Burkholderia mallei: A species of gram-negative bacteria parasitic on HORSES and DONKEYS causing GLANDERS, which can be transmitted to humans.Glanders: A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.Burkholderia: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.Burkholderia pseudomallei: A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.Burkholderia Infections: Infections with bacteria of the genus BURKHOLDERIA.Malleus: The largest of the auditory ossicles, and the one attached to the membrana tympani (TYMPANIC MEMBRANE). Its club-shaped head articulates with the INCUS.Melioidosis: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.Biological Warfare Agents: Living organisms or their toxic products that are used to cause disease or death of humans during WARFARE.Dourine: A disease of horses and donkeys caused by Trypanosoma equiperdum. The disease occurs in Africa, the Americas, and Asia.Burkholderia cepacia: A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.Burkholderia cepacia complex: A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.Burkholderia cenocepacia: A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.Horses: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.Carbon Cycle: The cycle by which the element carbon is exchanged between organic matter and the earth's physical environment.Chlorobi: A phylum of anoxygenic, phototrophic bacteria including the family Chlorobiaceae. They occur in aquatic sediments, sulfur springs, and hot springs and utilize reduced sulfur compounds instead of oxygen.Chlorobium: A genus of phototrophic, obligately anaerobic bacteria in the family Chlorobiaceae. They are found in hydrogen sulfide-containing mud and water environments.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Pentose Phosphate Pathway: An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Luminescence: Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.Security Measures: Regulations to assure protection of property and equipment.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.United States Government Agencies: Agencies of the FEDERAL GOVERNMENT of the United States.United States Office of Research Integrity: An office of the UNITED STATES PUBLIC HEALTH SERVICE organized in June 1992 to promote research integrity and investigate misconduct in research supported by the Public Health Service. It consolidates the Office of Scientific Integrity of the National Institutes of Health and the Office of Scientific Integrity Review in the Office of the Assistant Secretary for Health.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Whistleblowing: The reporting of observed or suspected PROFESSIONAL MISCONDUCT or incompetence to appropriate authorities or to the public.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Public Health Administration: Management of public health organizations or agencies.Administrative Personnel: Individuals responsible for the development of policy and supervision of the execution of plans and functional operations.Public Relations: Relations of an individual, association, organization, hospital, or corporation with the publics which it must take into consideration in carrying out its functions. Publics may include consumers, patients, pressure groups, departments, etc.Aptitude: The ability to acquire general or special types of knowledge or skill.Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins: SNARE binding proteins that facilitate the ATP hydrolysis-driven dissociation of the SNARE complex. They are required for the binding of N-ETHYLMALEIMIDE-SENSITIVE PROTEIN (NSF) to the SNARE complex which also stimulates the ATPASE activity of NSF. They are unrelated structurally to SNAP-25 PROTEIN.Local Government: Smallest political subdivisions within a country at which general governmental functions are carried-out.OregonPublic Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.State Health Plans: State plans prepared by the State Health Planning and Development Agencies which are made up from plans submitted by the Health Systems Agencies and subject to review and revision by the Statewide Health Coordinating Council.Public Health Practice: The activities and endeavors of the public health services in a community on any level.Communicable DiseasesCommunicable Disease Control: Programs of surveillance designed to prevent the transmission of disease by any means from person to person or from animal to man.Appendix: A worm-like blind tube extension from the CECUM.Science: The study of natural phenomena by observation, measurement, and experimentation.Influenza in Birds: Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.Public Opinion: The attitude of a significant portion of a population toward any given proposition, based upon a measurable amount of factual evidence, and involving some degree of reflection, analysis, and reasoning.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.2,2'-Dipyridyl: A reagent used for the determination of iron.Solar Energy: Energy transmitted from the sun in the form of electromagnetic radiation.Electrochemical Techniques: The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.Luminescent Measurements: Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.

Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. (1/86)

The object of this study was to develop and characterize experimental Burkholderia mallei aerosol infection in BALB/c mice. Sixty-five mice were infected with 5000 [approx. 2.5 median lethal doses (MLD)] B. mallei strain ATCC 23344(T) bacteria by the aerosol route. Bacterial counts within lung, liver, spleen, brain, kidney and blood over 14 days were determined and histopathological and immunocytochemical profiles were assessed. Mortality due to B. mallei infection occurred between days 4 and 10 post-infection. Bacterial numbers were consistently higher in the lungs than in other tissues, reaching a maximum of approximately 1.0 x 10(6) c.f.u. ml(-1) at 5 days post-infection. Bacterial counts in liver and spleen tissue remained approximately equal, reaching a maximum of approximately 1.0 x 10(4) c.f.u. ml(-1) at day 4 post-infection. By day 14 post-infection, bacterial counts were in the range 1.0 x 10(3)-1.0 x 10(4) c.f.u. ml(-1) for all tissues. Infection of the lungs by B. mallei resulted in foci of acute inflammation and necrosis. As infection progressed, the inflammatory process became subacute or chronic; this was associated with the development of extensive consolidation. Lesions in liver and spleen tissue were typical of those that might be expected in bacteraemia or bacterial toxaemia. These results suggest that the BALB/c mouse is susceptible to B. mallei when delivered by the aerosol route and that this represents a model system of acute human glanders that is suitable for research into the pathogenesis of and vaccines against this disease.  (+info)

Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei. (2/86)

By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.  (+info)

Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b. (3/86)

Burkholderia pseudomallei is the etiologic agent of the disease melioidosis and is a category B biological threat agent. The genomic sequence of B. pseudomallei K96243 was recently determined, but little is known about the overall genetic diversity of this species. Suppression subtractive hybridization was employed to assess the genetic variability between two distinct clinical isolates of B. pseudomallei, 1026b and K96243. Numerous mobile genetic elements, including a temperate bacteriophage designated phi1026b, were identified among the 1026b-specific suppression subtractive hybridization products. Bacteriophage phi1026b was spontaneously produced by 1026b, and it had a restricted host range, infecting only Burkholderia mallei. It possessed a noncontractile tail, an isometric head, and a linear 54,865-bp genome. The mosaic nature of the phi1026b genome was revealed by comparison with bacteriophage phiE125, a B. mallei-specific bacteriophage produced by Burkholderia thailandensis. The phi1026b genes for DNA packaging, tail morphogenesis, host lysis, integration, and DNA replication were nearly identical to the corresponding genes in phiE125. On the other hand, phi1026b genes involved in head morphogenesis were similar to head morphogenesis genes encoded by Pseudomonas putida and Pseudomonas aeruginosa bacteriophages. Consistent with this observation, immunogold electron microscopy demonstrated that polyclonal antiserum against phiE125 reacted with the tail of phi1026b but not with the head. The results presented here suggest that B. pseudomallei strains are genetically heterogeneous and that bacteriophages are major contributors to the genomic diversity of this species. The bacteriophage characterized in this study may be a useful diagnostic tool for differentiating B. pseudomallei and B. mallei, two closely related biological threat agents.  (+info)

Contribution of gene loss to the pathogenic evolution of Burkholderia pseudomallei and Burkholderia mallei. (4/86)

Burkholderia pseudomallei is the causative agent of melioidosis. Burkholderia thailandensis is a closely related species that can readily utilize l-arabinose as a sole carbon source, whereas B. pseudomallei cannot. We used Tn5-OT182 mutagenesis to isolate an arabinose-negative mutant of B. thailandensis. Sequence analysis of regions flanking the transposon insertion revealed the presence of an arabinose assimilation operon consisting of nine genes. Analysis of the B. pseudomallei chromosome showed a deletion of the operon from this organism. This deletion was detected in all B. pseudomallei and Burkholderia mallei strains investigated. We cloned the B. thailandensis E264 arabinose assimilation operon and introduced the entire operon into the chromosome of B. pseudomallei 406e via homologous recombination. The resultant strain, B. pseudomallei SZ5028, was able to utilize l-arabinose as a sole carbon source. Strain SZ5028 had a significantly higher 50% lethal dose for Syrian hamsters compared to the parent strain 406e. Microarray analysis revealed that a number of genes in a type III secretion system were down-regulated in strain SZ5028 when cells were grown in l-arabinose, suggesting a regulatory role for l-arabinose or a metabolite of l-arabinose. These results suggest that the ability to metabolize l-arabinose reduces the virulence of B. pseudomallei and that the genes encoding arabinose assimilation may be considered antivirulence genes. The increase in virulence associated with the loss of these genes may have provided a selective advantage for B. pseudomallei as these organisms adapted to survival in animal hosts.  (+info)

Structural flexibility in the Burkholderia mallei genome. (5/86)

The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei, the etiologic agent of glanders, has come under renewed scientific investigation as a result of recent concerns about its past and potential future use as a biological weapon. Genome analysis identified a number of putative virulence factors whose function was supported by comparative genome hybridization and expression profiling of the bacterium in hamster liver in vivo. The genome contains numerous insertion sequence elements that have mediated extensive deletions and rearrangements of the genome relative to Burkholderia pseudomallei. The genome also contains a vast number (>12,000) of simple sequence repeats. Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a B. mallei infection.  (+info)

Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei. (6/86)

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC 23344 genome revealed that it encodes at least two luxI and four luxR homologues. Using mass spectrometry, we showed that wild-type B. mallei produces the signaling molecules N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone. To determine if QS is involved in the virulence of B. mallei, we generated mutations in each putative luxIR homologue and tested the pathogenicities of the derivative strains in aerosol BALB/c mouse and intraperitoneal hamster models. Disruption of the B. mallei QS alleles, especially in RJ16 (bmaII) and RJ17 (bmaI3), which are luxI mutants, significantly reduced virulence, as indicated by the survival of mice who were aerosolized with 10(4) CFU (10 50% lethal doses [LD50s]). For the B. mallei transcriptional regulator mutants (luxR homologues), mutation of the bmaR5 allele resulted in the most pronounced decrease in virulence, with 100% of the challenged animals surviving a dose of 10 LD50s. Using a Syrian hamster intraperitoneal model of infection, we determined the LD50s for wild-type B. mallei and each QS mutant. An increase in the relative LD50 was found for RJ16 (bmaI1) (>967 CFU), RJ17 (bmaI3) (115 CFU), and RJ20 (bmaR5) (151 CFU) compared to wild-type B. mallei (<13 CFU). These findings demonstrate that B. mallei carries multiple luxIR homologues that either directly or indirectly regulate the biosynthesis of an essential virulence factor(s) that contributes to the pathogenicity of B. mallei in vivo.  (+info)

Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. (7/86)

OBJECTIVES: Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria. METHODS: MICs were determined by agar dilution in Mueller-Hinton medium. RESULTS: Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem. CONCLUSIONS: Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections.  (+info)

Identification and discrimination of Burkholderia pseudomallei, B. mallei, and B. thailandensis by real-time PCR targeting type III secretion system genes. (8/86)

Burkholderia pseudomallei and B. mallei are two highly pathogenic bacteria, responsible for melioidosis and glanders, respectively. The two are closely related and can also be mistaken for B. thailandensis, a nonpathogenic species. To improve their differential identification, we describe a hydrolysis probe-based real-time PCR method using the uneven distribution of type III secretion system genes among these three species.  (+info)

*List of sequenced bacterial genomes

2004). "Structural flexibility in the Burkholderia mallei genome". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14246-51. Bibcode: ...

*Melioidosis

It is phylogenetically related closely to Burkholderia mallei which causes glanders, an infection primarily of horses, donkeys ... 2008). "Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei". Emerging Infectious Diseases ... 2011). "Burkholderia multivorans acts as an antagonist against the growth of Burkholderia pseudomallei in soil". Microbiology ... 2005). "Comparison of Ashdown's Medium, Burkholderia cepacia Medium, and Burkholderia pseudomallei Selective Agar for Clinical ...

*Zoonosis

Burkholderia mallei. horses, donkeys direct contact Gnathostomiasis Gnathostoma spp. dogs, minks, opossums, cats, lions, tigers ... Burkholderia pseudomallei various animals direct contact with contaminated soil and surface water ...

*Zoonosis

Burkholderia mallei.. horses, donkeys. direct contact. Hantavirus. Hantavirus spp.. deer mice, cotton rats and other rodents. ...

*Burkholderiaceae

It includes some pathogenic species, such as Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis). ... to accommodate twelve species of the genera Burkholderia and Paraburkholderia". International Journal of Systematic and ... Dobritsa, AP; Samadpour, M (August 2016). "Transfer of eleven species of the genus Burkholderia to the genus Paraburkholderia ...

*Trimethoprim/sulfamethoxazole

Burkholderia cepacia Burkholderia mallei (glanders) Burkholderia pseudomallei (melioidosis) Chlamydia trachomatis (chlamydia) ...

*Pus

Burkholderia mallei (Glanders bacillus). *Mycobacterium tuberculosis (tubercle bacillus). Staphylococcus aureus bacteria is the ...

*Alfred Whitmore

He differentiated it from Burkholderia mallei, the causative agent of glanders, by clinical and microbiological features. He ... Major Alfred Whitmore (1876-1946) was an English pathologist who, together with C.S. Krishnaswami, identified Burkholderia ...

*Mallein test

It is caused by a bacterium called Burkholderia mallei, which is contagious for humans and other species. The occurrence of ... cross reactions were reported between Burkholderia mallei and Streptococcus equi, which is a bacteria-caused contagious upper ... Mallein, a protein fraction of B. mallei, is usually injected by an eye-drop. If an animal is infected, the animal will show ... precipitation Gel filtration chromatography Sensitization of animals Potency test Intradermopalpebral Burkholderia mallei ...

*Glanders

It is caused by infection with the bacterium Burkholderia mallei, usually by ingestion of contaminated feed or water. Signs of ... B. mallei is able to infect humans, so is classed as a zoonotic agent. Transmission occurs by direct contact with infected ... Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is ... Between 1982 and 1984, the Soviet Union allegedly used weaponized B. mallei during the Soviet-Afghan War. Before the Battle of ...

*Septic shock

Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei ...

*Lipid A

Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei ...

*Liosta de ghalair thógálacha - Vicipéid

Burkholderia mallei. Gnathostomiasis. Gnathostoma spinigerum and Gnathostoma hispidum. Gonorrhea. Neisseria gonorrhoeae. ...

*Emerging infectious disease

Burkholderia pseudomallei (melioidosis) Burkholderia mallei (glanders) Coxiella burnetii (Q fever) Epsilon toxin of Clostridium ...

*Pathema

Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens, and Entamoeba histolytica) involved in new and re- ...

*Biosecurity in the United States

... formerly Pseudomonas mallei) Burkholderia pseudomallei (formerly Pseudomonas pseudomallei) Clostridium perfringens epsilon ... Botulinum neurotoxin producing species of Clostridium Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei ( ...

*Anton Dilger

DC in which cultures of the causative agents of anthrax and glanders-Bacillus anthracis and Burkholderia mallei-were produced. ...

*List of clinically important bacteria

Brucella abortus Brucella melitensis Brucella suis Burkholderia Burkholderia mallei Burkholderia pseudomallei Burkholderia ...

*Select agent

Coxiella burnetii Burkholderia mallei* (formerly Pseudomonas mallei) Burkholderia pseudomallei* (formerly Pseudomonas ... Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei* (formerly Pseudomonas mallei) Burkholderia pseudomallei ...

*Unit 100

The following potential agents were tested:[citation needed] Yersinia pestis, which causes plague Burkholderia mallei, which ...

*Soviet biological weapons program

Burkholderia mallei (glanders) Brucella spp (brucellosis) Coxiella burnetii (Q-fever) Venezuelan equine encephalitis virus (VEE ...

*Pus

Pseudomonas aeruginosa Neisseria gonorrhoeae Actinomyces Burkholderia mallei (Glanders bacillus) Mycobacterium tuberculosis ( ...

*Burkholderia

... glathei Burkholderia glumae Burkholderia grimmiae Burkholderia humi Burkholderia lata Burkholderia latens Burkholderia mallei ... Burkholderia ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia cepacia Burkholderia ... Burkholderia cocovenenans Burkholderia contaminans Burkholderia diffusa Burkholderia dolosa Burkholderia gladioli Burkholderia ... Burkholderia stabilis Burkholderia stagnalis Burkholderia telluris Burkholderia terrestris Burkholderia territorii Burkholderia ...

*Burkholderia pseudomallei

2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ... October 2005). "Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450. ... Burkholderia thailandensis) and arabinose-negative Burkholderia pseudomallei". Microbiology and immunology. 43 (7): 625-30. doi ...

*Burkholderia mallei

... is a Gram-negative, bipolar, aerobic bacterium, a Burkholderia-genus human and animal pathogen causing ... B. mallei's genome also has a large amount of insertion sequences. B. mallei was first called "Bacillus mallei" and was in the ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ...

*Septic shock

Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei ...

*Urinary tract infection

Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...

*Cholera

Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
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Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
ID BURM7_2_PE1705 STANDARD; PRT; 480 AA. AC BURM7_2_PE1705; A3MMD6; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Drug resistance transporter, EmrB/QacA subfamily; DE (BURM7_2.PE1705). GN OrderedLocusNames=BMA10247_1885; OS BURKHOLDERIA MALLEI NCTC 10247. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=320389; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BURM7_2.PE1705. CC Burkholderia mallei NCTC 10247 chromosome I, complete genome. CC sequence. CC -!- ANNOTATIONS ORIGIN:A3MMD6_BURM7 CC -!- GENE_FAMILY: HOG000239124 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; A3MMD6; -. DR EMBL; CP000548; ABO05294.1; -; Genomic_DNA. DR RefSeq; YP_001081422.1; NC_009080.1. DR ProteinModelPortal; A3MMD6; -. DR STRING; A3MMD6; -. DR GeneID; 4893681; -. DR GenomeReviews; CP000548_GR; ...
ID BURMS_2_PE2987 STANDARD; PRT; 610 AA. AC BURMS_2_PE2987; A1V7Z1; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Glucosamine--fructose-6-phosphate aminotransferase, DE isomerizing; EC=2.6.1 16; (BURMS_2.PE2987). GN Name=glmS-2; OrderedLocusNames=BMASAVP1_A3050; OS BURKHOLDERIA MALLEI SAVP1. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=320388; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BURMS_2.PE2987. CC Burkholderia mallei SAVP1 chromosome I, complete genome. CC sequence. CC -!- ANNOTATIONS ORIGIN:A1V7Z1_BURMS CC -!- GENE_FAMILY: HOG000258898 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; A1V7Z1; -. DR EMBL; CP000526; ABM52310.1; -; Genomic_DNA. DR RefSeq; YP_994344.1; NC_008785.1. DR ProteinModelPortal; A1V7Z1; -. DR SMR; A1V7Z1; 2-610. DR STRING; A1V7Z1; -. DR ...
Carbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excluding a cofactor (CoA, CoM, THF, or THMPT) that is replaced by an asterisk. The map contains carbon utilization pathways of glycolysis (map00010), pentose phosphate pathway (map00030), and citrate cycle (map00020), and six known carbon fixation pathways (map00710 and map00720) as well as some pathways of methane metabolism (map00680). The six carbon fixation pathways are: (1) reductive pentose phosphate cycle (Calvin cycle) in plants and cyanobacteria that perform oxygenic photosynthesis, (2) reductive citrate cycle in photosynthetic green sulfur bacteria and some chemolithoautotrophs, (3) 3-hydroxypropionate bi-cycle in photosynthetic green nonsulfur bacteria, two variants of 4-hydroxybutyrate pathways in Crenarchaeota called (4) hydroxypropionate-hydroxybutyrate cycle and (5) ...
Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective therapeutic treatments are lacking. In this study, we showed that CpG administration increased survival, demonstrating protection in the murine glanders model. Bacterial recovery from infected lungs, liver and spleen was significantly reduced in CpG-treated animals as compared with non-treated mice. Reciprocally, lungs of CpG-treated infected animals were infiltrated with higher levels of neutrophils and inflammatory monocytes, as compared to control animals. Employing the B. mallei bioluminescent strain CSM001 and the Neutrophil-Specific Fluorescent Imaging Agent, bacterial dissemination and neutrophil trafficking were monitored in real-time using multimodal in vivo whole body imaging techniques. CpG-treatment increased recruitment of neutrophils to the lungs and reduced bioluminescent bacteria, correlating with decreased bacterial burden and increased protection against acute
Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram - negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. This Phase II SBIR project will build on the success of our Phase I work, which established methods for generating monoclon .... ...
Dr. Gelhaus is Senior Program Manager in the Medical Countermeasures Division of MRIGlobal, where he directs cutting edge research to protect the world from biological threats.. Dr. Gelhaus is also an adjunct faculty member at KCU. Dr. Gelhaus has 19 years of experience in the field of immunology, covering a diverse range of topics. Dr. Gelhaus has nine years of experience in infectious disease, with emphasis on bioweapons and bioterror threats.. At the United States Army Research Institute of Infectious Diseases (USAMRIID), Dr. Gelhaus performed research on the role of toll-like receptors (TLR) involved in the pathogenesis of diseases caused by gram-negative select agent bacteria, namely, Burkholderia mallei, Burkholderia pseudomallei, Francisella tularensis and Yersinia pestis.. At Battelle, Dr. Gelhaus was involved in the development of animal models as a Study Director for Good Laboratory Practices regulated studies, including supporting licensure of medical countermeasures through the US ...
Wallqvist, A., H. Wang, N. Zavaljevski, V. Memisevic, K. Kwon, R. Pieper, S. V. Rajagopala, and J. Reifman. Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions. PLOS ONE. 2017 November 27; 12(11):e0188071. [PDF]. Memisevic, V., K. Kumar, N. Zavaljevski, D. DeShazer, A. Wallqvist, and J. Reifman. DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems. BMC Bioinformatics. 2016 September 20; 17:387. [PDF]. Wallqvist, A., V. Memisevic, N. Zavaljevski, R. Pieper, S. V. Rajagopala, K. Kwon, C. Yu, T. A. Hoover, and J. Reifman. Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors. BMC Genomics. 2015 December 29; 16:1106. [PDF]. Chiang, C. Y., I. Uzoma, D. J. Lane, V. Memisevic, F. Alem, K. Yao, S. Bavari, A. Wallqvist, R. M. Hakami, and R. G. Panchal. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. ...
A simple method was developed for detection and differentiation of five Tier 1 bacterial agents, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, Burkholderia pseudomallei and Burkholderia mallei as well as their closely related near neighbors by gas chromatography-mass spectrometry (GC-MS). Generally, different classes of compounds can be used as biomarkers for biowarfare agent detection, including nucleic acids (i.e., DNA or RNA), proteins (i.e., antibodies), carbohydrates (i.e., sugars), lipopolysaccharides, lipids (i.e., fatty acids) and small molecules. One-step thermochemolysis (TCM) was developed to provide GC-MS detectable biomarker signatures, including sugars, fatty acids and small molecules. Solid phase micro-extraction (SPME) was used for biomarker extraction, concentration and introduction into the GC-MS. Statistical algorithms were constructed using a combination of biomarkers for the five agents, which were robust against different growth conditions (medium and
malleus definition: The hammer-shaped bone tissue this is the outermost for the three small bones inside mammalian center ear. Also known as hammer.; The small hammer-shaped bone of this center ear.;…
Improvement of number of HIV-RNA copies; Improvement is measured by general evaluation of decrease in HIV-RNA copies.. Improvement of CD4 counts; Improvement is measured by general evaluation of increase in CD4 counts.. Not progress in HIV classification (severity of CDC category); Subjects were classified based on the severity of CDC category as mild (Category A), moderate (Category B), and severe (Category C). No change categories from Category A to Category B / Category C, or from Category B to Category C in CDC category. ...
Come to our booth 67a and learn how our customers have used Applied Biosystems™ TaqMan™ array cards for the detection of respiratory viruses and antibiotic resistance genes. Move your single-plex Applied Biosystems™ TaqMan™ assays for microbial identification to the next level using our Custom Formatting Services. It offers the convenience of TaqMan assays pre-plated according to your specifications. Just tell us how you want to configure your plate or card and we will manufacture it.. Discover more. ...
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Before taking Prevacid, tell your doctor if you ever have liver disease. You may not be able to take Prevacid, or you may require a dosage adjustment or special monitoring during treatment. Prevacid is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Prevacid without first talking to your doctor if you are pregnant. It is not known whether Prevacid passes into breast milk. Do not take Prevacid without first talking to your doctor if you are breast-feeding a baby ...
Doctors give unbiased, trusted information on whether Emetrol can cause or treat Pregnancy: Dr. Warren on is it safe to take emetrol if you are pregnant: if the benefits out weight the risks and you need it you can take it check with your OB provider to see if you need it or whether you can be off of it during your pregnancy There are different reasons for taking it and you need to see the provider
Before taking Prevacid, tell your doctor if you ever have liver disease. You may not be able to take Prevacid, or you may require a dosage adjustment or special monitoring during treatment. Prevacid is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Prevacid without first talking to your doctor if you are pregnant. It is not known whether Prevacid passes into breast milk. Do not take Prevacid without first talking to your doctor if you are breast-feeding a baby ...
Glanders is a serious zoonotic disease that primarily affects equids (horses, mules and donkeys). A disease eradication programme based on case detection and destruction of infected domestic animals has been highly successful and the number of reported glanders cases in animals worldwide is now very low. Human glanders is extremely rare and associated with occupations associated with extensive contact with equids. Glanders is caused by Burkholderia mallei, a Gram-negative, non-motile, facultative intracellular organism that is an obligate parasite of equids with no other known natural reservoir. B. mallei is transmitted by direct contact with infected animals, or indirectly via communal food and water sources that have become contaminated by an infected animal. The clinical presentation in equids can be acute or chronic and has been categorized into nasal, pulmonary and cutaneous forms. Diagnosis is based on culturing B. mallei from lesions or exudates and skin or serological testing. Infected ...
Glanders (from Middle English glaundres or Old French glandres, both meaning glands) (Latin: malleus German: Rotz) (also known as "equinia," "farcy," and "malleus") is an infectious disease that occurs primarily in horses, mules, and donkeys. It can be contracted by other animals, such as dogs, cats and goats. It is caused by infection with the bacterium Burkholderia mallei, usually by ingestion of contaminated food or water. Signs of glanders include the formation of nodular lesions in the lungs and ulceration of the mucous membranes in the upper respiratory tract. The acute form results in coughing, fever, and the release of an infectious nasal discharge, followed by septicaemia and death within days. In the chronic form, nasal and subcutaneous nodules develop, eventually ulcerating. Death can occur within months, while survivors act as carriers.. Glanders is endemic in Africa, Asia, the Middle East, and Central and South America. It has been eradicated from North America, Australia, and most ...
The mallein test is a sensitive and specific clinical test for glanders, a common bacterial disease of equids (horses, donkeys, mules). This test is an allergic hypersensitivity test used as a diagnosis for glanders. It is caused by a bacterium called Burkholderia mallei, which is contagious for humans and other species. The occurrence of glanders must be reported to the World Organisation for Animal Health. Mallein, a protein fraction of B. mallei, is usually injected by an eye-drop. If an animal is infected, the animal will show swelling in the eye from around 48 hours of injection and may be accompanied by secretion and conjunctivitis. Mallein is non toxic to normal animals. Mallein was discovered in 1890. Before 1934, glanders was widespread. In the early 1900s, glanders was common in Europe, the United States of America, and Canada, and has been successfully eliminated by mass testing and the slaughter and destruction of campaigns. Glanders is still present in Asia, the Middle East and ...
Animal Health Australia. The National Animal Health Information System [NAHIS]. Glanders [online]. NAHIS; 2001 Oct. Available at: http://www.brs.gov.au/usr-bin/aphb/ahsq?dislist=alpha.* Accessed 4 Oct 2002.. Rega PP. CBRNE - Glanders and melioidosis. eMedicine [online]; 2007 Aug. Available at: http://www.emedicine.com/emerg/topic884.htm. Accessed 27 Aug 2007.. Bauernfeind A, Roller C, Meyer D, Jungwirth R, Schneider I. Molecular procedure for rapid detection of Burkholderia mallei and Burkholderia pseudomallei. J Clin Microbiol. 1998;36: 2737-2741.. Biberstein EL, Holzworth J. In: Holzworth J, editor. Diseases of the cat. Philadelphia: WB Saunders; 1987. Bacterial diseases: Glanders; p. 296.. Bossi P, Tegnell A, Baka A, Van Loock F, Hendriks J, Werner A, Maidhof H, Gouvras G; Task Force on Biological and Chemical Agent Threats, Public Health Directorate, European Commission, Luxembourg. Bichat guidelines for the clinical management of glanders and melioidosis and bioterrorism-related glanders ...
Looking for online definition of slender process of malleus in the Medical Dictionary? slender process of malleus explanation free. What is slender process of malleus? Meaning of slender process of malleus medical term. What does slender process of malleus mean?
Disease Ontology : 12 A primary bacterial infectious disease that results_in septicemic infection, has material basis in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs ...
Epitope curation should be conducted in the following priority order: A) NIAID Category A, B, and C priority pathogens and toxins: The complete list of NIAID Category A, B, and C priority pathogens and toxins can be found at the following URL: http://www2.niaid.nih.gov/biodefense/bandc_priority.htm. NIAID - Category A Bacillus anthracis (anthrax) Clostridium botulinum Yersinia pestis Variola major (smallpox) and other pox viruses Francisella tularensis (tularemia) Viral hemorrhagic fevers Arenaviruses LCM, Junin virus, Machupo virus, Guanarito virus Lassa Fever Bunyaviruses Hantaviruses Rift Valley Fever Flaviruses Dengue Filoviruses Ebola Marburg NIAID - Category B Burkholderia pseudomallei Coxiella burnetii (Q fever) Brucella species (brucellosis) Burkholderia mallei (glanders) Ricin toxin (from Ricinus communis) Epsilon toxin of Clostridium perfringens Staphylococcus enterotoxin B Typhus fever (Rickettsia prowazekii) Food and Waterborne Pathogens Bacteria Diarrheagenic E.coli Pathogenic ...
The Soviet Union began a biological weapons program in the 1920s. During World War II, Joseph Stalin was forced to move his biological warfare (BW) operations out of the path of advancing German forces and may have used tularemia against German troops in 1942 near Stalingrad. By 1960, numerous BW research facilities existed throughout the Soviet Union. Although the USSR also signed the 1972 Biological Weapons Convention (BWC), the Soviets subsequently augmented their biowarfare programs. Over the course of its history, the Soviet program is known to have weaponized and stockpiled the following eleven bio-agents (and to have pursued basic research on many more): Bacillus anthracis (anthrax) Yersinia pestis (plague) Francisella tularensis (tularemia) Burkholderia mallei (glanders) Brucella spp (brucellosis) Coxiella burnetii (Q-fever) Venezuelan equine encephalitis virus (VEE) Botulinum toxin (botulism) Staphylococcal enterotoxin B Smallpox Marburg virus These programs became immense and were ...
Define glanders: a highly contagious and life-threatening disease of horses and other equines (such as donkeys and mules) or sometimes other animals …
Based on these results, we conclude Selleck Ro 61-8048 that BoaA is a well-conserved gene product shared by B. mallei and B. pseudomallei. Table 2 Percent identity shared by boaA and boaB gene products BoaA (Bm ATCC23344) BoaA (Bm NCTC10247) BoaA (Bp K96243) BoaA (Bp DD503) BoaA (Bp 1710b) BoaB (Bp K96243) BoaB (Bp DD503) BoaB (Bp 1710b) BoaA (Bm ATCC23344) 100 BoaA (Bm NCTC10247) 86.9 100 BoaA (Bp K96243) 92.7 89.2 100 BoaA (Bp DD503) 94.4 82.2 90.6 100 BoaA (Bp 1710b) 90.4 83.1 92.4 93.6 100 BoaB (Bp K96243) 64 60 65 63.9 63.9 100 BoaB (Bp. DD503) 62 60.8 62.9 61.9 62.2 96.7 100 BoaB (Bp 1710b) 62.2 60.9 63.2 62.1 62.4 97 99.7 100 Bm = B. mallei Bp = B. pseudomallei Identification of a B. pseudomallei-specific gene encoding a putative autotransporter adhesin that resembles BoaA Further analysis of the annotated genomic sequence of B. pseudomallei K96243 identified the ORF locus tag number BPSL1705 as specifying a second Oca-like protein that is ~60% identical to BoaA. The last 776 aa of ...
In the later sixties it became apparent to the elite with the responsibilities for "control of the population" that the old idea of putting people in the proverbial bin and keeping them there for life - warehousing people - wasnt cost-effective. The Reagan administration in California was one of the first to realize this. So they had to rethink just what is said to the general public and what is practiced by the executive in control of mental health. The same problem prevails across Europe and the Third World. To see what is happening, look at the textbook or manual called DSM-III: The Diagnostic Statistical Manual on Mental Disorders. Translated into economic and political terms, mental disorder means undesired mental states and behavior. The criteria for mental disorder in DSM-III include any unusual perceptual experience, magical thinking, clairvoyance, telepathy, sixth sense, sense of a person not actually present. Youre allowed to sense the presence of a dead relative for three weeks ...
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Conflicting evidence exists on the prognostic value of PES in BS,4,14,15⇓⇓ and no other predictors of adverse outcome are available. A consensus exists on the indication of an ICD in cardiac arrest survivors,16,17⇓ yet treatment of the majority of patients with BS is undefined.. We have assessed in our population the validity of the stratification scheme proposed by Brugada et al,18 who divided patients into 4 groups, based on clinical features and inducibility at PES (categories A to D). We observed 1 of 14 events in category D (7% of cardiac arrest) and 3 of 35 events in category C (8% of cardiac arrest): Brugada et al18 recommend no ICD in category D and ICD implantation in category C; obviously, our data cannot endorse this recommendation. When category A and category B are compared, no differences are observed (33% of events in category B and 30% of events in category A).. We therefore explored the value of several clinical parameters to differentiate between patients with and without ...
Like the Malleus Malleficarum , the Diagnostic and Statistical Manual. (American ... criteria for identifying people who are seen as abnormal. It codifies ... the existence of mental disorders is an essential part of the psychiatric faith. .... disorder. The satisfied before making a diagnosis first time. Homosexuality ... the best from. ...
Hanson JR. and Anson BJ. Development of the malleus of the human ear; Illustrated in atlas series. (1962) Q Bull Northwest Univ Med Sch. 36(2): 119-137. PMID: 13904457. ...
Thursday, March 30, 1939 E-GAZETTE MASON CITY GLOBE-GAZETTE COMPANX Telephone No. 3800 L9, 0 KrP U *» DAI1 ^Y SCRAP BOOK By Scott EYE Enlerea us second-class mallei April 17. 1930. al Ule Bost . oa.ceat ilMDD City. Iowa. ,,,,;,, the act a! Jl. Edition of The Mason City Globe-Gazette
This survey investigated the variation in the use of the breast core biopsy categories B1 normal and B2 benign. METHOD: A survey with case scenarios was circulated to 701 breast pathologists in the UK. RESULTS: The response ...
As this eMedTV page explains, Natroba is a pregnancy Category B drug, which means it is unlikely to affect the fetus. This article discusses the drugs use during pregnancy, explaining why very little of it is expected to reach the bloodstream.
FDA pregnancy category B. Periactin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Periactin passes into breast milk, but if it does it could harm a nursing baby. Do not use this medication while you are breast-feeding a baby. Do not give Periactin to a child younger 2 years. Older adults may be more likely to have side effects from Periactin.. ...
The etiologic agent of human and animal melioidosis is Burkholderia pseudomallei (5, 17). Both B. pseudomallei and its close species relative Burkholderia mallei are microbes recognized as having the potential for misuse as biological weapons (1). Typically, signs of pneumonia in patients with clinical melioidosis are a secondary result of sepsis (5). Presumably, victims suffering from a biological attack that employed B. pseudomallei or B. mallei would present clinically with pneumonic disease as the initial aspect. In order to develop a vaccine program for defending U.S. military forces against a potential B. mallei or B. pseudomallei attack, whole-body aerosol laboratory models of disease were established. With these murine melioidosis models, future vaccine candidates can be evaluated and tested for efficacy.. B. pseudomallei strain 1026b was selected because of its ease of genetic manipulation, its ability to replace genes, and its previously characterized virulence (6, 17). The 50% lethal ...
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
A pathological condition, aural atresia, was discovered associated with human remains recovered from a late 19th-century Catholic cemetery 2 km south of Battleford, Saskatchewan, Canada. Aural atresia, a congenital condition that results in a non-existent external auditory meatus, was apparent on the right temporal bone of the remains of a young adult male. A complete osteological and contextual assessment, which included the use of a SkyScan 1172 micro-CT scanner on the pathological incus that was recovered, indicated that the right incus and malleus had fused during early embryological development. The artifacts associated with this individual included a pocket mirror that may have represented a connection to the practice of oralism due to the discouragement of sign language by the authorities in that time period. The combination of advanced bone imaging and a complete contextual analysis suggests a differential diagnosis of nonfunctional hearing associated with the right ear, and the ...
malleus. // Tabers Cyclopedic Medical Dictionary;2005, p1297 A definition of the term "Malleus" is presented. It refers to the largest of the three auditory ossicles in the middle ear. Malleus is attached to the eardrum and articulates with the incus. The definition is from the "Tabers Cyclopedic Medical Dictionary," published by F.A. Davis Co. ...
Lowe, W., J.K. March, A.J. Bunnell, K.L. ONeill, and R.A. Robison. 2013. PCR-based methodologies used to detect and differentiate the Burkholderia pseudomallei complex: B. pseudomallei, B. mallei, and B. thailandensis. Current Issues in Molecular Biology 16: 23-54.. Gunnell, M.K., Adams, B.J., and Robison, R.A. 2015. The genetic diversity and evolution of Francisella tularensis with comments on detection by PCR. Current Issues in Molecular Biology. 18: 79-92.. Gunnell, M.K., Robison, R.A., and Adams, B.J. 2016. Natural selection in virulence genes of Francisella tularensis. Journal of Molecular Evolution. DOI 10.1007/s00239-016-9743-y, 1-15.. Lowe, C-W, Satterfield, B.A., Nelson, D.B., Thiriot, J.D., Heder, M.J., March, J.K., Drake, D.S., Lew, C.S., Bunnell, A.J., Moore, E.S., ONeill, K.L., and Robison, R.A. 2016. A quaduplex real-time assay for the rapid detection and differentiation of the most relevant members of the B. pseudomallei complex: B. mallei, B. pseudomallei, and B. thailandensis. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Teheran zoo has reportedly killed 14 lions infected with the rare bacterial disease glanders. Earlier, an Amur tiger delivered from Russia as part of a breeding program died in Iran, with glanders among one of the suspected reasons.
Twenty years ago the shuttle Exallon came within the restricted zone of the Humerus and was escorted to the Castellanus by a detachment of Thunderhawks on duty. The crew of the Exallon was held in the infirmary for questioning many months following their infringement. They all had severe burns on most parts of their bodies and the medical staff could do little to assist the Adeptus Arbites in keeping them at a level of conscience, sufficient to conclude the interrogation. The last one of them passed away after nine days.. A warden of the medical facility, named Karrack Bor, claimed to have seen writings on one of their bodies, which told tales of powerful creatures rewarding worship. Compelled by these tales he began massing followers in the months following the crews death by recounting these tales. Exactly three years, three months and three days after the death of the last crewman he led minor revolt in the Prytaneum. The rebels sought access to the Naxes Sector, but armed only with small ...
As the incus (Latin for anvil) does bear a striking resemblance to anvils going back to ancient Rome, youd be justified in assuming that the naming of the malleus was inspired by the blacksmiths hammer. Indeed, the bone does have a long handle and a head that articulates with the incus, just as the hammer of a blacksmith should. However, it resembles not the hammer of the smithy but the hammer of the priest, used to stun oxen prior to sacrifice; butchers used it too. This tool was large and heavy, requiring two hands and not an obvious inspiration for the name of one of the smallest bones of the body. However, it had a distinctively round head like that of the ossicle and thus the bone was so designated as the malleus. ...
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FDA pregnancy category B. Periactin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Periactin passes into breast milk, but if it does it could harm a nursing baby. Do not use this medication while you are breast-feeding a baby. Do not give Periactin to a child younger 2 years. Older adults may be more likely to have side effects from Periactin.. ...
FDA pregnancy category B. Periactin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Periactin passes into breast milk, but if it does it could harm a nursing baby. Do not use this medication while you are breast-feeding a baby. Do not give Periactin to a child younger 2 years. Older adults may be more likely to have side effects from Periactin.. ...
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This eMedTV Web page explores the results of studies on Remicade and pregnancy. It explains why the FDA categorizes it as a pregnancy Category B medicine based on the results of these animal studies and offers suggestions for pregnant women.
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But it is not about senses anyway. The commonality between Taichi listening and aural listening is not in the sensing part or neural physiology, rather, it lies in the mechanical aspect of listening. Taichi is about interaction that is carried out with movement and so movement is central to what Taichi is about. If aural listening is relevant to Taichi listening it is the mechanical movement in the process of aural listening that is responsible for the correlation and is not known to the ancient. In our aural listening system the ears transform the vibration of the air into neuronal electrical pulses and our brain turns this signal into aural perception of sound. Conversely we may say that brain listens to the neural signal from the cochlea, cochlea listens to stapes, stapes listens to incus, incus to malleus, malleus to tympanic membrane and tympanic membrane to the movement of the air. Tympanic membrane listens to the movement of air by moving in synch with the air, malleus listens to tympanic ...
Ventral view into the right middle ear of a dog. The malleus (Manubrium mallei) adheres to the medial aspect of the tympanic membrane and pulls it towards the tympanic bulla. Note the Chorda tympani which crosses the tympanic membrane underneath the muscular process of the malleus ...
TY - JOUR. T1 - Epidemiological tracking and population assignment of the non-clonal bacterium, burkholderia pseudomallei. AU - Dale, Julia. AU - Price, Erin P.. AU - Hornstra, Heidie. AU - Busch, Joseph D.. AU - Mayo, Mark. AU - Godoy, Daniel. AU - Wuthiekanun, Vanaporn. AU - Baker, Anthony. AU - Foster, Jeffrey T. AU - Wagner, David M. AU - Tuanyok, Apichai. AU - Warner, Jeffrey. AU - Spratt, Brian G.. AU - Peacock, Sharon J.. AU - Currie, Bart J.. AU - Keim, Paul S. AU - Pearson, Talima R. PY - 2011/12. Y1 - 2011/12. N2 - Rapid assignment of bacterial pathogens into predefined populations is an important first step for epidemiological tracking. For clonal species, a single allele can theoretically define a population. For non-clonal species such as Burkholderia pseudomallei, however, shared allelic states between distantly related isolates make it more difficult to identify population defining characteristics. Two distinct B. pseudomallei populations have been previously identified using ...
Easton A, Haque https://www.ncbi.nlm.nih.gov/pubmed/?term=19829050%5Bpmid%5DA, Chu K, Lukaszewski R, Bancroft GJ. 2007. A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. J Infect Dis 195: 99-107. A Critical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei. ...
The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis. Melioidosis has the potential to pose a severe threat to public health and safety. In the United States, Bp is listed as a Tier-1 select agent by the Centers for Disease Control and Prevention (CDC), thus requiring high levels of regulation and biosafety level 3 (BSL3) facilities for experimental manipulation of live organisms. An avirulent ∆purM derivative of strain 1026b (Bp82) has proven to be a valuable tool for biosafe research as a select-agent excluded strain, but the high level of genetic diversity between Bp strains necessitates an expansion of the biosafe toolset. The ∆purM mutation was recapitulated in the Bp 576a strain, a serotype B background. An important difference between strains 1026b and 576a is the lipopolysaccharide (LPS), a major virulence factor and protective antigen. Polyclonal sera from 1026b-challenged non-human
A period of incubation, lasting from three to five days, generally follows the introduction of the virus into the system. This period, however, appears sometimes to be of much longer duration, especially where there has been no direct inoculation of the poison. The first symptoms are a general feeling of illness, accompanied with pains in the limbs and joints resembling those of acute rheumatism. If the disease has been introduced by means of an abraded surface, pain is felt at that point, and inflammatory swelling takes place there, and extends along the neighbouring lymphatics. An ulcer is formed at the point of inoculation which discharges an offensive ichor, and blebs appear in the inflamed skin, along with diffuse abscesses, as in phlegmonous erysipelas. Sometimes the disease stops short with these local manifestations, but more commonly goes on rapidly accompanied with symptoms of grave constitutional disturb-ance. Over the whole surface of the body there appear numerous red spots or ...
Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst quinolones and aminoglycosides have no reliable effect. As therapeutic options are limited, development of more effective forms of immunotherapy is vital to avoid a fatal outcome. In an earlier study, we reported on the B. pseudomallei serine MprA protease which is relatively stable over a wide pH and temperature range and digests physiological proteins. The present study was carried out to evaluate the immunogenicity and protective efficacy of the MprA as a potential vaccine candidate. In BALB/c mice immunized with recombinant MprA protease (smBpF4), a significantly high IgG titer was detectable. Isotyping studies revealed that the smBpF4-specific antibodies produced were predominantly IgG1, proposing that immunization with smBpF4 triggered a Th2 immune response. Mice were immunized with smBpF4 and subsequently challenged with B. pseudomallei via the intraperitoneal route. Whilst
Burkholderia pseudomallei is a human and animal pathogen in tropical regions, especially Southeast Asia and northern Australia. Currently little is known about the genetics and molecular biology of this organism. In this report, we describe the mutagenesis of B. pseudomallei with the transposon Tn5-OT182. B. pseudomallei 1026b transposon mutants were obtained at a frequency of 4.6 x 10(-4) per initial donor cell, and the transposon inserted randomly into the chromosome. We used Tn5-OT182 to identify the flagellin structural gene, fliC. We screened 3,500 transposon mutants and identified 28 motility mutants. Tn5-OT182 integrated into 19 unique genetic loci encoding proteins with homology to Escherichia coli and Salmonella typhimurium flagellar and chemotaxis proteins. Two mutants, MM35 and MM36, contained Tn5-OT182 integrations in fliC. We cloned and sequenced fliC and used it to complement MM35 and MM36 in trans. The fliC transcriptional start site and a sigmaF-like promoter were identified by ...
We evaluated the correlation of Burkholderia pseudomallei quantities in blood versus urine, sputum or pus. Correlations between bacterial counts in blood and other samples were not found. It is likely that an initial seeding event to extracellular organs is followed by independent growth of B. pseudomallei, and that bacteria in the urine were not passively filtered from the bloodstream.
Background: Although melioidosis in endemic regions is usually caused by a diverse range of Burkholderia pseudomallei strains, clonal outbreaks from contaminated potable water have been described. Furthermore B. pseudomallei is classified as a CDC Group B bioterrorism agent. Ribotyping, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) have been used to identify genetically related B. pseudomallei isolates, but they are time consuming and technically challenging for many laboratories ...
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Definition of farcy in US English - glanders in horses (or a similar disease in cattle) in which there is inflammation of the lymph vessels, causing nodules
Melioidosis is diagnosed by isolating Burkholderia pseudomallei from blood, urine, sputum, skin lesions, or abscesses; or by detecting an antibody response to the bacteria.
You will get two genes to analyze for horizontal gene transfer (HGT), from "Category A" and "Category B". Gene-Category-A: your first gene is an example where HGT is known to have occurred. Gene-Category-B: your second gene is an example where it is not yet known whether HGT has occurred.. Gene-Category-A collection (HGT is known to have occurredp; recipient means the organism that received the gene via HGT and donor means the organism that the gene came from.):. ...
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Citation. Tumapa, S., Holden, M. T., Vesaratchavest, M., Wuthiekanun, V., Limmathurotsakul, D., Chierakul, W., Feil, E. J., Currie, B. J., Day, N. P., Nierman, W. C., Peacock, S. J.. Burkholderia pseudomallei Genome Plasticity Associated With Genomic Island Variation. BMC Genomics. 2008 Apr 25; 9(1): 190.. PubMed Citation. Abstract. ABSTRACT: BACKGROUND: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence potential. The genome contains genomic island (GI) regions that encode a broad array of functions. Although there is some evidence for the variable distribution of genomic islands in B. pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival. RESULTS: Five islands from B. pseudomallei strain K96243 were chosen as representatives of ...
Cystic fibrosis (CF) is a genetic disorder characterized by progressive lung function decline. CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia pseudomallei, the causative agent of melioidosis. Here, we compared the genomes of B. pseudomallei isolates collected between similar to 4 and 55 months apart from seven chronically infected CF patients. Overall, the B. pseudomallei strains showed evolutionary patterns similar to those of other chronic infections, including emergence of antibiotic resistance, genome reduction, and deleterious mutations in genes involved in virulence, metabolism, environmental survival, and cell wall components. We documented the first reported B. pseudomallei hypermutators, which were likely caused by defective MutS. Further, our study identified both known and novel molecular mechanisms conferring resistance to three of the five clinically important antibiotics for melioidosis treatment. Our ...
TY - JOUR. T1 - Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil. AU - Rolim, D.B.. AU - Vilar, D.C.F.L.. AU - De Goes Cavalcanti, L.P.. AU - Freitas, C.L.B.N.. AU - Inglis, Tim. AU - Nobre Rodrigues, J.L.N.. AU - Nagao-Dias, A.T.. PY - 2011. Y1 - 2011. N2 - A seroepidemiological investigation was conducted among the population of two municipalities in Northeastern Brazil. Immunoglobulin M (IgM) and IgG antibodies to Burkholderia pseudomallei were positive in 51.27% (161 in 317 samples) and 58.49% (186), respectively. IgM titers were higher in children than in adults. On the contrary, IgG increased progressively with age. We observed a significant association between agricultural occupation and raised IgM titers (P ,0.005) and IgG titers (P ,0.001), and between construction workers and raised IgG titers (P = 0.005). Antibody IgG avidities did not correlate with age. The highest titers of antibodies (1/800) showed the highest antibody avidity ...
Abstract Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection endemic to many tropical regions. Lipopolysaccharide (LPS) is recognized as an important virulence factor used by B. pseudomallei. Isolates of B. pseudomallei have been shown to express one of four different types of LPS (typical LPS, atypical LPS types B and B2, and rough LPS) and in vitro studies have demonstrated that LPS types may impact disease severity. The association between LPS types and clinical manifestations, however, is still unknown, in part because an effective method for LPS type identification is not available. Thus, we developed antigen capture immunoassays capable of distinguishing between the LPS types. Mice were injected with B or B2 LPS for atypical LPS-specific monoclonal antibody (mAb) isolation; only two mAbs (3A2 and 5B4) were isolated from mice immunized with B2 LPS. Immunoblot analysis and surface plasmon resonance demonstrated that 3A2 and 5B4 are reactive with both B2 and B LPS
A hearing assistance system senses sound vibrations of an auditory element in the middle ear and provides a stimulus to an auditory sensory element. The vibrations are received through the tympanic membrane, and sensed at the tympanic membrane, malleus, incus, or other auditory element. A capacitive sensor is mechanically or magnetically coupled to a vibrating auditory element, such as the malleus, and time-varying capacitance values resulting from the vibrations are detected. One embodiment allows pivotable mechanical coupling of the capacitive sensor to at least one of the auditory element and a carrier secured within the middle ear. A resulting electrical output signal is provided to the output stimulator for assisting hearing.
Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, wit...
The reaction of the catalase-peroxidase of Burkholderia pseudomallei with peroxyacetic acid has been analyzed using stopped-flow spectrophotometry. Two well-defined species were observed, the first de
Following the high-profile laboratory incidents involving select agents and toxins that occurred at federally regulated laboratories, the National Science and Technology Council established a Fast Track Action Committee on the Select Agent Regulations(FTAC-SAR) under the Subcommittee on Biological Defense Research and Development of its Committee on Homeland and National Security. The FTAC and the White House Office of Science and Technology Policy convened two listening sessions and published a Request for Public Comment in the Federal Register to engage input into how the Select Agent Regulations (SAR) have impacted science, technology, and national security in the United States. Based on this input, the FTAC published the Fast Track Action Committee Report that offered recommendations for FSAP program improvement.. Recommendation #6 (Inventory Control Requirements) The FTAC recommends retaining requirements to maintain inventories of samples containing biological select agents and toxins, ...
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Category B - full version without watermark 720x576 (check terms and conditions at www.teledesign.de) The embed version with watermark is free of charge. Description: When a macrophage has eaten an invader, it presents an antigen fragment from the invader on its own surface, a process called antigen presentation. When the receptor of a helper T cell recognizes the antigen, the T cell is activated. Once activated, helper T cells start to divide and to produce proteins that activate B and T-killer cells. The killer T cell is specialized in attacking cells of the body infected by viruses and sometimes also by bacteria. The B lymphocyte cell searches for antigen matching its receptors. The second time an intruder tries to invade the body, B and T memory cells help the immune system to activate much faster.. ...
Loratadine disintegrating tablets (Claritin Reditab) may contain phenylalanine. Talk to your doctor before using Claritin Reditabs if you have phenylketonuria (PKU).. FDA pregnancy category B: Claritin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.. Follow your doctors instructions about any restrictions on food, beverages, or activity while you are using this medication.. ...
Loratadine disintegrating tablets (Claritin Reditab) may contain phenylalanine. Talk to your doctor before using Claritin Reditabs if you have phenylketonuria (PKU).. FDA pregnancy category B: Claritin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.. Follow your doctors instructions about any restrictions on food, beverages, or activity while you are using this medication.. ...
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Earlier this year I attended a presentation by Dr. Jay Sanguinetti, UNM, on using ultrasound stimulation of the brain to improve factors related to attention and clear thinking. His team published an article recently in Frontiers in Neurology describing their research.. ...
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Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is endemic in the tropics and a concern elsewhere as a biological warfare agent. Currently no human vaccine exists either in clinical trials or in a licensed form. Recently passively transferred monoclonal antibodies directed toward the expolysaccharide of B. pseudomallei have been shown to impart survival when administered prior to lethal challenge and active immunization using purified exopolysaccharide extends the mean time to death. Short peptides, termed mimotopes, mimicking native carbohydrate have been developed and used to induce protective responses against extracellular bacteria. Here the ability of mimotopes to generate a protective response against a pathogen that can invade host cells was investigated. Mimotopes immunoreactive to the passive protective monoclonals were developed and used to generate an antibody response against B. pseudomallei. Preliminary evaluation of the mimotopes in a murine ...
Abstract Melioidosis is a tropical disease of high mortality caused by the environmental bacterium, Burkholderia pseudomallei. We have collected clinical isolates from the highly endemic Northern Territory of Australia routinely since 1989, and animal and environmental B. pseudomallei isolates since 1991. Here we provide a complete record of all B. pseudomallei multilocus sequence types (STs) found in the Northern Territory to date, and distribution maps of the eight most common environmental STs. We observed surprisingly restricted geographic distributions of STs, which is contrary to previous reports suggesting widespread environmental dissemination of this bacterium. Our data suggest that B. pseudomallei from soil and water does not frequently disperse long distances following severe weather events or by migration of infected animals.
Background Burkholderia pseudomallei is the causative agent of melioidosis, a disease of significant morbidity and mortality in both human and animals in endemic areas. There is no vaccine towards the bacterium available in the market, and the efficacy of many of the bacteriums surface and secreted proteins are currently being evaluated as vaccine candidates. Methodology/Principal Findings With the availability of the B. pseudomallei whole genome sequence, we undertook to identify genes encoding the known immunogenic outer membrane protein A (OmpA). Twelve OmpA domains were identified and ORFs containing these domains were fully annotated. Of the 12 ORFs, two of these OmpAs, Omp3 and Omp7, were successfully cloned, expressed as soluble protein and purified. Both proteins were recognised by antibodies in melioidosis patients sera by Western blot analysis. Purified soluble fractions of Omp3 and Omp7 were assessed for their ability to protect BALB/c mice against B. pseudomallei infection. Mice were
Burkholderia pseudomallei is a Gram-negative bacterium that causes the serious human disease, melioidosis. There is no vaccine against melioidosis and it can be fatal if not treated with a specific antibiotic regimen, which typically includes the third-generation cephalosporin, ceftazidime (CAZ). There have been several resistance mechanisms described for B. pseudomallei, of which the best described are amino acid changes that alter substrate specificity in the highly conserved class A β-lactamase, PenA. In the current study, we sequenced penA from isolates sequentially derived from two melioidosis patients with wild-type (1.5 µg/mL) and, subsequently, resistant (16 or ≥256 µg/mL) CAZ phenotypes. We identified two single-nucleotide polymorphisms (SNPs) that directly increased CAZ hydrolysis. One SNP caused an amino acid substitution (C69Y) near the active site of PenA, whereas a second novel SNP was found within the penA promoter region. In both instances, the CAZ resistance phenotype ...
The Delhi government has decided to ban entry and exit of horses, mules, and donkeys in the city due to the spread of Glanders disease, Rural Development Minister Gopal Rai said here on Friday. Read full story of Delhi to ban entry, exit of horses, mules, donkeys due to disease at India News Section, newkerala.com
Many a medical student has prized his set of earbones, proof he was a careful dissector. The ear bones have a very special function There are the malleus, the incus, and the stapes. The way they are articulated takes the wide weak movements of the eardrum, and reduces their amplitude but increases the power to make the stapes (little stirrup) whose footplate fits into the oval window of inner ear, move powerfully enough to move the fluid waves to go up and around the helix, stimmulating nerves at different heights to produce sensation of different tones. A manifestation of the Almighty at his most magnificent ...
Have you heard about the new fossil mammal discovered in China? If you did, it was because of the three bones in your middle ear, known as the hammer (malleus), anvil (incus) and stirrup (stapes). They are the smallest bones in your skeleton -- each is about a quarter-inch long.
Date: April 21, 2017. Subject: Regulatory Interpretation regarding surrogate strains which can be used to validate inactivation procedures This is in response to your request, dated March 16, 2017 for a regulatory interpretation of the requirement which allows for the use of surrogate strains to validate inactivation procedures. The select agent regulations provide that surrogate strains that are known to possess equivalent properties with respect to inactivation can be used to validate an inactivation procedure. However, the select agent regulations also provide that if there are known strain-to-strain variations in the resistance of a select agent to an inactivation procedure, then an inactivation procedure validated on a lesser resistant strain must also be validated on the more resistant strains. See, for example, 42 C.F.R. § 73.3 (d)(4). For purposes of the requirement found in 42 C.F.R. §§ 73.3 and 4 (d)(4), 9 C.F.R. §§ 121.3 and 4 (d)(4), and 7 C.F.R. § 331.3 (d)(4), ...
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Bossé, J. T., Li, Y., Angen, O., Weinert, L. A., Chaudhuri, R. R., Holden, M. T., Williamson, S. M., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., Langford, P. R., on behalf of the BRaDP1T consortium & Holden, M. Jul 2014 In : Journal of Clinical Microbiology. p. 2380-2385 6 p.. Research output: Contribution to journal › Article ...
This eMedTV resource explores glyburide and pregnancy, explaining that it may not be safe to take the drug when pregnant. This page also explains why the FDA classifies glyburide as both a pregnancy Category B and pregnancy Category C medication.
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Burkholderia pseudomallei is the causative agent of melioidosis, a fatal human tropical disease. The non-specific DNA-binding protein DpsA plays a key role in protecting B. pseudomallei from oxidative stress mediated, for example, by organic hydroperoxides. The regulation of dpsA expression is poorly understood but one possibility is that it is regulated in a cell population density-dependent manner via N-acylhomoserine lactone (AHL)-dependent quorum sensing (QS) since a lux-box motif has been located within the dpsA promoter region. Using liquid chromatography and tandem mass spectrometry, it was first established that B. pseudomallei strain PP844 synthesizes AHLs. These were identified as N-octanoylhomoserine lactone (C8-HSL), N-(3-oxooctanoyl)homoserine lactone (3-oxo-C8-HSL), N-(3-hydroxyoctanoyl)-homoserine lactone (3-hydroxy-C8-HSL), N-decanoylhomoserine lactone (C10-HSL), N-(3-hydroxydecanoyl) homoserine lactone (3-hydroxy-C10-HSL) and N-(3-hydroxydodecanoyl)homoserine lactone (3-hydroxy-C12-HSL)
Burkholderia pseudomallei, the etiological agent of melioidosis, is a saprophytic bacterium existing endemically in the water and soil of SE Asia and Northern Australia. This organism has shown the ability to remain dormant in its host for decades. B. thailandensis is a closely related non-pathogenic near neighbor that is also found in these soils. It has been suggested that free-living amoeba could be natural reservoirs for these organisms. The interactions of Burkholderia species and Acanthamoeba castellanii, a species of free-living amoeba, were studied to better understand the natural ecology of these organisms and to determine the effects amoeba interactions might have on pathogenesis. In this study, the adherence and persistence of several B. pseudomallei clinical isolates were compared to that of B. thailandensis within both amoeba and a human monocyte cell line. Results showed that B. pseudomallei isolates can enter amoeba and survive therein at varying levels of efficiency. Some isolates were
No. 24102013-00012-EN. During the period 2001 to 2008, a total of 7,872 equine sera were tested at the Centre of Veterinary Institutes of Athens. Antibodies against seven infectious diseases of equids were determined: equine infectious anaemia (EIA), African horse sickness (AHS), equine viral arteritis (EVA), West Nile encephalitis (WNE), glanders, piroplasmosis and dourine. Tests for the four viral diseases found 4.5% seropositivity for EIA, 0% for AHS, 3.3% for EVA and 4% for WNE. All sera tested for glanders antibodies were negative. Tests for piroplasmosis detected antibodies against T. equi and B. caballi in 12.9% and 1.3% of the sera, respectively. No sample tested positive for dourine. The results of this epidemiological survey provide strong evidence that Greece is free from the diseases of AHS, glanders and dourine.. Keywords ...
Kynurenine formamidase (KynB) forms part of the kynurenine pathway which metabolises tryptophan to anthranilate. This metabolite can be used for downstream production of 2-alkyl-4-quinolone (AQ) signalling molecules that control virulence in Pseudomonas aeruginosa. Here we investigate the role of kynB in the production of AQs and virulence-associated phenotypes of Burkholderia pseudomallei K96243, the causative agent of melioidosis. Deletion of kynB resulted in reduced AQ production, increased biofilm formation, decreased swarming and increased tolerance to ciprofloxacin. Addition of exogenous anthranilic acid restored the biofilm phenotype, but not the persister phenotype. This study suggests the kynurenine pathway is a critical source of anthranilate and signalling molecules that may regulate B. pseudomallei virulence ...

Psychology of Medicine: GlandersPsychology of Medicine: Glanders

It is caused by infection with the bacterium Burkholderia mallei, usually by ingestion of contaminated food or water. Signs of ... Burkholderia mallei genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID ... B. mallei is able to infect humans, so is classed as a zoonotic agent. Transmission occurs by direct contact with infected ... Glanders (from Middle English glaundres or Old French glandres, both meaning glands) (Latin: malleus German: Rotz) (also known ...
more infohttp://monsterologist.blogspot.com/2014/12/glanders.html

Glanders : Oxford Textbook of Zoonoses - oiGlanders : Oxford Textbook of Zoonoses - oi

Glanders is caused by Burkholderia mallei, a Gram-negative, non-motile, facultative intracellular organism that is an obligate ... Glanders is caused by Burkholderia mallei, a Gram-negative, non-motile, facultative intracellular organism that is an obligate ... B. mallei is transmitted by direct contact with infected animals, or indirectly via communal food and water sources that have ... B. mallei is considered a potential biological weapon and is a Centers for Disease Control and Prevention category B select ...
more infohttp://oxfordindex.oup.com/view/10.1093/med/9780198570028.003.0029

Glanders | CDCGlanders | CDC

Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, ...
more infohttps://www.cdc.gov/glanders/

Burkholderia mallei - WikipediaBurkholderia mallei - Wikipedia

Burkholderia mallei is a Gram-negative, bipolar, aerobic bacterium, a Burkholderia-genus human and animal pathogen causing ... B. malleis genome also has a large amount of insertion sequences. B. mallei was first called "Bacillus mallei" and was in the ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ...
more infohttps://en.wikipedia.org/wiki/Burkholderia_mallei

sp=burkholderia mallei nctc 10229sp=burkholderia mallei nctc 10229

Organism: BURKHOLDERIA MALLEI NCTC 10229 18. BURM9_1_PE1013 (BURM9_1.PE1013). Organism: BURKHOLDERIA MALLEI NCTC 10229 19. ... Organism: BURKHOLDERIA MALLEI NCTC 10229 If you have problems or comments... Back to PBIL home page ... BURKHOLDERIA MALLEI NCTC 10229 8. BURM9_1_PE1004 (BURM9_1.PE1004). Keywords: hypothetical protein. Organism: BURKHOLDERIA ... Organism: BURKHOLDERIA MALLEI NCTC 10229 2. BURM9_1_PE10 RecName: Full=UvrABC system protein B; (BURM9_1.PE10). Keywords: ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-sp?query=Burkholderia%20mallei%20nctc%2010229&db=HOGENOM&ident=SCRATCH

Burkholderia mallei NCTC 10229 chromosome II, complete sequence - Nucleotide - NCBIBurkholderia mallei NCTC 10229 chromosome II, complete sequence - Nucleotide - NCBI

Burkholderia mallei NCTC 10229 chromosome II, complete sequence Burkholderia mallei NCTC 10229 chromosome II, complete sequence ... Burkholderia mallei NCTC 10229 chromosome II, complete sequence. NCBI Reference Sequence: NC_008835.1 ...
more infohttps://www.ncbi.nlm.nih.gov/nuccore/NC_008835

Burkholderia (Pseudomonas) mallei | MSDSonlineBurkholderia (Pseudomonas) mallei | MSDSonline

NAME: Burkholderia (Pseudomonas) mallei SYNONYM OR CROSS REFERENCE: Glanders, Malleomyces mallei, Farcy, Malleus; formerly ...
more infohttps://www.msdsonline.com/resources/sds-resources/free-safety-data-sheet-index/burkholderia-mallei/

argH - Argininosuccinate lyase - Burkholderia mallei (strain SAVP1) - argH gene & proteinargH - Argininosuccinate lyase - Burkholderia mallei (strain SAVP1) - argH gene & protein

sp,A1V5V1,ARLY_BURMS Argininosuccinate lyase OS=Burkholderia mallei (strain SAVP1) OX=320388 GN=argH PE=3 SV=1 ... Burkholderia mallei (strain SAVP1). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy% ... cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › ...
more infohttps://www.uniprot.org/uniprot/A1V5V1

KEGG PATHWAY: Carbon metabolism - Burkholderia mallei NCTC 10247KEGG PATHWAY: Carbon metabolism - Burkholderia mallei NCTC 10247

Carbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excluding a cofactor (CoA, CoM, THF, or THMPT) that is replaced by an asterisk. The map contains carbon utilization pathways of glycolysis (map00010), pentose phosphate pathway (map00030), and citrate cycle (map00020), and six known carbon fixation pathways (map00710 and map00720) as well as some pathways of methane metabolism (map00680). The six carbon fixation pathways are: (1) reductive pentose phosphate cycle (Calvin cycle) in plants and cyanobacteria that perform oxygenic photosynthesis, (2) reductive citrate cycle in photosynthetic green sulfur bacteria and some chemolithoautotrophs, (3) 3-hydroxypropionate bi-cycle in photosynthetic green nonsulfur bacteria, two variants of 4-hydroxybutyrate pathways in Crenarchaeota called (4) hydroxypropionate-hydroxybutyrate cycle and (5) ...
more infohttp://www.genome.jp/kegg-bin/show_pathway?bmn01200+BMA10247_1599

argH - Argininosuccinate lyase - Burkholderia mallei (strain ATCC 23344) - argH gene & proteinargH - Argininosuccinate lyase - Burkholderia mallei (strain ATCC 23344) - argH gene & protein

sp,Q62LD1,ARLY_BURMA Argininosuccinate lyase OS=Burkholderia mallei (strain ATCC 23344) OX=243160 GN=argH PE=3 SV=1 ... Burkholderia mallei (strain ATCC 23344). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_ ... cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › ...
more infohttps://www.uniprot.org/uniprot/Q62LD1

Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei - Volume 14, Number 7-July 2008 -...Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei - Volume 14, Number 7-July 2008 -...

Exposure to Burkholderia mallei. Glanders is a disease of equines caused by Burkholderia mallei, which appears to be a clone of ... Nierman WC, DeShazer D, Kim HS, Tettelin H, Nelson KE, Feldblyum T, Structural flexibility in the Burkholderia mallei genome. ... Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the ... Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei On This Page ...
more infohttp://www.cdc.gov/EID/content/14/7/e2.htm

Frontiers | Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei | MicrobiologyFrontiers | Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei | Microbiology

This review distils key findings from in silico, in vitro and in vivo studies on the ATs of B. pseudomallei and B. mallei. To ... This review distils key findings from in silico, in vitro and in vivo studies on the ATs of B. pseudomallei and B. mallei. To ... Several predicted Burkholderia ATs are recognized by human humoral and cell-mediated immunity, indicating that they are ... Several predicted Burkholderia ATs are recognized by human humoral and cell-mediated immunity, indicating that they are ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2011.00151/full

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus) - ONAGlanders (Farcy, Burkholderia mallei infection, equinia, malleus) - ONA

Bacillus mallei, Pfeifferella mallei, Loefflerella mallei, Malleomyces mallei, and Actinobacillus mallei. ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
more infohttps://www.oncologynurseadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587915/

Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-like Variation in the bimA Motility Gene,...Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-like Variation in the bimA Motility Gene,...

In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. ... Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation ... potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. ... Massey S, Johnston K, Mott TM, Judy BM, Kvitko BH, Schweizer HP, et al. In vivo bioluminescence imaging of Burkholderia mallei ...
more infohttps://wwwnc.cdc.gov/eid/article/23/5/15-1417_article

Table 2 - Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei - Volume 14, Number 7-July...Table 2 - Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei - Volume 14, Number 7-July...

Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei Sharon J. Peacock*. , Herbert P. ... Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei. ...
more infohttps://wwwnc.cdc.gov/eid/article/14/7/07-1501-t2

PULSED-FIELD GEL ELECTROPHORESIS AS A DISCRIMINATORY TYPING TECHNIQUE FOR THE BIOTHREAT AGENT BURKHOLDERIA MALLEI | The...PULSED-FIELD GEL ELECTROPHORESIS AS A DISCRIMINATORY TYPING TECHNIQUE FOR THE BIOTHREAT AGENT BURKHOLDERIA MALLEI | The...

... was used to type 21 laboratory strains of Burkholderia mallei. We demonstrated good resolution by PFGE together with clustering ... of some geographically related isolates, and confirmed previous observations that B. mallei is clonal as defined by MLST. ... Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol 41 : 2068-2079.. [Google Scholar] ... Structural flexibility in the Burkholderia mallei genome. Proc Natl Acad Sci U S A 101 : 14246-14251.. [Google Scholar] ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.2006.74.345

Evaluation of a Latex Agglutination Assay for the Identification of Burkholderia pseudomallei and Burkholderia mallei | The...Evaluation of a Latex Agglutination Assay for the Identification of Burkholderia pseudomallei and Burkholderia mallei | The...

... mallei, but is absent in closely related Burkholderia species. A total of 110 B. pseudomallei and B. mallei were tested, and 36 ... Burkholderia pseudomallei and Burkholderia mallei, respectively) are classified as Tier 1 select agents because of concerns ... Our laboratory has further evaluated a latex agglutination assay for its ability to identify B. pseudomallei and B. mallei ... The latex agglutination assay was positive for 109 of 110 (99.1% sensitivity) B. pseudomallei and B. mallei isolates tested. ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.14-0025

Burkholderia Mallei and Pseudomallei (Glanders and Melioidosis)Burkholderia Mallei and Pseudomallei (Glanders and Melioidosis)

Glanders is caused by infection with the bacterium Burkholderia mallei, and melioidosis is caused by Burkholderia pseudomallei. ... Currie B. Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and glanders. Chapter 218 in: Principles and Practice ... Currie B. Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and glanders. Chapter 218 in Principles and Practice ... Glanders is caused by infection with the bacterium Burkholderia mallei, and melioidosis is caused by Burkholderia pseudomallei ...
more infohttp://www.centerforhealthsecurity.org/our-work/publications/glanders-and-melioidosis-fact-sheet

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus)Glanders (Farcy, Burkholderia mallei infection, equinia, malleus)

Bacillus mallei, Pfeifferella mallei, Loefflerella mallei, Malleomyces mallei, and Actinobacillus mallei. ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
more infohttp://www.clinicalpainadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587919/

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus) - Cancer Therapy AdvisorGlanders (Farcy, Burkholderia mallei infection, equinia, malleus) - Cancer Therapy Advisor

Bacillus mallei, Pfeifferella mallei, Loefflerella mallei, Malleomyces mallei, and Actinobacillus mallei. ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
more infohttps://www.cancertherapyadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587913/

A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei. - Semantic ScholarA CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei. - Semantic Scholar

... was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was ... A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.. @article{Waag2006ACO, title={ ... A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.}, author={David M. Waag and ... was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was ...
more infohttps://www.semanticscholar.org/paper/A-CpG-oligonucleotide-can-protect-mice-from-a-low-Waag-McCluskie/748ae6b1908e17ed1b6a5f40b773163b2cc59937

BMA0137 protein (Burkholderia mallei) - STRING interaction networkBMA0137 protein (Burkholderia mallei) - STRING interaction network

Burkholderia mallei, Burkholderia mallei ATCC 23344, Burkholderia mallei ATCC23344, Burkholderia mallei str. ATCC 23344 ... Burkholderia mallei. NCBI taxonomy Id: 243160. Other names: B. mallei ATCC 23344, ...
more infohttps://string-db.org/network/243160.BMA0137

Burkholderia mallei (glanders) - LABOKLIN GMBH & CO.KG LABOR FÜR KLINISCHE DIAGNOSTIKBurkholderia mallei (glanders) - LABOKLIN GMBH & CO.KG LABOR FÜR KLINISCHE DIAGNOSTIK

Glanders is a disease of Equidae caused by Burkholderia mallei, which also has zoonotic potential: Apart from humans, wildcats ... You are here LABOKLIN / Produits / Maladies inféctieuses: agents pathogènes et détéctions danticorps / Bacteria / Burkholderia ...
more infohttps://laboklin.com/fr/produits/maladies-infectieuses-agents-pathogenes-et-detections-danticorps/bacteria/burkholderia-mallei-glanders/

Increased neurotropic threat from Burkholderia pseudomallei strains with a B. mallei-like variation in the bimA motility gene,...Increased neurotropic threat from Burkholderia pseudomallei strains with a B. mallei-like variation in the bimA motility gene,...

Increased neurotropic threat from Burkholderia pseudomallei strains with a B. mallei-like variation in the bimA motility gene, ... Increased neurotropic threat from Burkholderia pseudomallei strains with a B. mallei-like variation in the bimA motility gene, ... In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. ... Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation ...
more infohttps://researchonline.jcu.edu.au/50375/
  • The LAMP assay could detect as low as 1 pg of B. mallei genomic DNA and 5.5 × 10 3 CFU/ml of B. mallei in spiked human blood. (cdc.gov)
  • Because B. mallei is an obligate mammalian pathogen, it must infect a host mammal to live and to be transmitted from one host to another. (wikipedia.org)
  • B. mallei has a polysaccharide capsule which indicates its potential as a pathogen. (wikipedia.org)
  • Development of a real-time loop-mediated isothermal amplification assay for detection of Burkholderia mallei. (cdc.gov)
  • In present investigation, a set of six B. mallei-specific primers were designed and a simple, rapid, specific and sensitive real-time loop-mediated isothermal amplification (LAMP) assay was developed for detection of B. mallei. (cdc.gov)
  • Of the remaining eight predicted B. pseudomallei trimeric autotransporters, five of which are also present in B. mallei , two (BoaA and BoaB), have been implicated in bacterial adhesion to epithelial cells. (frontiersin.org)
  • The gene encoding this B. mallei protein, designated boaA , was expressed in Escherichia coli and shown to significantly increase adherence to human epithelial cell lines, specifically HEp2 (laryngeal cells) and A549 (type II pneumocytes), as well as to cultures of normal human bronchial epithelium (NHBE). (beds.ac.uk)