Infections with bacteria of the genus BURKHOLDERIA.
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.
A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.
A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.
A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.
A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.
A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.
A species of gram-negative bacteria parasitic on HORSES and DONKEYS causing GLANDERS, which can be transmitted to humans.
Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Inflammation of an INTERVERTEBRAL DISC or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
A disease of horses and donkeys caused by Trypanosoma equiperdum. The disease occurs in Africa, the Americas, and Asia.
The largest of the auditory ossicles, and the one attached to the membrana tympani (TYMPANIC MEMBRANE). Its club-shaped head articulates with the INCUS.
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
Substances that reduce the growth or reproduction of BACTERIA.
The state of being engaged in an activity or service for wages or salary.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.

Comparison of isolation media for recovery of Burkholderia cepacia complex from respiratory secretions of patients with cystic fibrosis. (1/346)

Burkholderia cepacia selective agar (BCSA) has previously been devised for isolation of B. cepacia from respiratory secretions of patients with cystic fibrosis and tested under research laboratory conditions. Here we describe a study in which BCSA, oxidation-fermentation polymyxin bacitracin lactose agar (OFPBL), and Pseudomonas cepacia agar (PCA) were compared in routine culture procedures for the ability to grow B. cepacia and inhibit other organisms. Three hundred twenty-eight specimens from 209 patients at two pediatric centers and 328 specimens from 109 adults were tested. Plates were inoculated, incubated, and read for quality and quantity of growth at 24, 48, and 72 h. Five (1.5%) specimens from 4 (1.9%) children and 75 (22.9%) specimens from 16 (14.7%) adults grew B. cepacia complex. At 24, 48, and 72 h, BCSA achieved 43, 93, and 100% detection, respectively; OFPBL achieved 26, 84, and 96%, respectively; and PCA achieved 33, 74, and 84% detection, respectively. Quality was assessed as pinpoint or good growth. At 24 h, most cultures growing B. cepacia complex had pinpoint colonies. By 48 and 72 h, 48 and 69% of B. cepacia complex cultures, respectively, had good growth on BCSA, while on OFPBL 19 and 30%, respectively, had good growth and on PCA 11 and 18%, respectively, had good growth. BCSA was superior to OFPBL and PCA in suppressing organisms other than B. cepacia complex; 40 non-B. cepacia complex organisms were isolated from BCSA, 263 were isolated from OFPBL, and 116 were isolated from PCA. We conclude that BCSA is superior to OFPBL and PCA in its ability to support the growth of B. cepacia complex and to suppress other respiratory organisms.  (+info)

Structural elucidation of a novel exopolysaccharide produced by a mucoid clinical isolate of Burkholderia cepacia. Characterization of a trisubstituted glucuronic acid residue in a heptasaccharide repeating unit. (2/346)

The structure of the exopolysaccharide (EPS) produced by a clinical isolate of Burkholderia cepacia isolated from a patient with fibrocystic lung disease has been investigated. By means of methylation analyses, carboxyl reduction, partial depolymerization by fuming HCl and chemical degradations such as Smith degradation, lithiumethylenediamine degradation and beta-elimination, supported by GC/MS and NMR spectroscopic analyses, the repeat unit of the EPS has been identified and was shown to correspond to the acidic branched heptasaccharide with the following structure: [formula: see text]. This partially acetylated acidic polymer, distinguished by the presence of the less usual D-isomer of rhamnose and of a trisubstituted glucuronic acid residue, could represent the main EPS produced by this bacterial species.  (+info)

An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. (3/346)

Burkholderia cepacia is an important pathogen in cystic fibrosis (CF) and an infrequent cause of nosocomial infection in non-CF patients. This report describes a large hospital outbreak that appeared to involve both patient groups, a previously unrecognized phenomenon. Ribotype restriction fragment length polymorphism (RFLP) profiles and pulsed-field gel electrophoresis-resolved macrochromosomal RFLPs were analyzed, a ribotype-based phylogenic tree was constructed, and case-control and cohort studies were performed. A single dominant clone was found in both CF and non-CF groups. Phylogenic analysis suggests that it has evolved independently and that such highly transmissible strains can emerge rapidly and randomly. Acquisition risk in the CF patients was linked to hospitalization (odds ratio=5.47, P=.0158, confidence interval=1. 28-26.86) and was associated with significantly increased mortality rates. Infection control policies must now consider this threat of transmission between non-CF and CF patients.  (+info)

Identification of Burkholderia spp. in the clinical microbiology laboratory: comparison of conventional and molecular methods. (4/346)

Cystic fibrosis (CF) predisposes patients to bacterial colonization and infection of the lower airways. Several species belonging to the genus Burkholderia are potential CF-related pathogens, but microbiological identification may be complicated. This situation is not in the least due to the poorly defined taxonomic status of these bacteria, and further validation of the available diagnostic assays is required. A total of 114 geographically diverse bacterial isolates, previously identified in reference laboratories as Burkholderia cepacia (n = 51), B. gladioli (n = 14), Ralstonia pickettii (n = 6), B. multivorans (n = 2), Stenotrophomonas maltophilia (n = 3), and Pseudomonas aeruginosa (n = 11), were collected from environmental, clinical, and reference sources. In addition, 27 clinical isolates putatively identified as Burkholderia spp. were recovered from the sputum of Dutch CF patients. All isolates were used to evaluate the accuracy of two selective growth media, four systems for biochemical identification (API 20NE, Vitek GNI, Vitek NFC, and MicroScan), and three different PCR-based assays. The PCR assays amplify different parts of the ribosomal DNA operon, either alone or in combination with cleavage by various restriction enzymes (PCR-restriction fragment length polymorphism [RFLP] analysis). The best system for the biochemical identification of B. cepacia appeared to be the API 20NE test. None of the biochemical assays successfully grouped the B. gladioli strains. The PCR-RFLP method appeared to be the optimal method for accurate nucleic acid-mediated identification of the different Burkholderia spp. With this method, B. gladioli was also reliably classified in a separate group. For the laboratory diagnosis of B. cepacia, we recommend parallel cultures on blood agar medium and selective agar plates. Further identification of colonies with a Burkholderia phenotype should be performed with the API 20NE test. For final confirmation of species identities, PCR amplification of the small-subunit rRNA gene followed by RFLP analysis with various enzymes is recommended.  (+info)

Differentiation of Burkholderia species by PCR-restriction fragment length polymorphism analysis of the 16S rRNA gene and application to cystic fibrosis isolates. (5/346)

Burkholderia cepacia, which is an important pathogen in cystic fibrosis (CF) owing to the potential severity of the infections and the high transmissibility of some clones, has been recently shown to be a complex of five genomic groups, i.e., genomovars I, II (B. multivorans), III, and IV and B. vietnamiensis. B. gladioli is also involved, though rarely, in CF. Since standard laboratory procedures fail to provide an accurate identification of these organisms, we assessed the ability of restriction fragment length polymorphism (RFLP) analysis of amplified 16S ribosomal DNA (rDNA), with the combination of the patterns obtained with six endonucleases, to differentiate Burkholderia species. This method was applied to 16 type and reference strains of the genus Burkholderia and to 51 presumed B. cepacia clinical isolates, each representative of one clone previously determined by PCR ribotyping. The 12 Burkholderia type strains tested were differentiated, including B. cepacia, B. multivorans, B. vietnamiensis, and B. gladioli, but neither the genomovar I and III reference strains nor the genomovar IV reference strain and B. pyrrociniaT were distinguishable. CF clinical isolates were mainly distributed in RFLP group 2 (which includes B. multivoransT) and RFLP group 1 (which includes B. cepacia genomovar I and III reference strains, as well as nosocomial clinical isolates). Two of the five highly transmissible clones in French CF centers belonged to RFLP group 2, and three belonged to RFLP group 1. The remaining isolates either clustered with other Burkholderia species (B. cepacia genomovar IV or B. pyrrocinia, B. vietnamiensis, and B. gladioli) or harbored unique combinations of patterns. Thus, if further validated by hybridization studies, PCR-RFLP of 16S rDNA could be an interesting identification tool and contribute to a better evaluation of the respective clinical risks associated with each Burkholderia species or genomovar in patients with CF.  (+info)

Analysis of fliC variation among clinical isolates of Burkholderia cepacia. (6/346)

PCR and restriction fragment length polymorphism (RFLP) typing of flagellin genes (fliC) from 57 clinical isolates of Burkholderia cepacia indicated that only type 11 flagellins were present. Twenty-two isolates previously identified as the epidemic UK cystic fibrosis strain were indistinguishable by this method, as were 11 isolates from a pseudo-outbreak in Senegal. Other clinical isolates, including 19 from disparate sources in Malaysia, were separated into nine fliC RFLP groups, exhibiting a large degree of divergence. When isolates were indistinguishable by fliC genotyping, their similarity was confirmed by whole genome macro-restriction analysis with pulsed-field gel electrophoresis following XbaI digestion. The variation in fliC sequences of B. cepacia was far greater than that with B. pseudomallei, supporting the view that 'B. cepacia', as currently defined, may comprise several different genomic species.  (+info)

A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen. (7/346)

Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon knockout (GKO) BALB/c mice to facilitate dissection of components of pathogenicity and host defense. Both WT and GKO mice were susceptible to chronic splenic infection with B. cepacia, but not with Pseudomonas aeruginosa. B. cepacia strains from patients with CGD persisted longer than those from CF patients. C57BL/6 mice were the most susceptible murine strain; bacteria persisted in the spleen for 2 months. DBA/2, BALB/c, and A/J strains of mice were relatively resistant to infection. Certain strains of B. cepacia complex can persist in the murine spleen after systemic infection; this may provide clues to its virulence in compromised hosts, such as those with CGD and CF.  (+info)

Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebae. (8/346)

Members of the taxonomically diverse Burkholderia cepacia complex have become a major health risk for patients with cystic fibrosis (CF). Although patient-to-patient transmission of B. cepacia strains has been well-documented, very little is known about possible vehicles of transmission and reservoirs for these micro-organisms. In this work, it is shown that strains of the B. cepacia complex can survive within different isolates of the genus Acanthamoeba. Trophozoites containing bacteria developed profuse cytoplasmic vacuolization. Vacuolization was not detected in trophozoites infected with live Escherichia coli or heat-killed B. cepacia, or by incubation of trophozoites with filter-sterilized culture supernatants, indicating that metabolically active intracellular bacteria are required for the formation of vacuoles. Experiments with two different B. cepacia strains and two different Acanthamoeba isolates revealed that bacteria display a low level of intracellular replication approximately 72-96 h following infection. In contrast, extracellular bacteria multiplied efficiently on by-products released by amoebae. The findings suggest that amoebae may be a reservoir for B. cepacia and possibly a vehicle for transmission of this opportunistic pathogen among CF patients.  (+info)

In this study, we compare our results for a G. mellonella infection model with previously published BCC data from other infection models, taking care to use many of the identical BCC strains previously tested in order to ensure valid comparison. We observed that G. mellonella, as an infection model for the BCC, possessed several advantages over other infection models. Using G. mellonella, we obtained similar results to both mouse and other alternative infection models with identical BCC strains. In our experience, no other alternative infection models as tested were as sensitive, accurate (with respect to mice and rat lung model results), or as robust or simple to use as the G. mellonella model. This was despite the fact G. mellonella possesses a relatively complex innate immune response, which is lacking in plant infection models. Furthermore, due to ethical and regulatory issues, it is now difficult to perform LD50 experiments with mice. In addition, amoebae and C. elegans are somewhat more ...
This study aimed firstly to establish the distribution and copy number within the Burkholderia cepacia complex of three insertion sequences (IS402, IS407 and IS1416) that possess the ability to activate transcription and hence influence gene expression. A second aim was to map the genomic insertion sites of one of the active insertion sequences (IS407) to establish putative links between insertion site and downstream gene activation. The resulting data revealed that all three insertion sequences were present in one-third of the 66 isolates tested. The three insertion sequences were prevalent across the nine B. cepacia complex species, although IS402 was absent from the 16 Burkholderia anthina strains tested and IS407 was absent from all 10 Burkholderia pyrrocinia strains. IS407 copies from six strains (two Burkholderia cenocepacia strains and one strain each of Burkholderia multivorans, Burkholderia stabilis, Burkholderia vietnamiensis and B. anthina) were mapped to the genome using hemi-nested inverse
Glowicz J, Crist M, Gould C, Moulton-Meissner H, Noble-Wang J, de Man TJB, Perry KA, Miller Z, Yang WC, Langille S, Ross J, Garcia B, Kim J, Epson E, Black S, Pacilli M, LiPuma JJ, Fagan R, B. cepacia Investigation Workgroup. 2018. A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. Am J Infect Control 46:649-655.. Brooks RB, Mitchell PK, Miller JR, Vasquez AM, Havlicek J, Lee H, Quinn M, Adams E, Baker D, Greeley R, Ross K, Daskalaki I, Walrath J, Moulton-Meissner H, Crist MB, Burkholderia cepacia Workgroup. 2018. Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure to Contaminated Saline Flush Syringes - United States, 2016-2017. Clin Infect Dis Off Publ Infect Dis Soc Am.. Becker SL, Berger FK, Feldner SK, Karliova I, Haber M, Mellmann A, Schäfers H-J, Gärtner B. 2018. Outbreak of Burkholderia cepacia complex infections associated with ...
Cystic fibrosis (CF) is a recessive genetic disease characterized by chronic respiratory infections and inflammation causing permanent lung damage. Recurrent infections are caused by Gram-negative antibiotic-resistant bacterial pathogens such as Pseudomonas aeruginosa, Burkholderia cepacia complex (Bcc) and the emerging pathogen genus Pandoraea. In this study, the interactions between co-colonizing CF pathogens were investigated. Both Pandoraea and Bcc elicited potent pro-inflammatory responses that were significantly greater than Ps. aeruginosa. The original aim was to examine whether combinations of pro-inflammatory pathogens would further exacerbate inflammation. In contrast, when these pathogens were colonized in the presence of Ps. aeruginosa the pro-inflammatory response was significantly decreased. Real-time PCR quantification of bacterial DNA from mixed cultures indicated that Ps. aeruginosa significantly inhibited the growth of Burkholderia multivorans, Burkholderia cenocepacia, Pandoraea
TY - CONF. T1 - Comparison of biofilm formation between Burkholderia multivorans Burkholderia cenocepacia Pseudomonas aeruginosa in the presence or absence of mucin. AU - Einarsson, Gisli. AU - McDowell, Andrew. AU - Elborn, Joseph. AU - Martin, Lorraine. PY - 2009/6. Y1 - 2009/6. M3 - Paper. SP - S34-S34. T2 - European Cystic Fibrosis Conference. Y2 - 1 June 2009 through 1 June 2009. ER - ...
1. Cystic Fibrosis Patient Registry, 2012 Annual Data Report Bethesda, MD: Cystic Fibrosis Foundation; 2013.. 2. Aaron SD, Ferris W, Henry DA, Speert DP, Macdonald NE. Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia. American journal of respiratory and critical care medicine 2000;161:1206-12. [PubMed]. 3. Aaron SD, Vandemheen KL, Ferris W, Fergusson D, Tullis E, Haase D, Berthiaume Y, Brown N, Wilcox P, Yozghatlian V, Bye P, Bell S, Chan F, Rose B, Jeanneret A, Stephenson A, Noseworthy M, Freitag A, Paterson N, Doucette S, Harbour C, Ruel M, MacDonald N. Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial. Lancet 2005;366:463-71. [PubMed]. 4. Avgeri SG, Matthaiou DK, Dimopoulos G, Grammatikos AP, Falagas ME. Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
CONCLUSION: Rarely, B. cepacia may be the offending organism resulting in a postoperative lumbar PS.PMID:33948309 | PMC:PMC8088530 | DOI:10.25259/SNI_518_2020...
Pathogenic Burkholderia rely on host factors for efficient intracellular replication and are highly refractory to antibiotic treatment. To identify host genes that are required by Burkholderia spp. during infection, we performed a RNA interference (RNAi) screen of the human kinome and identified 35 host kinases that facilitated Burkholderia thailandensis intracellular survival in human monocytic THP-1 cells. We validated a selection of host kinases using imaging flow cytometry to assess efficiency of B. thailandensis survival in the host upon siRNA-mediated knockdown. We focused on the role of the novel protein kinase C isoform, PKC-η, in Burkholderia infection and characterized PKC-η/MARCKS signaling as a key event that promotes the survival of unopsonized B. thailandensis CDC2721121 within host cells. While infection of lung epithelial cells with unopsonized Gram-negative bacteria stimulated phosphorylation of Ser175/160 in the MARCKS effector domain, siRNA-mediated knockdown of PKC-η ...
The affected persons involved eight males and one female aged 46 to 69, who were admitted to Caritas Medical Centre from February 2017 to August 2018 respectively for management. Among them, seven were discharged, one remains hospitalized and one passed away in 2017.. The clinical diagnoses of the patients were infective spondylitis (4), sepsis (2), septic arthritis (2) and infective endocarditis (1).. Separately, the Burkholderia cepacia isolates from seven of the nine patients were found to be genetically identical upon laboratory testing.. Preliminary investigation revealed that all affected patients were people who injected drugs. Investigations are ongoing, a health department spokesman said.. Burkholderia cepacia is a bacteria which are commonly found in water, soil, and moist environments. It is generally not pathogenic to healthy person but those who have weakened immune system or chronic lung diseases may be more susceptible to infection with the bacteria.. The spokesman appealed that ...
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
The cciIR quorum-sensing system associated with epidemic strains of B. cenocepacia is involved in the regulation of known virulence factors and is a part of a regulatory network with the cepIR quorum-sensing system, since CepR is required for cciIR expression. Phylogenetic analysis demonstrated that the cepIR and cciIR systems are highly distinct. The cepIR system that is widely distributed among the Bcc was predicted to be the ancestral system, whereas the cciIR system was likely acquired by horizontal gene transfer when cci was incorporated into the B. cenocepacia genome. The presence of an ancestral and a more-recently acquired AHL-dependent quorum-sensing system has been observed in other species. The P. aeruginosa lasIR system is considered to be the ancestral system, and the rhlIR system is considered to be more recently acquired (22). The rhlIR system has been incorporated into the regulatory pathway of the lasIR system and is dependent on the lasIR system for expression (21, 34). Both of ...
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to ...
AbstractBackground Burkholderia cepacia complex (BCC) bacteria are opportunistic pathogens that cause severe lung infections in cystic fibrosis (CF). Treatment of BCC infections is difficult due to the inherent multidrug resistance of BCC. There is a pressing need to find new bacterial targets for antimicrobials. We have previously shown that the novel compound Q22, which is related to A22 and inhibits the bacterial cytoskeletal protein MreB, inhibits growth of BCC bacteria.Aims We aimed to further analyse the phenotypic effects of Q22 treatment on BCC virulence traits to assess its feasibility as an antimicrobial.Methods BCC bacteria were grown in the presence of Q22 and a broad phenotypic analysis was performed, including resistance to H2O2 induced oxidative stress, changes in inflammatory potential of cell surface components and in vivo drug toxicity studies. The influence of Q22 treatment on inflammatory potential was measured by monitoring the cytokine responses of BCC whole cell lysates, ...
Nurse Assist voluntarily recalled its I.V. Flush Syringes after becoming aware of patients that developed Burkholderia cepacia bloodstream infections while receiving intravenous care using prepackaged saline flushes from Nurse Assist. Nurse Assist is notifying its distributors and customers via email, phone call, and certified mail. Customers will receive instructions for returning product. For freight collect shipping information, please contact the Customer Service Team at 1-800-649-6800 ext. 10.. Nurse Assist is actively investigating the possible link to the infections with the Food and Drug Administration, the U.S. Centers for Disease Control, and various state health departments to ensure that the products are safe for their intended use. Until an investigation can be completed, Nurse Assist urges all healthcare facilities with affected product to discontinue use and return the product to the supplier.. Consumers with questions may contact the company via telephone at 1-800-649-6800 ext. ...
McNamara, Christopher J.; Leff, Laura Gunn (2002). In Situ Hybridization of Burkholderia Cepacia Cells. Humana Press 187-192. doi: 10.1385/1-59259-238-4:187. Retrieved from https://oaks.kent.edu/bscipubs/ ...
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November 11, 2014 by: Julie Wilson staff writer (NaturalNews) Ten brands of baby wipes produced by the Pennsylvania-based Nutek Disposables, Inc., were recalled on October 25, 2014, following complaints of foul odor and discoloration. Upon further testing, the baby wipe and adult washcloth manufacturer discovered that some of their products contained Burkholderia cepacia, a…
Étude de stabilité physico-chimique dune solution de cloxacilline à 250 mg/mL en seringues polypropylène et à 50-100 mg/mL en diffuseurs portables. Synprefh Congress (Hopipharm), 2020 ...
Étude de stabilité physico-chimique dune solution de cloxacilline à 250 mg/mL en seringues polypropylène et à 50-100 mg/mL en diffuseurs portables. Synprefh Congress (Hopipharm), 2020 ...
The Burkholderia cepacia complex consists of nine closely related species: Burkholderia cepacia genomovars I and VI, Burkholderia multivorans (genomovar II), Burkholderia cenocepacia (genomovar III), Burkholderia stabilis (genomovar IV), Burkholderia vietnamiensis (genomovar V), Burkholderia ambifaria (genomovar VII), Burkholderia anthina (genomovar VIII), and Burkholderia pyrrocinia (genomovar IX) (2, 9, 10). Despite the advances that have been made in the understanding of the taxonomy and epidemiology of this group, infections of the respiratory tract with B. cepacia complex organisms still have a considerable impact on morbidity and mortality in cystic fibrosis (CF) patients (4, 5, 6). B. cepacia complex strains have also attracted attention as possible biocontrol and bioremediation agents that could be used as antagonists of soil-borne plant pathogens, as plant growth-promoting agents, and for the bioremediation of various recalcitrant xenobiotics (3, 8). To aid in identification, ...
At the beginning of this review it is essential to clarify the terminology that will be used to refer to the members of the Burkholderia cepacia complex and their relatives. The name B. cepacia will relate only to B. cepacia genomovar I. Strains resembling B. cepacia may belong to the B. cepacia complex, to otherBurkholderia species (for instance, Burkholderia gladioli), or to species from other genera (for instance,Ralstonia pickettii) that share some phenotypic or genotypic similarities with the B. cepacia complex. B. cepacia complex bacteria and organisms that may be confused with them will be altogether referred to as B. cepacia-like organisms. Most previous reports regarding these organisms were published before the recognition of the complicated taxonomic relationships between the different members of the B. cepacia complex; it is therefore unclear to what category the presumed B. cepacia isolates described would belong. For that reason, when such literature is cited, the name B. cepacia ...
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B. cepacia complex bacteria can form biofilms, not only on abiotic surfaces (e.g., glass and plastics), but also on biotic surfaces such as epithelial cells, leading to the suggestion that biofilm formation plays a key role in persistent infection of cystic fibrosis lungs. This article presents an overview of the molecular mechanisms involved in B. cepacia complex biofilm formation, the increased resistance of sessile B. cepacia complex cells and the role of quorum sensing in B. cepacia complex biofilm formation.
TY - JOUR. T1 - A Decade of Burkholderia cenocepacia Virulence Determinant Research. AU - Loutet, S.A.. AU - Valvano, Miguel. PY - 2010/10. Y1 - 2010/10. N2 - The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases. These infections are difficult to treat due to the inherent resistance of the bacteria to antibiotics. Bacteria can spread between CF patients through social contact and sometimes cause cepacia syndrome, a fatal pneumonia accompanied by septicemia. Burkholderia cenocepacia has been the focus of attention because initially it was the most common Bcc species isolated from patients with CF in North America and Europe. Today, B. cenocepacia, along with Burkholderia multivorans, is the most prevalent Bcc species in patients with CF. Given the progress that has been made in our understanding of B. cenocepacia over the past decade, we ...
Bacteria of the Burkholderia cepacia complex (Bcc) are pathogens of humans, plants, and animals. Burkholderia cenocepacia is one of the most common Bcc species infecting cystic fibrosis (CF) patients and its carriage is associated with poor prognosis. In this study, we characterized a general O-link …
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function. Because of the resistance of BCC to many antibiotics, treatment options are often limited. New therapies to improve outcomes for patients infected with BCC are needed.. However, because of the unpredictable nature of this pulmonary infection in CF, patients with BCC infection have been excluded from many CF therapeutic trials.. Recent published trials in the United States, Australia, and the United Kingdom have all demonstrated clinical benefits from prolonged administration of azithromycin in CF. In these trials, the vast majority of patients were chronically infected with Pseudomonas aeruginosa.. Patients with BCC were excluded from the US and UK trials, and only four patients with BCC infection were enrolled in the Australian trial. Thus, the effectiveness of azithromycin in CF patients infected with BCC is largely unknown and deserves further ...
ID CP000871; SV 1; circular; genomic DNA; STD; PRO; 167422 BP. XX AC CP000871; AAVB01000000-AAVB01000037; XX PR Project:PRJNA17407; XX DT 16-NOV-2007 (Rel. 93, Created) DT 12-DEC-2013 (Rel. 119, Last updated, Version 2) XX DE Burkholderia multivorans ATCC 17616 plasmid pBMUL01, complete sequence. XX KW . XX OS Burkholderia multivorans ATCC 17616 OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex. OG Plasmid pBMUL01 XX RN [1] RP 1-167422 RG US DOE Joint Genome Institute RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., RA Richardson P.; RT Complete sequence of plasmid1 of Burkholderia multivorans ATCC 17616; RL Unpublished. XX RN [2] RP 1-167422 RG US DOE Joint Genome Institute RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., ...
Regan KH, Bhatt J. Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD009876. DOI: 10.1002/14651858.CD009876.pub3 ...
Burkholderia cepacia complex (Bcc) গ্রাম নেগেটিভ, অ্যারোবিক (অক্সিজেনের উপস্থিতিতে বাঁচতে পারে) ব্যাক্টেরিয়া
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Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective therapeutic treatments are lacking. In this study, we showed that CpG administration increased survival, demonstrating protection in the murine glanders model. Bacterial recovery from infected lungs, liver and spleen was significantly reduced in CpG-treated animals as compared with non-treated mice. Reciprocally, lungs of CpG-treated infected animals were infiltrated with higher levels of neutrophils and inflammatory monocytes, as compared to control animals. Employing the B. mallei bioluminescent strain CSM001 and the Neutrophil-Specific Fluorescent Imaging Agent, bacterial dissemination and neutrophil trafficking were monitored in real-time using multimodal in vivo whole body imaging techniques. CpG-treatment increased recruitment of neutrophils to the lungs and reduced bioluminescent bacteria, correlating with decreased bacterial burden and increased protection against acute
Review question We looked for evidence of which antibiotics are best to treat a flare up of symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection.. Background Cystic fibrosis is a common inherited condition where the lungs often become blocked with mucus. This harms the lungs defences and often results in chronic, persistent infections that cannot be cleared by antibiotics. People with cystic fibrosis often need courses of antibiotics to reduce their symptoms (for instance cough, excess mucus and breathlessness) when these flare up or worsen. Such episodes are called exacerbations, and are usually treated with intravenous antibiotics (given through a drip into a vein). One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. They are ...
Nicholson, Audrey, Perry, John, James, Arthur, Stanforth, Stephen, Carnell, Sonya, Wilkinson, Kathryn, Khan, Anjam, de Soyza, Anthony and Gould, Kate (2012) In vitro activity of S-(3,4-dichlorobenzyl) isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents, 39 (1). pp. 27-32. ISSN 0924-8579 de Soyza, Anthony, Meachery, Gerard, Hester, Katy, Nicholson, Audrey, Parry, Gareth, Tocewicz, Krzysztof, Pillay, Thasee, Clark, Stephen, Lordan, James, Schueler, Stephan, Fisher, Andrew, Dark, John, Gould, Kate and Corris, Paul (2010) Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience. The Journal of Heart and Lung Transplantation, 29 (12). pp. 1395-1404. ISSN 1053 2498 Meachery, Gerard, de Soyza, Anthony, Nicholson, Audrey, Parry, Gareth, Hasan, Asif, Tocewicz, Krzysztof, ...
Review question. We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent.. Background. Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus blocks up their lungs and digestive systems. People with cystic fibrosis suffer from lots of chest infections, which cause scarring of their airways. Eventually, they develop infections that cant be cured with antibiotics, so their lungs always contain lots of bugs, this is described as being chronically infected. One of these bugs, Burkholderia cepacia, causes a lot of problems for people with cystic fibrosis because it is very difficult to treat and makes their lung disease deteriorate faster than it otherwise would. This is an updated version of the review.. Search date. We last searched for any evidence on 12 March 2019.. Study ...
Non-cystic fibrosis bronchiectasis Diagnosis. Non-cystic fibrosis bronchiectasis presents with a range of clinical manifestations from incidentally found bronchiectasis in asymptomatic individuals to massive hemoptysis and respiratory failure. With the widespread use of CT, clinicians increasingly encounter the incidental finding of bronchiectasis in asymptomatic patients who undergo chest or abdominal imaging for unrelated purposes. However, the most common clinical presentation is between these extremes. Non-cystic fibrosis bronchiectasis Treatment. It covers the details of conventional and current medical therapies available in the Non-cystic fibrosis bronchiectasis market for the treatment of the condition. It also provides the country-wise treatment guidelines and algorithm across the United States, Europe and Japan.. The DelveInsight Non-cystic fibrosis bronchiectasis market report gives a thorough understanding of Non-cystic fibrosis bronchiectasis by including details such as disease ...
Free Online Library: Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health, general Infection Health aspects
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TY - JOUR. T1 - Endemic Burkholderia cepacia bacteraemia. T2 - Clinical features and antimicrobial susceptibilities of isolates. AU - Yu, Wen Liang. AU - Wang, Der Yuan. AU - Lin, Cheng Wen. AU - Tsou, Mei Fen. PY - 1999. Y1 - 1999. N2 - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy ...
Although Staphylococcus epidermidis is responsible for the majority of cases after cataract surgery, any bacteria may cause postoperative endophthalmitis. Burkholderia cepacia (previously known as Pseudomonas cepacia) is a Gram negative, oxidase positive, non-fermentative bacilli. Burkholderia cepacia does cause significant infection not only in cystic fibrosis, chronic granulomatous disease, and immunocompromised patients, but also in healthy individuals.1 It has been shown to be resistant to some antiseptics such as benzalkonium chloride, clorhexidine at standard or high concentrations, and even be alive in those antiseptics.2. ...
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Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
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General Information: Burkholderia cenocepacia MC0-3 was isolated from soil associated with maize roots. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients. ...
To the Editor: In their review of the potential threat to human health by the commercial use of Burkholderia cepacia, Holmes et al. (1) focus on the biopesticidal uses of this bacterium in agriculture. By virtue of its ability to antagonize a number of soilborne plant pathogens, B. cepacia is an attractive natural alternative to currently used chemical pesticides, such as captan, mancozeb, and metalaxyl. The replacement of these highly toxic agents, which are among the mainstays of crop protection chemicals, by safer products is a laudable goal. However, despite being nonpathogenic to healthy humans (and thus classified as a Biosafety Level 1 species), B. cepacia can cause life-threatening pulmonary infection in persons with cystic fibrosis. Holmes et al. call for a moratorium on the use of B. cepacia in agriculture until more is known about risks from such use.. Perhaps of greater concern than agricultural use is B. cepacias use as a bioremedial agent. Holmes et al. only briefly refer to the ...
Quorum sensing is a mechanism for regulating proteobacterial gene expression in response to changes in cell population. In proteobacteria, N-acyl homoserine lactone (AHL) appears to be the most widely used signalling molecules in mediating, among others, the production of extracellular virulence factors for survival. In this work, the genome of B. cepacia strain GG4, a plasmid-free strain capable of AHL synthesis was explored. In silico analysis of the 6.6 Mb complete genome revealed the presence of a LuxI homologue which correspond to Type I quorum sensing. Here, we report the molecular cloning and characterization of this LuxI homologue, designated as BurI. This 609 bp gene was cloned and overexpressed in Escherichia coli BL21(DE3). The purified protein was approximately 25 kDa and is highly similar to several autoinducer proteins of the LuxI family among Burkholderia species. To verify the AHL synthesis activity of this protein, high resolution liquid chromatography-mass spectrometry analysis
Mapping transcription start sites across the B. cenocepacia genome added relevant information to the J2315 annotation. Genes and novel regulatory RNAs putatively involved in B. cenocepacia biofilm formation were identified. These findings will help in understanding regulation of B. cenocepacia biofi …
Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, wit...
A polyphasic taxonomic study including DNA-DNA reassociation experiments and an extensive biochemical characterization was performed on 14 Burkholderia isolates from moss gametophytes of nutrient-poor plant communities on the southern Baltic Sea coast in northern Germany. The strains were classified within two novel species, for which the names Burkholderia bryophila sp. nov. and Burkholderia megapolitana sp. nov. are proposed. The former species also includes isolates from grassland and agricultural soil collected in previous studies. Strains Burkholderia bryophila 1S18T (=LMG 23644T =CCUG 52993T) and Burkholderia megapolitana A3T (=LMG 23650T =CCUG 53006T) are the proposed type strains. They were isolated from Sphagnum rubellum and Aulacomnium palustre, respectively, growing in the Ribnitzer Großes Moor nature reserve (Mecklenburg-Pommern, Germany). All moss isolates of both novel species showed antifungal activity against phytopathogens as well as plant-growth-promoting properties.
The characteristic of most lipases is the interfacial activation at a lipid interface or in non-polar solvents. Interfacial activation is linked to a large conformational change of a lid, from a closed to an open conformation which makes the active site accessible for substrates. While for many lipases crystal structures of the closed and open conformation have been determined, the pathway of the conformational transition and possible bottlenecks are unknown. Therefore, molecular dynamics simulations of a closed homology model and an open crystal structure of Burkholderia cepacia lipase in water and toluene were performed to investigate the influence of solvents on structure, dynamics, and the conformational transition of the lid. The conformational transition of B. cepacia lipase was dependent on the solvent. In simulations of closed B. cepacia lipase in water no conformational transition was observed, while in three independent simulations of the closed lipase in toluene the lid gradually opened
General Information: This organism (AU 1054) was isolated from the blood of a patient with CF. This microbe has three chromosomes. Opportunistic pathogen. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients. ...
Cystic fibrosis center coordinated care - How can cystic fibrosis affect p.I.E.S development? Certainly. Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US. A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications. Emotional & phys. Development depend on severity, time in hospital, complications. Morb. & mort. Factors afect emotional, cognitive behavior.
Cook Childrens Cystic Fibrosis center is nationally accredited by the Cystic Fibrosis Foundation. Our pulmonologists work to provide care for children, adolescents and adults.
The Minnesota Cystic Fibrosis Center treats children, teens and adults with cystic fibrosis and other related lung and respiratory complications
The bacterium Burkholderia multivorans evolves and adapts in bursts to survive in the lungs of cystic fibrosis patients, according to a study published in...
SWISS-MODEL Repository entry for A0K968 (Y2294_BURCH), Probable transcriptional regulatory protein Bcen2424_2294. Burkholderia cenocepacia (strain HI2424)
SWISS-MODEL Repository entry for A0K923 (NUOA_BURCH), NADH-quinone oxidoreductase subunit A. Burkholderia cenocepacia (strain HI2424)
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Lineage: cellular organisms; Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex; Burkholderia ...
Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families. Antarctica is one of the most extraordinary places on Earth and exhibits many distinctive features. Antarctic microorganisms are well known producers of valuable secondary metabolites. Specifically, several Antarctic strains have been reported to inhibit opportunistic human pathogens strains belonging to Burkholderia cepacia complex (Bcc). Herein, we applied a biodiscovery pipeline for the identification of anti-Bcc compounds. Antarctic sub-sea sediments were collected from the Ross Sea, and used to isolate 25 microorganisms, which were phylogenetically affiliated to three bacterial genera (Psychrobacter, Arthrobacter, and Pseudomonas) via sequencing and analysis of 16S rRNA genes. They were then subjected to a primary cell-based screening to determine their bioactivity against Bcc strains. Positive isolates were used to produce crude extracts from microbial
Free Public Domain Picture: This photograph depicts the colonial morphology displayed by Gram-negative Burkholderia thailandensis bacteria, which was grown on a medium | ID: 13545336611235
Please Note: Ortholuge cannot be used for certain RBB analyses involving closely-related strains (e.g. Burkholderia cenocepacia J2315 versus Burkholderia cenocepacia AU 1054) because the phylogenetic distance between each ingroup protein is very small in relation to the phylogenetic distance between each ingroup protein and the associated outgroup protein. In these cases, the Ortholuge Classification value will be left blank which indicates Ortholuge analysis was not peformed, however the two proteins may very well be orthologs. In other cases, only some rows will be missing Ortholuge classifications, which can occur when a suitable gene could not be found in the outgroup species ...
Over 6 days in May 2013, 4 BCs out of 14 in the special care baby unit of Base Hospital Avissawella, grew B. cepacia. BCs became positive after a mean of 3.5 days since admission. All four neonates developed high levels of inflammatory markers and thrombocytopaenia. Organism showed identical ABs in all isolates, with sensitivity to meropenem, ceftazidime, ciprofloxacin and resistance to trimethoprim and aminoglycosides. All babies were successfully treated with meropenem.. A 10% dextrose solution used for the neonates grew B. Cepacia on culture. This solution is not readily available in our setting and its prepared in the unit, using 5% and 50% dextrose combination. It was used for different babies at multiple times throughout the day by several nurses. Other samples that grew B. cepacia included a bottle of normal saline used as a multiple dose vial for preparation of intravenous (IV) drugs, a gallipot of sterile water used for suction of airway of a ventilated baby, 2 incubator humidifiers ...
Burkholderia infection usually Burkholderia cepacia and other Burkholderia species Buruli ulcer Mycobacterium ulcerans ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
It is caused by infection with the bacterium Burkholderia mallei. Glanders is endemic in Africa, Asia, the Middle East, and ... Glanders is caused by infection with the Burkholderia mallei, usually by ingestion of contaminated feed or water.B. mallei is ... No vaccine is licensed for use in the U.S. Infection with these bacteria results in nonspecific symptoms and can be either ... Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is ...
Unlike Burkholderia species, Paraburkholderia members are not commonly associated with human infection. Paraburkholderia ... Additionally, the CSIs that were found to be shared by Burkholderia species are absent in Paraburkholderia, providing evidence ... Sawana A, Adeolu M, Gupta RS (2014). "Molecular signatures and phylogenomic analysis of the genus Burkholderia: proposal for ... which is what prompted their distinction as a genus independent from Burkholderia species, in combination with the finding of ...
"Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental ...
Chua KL, Chan YY, Gan YH (April 2003). "Flagella are virulence determinants of Burkholderia pseudomallei". Infection and ... The worm's ability to recognise a beneficial strain, as well as preferential host-specific infection by bacteria have been both ... Infection and Immunity. 72 (6): 3237-44. doi:10.1128/IAI.72.6.3237-3244.2004. PMC 415653. PMID 15155625. Jones ML (July 1981 ... but are acquired from the environment through the skin in a process akin to an infection. The digestive tract transiently ...
... biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic ... The flushing action of tears and saliva helps prevent infection of the eyes and mouth. Inflammation is one of the first ... In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that very few ... Walling off or discarding a part of a plant helps stop spread of an infection. Most plant immune responses involve systemic ...
In addition, opportunistic infection due to Burkholderia cepacia complex can occur, especially through transmission from ... Antibiotics by mouth such as ciprofloxacin or azithromycin are given to help prevent infection or to control ongoing infection ... which makes infection even more difficult to eradicate. The natural history of CF lung infections and airway remodeling is ... which can result in downstream mechanisms that progress the infection. In addition to typical bacterial infections, people with ...
During infection, some bacteria (e.g., Burkholderia pseudomallei) therefore produce superoxide dismutase to protect themselves ... "Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei". Microbiology. 157 ( ...
The recalled products said to contain Enterobacter gergoviae or Burkholderia cepecia, which at most causes infections if ...
... infection mechanisms of Burkholderia pseudomallei and melioidosis. Peacock has published around 150 papers on these topics. ... Towards the end of that year she was appointed Director of the National Infection Service, a department of Public Health ... on genomics highlights the potential for pathogen genomics in patient diagnosis and infection control". On Medicine. BioMed ... particularly on the bacterium Burkholderia pseudomallei and on methicillin-resistant Staphylococcus aureus (MRSA). She has held ...
"Identification of a siderophore receptor required for ferric ornibactin uptake in Burkholderia cepacia". Infection and Immunity ... "Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia (formerly ... Coenye T, Vandamme P, Govan JR, LiPuma JJ (October 2001). "Taxonomy and identification of the Burkholderia cepacia complex". ... LiPuma JJ (September 1998). "Burkholderia cepacia. Management issues and new insights". Clinics in Chest Medicine. 19 (3): 473- ...
Such biofilms are present in many successful infections, such as the chronic Pseudomonas aeruginosa and Burkholderia ... This is "adaptive" because it occurs during the lifetime of an individual as an adaptation to infection with that pathogen and ... Thus the immune response to infection may result in changes to the sleep cycle, including an increase in slow-wave sleep ... Long-term active memory is acquired following infection by activation of B and T cells. Active immunity can also be generated ...
Antibiotics used to treat Burkholderia pseudomallei infection (mellioidosis), for example β-lactams, fluoroquinolones and ... Kang Chen; Guang Wen Sun; Kim Lee Chua; Yunn-Hwen Gan (March 2005). "Modified Virulence of Antibiotic-Induced Burkholderia ... As an example of this, during urinary tract infection, filamentatious structures of uropathogenic E. coli (UPEC) start to ... "Filamentation by Escherichia coli subverts innate defenses during urinary tract infection". Proceedings of the National Academy ...
Re-infection is a recurrence of symptoms due to an infection with a new strain of Burkholderia pseudomallei following the ... This occurs when the infection (unless a new infection) has persisted in the blood at undetectable levels and then becomes ... In malaria, a recurrent infection can occur due to either recrudescence or relapse. Relapse means an infection is activated ... In melioidosis, a recurrent infection can be due to re-infection and relapse. ...
"Therefore, any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ...
Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with ... Infective endocarditis: An infection of the endocardium caused by enterococcus; used when the organism is not sensitive to ... At the end of World War II, the United States Army experimented with streptomycin to treat life-threatening infections at a ... Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell ...
Burkholderia pseudomallei infection) DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk *1602:DQA1* ... "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890-5 ... 0102:DQB1*0502 haplotype: graves disease, cervical cancer (human papilloma virus infection), scleroderma *1602:DQA1*05:DQB1* ...
... burkholderia infections MeSH C01.252.400.170.400 - glanders MeSH C01.252.400.170.531 - melioidosis MeSH C01.252.400.177 - ... bacteroides infections MeSH C01.252.400.126 - bartonellaceae infections MeSH C01.252.400.126.100 - bartonella infections MeSH ... moraxellaceae infections MeSH C01.252.400.560.022 - acinetobacter infections MeSH C01.252.400.610 - mycoplasmatales infections ... salmonella infections, animal MeSH C01.252.400.310.821.873 - typhoid fever MeSH C01.252.400.310.850 - serratia infections MeSH ...
... à une infection à Burkholderia cepacia complex chez un nourrisson révélant une granulomatose septique et une intégration ... Primary infections in adults are rare since most occurrences are in children. When the infection does occur for the first time ... Once inside, two outcomes have been described: active and inactive infections. Active infections involve the linear dsDNA ... Lymphohistiocytic activation syndrome and Burkholderia cepacia complex infection in a child revealing chronic granulomatous ...
... or splenous infections. B. mallei infection has a fatality rate of 95% if left untreated, and a 50% fatality rate in ... Burkholderia mallei is a Gram-negative, bipolar, aerobic bacterium, a human and animal pathogen of genus Burkholderia causing ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ...
B. pseudomallei infection in humans is called melioidosis; its mortality is 20 to 50% even with treatment. The antibiotic of ... October 2005). "Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for ... 2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450.. ...
... in humans is an opportunistic pathogen that is an important agent for hospital-associated infections. It ... PubMed article on PCR identification of Burkholderia EMedicine overview of Burkholderia Type strain of Burkholderia gladioli at ... Burkholderia gladioli is closely related to, and often mistaken for, a member of the Burkholderia cepacia complex. This ... Burkholderia gladioli can be distinguished from the other Burkholderia because it is oxidase negative B. gladioli is indole ...
"Burkholderia contaminans: Unusual cause of biliary sepsis". Journal of Infection and Chemotherapy. 19 (5): 969-71. doi:10.1007/ ... Burkholderia contaminans is a gram-negative, bacterium from the genus of Burkholderia and the family of Burkholderiaceae and ... Burkholderia acidipaludis can cause biliary sepsis. "Genus Burkholderia". List of Prokaryotic Names with Standing in ... Type strain of Burkholderia contaminans at BacDive - the Bacterial Diversity Metadatabase v t e. ...
"Arabinose-positive Burkholderia pseudomallei infection in humans: case report". Clin Infect Dis. 28 (4): 927-28. doi:10.1086/ ... Brett PJ, DeShazer D, Woods DE (1998). "Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species". Int J ... "Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection". Microb Pathog. 48 (1): 9- ... Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. It is closely ...
A review of B. cenocepacia in respiratory infections of cystic fibrosis patients stated that "one of the most threatening ... "Burkholderia cenocepacia". NCBI Taxonomy Browser. 95486. Type strain of Burkholderia cenocepacia at BacDive - the Bacterial ... Burkholderia cenocepacia is a species of Gram-negative bacteria that is common in the environment, can form a biofilm with ... See also: Burkholderia thailandensis sRNA Originally defined as B. cepacia, the group has now been split into nine species, and ...
Frost, F; Shaw, M; Nazareth, D (June 13, 2019). "Antibiotic therapy for chronic infection with Burkholderia cepacia complex in ... Burkholderia cepacia complex in the NCBI Taxonomy Browser Type strain of Burkholderia cepacia complex at BacDive, the Bacterial ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ... "Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence". ...
Their infection of rice panicles occurs at flowering, if the bacterial population reaches a threshold level and environmental ... Burkholderia glumae is a Gram-negative soil bacterium. Symptoms of bacterial panicle blight include seedling blighting and ... Newsletter.pdf Type strain of Burkholderia glumae at BacDive - the Bacterial Diversity Metadatabase. ...
... and Burkholderia cepacia, an important pathogen of pulmonary infections in people with cystic fibrosis (CF). The Burkholderia ( ... Burkholderia alpina Burkholderia ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia ... Burkholderia dolosa Burkholderia gladioli Burkholderia glumae Burkholderia humptydooensis Burkholderia lata Burkholderia latens ... Burkholderia mallei Burkholderia metallica Burkholderia multivorans Burkholderia oklahomensis Burkholderia plantarii ...
... და ზოგჯერ Burkholderia cepacia). 18 წლის ასაკისთვის პაციენტების 80% P. aeruginosa-ს სამიზნე ხდება, ხოლო 3.5%-ში B. cepacia-სი.[ ... Høiby N (June 1995). "Isolation and treatment of cystic fibrosis patients with lung infections caused by Pseudomonas ( ... Burkholderia) cepacia and multiresistant Pseudomonas aeruginosa". Neth J Med 46 (6): 280-87. . PMID 7643943. ... "The environmental risk factors associated with medical and dental equipment in the transmission of Burkholderia (Pseudomonas) ...
Unidentified infection of the pigs amplified the force of infection, eventually transmitting the virus to farmers and causing ... Burkholderia mallei. horses, donkeys direct contact Gnathostomiasis Gnathostoma spp. dogs, minks, opossums, cats, lions, tigers ... Close contact with cattle can lead to cutaneous anthrax infection, whereas inhalation anthrax infection is more common for ... Taenia crassiceps infection Taenia crassiceps wolves, coyotes, jackals, foxes contact with soil contaminated with feces ...
Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[12] ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract.[1] When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ...
... inflammation and bacterial infection in the respiratory tract. Lactoferrin with hypothiocyanite has been granted orphan drug ... Burkholderia cepacia • Campylobacter jejuni • Capnocytophaga ochracea • Corynebacterium xerosis • Enterobacter cloacae • ... "Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice". J. Med. Microbiol ... weakened respiratory immune system against bacterial infection. Symptoms of cystic fibrosis include an inability to secrete ...
... of people with gonorrheal infection also have chlamydial infection.[54] Infections of the throat can be especially problematic ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... Both men and women with infections of the throat may experience a sore throat, though such infection does not produce symptoms ... The infection is usually spread from one person to another through vaginal, oral, or anal sex.[15][22] Men have a 20% risk of ...
... is an infection of the small intestine by some strains of the bacterium Vibrio cholerae.[4][3] Symptoms may range from ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... "The Journal of Infection. 66 (5): 432-8. doi:10.1016/j.jinf.2012.11.013. PMC 3677557. PMID 23201968.. ... Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The ...
If the infection is severe, the doctor may prescribe antibiotics, such as ciprofloxacin or TMP-SMX (Bactrim). Unfortunately, ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... In addition, chronic arthritis secondary to S. flexneri infection, called reactive arthritis, may be caused by a bacterial ... Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary ...
Unidentified infection of the pigs amplified the force of infection, eventually transmitting the virus to farmers and causing ... Burkholderia mallei.. horses, donkeys. direct contact. Hantavirus. Hantavirus spp.. deer mice, cotton rats and other rodents. ... Close contact with cattle can lead to cutaneous anthrax infection, whereas inhalation anthrax infection is more common for ... Toxocariasis is infection of humans of any of species of roundworm, including species specific to the dog (Toxocara canis) or ...
Burkholderia pseudomallei (Melioidosis) · Burkholderia mallei (Glanders) · Burkholderia cepacia complex · Bordetella pertussis/ ... Rickettsia aeschlimannii infection) ...
Burkholderia gladioli (sin. Pseudomonas cocovenenans), menghasilkan asam bongkrek, terdapat pada tempe bongkrek[51] ... The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by ... Acetobacter (gram -) Borrelia (gram -) Bortadella (gram -) Burkholderia (gram -) Campylobacter (gram -) Chlamydia (gram -) ...
... (TD) is a stomach and intestinal infection. TD is defined as the passage of unformed stool (one or more by ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... The primary source of infection is ingestion of fecally contaminated food or water. Attack rates are similar for men and women. ... Antibiotics can also cause vaginal yeast infections, or overgrowth of the bacterium Clostridium difficile, leading to ...
... since it is the second-most common infection in hospitalized patients (nosocomial infections)[citation needed]. This ... And transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia ... Main article: Pseudomonas infection. Infectious species include P. aeruginosa, P. oryzihabitans, and P. plecoglossicida. P. ... Lau GW; Hassett DJ; Ran H; Kong F (2004). "The role of pyocyanin in Pseudomonas aeruginosa infection". Trends in Molecular ...
Salih, Barik (June 2007). "H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... 2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal lesions in C57BL/6 mice". Scand ... "Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice". J. Antimicrob. Chemother. 51 (2): 367-71 ...
Boyton R, Openshaw P. "Pulmonary defences to acute respiratory infection". Br Med Bull. 61: 1-12. PMID 11997295.. ... Biofilm dapat ditemui pada banyak infeksi, seperti infeksi Pseudomonas aeruginosa kronis dan Burkholderia cenocepacia, yang ... Kawai T, Akira S (2006). "Innate immune recognition of viral infection". Nat Immunol. 7 (2): 131-7. PMID 16424890.. ... Harty J, Tvinnereim A, White D. "CD8+ T cell effector mechanisms in resistance to infection". Annu Rev Immunol. 18: 275-308. ...
Infections à méningocoques Maladies infectieuses et Africa. West Africa. Med. Bull. 2007[unreliable source?] ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a ... Meningococcal infection is usually introduced into a household by an asymptomatic person. Carriage then spreads through the ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... This infection-related cutaneous condition article is a stub. You can help Wikipedia by expanding it.. *v ... Chromobacteriosis infections are a cutaneous condition caused by chromobacteria characterized by fluctuating abscesses.[1]:279 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Chromobacteriosis_infection&oldid=910443079" ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Confirmation of infection can be done by examining serum taken during the early and late stages of infection. To quickly screen ... Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ... The three types of plague are the result of the route of infection: bubonic plague, septicemic plague, and pneumonic plague.[1] ... 14] With no new rat inputs being added to the population from other areas, the infection would only spread to humans in very ...
Other members of the class can infect plants, such as Burkholderia cepacia which causes bulb rot in onions as well as ...
... of infection together with systemic manifestations of infection".[4] These manifestations may include:. *Tachypnea (fast rate ... Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia ... The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. It may be located in ... Documented evidence of infection, may include positive blood culture, signs of pneumonia on chest x-ray, or other radiologic or ...
... skin infections, typhoid fever, and urinary tract infections, among others.[2] For some infections it is used in addition to ... some Burkholderia cepacia, Clostridium innocuum and Enterococcus faecium strains have developed resistance to ciprofloxacin to ... Ciprofloxacin is an antibiotic used to treat a number of bacterial infections.[2] This includes bone and joint infections, ... Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses ...
Common pathogenic infection methodsEdit. *Cell wall-degrading enzymes: These are used to break down the plant cell wall in ... Burkholderia[8]. *Proteobacteria *Xanthomonas spp.. *Pseudomonas spp.. *Pseudomonas syringae pv. tomato causes tomato plants to ... Creamer, Rebecca; H. Hubble; A. Lewis (May 2005). "Curtovirus Infection of Chile Pepper in New Mexico". Plant Diseases. 89 (5 ... Oomycetes are capable of using effector proteins to turn off a plant's defenses in its infection process.[6] Plant pathologists ...
Lau GW, Hassett DJ, Ran H, Kong F (2004). "The role of pyocyanin in Pseudomonas aeruginosa infection". Trends in molecular ... And transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia ... Yabuuchi, E.; Kosako, Y.; Yano, I.; Hotta, H.; Nishiuchi, Y. (1995). "Transfer of two Burkholderia and an Alcaligenes species ... Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model. Antimicrob Agents Chemother. 2007 June; 51(6): ...
Fresh-water bacterial infections include Aeromonas hydrophila, Burkholderia pseudomallei causing melioidosis, leptospira ... Other salt-water Mycobacterium infections include the slow growing M. marinum and fast growing M. fortuitum, M. chelonae, and M ... Flood-associated skin infections: Flood waters are often contaminated with bacteria and waste as well as chemicals on occasion ... These infections are exacerbated with a compromised immune system or an aging population.[6] The most common bacterial skin ...
Multistate Outbreak of Burkholderia cepacia Infections Associated with Contaminated Ultrasound Gel ... infections in healthcare facilities. Patients have developed Bcc infections, including bloodstream infections, after likely ... Types of Infectionsplus icon *Central Line-associated Bloodstream Infectionsplus icon *Resources for Patients & Providers ... As of August 18, 2021, CDC is aware of at least 59 patients in 6 states with Burkholderia stabilis infection with a bacterial ...
... and numerous healthcare facilities to investigate a multi-state outbreak of Burkholderia cepacia infections. These infections ... Types of Infectionsplus icon *Central Line-associated Bloodstream Infectionsplus icon *Resources for Patients & Providers ... Facilities that identify infections caused by B. cepacia complex among non-CF patients or clusters of these infections among CF ... cepacia complex infections among patients with CF should be reported when infection rates appear above endemic rates. Cases ...
Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections. Charles C. Traverse ... Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection ... Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic ... Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections ...
Our results indicate that protection of CpG-treated animals was associated with recruitment of neutrophils prior to infection ... Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective ... methods to monitor disease progression and to evaluate the efficacy of therapeutic treatment during bacterial infections. ... Keywords: Burkholderia mallei; CpG; immunomodulation; in vivo imaging; infrared fluorescent imaging Burkholderia mallei; CpG; ...
Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health ... Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. ... MLA style: "Environmental Burkholderia cepacia complex isolates in human infections.." The Free Library. 2007 U.S. National ... APA style: Environmental Burkholderia cepacia complex isolates in human infections.. (n.d.) >The Free Library. (2014). ...
Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by ... New insights into Burkholderia pseudomallei infection (melioidosis). International Congress on Bacteriology & Infectious ... with a special interest Burkholderia pseudomallei and Salmonella typhi infection and the role of diabetes as well as the gut ... Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by ...
Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic ... Iatrogenic postoperative spondylodiscitis attributed to Burkholderia cepacia infection in an immunocompetent patient. *. ... Of onions and men: Report of cavitary community acquired pneumonia due to Burkholderia cepacia complex in an immunocompetent ... Genome sequence-based curation of PubMLST data challenges interspecies recombination in the Burkholderia cepacia complex ...
Burkholderia infection is caused by the Burkholderia cepacia bacteria. B. cepacia is an aerobic gram-negative bacillus native ... Known side effects of Burkholderia infection. The known side effects of Burkholderia infection are similar to the symptoms ... Burkholderia infection is caused by the Burkholderia cepacia bacteria. B. cepacia is an aerobic gram-negative bacillus native ... Zinc can help fight off infections.. Treatments, management plans for Burkholderia infection. B. cepacia can be resistant to a ...
Burkholderia malleli is able to cause two forms of human infection. Farcy is a subcutaneous form of the bacterial infection ... Best Approach to Infection and Tumor Treatment: Contain or Eliminate?. *Study Identifies Factors Associated With Infection- ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ...
... Summary This latest Pharmaceutical and Healthcare ... provides an overview of the Burkholderia pseudomallei Infections (Infectious Disease) pipeline landscape.. Burkholderia ... The Burkholderia pseudomallei Infections (Infectious Disease) pipeline guide also reviews of key players involved in ... Burkholderia pseudomallei Infections (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in ...
Multilocus variable number tandem repeat analysis of a Burkholderia mallei strain isolated from a diseased dromedary in Bahrain ... We confirm a natural infection of dromedaries with glanders. ... Natural Burkholderia mallei Infection in Dromedary, Bahrain On ... infection (12,13). However, reports of B. mallei infection in dromedaries have described artificial infections (4,5). We report ... Natural Burkholderia mallei Infection in Dromedary, Bahrain. Emerging Infectious Diseases. 2011;17(7):1277-1279. doi:10.3201/ ...
We describe a case of B. thailandensis infection in a person in China, a location heretofore unknown for B. thailandensis. We ... Burkholderia thailandensis infection in humans is uncommon. We describe a case of B. thailandensis infection in a person in ... Arabinose-positive Burkholderia pseudomallei infection in humans: case report. Clin Infect Dis. 1999;28:927-8. DOIPubMed ... Human Infection with Burkholderia thailandensis, China, 2013. Emerging Infectious Diseases. 2017;23(8):1416-1418. doi:10.3201/ ...
... sales value of Drugs for Burkholderia Pseudomallei InfectionsThis report studies Drugs for Burkholderia Pseudomallei Infections ... means the output of Drugs for Burkholderia Pseudomallei InfectionsRevenue, means the ... 10 Drugs for Burkholderia Pseudomallei Infections Marketing Type Analysis. 10.1 Drugs for Burkholderia Pseudomallei Infections ... 9.2 Drugs for Burkholderia Pseudomallei Infections Regional Market Trend. 9.2.1 North America 2016-2021 Drugs for Burkholderia ...
We have recently isolated Burkholderia pseudomallei from an Eritrean patient in Israel. The isolate was assigned a novel ... f A Burkholderia pseudomallei Infection Imported from Eritrea to Israel * Yaniv Almog1, Yael Yagel2, Yuval Geffen3, Pablo ... Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nature Microbiol 1: 1-5.[Crossref] ... We have recently isolated Burkholderia pseudomallei from an Eritrean patient in Israel. The isolate was assigned a novel ...
Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis. Review question ... This review highlights an urgent need for more research into new ways of treating long-term Burkholderia cepacia infection in ... Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with ... We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with ...
Chronic infection with Burkholderia spp. defined by:. *One sputum (or bronchoalveolar lavage) culture positive for Burkholderia ... Infection. Communicable Diseases. Fibrosis. Cystic Fibrosis. Burkholderia Infections. Pathologic Processes. Pancreatic Diseases ... Gram-Negative Bacterial Infections. Bacterial Infections. Aztreonam. Anti-Bacterial Agents. Anti-Infective Agents. ... in Patients With Cystic Fibrosis and Chronic Burkholderia Species Infection. This study has been completed. ...
Three German patients developed nosocomial pneumonia after cardiac surgery and had Burkholderia cepacia complex detected in ... Outbreak of Burkholderia cepacia bloodstream infections traced to the use of Ringer lactate solution as multiple-dose vial for ... An outbreak of Burkholderia cepacia complex infections associated with contaminated liquid docusate. Infect Control Hosp ... Outbreak of Burkholderia cepacia complex infections associated with contaminated octenidine mouthwash solution, Germany, August ...
... patients infected with Burkholderia cepacia. As a significant proportion of patients with CF in our community are infected with ... Infection with Burkholderia cepacia in cystic fibrosis: outcome following lung transplantation Am J Respir Crit Care Med. 2001 ... patients infected with Burkholderia cepacia. As a significant proportion of patients with CF in our community are infected with ...
Within-Host Evolution of Burkholderia pseudomallei over a Twelve-Year Chronic Carriage Infection. Erin P. Price, Derek S. ... Burkholderia pseudomallei is considered a highly pathogenic bacterium because infection is commonly fatal. Here, we document ... Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model ... Variations in ceftazidime and amoxicillin-clavulanate susceptibilities within a clonal infection of Burkholderia pseudomallei. ...
Whilst control mice succumbed to the infection by day 9, smBpF4-immunized mice were protected against the lethal challenge and ... Whilst control mice succumbed to the infection by day 9, smBpF4-immunized mice were protected against the lethal challenge and ... Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst ... Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst ...
1996) Epidemiology of Burkholderia cepacia infection in patients with cystic fibrosis: analysis by randomly amplified ... 1995) Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia ( ... Siderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia Patricia Darling, Maria Chan, Andrew D. Cox, Pamela ... Siderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia Patricia Darling, Maria Chan, Andrew D. Cox, Pamela ...
To investigate an outbreak of Burkholderia (formerly (Pseudomonas) cepacia respiratory tract colonization and infection in ... An Outbreak of Burkholderia (Formerly Pseudomonas) cepacia Respiratory Tract Colonization and Infection Associated with ... An Outbreak of Burkholderia (Formerly Pseudomonas) cepacia Respiratory Tract Colonization and Infection Associated with ... 42 patients had B. cepacia respiratory tract colonization or infection. Observation of intensive care unit and respiratory care ...
Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Burkholderia humptydooensis sp. nov., a new species related to Burkholderia thailandensis and the fifth member of the ...
Burkholderia Infections Market report categorizes the global market by drug type, distribution channel, and geography - Global ... Burkholderia infections also cause complications such as soft tissue infections, urinary tract infection and surgical wound ... Burkholderia infections are caused by Burkholderia cepacia. It is a gram negative bacillus found in aquatic environment. It is ... Burkholderia infection symptom can vary widely in people, ranging from no symptoms to serious respiratory infection. Based on ...
Burkholderia cepacia complex infection in patients with cystic fibrosis. J. Med. Microbiol.51:533-538. ... Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of ... The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections. Microbiology ... Using a rat chronic respiratory infection model, Sokol et al. (46) demonstrated that infections with cepIR mutants caused ...
Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram- ... These infections may be associated with a fulminant necrotising pneumonia. Burkholderia cepacia complex bacteria are resistant ... Burkholderia cepacia complex infections present a significant challenge for people with cystic fibrosis and their clinicians. ... Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis ...
Burkholderia malleli is able to cause two forms of human infection. Farcy is a subcutaneous form of the bacterial infection ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
... of Protein-Specific Monoclonal Antibody-Based Latex Agglutination for Rapid Diagnosis of Burkholderia pseudomallei Infection in ... of Protein-Specific Monoclonal Antibody-Based Latex Agglutination for Rapid Diagnosis of Burkholderia pseudomallei Infection in ... of Protein-Specific Monoclonal Antibody-Based Latex Agglutination for Rapid Diagnosis of Burkholderia pseudomallei Infection in ... of Protein-Specific Monoclonal Antibody-Based Latex Agglutination for Rapid Diagnosis of Burkholderia pseudomallei Infection in ...
Human Infection with Burkholderia thailandensis, China, 2013 Dance DAB., Sarovich D., Price EP., Limmathurotsakul D., Currie BJ ... Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis * Community engagement for the ... Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei ... Geographical distribution of Burkholderia pseudomallei in soil in Myanmar * Why do people purchase antibiotics over-the-counter ...
  • Abstract Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram-negative bacteria and the causative agents of melioidosis and glanders, respectively. (sbir.gov)
  • The Burkholderia pseudomallei Infections (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Burkholderia pseudomallei Infections (Melioidosis) and features dormant and discontinued projects. (reportbuyer.com)
  • Burkholderia thailandensis is closely related to B. pseudomallei , the causative agent of melioidosis ( 1 ). (cdc.gov)
  • Burkholderia pseudomallei causes the potentially fatal disease melioidosis. (asm.org)
  • Human melioidosis presents with an array of clinical symptoms ranging from acute or chronic localized infection involving a single organ, to fulminant septicaemia in multiple organs and septic shock ( Cheng and Currie, 2005 ). (frontiersin.org)
  • Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as melioidosis. (health.mil)
  • Historically, melioidosis was a common infection in military forces serving in Southeast Asia, and it has the potential to have a serious impact on force health readiness. (health.mil)
  • Melioidosis is a potentially lifethreatening disease caused by the gram-negative bacterium Burkholderia pseudomallei . (health.mil)
  • Burkholderia pseudomallei is a Gram-negative facultative intracellular bacterium and the causative agent of melioidosis, a severe infectious disease found throughout the tropics. (asm.org)
  • Due to the high case fatality rate, intrinsic resistance to multiple antibiotic treatments, susceptibility to infection via the aerosol route, and potential use as a bioweapon, we have developed an effective live attenuated PBK001 vaccine capable of protecting against aerosolized melioidosis. (asm.org)
  • Melioidosis-associated peri-prosthetic infection is extremely rare. (biomedcentral.com)
  • Melioidosis should be entertained in the differential diagnosis of peri-prosthetic infections in high risk patients. (biomedcentral.com)
  • To date, melioidosis associated infection of the ankle joint following an internal fixation has not been reported. (biomedcentral.com)
  • We describe a man with long standing history of diabetes who developed melioidosis associated peri-prosthetic infection over the ankle joint. (biomedcentral.com)
  • Distributed via the CDC Health Alert Network June 30, 2021, 2:30 PM ET CDCHAN-00444 The Kansas Department of Health and Environment, the Texas Department of State Health Services, and the Minnesota Department of Health, with assistance from the Centers for Disease Control and Prevention (CDC), are investigating three cases of Burkholderia pseudomallei (melioidosis) infections. (cdc.gov)
  • Burkholderia pseudomallei is the causative agent of melioidosis, which is considered a potential deliberate release agent. (ox.ac.uk)
  • Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei , whose portals of entry into the body include subcutaneous, ingestion and inhalation routes. (microbiologyresearch.org)
  • Route of infection in melioidosis. (microbiologyresearch.org)
  • One example is melioidosis, a disease caused by infection with Burkholderia pseudomallei, which is of public health importance in Southeast Asia and Northern Australia, with an expanding global distribution. (nih.gov)
  • Although binge alcohol consumption has been considered as a risk factor for the development of melioidosis, no experimental studies have investigated the outcomes of alcohol exposure on Burkholderia spp. (nih.gov)
  • We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. (cdc.gov)
  • Melioidosis or infection with Burkholderia pseudomallei presents with protean manifestations. (biomedcentral.com)
  • Melioidosis is a systemic infection caused by non fermenting gram negative bacilli Burkholderia pseudomallei . (biomedcentral.com)
  • The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. (ox.ac.uk)
  • In this study, we aimed to analyze the gene expression levels of important cytokines in melioidosis patients and establish useful correlates with disease biomarkers compared to cases of sepsis infection caused by other pathogens and healthy individuals. (asm.org)
  • We analyzed 26 melioidosis cases, 5 healthy controls, and 10 cases of sepsis infection caused by other pathogens. (asm.org)
  • Burkholderia pseudomallei is the causative agent of melioidosis. (edu.au)
  • CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia pseudomallei, the causative agent of melioidosis. (edu.au)
  • Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Gram-negative facultative intracellular pathogens, which are the causative agents of melioidosis and glanders, respectively. (biomedcentral.com)
  • DoH Digital Library: Whole-genome sequencing of Burkholderia pseudomallei isolates from an unusual melioidosis case identifies a polyclonal infection with the same multilocus sequence type. (nt.gov.au)
  • Twelve Burkholderia pseudomallei isolates collected over a 32-month period from a patient with chronic melioidosis demonstrated identical multilocus sequence types (STs). (nt.gov.au)
  • DoH Digital Library: Osteomyelitis and septic arthritis from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study from northern Australia. (nt.gov.au)
  • The gram-negative organism, Burkholderia pseudomallei, is responsible for the disease melioidosis. (nt.gov.au)
  • The Kansas Department of Health and Environment, the Texas Department of State Health Services, and the Minnesota Department of Health, with assistance from the Centers for Disease Control and Prevention (CDC), are investigating three cases of Burkholderia pseudomallei (melioidosis) infections. (cdc.gov)
  • Symptoms of melioidosis are varied and nonspecific and may include pneumonia, abscess formation, and/or blood infections. (cdc.gov)
  • Burkholderia pseudomallei , the causative agent of melioidosis, is a Tier 1 select agent external icon which can affect both animals and humans. (cdc.gov)
  • Melioidosis symptoms are nonspecific and vary depending on the type of infection. (cdc.gov)
  • Melioidosis is caused by an infection with Burkholderia pseudomallei. (unboundmedicine.com)
  • Focusing on a pathogen of the cystic fibrosis lung, Burkholderia cenocepacia, we sequenced clones and metagenomes to unravel the mutations and evolutionary forces responsible for adaptation and diversification of a single biofilm community during 1,050 generations of selection. (pnas.org)
  • In this environment, we studied adaptation by a soil isolate of Burkholderia cenocepacia , an opportunistic pathogen responsible for fatal biofilm-associated lung infections in CF patients ( 14 , 15 ). (pnas.org)
  • Effects of extended storage of chlorhexidine gluconate and benzalkonium chloride solutions on the viability of Burkholderia cenocepacia. (eurosurveillance.org)
  • Several transmissible Burkholderia cenocepacia strains that infect multiple cystic fibrosis patients contain a genomic island designated as the c eno c epacia i sland (cci). (asm.org)
  • High levels of AGS3 in macrophages enhanced their resistance to infection by Burkholderia cenocepacia J2315, Mycobacterium tuberculosis , and methicillin-resistant Staphylococcus aureus , whereas AGS3-deficient macrophages were more susceptible. (jimmunol.org)
  • Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a" by Akshu Balwan, David P Nicolau et al. (mainehealth.org)
  • Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient. (mainehealth.org)
  • Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003.017210). (mainehealth.org)
  • B. cenocepacia often possesses innate resistance to multiple antimicrobial classes, making eradication uncommon in established infection (P. B. Davis, Am J Respir Crit Care Med 173:475-482, 2006, http://dx.doi.org/10.1164/rccm.200505-840OE). (mainehealth.org)
  • We report the use of clinafloxacin in a CF patient with advanced B. cenocepacia infection, present pharmacokinetic (PK) data, and discuss the potential therapeutic role of clinafloxacin in patients with this condition. (mainehealth.org)
  • Here, we present a genome-wide view of the molecular mutation spectrum in Burkholderia cenocepacia , a clinically relevant pathogen with high %GC content and multiple chromosomes. (genetics.org)
  • Burkholderia cenocepacia is an opportunistic pathogen associated with chronic lung infections and increased risk of death in patients with cystic fibrosis (CF). In this work, we investigated the lipopolysaccharide (LPS) of clinical variants of B. cenocepacia that were collected from a CF patient over a period of 3.5 years, from the onset of infection until death by necrotizing pneumonia (cepacia syndrome). (frontiersin.org)
  • This study provides support to the notion that OAg LPS modifications are an important factor in the adaptation of B. cenocepacia to chronic infection and that the heterogeneity of OAgs relates to variation within the OAg gene cluster, indicating that the gene cluster might have been assembled through multiple horizontal transmission events. (frontiersin.org)
  • Cable pili are peritrichous organelles expressed by certain strains of Burkholderia cenocepacia , believed to facilitate colonization of the lower respiratory tract in cystic fibrosis patients. (asm.org)
  • While Bcc strains belonging to all nine genomovars have been isolated from CF patients, genomovar III strains, recently reclassified as B. cenocepacia , are most commonly associated with respiratory infections in CF worldwide ( 43 ). (asm.org)
  • Burkholderia cepacia genomovars I and VI, Burkholderia multivorans (genomovar II), Burkholderia cenocepacia (genomovar III), Burkholderia stabilis (genomovar IV), Burkholderia vietnamiensis (genomovar V), Burkholderia ambifaria (genomovar VII), Burkholderia anthina (genomovar VIII), and Burkholderia pyrrocinia (genomovar IX) ( 2 , 9 , 10 ). (asm.org)
  • Agnoli K, Lowe CA, Farmer KL, Husnain SI, Thomas MS (2006) The ornibactin biosynthesis and transport genes of Burkholderia cenocepacia are regulated by an extracytoplasmic function s factor which is a part of the Fur regulon. (springer.com)
  • Bernier SP, Sokol PA (2005) Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia . (springer.com)
  • Bernier SP, Nguyen DT, Sokol PA (2008) A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence. (springer.com)
  • Bylund J, Burgess LA, Cescutti P, Ernst RK, Speert D (2006) Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species. (springer.com)
  • Additional laboratory testing of isolates or specimens from patients with reported Bcc infections and of additional lots of MediChoice® M500812 ultrasound gel is currently underway. (cdc.gov)
  • These mutations in turn were surprisingly well represented among mutations that evolved in cystic fibrosis isolates of both Burkholderia and Pseudomonas . (pnas.org)
  • Because isolates recovered from chronic infections of different patients often resemble these biofilm-specific variants ( 7 ⇓ - 9 ), they may reflect adaptation to similar selective forces in vivo. (pnas.org)
  • Environmental Burkholderia cepacia complex isolates in human infections. (thefreelibrary.com)
  • To evaluate how widespread the emergence of environmental isolates as causes of clinical infections may be, we used a highly discriminatory and transportable typing method to study isolates from several large bacterial culture collections. (thefreelibrary.com)
  • Finally, we identified a frameshift mutation in both P314 isolates within wcbR , an important component of the capsular polysaccharide I locus, suggesting virulence attenuation early in infection. (asm.org)
  • Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. (asm.org)
  • We have shown that pyochelin and SA are commonly produced by B. cepacia respiratory isolates from CF patients ( 18 , 19 ) and that they may play a role as virulence factors in these infections. (asm.org)
  • No further isolates of B. cepacia were identified after institution of appropriate infection control procedures. (annals.org)
  • Here we studied two Burkholderia multivorans clonal isolates displaying different morphotypes from a chronically infected CF patient to evaluate trait development during lung infection. (microbiologyresearch.org)
  • Here we combined current genome sequencing technologies and detailed phenotypic profiling of the opportunistic pathogen Burkholderia multivorans using sequential isolates sampled from a CF patient over 20 years. (asm.org)
  • Misidentification of Burkholderia cepacia in US cystic fibrosis treatment centers: an analysis of 1,051 recent sputum isolates. (semanticscholar.org)
  • Burkholderia cepacia isolates were sensitive to piperacillin - tazobactam and sulfamethoxazole - trimethoprim , and resistant to amikacin and colistin . (bvsalud.org)
  • Later DNA amplification and sequencing of the bacterial 16S rDNA identified the isolates previously identified as P. fluorescens and B. melitensis as Mesorhizobium amorphae and Burkholderia fungorum (isolate BF370), respectively. (cdc.gov)
  • This paper reports on how these patients perceive and manage the risk of cepacia infection using Douglas and Calvez's (1990) typology of four cultures of the community (the central community, dissenting enclaves, isolates, and individualists) and Douglas' works on pollution, risk, and culture. (sussex.ac.uk)
  • The central community of adults was found to be dispersing to form a series of isolates, perceiving others who may potentially have infection as individualists. (sussex.ac.uk)
  • These isolates were from clinical and environmental sources and included 107 B. cepacia complex strains, 23 Burkholderia gladioli strains, 20 Ralstonia pickettii strains, 10 Pseudomonas aeruginosa strains, 8 Stenotrophomonas maltophilia strains, and 9 isolates belonging to nine other species. (asm.org)
  • Chronic infection with opportunistic pathogens including Burkholderia cepacia complex (Bcc) is a hallmark of cystic fibrosis (CF). We investigated the adaptive mechanisms facilitating chronic lung infection in sequential Bcc isolates from two siblings with CF (P1 and P2), one of whom also experienced intermittent blood-stream infections (P2). (maynoothuniversity.ie)
  • Burkholderia (formerly Pseudomonas ) cepacia is an opportunistic pathogen in immunocompromised patients, particularly those with cystic fibrosis (CF) or chronic granulomatous disease (reviewed in references 8 and 9 ). (asm.org)
  • To investigate an outbreak of Burkholderia (formerly ( Pseudomonas ) cepacia respiratory tract colonization and infection in mechanically ventilated patients. (annals.org)
  • Although evidence-based guidelines exist for treating respiratory exacerbations involving Pseudomonas aeruginosa, these cannot be extended to Burkholderia cepacia complex infections. (cochrane.org)
  • Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo. (nih.gov)
  • Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection. (nih.gov)
  • Antibiotic susceptibility testing in early and chronic respiratory infections with Pseudomonas aeruginosa. (nih.gov)
  • and Pseudomonas aeruginosa (an organism that causes 10 percent of all hospital-acquired infections in the United States). (newswise.com)
  • Burkholderia pseudomallei (also known as Pseudomonas pseudomallei) is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium. (wikipedia.org)
  • Even when the isolate is recognised to be significant, commonly used identification systems may misidentify the organism as Chromobacterium violaceum or other nonfermenting, Gram-negative bacilli such as Burkholderia cepacia or Pseudomonas aeruginosa. (wikipedia.org)
  • Burns JL, Jonas M, Chi EY, Clark DK, Berger A, Griffith A (1996) Invasion of respiratory epithelial cells by Burkholderia ( Pseudomonas ) cepacia . (springer.com)
  • On August 18, 2021, FDA requested healthcare providers, healthcare facility risk managers, and procurement staff to immediately stop using and discard all ultrasound gels and lotions manufactured by Eco-Med Pharmaceutical, Inc., due to risk of bacterial contamination with Burkholderia cepacia complex. (cdc.gov)
  • As of August 18, 2021, CDC is aware of at least 59 patients in 6 states with Burkholderia stabilis infection with a bacterial strain that genetically matches the B. stabilis strain identified in 4 lots of MediChoice M500812 ultrasound gel. (cdc.gov)
  • Bacterial evolution during chronic infections, particularly in pulmonary infections of persons with cystic fibrosis (CF), may involve adaptation to life in biofilms. (pnas.org)
  • This study provides experimental evidence supporting the importance of incorporating optimized in vivo imaging methods to monitor disease progression and to evaluate the efficacy of therapeutic treatment during bacterial infections. (mdpi.com)
  • Antioxidants - Fruits and vegetables are full antioxidants, and they help fight off bacterial infection. (naturalpedia.com)
  • Farcy is a subcutaneous form of the bacterial infection that presents with small papules and pustules at the site of skin inoculation. (oncologynurseadvisor.com)
  • Breaks in the cutaneous skin barrier, such as an abrasion or cut, may increase the risk of bacterial infection. (oncologynurseadvisor.com)
  • Our study illustrates a unique clinical case that contrasts a high-consequence infectious agent with a long-term commensal infection and provides further insights into bacterial evolution within the human host. (asm.org)
  • IMPORTANCE Some bacterial pathogens establish long-term infections that are difficult or impossible to eradicate with current treatments. (asm.org)
  • Thus, the T cell response to primary B. pseudomallei infection is biphasic, an early cytokine-induced phase in which T cells appear to be functionally redundant for initial bacterial clearance, followed by a later antigen-induced phase in which B. pseudomallei -specific T cells, in particular CD4 + T cells, are important for host resistance. (edu.au)
  • Bacterial numbers in the lungs reached approximately 10(8) cfu/ml at day 5 post-infection. (ox.ac.uk)
  • Burkholderia multivorans is an opportunistic pathogen capable of causing severe disease in patients with cystic fibrosis (CF). Patients may be chronically infected for years, during which the bacterial population evolves in response to unknown forces. (asm.org)
  • Comparison of bacterial burdens in aerosol-challenged mice, at both the pulmonary and distant sites of infection, suggests that C57Bl/6 mice were more efficient in clearing the bacteria than BALB/c mice. (microbiologyresearch.org)
  • Alveolar macrophages incubated in alcohol (0.08%) for 3 h prior to infection showed significantly lower bacterial uptake at 2 and 8 h post infection. (nih.gov)
  • Bacterial loads were assessed up to 7 days and survival was determined up to 7 days post infection. (edu.au)
  • Convergent evolution with other CF pathogens hints at a degree of predictability in bacterial evolution in the CF lung and potential targeted eradication of chronic CF infections in the future. (edu.au)
  • In 2003, Rogers and colleagues revolutionized our understanding of CF lung infections through their identification of complex bacterial communities in sputum and bronchoscopy samples using a culture-independent, molecular-based approach, terminal restriction fragment length polymorphism profiling. (plos.org)
  • This study was the first to recognize the role of highly prevalent and diverse bacterial species previously unrecognized in CF lung infections, including obligate anaerobes [ 1 ]. (plos.org)
  • Patients subsequently develop chronic, polymicrobial infections composed of diverse bacterial, fungal, and viral organisms. (plos.org)
  • All Bp ( N = 9) and four Bm strains were able to induce actin polymerization on the bacterial surface following infection. (biomedcentral.com)
  • Lytic phages are capable only of infections ending in bacterial cell death and release of new phage progeny (lytic life cycle), whilst temperate phages can either behave as lytic phages, or integrate into the genome of a bacterial host as a prophage (lysogenic life cycle) [ 1 ]. (mdpi.com)
  • These findings provide insights into a previously unexplored aspect of host response to infection, which can aid in future development of novel vaccines or therapeutics against bacterial pathogens. (gmu.edu)
  • The major global infectious diseases are usually managed with government or donor-supported systems, whereas basic laboratory testing for bacterial infections has no formal global programs. (stanford.edu)
  • Burkholderia mallei , the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective therapeutic treatments are lacking. (mdpi.com)
  • Culture results from skin lesions, abscesses, and respiratory aspirates will grow the gram-negative rod Burkholderia mallei. (oncologynurseadvisor.com)
  • The most recent case of glanders (in 2000) was diagnosed in a laboratory worker that was working with the Burkholderia mallei bacterium. (oncologynurseadvisor.com)
  • The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. (oncologynurseadvisor.com)
  • Glanders is caused by the zoonotic gram-negative nonencapsulated nonmotile aerobic bacterium, Burkholderia mallei. (oncologynurseadvisor.com)
  • Multilocus variable number tandem repeat analysis of a Burkholderia mallei strain isolated from a diseased dromedary in Bahrain revealed close genetic proximity to strain Dubai 7, which caused an outbreak of glanders in horses in the United Arab Emirates in 2004. (cdc.gov)
  • Glanders, a World Organisation for Animal Health (OIE)-listed disease, is a contagious, life-threatening disease of equids caused by the gram-negative bacterium Burkholderia mallei ( 1 ). (cdc.gov)
  • Natural B. mallei infections are known to occur in various mammals (e.g., cats, bears, wolves, and dogs). (cdc.gov)
  • Camels are also susceptible to B. mallei , as experimental infection has demonstrated ( 4 , 5 ). (cdc.gov)
  • In addition to horses and donkeys, dromedaries showed clinical signs of glanders, but B. mallei infection has not yet been confirmed. (cdc.gov)
  • Here we provide evidence for a B. mallei infection in 1 of the diseased dromedaries. (cdc.gov)
  • This organism is closely related to Burkholderia mallei , the etiological agent of glanders disease which primarily affects equines. (asm.org)
  • A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei. (semanticscholar.org)
  • Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. (semanticscholar.org)
  • Differences in levels of severity of B. cepacia infections in CF patients have been noted, and these may be due to variation in the types of virulence factors expressed among strains. (asm.org)
  • The majority of pyochelin-positive strains were isolated from patients with severe pulmonary disease, with more than half of infections resulting in death. (asm.org)
  • Pyochelin-negative strains were more frequently isolated from patients with moderate or mild infections ( 18 ). (asm.org)
  • In a subsequent study using a rat model of chronic pulmonary infection, exogenously supplied pyochelin was shown to increase the virulence of B. cepacia pyochelin-negative strains ( 20 ). (asm.org)
  • Bcc infections are a major concern in CF because some of the Bcc strains have high patient-to-patient transmissibility, multidrug resistance, and the potential to cause inflammation and fatal invasive disease ( 47 ). (asm.org)
  • Following patient segregation in cystic fibrosis medical care, the more virulent epidemic strains are not as frequent, and new infections are more likely to be with less virulent environmentally-acquired strains. (cochrane.org)
  • Employing three different clinical strains of B. pseudomallei and following the progression of disease development in both BALB/c and C57Bl/6 mice, we found that BALB/c mice were at least 10- to 100-fold more susceptible to infection than C57Bl/6 mice. (microbiologyresearch.org)
  • Overall, the B. pseudomallei strains showed evolutionary patterns similar to those of other chronic infections, including emergence of antibiotic resistance, genome reduction, and deleterious mutations in genes involved in virulence, metabolism, environmental survival, and cell wall components. (edu.au)
  • The goal of this study is to profile murine macrophage-mediated phenotypic and molecular responses that are characteristic to a collection of Bp, Bm, Burkholderia thailandensis (Bt) and Burkholderia oklahomensis (Bo) strains obtained from humans, animals, environment and geographically diverse locations. (biomedcentral.com)
  • These results characterize the phenotypic and immunological differences in the host innate response to pathogenic and avirulent Burkholderia strains and provide insight into the phenotypic alterations and molecular targets underlying host- Burkholderia interactions. (biomedcentral.com)
  • A novel, inducible Mu-like phage (vB_BvM-G4P1) was isolated from B. vietnamiensis G4 that had lytic activity against strains of five Burkholderia species prevalent in CF infections, including the Boston epidemic B. dolosa strain SLC6. (mdpi.com)
  • Background: Colonisation with Burkholderia cepacia is a poor prognostic indicator in subjects with cystic fibrosis (CF), but outcome prediction is impossible since patients are colonised by different strains with differing pathogenicity. (bmj.com)
  • While colonisation with Burkholderia cepacia in cystic fibrosis (CF) may carry a poor prognosis, different strains can vary in their pathogenicity. (bmj.com)
  • As a first step, we will isolate carbohydrate antigens from non-pathogenic strains of Burkholderia in forms that will generate appropriate immune responses. (sbir.gov)
  • During routine screening for Burkholderia pseudomallei from water wells in northern Australia in areas where it is endemic, Gram-negative bacteria (strains MSMB43 T , MSMB121, and MSMB122) with a similar morphology and biochemical pattern to B. pseudomallei and B. thailandensis were coisolated with B. pseudomallei on Ashdown's selective agar. (asm.org)
  • Cardona ST, Wopperer J, Eberl L, Valvano MA (2005) Diverse pathogenicity of Burkholderia cepacia complex strains in the Caenorhabditis elegans host model. (springer.com)
  • He investigates the role and function of pathogen-recognition-receptors and innate immunity in sepsis, with a special interest Burkholderia pseudomallei and Salmonella typhi infection and the role of diabetes as well as the gut microbiota during sepsis. (omicsonline.org)
  • This provides an incentive to better understand host-pathogen interfaces: on the pathogen side to unravel the mechanisms by which pathogens target and hijack host factors for their own benefit and on the host side to delineate how host cells marshal intracellular defense systems to combat infections. (jimmunol.org)
  • In less than 10 years, we have seen the status of this bacterium move from: (i) a lesser known pseudomonad opportunist pathogen, (ii) to devastating infections transmitted between patients with cystic fibrosis (CF), (iii) through divisions into several new species, and (iv) now on towards one of the largest gram-negative genome sequencing projects. (cf.ac.uk)
  • Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei. (ox.ac.uk)
  • Burkholderia cepacia may be a causative pathogen for nosocomial UTI in pediatric patients with predisposing factors , and appropriate selection of antimicrobial therapy is necessary because of high levels of resistance to empirical therapy , including aminoglycosides . (bvsalud.org)
  • Burkholderia cepacia is an important pathogen of humans in both immunocompromised or hospitalized patients . (bvsalud.org)
  • Burkholderia cepacia is a plant pathogen that is generally nonpathogenic for healthy humans. (asm.org)
  • Using our model of purifying exosomes from Burkholderia pseudomallei (Bp) infected cells, we aimed to better understand the role host exosomes play in the pathogenesis of Bp, a Category B priority pathogen that possess significant risk to public health and for which we currently have no effective countermeasures. (gmu.edu)
  • This bacterium was further identified as a member of Burkholderia , an opportunistic pathogen. (mdpi.com)
  • Over the past 20 years a group of closely related Burkholderia species termed the B. cepacia complex (Bcc) have emerged as opportunistic pathogens of particular importance in people with cystic fibrosis (CF) and chronic granulomatous disease ( 31 , 33 ). (asm.org)
  • Burkholderia cepacia complex ( Bc c) bacteria are opportunistic pathogens infecting hosts such as cystic fibrosis (CF) patients. (microbiologyresearch.org)
  • Collectively, these results demonstrate Acai PS is a potent innate immune agonist that can resolve F. tularensis and B. pseudomallei infections, suggesting this innate immune agonist has broad-spectrum activity against virulent intracellular pathogens. (openaire.eu)
  • PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients. (semanticscholar.org)
  • As a result, identification of host kinases that are targeted by Burkholderia during infection provides valuable molecular insights in understanding Burkholderia pathogenesis, and ultimately, in designing effective host-targeted therapies against infectious disease caused by intracellular pathogens. (osti.gov)
  • The risk of infection for cystic fibrosis patients from Burkholderia cepacia complex pathogens is of increasing concern to doctors and scientists. (sussex.ac.uk)
  • Burkholderia species have environmental, industrial and medical significance, and are important opportunistic pathogens in individuals with cystic fibrosis (CF). Using a combination of existing and newly determined genome sequences, this study investigated prophage carriage across the species B. vietnamiensis , and also isolated spontaneously inducible prophages from a reference strain, G4. (mdpi.com)
  • Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. (sbir.gov)
  • We will also assess the relative performance and compatibilities of existing antibodies to bind Burkholderia pathogens, in order to create optimized formulations, which will be assessed for therapeutic benefit in future challenge studies. (sbir.gov)
  • The Burkholderia cepacia complex (Bcc) is a group of 17 closely related species of the β-proteobacteria subdivision that emerged in the 1980s as important human pathogens, especially to patients suffering from cystic fibrosis. (springer.com)
  • Here we analyze the genomic and functional evolution of a B. multivorans infection that was sequentially sampled from a CF patient over 20 years. (asm.org)
  • The IST439 OAg biosynthetic gene cluster contains 7 of 23 genes that are closely homologous to genes found in B. multivorans , another member of the Burkholderia cepacia complex. (frontiersin.org)
  • The name Burkholderia multivorans has been proposed for genomovar II, while genomovar V has been identified as the previously named species Burkholderia vietnamiensis ( 4 ). (asm.org)
  • Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. (thefreelibrary.com)
  • We describe a clinical investigation of human infection with B. thailandensis in Chongqing, China. (cdc.gov)
  • Multicentre randomised clinical trials are needed to assess the effectiveness of different antibiotic regimens in people with cystic fibrosis infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence. (microbiologyresearch.org)
  • At follow up after 6 months, he had no clinical features of recurrent infection. (biomedcentral.com)
  • Burkholderia cepacia: current clinical issues, environmental controversies and ethical dilemmas. (semanticscholar.org)
  • The authors sought to analyze the incidence , clinical manifestation, risk factors , antimicrobial sensitivity and outcomes of B. cepacia urinary tract infection (UTI) in pediatric patients . (bvsalud.org)
  • Disk-diffusion tests performed according to the Clinical and Laboratory Standards Institute interpretive standards for Burkholderia cepacia ( 5 ) revealed that BF370 was sensitive to ceftazidime, meropenem, and trimethoprim/sulfamethoxazole. (cdc.gov)
  • However, no clinical information was presented, leading to the absence of clinical descriptions of the infections. (cdc.gov)
  • Although for some infections the etiology is still a mystery, while for others the causative microorganisms are present in minute concentrations long before the occurrence of first clinical symptoms, recent advances in genetic engineering and detection technologies are creating exciting opportunities for highly sensitive, specific and cost-effective products. (reportlinker.com)
  • Cescutti P, Bosco M, Picotti F, Impallomeni G, Leitão JH, Richau JA, Sá-Correia I (2000) Structural study of the exopolysaccharide produced by a clinical isolate of Burkholderia cepacia . (springer.com)
  • Of onions and men: Report of cavitary community acquired pneumonia due to Burkholderia cepacia complex in an immunocompetent patient and review of the literature. (medworm.com)
  • The known side effects of Burkholderia infection are similar to the symptoms linked with other diseases of the lungs like pneumonia and cystic fibrosis. (naturalpedia.com)
  • Two case reports described soft tissue infection and pneumonia with sepsis in Thailand and the United States ( 4 , 5 ). (cdc.gov)
  • Three German patients developed nosocomial pneumonia after cardiac surgery and had Burkholderia cepacia complex detected in respiratory specimens. (eurosurveillance.org)
  • In 2005, CDC notified several states cluster of pneumonia and other infection caused by B. cepacia associated with contaminated mouthwash. (coherentmarketinsights.com)
  • These infections may be associated with a fulminant necrotising pneumonia. (cochrane.org)
  • This aerobic gram-negative rod causes various clinically significant infections such as pneumonia , bacteremia , urinary tract infection , peritonitis , endophthalmitis , and keratitis . (bvsalud.org)
  • Burkholderia pseudomallei is an important cause of acute fulminant pneumonia and septicaemia in tropical regions of northern Australia and south east Asia. (bmj.com)
  • Treatment of respiratory tract infections caused by Mycoplasma pneumoniae . (drugs.com)
  • Treatment of respiratory tract infections caused by Haemophilus influenzae , Streptococcus pneumoniae , or Klebsiella . (drugs.com)
  • Burkholderia thailandensis infection in humans is uncommon. (cdc.gov)
  • We describe a case of B. thailandensis infection in a person in China, a location heretofore unknown for B. thailandensis . (cdc.gov)
  • Little is known about B. thailandensis infection in humans. (cdc.gov)
  • Virulence comparison of Burkholderia thailandensis isolated from a man in Chongqing, China, compared with B. thailandensis E264 (strain ATCC 700388). (cdc.gov)
  • during infection, we performed a RNA interference (RNAi) screen of the human kinome and identified 35 host kinases that facilitated Burkholderia thailandensis intracellular survival in human monocytic THP-1 cells. (osti.gov)
  • We focused on the role of the novel protein kinase C isoform, PKC-η, in Burkholderia infection and characterized PKC-η/MARCKS signaling as a key event that promotes the survival of unopsonized B. thailandensis CDC2721121 within host cells. (osti.gov)
  • Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. (wikipedia.org)
  • B. thailandensis is sometimes used to model B. pseudomallei infection in mice because of similarities in the immune response. (wikipedia.org)
  • Burkholderia thailandensis sp. (wikipedia.org)
  • How diversity evolves and persists in biofilms is essential for understanding much of microbial life, including the uncertain dynamics of chronic infections. (pnas.org)
  • Evolution in chronic infections therefore may be driven by mutations in relatively few pathways also favored during laboratory selection, creating hope that experimental evolution may illuminate the ecology and selective dynamics of chronic infections and improve treatment strategies. (pnas.org)
  • despite several recent surveys of evolution in the lungs of CF patients ( 10 ⇓ ⇓ - 13 ), the ecology of chronic infections remains a black box. (pnas.org)
  • Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with cystic fibrosis. (cochrane.org)
  • To identify whether treatment of Burkholderia cepacia complex infections can achieve eradication, or if treatment can prevent or delay the onset of chronic infection. (cochrane.org)
  • Here, we document within-host evolution of B. pseudomallei in a unique case of human infection with ongoing chronic carriage. (asm.org)
  • Chronic Burkholderia cepacia bronchiectasis in a non-cystic fibrosis individual. (microbiologyresearch.org)
  • Eventually, chronic pulmonary infection culminates in a decline in lung function, which becomes most severe during pulmonary exacerbations and late stage disease progression. (plos.org)
  • Depending on the route of exposure, aerosol or transcutaneous, infection by Bp or Bm can result in an extensive range of disease - from acute to chronic, relapsing illness to fatal septicemia. (biomedcentral.com)
  • These findings support a potential pathogenic role for B pseudomallei in CF lung disease, producing both chronic infection and possibly acute bronchopneumonia. (bmj.com)
  • Subacute and chronic forms of the disease also occur, albeit more commonly in non-endemic regions, and B pseudomallei is capable of causing pyogenic or granulomatous infection in virtually any tissue. (bmj.com)
  • Although this species has been identified as the most prevalent and pathogenic of the Burkholderia cepacia complex species in CF patients ( 14 ), relatively little is known about how it adapts to a biofilm lifestyle or to the CF lung environment ( 5 , 16 ). (pnas.org)
  • The Burkholderia cepacia complex (Bcc) is a group of closely related gram-negative bacteria comprising at least 9 species (1). (thefreelibrary.com)
  • No studies looking at the eradication of Burkholderia cepacia complex species were identified. (cochrane.org)
  • Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. (cochrane.org)
  • This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. (ox.ac.uk)
  • The genus Burkholderia , first proposed in 1992, has now expanded to consist of many species ( 1 ). (cdc.gov)
  • PCR assays targeting rRNA genes were developed to identify species (genomovars) within the Burkholderia cepacia complex. (asm.org)
  • Moreover, the effects of infection depend on the insect species, the parasite strain, and environmental conditions involved. (ajtmh.org)
  • Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp nov and Burkholderia lata sp nov. (ugent.be)
  • Burkholderia pseudomallei are a gram negative, bipolar, aerobic, motile rod-shaped soil dwelling bacterium. (reportbuyer.com)
  • Sfeir MM . Burkholderia cepacia complex infections: more complex than the bacterium name suggest. (eurosurveillance.org)
  • Burkholderia pseudomallei is considered a highly pathogenic bacterium because infection is commonly fatal. (asm.org)
  • Unfortunately, treating a B. pseudomallei infection is difficult as the bacterium is intrinsically resistant to many antibiotics and relapse following apparently successful therapy is well recognized ( Cheng and Currie, 2005 ). (frontiersin.org)
  • The primary route of infection with B. pseudomallei is believed to be through skin inoculation of the soil-dwelling bacterium. (health.mil)
  • For microbiologists, hospital infection control officers, caregivers, and most of all the CF community, the changes in our understanding of the taxonomy, epidemiology and pathogenesis of the bacterium 'B. cepacia' are complex. (cf.ac.uk)
  • Pathogenic Burkholderia rely on host factors for efficient intracellular replication and are highly refractory to antibiotic treatment. (osti.gov)
  • Although it has been argued that T. cruzi is not pathogenic for this vector, other studies indicate that the success of the infection depends on several molecules and factors, including the insect's intestinal microbiota, which may experience changes as a result of infection that include decreased fitness. (ajtmh.org)
  • Glanders is a life-threatening infection of the pulmonary system. (oncologynurseadvisor.com)
  • Randomised and quasi-randomised controlled trials of treatments for exacerbations of pulmonary symptoms in people with cystic fibrosis chronically infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • 100 136 Although the usual duration of treatment for drug-susceptible pulmonary and extrapulmonary TB (except disseminated infections and TB meningitis) is 6-9 months, 100 136 ATS, CDC, and IDSA state that completion of treatment is determined more accurately by the total number of doses and should not be based solely on the duration of therapy. (drugs.com)
  • Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections. (openaire.eu)
  • Pulmonary Francisella tularensis and Burkholderia pseudomallei infections are highly lethal in untreated patients, and current antibiotic regimens are not always effective. (openaire.eu)
  • Likewise, nasal Acai PS treatment conferred protection against pulmonary infection with B. pseudomallei strain 1026b. (openaire.eu)
  • Nasal administration of Acai PS enhanced IFN-γ responses by NK and γδ T cells in the lungs, while neutralization of IFN-γ totally abrogated the protective effect of Acai PS against pulmonary B. pseudomallei infection. (openaire.eu)
  • Patients have developed Bcc infections, including bloodstream infections, after likely having undergone ultrasound-guided procedures in which MediChoice ® M500812 ultrasound gel was used. (cdc.gov)
  • B. cepacia can also cause central venous catheter-related infections in cancer patients and those on hemodialysis. (naturalpedia.com)
  • Since B. cepacia can infect the respiratory tract of patients with cystic fibrosis, eating foods rich in antioxidants, calcium, and fiber can help prevent Burkholderia infection. (naturalpedia.com)
  • The purpose of this research study was to determine if an experimental drug called Aztreonam for Inhalation Solution (AZLI) was safe and effective to treat Burkholderia lung infections in patients with cystic fibrosis (CF). (clinicaltrials.gov)
  • As a result of concern over excessive mortality after lung transplantation, many transplant programs refuse to accept cystic fibrosis (CF) patients infected with Burkholderia cepacia. (nih.gov)
  • 42 mechanically ventilated patients who developed respiratory tract colonization or infection with B. cepacia and 135 ventilator-dependent controls who were not colonized and did not develop infections. (annals.org)
  • 42 patients had B. cepacia respiratory tract colonization or infection. (annals.org)
  • Observation of intensive care unit and respiratory care personnel showed faulty infection control procedures (for example, the same multiple-dose bottle of albuterol was used for many mechanically ventilated patients). (annals.org)
  • Patients with lung disease such as asthma, CFTR, and COPD are at high risk of suffering from Burkholderia infection. (coherentmarketinsights.com)
  • Characteristics of patients with Burkholderia cepacia bacteremia. (microbiologyresearch.org)
  • Burkholderia lata was isolated from 8 intensive care patients at 2 tertiary hospitals in Australia. (cdc.gov)
  • Long-term Bc c infection of CF patients' airways has been associated with emergence of phenotypic variation. (microbiologyresearch.org)
  • 109 j k l Anti-infectives also are indicated in patients with B. henselae infections who develop bacillary angiomatosis, neuroretinitis, or Parinaud's oculoglandular syndrome. (drugs.com)
  • In addition to the recalled liquid products manufactured by PharmaTech, CDC and FDA continue to recommend that clinicians and patients not use any brand of liquid docusate sodium product as a stool softener or for any other medical purpose, as some of the infections reported identify docusate sodium products manufactured by other companies other than PharmaTech. (cdc.gov)
  • Comparison of isolation media for recovery of Burkholderia cepacia complex from respiratory secretions of patients with cystic fibrosis. (semanticscholar.org)
  • Burkholderia cepacia is an aerobic, glucose -non-fermenting, gramnegative bacillus that mainly affects immunocompromised and hospitalized patients . (bvsalud.org)
  • however, with the advent of improved culture methods and culture-independent approaches, including deep sequencing technology, it is clear that the airways of patients with CF are chronically colonized with complex, polymicrobial infections. (plos.org)
  • About ninety five percent of patients succumb to untreated septicemic infections and the fatality rate is 50 % even when standard antibiotic treatments are administered. (biomedcentral.com)
  • More recently, members of the Bcc have been associated with serious and sometimes fatal infections of the lower respiratory tract, primarily in compromised individuals and particularly cystic fibrosis (CF) patients ( 14 , 22 ). (asm.org)
  • Despite the advances that have been made in the understanding of the taxonomy and epidemiology of this group, infections of the respiratory tract with B . cepacia complex organisms still have a considerable impact on morbidity and mortality in cystic fibrosis (CF) patients ( 4 , 5 , 6 ). (asm.org)
  • Background: Colonisation with Burkholderia cepacia complex in patients with cystic fibrosis (CF) has been associated with adverse outcomes. (cf.ac.uk)
  • Four patients are described with a mean duration of infection of 32 months. (bmj.com)
  • Two patients (with the longest duration of infection) deteriorated clinically and one subsequently died of respiratory failure. (bmj.com)
  • However, even after successful organ transplantation, patients realise the often inflated, unrealistic character of their previous expectations due to their continuing dependence on medication, regular control examinations and a higher risk of infections and allograft rejections. (clinicaltrials.gov)
  • Patients positive for human immunodeficiency virus (HIV) or Burkholderia cepacia infection. (clinicaltrials.gov)
  • CDC is collaborating with the Food and Drug Administration (FDA), state and local health departments, and healthcare facilities to investigate recent outbreak of Burkholderia cepacia infections associated with exposure to liquid docusate. (cdc.gov)
  • PharmaTech liquid docusate products were also implicated in an outbreak of B. cepacia infections in 2016. (cdc.gov)
  • Outbreak of Burkholderia cepacia pseudobacteraemia caused by intrinsically contaminated commercial 0.5% chlorhexidine solution in neonatal intensive care units. (eurosurveillance.org)
  • An outbreak of Burkholderia cepacia complex associated with intrinsically contaminated nasal spray. (eurosurveillance.org)
  • Three-year outbreak of pseudobacteremia with Burkholderia cepacia traced to a contaminated blood gas analyzer. (eurosurveillance.org)
  • An outbreak of Burkholderia cepacia complex infections associated with contaminated liquid docusate. (eurosurveillance.org)
  • The agency confirmed the product had been contaminated with Burkholderia cepacia , a bacteria linked to an outbreak in five states. (cdc.gov)
  • MLST phylogenetic tree of the outbreak Burkholderia lata from Australasian sublineage. (cdc.gov)
  • A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. (eurosurveillance.org)
  • In October, 2016, Nurse Assist Inc, recalled its normal saline flush IV syringes due to Burkholderia Cepacia bloodstream infection. (coherentmarketinsights.com)
  • On August 9, 2016, FDA issued a statement alerting healthcare professionals and consumers of a voluntary nationwide recall of all liquid products manufactured by PharmaTech and distributed by the following companies: Rugby, Major, Bayshore, Metron, Centurion, and Virtus, due to possible Burkholderia cepacia contamination. (cdc.gov)
  • Our results indicate that protection of CpG-treated animals was associated with recruitment of neutrophils prior to infection and demonstrated, for the first time, simultaneous real time in vivo imaging of neutrophils and bacteria. (mdpi.com)
  • Burkholderia infection is caused by the Burkholderia cepacia bacteria . (naturalpedia.com)
  • The organism is highly infective and infection of the host only requires a a small number of bacteria. (oncologynurseadvisor.com)
  • One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. (cochrane.org)
  • These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. (cochrane.org)
  • We did not find any trials which compared groups of volunteers with exacerbations who were also infected with Burkholderia cepacia complex bacteria, who were given different treatments at random. (cochrane.org)
  • More research is needed to find out which treatments are best for improving lung function and survival and for reducing side effects and length of time spent in hospital for people infected with Burkholderia cepacia complex bacteria experiencing an exacerbation. (cochrane.org)
  • Burkholderia cepacia complex bacteria are resistant to many common antibiotics and able to acquire resistance against many more. (cochrane.org)
  • 111 113 114 Should only be used for treatment of infections caused by these bacteria when in vitro susceptibility tests indicate the organism is susceptible. (drugs.com)
  • IMPORTANCE Bacteria may become genetically and phenotypically diverse during long-term colonization of cystic fibrosis (CF) patient lungs, yet our understanding of within-host evolutionary processes during these infections is lacking. (asm.org)
  • Our obsession with bacteria from the Burkholderia cepacia complex started in the early 1990s. (cf.ac.uk)
  • Infection with Bp can occur via percutaneous inoculation, injection or inhalation of aerosolized bacteria or contaminated fluids [ 1 ]. (biomedcentral.com)
  • The Burkholderia cepacia complex (Bcc) is a large and diverse group of related gram-negative bacteria, which inhabit a wide range of environmental niches, including freshwater and soil. (asm.org)
  • Formulate corrective measures for pipeline projects by understanding Burkholderia pseudomallei Infections (Infectious Disease) pipeline depth and focus of Indication therapeutics. (reportbuyer.com)
  • CDC is assisting the Food and Drug Administration (FDA) and several state and local health departments with an ongoing investigation of Burkholderia cepacia complex (Bcc) infections in healthcare facilities. (cdc.gov)
  • We describe a case of an otherwise healthy, community-dwelling man who presented with subacute cavitary lung disease, the causative organism of which turned out to be Burkholderia cepacia complex. (medworm.com)
  • We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. (cochrane.org)
  • Without further comprehensive studies, it is difficult to draw conclusions about a safe and effective management strategy for Burkholderia cepacia complex eradication in cystic fibrosis. (cochrane.org)
  • There remain no objective guidelines for strategies to eradicate Burkholderia cepacia complex in cystic fibrosis lung disease, as these are inherently resistant to the majority of antibiotics and there has been very little research in this area. (cochrane.org)
  • This review aims to examine the current treatment options for people with cystic fibrosis with acute infection with Burkholderia cepacia complex and to identify an evidence-based strategy that is both safe and effective. (cochrane.org)
  • Randomised or quasi-randomised studies in people with cystic fibrosis of antibiotics or alternative therapeutic agents used alone or in combination, using any method of delivery and any treatment duration, to eradicate Burkholderia cepacia complex infections compared to another antibiotic, placebo or no treatment. (cochrane.org)
  • Jacobson M , Wray R , Kovach D , Henry D , Speert D , Matlow A . Sustained endemicity of Burkholderia cepacia complex in a pediatric institution, associated with contaminated ultrasound gel. (eurosurveillance.org)
  • Which antibiotics are best to treat worsening symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection? (cochrane.org)
  • Burkholderia cepacia complex infections present a significant challenge for people with cystic fibrosis and their clinicians. (cochrane.org)
  • To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation and chronically infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • Update on the Burkholderia cepacia complex. (microbiologyresearch.org)
  • Historically, H . influenzae and S . aureus were considered to be the primary organisms infecting the airways of infants and children with CF, followed by P . aeruginosa or Burkholderia cepacia complex during adulthood. (plos.org)
  • Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex. (nih.gov)
  • Ball R, Brownlee KG, Duff AJ, Denton M, Conway SP, Lee TW (2010) Can Burkholderia cepacia complex be eradicated with nebulised Amiloride and TOBI? (springer.com)
  • Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M (2007) Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. (springer.com)
  • The variable severity of Burkholderia cepacia complex infections in cystic fibrosis (CF) has recently been ascribed to differences in the virulence between genomovars. (hindawi.com)
  • While B. pseudomallei infections can occur in healthy humans, binge alcohol use is progressively being recognized as a major risk factor. (nih.gov)
  • These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. (sbir.gov)
  • It is closely related to Burkholderia pseudomallei, but unlike B. pseudomallei, it only rarely causes disease in humans or animals. (wikipedia.org)
  • Burkholderia cepacia is resistant to multiple antibiotic such as aminoglycosides, antipseudomonal third-generation cephalosporins and antipseudomonal penicillins. (coherentmarketinsights.com)
  • Activating the innate immune system provides an alternative means of treating infection and can also complement antibiotic therapies. (openaire.eu)
  • Tigecycline in combination with ceftazidime was the most effective and conferred the lowest mortality, suggesting the use of this new agent in B. pseudomallei infection. (edu.au)
  • It is endemic in South East Asia and Australia[ 1 ] where it causes infections with protean manifestations. (biomedcentral.com)
  • Burkholderia pseudomallei is endemic in the tropics and associated with high mortality. (confex.com)
  • Burkholderia cepacia is an aerobic, Gram-negative bacillus, which exhibits innate resistance to multiple antibiotics and disinfectants. (microbiologyresearch.org)
  • North America is expected to account for maximum share of the global burkholderia infections market, owing to the better diagnostic facilities, increasing awareness and government initiative for early diagnosis and treatment of burkholderia infection. (coherentmarketinsights.com)
  • If you suspect patient infection(s) possibly associated with a medical product, we encourage you to alert your local or state health department and submit a voluntary report to MedWatch, the FDA Safety Information and Adverse Event Reporting program external icon . (cdc.gov)
  • We have recently isolated Burkholderia pseudomallei from an Eritrean patient in Israel. (ajtmh.org)
  • In 2004, Burkholderia Cepacia was linked to nosocomial infection among Intensive Care Unit patient and was associated with exposure to sublingual probes. (coherentmarketinsights.com)
  • Matthaiou DK , Chasou E , Atmatzidis S , Tsolkas P . A case of bacteremia due to Burkholderia cepacia in a patient without cystic fibrosis. (microbiologyresearch.org)
  • consultation with a specialist is particularly important when the patient cannot tolerate first-line drugs or when the infection has not responded to prior therapy or is caused by macrolide-resistant MAC. (drugs.com)
  • Using these products in a patient whose immune system is compromised could result in infections, which may be life-threatening. (cdc.gov)
  • The isolation of B. fungorum from the synovial tissue of this patient, however, is similar to an earlier case of leg tissue infection in a girl ( 3 ). (cdc.gov)
  • Four reports of B pseudomallei infection in subjects with cystic fibrosis (CF) have recently been published. (bmj.com)
  • However, whole-genome sequencing suggests a polyclonal infection. (nt.gov.au)
  • One potential virulence factor implicated in the pathogenesis of B. cepacia infections is the production of siderophores. (asm.org)
  • Bernier SP, Silo-Suh L, Woods DE, Ohman DE, Sokol PA (2003) Comparative analysis of plant and animal models for characterization of Burkholderia cepacia virulence. (springer.com)
  • for Burkholderia vietnamiensis (genomovar V), sensitivity and specificity were 87 and 92%, respectively. (asm.org)
  • Induction of multiple chemokine and colony-stimulating factor genes in experimental Burkholderia pseudomallei infection. (microbiologyresearch.org)
  • To identify host genes that are required by Burkholderia spp. (osti.gov)
  • Hierarchical clustering of transcriptional data from 84 mouse cytokines, chemokines and their corresponding receptors identified 29 host genes as indicators of differential responses between the Burkholderia spp. (biomedcentral.com)
  • Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst quinolones and aminoglycosides have no reliable effect. (frontiersin.org)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Burkholderia pseudomallei Infections (Infectious Disease). (reportbuyer.com)
  • Understanding the disease susceptibility and pathogenesis is crucial for developing newer diagnostic and therapeutic strategies for this life-threatening infection. (asm.org)
  • Burkholderia cepacia has high levels of resistance to many antimicrobial agents , and therapeutic options are limited. (bvsalud.org)
  • This study highlights how genomic characterization of Burkholderia prophages can lead to the discovery of novel bacteriophages with potential therapeutic or biotechnological applications. (mdpi.com)
  • Ashdown's medium (or Burkholderia cepacia medium) may be used for selective isolation. (wikipedia.org)
  • The MH-S alveolar macrophage (AMs) cell line was used to characterize innate immune responses to infection in vitro. (nih.gov)
  • Burkholderia cepacia is a gram negative bacilli usually isolated from persons with genetic lung diseases such as Cystic fibrosis. (semanticscholar.org)
  • This review of literature gives an idea of the organism and the gateway it opens for further research with a special note on the evolution of this genus as a nosocomial infection in Neonates. (semanticscholar.org)
  • We confirm a natural infection of dromedaries with glanders. (cdc.gov)
  • Multiple-dose medications and reliance on benzalkonium chloride as a medication preservative provide a mechanism for nosocomial spread of microorganisms, particularly if infection control procedures are not carefully followed. (annals.org)
  • With limitations in treatment and lack of a vaccine, it is crucial to study the immune response mechanisms to this infection to get a better understanding of disease susceptibility and pathogenesis. (asm.org)