Infections with bacteria of the genus BURKHOLDERIA.
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.
A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.
A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.
A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.
A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.
A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.

Comparison of isolation media for recovery of Burkholderia cepacia complex from respiratory secretions of patients with cystic fibrosis. (1/346)

Burkholderia cepacia selective agar (BCSA) has previously been devised for isolation of B. cepacia from respiratory secretions of patients with cystic fibrosis and tested under research laboratory conditions. Here we describe a study in which BCSA, oxidation-fermentation polymyxin bacitracin lactose agar (OFPBL), and Pseudomonas cepacia agar (PCA) were compared in routine culture procedures for the ability to grow B. cepacia and inhibit other organisms. Three hundred twenty-eight specimens from 209 patients at two pediatric centers and 328 specimens from 109 adults were tested. Plates were inoculated, incubated, and read for quality and quantity of growth at 24, 48, and 72 h. Five (1.5%) specimens from 4 (1.9%) children and 75 (22.9%) specimens from 16 (14.7%) adults grew B. cepacia complex. At 24, 48, and 72 h, BCSA achieved 43, 93, and 100% detection, respectively; OFPBL achieved 26, 84, and 96%, respectively; and PCA achieved 33, 74, and 84% detection, respectively. Quality was assessed as pinpoint or good growth. At 24 h, most cultures growing B. cepacia complex had pinpoint colonies. By 48 and 72 h, 48 and 69% of B. cepacia complex cultures, respectively, had good growth on BCSA, while on OFPBL 19 and 30%, respectively, had good growth and on PCA 11 and 18%, respectively, had good growth. BCSA was superior to OFPBL and PCA in suppressing organisms other than B. cepacia complex; 40 non-B. cepacia complex organisms were isolated from BCSA, 263 were isolated from OFPBL, and 116 were isolated from PCA. We conclude that BCSA is superior to OFPBL and PCA in its ability to support the growth of B. cepacia complex and to suppress other respiratory organisms.  (+info)

Structural elucidation of a novel exopolysaccharide produced by a mucoid clinical isolate of Burkholderia cepacia. Characterization of a trisubstituted glucuronic acid residue in a heptasaccharide repeating unit. (2/346)

The structure of the exopolysaccharide (EPS) produced by a clinical isolate of Burkholderia cepacia isolated from a patient with fibrocystic lung disease has been investigated. By means of methylation analyses, carboxyl reduction, partial depolymerization by fuming HCl and chemical degradations such as Smith degradation, lithiumethylenediamine degradation and beta-elimination, supported by GC/MS and NMR spectroscopic analyses, the repeat unit of the EPS has been identified and was shown to correspond to the acidic branched heptasaccharide with the following structure: [formula: see text]. This partially acetylated acidic polymer, distinguished by the presence of the less usual D-isomer of rhamnose and of a trisubstituted glucuronic acid residue, could represent the main EPS produced by this bacterial species.  (+info)

An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. (3/346)

Burkholderia cepacia is an important pathogen in cystic fibrosis (CF) and an infrequent cause of nosocomial infection in non-CF patients. This report describes a large hospital outbreak that appeared to involve both patient groups, a previously unrecognized phenomenon. Ribotype restriction fragment length polymorphism (RFLP) profiles and pulsed-field gel electrophoresis-resolved macrochromosomal RFLPs were analyzed, a ribotype-based phylogenic tree was constructed, and case-control and cohort studies were performed. A single dominant clone was found in both CF and non-CF groups. Phylogenic analysis suggests that it has evolved independently and that such highly transmissible strains can emerge rapidly and randomly. Acquisition risk in the CF patients was linked to hospitalization (odds ratio=5.47, P=.0158, confidence interval=1. 28-26.86) and was associated with significantly increased mortality rates. Infection control policies must now consider this threat of transmission between non-CF and CF patients.  (+info)

Identification of Burkholderia spp. in the clinical microbiology laboratory: comparison of conventional and molecular methods. (4/346)

Cystic fibrosis (CF) predisposes patients to bacterial colonization and infection of the lower airways. Several species belonging to the genus Burkholderia are potential CF-related pathogens, but microbiological identification may be complicated. This situation is not in the least due to the poorly defined taxonomic status of these bacteria, and further validation of the available diagnostic assays is required. A total of 114 geographically diverse bacterial isolates, previously identified in reference laboratories as Burkholderia cepacia (n = 51), B. gladioli (n = 14), Ralstonia pickettii (n = 6), B. multivorans (n = 2), Stenotrophomonas maltophilia (n = 3), and Pseudomonas aeruginosa (n = 11), were collected from environmental, clinical, and reference sources. In addition, 27 clinical isolates putatively identified as Burkholderia spp. were recovered from the sputum of Dutch CF patients. All isolates were used to evaluate the accuracy of two selective growth media, four systems for biochemical identification (API 20NE, Vitek GNI, Vitek NFC, and MicroScan), and three different PCR-based assays. The PCR assays amplify different parts of the ribosomal DNA operon, either alone or in combination with cleavage by various restriction enzymes (PCR-restriction fragment length polymorphism [RFLP] analysis). The best system for the biochemical identification of B. cepacia appeared to be the API 20NE test. None of the biochemical assays successfully grouped the B. gladioli strains. The PCR-RFLP method appeared to be the optimal method for accurate nucleic acid-mediated identification of the different Burkholderia spp. With this method, B. gladioli was also reliably classified in a separate group. For the laboratory diagnosis of B. cepacia, we recommend parallel cultures on blood agar medium and selective agar plates. Further identification of colonies with a Burkholderia phenotype should be performed with the API 20NE test. For final confirmation of species identities, PCR amplification of the small-subunit rRNA gene followed by RFLP analysis with various enzymes is recommended.  (+info)

Differentiation of Burkholderia species by PCR-restriction fragment length polymorphism analysis of the 16S rRNA gene and application to cystic fibrosis isolates. (5/346)

Burkholderia cepacia, which is an important pathogen in cystic fibrosis (CF) owing to the potential severity of the infections and the high transmissibility of some clones, has been recently shown to be a complex of five genomic groups, i.e., genomovars I, II (B. multivorans), III, and IV and B. vietnamiensis. B. gladioli is also involved, though rarely, in CF. Since standard laboratory procedures fail to provide an accurate identification of these organisms, we assessed the ability of restriction fragment length polymorphism (RFLP) analysis of amplified 16S ribosomal DNA (rDNA), with the combination of the patterns obtained with six endonucleases, to differentiate Burkholderia species. This method was applied to 16 type and reference strains of the genus Burkholderia and to 51 presumed B. cepacia clinical isolates, each representative of one clone previously determined by PCR ribotyping. The 12 Burkholderia type strains tested were differentiated, including B. cepacia, B. multivorans, B. vietnamiensis, and B. gladioli, but neither the genomovar I and III reference strains nor the genomovar IV reference strain and B. pyrrociniaT were distinguishable. CF clinical isolates were mainly distributed in RFLP group 2 (which includes B. multivoransT) and RFLP group 1 (which includes B. cepacia genomovar I and III reference strains, as well as nosocomial clinical isolates). Two of the five highly transmissible clones in French CF centers belonged to RFLP group 2, and three belonged to RFLP group 1. The remaining isolates either clustered with other Burkholderia species (B. cepacia genomovar IV or B. pyrrocinia, B. vietnamiensis, and B. gladioli) or harbored unique combinations of patterns. Thus, if further validated by hybridization studies, PCR-RFLP of 16S rDNA could be an interesting identification tool and contribute to a better evaluation of the respective clinical risks associated with each Burkholderia species or genomovar in patients with CF.  (+info)

Analysis of fliC variation among clinical isolates of Burkholderia cepacia. (6/346)

PCR and restriction fragment length polymorphism (RFLP) typing of flagellin genes (fliC) from 57 clinical isolates of Burkholderia cepacia indicated that only type 11 flagellins were present. Twenty-two isolates previously identified as the epidemic UK cystic fibrosis strain were indistinguishable by this method, as were 11 isolates from a pseudo-outbreak in Senegal. Other clinical isolates, including 19 from disparate sources in Malaysia, were separated into nine fliC RFLP groups, exhibiting a large degree of divergence. When isolates were indistinguishable by fliC genotyping, their similarity was confirmed by whole genome macro-restriction analysis with pulsed-field gel electrophoresis following XbaI digestion. The variation in fliC sequences of B. cepacia was far greater than that with B. pseudomallei, supporting the view that 'B. cepacia', as currently defined, may comprise several different genomic species.  (+info)

A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen. (7/346)

Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon knockout (GKO) BALB/c mice to facilitate dissection of components of pathogenicity and host defense. Both WT and GKO mice were susceptible to chronic splenic infection with B. cepacia, but not with Pseudomonas aeruginosa. B. cepacia strains from patients with CGD persisted longer than those from CF patients. C57BL/6 mice were the most susceptible murine strain; bacteria persisted in the spleen for 2 months. DBA/2, BALB/c, and A/J strains of mice were relatively resistant to infection. Certain strains of B. cepacia complex can persist in the murine spleen after systemic infection; this may provide clues to its virulence in compromised hosts, such as those with CGD and CF.  (+info)

Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebae. (8/346)

Members of the taxonomically diverse Burkholderia cepacia complex have become a major health risk for patients with cystic fibrosis (CF). Although patient-to-patient transmission of B. cepacia strains has been well-documented, very little is known about possible vehicles of transmission and reservoirs for these micro-organisms. In this work, it is shown that strains of the B. cepacia complex can survive within different isolates of the genus Acanthamoeba. Trophozoites containing bacteria developed profuse cytoplasmic vacuolization. Vacuolization was not detected in trophozoites infected with live Escherichia coli or heat-killed B. cepacia, or by incubation of trophozoites with filter-sterilized culture supernatants, indicating that metabolically active intracellular bacteria are required for the formation of vacuoles. Experiments with two different B. cepacia strains and two different Acanthamoeba isolates revealed that bacteria display a low level of intracellular replication approximately 72-96 h following infection. In contrast, extracellular bacteria multiplied efficiently on by-products released by amoebae. The findings suggest that amoebae may be a reservoir for B. cepacia and possibly a vehicle for transmission of this opportunistic pathogen among CF patients.  (+info)

Burkholderia infections are caused by bacteria belonging to the Burkholderia genus, which includes several species that can cause various types of infection in humans. The most well-known and medically significant species include Burkholderia cepacia complex (Bcc), Burkholderia pseudomallei, and Burkholderia mallei.

1. Burkholderia cepacia Complex (Bcc): These are a group of closely related bacteria that can be found in various environments such as soil, water, and plants. They can cause respiratory infections, particularly in people with weakened immune systems or chronic lung diseases like cystic fibrosis. Bcc infections can be difficult to treat due to their resistance to many antibiotics.

2. Burkholderia pseudomallei: This species is the causative agent of melioidosis, a potentially severe and life-threatening infection endemic in tropical and subtropical regions, particularly in Southeast Asia and northern Australia. The bacteria can be found in contaminated water and soil, and people can get infected through direct contact with contaminated sources, ingestion, or inhalation of the bacteria. Melioidosis symptoms may vary widely, from mild flu-like illness to severe pneumonia, abscesses, and sepsis.

3. Burkholderia mallei: This species is responsible for glanders, a rare but serious disease primarily affecting horses, donkeys, and mules. Human infections are usually associated with occupational exposure to infected animals or their secretions. Glanders can cause severe symptoms such as fever, pneumonia, sepsis, and skin ulcers.

Treatment of Burkholderia infections typically involves the use of specific antibiotics, often in combination therapy, depending on the species and severity of infection. In some cases, surgical intervention may be necessary to drain abscesses or remove infected tissues. Preventive measures include avoiding contact with contaminated sources, practicing good hygiene, and using appropriate personal protective equipment when handling animals or working in high-risk environments.

Burkholderia is a genus of gram-negative, rod-shaped bacteria that are widely distributed in the environment, including soil, water, and associated with plants. Some species of Burkholderia are opportunistic pathogens, meaning they can cause infection in individuals with weakened immune systems or underlying medical conditions.

One of the most well-known species of Burkholderia is B. cepacia, which can cause respiratory infections in people with cystic fibrosis and chronic granulomatous disease. Other notable species include B. pseudomallei, the causative agent of melioidosis, a potentially serious infection that primarily affects the respiratory system; and B. mallei, which causes glanders, a rare but severe disease that can affect humans and animals.

Burkholderia species are known for their resistance to many antibiotics, making them difficult to treat in some cases. Proper identification of the specific Burkholderia species involved in an infection is important for determining the most appropriate treatment approach.

'Burkholderia pseudomallei' is a Gram-negative, aerobic, motile, rod-shaped bacterium that is the causative agent of melioidosis. It is found in soil and water in tropical and subtropical regions, particularly in Southeast Asia and northern Australia. The bacterium can infect humans and animals through inhalation, ingestion, or direct contact with contaminated soil or water. Melioidosis can cause a wide range of symptoms, including pneumonia, sepsis, and abscesses in various organs. It is a serious and potentially fatal disease, especially in people with underlying medical conditions such as diabetes, kidney disease, or compromised immune systems. Proper diagnosis and treatment with appropriate antibiotics are essential for managing melioidosis.

Burkholderia cepacia is a gram-negative, motile bacillus that is commonly found in the environment, particularly in water and soil. It is a conditional pathogen, meaning it can cause infection in individuals with weakened immune systems or underlying lung conditions such as cystic fibrosis.

Infections caused by B. cepacia can be difficult to treat due to its resistance to many antibiotics. The bacteria can colonize the lungs and cause a chronic respiratory infection that can lead to decline in lung function, increased frequency of exacerbations, and even death in some cases. It is also associated with outbreaks in healthcare settings, particularly in patients receiving respiratory therapy or using contaminated medical equipment.

It's important to note that B. cepacia is not typically considered a community-acquired pathogen and is not commonly associated with typical pneumonia or other respiratory infections in healthy individuals.

The Burkholderia cepacia complex (Bcc) is a group of closely related bacterial species that are gram-negative, motile, and aerobic. These bacteria are commonly found in various environments such as soil, water, and vegetation. The Bcc organisms are known to be opportunistic pathogens, meaning they primarily cause infections in individuals with compromised immune systems or underlying lung conditions, such as cystic fibrosis (CF) patients.

Bcc infections can lead to a range of clinical manifestations, including pneumonia, bacteremia, and chronic lung colonization. The bacteria are particularly notorious for their high level of antibiotic resistance and their ability to form biofilms, making them difficult to eradicate from the lungs of CF patients. Accurate identification of Bcc species is essential for appropriate treatment and infection control measures.

Burkholderia cenocepacia is a species of gram-negative, motile bacteria that belongs to the family Burkholderiaceae. These bacteria are commonly found in various environments such as soil, water, and plant roots. They are known to form biofilms and can survive under a wide range of conditions, making them difficult to eradicate.

B. cenocepacia is an opportunistic pathogen that can cause serious respiratory infections in individuals with weakened immune systems, particularly those with cystic fibrosis (CF). In CF patients, B. cenocepacia infections can lead to a rapid decline in lung function and are associated with high mortality rates. The bacteria can also cause other types of infections such as bacteremia, wound infections, and urinary tract infections.

B. cenocepacia is resistant to many antibiotics, which makes treatment challenging. Infection control measures, such as contact isolation and rigorous environmental cleaning, are crucial in preventing the spread of B. cenocepacia in healthcare settings.

Melioidosis is a bacterial infection caused by the soil-dwelling gram-negative bacillus, Burkholderia pseudomallei. The disease primarily occurs in tropical areas such as Southeast Asia and northern Australia. It can present with a wide range of clinical manifestations including acute septicemia, pneumonia, and chronic suppurative infection. Risk factors for melioidosis include diabetes mellitus, renal disease, alcoholism, and lung disease. The diagnosis is confirmed by culturing B. pseudomallei from clinical specimens such as blood, sputum, or pus. Treatment typically involves a prolonged course of antibiotics, including intravenous ceftazidime followed by oral trimethoprim-sulfamethoxazole.

'Burkholderia gladioli' is a gram-negative, rod-shaped bacterium that belongs to the Burkholderia cepacia complex (Bcc). This complex includes several closely related species that can cause respiratory infections, particularly in people with weakened immune systems or chronic lung diseases such as cystic fibrosis.

'Burkholderia gladioli' is commonly found in the environment, including soil and water. It has been isolated from a variety of plants, including onions, gladiolus, and other flowers. While it can cause serious infections in humans, it is also being studied for its potential use in bioremediation and as a source of novel antibiotics.

Infections caused by 'Burkholderia gladioli' can be difficult to treat due to the bacterium's resistance to many commonly used antibiotics. Treatment typically involves the use of multiple antibiotics and close monitoring of the patient's response to therapy.

Glanders is a rare and serious disease caused by the bacterium Burkholderia mallei. It primarily affects horses, donkeys, and mules, but can also infect humans who come into contact with infected animals or contaminated materials. The disease is characterized by the formation of multiple abscesses in various organs, particularly the lungs, liver, spleen, and skin. In humans, glanders can cause fever, cough, chest pain, muscle aches, and pustules on the skin. It is a highly infectious disease and can be fatal if not treated promptly with appropriate antibiotics. Historically, it has been a concern in military settings due to its potential use as a biological weapon.

... or splenous infections. B. mallei infection has a fatality rate of 95% if left untreated, and a 50% fatality rate in ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ... Bondi SK, Goldberg JB (2008). "Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei". Expert ...
It is caused by infection with the bacterium Burkholderia mallei. Glanders is endemic in Africa, Asia, the Middle East, and ... Glanders is caused by infection with the Burkholderia mallei, usually by ingestion of contaminated feed or water. B. mallei is ... No vaccine is licensed for use in the U.S. Infection with these bacteria results in nonspecific symptoms and can be either ... Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is ...
... infection in humans is called melioidosis or Whitmore's disease. It is spread though direct contact ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450. (Articles with short description, ... October 2005). "Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for ... 2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ...
... is sometimes used to model B. pseudomallei infection in mice because of similarities in the immune ... Brett PJ, DeShazer D, Woods DE (1998). "Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species". Int J ... "Arabinose-positive Burkholderia pseudomallei infection in humans: case report". Clin Infect Dis. 28 (4): 927-28. doi:10.1086/ ... "Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection". Microb Pathog. 48 (1): 9- ...
In lung transplant patients, infection can be fatal as patients have developed bacteremia and sterile wound infections as a ... PubMed article on PCR identification of Burkholderia EMedicine overview of Burkholderia Type strain of Burkholderia gladioli at ... Burkholderia gladioli is closely related to, and often mistaken for, a member of the Burkholderia cepacia complex. This ... Burkholderia gladioli can be distinguished from the other Burkholderia because it is oxidase negative B. gladioli is indole ...
"Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence". ... Burkholderia cepacia complex in the NCBI Taxonomy Browser Type strain of Burkholderia cepacia complex at BacDive, the Bacterial ... Burkholderia cepacia is also found in marine environments (marine sponges) and some strains of Burkholderia cepacia can ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ...
"Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental ...
... biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic ... In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that few animals can ... The flushing action of tears and saliva helps prevent infection of the eyes and mouth. Inflammation is one of the first ... When host cells die, either by apoptosis or by cell injury due to an infection, phagocytic cells are responsible for their ...
... opportunistic infection due to Burkholderia cepacia complex can occur, especially through transmission from patient to patient ... Antibiotics by mouth such as ciprofloxacin or azithromycin are given to help prevent infection or to control ongoing infection ... This typically begins as a prolonged respiratory infection that continues until treated with antibiotics. Chronic infection of ... which makes infection even more difficult to eradicate. The natural history of CF lung infections and airway remodeling is ...
The recalled products said to contain Enterobacter gergoviae or Burkholderia cepecia, which may cause infections if applied to ...
Low JG, Quek AM, Sin YK, Ang BS (January 2005). "Mycotic aneurysm due to Burkholderia pseudomallei infection: case reports and ... Burkholderia thailandensis, Burkholderia mallei and Burkholderia cepacia complex". Journal of Microbiological Methods. 90 (3): ... Re-infection is due to a new strain of B. pseudomallei bacteria. Meanwhile, relapse is due to failure to clear infections after ... December 2012). "Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, ...
... infection mechanisms of Burkholderia pseudomallei and melioidosis. Peacock has published around 150 papers on these topics. ... In the same year she took up a secondment as Director of the National Infection Service, a department of Public Health England ... PHE) which operates laboratories working on bacterial infections and antibiotic resistance. By 2020 Peacock was seconded to the ... on genomics highlights the potential for pathogen genomics in patient diagnosis and infection control". On Medicine. BioMed ...
Such biofilms are present in many successful infections, such as the chronic Pseudomonas aeruginosa and Burkholderia ... This may give rise to a window of opportunity for infection and reactivation of latent virus infections, but the evidence is ... This is "adaptive" because it occurs during the lifetime of an individual as an adaptation to infection with that pathogen and ... Thus the immune response to infection may result in changes to the sleep cycle, including an increase in slow-wave sleep ...
Unlike Burkholderia species, Paraburkholderia members are not commonly associated with human infection. Paraburkholderia ... Additionally, the CSIs that were found to be shared by Burkholderia species are absent in Paraburkholderia, providing evidence ... Sawana A, Adeolu M, Gupta RS (2014). "Molecular signatures and phylogenomic analysis of the genus Burkholderia: proposal for ... which is what prompted their distinction as a genus independent from Burkholderia species, in combination with the finding of ...
Chua KL, Chan YY, Gan YH (April 2003). "Flagella are virulence determinants of Burkholderia pseudomallei". Infection and ... The worm's ability to recognise a beneficial strain, as well as preferential host-specific infection by bacteria have been both ... Infection and Immunity. 72 (6): 3237-44. doi:10.1128/IAI.72.6.3237-3244.2004. PMC 415653. PMID 15155625. Jones ML (July 1981 ... but are acquired from the environment through the skin in a process akin to an infection. The digestive tract transiently ...
Antibiotics used to treat Burkholderia pseudomallei infection (melioidosis), for example β-lactams, fluoroquinolones and ... As an example of this, during urinary tract infection, filamentous structures of uropathogenic E. coli (UPEC) start to develop ... Kang Chen; Guang Wen Sun; Kim Lee Chua; Yunn-Hwen Gan (March 2005). "Modified Virulence of Antibiotic-Induced Burkholderia ... "Filamentation by Escherichia coli subverts innate defenses during urinary tract infection". Proceedings of the National Academy ...
Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with ... Infective endocarditis: An infection of the endocardium caused by enterococcus; used when the organism is not sensitive to ... Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell ... Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, Mycobacterium ...
"Identification of a siderophore receptor required for ferric ornibactin uptake in Burkholderia cepacia". Infection and Immunity ... "Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia (formerly ... Coenye T, Vandamme P, Govan JR, LiPuma JJ (October 2001). "Taxonomy and identification of the Burkholderia cepacia complex". ... LiPuma JJ (September 1998). "Burkholderia cepacia. Management issues and new insights". Clinics in Chest Medicine. 19 (3): 473- ...
... burkholderia infections MeSH C01.252.400.170.400 - glanders MeSH C01.252.400.170.531 - melioidosis MeSH C01.252.400.177 - ... bacteroides infections MeSH C01.252.400.126 - bartonellaceae infections MeSH C01.252.400.126.100 - bartonella infections MeSH ... moraxellaceae infections MeSH C01.252.400.560.022 - acinetobacter infections MeSH C01.252.400.610 - mycoplasmatales infections ... salmonella infections, animal MeSH C01.252.400.310.821.873 - typhoid fever MeSH C01.252.400.310.850 - serratia infections MeSH ...
... and Burkholderia cepacia, an important pathogen of pulmonary infections in people with cystic fibrosis (CF). Burkholderia ... Burkholderia alpina Burkholderia ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia ... Burkholderia dolosa Burkholderia gladioli Burkholderia glumae Burkholderia humptydooensis Burkholderia lata Burkholderia latens ... Burkholderia mallei Burkholderia metallica Burkholderia multivorans Burkholderia oklahomensis Burkholderia plantarii ...
Burkholderia pseudomallei infection) DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk *1602:DQA1* ... "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890-5 ... 0102:DQB1*0502 haplotype: graves disease, cervical cancer (human papilloma virus infection), scleroderma *1602:DQA1*05:DQB1* ...
... à une infection à Burkholderia cepacia complex chez un nourrisson révélant une granulomatose septique et une intégration ... Primary infections in adults are rare since most occurrences are in children. When the infection does occur for the first time ... Once inside, two outcomes have been described: active and inactive infections. Active infections involve the linear dsDNA ... Lymphohistiocytic activation syndrome and Burkholderia cepacia complex infection in a child revealing chronic granulomatous ...
Re-infection is a recurrence of symptoms due to an infection with a new strain of Burkholderia pseudomallei following the ... This occurs when the infection (unless a new infection) has persisted in the blood at undetectable levels and then becomes ... In melioidosis, a recurrent infection can be due to re-infection and relapse. ... Recurrent melioidosis can result either from relapse due to failure to clear an infection or from reinfection with a new B. ...
In cystic fibrosis infections, it is common for only one of the known nine genomovars to induce an infection. Overall, in ... Burkholderia cenocepacia is one of over twenty bacteria in the Burkholderia cepacia complex (Bcc), and among these species, it ... Within the Burkholderia genus, the Burkholderia cepacia complex contains over 20 related species that cause opportunistic ... sRNAs identified in Burkholderia cenocepacia KC-0 were upregulated under iron depletion and oxidative stress.Burkholderia ...
Fresh-water bacterial infections include Aeromonas hydrophila, Burkholderia pseudomallei causing melioidosis, leptospira ... but often fatal infection called necrotizing fasciitis.[citation needed] Other salt-water Mycobacterium infections include the ... These infections are exacerbated with a compromised immune system or an aging population. The most common bacterial skin ... A worker can reduce the risk of flood-associated skin infections by avoiding the water if an open wound is present, or at ...
"Burkholderia contaminans: Unusual cause of biliary sepsis". Journal of Infection and Chemotherapy. 19 (5): 969-71. doi:10.1007/ ... Burkholderia contaminans is a gram-negative, bacterium from the genus of Burkholderia and the family of Burkholderiaceae and ... Burkholderia acidipaludis can cause biliary sepsis. "Genus Burkholderia". List of Prokaryotic Names with Standing in ... Type strain of Burkholderia contaminans at BacDive - the Bacterial Diversity Metadatabase v t e (Articles with short ...
The cause is usually a bacterial infection, but rarely can be a fungal infection. It may occur by spread from the blood or from ... Weinstein, Lenny; Knowlton, Christin A.; Smith, Miriam A. (2007-12-16). "Cervical osteomyelitis caused by Burkholderia cepacia ... Mixed infections are the rule rather than the exception. Systemic mycotic infections may also cause osteomyelitis. The two most ... Many infections are caused by Staphylococcus aureus, a member of the normal flora found on the skin and mucous membranes. In ...
During infection, some bacteria (e.g., Burkholderia pseudomallei) therefore produce superoxide dismutase to protect themselves ... August 2011). "Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei". ...
... after a product sample tested positive for Burkholderia pseudomallei, a deadly bacterial infection resulting in 2 deaths. USA: ...
In 2002, Peck experienced visual hallucinations and delusions caused by a bacterial brain infection. The bacteria, Burkholderia ...
Multistate Outbreak of Burkholderia cepacia Infections Associated with Contaminated Ultrasound Gel ... infections in healthcare facilities. Patients have developed Bcc infections, including bloodstream infections, after likely ... Types of Infectionsplus icon *Central Line-associated Bloodstream Infectionsplus icon *Resources for Patients & Providers ... As of August 18, 2021, CDC is aware of at least 59 patients in 6 states with Burkholderia stabilis infection with a bacterial ...
... J Pediatr. 2002 ... Study design: A case-control study was conducted with active surveillance for B cepacia complex colonization/infection among ... Objectives: To determine risk factors for acquiring Burkholderia cepacia complex among patients with cystic fibrosis (CF). ...
Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Burkholderia mallei. Carbohydr Res. 2013;381:6-11.. *Norris MH, Schweizer HP, Tuanyok A. Structural diversity of Burkholderia ...
Burkholderia are opportunistic pathogens. Here we describe a case of Burkholderia multivorans urinary tract infection in a ... Burkholderia, Urinary tract infection. in IDCases. volume. 17. article number. e00553. publisher. Elsevier. external ... Febrile urinary tract infection in an immunocompetent male caused by Burkholderia multivorans- evidence of transmission in a ... Here we describe a case of Burkholderia multivorans urinary tract infection in a previously healthy man. The bacterium was ...
The rapid production of IFN-gamma within the first day of infection determines whether the infection proceeds to an acute ... Intraperitoneal infection of TO mice at doses of ,10(6) CFU resulted in acute septic shock and death within 2 days. In contrast ... Resistance to acute infection with B. pseudomallei was absolutely dependent upon the production of gamma interferon (IFN-gamma ... We describe here a murine model of either acute or chronic infection with B. pseudomallei in Taylor Outbred (TO) mice which ...
Source implicated in fatal case in Georgia : multistate outbreak of non-travel associated Burkholderia pseudomallei Infections ... multistate outbreak of non-travel associated Burkholderia pseudomallei Infections (melioidosis) in four patients: Georgia, ... multistate outbreak of non-travel associated Burkholderia pseudomallei Infections (melioidosis) in four patients: Georgia, ... multistate outbreak of non-travel associated Burkholderia pseudomallei Infections (melioidosis) in four patients: Georgia, ...
Burkholderia cepacia is an aerobic gram-negative bacillus found in various aquatic environments. B cepacia is an organism of ... Skin and soft-tissue infections, surgical-wound infections, and genitourinary tract infections with B cepacia have been ... Pacemaker generator pocket infection due to Burkholderia cepacia. J Hosp Infect. 2007 Dec. 67(4):392-3. [QxMD MEDLINE Link]. ... Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis. J Microbiol. 2007 Jun. 45(3):275-9 ...
Key points • 139 sRNAs expressed by B. cenocepacia during C. elegans infection were identified • The sRNA RIT11b affects B. ... and chronic infections in other organisms. The in vitro direct interaction of RIT11b with the dusA and pyrC messengers was ... the nematode Caenorhabditis elegans was used as an infection model by the epidemic CF strain B. cenocepacia J2315. A total of ... elegans infection conditions, was shown to directly affect B. cenocepacia virulence, biofilm formation, and swimming motility. ...
Burkholderia cepacia Complex Infection in Italian Patients with Cystic Fibrosis.pdf accesso aperto ... The prevalence, epidemiology, and genomovar status of Burkholderia cepacia complex strains recovered from Italian cystic ... The prevalence, epidemiology, and genomovar status of Burkholderia cepacia complex strains recovered from Italian cystic ... there was a high incidence of infection caused by a single epidemic clone possessing the cbLA gene and belonging to B. cepacia ...
Burkholderia Infections Market Size is estimated to reach $430 million by 2027 and is poised to grow at a CAGR of 7.2% over the ... Burkholderia Infections Market - Key Company List by Country Premium Premium. 16. Burkholderia Infections Market - Company ... Burkholderia Infections Market Overview. Burkholderia Infections Market Size is estimated to reach $430 million by 2027 and is ... Burkholderia Infections Market Segment Analysis - by Drug The Burkholderia Infections Market based on drugs can be further ...
Multistate Outbreak of Burkholderia cepacia Infections. On July 16, 2016, FDA alerted healthcare professionals that PharmaTech ... Applying COVID-19 Infection Prevention and Control Strategies in Nursing Homes. *Guidance for Dental Settings During the COVID- ... Situational Update for Clinicians about Severe Monkeypox Virus Infections *What Clinicians Need to Know about Dengue in the ... The agency confirmed the product had been contaminated with Burkholderia cepacia, a bacteria linked to an outbreak in five ...
... antigen from Burkholderia pseudomallei, which could also diagnose Burkholderia cepacia infections. Here, considering the high ... antigen from Burkholderia pseudomallei, which could also diagnose Burkholderia cepacia infections. Here, considering the high ... Designing Probes for Immunodiagnostics : Structural Insights into an Epitope Targeting Burkholderia Infections. R. Capelli. ... Designing Probes for Immunodiagnostics : Structural Insights into an Epitope Targeting Burkholderia Infections / R. Capelli, E ...
Multistate Outbreak of Burkholderia cepacia Infections. On July 16, 2016, FDA alerted healthcare professionals that PharmaTech ... Applying COVID-19 Infection Prevention and Control Strategies in Nursing Homes. *Guidance for Dental Settings During the COVID- ... Situational Update for Clinicians about Severe Monkeypox Virus Infections *What Clinicians Need to Know about Dengue in the ... The agency confirmed the product had been contaminated with Burkholderia cepacia, a bacteria linked to an outbreak in five ...
However, not all exposure results in disease, and infection can manifest diverse outcomes. We postulate that genetic factors, ... BurkHostGEN holds the potential to discover bacterial and host genetic factors associated with melioidosis infection and ... Melioidosis is a frequently fatal disease caused by an environmental bacterium Burkholderia pseudomallei. The disease is ... protocol for evaluating variations in the Burkholderia pseudomallei and host genomes associated with melioidosis infection. ...
Burkholderia pseudomallei . Genotyping of 2,058 bacterial colonies isolated from 215 samples taken from 133 patients ... demonstrated that mixed infection is uncommon (2/133 cases [1.5%; 95% confidence interval, 0.2 to 5.3%]). ... Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis * Community engagement for the ... Simultaneous Infection with More than One Strain of Burkholderia pseudomallei Is Uncommon in Human Melioidosis ...
However, not all exposure results in disease, and infection can have different infection outcomes. Our hypothesis is that the ... BurkHostGEN holds the potential to discover bacterial and host genetic factors associated with melioidosis infection and ... Melioidosis is a frequently fatal disease caused by an environmental bacterium Burkholderia pseudomallei. The disease is ... However, not all exposure results in disease, and infection can have different infection outcomes. Our hypothesis is that the ...
... or splenous infections. B. mallei infection has a fatality rate of 95% if left untreated, and a 50% fatality rate in ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ... Bondi SK, Goldberg JB (2008). "Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei". Expert ...
Ivo Steinmetz, MD, DTMH: "Clinic, infection biology and ecology of the emerging pathogen Burkholderia pseudomallei". Friday, ...
The diagnosis of Burkholderia pseudomallei infection is based on culture of clinical specimens such as blood or other body ... Endobronchial Mass in a Patient with Burkholderia pseudomallei Infection. K L Khoo, S C Cheng, Y K Tan ... Isolated infection of the sphenoid sinus is uncommon. It usually occurs in conjunction with infection of the other paranasal ... Penicillium marneffei is a dimorphic fungus that can cause infection in immunocompromised hosts. Reports on infection with this ...
Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Cases of influenza among service members may be attributable to infections occurring before receipt of the influenza vaccine, ... 7 Continued vaccination of service members and other DOD beneficiaries is crucial to combat influenza infections and lessen ... effective at preventing influenza infection, a recent study showed that vaccination also decreased the risk of hospitalization ...
Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ...
Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Although a history of prior infection has been associated with an 84% lower risk of infection,5 subsequent reinfections have ... SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, ... The risk of having a positive test for SARS-CoV-2 after prior infection has been estimated at 14.8%, but this includes both ...
Learn about bacterial infections that can make you sick and how to treat them. ... Glanders (Burkholderia Mallei) (Centers for Disease Control and Prevention) * Leptospirosis (Centers for Disease Control and ... Shigella Infections (Shigellosis) (For Parents) (Nemours Foundation) Also in Spanish * What Are Germs? (Nemours Foundation) ... Arcanobacterium Haemolyticum Infections (American Academy of Pediatrics) Also in Spanish * Why Should I Care about Germs? ( ...
1e). Non-symbiotic bacteria, such as Bacillus subtilis and Burkholderia insecticola, cannot establish infection and symbiosis ... 1: Infection, localization and vertical transmission of E. coli in the gut symbiotic system of P. stali.. ... Infection of E. coli mutants and effects on host phenotypes. E. coli mutants were cultured, diluted and orally administrated to ... 6c). On the other hand, the infection densities of crp221T,C and ΔcyaA were not comparable to those of the improved ...
Chaparro C, Maurer J, Gutierrez C, et al. Infection with Burkholderia cepacia in cystic fibrosis: outcome following lung ... Those with primary infection (i.e. seronegative recipients who acquired infection from seropositive donors) are at greatest ... the presence of Burkholderia cepacia has been associated with a high risk of severe and often lethal postoperative infections, ... Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and ...
Author Summary Melioidosis is a severe infection caused by the environmental bacterium Burkholderia pseudomallei. Soil sampling ... Melioidosis is a severe infection caused by the environmental bacterium Burkholderia pseudomallei. Soil sampling is important ... Burkholderia pseudomallei Is the Subject Area "Burkholderia pseudomallei" applicable to this article? Yes. No. ... a rapid method for the differentiation of Burkholderia pseudomallei and Burkholderia thailandensis. Am J Trop Med Hyg 66: 759- ...
Many altogether, or one alone, secreted metalloprotease(s) would make the impact in Burkholderia cenocepacia infections Eva ...
... persistent infection with Pseudomonas aeruginosa, Burkholderia cepacia complex, or methicillin-resistant Staphylococcus aureus ...
... potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei infections. PLoS ... Increased response of IFN-γ by NK in infections by F. tularensis. Increased IFN-γ response by NK and γδ T cells in infections ... As for the analyzed inventions, they showed the use of EO in the treatment of infections by bacteria and fungi, the treatment ... A murine model of infection was also used to investigate whether EO polyphenols could mitigate parasitemia in vivo, and ...
  • Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as melioidosis. (health.mil)
  • Historically, melioidosis was a common infection in military forces serving in Southeast Asia, and it has the potential to have a serious impact on force health readiness. (health.mil)
  • Melioidosis is a potentially life threatening disease caused by the gram-negative bacterium Burkholderia pseudomallei . (health.mil)
  • Burkholderia pseudomallei, the causative agent of melioidosis, is a gram-negative bacterium capable of causing either acute lethal sepsis or chronic but eventually fatal disease in infected individuals. (tropmedres.ac)
  • BurkHostGEN: a study protocol for evaluating variations in the Burkholderia pseudomallei and host genomes associated with melioidosis infection. (ox.ac.uk)
  • BACKGROUND: Melioidosis is a frequently fatal disease caused by an environmental bacterium Burkholderia pseudomallei. (ox.ac.uk)
  • CONCLUSIONS: BurkHostGEN holds the potential to discover bacterial and host genetic factors associated with melioidosis infection and severity of illness. (ox.ac.uk)
  • Melioidosis is a frequently fatal infectious disease caused by the soil dwelling Gram-negative bacterium Burkholderia pseudomallei . (plos.org)
  • Melioidosis is a severe infection caused by the environmental bacterium Burkholderia pseudomallei . (plos.org)
  • The Gram-negative bacterium Burkholderia pseudomallei is the cause of melioidosis and a category B select agent. (plos.org)
  • Three cases of infection caused by these bacteria, which can lead to the potentially fatal melioidosis if left untreated, have been confirmed by the CDC. (latintimes.com)
  • InMAD is currently being utilized to identify candidate diagnostic antigens secreted during infection with Burkholderia pseudomallei (melioidosis), Aspergillus fumigatus (invasive aspergillosis) and Francisella tularensis (tularemia). (unr.edu)
  • Melioidosis, also called Whitmore's Disease, is a rare infectious disease caused by the bacterium Burkholderia pseudomallei. (hastingsfirm.com)
  • Burkholderia pseudomallei was isolated from the psoas abscess pus cultures and the diagnosis of melioidosis was confirmed with high titers of Burkholderia pseudomallei antibodies and positive PCR. (biomedcentral.com)
  • Melioidosis is an infection caused by Burkholderia pseudomallei, a gram negative soil and fresh water saprophyte. (biomedcentral.com)
  • Melioidosis results in a spectrum of clinical manifestations ranging from asymptomatic disease, localized skin ulcers or abscesses to fulminant disease with disseminated infection with multiple organ involvement. (biomedcentral.com)
  • The CDC requested physicians to consider melioidosis if they were presented with acute bacterial infections that did not respond to normal antibiotics and to inquire whether the affected room spray had been used. (medscape.com)
  • The Kansas Department of Health and Environment, the Texas Department of State Health Services, and the Minnesota Department of Health, with assistance from the Centers for Disease Control and Prevention (CDC), are investigating three cases of Burkholderia pseudomallei (melioidosis) infections. (cdc.gov)
  • Symptoms of melioidosis are varied and nonspecific and may include pneumonia, abscess formation, and/or blood infections. (cdc.gov)
  • Burkholderia pseudomallei , the causative agent of melioidosis, is a Tier 1 select agent external icon which can affect both animals and humans. (cdc.gov)
  • Melioidosis symptoms are nonspecific and vary depending on the type of infection. (cdc.gov)
  • To determine risk factors for acquiring Burkholderia cepacia complex among patients with cystic fibrosis (CF). (nih.gov)
  • Bcc is a group of opportunistic pathogens with relatively large genomes that can cause lethal lung infections amongst cystic fibrosis (CF) patients. (scite.ai)
  • The prevalence, epidemiology, and genomovar status of Burkholderia cepacia complex strains recovered from Italian cystic fibrosis (CF) patients were investigated using genetic typing and species identification methods. (unict.it)
  • Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
  • Infection with Burkholderia cepacia due to social contact is well described in patients with cystic fibrosis. (bmj.com)
  • Burkholderia cepacia is a well recognised pathogen in patients with cystic fibrosis, immunocompromised patients, and those undergoing mechanical ventilation. (bmj.com)
  • BACKGROUND--Burkholderia (Pseudomonas) cepacia is an increasingly important pathogen in patients with cystic fibrosis but it is unclear how it spreads from patient to patient. (whiterose.ac.uk)
  • Moreover, Burkholderia is often resistant to common antibiotics, so can be problematic for patients with cystic fibrosis - whose lungs accumulate thick mucus that the body can't readily clear - and lung transplant recipients. (bostonglobe.com)
  • Elucidating Global Epidemiology of Burkholderia Multivorans in Cases of Cystic Fibrosis by Multilocus Squence Typing. (isainsmedis.id)
  • Accurate Identification of Members of Burkholderia Cepacia Complex in Cystic Fibrosis Sputum. (isainsmedis.id)
  • Risk Factors for Burkholderia cepacia complex Bacteremia Among Intensive Care Unit Patients Withour Cystic Fibrosis : A Case Control Study. (isainsmedis.id)
  • Burkholderia species infections in patients with cystic fibrosis in British Coluumbia, Canada. (isainsmedis.id)
  • Background Infection with Burkholderia cepacia complex ( Bcc ) results in a heterogeneous clinical course ranging from asymptomatic colonization of the airways to fulminant respiratory failure in patients with cystic fibrosis (CF). Early eradication of Pseudomonas aeruginosa improves clinical outcomes. (medscape.com)
  • Burkholderia mallei was first called "Bacillus mallei" and was in the genus Pseudomonas until the early 1990s. (wikipedia.org)
  • Contaminated Eye Drops Sold at Walmart & Amazon Have Led to Reports of Infection, Loss of Vision, and Death In January of 2023, there was an outbreak of a bacteria known as Pseudomonas aeruginosa. (hastingsfirm.com)
  • Burkholderia pseudomallei, formerly known as Pseudomonas pseudomallei, is a Gram-negative bacterium. (hastingsfirm.com)
  • Despite the identification of hundreds of bacterial sRNAs, their roles on bacterial physiology and virulence remain largely unknown, as is the case of bacteria of the Burkholderia cepacia complex (Bcc). (scite.ai)
  • The agency confirmed the product had been contaminated with Burkholderia cepacia , a bacteria linked to an outbreak in five states. (cdc.gov)
  • Examples of bacteria that cause infections include Streptococcus , Staphylococcus , and E. coli . (medlineplus.gov)
  • Non-symbiotic bacteria, such as Bacillus subtilis and Burkholderia insecticola , cannot establish infection and symbiosis with P. stali 10 . (nature.com)
  • Depending on PAMP/DAMP nature and localization, autophagy can selectively capture bacteria, such event is called xenophagy, damaged organelles, and other signaling platforms activated during the infection ( 4 , 5 ). (frontiersin.org)
  • The Centers for Disease Control and Prevention (CDC) has declared Burkholderia pseudomallei, a highly dangerous bacteria with a global fatality rate of approximately 50 percent, as endemic on the U.S. Gulf Coast. (latintimes.com)
  • However, it is important to note that many individuals infected with the bacteria may not show symptoms and instead develop antibodies against it, indicating a likely higher number of infections, New York Post reported. (latintimes.com)
  • Known as Burkholderia cepacia , the bacteria was first detected in the facility three years ago, when a sample from a routine test of a patient came back positive. (bostonglobe.com)
  • Burkholderia is commonly found in water and soil, and like many bacteria, it generally poses little medical risk to healthy individuals. (bostonglobe.com)
  • We partnered with DPH and CDC to ensure patients who could potentially be vulnerable to Burkholderia were not transferred to Franciscan Children's, and that all patients transferred from Franciscan to other hospitals are first tested to prevent the spread of the bacteria," O'Brien said. (bostonglobe.com)
  • Dr. Daniel Kuritzkes, chief of the division of infectious diseases at Brigham and Women's, said providers occasionally encounter Burkholderia through routine testing of patients, but generally hold off treating them with antibiotics until there are symptoms indicating an infection, to prevent the bacteria from further developing resistance to antibiotics. (bostonglobe.com)
  • Infective Endocarditis Infective endocarditis is infection of the endocardium, usually with bacteria (commonly, streptococci or staphylococci) or fungi. (msdmanuals.com)
  • Direct infection (eg, from empyema, subphrenic or mediastinal abscess) rather than hematogenous seeding is possible with certain pyogenic bacteria (eg, Staphylococcus aureus ). (msdmanuals.com)
  • Klebsiella , Enterobacter , and Serratia Infections The gram-negative bacteria Klebsiella , Enterobacter , and Serratia are closely related normal intestinal flora that rarely cause disease in normal hosts. (msdmanuals.com)
  • Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria. (antiinfectivemeds.com)
  • Because of the development of resistance, tetracyclines are rarely used for the treatment of infections caused by common gram-negative or gram-positive bacteria unless other appropriate anti-infectives are contraindicated or are ineffective and in vitro susceptibility tests indicate that the causative organisms are susceptible to the drugs. (antiinfectivemeds.com)
  • MerLion Pharmaceuticals is addressing one of the most pressing problems in today's medicine: the need for novel and efficient anti-infectives to combat bacterial infections and amongst those in particular infectious diseases caused by antibiotic-resistant bacteria. (merlionpharma.com)
  • Five rhesus macaque monkeys at the Tulane National Primate Research Center near New Orleans have displayed possible infection from Burkholderia pseudomallei bacteria after it was somehow released from the research facility. (mysafetysign.com)
  • Burkholderia cepacia complex (BCC) is one such bacteria that can be found in water sources. (fixanywater.com)
  • To paraphrase the conclusion of Mallory's autopsy report: phage therapy is ideal to treat bacterial infections because phages are very specific and only kill the target bacteria, so they aren't dangerous or toxic. (cdc.gov)
  • The subjects were 29 patients diagnosed with Burkholderia Cepacia bacteria and performed bacterial culture at Sanglah Hospital on January 1, 2014 s.d. (isainsmedis.id)
  • ABSTRACT Central-line-associated bloodstream infection (CLABSI) is one of the most important problems in intensive care units (ICUs) worldwide. (who.int)
  • Here, considering the high phylogenetic conservation within Burkholderia species, we ask whether cross reactivity can be reciprocally displayed by the synthetic epitope from B. cenocepacia. (unimi.it)
  • My daughter Mallory would battle that superbug, Burkholderia cenocepacia , for 13 years. (cdc.gov)
  • A Functional oriT in the Ptw Plasmid of Burkholderia Cenocepacia Can Be Recognized by The R388Relaxase TrwC. (isainsmedis.id)
  • When the genomes of the bacterial strains ( Burkholderia pseudomallei ) were sequenced, they showed a high level of concordance, suggesting a common source of infection. (medscape.com)
  • Molecular typing of Burkholderia mallei strains using Whole Genome Sequencing data. (canada.ca)
  • Burkholderia cepacia is an aerobic gram-negative bacillus found in various aquatic environments. (medscape.com)
  • Tetracyclines are highly effective in the treatment of most chlamydial infections, including urogenital infections caused by Chlamydia trachomatis, respiratory tract infections caused by C. pneumoniae, respiratory tract infections caused by C. psittaci (psittacosis), and lymphogranuloma venereum caused by invasive serovars of C. trachomatis. (antiinfectivemeds.com)
  • Burkholderia cepacia is the causative agent of Burkholderia infections. (industryarc.com)
  • MLST phylogenetic tree of the outbreak Burkholderia lata from Australasian sublineage. (cdc.gov)
  • Characteristics and outcome predictors of patients involved in an outbreak of Burkholderia cepacia complex. (medscape.com)
  • Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. (medscape.com)
  • Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit. (medscape.com)
  • Signs and symptoms of B cepacia infections are related to the organ system involved and are indistinguishable from infections with other pathogens. (medscape.com)
  • We previously identified a highly immunoreactive epitope from the peptidoglycan-associated lipoprotein (Pal) antigen from Burkholderia pseudomallei, which could also diagnose Burkholderia cepacia infections. (unimi.it)
  • On August 9, 2016, FDA issued a statement alerting healthcare professionals and consumers of a voluntary nationwide recall of all liquid products manufactured by PharmaTech and distributed by the following companies: Rugby, Major, Bayshore, Metron, Centurion, and Virtus, due to possible Burkholderia cepacia contamination. (cdc.gov)
  • This study aims to determine the characteristics of Burkholderia cepacia compleks patients at RSUP Sanglah Denpasar period 2014-2016 Sanglah Hospital. (isainsmedis.id)
  • In January of 2023 the CDC issued a warning regarding EzriCare Artificial Tears lubricating eye drops, which have been linked to several serious bacterial infections across the United States. (hastingsfirm.com)
  • However, despite the clinical importance of this infection in areas where it is endemic, there is essentially no information on the mechanisms of protective immunity to the bacterium. (tropmedres.ac)
  • Tetracyclines are used for the treatment of rickettsial infections and are considered drugs of choice for Rocky Mountain spotted fever, epidemic (louse-borne) typhus, Brill-Zinsser disease, endemic (murine) typhus, scrub typhus, Q fever, and rickettsialpox. (antiinfectivemeds.com)
  • Paraplegia due to Burkholderia pseudomallei is a very rare entity encountered even in countries where the disease is endemic. (biomedcentral.com)
  • In an effort to assess the risk of B. pseudomallei infection to service personnel in Australia, 341 paired samples, representing pre- and post-deployment samples of Marines who trained in Australia, were analyzed for antibodies against B. pseudomallei antigens. (health.mil)
  • Structure-based epitope prediction drives the design of diagnostic peptidic probes to reveal specific antibodies elicited in response to infections. (unimi.it)
  • reported the rate of new infections among those with positive antibodies, even in a rigidly controlled basic training environment, to be 1.1 cases per person-year. (health.mil)
  • [ 1 ] Such infections that begin in male infants as maternal IgG antibodies, acquired transplacentally, are lost. (medscape.com)
  • Here we describe a case of Burkholderia multivorans urinary tract infection in a previously healthy man. (lu.se)
  • The infection led to urinary retention and was successfully treated with trimethoprim-sulfamethoxazole. (lu.se)
  • Because of its low renal clearance, doxycycline may not be as effective as other currently available tetracyclines for the treatment of urinary tract infections in patients with normal or impaired renal function. (antiinfectivemeds.com)
  • Finafloxacin has successfully completed a phase II trial for complicated urinary tract infections (cUTIs) including pyelonephritis, using both oral and intravenous routes of administration (tablets and solution for infusion). (merlionpharma.com)
  • There were 79 infections and the most frequent sites of infection were respiratory tract and urinary tract. (who.int)
  • We perform comparative analyses of the conformational preferences and diagnostic performances of the corresponding epitopes from the two Burkholderia species when presented in the context of the full-length proteins or as isolated peptides. (unimi.it)
  • In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species. (bvsalud.org)
  • Burkholderia cepacia complex (Bcc) is a group of 17 species that are genetically and phenotypically similiar. (isainsmedis.id)
  • Biofilm-Grown Burkholderia Cepacia Complex Cell Seuvive Antibiotic Treatment by Avoiding Production of Reactive Oxygen Species. (isainsmedis.id)
  • Antibiotic Resistance in Burkholderia Species. (isainsmedis.id)
  • Bacterial infections caused by Shigella flexneri, Salmonella typhimurium and Burkholderia pseudomallei are currently difficult to prevent due to the lack of a licensed vaccine. (ku.edu)
  • However, just as with AIDS, where there was a parallel model for the behavior of the AIDS virus in Hepatitis B, there are multiple examples of persistent bacterial infections, such as Mycobacterium tuberculosis, Salmonella typhi and Burkholderia pseudomallei. (truthout.org)
  • On August 18, 2021, FDA requested healthcare providers, healthcare facility risk managers, and procurement staff to immediately stop using and discard all ultrasound gels and lotions manufactured by Eco-Med Pharmaceutical, Inc., due to risk of bacterial contamination with Burkholderia cepacia complex. (cdc.gov)
  • As of August 18, 2021, CDC is aware of at least 59 patients in 6 states with Burkholderia stabilis infection with a bacterial strain that genetically matches the B. stabilis strain identified in 4 lots of MediChoice M500812 ultrasound gel. (cdc.gov)
  • As of August 6, 2021, preliminary testing indicates the presence of Burkholderia stabilis , a member of Bcc, in 4 lots of unopened bottles of MediChoice® M500812 ultrasound gel (Lot # B031, B040, B048, B055). (cdc.gov)
  • Geographically, North America held a dominant market share in the year 2021, owing to the increasing awareness about this disease and rising demand for diagnostic tests, driving Burkholderia Infections Market size in this region. (industryarc.com)
  • Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. (medscape.com)
  • Unfortunately, it is difficult to differentiate reinfection from 1) reactivation of the virus which persisted after the original infection (despite apparent clinical recovery), 2) persistence of non-viable viral debris, or 3) laboratory error or variation. (health.mil)
  • Multilocus Sequence Analysis reveals high genetic diversity in clinical isolates of Burkholderia Cepacia Compleks From India. (isainsmedis.id)
  • We conducted a retrospective cohort analysis of clinical outcomes compared to patients with chronic Bcc infection. (medscape.com)
  • Although passive transfer of occult infection with the transplanted organ is an additional concern, the presence of organisms on Gram stain of donor bronchial washings is not predictive of subsequent pneumonia in the recipient 4 . (ersjournals.com)
  • it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis. (msdmanuals.com)
  • In 1952, Colonel Ogden Bruton noted the absence of immunoglobulins (Ig) in a boy with a history of pneumonia and other bacterial sinopulmonary infections. (medscape.com)
  • As Bruton originally described, XLA manifests as pneumonia and other bacterial sinopulmonary infections in 80% of cases. (medscape.com)
  • Infections with group B Streptococcus , Listeria monocytogenes, or gram-negative rods (eg, Escherichia coli, Klebsiella pneumoniae ) are common causes of bacterial pneumonia. (medscape.com)
  • Burkholderia are opportunistic pathogens. (lu.se)
  • Bcc is an opportunistic pathogen in which it will cause an infection in a person who has had a previous severe lung infection or a person with a weak immune system. (isainsmedis.id)
  • The primary route of infection with B. pseudomallei is believed to be through skin inoculation of the soil-dwelling bacterium. (health.mil)
  • Bacterial infections of the lower respiratory tract comprise the majority of infectious complications and have a bimodal temporal distribution. (ersjournals.com)
  • In the early '80s, the medical establishment thought they knew everything about infectious disease, so when AIDS came along, researchers insisted that it could not be an infection. (truthout.org)
  • Patients have developed Bcc infections, including bloodstream infections, after likely having undergone ultrasound-guided procedures in which MediChoice ® M500812 ultrasound gel was used. (cdc.gov)
  • Additional laboratory testing of isolates or specimens from patients with reported Bcc infections and of additional lots of MediChoice® M500812 ultrasound gel is currently underway. (cdc.gov)
  • A case-control study was conducted with active surveillance for B cepacia complex colonization/infection among patients at 21 CF centers from April 1986 to March 1989 (study period). (nih.gov)
  • B cepacia also may cause central venous catheter-related infections in patients with cancer and in those on hemodialysis. (medscape.com)
  • Patients with lung diseases such as asthma, CFTR and COPD are at substantial risk of suffering from Burkholderia infection. (industryarc.com)
  • In addition to the recalled liquid products manufactured by PharmaTech, CDC and FDA continue to recommend that clinicians and patients not use any brand of liquid docusate sodium product as a stool softener or for any other medical purpose, as some of the infections reported identify docusate sodium products manufactured by other companies other than PharmaTech. (cdc.gov)
  • Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
  • In one large contact tracing study in Korea, for example, 285 patients were found to have persistent positive results for up to 12 weeks after initial infection, but the Korea Centers for Disease and Prevention (KCDC) found no evidence of transmissibility or ability to isolate replication-competent virus. (health.mil)
  • The Xpert Xpress SARS-CoV-2 utilizes real-time reverse-transcription polymerase chain reaction (qRT-PCR) testing for qualitative and quantitative detection of viral nucleic acid from patients suspected of infection with the SARS-CoV-2 virus. (health.mil)
  • An extensive experience accrued to date in transplanting CF patients has generally allayed these concerns, demonstrating arate of bacterial pulmonary infections similar to that encountered in other patient populations 5 . (ersjournals.com)
  • 1 Rare cases of acute non-pulmonary B cepacia infection have also been described in immunocompetent patients. (bmj.com)
  • Although used in hopes of reducing the likelihood of infection in patients, many products have been identified as the source of infection in several outbreaks, sometimes due to the nonsterile nature of the many readily available antiseptics. (biomedcentral.com)
  • The purpose of this article is to begin the discussion of the importance of targeting use of skin antiseptic products in hospitalized patients to reduce the likelihood of infection, and also introduce the salient concepts surrounding infection, skin antisepsis, and contamination of antiseptic products. (biomedcentral.com)
  • In light of the ongoing clusters, the hospital is currently not accepting transfers of patients with lung transplants, who are particularly vulnerable to infection. (bostonglobe.com)
  • Burkholderia is known to cause infections in hospitalized patients, including a 2020 cluster at Brigham and Women's Hospital that led to the deaths of three patients in its cardiothoracic intensive care unit. (bostonglobe.com)
  • Of 2,390 patients tracked in the report, 28 died as a direct result of their infections. (bostonglobe.com)
  • In one limited study in patients with confirmed C. burnetti infection and chronic endocarditis, a regimen of doxycycline and hydroxychloroquine was associated with a lower relapse rate than a regimen of doxycycline and ofloxacin. (antiinfectivemeds.com)
  • Such infections sician, the nurse manager of the unit and are associated with a high morbidity Patients an infection control nurse. (who.int)
  • We describe here a murine model of either acute or chronic infection with B. pseudomallei in Taylor Outbred (TO) mice which mimics many features of the human pathology. (tropmedres.ac)
  • In contrast, at lower doses mice were able to clear the inoculum from the liver and spleen over a 3- to 4-week period, but persistence of the organism at other sites resulted in a chronic infection of between 2 and 16 months duration which was eventually lethal in all of the animals tested. (tropmedres.ac)
  • The rapid production of IFN-gamma within the first day of infection determines whether the infection proceeds to an acute lethal outcome or becomes chronic. (tropmedres.ac)
  • The Burkholderia Infections Market is predicted to increase owing to the growing prevalence of chronic lung diseases across the world fuelling the growth of the Burkholderia Infections Market. (industryarc.com)
  • Dr. Conant got involved with Lyme when he began noticing that the medical establishment did not believe in "chronic Lyme disease" - a term used to describe the notion that the Lyme bacterial infection can persist past the recommended 2 to 4 weeks of antibiotic treatment. (truthout.org)
  • Lung abscess is a necrotizing lung infection characterized by a pus-filled cavitary lesion. (msdmanuals.com)
  • At least 48 of these cases are bloodstream infections, and many had undergone ultrasound-guided procedures prior to their infections. (cdc.gov)
  • Infection control are an estimated 80 000 catheter-related 2013 and who received a central venous strategies that were previously used for bloodstream infections, with 28 000 catheter were prospectively included the prevention of CLABSI were put deaths every year. (who.int)
  • Environmental sampling is important to identify geographical distribution of the organism and related risk of infection to humans and livestock. (plos.org)
  • We are focused on the development of novel antibiotics to combat the evolving threat of bacterial infections in humans and animals. (merlionpharma.com)
  • Along with this, the ability to escape from endocytic vesicles into the cytoplasm and subsequent intracellular replication and cell to cell spread by actin based motility and induction of cell fusion are important characteristics of this infection. (biomedcentral.com)
  • Identify the growth characteristics of Burkholderia pseudomallei . (cdc.gov)
  • The increasing prevalence of lung diseases is anticipated to fuel the growth of the Burkholderia infections industry. (industryarc.com)
  • This study aimed to estimate the prevalence and risk factors for health-care-associated infection (HAI) in all 9 hospitals of the central-east area of Tunisia in 2005. (who.int)
  • 7 Furthermore, belief that previous infection with SARS-CoV-2 leads to immunity from reinfection may result in behaviors which increase the likelihood of transmission and infection, including hesitancy and delays in vaccination. (health.mil)
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • Yet, because of the historical belief that the Lyme infection is always eradicated with a 2 to 4 week course of antibiotics, researchers have remained frozen in their stance that there is no such thing as a persistent infection. (truthout.org)
  • In this scenario, healthcare-associated infections may occur, leaving the patient at higher risk of mortality and increasing costs of care substantially. (biomedcentral.com)
  • However, the lack of proper diagnostic techniques in Low and Middle-Income Countries (LMICs) may limit the Burkholderia Infections Industry growth over the forecast period 2022-2027. (industryarc.com)
  • It is highly likely that this infection is under diagnosed in developing countries where diagnostic facilities are minimal. (biomedcentral.com)
  • In contrast, the presence of Burkholderia cepacia has been associated with a high risk of severe and often lethal postoperative infections, and consequently, with inferior survival rates. (ersjournals.com)
  • Thus, XLA is most likely to be diagnosed when unusually severe or recurrent sinopulmonary infections occur in a male infant younger than 1 year. (medscape.com)
  • However, it can trigger infections and other illnesses in medically compromised people. (bostonglobe.com)
  • Similarly, with Lyme disease, the medical profession has been holding fast to the belief that persistent symptoms beyond the recommended treatment can't be due to an ongoing infection. (truthout.org)
  • Health care professionals in Sri Lanka, where this is an emerging infection, need to improve their knowledge regarding this disease and should have high degree of suspicion to make a correct and a timely diagnosis to reduce the morbidity and mortality due to Burkholderia pseudomallei infection. (biomedcentral.com)
  • However, not all exposure results in disease, and infection can manifest diverse outcomes. (ox.ac.uk)
  • FDA Issues Warning to Consumers Using EzriCare or Delsam Pharma's Artificial Tears The U.S. Food and Drug Administration (FDA) has partnered with the Center for Disease Control (CDC) and state and local health departments after a number of infections were linked to the use of EzriCare or Delsam Pharma's Artificial Tears eye drops. (hastingsfirm.com)
  • Trimethoprim & Sulfamethoxazole is a commonly used drugs for the treatment of Burkholderia Infections. (industryarc.com)
  • Yilmaz T, Celik I, Cihangiroglu M, Yildirim S, Akbulut A. Burkholderia cepacia: An unusual cause of postoperative endophthalmitis. (medscape.com)
  • Analysis of pre- and post-deployment serum samples obtained from the Department of Defense Serum Repository identified serological evidence of possible infection with B. pseudomallei in U.S. Marines who trained in Australia during 2012-2014. (health.mil)
  • Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and late mortality. (ersjournals.com)
  • Microbiological Assesment of Burkholderia cepacia complex (Bcc) Isolates in Alexandria Main University Hospital. (isainsmedis.id)
  • La présente étude visait à estimer la prévalence et les facteurs de risque des infections liées aux procédures de soins dans tous les hôpitaux de la région du centre-est de la Tunisie, comptant neuf établissements, en 2005. (who.int)
  • Une analyse de régression logistique multiple a indiqué que les infections associées aux procédures de soins étaient liées aux variables suivantes : diabète (OR = 2,0), immunodépression (OR = 3,3), durée du séjour (OR = 4,5), pose d'un cathéter veineux central (OR = 2,5) ou d'un cathéter veineux périphérique (OR = 10,2). (who.int)
  • RÉSUMÉ Les infections sur cathéter central sont l'un des problèmes les plus importants dans les unités de soins intensifs au niveau mondial. (who.int)
  • Un ensemble de soins dispensés en cas d'infections sur cathéter central a été introduit dans une unité de soins intensifs médicaux et chirurgicaux de 13 lits à Kocaeli (Turquie) en janvier 2010. (who.int)
  • Le retour d'information fourni au personnel a permis de renforcer la culture de la sécurité du patient en unité de soins intensifs. (who.int)
  • La mise en oeuvre de cet ensemble de soins concernant les cathéters centraux, associée à l'accent mis sur le degré d'application de toutes ses composantes et une culture de la sécurité du patient, a permis d'atteindre et de maintenir un taux zéro d'infection sur cathéter central dans cette unité de soins intensifs. (who.int)
  • Discuss standardized laboratory tests used to isolate and identify Burkholderia pseudomalle i. (cdc.gov)
  • People with diabetes or kidney and liver issues are particularly vulnerable to the infection. (latintimes.com)
  • It can lead to serious infections in vulnerable individuals. (fixanywater.com)