewed by a tumour board. Results: A total of 51 patients with ...
https://scholar.sun.ac.za/handle/10019.1/95511
Burkitt lymphoma - Canadian Cancer SocietyBurkitt lymphoma - Canadian Cancer Society
Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn about Burkitt lymphoma.
https://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/burkitt-lymphoma/?region=on
Burkitt lymphoma - Canadian Cancer SocietyBurkitt lymphoma - Canadian Cancer Society
Burkitt lymphoma occurs most often in children and young adults. Most people are infected with the Epstein-Barr virus. Learn about Burkitt lymphoma.
https://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/more-types-of-nhl/burkitt-lymphoma/?region=nu
Long term survival of children with burkitt lymphoma in Malawi after cyclophosphamide monotherapyLong term survival of children with burkitt lymphoma in Malawi after cyclophosphamide monotherapy
Background. Between 1991 and 1997, limited funding at times restricted available treatment for children with Burkitt lymphoma (BL) to cyclophosphamide (CPM) monotherapy at Lilongwe Central Hospital, Malawi. Our objective was to assess long-term survival in Malawian children with Burkitt lymphoma (BL) who had received one or more treatments with intravenous CPM at 40 mg/kg/dose at 14-day intervals. Procedure and Results. The study population consisted of 92 children in whom BL had been confirmed on fine needle aspirates (FNA), a home address had been documented on discharge from hospital, and the treatment records could be verified. Only the clinical site(s) of disease had been recorded. The M:F ratio was 1.4 and median age 8 years. A clinical officer on motorcycle attempted to locate the given addresses and interview parents or other sources. In 19 patients, the address was incorrect. Of 73 evaluable patients, 40 children are alive at a mean follow-up time of 59 (range: 29-104) months. The ...
http://scholar.sun.ac.za/handle/10019.1/14175
Adult Burkitt Lymphoma: An Unusual Presentation | International Journal Of PathologyAdult Burkitt Lymphoma: An Unusual Presentation | International Journal Of Pathology
Shahzad Ali Jiskani, Asfa Zawar and Lubna Naseem. Department of Pathology, Pakistan Institute of Medical Sciences, Islamabad. Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad. Abstract: Burkitt lymphoma is a disease of young population; especially children. It rarely occurs and presented in elderly group. World Heal Organization (WHO) divided Burkitt lymphoma in endemic, sporadic and immunodeficiency - associated. The non - endemic variant occur in children with abdominal involvement. We report a sporadic case presented at the age of 61 years old male with irregular thickening or parietal peritoneum and omentum without involving any lymph nodes. ...
http://jpathology.com/adult-burkitt-lymphoma-an-unusual-presentation/
Reports on Cure 250 Children with Burkitt Lymphoma in Africa - GlobalGivingReports on Cure 250 Children with Burkitt Lymphoma in Africa - GlobalGiving
Ruth was 9 years old when she first came to St Marys Hospital Lacor in Gulu. She is from a village in Lira, the district that borders Gulu in northern Uganda. Her father brought her to St Marys in June 2019 after she experienced a one-month history of progressive and painful abdominal swelling. When she was admitted to our hospital, Ruth was quite ill. Her nutritional status was very poor and she had severe wasting. Upon examination, she had a grossly distended abdomen and an ill-defined mass that was palpable and very large. She underwent blood work, a chest x-ray and an ultrasound of her abdomen. The ultrasound revealed that she had multiple tumors in her liver, a separate large mass within her abdominal cavity as well as fluid in the abdomen. A biopsy of the large abdominal mass was performed which confirmed that she had Burkitt lymphoma.. Ruth required supportive care, including nutritional support, and was started on first-line (FL) chemotherapy for Burkitt lymphoma that consisted of ...
https://www.globalgiving.org/projects/cure-250-children-with-burkitt-lymphoma-in-africa/reports/?subid=142714
Plus itPlus it
Indeed, infection by Helicobacter pylori (H. pylori) has been recognized as a critical driver of mucosa-associated lymphoid tissue B-cell lymphoma, which is often reversible by antibiotic therapy. Likewise, chronic B-cell activation in the context of hepatitis C virus (HCV) infection was identified as a causative agent in the etiology of HCV-associated diffuse large B-cell lymphomas. Key evidence for this concept comes from a recent study on the role of Plasmodium falciparum (P. falciparum) in the etiology of endemic Burkitt lymphoma (5). In a genetic mouse model for chronic recurrent malaria infection, this study demonstrated that chronic B-cell activation in this model causes aberrant activation of AID and AID-mediated genomic instability leading to B-cell lymphoma. Of note, development of B-cell lymphoma in this model was critically dependent on protracted AID activity (somatic hypermutation and class-switch recombination) in the presence of plasmodium infection.. Initial genetic lesions ...
https://cancerdiscovery.aacrjournals.org/content/5/12/1244
Mechanism of cell death in Burkitt lymphomasMechanism of cell death in Burkitt lymphomas
Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). To elucidate molecular mechanisms regulating the development of apoptosis resistance, a panel of 15 BL cell lines was investigated for apoptosis induction upon treatment with microtubule inhibitors taxol, nocodazole and vincristine. Significant differences were observed in the extent of apoptosis induction among BL cell lines examined. Interestingly, cell lines exhibiting resistance to taxol- or nocodazole-induced apoptosis, showed development of polyploidy (,4N) and vice versa, displaying an inverse relationship between apoptosis and polyploidy induction. Further, in sensitive cell lines taxol-induced apoptosis was accompanied by caspase activation, Bid cleavage and Mcl-1 down-regulation. In contrast, most apoptosis resistant cell lines exhibited a loss of Bax and Bak expression and showed prolonged mitotic arrest with ,4N DNA content upon treatment. To gain mechanistic ...
https://edoc.hu-berlin.de/handle/18452/16738
Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc...Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc...
In Burkitt lymphoma the c-myc gene, the cellular homologue of the viral oncogene v-myc, has been implicated in the aetiology of this human B-cell malignancy. Burkitt lymphoma cells possess specific chromosomal rearrangements involving the region proximal to the c-myc gene and one of the three human immunoglobulin loci. The nature of the effect exerted by the immunoglobulin loci on the translocated c-myc gene is controversial: whereas some reports have suggested c-myc transcription is elevated in Burkitt lymphoma cells, others have suggested the level of transcription is unaffected by the translation. Recently, transcription enhancer elements have been identified in the intron between the JH and C mu segments of the heavy-chain immunoglobulin gene in mice. If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. We report here the identification of an enhancer element adjacent to the human C mu
https://www.rdm.ox.ac.uk/publications/601894
Epstein-Barr virus provides a survival factor to Burkitts lymphomas. - Semantic ScholarEpstein-Barr virus provides a survival factor to Burkitts lymphomas. - Semantic Scholar
Epstein-Barr virus (EBV) has been causally associated with at least five human malignancies. The exact contributions made by EBV to these cancers remain unknown. We demonstrate that one viral protein found in all EBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitts lymphoma. Inhibition of EBNA-1 decreases survival of these tumor cells by inducing apoptosis. Expression of EBNA-1 in uninfected cells also can inhibit apoptosis induced by expression of p53 in the absence of the EBV genome. Our findings demonstrate that EBNA-1 is critical for the continued survival of EBV-associated Burkitts lymphoma, and, by extension, for the other B cell tumors with which EBV is associated. Efficient inhibitors of EBNA-1s functions would likely prove useful in the therapy of EBV-associated malignancies.
https://www.semanticscholar.org/paper/Epstein-Barr-virus-provides-a-survival-factor-to-B-Kennedy-Komano/9f65b8807508bd9fb0780843b898d3da02b9847a
Staff Profile - Northern Institute for Cancer Research - Newcastle UniversityStaff Profile - Northern Institute for Cancer Research - Newcastle University
Zhou P, Newman AM, Van Noorden S, Banda K, Chagaluka G, Lampert I, Erhorn A, Bacon C, Bailey S, Molyneux E, Rand V. Investigation of prognostic markers in endemic Burkitt lymphoma. In: Fifth International Symposium on Childhood Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell Publishing Ltd ...
http://www.ncl.ac.uk/nicr/staff/profile/peixunzhou.html
MINCR is a MYC-induced lncRNA able to modulate MYCs transcriptional network in Burkitt lymphoma cells - Kielprints
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression. We identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt lymphoma and regulated in the same direction by MYC in the model cell lines. Among them, we focused on a lncRNA that we named MYC-induced long noncoding RNA (MINCR), showing a strong correlation with MYC expression in MYC-positive lymphomas. To understand its cellular role, we performed RNAi and found that MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes ...
http://eprints.uni-kiel.de/32455/
Center-Authored Papers | Shared Resources | Fred Hutchinson Cancer Research CenterCenter-Authored Papers | Shared Resources | Fred Hutchinson Cancer Research Center
Buckle GC, Collins JP, Sumba PO, Nakalema B, Omenah D, Stiffler K, Casper C, Otieno JA, Orem J, Moormann AM. 2013. Factors influencing time to diagnosis and initiation of treatment of endemic Burkitt Lymphoma among children in Uganda and western Kenya: a cross-sectional survey.. Infectious agents and cancer. 8(1):36. Abstract ...
https://sharedresources.fredhutch.org/publications/search/author/30280?sort=title&order=desc
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitts lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:156375
A carbohydrate-binding protein with a SUEL-type lectin domain promotes investigation of minimally invasive therapy by the...
SAL is a Gb3 (Galα1-4Galβ1-4Glc)-binding lectin with three SUEL-type lectin domains which was purified from catfish eggs. The lectin depleted expression of mRNA coding multidrug resistant protein, MRP1, time- and dose-dependently through binding with Gb3 glycosphingolipid which is highly expressed on human Burkitts lymphoma Raji cells. This interaction inhibited the excretion of chemotherapy drugs. The administration of vincristine could effectively killed Raji cells even at l/10 lower concentration than the lethal-doses, if co-treatment with SAL was conducted. The Japanese Association for Marine Biology (JAMBIO) in MEXT Japan identified this research as a leading edge topic as part of their 2012 research activities reporting. These results were possible through the work of Assist. Profs. Yuki Fujii (Nagasaki International University and adjunct researcher of Yokonama City University) and Shigeki Sugawara (Tohoku Pharmaceutical University), Assoc. Prof. Sarkar M. Abe Kawsar (University of ...
https://www.yokohama-cu.ac.jp/en/20120710-a-carbohydrate-binding-protein-with-a-suel-type-lectin-domain-promotes-investigation-of-minimally-invasive-therapy-by-the-depletion-of-gene-expression-coding-a-multidrug-resistant-transporter/
Which pro-survival BCL-2 family member should be targeted for the treatment of which cancer? - NCRI Cancer Conference abstracts
Impaired apoptosis is considered a prerequisite for the development of most, if not all, cancers, but the mechanisms that guarantee sustained survival of most cancer cells remain unknown. Members of the BCL-2 family of proteins are key regulators of apoptosis and include proteins essential for cell survival and those required to initiate cell death. Studies with transgenic mice have shown that over-expression of BCL-2 or related pro-survival family proteins, such as BCL-XL or MCL-1, can promote tumorigenesis, particularly in conjunction with mutations that deregulate cell cycle control, such as deregulated c-MYC expression. It is, however, not known whether expression of pro-survival BCL-2 family members under endogenous control is required to maintain survival of cells undergoing neoplastic transformation. Using Eµ-Myc transgenic mice, a well-characterized model of human Burkitts lymphoma, and other murine cancer models, we investigated the role of BCL-2 pro-survival proteins when expressed ...
https://abstracts.ncri.org.uk/abstract/which-pro-survival-bcl-2-family-member-should-be-targeted-for-the-treatment-of-which-cancer/
Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitts lymphoma cell line by a monoclonal antibody against a...Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitts lymphoma cell line by a monoclonal antibody against a...
In raising murine hybridoma antibodies against Epstein-Barr virus (EBV)-induced membrane antigens (MA), we found one antibody that blocked the release of infectious EBV from cultured P3HR-1 cells. This monoclonal antibody (mAb) recognized a 200 kD, phosphonoacetic acid-sensitive (late) MA, and did not directly neutralize virus without complement. When this mAb was added to 33 degrees C-cultured, spontaneously EBV-producing P3HR-1 cells, the intracellular expression of viral capsid antigen and infectious virus was not inhibited, but the appearance of infectious virus in the culture medium was significantly reduced. The duration of this suppression was dependent upon the concentration of the mAb, an effect being observed to a 1:4 X 10(5) titer of the ascites mAb preparation. A more acute effect of suppression of EBV release was observed in a second model of 12-o-tetradecanoyl phorbol-13-acetate and n-butyrate induction of EBV in 37 degrees C-cultured P3HR-1 cells. Again, intracellular infectious ...
http://jem.rupress.org/content/161/5/1097
13. Aggressive non-Hodgkins lymphomas - greek.doctor13. Aggressive non-Hodgkins lymphomas - greek.doctor
Endemic Burkitt is highly associated with EBV infection. , 30% of sporadic Burkitt lymphomas are EBV positive.. HIV-associated Burkitt is associated with HIV or other causes of immunodeficiency.. Epidemiology:. Endemic Burkitt lymphoma is endemic to equatorial Africa and South America. The sporadic and endemic types are more common in children while the HIV-associated type is more common in adults.. Clinical features:. Sporadic Burkitt often presents as an abdominal mass. It can be a cause for ileus. Endemic Burkitt usually presents as a mass in the maxilla or mandibula.. Pathology:. The tumor cells have very high rate of proliferation, and apoptosis is widespread. Tingible body macrophages phagocytose the apoptotic bodies, which causes the starry sky pattern on histology.. Treatment:. Burkitt tumours are highly chemosensitive. Patients with large tumours are at increased risk for tumor lysis syndrome.. ...
https://greek.doctor/haematology/13-aggressive-non-hodgkins-lymphomas/
Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: Genomic features and potential therapeutic targets<...
TY - JOUR. T1 - Adult high-grade B-cell lymphoma with Burkitt lymphoma signature. T2 - Genomic features and potential therapeutic targets. AU - Bouska, Alyssa. AU - Bi, Chengfeng. AU - Lone, Waseem. AU - Zhang, Weiwei. AU - Kedwaii, Ambreen. AU - Heavican, Tayla. AU - Lachel, Cynthia M.. AU - Yu, Jiayu. AU - Ferro, Roberto. AU - Eldorghamy, Nanees. AU - Greiner, Timothy Charles. AU - Vose, Julie Marie. AU - Weisenburger, Dennis D.. AU - Gascoyne, Randy D.. AU - Rosenwald, Andreas. AU - Ott, German. AU - Campo, Elias. AU - Rimsza, Lisa M.. AU - Jaffe, Elaine S.. AU - Braziel, Rita M.. AU - Siebert, Reiner. AU - Miles, Rodney R.. AU - Dave, Sandeep. AU - Reddy, Anupama. AU - Delabie, Jan. AU - Staudt, Louis M.. AU - Song, Joo Y.. AU - McKeithan, Timothy W.. AU - Fu, Kai. AU - Green, Michael. AU - Chan, Wing C.. AU - Iqbal, Javeed. PY - 2017/10/19. Y1 - 2017/10/19. N2 - The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma (BL) are highly aggressivelymphomas with ...
https://nebraska.pure.elsevier.com/en/publications/adult-high-grade-b-cell-lymphoma-with-burkitt-lymphoma-signature-
Epstein-Barr Virus Capsid Antigen (VCA) IgM ELISA Kit (CE)
The Epstein-Barr Virus Capsid Antigen (VCA) IgM ELISA Kit is intended for the measurement of IgM antibodies to Epstein-Barr Virus Capsid Antigen (VCA) in a sample. This kit utilizes Epstein-Barr VCA antigen (P3H3 cell extract, cultured in human Burkitt lymphoma cells).
https://cn.mpbio.com/07i532202-epstein-barr-virus-capsid-antigen-vca-igm-elisa-kit
Paravertebral Burkitts Lymphoma in a Child: An Unusual Presentation - Hoyoux ClaireParavertebral Burkitts Lymphoma in a Child: An Unusual Presentation - Hoyoux Claire
en] Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitts lymphoma. This is a rare location of sporadic Burkitts lymphoma with neurologic syndrome as first symptoms ...
http://orbi.ulg.ac.be/handle/2268/199169
Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: A study using electron microscopy and DNA gel...
Mild hyperthermia is known to enhance apoptosis in a range of normal and neoplastic cell populations. Studies of tumours previously shown to respond to heating in this manner might be expected to provide insights not only into the mechanism of hyperthermic cell killing, but also into the apoptotic process in general. In the present study, cell death induced by 43°C heating for 30 min in two human Burkitts lymphoma lines, BM 13674 and WW1, and in murine mastocytoma P‐815 × 2·1 was found to be exclusively apoptotic in type, identification being based on light and electron microscopic appearances and on the presence of internucleosomal cleavage of DNA into fragments that are multiples of 180-200 base pairs, which was demonstrated by agarose gel electrophoresis. The heat‐induced apoptosis was prevented by the presence of zinc sulphate, an inhibitor of the endonuclease considered to be responsible for the DNA cleavage, but was not suppressed by the protein synthesis inhibitor cycloheximide. ...
https://espace.library.uq.edu.au/view/UQ:403689
OpenEmory | Search ResultsOpenEmory | Search Results
Piperlongumine (PL), a pepper plant alkaloid from Piper longum, kills solid tumor cells in a highly selective, potent fashion. To evaluate whether PL may have similar effects on malignant blood cells, we determined the efficacy with which PL inhibits the B-lymphocyte derived neoplasm, Burkitt lymphoma (BL). Low micromolar concentrations of PL (IC50=2.8μM×8.5μM) curbed growth and survival of two EBV+ BL cell lines (Daudi, Raji) and two EBV BL cell lines (Ramos, DG-75), but left normal peripheral blood B-lymphocytes unharmed. PL-dependent cytotoxicity was effected in part by reduced NF-κB and MYC activity, with the former being caused by inhibition of IκBα degradation, nuclear translocation of p65, and binding of NF-κB dimers to cognate DNA sequences in gene promoters. In 4 of 4 BL cell lines, the NF-κB/MYC-regulated cellular target genes, E2F1 and MYB, were down regulated, while the stress sensor gene, GADD45B, was up regulated. The EBV-encoded oncogene, LMP-1, was suppressed in Daudi and ...
https://open.library.emory.edu/publications/search/?keywords=gene&keywords=b&subject=Health+Sciences%2C+Pharmacology&keywords=c
Malaria and susceptibility to other infections - LSHTM Research Online | London School of Hygiene and Tropical MedicineMalaria and susceptibility to other infections - LSHTM Research Online | London School of Hygiene and Tropical Medicine
Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and to determine the importance of these mechanisms in a translational system moving from a mouse model to human malaria. The most frequently cited immunological consequences of malaria are: suppression of vaccine responses, susceptibility to bacterial infection, susceptibility to endemic Burkitt lymphoma, and increased HIV viral load. Of these, susceptibility to non-Typhoid Salmonella (NTS) bacteremia, associated with severe hemolysis, was the most consistent between animal and human studies. I hypothesized that hemolysis would induce the immunomodulatory enzyme heme oxygenase-l (HO-l), which is essential for survival in malaria infections in mice, but might impair host defence against NTS. I demonstrate in mice that malaria, chemically-induced ...
http://researchonline.lshtm.ac.uk/901045/
Childhood Non-Hodgkin Lymphoma Treatment (PDQ )
A bispecific monoclonal antibody is made up of two different monoclonal antibodies that bind to two different substances and kills cancer cells. Bispecific monoclonal antibody therapy is used in the treatment of Burkitt and Burkitt-like lymphoma/leukemia and diffuse large B-cell lymphoma.. Tyrosine kinase inhibitors (TKIs) block signals that tumors need to grow. Some TKIs also keep tumors from growing by preventing the growth of new blood vessels to the tumors. Other types of kinase inhibitors, such as crizotinib, are being studied for childhood non-Hodgkin lymphoma.. Immunotoxins can bind to cancer cells and kill them. Denileukin diftitox is an immunotoxin used to treat cutaneous T-cell lymphoma.. Targeted therapy is being studied for the treatment of childhood non-Hodgkin lymphoma that has recurred (come back).. See Drugs Approved for Non-Hodgkin Lymphoma for more information.. Other drug therapy. Retinoids are drugs related to vitamin A. Retinoid therapy with bexarotene is used to treat ...
https://www.meb.uni-bonn.de/cancer.gov/CDR0000258002.html
OPUS 4 | SearchOPUS 4 | Search
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
http://publikationen.ub.uni-frankfurt.de/solrsearch/index/search/searchtype/authorsearch/author/%22Markus+L%C3%B6ffler%22
OPUS 4 | SearchOPUS 4 | Search
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
http://publikationen.ub.uni-frankfurt.de/solrsearch/index/search/searchtype/authorsearch/author/%22Wolfram+Klapper%22
Henry Löffler-WirthHenry Löffler-Wirth
BACKGROUND: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic … phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. METHODS: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and ...
https://www.health-atlas.de/people/17
Burkitts lymphoma of the colon
Burkitt-like post-transplant lymphoproliferative disorder (PTLD) presenting with breast mass in a renal transplant recipient: a report of a rare case. Law, Man; Chan, Hay; Leung, Charlotte; Lai, Ho; Ha, Chung; Ng, Celia; Yeung, Yiu; Yip, Sze // Annals of Hematology;Dec2014, Vol. 93 Issue 12, p2083 A letter to the editor is presented in response to the article which discusses the Burkitt-like post-transplant lymphoproliferative disorder (PTLD) with breast mass in a renal transplant recipient that was published in the one of the previous issue of the periodical. ...
http://connection.ebscohost.com/c/abstracts/66954903/burkitts-lymphoma-colon
glossary:burkitt s tumor [Lymphedema People]glossary:burkitt s tumor [Lymphedema People]
Burkitts lymphoma, Burkitts tumor A form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma. The Epstein-Barr virus (EB virus), a gammaherpes virus, has been isolated from Burkitts lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans. Also known as Burkitts Lymphoma ...
http://lymphedemapeople.com/wiki/doku.php?id=glossary:burkitt_s_tumor
Epidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM) - Full Text View - ClinicalTrials.govEpidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM) - Full Text View - ClinicalTrials.gov
Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. Epstein-Barr virus (EBV) and malaria are epidemiologically linked to endemic BL in epidemiologic studies, but questions remain about role of EBV variants and the evidence for association with malaria is weak. EBV is ubiquitous, yet only few children develop BL, possibly because only a few EBV variants are pathogenitically relevant. The association of BL with malaria is based on ecologic and non-comparative clinical studies. Two case-control studies have reported significant association of high anti-malarial antibodies with BL (OR=5_ among children in Uganda and in Malawi, but selection bias (cases and controls came from dissimilar geographical areas) and reverse causality bias were limitations. Three studies were conducted in the 1960s and 70s to test association of carriage of malaria-resistance gene with ...
https://clinicaltrials.gov/ct2/show/NCT01196520
Epidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM) - Tabular View - ClinicalTrials.govEpidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM) - Tabular View - ClinicalTrials.gov
Burkitt lymphoma (BL) is an aggressive monoclonal B-cell malignancy that is rare (sporadic) worldwide, but is 100-fold more common (endemic) in equatorial Africa, particularly among children. Epstein-Barr virus (EBV) and malaria are epidemiologically linked to endemic BL in epidemiologic studies, but questions remain about role of EBV variants and the evidence for association with malaria is weak. EBV is ubiquitous, yet only few children develop BL, possibly because only a few EBV variants are pathogenitically relevant. The association of BL with malaria is based on ecologic and non-comparative clinical studies. Two case-control studies have reported significant association of high anti-malarial antibodies with BL (OR=5_ among children in Uganda and in Malawi, but selection bias (cases and controls came from dissimilar geographical areas) and reverse causality bias were limitations. Three studies were conducted in the 1960s and 70s to test association of carriage of malaria-resistance gene with ...
https://clinicaltrials.gov/ct2/show/record/NCT01196520
Denis Parsons Burkitt - WikipediaDenis Parsons Burkitt - Wikipedia
Denis Parsons Burkitt FRS (28 February 1911 - 23 March 1993), surgeon, was born in Enniskillen, County Fermanagh, Ireland. He was the son of James Parsons Burkitt, a civil engineer. Aged eleven he lost his right eye in an accident. He attended Portora Royal School in Enniskillen and Dean Close School, England. In 1929 Burkitt entered Trinity College, Dublin, to study engineering, but believing his evangelical calling was to be a doctor, he transferred to medicine. In 1938 he passed the Edinburgh Royal College of Surgeons fellowship examinations. On 28 July 1943 he married Olive Rogers. During World War II, Burkitt served with the Royal Army Medical Corps in England and later in Kenya and Somaliland. After the war, Burkitt decided his future lay in medical service in the developing world and he moved to Uganda. He eventually settled in Kampala and remained there until 1964. Burkitt made two major contributions to medical science related to his experience in Africa. The first was the description, ...
https://en.wikipedia.org/wiki/Denis_Parsons_Burkitt
Burkitts lymphoma | definition of Burkitts lymphoma by Medical dictionaryBurkitts lymphoma | definition of Burkitts lymphoma by Medical dictionary
Looking for online definition of Burkitts lymphoma in the Medical Dictionary? Burkitts lymphoma explanation free. What is Burkitts lymphoma? Meaning of Burkitts lymphoma medical term. What does Burkitts lymphoma mean?
http://medical-dictionary.thefreedictionary.com/Burkitt
Sambo Medical
Updated cell lines for exosome production includes also HEK293 cell line (Human Embryonic Kidney cells 293). Lyophilized and purified exosomes from cell culture medium. • PC3 cell line (human prostate adenocarcinoma grade IV) • BPH-1 cell line (human being prostatic hyperplasia) • DAUDI cell line (human burkitt lymphoma) • A549 cell line (lung carcinoma) • K-562 cell line (pleural effusion, leukemia chronic myelogenous) • B16F10 mouse cell line (mouse melanoma cell line) • HEK293 cell line (human embryonic kidney) Lyophilized Exosome Standards. Lyophilization is the ideal technique for preserving the long-term stability of exosomes at 4 .. Lyophilized exosomes can be used as control standards for multiple applications including FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.. Lyophilized exosomes are easy to ship and store, and are stable for 12 months at 4 . Purified and lyophilized exosomes are obtained from a ...
http://www.sambomed.co.kr/renewal/bbs/board.php?bo_table=products&wr_id=2182
Partial Purification and Electron Microscopy of Virus in the EB-3 Cell Line Derived from a Burkitt Lymphoma | SciencePartial Purification and Electron Microscopy of Virus in the EB-3 Cell Line Derived from a Burkitt Lymphoma | Science
The virus in the EB-3 cell line derived from a Burkitt lymphoma was partially purified by digestion with proteolytic enzyme and by density-gradient centrifugation on potassium tartrate. Electron microscope studies of both sectioned and negatively stained samples suggest that the virus belongs to the herpes-virus group, although the exact number of capsomeres was not unequivocally established. ...
http://science.sciencemag.org/content/152/3725/1084
Burkitt Lymphoma Treatment Market Analysis 2021: Industry Growth Factors, Types, Applications, Top Players, Regional Insights...Burkitt Lymphoma Treatment Market Analysis 2021: Industry Growth Factors, Types, Applications, Top Players, Regional Insights...
Burkitt Lymphoma Treatment Market Analysis 2021: Industry Growth Factors, Types, Applications, Top Players, Regional Insights To 2027
https://www.stratagemmarketinsights.com/report/burkitt-lymphoma-treatment-market-35859
Burkitt lymphoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramBurkitt lymphoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Burkitt lymphoma
https://rarediseases.info.nih.gov/diseases/5973/burkitt-lymphoma
Plus itPlus it
Incorporation of thalidomide, lenalidomide, and pomalidomide into the myeloma therapeutic armamentarium has contributed substantially to patient survival. Given the contributory role, EBV plays in approximately 50% of Hodgkin lymphoma, and reports of Hodgkin lymphoma in patients on lenalidomide-MT, we hypothesized that lenalidomide, and its analogues thalidomide and pomalidomide, may induce EBV reactivation. This hypothesis was further supported by the fact that the immunosuppressant methotrexate in nonmalignant diseases such as rheumatoid arthritis enhanced the risk of EBV-positive lymphomas (9). In this study, we found that LTP reactivated EBV in latently infected B-cell lines in the order of efficacy pomalidomide , lenalidomide , thalidomide. LCL cells were weakly inducible into lytic cycle, whereas Burkitt lymphoma cells were readily induced (Fig. 1). Combinations of ganciclovir with lenalidomide or pomalidomide enhanced the growth inhibitory effect in Burkitt lymphoma cells (Fig. 2C and ...
http://clincancerres.aacrjournals.org/content/22/19/4901
Epstein-Barr virus load is higher in rheumatoid arthritis patients than in normal controls | Arthritis Research & Therapy |...Epstein-Barr virus load is higher in rheumatoid arthritis patients than in normal controls | Arthritis Research & Therapy |...
Eighty-four patients fulfilling the 1987 ACR criteria for RA and 22 patients with rheumatic conditions other than RA were studied. Sixty-nine healthy controls were chosen from bone marrow donors at the Marseille blood transfusion center. HLA-DR genotyping of patients and controls was performed by PCR-SSP. Real-time PCR was performed using a Roche LightCycler. A 214-bp fragment from the highly conserved long internal repeat IR1 was amplified. Two specific hybridization probes were used to recognize adjacent internal sequences within the target. EBV-positive Burkitts lymphoma cell line was used as an external standard. ...
https://arthritis-research.biomedcentral.com/articles/10.1186/ar713
Mendeley Data - KCH Lymphoma Study Burkitt DatabaseMendeley Data - KCH Lymphoma Study Burkitt Database
Database of prospective cohort of Burkitt lymphoma patients at Kamuzu Central Hospital, Lilongwe, Malawi. Manuscript published in Blood Advances; Painschab, et al., 2019. ABSTRACT Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL is highly curable with chemotherapy. However, there are few prospective studies from SSA describing non-pediatric BL and no regional standard of care. Thirty-five participants aged ≥15 years with newly diagnosed BL from 2013-2018 in Malawi were enrolled. Chemotherapy was administered according to local institutional guidelines, with concurrent antiretroviral therapy (ART) if HIV-infected. Median age was 21 (range 15-61) and 15 (43%) participants were HIV-infected. Twenty-seven (77%) participants had stage III/IV disease and 19 (54%) had ECOG performance status (PS) |1. Among HIV-infected, median CD4 count was 130 (range 29-605), and ten (67%) had suppressed HIV viral load. Four (11%) patients died before chemotherapy initiation. First
https://data.mendeley.com/datasets/d857z43fjr
Letter: childhood lymphoma resembling Burkitts tumour in the southern Argentine. | Archives of Disease in ChildhoodLetter: childhood lymphoma resembling Burkitts tumour in the southern Argentine. | Archives of Disease in Childhood
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
http://adc.bmj.com/content/49/12/970.2
symposia.mtholyoke.edu
Induction of Epstein-Barr Virus Lytic Replication Beth Israel Deaconess Medical Center, Boston, Dr. Joyce Fingeroth Student Presenter: Anastasia Hyrina Project Advisor: Craig Woodard Epstein-Barr virus (EBV) is a member of the herpesvirus family and is one of the most common human viruses. In the United States, 95% of adults between 35 and 40 years of age have been infected with EBV1. EBV is the etiological agent of infectious mononucleosis and is associated with a number of diverse lymphomas and epithelial cancers, including African Burkitts lymphoma, nasopharyngeal carcinoma and gastric malignancies2. Though EBV primarily infects B lymphocytes and epithelial cells, the sequence of infection is not well understood. In infected B cells, EBV establishes persistent latent infections. The latent state of the virus in a cell is characterized by expression of a small subset of viral genes and the latent membrane proteins, which are essential for induction and maintenance of cellular proliferation ...
http://pdfdrug.com/s/symposia.mtholyoke.edu1.html
Burkitts lymphoma: new insights into molecular pathogenesis | Journal of Clinical PathologyBurkitts lymphoma: new insights into molecular pathogenesis | Journal of Clinical Pathology
BL occurs as an Epstein-Barr virus (EBV) associated malignancy among children in the malaria belt of equatorial Africa (endemic BL),5 and sporadically in other geographical areas, where it also occurs among adults (sporadic BL).6,7 The most common site of involvement of endemic BL is the kidneys. Jaw tumours are age related with an overall incidence in Uganda of 50%.7 In contrast, the terminal ileum and lymph nodes are the more commonly involved sites in sporadic BL.8,9 A common translocation t(8;14) and the consequent c-myc rearrangement and overexpression have been identified in endemic and sporadic BL. However, some not very strict associations between JH and DH recombination have been identified at 14q32, with distant 5 c-myc recombination in endemic cases of BL, whereas in sporadic cases Sμ and Sα recombination was identified10 at 14q32, with near 5 or intronic c-myc recombination at 8q24. These differences between endemic and sporadic BL do not mean that each of these subtypes of ...
http://jcp.bmj.com/content/56/3/188
Burkitt Surname, Family Crest & Coats of ArmsBurkitt Surname, Family Crest & Coats of Arms
Read the Burkitt surname history and see the family crest, coat of arms for the English Origin. Discover the Burkitt surname history. Where did the name Burkitt come from?
https://www.houseofnames.com/burkitt-family-crest
The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker to identify c-MYC translocated lymphomas |...The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker to identify c-MYC translocated lymphomas |...
Background During B-cell development, precursor B-cells transiently express the pre-B-cell receptor composed of μ heavy chain complexed with VpreB and λ5 surrogate light chain polypeptides. Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B-cells and Burkitt lymphoma. Design and Methods Here, we used a novel antibody to investigate the normal expression pattern of VpreB3 protein in human hematolymphoid tissues, and determine whether VpreB3 can serve as a useful diagnostic biomarker for select B-cell lymphomas. Results We found that VpreB3 protein is normally expressed by precursor B-cells in bone marrow and by a subset of normal germinal center B-cells in secondary lymphoid organs. Among lymphoid malignancies, we found an association between VpreB3 expression and B-cell tumors with c-MYC abnormalities. VpreB3 was highly expressed in all cases of Burkitt lymphoma, whether of endemic or sporadic origin (44/44 ...
http://www.haematologica.org/content/early/2010/09/07/haematol.2010.025767
Severe Hepatic Sinusoidal Obstruction Syndrome during the Induction Chemotherapy of Burkitts LymphomaSevere Hepatic Sinusoidal Obstruction Syndrome during the Induction Chemotherapy of Burkitts Lymphoma
The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitts lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.
https://scirp.org/journal/papercitationdetails.aspx?paperid=82925&JournalID=806
Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer TherapeuticsSmall Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
1. Dang C V. MYC on the Path to Cancer. Cell. 2012;149(1):22-35 2. Fernandez PC, Frank S R, Wang L. et al. Genomic targets of the human c-Myc protein. Genes & development. 2003;17(9):1115-1129 3. Li Z, Van Calcar S, Qu C. et al. A global transcriptional regulatory role for c-Myc in Burkitts lymphoma cell. PNAS. 2003;100(14):8164-8169 4. Lin CY, Lovén J, Rahl PB. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151(1):56-67 5. Zhang X, Zhao X, Fiskus W. et al. Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas. Cancer cell. 2012;22(4):506-523 6. Berg T. Small-molecule modulators of c-Myc/Max and Max/Max interaction. Curr Top Microbio Immunol. 2011;348:139-149 7. Lin CP, Liu CR, Lee CN. et al. Targeting c-Myc as a novel approach for hepatocellular carcinoma. World J Hepatol. 2010;2(1):16-20 8. Zhang W, Kater AP, Widhopf GF. et al. B-cell activating factor and v-Myc ...
http://www.ijbs.com/v10p1084.htm
2021 ICD-10-CM Diagnosis Code C83.78: Burkitt lymphoma, lymph nodes of multiple sites2021 ICD-10-CM Diagnosis Code C83.78: Burkitt lymphoma, lymph nodes of multiple sites
Free, official coding info for 2021 ICD-10-CM C83.78 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C83-/C83.78
2018 ICD-10-CM Diagnosis Code C83.76: Burkitt lymphoma, intrapelvic lymph nodes2018 ICD-10-CM Diagnosis Code C83.76: Burkitt lymphoma, intrapelvic lymph nodes
Free, official coding info for 2018 ICD-10-CM C83.76 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
http://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C83-/C83.76
Su-jok acupuncture methods and treatment (Su-jok medicine blog): Burkitt lymphoma, very serious case, distant healing, updateSu-jok acupuncture methods and treatment (Su-jok medicine blog): Burkitt lymphoma, very serious case, distant healing, update
The boy is reported having high-dose chemo, with all possible accompanying effects, anyway, hes fighting, and it seems the situation is not getting worse. ...
http://acupunctureforcancerideas.blogspot.com/2017/07/burkitt-lymphoma-very-serious-case.html
Burkitt , Denis ParsonsBurkitt , Denis Parsons
(1911-1993) British surgeon Born in Enniskillen, now in Northern Ireland, Burkitt attended Dublin University, receiving his BA in 1933 and MB in 1935. Having become a fellow of Edinburgh s Royal College of Surgeons in 1938, Burkitt served in the…
http://scientists.enacademic.com/232/
People touched by Burkitts Archives - Burkitts Lymphoma SocietyPeople touched by Burkitts Archives - Burkitts Lymphoma Society
al.. Superman and Captain America. Two strong characters, no doubt about that. These are the nicknames I gave two little premature infant boys I had helped take care of in the neonatal ICU spring 2007. Watching these tiny guys fight for their lives, grow, and go through various trials was routine to me. It was not routine for their mom and dad. I gave them these nicknames for fun. One day the mother asks me why I call Hagan Superman. I said, because he had strength he didnt even know he had.. I became ill January 14th, 2008 on a Monday evening at church. I felt the distinct feeling of the flu: fever, chills, and cold to the bone. The next morning, I felt better and went to work. Driving on I-30, pain began in my lower back. The pain was on the move and increased quickly. I thought I was having a heart attack. I went to the nearest ER and was admitted. 7 days in a hospital revealed I was healthy except for an elevated white blood cell count. No diagnosis was given other than ...
http://burkittslymphomasociety.com/archives/category/storieis-from-people-touched-by-burkitts
In areas of the world in which malaria is endemic, notably in sub-Saharan Africa, EBV can cause Burkitts lymphoma in children,...
A) EBV infection makes the malarial parasite able to produce lymphoma. B) Malarias strain on the immune system makes EBV infection worse. C) Malaria occurs
https://onepapermcqs.com/in-areas-of-the-world-in-which-malaria-is-endemic-notably-in-sub-saharan-africa-ebv-can-cause-burkitts-lymphoma-in-children-which-is-usually-associated-with-large-tumors-of-the-jaw-which-of-the-f/
Vimentin IHC Antibody, Ready to Use
The VIM gene was one of many that Gieser and Swaroop (1992) recovered from a subtracted cDNA library for retinal pigment epithelium. Vimentin gene express in human lymphocytes and in Burkitts lymphoma cells. Vimentin is secreted by activated macrophages. The gene encoding human vimentin is located on the short arm of chromosome 10.. ...
http://www.ihcworld.com/products/antibody-datasheets/Vimentin.IW-MA1102.htm
Contemporary Clinical Dentistry - Maxillary sporadic <i>Burkitts lymphoma</i> associated with neuro-orbital involvement in an...Contemporary Clinical Dentistry - Maxillary sporadic <i>Burkitts lymphoma</i> associated with neuro-orbital involvement in an...
This is a temporary file and hence do not link it from a website, instead link the URL of this page if you wish to link the PDF file ...
https://www.contempclindent.org/downloadpdf.asp?issn=0976-237X
Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of...Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of...
For a balanced presentation, it is important to discuss the evidence in favor of the somatic-mutation theory. We present seven arguments used to support the somatic mutation theory and offer some alternative explanations related to the theory that the initiating event is a disruption of the morphostat gradient which then may be followed by genetic instability. The first four arguments rely on a recent review article on oncogenes and cancer [38] from which we quote extensively.. (1) The first evidence that cancer arises from somatic genetic alterations came from studies of Burkitts lymphoma, in which one of three different translocations juxtaposes an oncogene, MYC.... Since every malignant lymphocyte carries the MYC translocation, deregulation of the MYC oncogene is probably the initiating event [38]. An alternative interpretation is that the MYC translocation indicates a late-stage event in carcinogenesis after the disruption of the morphostat gradient.. (2) Second, transfection experiments ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-89
HIV and Stem Cell TransplantationHIV and Stem Cell Transplantation
The incidence of AIDS-defining malignancies (ADMs) and NADMs has undergone a variety of changes in the ART era. Rates of ADMs, including NHL, have largely fallen [2-6], although within NHL there is an increasing proportion of Burkitt lymphomas [6, 7]. Additionally, the reported rates of HL, an NADM, have remained constant [4, 8-11] or increased [2, 3, 12-14]. Regardless, the risk for NHL and HL remains greater than for the general population [3, 15, 16]. For instance, the standardized incidence ratio of NHL in HIV-infected individuals from 1996 to 2002 was 22.6 [95% CI 20.8-24.6], as compared with that of the general population enrolled in the Surveillance, Epidemiology, and End Results Program registry [3]. In the Center for AIDS Research Network of Integrated Clinical Systems cohort, among incident cancer cases diagnosed in ART-treated patients from 1996 to 2009, NHL comprised 18%, primary central nervous systemNHL 3%, and HL 5% [17]. While hematologic malignancies did not represent ...
http://www.natap.org/2014/HIV/081814_03.htm
TrainingTraining
Dr. Mutyaba has had multiple training opportunities with Fred Hutch Global Oncology. First, he was an HIV-Associated Malignancy fellow between 2009-2010, where he took graduate classes at the University of Washington Schools of Medicine and Public Health and participated in clinical rotations at the Seattle Cancer Care Alliance. Dr. Mutyaba conducted research to understand the relationship between the use of antiretroviral therapy and cancer incidence in Uganda. After returning to Uganda, he became Global Oncologys Burkitt Lymphoma Project Study Coordinator and matriculated the Master of Medicine program at Makerere University (expected award date of January 2016). In March 2011, he became Global Oncologys first Ugandan fellow to receive independent funding through a two-year startup catalytic grant, Beginning Investigator Grant for Catalytic Research (BIG Cat), from the African Organization for Research and Training in Cancer (AORTIC) and National Cancer Institute. He presented his research ...
https://www.fredhutch.org/en/labs/vaccine-and-infectious-disease/international-programs/global-oncology/uganda/training.html
Inhibitor of Differentiation Proteins | Harvard Catalyst Profiles | Harvard CatalystInhibitor of Differentiation Proteins | Harvard Catalyst Profiles | Harvard Catalyst
Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet. 2012 Dec; 44(12):1316-20 ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Inhibitor%20of%20Differentiation%20Proteins
PMAD Edition T ShirtPMAD Edition T Shirt
Pennies Make A Dime Inc. (PMAD) is committed to helping orphans and vulnerable children in Africa, especially those infected and affected with Burkitt Lymphomas,by enhancing access to health care, education, nutritional support and career development
https://www.penniesmakeadime.org/store/p8/PMAD_Edition_T_Shirt.html
SBL Bovista Dilution 3 CH: Buy bottle of 30 ml Dilution at best price in India | 1mgSBL Bovista Dilution 3 CH: Buy bottle of 30 ml Dilution at best price in India | 1mg
Order SBL Bovista Dilution 3 CH:bottle of 30 ml Dilution online at best price in India. Know SBL Bovista Dilution 3 CH price, specifications, benefits and other information only on 1mg.com
https://www.1mg.com/otc/sbl-bovista-dilution-3-ch-otc351395?qv=NaN&iv=undefined
Burkitt lymphomaBurkitt lymphoma
... of lymphoma cases can be attributed to Burkitt lymphoma. The peak incidence for endemic Burkitt lymphoma is from ages 4 to 7 ... Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis. Burkitt lymphoma can be divided into three main ... EBV infection is associated with Burkitt lymphoma. EBV is found in virtually all instances of endemic Burkitt lymphoma. The ... "Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology". 29 June 2017. ...
https://en.wikipedia.org/wiki/Burkitt_lymphoma
Denis Parsons BurkittDenis Parsons Burkitt
Books Burkitt, D. P.; Wright, D. H. (1970). Burkitt's Lymphoma. Livingstone. ISBN 0443007004. LCCN 72021505. Burkitt, D. P.; ... Denis P. Burkitt, "Discovering Burkitt's Lymphoma" in Paul H. Levine, Epstein-Barr Virus and Human Disease (Humana Press 1987) ... Burkitt, together with Dr. Dennis Wright, published a book titled Burkitt's Lymphoma in April 1970. His second major ... Biography Dennis Wright Archived 26 June 2009 at the Wayback Machine Burkitt, D. P; Wright, Dennis H (1970). Burkitt's lymphoma ...
https://en.wikipedia.org/wiki/Denis_Parsons_Burkitt
Aggressive lymphomaAggressive lymphoma
These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, ... Burkitt lymphoma is named after the British surgeon Denis Burkitt. Burkitt identified this disease in 1956 in children in ... AIDS-associated lymphoma Angioimmunoblastic lymphoma Central nervous system (CNS) lymphoma Mantle cell lymphoma (MCL) Some of ... diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. Diffuse large B-cell lymphoma ...
https://en.wikipedia.org/wiki/Aggressive_lymphoma
Dennis H. WrightDennis H. Wright
Denis Burkitt in describing the pathology of Burkitt lymphoma. Wright became a leading expert on lymphomas. In 1964 he ... Burkitt, Denis P.; Wright, Dennis H. (1970). Burkitt's Lymphoma. Edinburgh: Livingstone. ISBN 0443007004. LCCN 72021505; xi+251 ... He received in 1973 the Paul Ehrlich and Ludwig Darmstaedter Prize for his research on the pathology of Burkitt lymphoma. He ... he and his coworkers were among the first to describe T-cell lymphomas associated with enteropathy and to describe lymphomas of ...
https://en.wikipedia.org/wiki/Dennis_H._Wright
Epstein-Barr virus infectionEpstein-Barr virus infection
... causing excessive proliferation observed as Burkitt's lymphoma. Burkitt's lymphoma commonly affects the jaw bone, forming a ... Burkitt's lymphoma is a type of Non-Hodgkin's lymphoma and is most common in equatorial Africa and is co-existent with the ... Nasopharyngeal cancer Several Non-Hodgkin's lymphomas, including Burkitt's lymphoma and primary cerebral lymphoma Post- ... Burkitt's lymphoma, and Epstein-Barr virus positive diffuse large B-cell lymphoma, not otherwise specified); 2) non-lymphoid ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus_infection
List of OMIM disorder codesList of OMIM disorder codes
MAOA Burkitt's lymphoma; 113970; MYC Buschke-Ollendorff syndrome; 166700; LEMD3 C syndrome; 211750; CD96 C5 deficiency; 609536 ... FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin, somatic; 605027; RAD54L Lymphoproliferative syndrome, EBV- ... GNE Non-Hodgkin lymphoma, somatic; 605027; CASP10 Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in; 211980; ... HMGCS2 Hodgkin's lymphoma; 236000; KLHDC8B Holocarboxylase synthetase deficiency; 253270; HLCS Holoprosencephaly-2; 157170; ...
https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
Bozoma Saint JohnBozoma Saint John
"Peter Saint John". Burkitt's Lymphoma Society. 2013. Archived from the original on June 9, 2017. Retrieved June 9, 2017. "In ...
https://en.wikipedia.org/wiki/Bozoma_Saint_John
Alexander John HaddowAlexander John Haddow
Burkitt, D. P. (1971). "Epidemiology of Burkitt's Lymphoma". Proceedings of the Royal Society of Medicine. 64 (9): 909-910. doi ... Other notable work included relating the incidence of Burkitt's lymphoma to climatic conditions and the discovery of several ... Haddow's most prominent work was considered to be that on yellow fever and Burkitt's lymphoma. The Zika virus has since emerged ...
https://en.wikipedia.org/wiki/Alexander_John_Haddow
Azzopardi phenomenonAzzopardi phenomenon
Peng SL, Cheng CN, Chang KC (2007). "Burkitt lymphoma with Azzopardi phenomenon". Arch. Pathol. Lab. Med. 131 (5): 682-3. doi: ...
https://en.wikipedia.org/wiki/Azzopardi_phenomenon
Epstein-Barr virus-associated lymphoproliferative diseasesEpstein-Barr virus-associated lymphoproliferative diseases
Burkitt lymphoma (BL); Hodgkin lymphoma (HL); plasmablastic lymphoma (PBL); and primary effusion lymphoma (PEL) (also termed ... Burkitt lymphoma occurs in three forms. Epidemic Burkitt lymphoma (eBL) is common in Africa, the Middle East, Brazil, Papua New ... Two extremely rare types of the intravascular lymphomas, intravascular NK-cell lymphoma and intravascular T- cell lymphoma, are ... angioimmunoblastic T-cell lymphoma (AITL), and anaplastic lymphoma kinase positive or negative anaplastic large-cell lymphoma ( ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus–associated_lymphoproliferative_diseases
LL-100 panelLL-100 panel
PULVERTAFT, JV (1 February 1964). "Cytology of Burkitt's Tumour (African Lymphoma)". Lancet. 1 (7327): 238-40. doi:10.1016/ ... established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma". Leukemia & Lymphoma. 43 (11): 2179- ... "Characteristics of new cell lines derived from Burkitt lymphomas". Cancer. 23 (1): 64-79. doi:10.1002/1097-0142(196901)23:1. ... "An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and ...
https://en.wikipedia.org/wiki/LL-100_panel
1958 in science1958 in science
Denis Parsons Burkitt first describes Burkitt's lymphoma. February 7 - Discovery of "Deep Skull" in Niah Caves in Sarawak by ... synd/2511 at Who Named It? Burkitt, D. (1958). "A sarcoma involving the jaws in African children". The British Journal of ...
https://en.wikipedia.org/wiki/1958_in_science
Epstein-Barr virus stable intronic-sequence RNAsEpstein-Barr virus stable intronic-sequence RNAs
Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma). Non-coding RNAs (ncRNAs) have a role in this process. ... of endemic Burkitt's lymphoma. Splicing of these W repeat transcripts produces a short intron and a long intron (Fig. 1), both ... "An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus_stable_intronic-sequence_RNAs
Deaths in June 2009Deaths in June 2009
Anthony Yeo, 60, Singaporean counsellor, Burkitt's lymphoma. Gilda Galán, 92, Puerto Rican actress. Lorena Gale, 51, Canadian ... Alan Berkman, 63, American physician and activist, lymphoma. Fleur Cowles, 101, American writer, editor and artist. Baciro Dabó ... Luo Jing, 48, Chinese news presenter, lymphoma. Adilgerei Magomedtagirov, 53, Russian general, Interior Minister for the ... Fred Travalena, 66, American comedian and impressionist, non-Hodgkin lymphoma. Lucia Lauria Vigna, 113, Italian ...
https://en.wikipedia.org/wiki/Deaths_in_June_2009
List of breast cancer patients by survival statusList of breast cancer patients by survival status
Treated for breast cancer and Burkitt's lymphoma; pending remission from both cancers. Dorothy Hamill (born 1956), American ...
https://en.wikipedia.org/wiki/List_of_breast_cancer_patients_by_survival_status
LymphomaLymphoma
Burkitt lymphoma; large B cell lymphoma, not otherwise specified; diffuse large B cell lymphoma associated with chronic ... Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma ... Hodgkin lymphoma Classical Hodgkin lymphomas: Nodular sclerosis form of Hodgkin lymphoma Most common type of Hodgkin lymphoma ... large B-cell lymphoma ALK+ large B-cell lymphoma Plasmablastic lymphoma Primary effusion lymphoma Large B-cell lymphoma arising ...
https://en.wikipedia.org/wiki/Lymphoma
Bert AchongBert Achong
Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt lymphoma samples by ... Epstein, M.A; Achong, B.G; Barr, Y.M (1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". The Lancet. ... Epstein, Anthony (2012-03-01). "Burkitt lymphoma and the discovery of Epstein-Barr virus". British Journal of Haematology. 156 ... "Morphological and Biological Studies on a Virus in Cultured Lymphoblasts from Burkitt's Lymphoma". Journal of Experimental ...
https://en.wikipedia.org/wiki/Bert_Achong
History of cancerHistory of cancer
Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ...
https://en.wikipedia.org/wiki/History_of_cancer
Namrata Singh GujralNamrata Singh Gujral
... she was treated for Burkitt's lymphoma. She was treated with aggressive chemotherapy including intrathecal chemotherapy at City ... The cause of lymphoma was prior chemotherapy from 2008 for breast cancer. In 2013, Gujral was in remission from both cancers. ... Lisa Tsering (2013-08-06). "Actress fights lymphoma Urges Community Awareness". India West. Archived from the original on 2013- ...
https://en.wikipedia.org/wiki/Namrata_Singh_Gujral
1964 in science1964 in science
Epstein, M. A.; Achong, B. G.; Barr, Y. M. (1964-03-28). "Virus particles in cultured lymphoblasts from Burkitt's lymphoma". ...
https://en.wikipedia.org/wiki/1964_in_science
QSER1QSER1
Overexpression of QSER1 was noted in Burkitt's Lymphoma. QSER1 expression also increases with increasing Gleason score (more ... Altered expression of QSER1 is noted in pathological cardiomyopathy, Burkitt's Lymphoma, prostate cancer, and some breast ...
https://en.wikipedia.org/wiki/QSER1
Deaths in January 1998Deaths in January 1998
Nick Venet, 61, American record producer, Burkitt's lymphoma. Wayne Ambler, 82, American baseball player. Essie Coffey, 56, ... Sally Purcell, 53, British poet and translator, lymphoma of brain cells. Mae Questel, 89, American actress (Betty Boop), ... Junior Wells, 63, American blues vocalist and harmonica player, lymphoma. Gayane C'ebotaryan, 79, Armenian composer and ...
https://en.wikipedia.org/wiki/Deaths_in_January_1998
OncovirusOncovirus
In 1964 Anthony Epstein, Bert Achong and Yvonne Barr identified the first human oncovirus from Burkitt's lymphoma cells. A ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... Infectious causes of cancer Carcinogen Oncogenic Oncogene Adult T-cell leukemia/lymphoma Cancer bacteria Oncolytic virus, a ... B-cell non-Hodgkin's lymphoma, and cancer". World Journal of Hepatology. 7 (3): 327-343. doi:10.4254/wjh.v7.i3.327. PMC 4381161 ...
https://en.wikipedia.org/wiki/Oncovirus
Primary central nervous system lymphomaPrimary central nervous system lymphoma
Other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS lymphoma is highly associated with Epstein-Barr ... Primary central nervous system lymphoma (PCNSL), also termed primary diffuse large B-cell lymphoma of the central nervous ... Primary CNS Lymphoma~treatment at eMedicine Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, et al. ( ... Primary CNS Lymphoma at eMedicine Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA (March 2013). "A systematic ...
https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma
Epstein-Barr virusEpstein-Barr virus
... including Burkitt's lymphoma, hemophagocytic lymphohistiocytosis, Hodgkin's lymphoma, stomach cancer, nasopharyngeal carcinoma ... 2014). "The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey". Infectious Agents and ... Epstein MA, Achong BG, Barr YM (March 1964). "Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma". Lancet. 1 ( ... and hydroa vacciniforme as well as malignant lymphoproliferative diseases such as Epstein-Barr virus-positive Burkitt lymphoma ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus
Idiopathic CD4+ lymphocytopeniaIdiopathic CD4+ lymphocytopenia
... primary leptomeningeal lymphoma, diffuse large cell lymphoma,[non-primary source needed] MALT lymphoma, and Burkitt's lymphoma ... Shimano S, Murata N, Tsuchiya J (July 1997). "[Idiopathic CD4+ T-lymphocytopenia terminating in Burkitt's lymphoma]". Rinsho ... Campbell JK, Prince HM, Juneja SK, Seymour JF, Slavin M (April 2001). "Diffuse large cell lymphoma and t(8;22) (q24;q11) in a ... Lymphoma. 41 (3-4): 421-3. doi:10.3109/10428190109057998. PMID 11378556. S2CID 23366810. Longo F, Hébuterne X, Michiels JF, ...
https://en.wikipedia.org/wiki/Idiopathic_CD4 _lymphocytopenia
History of virologyHistory of virology
He was the first to describe a type of cancer that now bears his name Burkitt's lymphoma. This type of cancer was endemic in ... ISBN 978-1-904455-03-5. Bornkamm GW (April 2009). "Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more ... Magrath I (September 2009). "Lessons from clinical trials in African Burkitt lymphoma". Current Opinion in Oncology. 21 (5): ... In an attempt to find a cause for the cancer, Burkitt sent cells from the tumour to Anthony Epstein (b. 1921) a British ...
https://en.wikipedia.org/wiki/History_of_virology
Nick VenetNick Venet
He died on 2 January 1998 of Burkitt's lymphoma. Just over one month before Beach Boy Carl Wilson. He was survived by his wife ... Deaths from non-Hodgkin lymphoma, 20th-century American businesspeople, Deaths from cancer in California). ...
https://en.wikipedia.org/wiki/Nick_Venet
Sid CoucheySid Couchey
In February 2012, Couchey was diagnosed with Burkitt's lymphoma. The aggressive cancer took hold quickly, and Couchey died on ...
https://en.wikipedia.org/wiki/Sid_Couchey
MycMyc
The most frequently discussed example of c-Myc as a proto-oncogene is its implication in Burkitt's lymphoma. In Burkitt's ... A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive ... To study the mechanism of tumorigenesis in Burkitt lymphoma by mimicking expression pattern of Myc in these cancer cells, ... Iijima S, Teraoka H, Date T, Tsukada K (June 1992). "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. ...
https://en.wikipedia.org/wiki/Myc
Cervical cancerCervical cancer
Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, ... Noncarcinoma malignancies which can rarely occur in the cervix include melanoma and lymphoma. The International Federation of ...
https://en.wikipedia.org/wiki/Cervical_cancer
Galectin-9Galectin-9
"A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells". British ... Hodgkin and Non-Hodgkin lymphomas, AML or solid tumors, such as lung cancer, breast cancer, and hepatocellular carcinoma. ...
https://en.wikipedia.org/wiki/Galectin-9
Find-me signalsFind-me signals
CX3CL1 could also be released as part of microparticles from the beginning stages of apoptotic death of Burkitt Lymphoma cells ... is mediated through the release of a 60 kDa microparticle fragment of fractalkine from the beginning stages of Burkitt Lymphoma ...
https://en.wikipedia.org/wiki/Find-me_signals
Joseph H. BurchenalJoseph H. Burchenal
... a winner of the 1972 Albert Lasker Award for Medical Research for his work on developing a chemotherapy for Burkitt's lymphoma ...
https://en.wikipedia.org/wiki/Joseph_H._Burchenal
OncogeneOncogene
The MYC gene is implicated in Burkitt's lymphoma, which starts when a chromosomal translocation moves an enhancer sequence ...
https://en.wikipedia.org/wiki/Oncogene
NeprilysinNeprilysin
Follicular lymphoma (follicle centre cell lymphoma) are CD10+. Burkitt Lymphoma cells are CD10+. CD10+ diffuse large B cell ... and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells ... Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic ... "Differentiating between Burkitt lymphoma and CD10+ diffuse large B-cell lymphoma: the role of commonly used flow cytometry cell ...
https://en.wikipedia.org/wiki/Neprilysin
George ArcherGeorge Archer
Archer died of Burkitt's lymphoma - a lymphatic system malignancy - in Incline Village, Nevada in 2005, several days before his ... Deaths from lymphoma, Deaths from cancer in Nevada, 1939 births, 2005 deaths). ...
https://en.wikipedia.org/wiki/George_Archer
AIDS-defining clinical conditionAIDS-defining clinical condition
Kaposi's sarcoma Lymphoma, Burkitt's Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of brain Mycobacterium ... non-Hodgkin's lymphoma, lymphocytic leukemia, multiple myeloma, or any cancer of lymphoreticular or histiocytic tissue, or ...
https://en.wikipedia.org/wiki/AIDS-defining_clinical_condition
Robert James Valentine PulvertaftRobert James Valentine Pulvertaft
... carried out studies on Burkitt lymphoma. At the age of 70 Pulvertaft returned to England, settling in Dorset, and later moving ... After his retirement from Westminster, he travelled to Africa, where he conducted research on lymphoma. Pulvertaft returned to ...
https://en.wikipedia.org/wiki/Robert_James_Valentine_Pulvertaft
White blood cellWhite blood cell
Daniels VG, Wheater PR, Burkitt HG (1979). Functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone. ... cancers of white blood cells can be broadly classified as leukemias and lymphomas, although those categories overlap and are ...
https://en.wikipedia.org/wiki/White_blood_cell
Oncolytic virusOncolytic virus
Burkitt lymphoma, and Hodgkin lymphoma, after immunisation or infection with an unrelated virus appeared at the beginning of ...
https://en.wikipedia.org/wiki/Oncolytic_virus
Acute lymphoblastic leukemiaAcute lymphoblastic leukemia
Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... Burkitt leukemia) at presentation. The signs and symptoms of ALL are variable and include: Generalized weakness and feeling ... The WHO subtypes related to ALL are: B-lymphoblastic leukemia/lymphoma Not otherwise specified (NOS) with recurrent genetic ... August 2005). "Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas". ...
https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia
Tumors of the hematopoietic and lymphoid tissuesTumors of the hematopoietic and lymphoid tissues
... disorder Burkitt lymphoma Burkitt-like lymphoma with 11q aberration High-grade B-cell lymphoma High-grade B-cell lymphoma with ... large B-cell lymphoma Intravascular large B-cell lymphoma ALK-positive large B-cell lymphoma Plasmablastic lymphoma Primary ... MALT lymphoma) Nodal marginal zone lymphoma Paediatric nodal marginal zone lymphoma Follicular lymphoma In situ follicular ... lymphoma Large B-cell lymphoma with IRF4 rearrangement Primary cutaneous follicle centre lymphoma Mantle cell lymphoma In situ ...
https://en.wikipedia.org/wiki/Tumors_of_the_hematopoietic_and_lymphoid_tissues
Mir-26 microRNA precursor familyMir-26 microRNA precursor family
Burkitt lymphoma miR-26a plays a role as a potential tumor-suppressor in MYC-induced lymphoma. miR-26a is found to be ... downregulated in primary human Burkitt lymphoma and MYC-driven lymphoma cell lines. Ectopic expression of miR-26a influences ...
https://en.wikipedia.org/wiki/Mir-26_microRNA_precursor_family
Late life depressionLate life depression
April 2003). "Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells". ...
https://en.wikipedia.org/wiki/Late_life_depression
Triple-stranded DNATriple-stranded DNA
... with it playing a role in the development of Burkitt lymphoma and leukemia. The triple-stranded DNA regions can be generated ... translocation observed in many cancers and most follicular lymphomas. This observation has led to research that indicated a ...
https://en.wikipedia.org/wiki/Triple-stranded_DNA
Diffuse large B-cell lymphoma associated with chronic inflammationDiffuse large B-cell lymphoma associated with chronic inflammation
EBV+ Burkitt lymphoma, EBV+ Hodgkin lymphoma, and the EBV+ diffuse large B-cell lymphomas which include as a subtype, DLBCL-CI ... Articles with short description, Short description matches Wikidata, Lymphoma, Non-Hodgkin lymphoma, Lymphoid-related cutaneous ... Similar to DLBCL-CI, FA-DLBCL is a diffuse large B-cell lymphoma that arises in immunologically sequestered sites (e.g. body ... DLBCL-CI therefore appears to be a lymphoma that is driven by EBV-induced changes in the expression of various genes that ...
https://en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma_associated_with_chronic_inflammation
Ccdc109bCcdc109b
Changes in CCDC109B expression are also present in other diseases such as glioblastomas, Daudi Burkitt's lymphoma, Duchenne ... CCDC109B may contribute to a number of diseases including various lymphomas and leukemias. ...
https://en.wikipedia.org/wiki/Ccdc109b
Joe AndruzziJoe Andruzzi
On May 30, 2007, Andruzzi was diagnosed with non-Hodgkin's Burkitt's lymphoma, predicted to double in size in just 24 hours. ...
https://en.wikipedia.org/wiki/Joe_Andruzzi
Uganda Cancer InstituteUganda Cancer Institute
... to treat childhood lymphomas, predominantly Burkitt's lymphoma, the most common childhood lymphoma in Uganda and endemic to ... UCI was founded in 1967 with twenty beds, as the Lymphoma Treatment Center, ...
https://en.wikipedia.org/wiki/Uganda_Cancer_Institute
Julia BodmerJulia Bodmer
Burkitt's lymphoma and testicular cancer. As a consequence of her work at the ICRF she was able to contribute to the ...
https://en.wikipedia.org/wiki/Julia_Bodmer
List of MeSH codes (C04)List of MeSH codes (C04)
... lymphoma, non-hodgkin MeSH C04.557.386.480.150 - B-cell lymphoma MeSH C04.557.386.480.150.165 - burkitt lymphoma MeSH C04.557. ... burkitt lymphoma MeSH C04.557.386.480.450 - lymphoma, intermediate-grade MeSH C04.557.386.480.450.300 - lymphoma, large-cell, ... lymphoma, small noncleaved-cell MeSH C04.557.386.480.875.775.165 - burkitt lymphoma MeSH C04.557.386.720 - plasmacytoma MeSH ... lymphoma, small-cell MeSH C04.557.386.480.300 - lymphoma, diffuse MeSH C04.557.386.480.300.300 - lymphoma, large-cell, diffuse ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)
Merkel cell polyomavirusMerkel cell polyomavirus
Kaposi's sarcoma and Burkitt's lymphoma are examples of tumors known to have a viral etiology that occur at increased frequency ...
https://en.wikipedia.org/wiki/Merkel_cell_polyomavirus
ToothacheToothache
Various conditions may involve the alveolar bone, and cause non-odontogenic toothache, such as Burkitt's lymphoma,: 340 ...
https://en.wikipedia.org/wiki/Toothache
UWA-101UWA-101
2010). "Redesigning the designer drug ecstasy: nonpsychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity". ... but had potent anti-cancer effects against Burkitt's lymphoma cells in vitro. UWA-121 is the (R)-enantiomer of UWA-101 and the ... August 2012). "Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative ...
https://en.wikipedia.org/wiki/UWA-101
Burkitt lymphoma: MedlinePlus Medical EncyclopediaBurkitt lymphoma: MedlinePlus Medical Encyclopedia
... is a very fast growing form of non-Hodgkin lymphoma. ... Burkitt lymphoma (BL) is a very fast growing form of non- ... B-cell lymphoma; High-grade B-cell lymphoma; Small noncleaved cell lymphoma ... Adult non-Hodgkin lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment- ...
https://medlineplus.gov/ency/article/001308.htm
Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, VirginiaEpidemiologic Notes and Reports Burkitt's Lymphoma -- Winchester, Virginia
Epidemiologic Notes and Reports Burkitts Lymphoma -- Winchester, Virginia Three cases of Burkitts lymphoma (BL) have occurred ... editorial note: Burkitts lymphoma is extraordinarily rare outside certain parts of central Africa and New Guinea where it ... Brubaker G, Geser A, Pike MC: Burkitts lymphoma in the North Mara district of Tanzania 1964-70: Failure to find evidence of ... Levine PH, Sandler SG, Komp DM, et al: Simultaneous occurrence of American Burkitts Lymphoma in neighbors. N Engl J Med 288: ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00048532.htm
Browsing by Subject Burkitt LymphomaBrowsing by Subject "Burkitt Lymphoma"
Histopathological definition of Burkitts tumour  World Health Organization (‎World Health OrganizationWorld Health ...
https://apps.who.int/iris/browse?authority=Burkitt+Lymphoma&type=mesh
Burkitt Lymphoma and Burkitt-like Lymphoma Differential DiagnosesBurkitt Lymphoma and Burkitt-like Lymphoma Differential Diagnoses
... or small noncleaved cell lymphoma) is one of the highly aggressive B-cell non-Hodgkin lymphomas (NHL) that is characterized by ... the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved lymphoma, a historical term, ... encoded search term (Burkitt Lymphoma and Burkitt-like Lymphoma) and Burkitt Lymphoma and Burkitt-like Lymphoma What to Read ... Lymphoblastic lymphoma may be histologically similar to Burkitt lymphoma (BL), however, it is a T-cell lymphoma that expresses ...
https://emedicine.medscape.com/article/1447602-differential
Burkitt lymphoma, beyond discoveriesBurkitt lymphoma, beyond discoveries
... Guest edited by: Dr Sam Mbulaiteye. Burkitt Lymphoma (BL) is an aggressive non-Hodgkin ... Burkitt Lymphoma: beyond discoveries First described in 1958 in Uganda, Burkitt lymphoma (BL) attracted interest worldwide ... Particularly, Burkitts lymphoma belongs to the family of B Non Hodgkin aggressive lymphomas. Although it is morph... ... Identification of a novel variant of LMP-1 of EBV in patients with endemic Burkitt lymphoma in western Kenya Epstein Barr virus ...
https://www.biomedcentral.com/collections/burkitt-lymphoma
Browsing by Subject Burkitt LymphomaBrowsing by Subject "Burkitt Lymphoma"
Histopathological definition of Burkitts tumour  World Health Organization (‎World Health OrganizationWorld Health ...
https://extranet.who.int/iris/restricted/browse?locale-attribute=en&type=mesh&authority=Burkitt+Lymphoma
Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitts Non-Hodgkins Lymphoma...Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma...
Burkitts leukemia or Burkitts lymphoma or primary mediastinal large B-cell lymphoma. or B-precursor lymphoblastic lymphoma or ... Burkitts Lymphoma, Burkitts Leukemia, Mediastinal Neoplasms, Lymphoblastic Lymphoma, Large Cell Anaplastic Lymphoma ... Multicenter Study to Optimise Therapy of B-ALL, Burkitts NHL and High-Grade Non-Hodgkins Lymphoma in Adults (Amend 7). Trial ... Multicenter Study to Optimise Therapy of B-ALL, Burkitts NHL and High-Grade Non-Hodgkins Lymphoma in Adults (Amend 7) ...
http://www.knowcancer.com/cancer-trials/NCT00199082/
Burkitt Lymphoma Market - Request Customization FormBurkitt Lymphoma Market - Request Customization Form
Burkitt Lymphoma Market Size, Share, Trend, By Disease Type Outlook (Endemic, Sporadic, Immunodeficiency-Associated), By ... Burkitt Lymphoma Market. Burkitt Lymphoma Market Size, Share, Trend, By Disease Type Outlook (Endemic, Sporadic, ...
https://www.reportsanddata.com/request-customization-form/5367
Clinical significance of MYC expression and/or "High-grade" morphology in non-burkitt, diffuse aggressive B-cell lymphomas: A...
N2 - The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant ... AB - The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant ... The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show significant overlap ... abstract = "The clinicopathologic findings in Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) may show ...
https://mayoclinic.pure.elsevier.com/en/publications/clinical-significance-of-myc-expression-andor-high-grade-morpholo
ICD-10-CM Code C83.78 - Burkitt lymphoma, lymph nodes of multiple sitesICD-10-CM Code C83.78 - Burkitt lymphoma, lymph nodes of multiple sites
The ICD code C837 is used to code Burkitts lymphoma Burkitt lymphoma (Burkitts tumor, Burkitts lymphoma, or malignant ... Burkitt lymphoma, lymph nodes of multiple sites BILLABLE Billable Code Billable codes are sufficient justification for ... C83.78 is a billable ICD code used to specify a diagnosis of burkitt lymphoma, lymph nodes of multiple sites. A billable code ... DRG Group #840-842 - Lymphoma and non-acute leukemia with MCC. * DRG Group #840-842 - Lymphoma and non-acute leukemia with CC. ...
https://icd.codes/icd10cm/C8378
New prognostic index for Burkitt lymphoma - BJHNew prognostic index for Burkitt lymphoma - BJH
Burkitt lympohoma (BL) is a rare high-grade B-cell lymphoma, which in most cases is studied in small numbers. Definitions of ... New prognostic index for Burkitt lymphoma February 2021 Clinical practice Jeroen Beekwilder ... Burkitt Lymphoma International Prognostic Index. J Clin Oncol 2021; doi:10.1200/JCO.20.03288. ...
https://www.bjh.be/new-prognostic-index-for-burkitt-lymphoma/
Non-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, StagingNon-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, Staging
What studies are recommended by the NCCN to establish a diagnosis of the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ... What are the NCCN recommendations for follow-up in patients with the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ... What are the variants of the Burkitt lymphoma (BL) form of non-Hodgkin lymphoma (NHL) identified by the 2008 WHO classification ... What are the age and race risk factors for the Burkitt lymphoma form of non-Hodgkin lymphoma (NHL)? ...
https://www.medscape.com/answers/2500022-153211/what-are-the-survival-rates-of-the-follicular-lymphoma-type-of-non-hodgkin-lymphoma-nhl-based-on-the-flipi2-score
B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma) :: Peer Reviewed Pediatric Radiology Cases: :: The peer reviewed...
Sporadic Burkitt Lymphoma) Peer Reviewed Pediatric Radiology Cases ... B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma) B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). Dirk ... Sporadic Burkitt Lymphoma). Dirk Schaper, P G bel. B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). PedRad [serial ... Sporadic Burkitt Lymphoma). Dirk Schaper, P G bel. B-cell NHL of the Ileum (Type: Sporadic Burkitt Lymphoma). PedRad [serial ...
http://www.kinderradiologie-online.de/radiology/20051215115942.shtml
IMSEAR at SEARO: Burkitt's lymphoma.
IMSEAR is the collaborative product of Health Literature, Library and Information Services (HELLIS) Network Member Libraries in the WHO South-East Asia Region ...
https://imsear.searo.who.int/handle/123456789/6437
Burkitt's lymphoma
named after Denis Burkitt, 1911-93, British doctor, who first described it} ... Burkitts lymphoma - Bur·kitt s lymphoma .bər kəts also Burkitt lymphoma kət n a malignant lymphoma that affects primarily the ... Burkitts lymphoma - Infobox Disease Name = Burkitt s lymphoma Caption = Burkitt lymphoma, touch prep, Wright stain DiseasesDB ... Burkitts lymphoma - also Burkitt lymphoma noun Etymology: Denis Parsons Burkitt died 1993 British surgeon Date: 1963 a ...
https://australian_english.en-academic.com/15254/Burkitt%27s_lymphoma
Details for: Burkitt's lymphoma : › WHO HQ Library catalog
Burkitts lymphoma : a human cancer model, proceedings of a symposium held in Lyon, 6-98 December 1983 / organized by the IARC ... Burkitt lymphoma -- congresses , Noncommunicable DiseasesNLM classification: WH 525 Tags from this library: No tags from this ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=au%3A%22O%27Conor%2C%20G.%20T.%22%20and%20su-to%3ALymphoma&sort_by=relevance_dsc&count=20&limit=su-to:Burkitt%20lymphoma
Acute left ventricular insufficiency in a Burkitt Lymphoma patient with myocardial involvement and extensive local tumor cell...Acute left ventricular insufficiency in a Burkitt Lymphoma patient with myocardial involvement and extensive local tumor cell...
Myocardial lymphoma involvement receded completely during the following two therapy cycles, while cardiac function periodically ... Although rare, cardiac involvement in BL can quickly become life-threatening due to rapid lymphoma doubling time and should ... While additional studies are needed to further elucidate the mechanisms of acute cardiac insufficiency due to lymphoma lysis in ... Interestingly, the decline in cardiac function lessened with decreasing myocardial lymphoma manifestation. Once the ...
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-022-02480-5
About Us - Burkitts Lymphoma SocietyAbout Us - Burkitt's Lymphoma Society
Burkitts Like lymphoma, Burkitts lymphoma or Diffuse Large B-Cell lymphoma? * "You have Burkitts lymphoma, but it is one of ... Burkitts Lymphoma Society is a support and advocacy non-profit organization.. Burkitts lymphoma is a rare and aggressive form ... Burkitts Lymphoma Society. We are a support and advocacy non-profit organization for Burkitts Lymphoma patients and ... with encouraging insights only available from people who have been through the treatments for Burkitts lymphoma. ...
http://burkittslymphomasociety.com/about-us/
BLGSP - Foundation for Burkitt LymphomaBLGSP - Foundation for Burkitt Lymphoma
Burkitt Lymphoma Genome Sequencing Project. The Burkitt Lymphoma Genome Sequencing Project (BLGSP) is an ongoing multi-site, ... National Cancer Institute Office of Cancer Genomics as a public-private partnership with the Foundation for Burkitt Lymphoma ... may help to distinguish the anatomic and pathological differences in patients with endemic versus sporadic Burkitt Lymphoma. He ... How Results of the BLGSP Could Be Useful for Other Lymphoma and Cancers:. ...
https://www.foundationforburkittlymphoma.org/blgsp
B-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular LymphomaB-Cell Lymphoma Guidelines: Staging, Risk Stratification, Follicular Lymphoma
Non-Hodgkin lymphoma (NHL) is a collective term for a heterogeneous group of lymphoproliferative malignancies with differing ... Burkitt lymphoma. Normal architecture is entirely replaced by lymphoma cells and evenly dispersed macrophages, starry sky (250 ... of MCLs but is negative in all other B-cell lymphoid neoplasms except Burkitt lymphomas and lymphoblastic lymphomas ... Burkitt Lymphoma. Classification. The 2008 World Health Organization classification identifies the following three clinical ...
https://emedicine.medscape.com/article/202677-guidelines
Burkitt Lymphoma in Children | Northwestern MedicineBurkitt Lymphoma in Children | Northwestern Medicine
... fast-growing form of non-Hodgkin lymphoma (NHL). Its a type of cancer of the lymphatic system. The lymphatic system is part of ...
https://encyclopedia.nm.org/Conditions/Heart/Tools/160,2
BURKITT`S LYMPHOMA - English-Armenian Medical
Clinical and tomographic findings of Burkitts lymphoma in pediatric patients - case reportClinical and tomographic findings of Burkitt's lymphoma in pediatric patients - case report
Palavras-chave : Burkitt Lymphoma; Lymphoma Non-Hodgkin; Mouth Neoplasms.. · resumo em Português · texto em Português · pdf em ... Burkitts lymphoma is characterized as being a non-Hodgkins Lymphoma undifferentiated B cells with highly aggressive character ... In this paper we aim to report a case of Burkitts lymphoma in a child of 4 years old, explaining its clinical, tomographic and ... Clinical and tomographic findings of Burkitts lymphoma in pediatric patients - case report. Rev. cir. traumatol. buco-maxilo- ...
http://revodonto.bvsalud.org/scielo.php?script=sci_abstract&pid=S1808-52102015000200004&lng=pt&nrm=iso&tlng=en
Boy with Burkitt's lymphoma | Life on Earth Pictures
The boy suffers from Burkitts lymphoma, a cancer of the lymphatic system caused by the Epstein-Barr virus. ... Africa Tanzania health disease tropical disease woman African Tanzanian child boy non-Hodgkins lymphoma Burkitts lymphoma ... Boy with Burkitts lymphoma. Add to Cart Add to Lightbox Download Dr. Rina Luhaga examines Filbert Mabula as his mother Rahabu ... The boy suffers from Burkitts lymphoma, a cancer of the lymphatic system caused by the Epstein-Barr virus. ...
https://archive.lifeonearthpictures.com/image?&_bqG=72&_bqH=eJzLjQ9PisrwNncttCwLMsjNTA8o8yl3iq_MdrWwMjWysDI0MABhIOkZ7xLsbFuWWVRarAZmxzv6udiWANmhwa5B8Z4utqEgdU7BRUnlpll5VS7pavGOziG2xamJRckZAJ25IHI-&GI_ID=
Non Hodgkins, B-cell, Burkitts Lymphoma and me | robinbtaylorNon Hodgkins, B-cell, Burkitt's Lymphoma and me | robinbtaylor
HomeNon Hodgkins, B-cell, Burkitts Lymphoma and me Non Hodgkins, B-cell, Burkitts Lymphoma and me. December 22, 2014. June 3 ... 22 thoughts on "Non Hodgkins, B-cell, Burkitts Lymphoma and me" * Rosalind says: ... Non Hodgkins, B-cell, Burkitts lymphoma and me *Jump to the beginning ... Non Hodgkins, B-cell, Burkitts lymphoma and me *Jump to the beginning ...
https://robinbtaylor.com/2014/12/22/non-hodgkins-b-cell-burkett-lymphoma-and-me/?replytocom=856
true of BURKITT'S LYMPHOMA-UKMLA PLAB AMC USMLE Prometric MCQ
the following are true of BURKITTS LYMPHOMA. a) it is the commonest type of lymphoma in children b) histology demonstrates a ...
http://www.usmlemcq.com/2012/02/true-of-burkitt-lymphoma.html
Burkitt Lymphoma in Children | UCLA Health Library, Los Angeles, CABurkitt Lymphoma in Children | UCLA Health Library, Los Angeles, CA
... fast-growing form of non-Hodgkin lymphoma (NHL). Its a type of cancer of the lymphatic system. The lymphatic system is part of ...
https://healthinfo.uclahealth.org/Conditions/Pregnancy/160,2
BURKITTS LYMPHOMA - WHAT IS NEW? | Abinya | East African Medical JournalBURKITT'S LYMPHOMA - WHAT IS NEW? | Abinya | East African Medical Journal
Burkitt Lymphoma | Chemotherapy - treatment in Germany . Hospital Prices, Ranking, Reviews - BookinghealthBurkitt Lymphoma | Chemotherapy - treatment in Germany . Hospital Prices, Ranking, Reviews - Bookinghealth
Chemotherapy in Burkitt lymphoma - treatment in Germany ★ Direct prices from the best hospitals in Germany $ We will help you ... Burkitt Lymphoma - Chemotherapy: treatment in the Best Hospitals of Germany ➤Chemotherapy in Burkitt lymphoma - treatment in ... Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes ... Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, ...
https://bookinghealth.com/programs/treatment/hematology/aggressive-b-cell-lymphoma-burkitts-lymphoma-chemotherapy/germany
American Journal of Case Reports | Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level...American Journal of Case Reports | Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level...
CONCLUSIONS:Primary CNS Burkitt lymphoma (PCNSBL) is a rare disease with no clear evidence in the literature of how to deal ... Over the past years, only a few cases of primary CNS Burkitt lymphoma were reported. There is a challenge in early recognition ... We introduce a case of a 65-year-old who presented with fluctuating memory disturbance diagnosed as cerebral Burkitt lymphoma. ... Furthermore, there is no specific treatment protocols for primary CNS Burkitt lymphoma, which adds to the difficulty in ...
https://amjcaserep.com/abstract/related/idArt/936401

No FAQ available that match "burkitt lymphoma"

No images available that match "burkitt lymphoma"