Burkholderia mallei: A species of gram-negative bacteria parasitic on HORSES and DONKEYS causing GLANDERS, which can be transmitted to humans.Glanders: A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.Burkholderia Infections: Infections with bacteria of the genus BURKHOLDERIA.Burkholderia: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.Burkholderia pseudomallei: A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.Luminescence: Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.Melioidosis: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Burkholderia cepacia: A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.Malleus: The largest of the auditory ossicles, and the one attached to the membrana tympani (TYMPANIC MEMBRANE). Its club-shaped head articulates with the INCUS.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Mice, Inbred BALB CLiver Abscess: Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.Dourine: A disease of horses and donkeys caused by Trypanosoma equiperdum. The disease occurs in Africa, the Americas, and Asia.Biological Warfare Agents: Living organisms or their toxic products that are used to cause disease or death of humans during WARFARE.Employment: The state of being engaged in an activity or service for wages or salary.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)EnglandOligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Burkholderia cepacia complex: A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Cystic Fibrosis Transmembrane Conductance Regulator: A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)Burkholderia cenocepacia: A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Mucus: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.Emergency Medical Service Communication Systems: The use of communication systems, such as telecommunication, to transmit emergency information to appropriate providers of health services.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.

Comparison of isolation media for recovery of Burkholderia cepacia complex from respiratory secretions of patients with cystic fibrosis. (1/346)

Burkholderia cepacia selective agar (BCSA) has previously been devised for isolation of B. cepacia from respiratory secretions of patients with cystic fibrosis and tested under research laboratory conditions. Here we describe a study in which BCSA, oxidation-fermentation polymyxin bacitracin lactose agar (OFPBL), and Pseudomonas cepacia agar (PCA) were compared in routine culture procedures for the ability to grow B. cepacia and inhibit other organisms. Three hundred twenty-eight specimens from 209 patients at two pediatric centers and 328 specimens from 109 adults were tested. Plates were inoculated, incubated, and read for quality and quantity of growth at 24, 48, and 72 h. Five (1.5%) specimens from 4 (1.9%) children and 75 (22.9%) specimens from 16 (14.7%) adults grew B. cepacia complex. At 24, 48, and 72 h, BCSA achieved 43, 93, and 100% detection, respectively; OFPBL achieved 26, 84, and 96%, respectively; and PCA achieved 33, 74, and 84% detection, respectively. Quality was assessed as pinpoint or good growth. At 24 h, most cultures growing B. cepacia complex had pinpoint colonies. By 48 and 72 h, 48 and 69% of B. cepacia complex cultures, respectively, had good growth on BCSA, while on OFPBL 19 and 30%, respectively, had good growth and on PCA 11 and 18%, respectively, had good growth. BCSA was superior to OFPBL and PCA in suppressing organisms other than B. cepacia complex; 40 non-B. cepacia complex organisms were isolated from BCSA, 263 were isolated from OFPBL, and 116 were isolated from PCA. We conclude that BCSA is superior to OFPBL and PCA in its ability to support the growth of B. cepacia complex and to suppress other respiratory organisms.  (+info)

Structural elucidation of a novel exopolysaccharide produced by a mucoid clinical isolate of Burkholderia cepacia. Characterization of a trisubstituted glucuronic acid residue in a heptasaccharide repeating unit. (2/346)

The structure of the exopolysaccharide (EPS) produced by a clinical isolate of Burkholderia cepacia isolated from a patient with fibrocystic lung disease has been investigated. By means of methylation analyses, carboxyl reduction, partial depolymerization by fuming HCl and chemical degradations such as Smith degradation, lithiumethylenediamine degradation and beta-elimination, supported by GC/MS and NMR spectroscopic analyses, the repeat unit of the EPS has been identified and was shown to correspond to the acidic branched heptasaccharide with the following structure: [formula: see text]. This partially acetylated acidic polymer, distinguished by the presence of the less usual D-isomer of rhamnose and of a trisubstituted glucuronic acid residue, could represent the main EPS produced by this bacterial species.  (+info)

An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. (3/346)

Burkholderia cepacia is an important pathogen in cystic fibrosis (CF) and an infrequent cause of nosocomial infection in non-CF patients. This report describes a large hospital outbreak that appeared to involve both patient groups, a previously unrecognized phenomenon. Ribotype restriction fragment length polymorphism (RFLP) profiles and pulsed-field gel electrophoresis-resolved macrochromosomal RFLPs were analyzed, a ribotype-based phylogenic tree was constructed, and case-control and cohort studies were performed. A single dominant clone was found in both CF and non-CF groups. Phylogenic analysis suggests that it has evolved independently and that such highly transmissible strains can emerge rapidly and randomly. Acquisition risk in the CF patients was linked to hospitalization (odds ratio=5.47, P=.0158, confidence interval=1. 28-26.86) and was associated with significantly increased mortality rates. Infection control policies must now consider this threat of transmission between non-CF and CF patients.  (+info)

Identification of Burkholderia spp. in the clinical microbiology laboratory: comparison of conventional and molecular methods. (4/346)

Cystic fibrosis (CF) predisposes patients to bacterial colonization and infection of the lower airways. Several species belonging to the genus Burkholderia are potential CF-related pathogens, but microbiological identification may be complicated. This situation is not in the least due to the poorly defined taxonomic status of these bacteria, and further validation of the available diagnostic assays is required. A total of 114 geographically diverse bacterial isolates, previously identified in reference laboratories as Burkholderia cepacia (n = 51), B. gladioli (n = 14), Ralstonia pickettii (n = 6), B. multivorans (n = 2), Stenotrophomonas maltophilia (n = 3), and Pseudomonas aeruginosa (n = 11), were collected from environmental, clinical, and reference sources. In addition, 27 clinical isolates putatively identified as Burkholderia spp. were recovered from the sputum of Dutch CF patients. All isolates were used to evaluate the accuracy of two selective growth media, four systems for biochemical identification (API 20NE, Vitek GNI, Vitek NFC, and MicroScan), and three different PCR-based assays. The PCR assays amplify different parts of the ribosomal DNA operon, either alone or in combination with cleavage by various restriction enzymes (PCR-restriction fragment length polymorphism [RFLP] analysis). The best system for the biochemical identification of B. cepacia appeared to be the API 20NE test. None of the biochemical assays successfully grouped the B. gladioli strains. The PCR-RFLP method appeared to be the optimal method for accurate nucleic acid-mediated identification of the different Burkholderia spp. With this method, B. gladioli was also reliably classified in a separate group. For the laboratory diagnosis of B. cepacia, we recommend parallel cultures on blood agar medium and selective agar plates. Further identification of colonies with a Burkholderia phenotype should be performed with the API 20NE test. For final confirmation of species identities, PCR amplification of the small-subunit rRNA gene followed by RFLP analysis with various enzymes is recommended.  (+info)

Differentiation of Burkholderia species by PCR-restriction fragment length polymorphism analysis of the 16S rRNA gene and application to cystic fibrosis isolates. (5/346)

Burkholderia cepacia, which is an important pathogen in cystic fibrosis (CF) owing to the potential severity of the infections and the high transmissibility of some clones, has been recently shown to be a complex of five genomic groups, i.e., genomovars I, II (B. multivorans), III, and IV and B. vietnamiensis. B. gladioli is also involved, though rarely, in CF. Since standard laboratory procedures fail to provide an accurate identification of these organisms, we assessed the ability of restriction fragment length polymorphism (RFLP) analysis of amplified 16S ribosomal DNA (rDNA), with the combination of the patterns obtained with six endonucleases, to differentiate Burkholderia species. This method was applied to 16 type and reference strains of the genus Burkholderia and to 51 presumed B. cepacia clinical isolates, each representative of one clone previously determined by PCR ribotyping. The 12 Burkholderia type strains tested were differentiated, including B. cepacia, B. multivorans, B. vietnamiensis, and B. gladioli, but neither the genomovar I and III reference strains nor the genomovar IV reference strain and B. pyrrociniaT were distinguishable. CF clinical isolates were mainly distributed in RFLP group 2 (which includes B. multivoransT) and RFLP group 1 (which includes B. cepacia genomovar I and III reference strains, as well as nosocomial clinical isolates). Two of the five highly transmissible clones in French CF centers belonged to RFLP group 2, and three belonged to RFLP group 1. The remaining isolates either clustered with other Burkholderia species (B. cepacia genomovar IV or B. pyrrocinia, B. vietnamiensis, and B. gladioli) or harbored unique combinations of patterns. Thus, if further validated by hybridization studies, PCR-RFLP of 16S rDNA could be an interesting identification tool and contribute to a better evaluation of the respective clinical risks associated with each Burkholderia species or genomovar in patients with CF.  (+info)

Analysis of fliC variation among clinical isolates of Burkholderia cepacia. (6/346)

PCR and restriction fragment length polymorphism (RFLP) typing of flagellin genes (fliC) from 57 clinical isolates of Burkholderia cepacia indicated that only type 11 flagellins were present. Twenty-two isolates previously identified as the epidemic UK cystic fibrosis strain were indistinguishable by this method, as were 11 isolates from a pseudo-outbreak in Senegal. Other clinical isolates, including 19 from disparate sources in Malaysia, were separated into nine fliC RFLP groups, exhibiting a large degree of divergence. When isolates were indistinguishable by fliC genotyping, their similarity was confirmed by whole genome macro-restriction analysis with pulsed-field gel electrophoresis following XbaI digestion. The variation in fliC sequences of B. cepacia was far greater than that with B. pseudomallei, supporting the view that 'B. cepacia', as currently defined, may comprise several different genomic species.  (+info)

A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen. (7/346)

Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon knockout (GKO) BALB/c mice to facilitate dissection of components of pathogenicity and host defense. Both WT and GKO mice were susceptible to chronic splenic infection with B. cepacia, but not with Pseudomonas aeruginosa. B. cepacia strains from patients with CGD persisted longer than those from CF patients. C57BL/6 mice were the most susceptible murine strain; bacteria persisted in the spleen for 2 months. DBA/2, BALB/c, and A/J strains of mice were relatively resistant to infection. Certain strains of B. cepacia complex can persist in the murine spleen after systemic infection; this may provide clues to its virulence in compromised hosts, such as those with CGD and CF.  (+info)

Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebae. (8/346)

Members of the taxonomically diverse Burkholderia cepacia complex have become a major health risk for patients with cystic fibrosis (CF). Although patient-to-patient transmission of B. cepacia strains has been well-documented, very little is known about possible vehicles of transmission and reservoirs for these micro-organisms. In this work, it is shown that strains of the B. cepacia complex can survive within different isolates of the genus Acanthamoeba. Trophozoites containing bacteria developed profuse cytoplasmic vacuolization. Vacuolization was not detected in trophozoites infected with live Escherichia coli or heat-killed B. cepacia, or by incubation of trophozoites with filter-sterilized culture supernatants, indicating that metabolically active intracellular bacteria are required for the formation of vacuoles. Experiments with two different B. cepacia strains and two different Acanthamoeba isolates revealed that bacteria display a low level of intracellular replication approximately 72-96 h following infection. In contrast, extracellular bacteria multiplied efficiently on by-products released by amoebae. The findings suggest that amoebae may be a reservoir for B. cepacia and possibly a vehicle for transmission of this opportunistic pathogen among CF patients.  (+info)

*Streptomycin

This includes tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, ... At the end of World War II, the United States Army experimented with streptomycin to treat life-threatening infections at a ... Tularemia infections have been treated mostly with streptomycin. Streptomycin is traditionally given intramuscularly, and in ... Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell ...

*Melioidosis

2011). "Burkholderia pseudomallei infection in a child with cystic fibrosis: acquisition in the western hemisphere". Chest. 140 ... It is phylogenetically related closely to Burkholderia mallei which causes glanders, an infection primarily of horses, donkeys ... Holland DJ, Wesley A, Drinkovic D, Currie BJ (2002). "Cystic fibrosis and Burkholderia pseudomallei infection: an emerging ... Chlebicki, MP; Tan BH (2006). "Six cases of suppurative lymphadenitis caused by Burkholderia pseudomallei infection". ...

*List of MeSH codes (C01)

... burkholderia infections MeSH C01.252.400.170.400 --- glanders MeSH C01.252.400.170.531 --- melioidosis MeSH C01.252.400.177 ... bacteroides infections MeSH C01.252.400.126 --- bartonellaceae infections MeSH C01.252.400.126.100 --- bartonella infections ... acinetobacter infections MeSH C01.252.400.610 --- mycoplasmatales infections MeSH C01.252.400.610.610 --- mycoplasma infections ... bordetella infections MeSH C01.252.400.143.740 --- whooping cough MeSH C01.252.400.155 --- borrelia infections MeSH C01.252. ...

*Burkholderia thailandensis

"Arabinose-positive Burkholderia pseudomallei infection in humans: case report". Clin Infect Dis. 28 (4): 927-28. doi:10.1086/ ... Brett PJ, DeShazer D, Woods DE (1998). "Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species". Int J ... "Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection". Microb Pathog. 48 (1): 9- ... Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. It is closely ...

*Caspase 6

"Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental ...

*Burkholderia mallei

... or splenous infections. B. mallei infection has a fatality rate of 95% if left untreated, and a 50% fatality rate in ... Burkholderia mallei is a Gram-negative, bipolar, aerobic bacterium, a Burkholderia-genus human and animal pathogen causing ... Pathema-Burkholderia Resource "Glanders (Burkholderia mallei) General Information". Centers for Disease Control and Prevention ... Galyov EE, Brett PJ, DeShazer D (2010). "Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis ...

*Innate immune system

... biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic ... The flushing action of tears and saliva helps prevent infection of the eyes and mouth. Inflammation is one of the first ... In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that very few ... Walling off or discarding a part of a plant helps stop spread of an infection. Most plant immune responses involve systemic ...

*Burkholderia cepacia complex

"Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence". ... UMR: Burkholderia cepacia CFF: Research Pathema-Burkholderia Resource Loutet SA, Valvano MA (October 2010). "A decade of ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ... "Burkholderia cepacia complex". NCBI Taxonomy Browser. 87882. Type strain of Burkholderia cepacia complex at BacDive - the ...

*Burkholderia gladioli

... in humans is an opportunistic pathogen that is an important agent for hospital-associated infections. It ... PubMed article on PCR identification of Burkholderia EMedicine overview of Burkholderia Type strain of Burkholderia gladioli at ... Burkholderia gladioli is closely related to, and often mistaken for, a member of the Burkholderia cepacia complex. This ... Burkholderia gladioli can be distinguished from the other Burkholderia because it is oxidase negative B. gladioli is indole ...

*Immune system

Such biofilms are present in many successful infections, e.g., the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia ... urinary tract infection and post-surgical infections. Inflammation is one of the first responses of the immune system to ... This is "adaptive" because it occurs during the lifetime of an individual as an adaptation to infection with that pathogen and ... Long-term active memory is acquired following infection by activation of B and T cells. Active immunity can also be generated ...

*Walter H. Burkholder

Journal of Infection in Developing Countries Burkholderia cepacia:Friend or Foe? - Jennifer L. Parke Annual Review of ... Bacterial strains from the Burkholderia cepacia complex (Bcc) are opportunistic pathogens in humans with cystic fibrosis and ... In 1950 he first described the bacteria, Pseudomonas cepacia, later Burkholderia spp., responsible for causing sour skin ...

*HLA-DR16

Burkholderia pseudomallei infection) DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk *1602:DQA1* ... "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890-5 ... 0102:DQB1*0502 haplotype: graves disease, cervical cancer (human papilloma virus infection), scleroderma *1602:DQA1*05:DQB1* ...

*Sharon Peacock

... infection mechanisms of Burkholderia pseudomallei and Melioidosis. Peacock has published around 150 papers on these topics. ... She is particularly known for her work on the bacterium Burkholderia pseudomallei and on Methicillin-resistant Staphylococcus ... on genomics highlights the potential for pathogen genomics in patient diagnosis and infection control - On Medicine". On ...

*Glanders

It is caused by infection with the bacterium Burkholderia mallei, usually by ingestion of contaminated feed or water. Signs of ... No vaccine is licensed for use in the U.S. Infection with either of these bacteria results in nonspecific symptoms and can be ... Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is ... Attempts have been made to develop vaccines for these infections, which would not only benefit military personnel, a group most ...

*Cystic fibrosis

Antibiotics by mouth such as ciprofloxacin or azithromycin are given to help prevent infection or to control ongoing infection ... Eventually, Pseudomonas aeruginosa (and sometimes Burkholderia cepacia) dominates. By 18 years of age, 80% of patients with ... Some lung infections require surgical removal of the infected part of the lung. If this is necessary many times, lung function ... Inflammation and infection cause injury and structural changes to the lungs, leading to a variety of symptoms. In the early ...

*Paraburkholderia

Unlike Burkholderia species, Paraburkholderia members are not commonly associated with human infection. Paraburkholderia ... Burkholderia ferrariae Burkholderia fungorum Burkholderia ginsengisoli Burkholderia graminis Burkholderia heleia Burkholderia ... Burkholderia metallica Burkholderia mimosarum Burkholderia monticola Burkholderia nodosa Burkholderia oxyphila Burkholderia ... Burkholderia soli Burkholderia sprentiae Burkholderia susongensis Burkholderia symbiotica Burkholderia terrae Burkholderia ...

*Human herpesvirus 6

... à une infection à Burkholderia cepacia complex chez un nourrisson révélant une granulomatose septique et une intégration ... Primary infections in adults are rare since most occurrences are in children. When the infection does occur for the first time ... Once inside, two outcomes have been described: active and inactive infections. Active infections involve the linear dsDNA ... Lymphohistiocytic activation syndrome and Burkholderia cepacia complex infection in a child revealing chronic granulomatous ...

*Bed Head

The recalled products said to contain Enterobacter gergoviae or Burkholderia cepecia, which at most causes infections if ...

*Burkholderia pseudomallei

B. pseudomallei infection in humans is called melioidosis; its mortality is 20 to 50% even with treatment. The antibiotic of ... October 2005). "Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for ... 2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450. ...

*Burkholderia contaminans

"Burkholderia contaminans: Unusual cause of biliary sepsis". Journal of Infection and Chemotherapy. 19 (5): 969-71. doi:10.1007/ ... Burkholderia contaminans is a gram-negative, bacterium from the genus of Burkholderia and the family of Burkholderiaceae and ... Burkholderia acidipaludis can cause biliary sepsis. "Genus Burkholderia". List of Prokaryotic Names with Standing in ... Ohji, G; Ohkusu, K; Toguchi, A; Otsuka, Y; Hosokawa, N; Iwata, K (Oct 2013). "Burkholderia contaminans: unusual cause of ...

*Burkholderia cenocepacia

A review of B. cenocepacia in respiratory infections of cystic fibrosis patients stated that "one of the most threatening ... "Burkholderia cenocepacia". NCBI Taxonomy Browser. 95486. Type strain of Burkholderia cenocepacia at BacDive - the Bacterial ... Burkholderia cenocepacia is a species of Gram-negative bacteria that is common in the environment, can form a biofilm with ... Burkholderia cenocepacia is a Gram-negative bacterium with the ability to form a biofilm Nida H. Alshraiedeh; Sarah ...

*Superoxide dismutase

During infection, some bacteria (e.g., Burkholderia pseudomallei) therefore produce superoxide dismutase to protect themselves ... "Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei". Microbiology. 157 ( ...

*Burkholderia

... and Burkholderia cepacia, an important pathogen of pulmonary infections in people with cystic fibrosis (CF). The Burkholderia ( ... glathei Burkholderia glumae Burkholderia grimmiae Burkholderia humi Burkholderia lata Burkholderia latens Burkholderia mallei ... Burkholderia ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia cepacia Burkholderia ... Burkholderia cocovenenans Burkholderia contaminans Burkholderia diffusa Burkholderia dolosa Burkholderia gladioli Burkholderia ...

*Burkholderia glumae

Their infection to rice panicles occurs at flowering, if the bacterial population reaches to a threshold level and ... Burkholderia glumae is a Gram-negative soil bacterium. Symptoms of bacterial panicle blight include seedling blighting and ... Newsletter.pdf Type strain of Burkholderia glumae at BacDive - the Bacterial Diversity Metadatabase. ...

*Non-fermenter

... has great relevance in the diagnosis of bacterial infections. Acinetobacter Bordetella Burkholderia Legionella Moraxella ...

*Trimeric autotransporter adhesin

The process of infection is complicated. The invasive bacterium must overcome many barriers in order to infect its host, ... "Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head". PLoS ONE. 5 (9): e12803. doi:10.1371/journal. ... TAAs are just one of many methods bacteria use to infect their hosts, infection resulting in diseases such as pneumonia, sepsis ... found as a common cause of middle ear infections in humans. The structure of UspA1 also has a head domain at N-terminal domain ...
In this study, we compare our results for a G. mellonella infection model with previously published BCC data from other infection models, taking care to use many of the identical BCC strains previously tested in order to ensure valid comparison. We observed that G. mellonella, as an infection model for the BCC, possessed several advantages over other infection models. Using G. mellonella, we obtained similar results to both mouse and other alternative infection models with identical BCC strains. In our experience, no other alternative infection models as tested were as sensitive, accurate (with respect to mice and rat lung model results), or as robust or simple to use as the G. mellonella model. This was despite the fact G. mellonella possesses a relatively complex innate immune response, which is lacking in plant infection models. Furthermore, due to ethical and regulatory issues, it is now difficult to perform LD50 experiments with mice. In addition, amoebae and C. elegans are somewhat more ...
Glowicz J, Crist M, Gould C, Moulton-Meissner H, Noble-Wang J, de Man TJB, Perry KA, Miller Z, Yang WC, Langille S, Ross J, Garcia B, Kim J, Epson E, Black S, Pacilli M, LiPuma JJ, Fagan R, B. cepacia Investigation Workgroup. 2018. A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. Am J Infect Control 46:649-655.. Brooks RB, Mitchell PK, Miller JR, Vasquez AM, Havlicek J, Lee H, Quinn M, Adams E, Baker D, Greeley R, Ross K, Daskalaki I, Walrath J, Moulton-Meissner H, Crist MB, Burkholderia cepacia Workgroup. 2018. Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure to Contaminated Saline Flush Syringes - United States, 2016-2017. Clin Infect Dis Off Publ Infect Dis Soc Am.. Becker SL, Berger FK, Feldner SK, Karliova I, Haber M, Mellmann A, Schäfers H-J, Gärtner B. 2018. Outbreak of Burkholderia cepacia complex infections associated with ...
Cystic fibrosis (CF) is a recessive genetic disease characterized by chronic respiratory infections and inflammation causing permanent lung damage. Recurrent infections are caused by Gram-negative antibiotic-resistant bacterial pathogens such as Pseudomonas aeruginosa, Burkholderia cepacia complex (Bcc) and the emerging pathogen genus Pandoraea. In this study, the interactions between co-colonizing CF pathogens were investigated. Both Pandoraea and Bcc elicited potent pro-inflammatory responses that were significantly greater than Ps. aeruginosa. The original aim was to examine whether combinations of pro-inflammatory pathogens would further exacerbate inflammation. In contrast, when these pathogens were colonized in the presence of Ps. aeruginosa the pro-inflammatory response was significantly decreased. Real-time PCR quantification of bacterial DNA from mixed cultures indicated that Ps. aeruginosa significantly inhibited the growth of Burkholderia multivorans, Burkholderia cenocepacia, Pandoraea
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Pathogenic Burkholderia rely on host factors for efficient intracellular replication and are highly refractory to antibiotic treatment. To identify host genes that are required by Burkholderia spp. during infection, we performed a RNA interference (RNAi) screen of the human kinome and identified 35 host kinases that facilitated Burkholderia thailandensis intracellular survival in human monocytic THP-1 cells. We validated a selection of host kinases using imaging flow cytometry to assess efficiency of B. thailandensis survival in the host upon siRNA-mediated knockdown. We focused on the role of the novel protein kinase C isoform, PKC-η, in Burkholderia infection and characterized PKC-η/MARCKS signaling as a key event that promotes the survival of unopsonized B. thailandensis CDC2721121 within host cells. While infection of lung epithelial cells with unopsonized Gram-negative bacteria stimulated phosphorylation of Ser175/160 in the MARCKS effector domain, siRNA-mediated knockdown of PKC-η ...
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to ...
Nurse Assist voluntarily recalled its I.V. Flush Syringes after becoming aware of patients that developed Burkholderia cepacia bloodstream infections while receiving intravenous care using prepackaged saline flushes from Nurse Assist. Nurse Assist is notifying its distributors and customers via email, phone call, and certified mail. Customers will receive instructions for returning product. For freight collect shipping information, please contact the Customer Service Team at 1-800-649-6800 ext. 10.. Nurse Assist is actively investigating the possible link to the infections with the Food and Drug Administration, the U.S. Centers for Disease Control, and various state health departments to ensure that the products are safe for their intended use. Until an investigation can be completed, Nurse Assist urges all healthcare facilities with affected product to discontinue use and return the product to the supplier.. Consumers with questions may contact the company via telephone at 1-800-649-6800 ext. ...
November 11, 2014 by: Julie Wilson staff writer (NaturalNews) Ten brands of baby wipes produced by the Pennsylvania-based Nutek Disposables, Inc., were recalled on October 25, 2014, following complaints of foul odor and discoloration. Upon further testing, the baby wipe and adult washcloth manufacturer discovered that some of their products contained Burkholderia cepacia, a…
At the beginning of this review it is essential to clarify the terminology that will be used to refer to the members of the Burkholderia cepacia complex and their relatives. The name B. cepacia will relate only to B. cepacia genomovar I. Strains resembling B. cepacia may belong to the B. cepacia complex, to otherBurkholderia species (for instance, Burkholderia gladioli), or to species from other genera (for instance,Ralstonia pickettii) that share some phenotypic or genotypic similarities with the B. cepacia complex. B. cepacia complex bacteria and organisms that may be confused with them will be altogether referred to as B. cepacia-like organisms. Most previous reports regarding these organisms were published before the recognition of the complicated taxonomic relationships between the different members of the B. cepacia complex; it is therefore unclear to what category the presumed B. cepacia isolates described would belong. For that reason, when such literature is cited, the name "B. cepacia" ...
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B. cepacia complex bacteria can form biofilms, not only on abiotic surfaces (e.g., glass and plastics), but also on biotic surfaces such as epithelial cells, leading to the suggestion that biofilm formation plays a key role in persistent infection of cystic fibrosis lungs. This article presents an overview of the molecular mechanisms involved in B. cepacia complex biofilm formation, the increased resistance of sessile B. cepacia complex cells and the role of quorum sensing in B. cepacia complex biofilm formation.
Bacteria of the Burkholderia cepacia complex (Bcc) are pathogens of humans, plants, and animals. Burkholderia cenocepacia is one of the most common Bcc species infecting cystic fibrosis (CF) patients and its carriage is associated with poor prognosis. In this study, we characterized a general O-link …
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function. Because of the resistance of BCC to many antibiotics, treatment options are often limited. New therapies to improve outcomes for patients infected with BCC are needed.. However, because of the unpredictable nature of this pulmonary infection in CF, patients with BCC infection have been excluded from many CF therapeutic trials.. Recent published trials in the United States, Australia, and the United Kingdom have all demonstrated clinical benefits from prolonged administration of azithromycin in CF. In these trials, the vast majority of patients were chronically infected with Pseudomonas aeruginosa.. Patients with BCC were excluded from the US and UK trials, and only four patients with BCC infection were enrolled in the Australian trial. Thus, the effectiveness of azithromycin in CF patients infected with BCC is largely unknown and deserves further ...
ID CP000871; SV 1; circular; genomic DNA; STD; PRO; 167422 BP. XX AC CP000871; AAVB01000000-AAVB01000037; XX PR Project:PRJNA17407; XX DT 16-NOV-2007 (Rel. 93, Created) DT 12-DEC-2013 (Rel. 119, Last updated, Version 2) XX DE Burkholderia multivorans ATCC 17616 plasmid pBMUL01, complete sequence. XX KW . XX OS Burkholderia multivorans ATCC 17616 OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex. OG Plasmid pBMUL01 XX RN [1] RP 1-167422 RG US DOE Joint Genome Institute RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., RA Richardson P.; RT "Complete sequence of plasmid1 of Burkholderia multivorans ATCC 17616"; RL Unpublished. XX RN [2] RP 1-167422 RG US DOE Joint Genome Institute RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., ...
Regan KH, Bhatt J. Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD009876. DOI: 10.1002/14651858.CD009876.pub3 ...
Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective therapeutic treatments are lacking. In this study, we showed that CpG administration increased survival, demonstrating protection in the murine glanders model. Bacterial recovery from infected lungs, liver and spleen was significantly reduced in CpG-treated animals as compared with non-treated mice. Reciprocally, lungs of CpG-treated infected animals were infiltrated with higher levels of neutrophils and inflammatory monocytes, as compared to control animals. Employing the B. mallei bioluminescent strain CSM001 and the Neutrophil-Specific Fluorescent Imaging Agent, bacterial dissemination and neutrophil trafficking were monitored in real-time using multimodal in vivo whole body imaging techniques. CpG-treatment increased recruitment of neutrophils to the lungs and reduced bioluminescent bacteria, correlating with decreased bacterial burden and increased protection against acute
Review question We looked for evidence of which antibiotics are best to treat a flare up of symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection.. Background Cystic fibrosis is a common inherited condition where the lungs often become blocked with mucus. This harms the lungs defences and often results in chronic, persistent infections that cannot be cleared by antibiotics. People with cystic fibrosis often need courses of antibiotics to reduce their symptoms (for instance cough, excess mucus and breathlessness) when these flare up or worsen. Such episodes are called exacerbations, and are usually treated with intravenous antibiotics (given through a drip into a vein). One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. They are ...
Nicholson, Audrey, Perry, John, James, Arthur, Stanforth, Stephen, Carnell, Sonya, Wilkinson, Kathryn, Khan, Anjam, de Soyza, Anthony and Gould, Kate (2012) In vitro activity of S-(3,4-dichlorobenzyl) isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents, 39 (1). pp. 27-32. ISSN 0924-8579 de Soyza, Anthony, Meachery, Gerard, Hester, Katy, Nicholson, Audrey, Parry, Gareth, Tocewicz, Krzysztof, Pillay, Thasee, Clark, Stephen, Lordan, James, Schueler, Stephan, Fisher, Andrew, Dark, John, Gould, Kate and Corris, Paul (2010) Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience. The Journal of Heart and Lung Transplantation, 29 (12). pp. 1395-1404. ISSN 1053 2498 Meachery, Gerard, de Soyza, Anthony, Nicholson, Audrey, Parry, Gareth, Hasan, Asif, Tocewicz, Krzysztof, ...
Review question. We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent.. Background. Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus blocks up their lungs and digestive systems. People with cystic fibrosis suffer from lots of chest infections, which cause scarring of their airways. Eventually, they develop infections that cant be cured with antibiotics, so their lungs always contain lots of bugs, this is described as being chronically infected. One of these bugs, Burkholderia cepacia, causes a lot of problems for people with cystic fibrosis because it is very difficult to treat and makes their lung disease deteriorate faster than it otherwise would. This is an updated version of the review.. Search date. We last searched for any evidence on 12 March 2019.. Study ...
Free Online Library: Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health, general Infection Health aspects
TY - JOUR. T1 - Endemic Burkholderia cepacia bacteraemia. T2 - Clinical features and antimicrobial susceptibilities of isolates. AU - Yu, Wen Liang. AU - Wang, Der Yuan. AU - Lin, Cheng Wen. AU - Tsou, Mei Fen. PY - 1999. Y1 - 1999. N2 - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
Quorum sensing is a mechanism for regulating proteobacterial gene expression in response to changes in cell population. In proteobacteria, N-acyl homoserine lactone (AHL) appears to be the most widely used signalling molecules in mediating, among others, the production of extracellular virulence factors for survival. In this work, the genome of B. cepacia strain GG4, a plasmid-free strain capable of AHL synthesis was explored. In silico analysis of the 6.6 Mb complete genome revealed the presence of a LuxI homologue which correspond to Type I quorum sensing. Here, we report the molecular cloning and characterization of this LuxI homologue, designated as BurI. This 609 bp gene was cloned and overexpressed in Escherichia coli BL21(DE3). The purified protein was approximately 25 kDa and is highly similar to several autoinducer proteins of the LuxI family among Burkholderia species. To verify the AHL synthesis activity of this protein, high resolution liquid chromatography-mass spectrometry analysis
Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, wit...
A polyphasic taxonomic study including DNA-DNA reassociation experiments and an extensive biochemical characterization was performed on 14 Burkholderia isolates from moss gametophytes of nutrient-poor plant communities on the southern Baltic Sea coast in northern Germany. The strains were classified within two novel species, for which the names Burkholderia bryophila sp. nov. and Burkholderia megapolitana sp. nov. are proposed. The former species also includes isolates from grassland and agricultural soil collected in previous studies. Strains Burkholderia bryophila 1S18T (=LMG 23644T =CCUG 52993T) and Burkholderia megapolitana A3T (=LMG 23650T =CCUG 53006T) are the proposed type strains. They were isolated from Sphagnum rubellum and Aulacomnium palustre, respectively, growing in the Ribnitzer Großes Moor nature reserve (Mecklenburg-Pommern, Germany). All moss isolates of both novel species showed antifungal activity against phytopathogens as well as plant-growth-promoting properties.
Burkholderia cepacia lipase (BCL) formerly known as Pseudomonas cepacia lipase has been shown to be a useful enzyme which catalyzes a broad range of different reactions in water and non-polar solvents under mild conditions. BCL is a highly selective catalyst for a broad range of substrates [1], including the kinetic resolution of racemic mixtures of secondary alcohols by hydrolysis in water or esterification in organic solvents [2-4]. All lipases have a similar architecture, the α/β hydrolase fold [5, 6], which consists of parallel β-strands flanked by α-helices, and an active site with a catalytic triad consisting of Ser, His, and Asp/Glu [6, 7]. The characteristic of most lipases is their activation upon binding to a hydrophobic interface [8]. Most lipases consist of a mobile element at the surface, a lid, which covers the active site [9]. The lid is opening at a hydrophobic interface, making the active site accessible for substrates and enhancing the activity of the lipase [10, 11]. ...
Cystic fibrosis center coordinated care - How can cystic fibrosis affect p.I.E.S development? Certainly. Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US. A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications. Emotional & phys. Development depend on severity, time in hospital, complications. Morb. & mort. Factors afect emotional, cognitive behavior.
Cook Childrens Cystic Fibrosis center is nationally accredited by the Cystic Fibrosis Foundation. Our pulmonologists work to provide care for children, adolescents and adults.
The Minnesota Cystic Fibrosis Center treats children, teens and adults with cystic fibrosis and other related lung and respiratory complications
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Lineage: cellular organisms; Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex; Burkholderia ...
Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families. Antarctica is one of the most extraordinary places on Earth and exhibits many distinctive features. Antarctic microorganisms are well known producers of valuable secondary metabolites. Specifically, several Antarctic strains have been reported to inhibit opportunistic human pathogens strains belonging to Burkholderia cepacia complex (Bcc). Herein, we applied a biodiscovery pipeline for the identification of anti-Bcc compounds. Antarctic sub-sea sediments were collected from the Ross Sea, and used to isolate 25 microorganisms, which were phylogenetically affiliated to three bacterial genera (Psychrobacter, Arthrobacter, and Pseudomonas) via sequencing and analysis of 16S rRNA genes. They were then subjected to a primary cell-based screening to determine their bioactivity against Bcc strains. Positive isolates were used to produce crude extracts from microbial
Please Note: Ortholuge cannot be used for certain RBB analyses involving closely-related strains (e.g. Burkholderia cenocepacia J2315 versus Burkholderia cenocepacia AU 1054) because the phylogenetic distance between each ingroup protein is very small in relation to the phylogenetic distance between each ingroup protein and the associated outgroup protein. In these cases, the "Ortholuge Classification" value will be left blank which indicates Ortholuge analysis was not peformed, however the two proteins may very well be orthologs. In other cases, only some rows will be missing Ortholuge classifications, which can occur when a suitable gene could not be found in the outgroup species ...
The advantages of MALDI-TOF are that identification from pure culture can take minutes and is relatively cost-effective- other than the cost of the machine (approx. $200,000), relatively few reagents are required to process a sample. A recent paper investigating the use of MALDI-TOF to identify common CF pathogens, estimated that 71% of Pseudomonas aeruginosa isolates were identified by MALDI-TOF by day 2 of incubation, at which stage none had been identified by conventional culture2. Similarly, with Staphylococcus aureus, 89% were identified using MALDI-TOF by day 1 of incubation, whereas only 68% had been identified by culture on day 2. It can also identify bacteria which are slow growing much more quickly than by using standard culture techniques. In addition, it can also be used to identify yeasts and fungi, which are commonly found in CF patients. It can also determine differences between species of bacteria, such as those in the Burkholderia cepacia complex, which prove problematic for ...
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In the past 2 decades, Burkholderia cepacia has emerged as a human pathogen causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. One highly transmissible strain has spread across North America and Britain, and another between ...
Insight Pharmaceuticals, LLC, has recalled the nasal spray Nostrilla Nasal Decongestant due to potential contamination with Burkholderia cepacia, according to an FDA MedWatch safety alert.
Ah, yes! Im dealing with Burkholderia. 16s rDNA analyses showed similarity to B. cepacia and B. cenocepacia. Perhaps the fact that B. cepacia exists as a complex of many strains (genomovars) that makes biochemical identification inaccurate; what more when I did it the conventional way. Hoping this time that the commercial kit like API could back the 16s analyses up.. ...
Temocillin. Molecular model of the drug temocillin (C16.H18.N2.O7.S2), a beta-lactamase-resistant penicillin used to treat multiresistant Gram-negative bacterial infections. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue), oxygen (red) and sulphur (yellow). Illustration. - Stock Image F017/0687
Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the penA gene, which encodes the inducible penicillinase of B. cepacia, and show that it belongs to the molecular class A beta-lactamases and exhibits a high degree of similarity to the chromosomal beta-lactamase of Klebsiella oxytoca. Analysis of the nucleotide sequence of the DNA region directly upstream of the penA coding sequence revealed an open reading frame (penR), the transcription of which was oriented opposite to that of penA and whose initiation was 130 bp away from that of penA. Two potential ribosome-binding sites and two overlapping -10 and -35 promoter sequences were identified in the intercistronic region. The predicted translation product of penR was a polypeptide of 301 ...
The aim of this project was to investigate novel antimicrobial strategies against B. cepacia, based on natural antimicrobial compounds present in plants and human airways as protection against bacterial disease. The project focused on a panel of 20 strains of B. cepacia complex. Isolates included strains representing major epidemic clones of B. cepacia and exhibiting a range of susceptibilities to all classes of conventional antibiotics. The project is focused on two major themes. First, a study of antimicrobials from plants and second, examination of the antimicrobial activities of cationic peptides present in human airway secretions. The susceptibility of the B. cepacia strain panel to plant extracts was investigated, in particular the activity of aqueous garlic extract (AGE) and thyme oil. The MIC of thyme oil for all 20 strains was found to be 0.01%. MICs of AGE ranged from 0.25%-3%. Killing curves suggesting that AGE produces a slow killing effect over a twenty four hour period, whereas ...
Cyclists from Middlesbrough Erimus Rotary Club rode 110 miles to help the Teesside Cystic Fibrosis Centre, based at The James Cook University Hospital
SWISS-MODEL Repository entry for A0K321 (GCSP_BURCH), Glycine dehydrogenase (decarboxylating). Burkholderia cenocepacia (strain HI2424)
The species that presently constitute the Burkholderia cepacia complex (Bcc) have multiple roles; they include soil and water saprophytes, bioremediators, and plant, animal and human pathogens. Since the first description of pathogenicity in the Bcc was based on sour skin rot of onion bulbs, this study returned to this plant host to investigate the onion-associated phenotype of the Bcc. Many Bcc isolates, which were previously considered to be non-mucoid, produced copious amounts of exopolysaccharide (EPS) when onion tissue was provided as the sole nutrient. EPS production was not species-specific, was observed in isolates from both clinical and environmental sources, and did not correlate with the ability to cause maceration of onion tissue. Chemical analysis suggested that the onion components responsible for EPS induction were primarily the carbohydrates sucrose, fructose and fructans. Additional sugars were investigated, and all alcohol sugars tested were able to induce EPS production, in ...
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The CF Center entrance is located in the Bernstein Pavilion between 15th and 16th Streets, facing Second Avenue. We are easily accessible by car and by public transportation.
CUBRC, Inc. two weeks ago announced that CUBRCs Biological and Medical Sciences team, in collaboration with EpiVax, Inc., has received a four-year grant worth $1.87 million from the Defense Threat Reduction Agency (DTRA) within the Department of Defense (DoD). CUBRC, EpiVax, and scientists at the University of Florida will be investigating immune cells from patients that were previously infected with Burkholderiapseudomallei to understand how this bacterium evades the human immune system and use that information to engineer an effective vaccine. CUBRCs president and CEO, Tom McMahon, stated, "We are truly thankful for DTRAs confidence in our proposal to research vaccine antigens for prevention of Burkholderia pseudomallei infections, an important pathogen of biothreat potential.". CUBRC says it will leverage its technical expertise in biomedical R&D and its experience leading large federal government grants and contracts in collaboration with EpiVax and the University of Florida to execute ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A University of Queensland-led international study has discovered a new type of bacterial structure which has previously only been seen in more complex cells. Research team leader UQ School of Chemistry and Molecular Biosciences microbiologist Emeritus Professor John Fuerst said the study had found pore-like structures in a bacterium called Gemmata obscuriglobus.
Development and validation of |i|Burkholderia pseudomallei|/i|-specific real-time PCR assays for clinical, environmental or forensic detection applications
Patients, Antibiotics, Bacteria, Biofilm, Biofilms, Cystic Fibrosis, Fibrosis, Sputum, Adults, Asthma, Death, Lung, Azithromycin, Burkholderia, Burkholderia Cepacia, Pseudomonas, Pseudomonas Aeruginosa, Rifampin, Treatment, Algorithm
As Western North Carolinas Cystic Fibrosis center, we are here to provide care to children from birth to 18 years. Visit one of our locations to learn more
Today we went to the Cystic Fibrosis Center for Laineys 3rd visit. Since this time last month Lainey has grown 1/2 inch and gained 1 1/2 pounds. She is now 23 1/2 inches long and 10 lbs. 15.9 oz! Still not the 3 lbs. they had wanted to see (she is still in the 10th percentile for weight), but we are working on that. Due to the frequency and consistancy of her bowel movements, it has been concluded that changes with her enzymes need to be made if we wish to see an increase in weight. To assist in weight gain, Dr. Caplan decided to try upping her enzymes to 2 per meal and taken in applesauce. Originally we tried the applesauce, but it was way too difficult to feed it to a newborn. Now she is loving the addition of applesauce and doesnt seem to mind the new requirement! The thoughts behind the applesauce are that the enzymes will make it to the small intestine before the formula. This is important because the enzymes aid in digestion, fat and vitiamin absorption, and in the end ~ weight gain. If ...
Survival curves for D. melanogaster infected with B. cenocepacia strains.Pricking assays were performed with a minimum of 30 flies for each strain. Statistical
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The incidence of non-cystic fibrosis bronchiectasis is increasing in Germany, so a better understanding of its economic burden is needed, a study suggests.
Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in cystic fibrosis and other immunocompromised patients. The bacterium survives within macrophages by interfering with typical endocytic trafficking, resulting in delayed maturation of a B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia alters gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation. Furthermore, we hypothesize that specialized bacterial secretion systems are involved in the interactions between intracellular bacteria and macrophages. In this work, we characterize later-stage infection of macrophages by B. cenocepacia, showing replication within an acidified endosomal compartment suggestive of a phagolysosome. We examine differential gene expression by intracellular B. cenocepacia using selective capture of transcribed sequences (SCOTS) with both competitive enrichment and microarray analysis. We identified 766
Members of the Burkholderia cepacia complex (Bcc), such as B. ambifaria, are effective biocontrol strains, for instance, as plant growth-promoting bacteria; however, Bcc isolates can also cause severe respiratory infections in people suffering from cystic fibrosis (CF). No distinction is known between isolates from environmental and human origins, suggesting that the natural environment is a potential source of infectious Bcc species. While investigating the presence and role of phase variation in B. ambifaria HSJ1, an isolate recovered from a CF patient, we identified stable variants that arose spontaneously irrespective of the culture conditions. Phenotypic and proteomic approaches revealed that the transition from wild-type to variant types affects the expression of several putative virulence factors. By using four different infection models (Drosophila melanogaster, Galleria mellonella, macrophages and Dictyostelium discoideum), we showed that the wild-type was more virulent than the ...
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.
TY - JOUR. T1 - Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex. AU - Loveridge, E Joel. AU - Jones, Cerith. AU - Bull, Matthew J. AU - Moody, Suzy C. AU - Kahl, Małgorzata W. AU - Khan, Zainab. AU - Neilson, Louis. AU - Tomeva, Marina. AU - Adams, Sarah E. AU - Wood, Andrew C. AU - Rodriguez-Martin, Daniel. AU - Pinel, Ingrid. AU - Parkhill, Julian. AU - Mahenthiralingam, Eshwar. AU - Crosby, John. N1 - Copyright © 2017 Loveridge et al.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Pseudomonas mesoacidophila ATCC 31433 is a Gram-negative bacterium, first isolated from Japanese soil samples, that produces the monobactam isosulfazecin and the β-lactam-potentiating bulgecins. To characterize the biosynthetic potential of P. mesoacidophila ATCC 31433, its complete genome was determined using single-molecule real-time DNA sequence analysis. The 7.8-Mb genome comprised four replicons, three chromosomal (each ...
The overall goal of this project is to forensically characterize 100 unknown Burkholderia isolates in the US-Australia collaboration. We will identify genome-wide single nucleotide polymorphisms (SNPs) from B. pseudomallei and near neighbor species including B. mallei, B. thailandensis and B. oklahomensis. We will design microarray probes to detect these SNP markers and analyze 100 Burkholderia genomic DNAs extracted from environmental, clinical and near neighbor isolates from Australian collaborators on the Burkholderia SNP microarray. We will analyze the microarray genotyping results to characterize the genetic diversity of these new isolates and triage the samples for whole genome sequencing. In this interim report, we described the SNP analysis and the microarray probe design for the Burkholderia SNP microarray. ...
Caenorhabditis elegans has been used as a host for the study of bacteria that cause disease in mammals. However, a significant limitation of the model is that C elegans is not viable at 37 degrees C. We report that the gonochoristic nematode Panagrellus redivivus survives at 37 degrees C and maintains its life cycle at temperatures up to and including 31.5 degrees C. The C elegans pathogens Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, but not Yersinia pseudo tuberculosis, reduced P. redivivus lifespan. Of four strains of Burkholderia multivorans tested, one reduced P. redivivus lifespan at both temperatures, one was avirulent at both temperatures and two strains reduced P. redivivus lifespan only at 37 degrees C. The mechanism by which one of these strains killed P. redivivus at 37 degrees C, but not at 25 degrees C, was investigated further. Killing required viable bacteria, did not involve bacterial invasion of tissues, is unlikely to be due to a diffusible, bacterial ...
TY - JOUR. T1 - Epidemiological tracking and population assignment of the non-clonal bacterium, burkholderia pseudomallei. AU - Dale, Julia. AU - Price, Erin P.. AU - Hornstra, Heidie. AU - Busch, Joseph D.. AU - Mayo, Mark. AU - Godoy, Daniel. AU - Wuthiekanun, Vanaporn. AU - Baker, Anthony. AU - Foster, Jeffrey T. AU - Wagner, David M. AU - Tuanyok, Apichai. AU - Warner, Jeffrey. AU - Spratt, Brian G.. AU - Peacock, Sharon J.. AU - Currie, Bart J.. AU - Keim, Paul S. AU - Pearson, Talima R. PY - 2011/12. Y1 - 2011/12. N2 - Rapid assignment of bacterial pathogens into predefined populations is an important first step for epidemiological tracking. For clonal species, a single allele can theoretically define a population. For non-clonal species such as Burkholderia pseudomallei, however, shared allelic states between distantly related isolates make it more difficult to identify population defining characteristics. Two distinct B. pseudomallei populations have been previously identified using ...
Easton A, Haque https://www.ncbi.nlm.nih.gov/pubmed/?term=19829050%5Bpmid%5DA, Chu K, Lukaszewski R, Bancroft GJ. 2007. A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. J Infect Dis 195: 99-107. A Critical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei. ...
The Priebe Laboratory, located in the Enders Research Building of Boston Childrens Hospital, studies the bacterial pathogens Pseudomonas aeruginosa and the Burkholderia cepacia complex, with the long-term goal of developing vaccines and new antimicrobials. Techniques used in Priebes group span multiple fields, including microbiology, molecular biology, genomics, cellular and molecular immunology, and animal models of infection.. ...
Background Burkholderia pseudomallei is the causative agent of melioidosis, a disease of significant morbidity and mortality in both human and animals in endemic areas. There is no vaccine towards the bacterium available in the market, and the efficacy of many of the bacteriums surface and secreted proteins are currently being evaluated as vaccine candidates. Methodology/Principal Findings With the availability of the B. pseudomallei whole genome sequence, we undertook to identify genes encoding the known immunogenic outer membrane protein A (OmpA). Twelve OmpA domains were identified and ORFs containing these domains were fully annotated. Of the 12 ORFs, two of these OmpAs, Omp3 and Omp7, were successfully cloned, expressed as soluble protein and purified. Both proteins were recognised by antibodies in melioidosis patients sera by Western blot analysis. Purified soluble fractions of Omp3 and Omp7 were assessed for their ability to protect BALB/c mice against B. pseudomallei infection. Mice were
1CI8: EstB from Burkholderia gladioli: a novel esterase with a beta-lactamase fold reveals steric factors to discriminate between esterolytic and beta-lactam cleaving activity
Accepted name: 2-hydroxy-1,4-benzoquinone reductase. Reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+. For diagram of reaction click here.. Glossary: hydroxyquinol = 1,2,4-trihydroxybenzene. Other name(s): hydroxybenzoquinone reductase; 1,2,4-trihydroxybenzene:NAD oxidoreductase; NADH:2-hydroxy-1,4-benzoquinone oxidoreductase. Systematic name: NADH:2-hydroxy-1,4-benzoquinone oxidoreductase. Comments: A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 214466-94-1. References:. 1. Zaborina, O., Daubaras, D.L., Zago, A., Xun, L., Saido, K., Klem,T., Nikolic, D. and Chakrabarty, A.M. Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100. J. Bacteriol. 180 (1998) 4667-4675. [PMID: 9721310]. ...
Burkholderia pseudomallei is a human and animal pathogen in tropical regions, especially Southeast Asia and northern Australia. Currently little is known about the genetics and molecular biology of this organism. In this report, we describe the mutagenesis of B. pseudomallei with the transposon Tn5-OT182. B. pseudomallei 1026b transposon mutants were obtained at a frequency of 4.6 x 10(-4) per initial donor cell, and the transposon inserted randomly into the chromosome. We used Tn5-OT182 to identify the flagellin structural gene, fliC. We screened 3,500 transposon mutants and identified 28 motility mutants. Tn5-OT182 integrated into 19 unique genetic loci encoding proteins with homology to Escherichia coli and Salmonella typhimurium flagellar and chemotaxis proteins. Two mutants, MM35 and MM36, contained Tn5-OT182 integrations in fliC. We cloned and sequenced fliC and used it to complement MM35 and MM36 in trans. The fliC transcriptional start site and a sigmaF-like promoter were identified by ...
Burkholderia pseudomallei is resistant to a diverse group of antimicrobials including third generation cephalosporins whilst quinolones and aminoglycosides have no reliable effect. As therapeutic options are limited, development of more effective forms of immunotherapy is vital to avoid a fatal outcome. In an earlier study, we reported on the B. pseudomallei serine MprA protease which is relatively stable over a wide pH and temperature range and digests physiological proteins. The present study was carried out to evaluate the immunogenicity and protective efficacy of the MprA as a potential vaccine candidate. In BALB/c mice immunized with recombinant MprA protease (smBpF4), a significantly high IgG titer was detectable. Isotyping studies revealed that the smBpF4-specific antibodies produced were predominantly IgG1, proposing that immunization with smBpF4 triggered a Th2 immune response. Mice were immunized with smBpF4 and subsequently challenged with B. pseudomallei via the intraperitoneal route. Whilst
The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis. Melioidosis has the potential to pose a severe threat to public health and safety. In the United States, Bp is listed as a Tier-1 select agent by the Centers for Disease Control and Prevention (CDC), thus requiring high levels of regulation and biosafety level 3 (BSL3) facilities for experimental manipulation of live organisms. An avirulent ∆purM derivative of strain 1026b (Bp82) has proven to be a valuable tool for biosafe research as a select-agent excluded strain, but the high level of genetic diversity between Bp strains necessitates an expansion of the biosafe toolset. The ∆purM mutation was recapitulated in the Bp 576a strain, a serotype B background. An important difference between strains 1026b and 576a is the lipopolysaccharide (LPS), a major virulence factor and protective antigen. Polyclonal sera from 1026b-challenged non-human
Search for abbreviations and long forms in lifescience, results along with the related PubMed / MEDLINE information and co-occurring abbreviations.
Scientists may have found a way to kill Burkholderia cenocepacia, a multi-drug resistant plant pathogen that causes severe infections in people with cystic fibrosis.. The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics. Researchers hope to discover novel molecules as antibiotic candidates which could disrupt the synthesis of Ara4N.. ...
4B6Z: High-Resolution Structure of the M14-Type Cytosolic Carboxypeptidase from Burkholderia Cenocepacia Refined Exploiting Pdb_Redo Strategies.
HRCT defined non-CF bronchiectasis is not an uncommon problem in our referral population. The 93 cases described constitute 9.6% of all new referrals to a tertiary respiratory paediatric referral centre over a period of 5.5 years, which represents a 10-fold higher rate of diagnosis than that described by Nikolaizik and Warner in 1994.11 This increase can largely be attributed to the introduction of HRCT scanning to investigate chronic respiratory illness in children in recent years. A crude estimate of the prevalence of HRCT defined non-CF bronchiectasis in children under 17 years of age in the Northern Region (excluding South Cleveland) is one in 5800 based on the average annual birth rate of 31 500. It is acknowledged that this will include children at the milder end of the disease spectrum, as a single dilated bronchus of cross sectional diameter greater than that of its accompanying pulmonary artery is sufficient to satisfy the diagnostic criteria for HRCT bronchiectasis. It is anticipated, ...
We have reported the largest randomised controlled trial of a mucoactive therapy in non-CF bronchiectasis to date. We found that the annual exacerbation rate was reduced in both the high dose (400 mg twice daily) and low dose (50 mg twice daily) control arms during the course of the study, although there was no difference in annual exacerbation rate between the two arms. However, inhaled mannitol at a dose of 400 mg twice daily significantly extended the time to first exacerbation, increased the proportion of patients who remained exacerbation free, reduced the number of days of antibiotic therapy and improved quality of life.. Although the study cohort was intentionally enriched for a subset of adults with bronchiectasis having a significant impact on their lives, including having at least two exacerbations in the previous 12 months, a minimum SGRQ score of 30, producing at least 10 grams of sputum a day and an FEV1 ,85% predicted, the population studied is arguably representative of many ...
All Childrens Hospital (ACH) is a Cystic Fibrosis Foundation accredited care Center. Caring for more than 170 pediatric patients the Cystic Fibrosis Center provides comprehensive services, ranging from evaluation and diagnosis to treatment and education.
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Melioidosis is diagnosed by isolating Burkholderia pseudomallei from blood, urine, sputum, skin lesions, or abscesses; or by detecting an antibody response to the bacteria.
Among patients with the lung disorder non-cystic fibrosis bronchiectasis, treatment with the antibiotic azithromycin resulted in improvement in symptoms but also increased the risk of antibiotic resistance, according to a ...
The prevalence of bronchiectasis varies with time period and geography, due to differences in antibiotic prescription, availability of vaccinations, and prevalence of associated disorders. Additionally, the doctors alertness for bronchiectasis and the availability of sensitive diagnostic tools may affect reported prevalence. In the United States the prevalence of non-cystic fibrosis bronchiectasis among adults between 1999 and 2001 was estimated to be 51 per 100 000 population.3 The prevalence was higher among women than men (71 v 32 per 100 000) and increased markedly with age (4 per 100 000 for people aged 18-34 years v 272 per 100 000 for those aged 75 or … ...
Acclimation, Cold, Plant, Temperatures, Bacteria, Burkholderia, Gene, Growth, Plants, Temperature, Fructose, Mannose, Metabolism, Starch, Water, Gene Expression, Mold, Time, Tissues, Affects
TY - JOUR. T1 - Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis. AU - De Soyza, Anthony. AU - Aksamit, Timothy. PY - 2016/8/2. Y1 - 2016/8/2. N2 - Introduction: Non-cystic fibrosis bronchiectasis (NCFB) is an increasingly prevalent chronic respiratory disease, characterized by a cycle of infection and inflammation. It is progressive and associated with poor quality of life, increasing healthcare costs and mortality. Inhaled antibiotics offer the potential to decrease long-term bacterial burden and reduce or delay exacerbations which are a key driver of disease progression and healthcare costs. Currently however, no inhaled treatments are approved for the prevention of exacerbations in patients with NCFB. Areas covered: We consider current evidence for inhaled treatment in NCFB and discuss ciprofloxacin dry powder for inhalation (DPI), a novel treatment using PulmoSphere™ technology, delivered via a pocket-sized, breath-actuated inhaler. We also detail the unique ...
Appl Environ Microbiol 68: 173-180. Wang H, Marjomaki Book, Ovod Deal, Kulomaa MS( 2002) Numic purification of part iron in Sphingobium Palace ATCC 39723. Biochem Biophys Res Commun 299: 703-709. Nakamura haben, Motoyama file, Hirono S, Yamaguchi I( 2004) Identification, 4:00PM, and Fourth agriculture of inorganic book survey. Biochim Biophys Acta 1700: 151-159. Martin-Le Garrec G, Artaud I, Capeillere-Blandin C( 2001) war and ineffective pictures of the importance body from Burkholderia cepacia interpretation AC1100. Biochim Biophys Acta 1547: 288-301. Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun LY, Kang C( 2010) Characterization of Chlorophenol 4-Monooxygenase( TftD) and NADH: capitalism Oxidoreductase( TftC) of Burkholderia cepacia AC1100. Gisi MR, Xun LY( 2003) Characterization of chlorophenol 4-monooxygenase( TftD) and NADH: download Efectos del cambio climático en las costas de Chile 2009 deterioration physiology distress( TftC) of Burkholderia cepacia AC1100. ...
Results During the 3-year study period, B. gladioli was isolated from blood cultures of 14 patients (3.7 per 1000 admissions). Five out of 14 (35.7%) cases have a positive blood culture at the time of initial admission. Primary diagnoses of neonates were severe major congenital anomalies, congenital leukemia, prematurity with respiratory distress syndrome, pneumonia and parapneumonic pleural effusion. Eleven of the 14 patients (78.6%) had undergone at least one invasive procedure and 71.4% of the patients had undergone two or more of invasive procedures. The most susceptible antimicrobial agents were amikacin, gentamicin, imipenem, ciprofloxacin, trimethoprime/sulphametaxazole and ceftriaxone. The overall in-hospital mortality rate was 21.4%.The mortality rate was 7% for B. gladioli infections.. ...
Citation. Tumapa, S., Holden, M. T., Vesaratchavest, M., Wuthiekanun, V., Limmathurotsakul, D., Chierakul, W., Feil, E. J., Currie, B. J., Day, N. P., Nierman, W. C., Peacock, S. J.. Burkholderia pseudomallei Genome Plasticity Associated With Genomic Island Variation. BMC Genomics. 2008 Apr 25; 9(1): 190.. PubMed Citation. Abstract. ABSTRACT: BACKGROUND: Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an important determinant of virulence potential. The genome contains genomic island (GI) regions that encode a broad array of functions. Although there is some evidence for the variable distribution of genomic islands in B. pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival. RESULTS: Five islands from B. pseudomallei strain K96243 were chosen as representatives of ...
The phenylacetic acid (PA) degradative pathway is the central pathway by which complex aromatic compounds (e.g. styrene) get degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA, which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made a link in Burkholderia cenocepacia between phenylacetic acid (PA) degradation and virulence by showing that insertional mutagenesis of paaA and paaE results in PA-conditional growth and an attenuated killing phenotype in the Caenorhabditis elegans model of infection. Insertional mutagenesis of paaK1, which encodes a phenylacetyl-CoA ligase, did not result in a PA-conditional growth probably due to the presence of a second similar gene (paaK2) encoding another phenylacetyl-CoA ligase (PaaK2). Recently published crystallographic and enzyme kinetics studies comparing the two ligases show that PaaK1 is better able to bind hydroxylated PA derived molecules such as 3-hydroxyphenylacetic (3-OHPA) acid and
Looking for online definition of Pseudomonas gladioli in the Medical Dictionary? Pseudomonas gladioli explanation free. What is Pseudomonas gladioli? Meaning of Pseudomonas gladioli medical term. What does Pseudomonas gladioli mean?
Burkholderia multivorans strain LMG17588 histidinol-phosphate aminotransferase (hisC) gene, partial cds; imidazole glycerol phosphate dehydratase (hisB), multiple antibiotic resistance-related protein (marC), imidazole glycerol phosphate synthase glutamine amidotransferase subunit (hisH), phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA), imidazole glycerol phosphate synthase subunit (hisF), phosphoribosyl-AMP cyclohydrolase (hisI), and phosphoribosyl-ATP pyrophosphohydrolase (hisE) genes, complete cds; and membrane protein gene, partial ...
Glanders is a serious zoonotic disease that primarily affects equids (horses, mules and donkeys). A disease eradication programme based on case detection and destruction of infected domestic animals has been highly successful and the number of reported glanders cases in animals worldwide is now very low. Human glanders is extremely rare and associated with occupations associated with extensive contact with equids. Glanders is caused by Burkholderia mallei, a Gram-negative, non-motile, facultative intracellular organism that is an obligate parasite of equids with no other known natural reservoir. B. mallei is transmitted by direct contact with infected animals, or indirectly via communal food and water sources that have become contaminated by an infected animal. The clinical presentation in equids can be acute or chronic and has been categorized into nasal, pulmonary and cutaneous forms. Diagnosis is based on culturing B. mallei from lesions or exudates and skin or serological testing. Infected ...

New Insights Into Burkholderia Pseudomallei Infection (melioidosis)New Insights Into Burkholderia Pseudomallei Infection (melioidosis)

Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by ... New insights into Burkholderia pseudomallei infection (melioidosis). International Congress on Bacteriology & Infectious ... with a special interest Burkholderia pseudomallei and Salmonella typhi infection and the role of diabetes as well as the gut ... Melioidosis caused by the environmental gram-negative bacillus Burkholderia pseudomallei, is classically characterized by ...
more infohttps://www.omicsonline.org/proceedings/new-insights-into-burkholderia-pseudomallei-infection-melioidosis-15243.html

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus) - ONAGlanders (Farcy, Burkholderia mallei infection, equinia, malleus) - ONA

Burkholderia malleli is able to cause two forms of human infection. Farcy is a subcutaneous form of the bacterial infection ... Best Approach to Infection and Tumor Treatment: Contain or Eliminate?. *Study Identifies Factors Associated With Infection- ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ...
more infohttps://www.oncologynurseadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587915/

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei | SoligenixA critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei | Soligenix

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. J Infect Dis 195: 99- ... A Critical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei ... A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. ...
more infohttps://www.soligenix.com/resource/a-critical-role-for-neutrophils-in-resistance-to-experimental-infection-with-burkholderia-pseudomallei/

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus) - Cancer Therapy AdvisorGlanders (Farcy, Burkholderia mallei infection, equinia, malleus) - Cancer Therapy Advisor

Burkholderia malleli is able to cause two forms of human infection. Farcy is a subcutaneous form of the bacterial infection ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
more infohttp://www.cancertherapyadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587913/

Within-host evolution of Burkholderia pseudomallei during chronic infection of seven Australasian cystic fibrosis patients - UQ...Within-host evolution of Burkholderia pseudomallei during chronic infection of seven Australasian cystic fibrosis patients - UQ...

CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia ... CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia ... Within-host evolution of Burkholderia pseudomallei during chronic infection of seven Australasian cystic fibrosis patients. ... Within-host evolution of Burkholderia pseudomallei during chronic infection of seven Australasian cystic fibrosis patients ...
more infohttps://espace.library.uq.edu.au/view/UQ:564848

Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification. - MORU Tropical Health...Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification. - MORU Tropical Health...

Ceftazidime is the antibiotic of choice for treatment of Burkholderia pseudomallei infections (melioidosis). The chromosomally ... Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis * Community engagement for the ... Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei ... Ceftazidime is the antibiotic of choice for treatment of Burkholderia pseudomallei infections (melioidosis). The chromosomally ...
more infohttps://www.tropmedres.ac/publications/963813/

PKC-η-MARCKS Signaling Promotes Intracellular Survival of Unopsonized Burkholderia thailandensis (Journal Article) | DOE PAGESPKC-η-MARCKS Signaling Promotes Intracellular Survival of Unopsonized Burkholderia thailandensis (Journal Article) | DOE PAGES

59 BASIC BIOLOGICAL SCIENCES; Biological Science; Burkholderia; infection; RNA interference; autophagy; intracellular bacteria ... We focused on the role of the novel protein kinase C isoform, PKC-η, in Burkholderia infection and characterized PKC-η/MARCKS ... To identify host genes that are required by Burkholderia spp. during infection, we performed a RNA interference (RNAi) screen ... As a result, identification of host kinases that are targeted by Burkholderia during infection provides valuable molecular ...
more infohttps://www.osti.gov/pages/biblio/1398907-pkc-marcks-signaling-promotes-intracellular-survival-unopsonized-burkholderia-thailandensis

References « Emerging and Exotic Diseases of Animals Textbook « CFSPHReferences « Emerging and Exotic Diseases of Animals Textbook « CFSPH

Serodiagnosis of Burkholderia mallei infections in horses: state-of-the-art and perspectives. J Vet Med B Infect Dis Vet Public ... Detection and differentiation of Burkholderia pseudomallei, Burkholderia mallei and Burkholderia thailandensis by multiplex PCR ... Infection Control * Infection Control Page. • Cattle Facilities. • Equine Facilities. • Poultry Facilities. • Swine Facilities ... Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. J ...
more infohttp://www.cfsph.iastate.edu/EEDATextbookReferences/index.php?section=glanders

Scientific Articles - The International Burkholderia cepacia Working GroupScientific Articles - The International Burkholderia cepacia Working Group

Burkholderia cepacia Workgroup. 2018. Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure ... Burkholderia cepacia complex infections: More complex than the bacterium name suggest. J Infect 77:166-170. Link to the article ... An Outbreak of Burkholderia cepacia Complex Infections Associated with Contaminated Liquid Docusate. Infect Control Hosp ... Outbreak of Burkholderia cepacia complex infections associated with contaminated octenidine mouthwash solution, Germany, August ...
more infohttps://ibcwg.org/index.php/home/publications/

Burkholderia pseudomallei - WikipediaBurkholderia pseudomallei - Wikipedia

B. pseudomallei infection in humans is called melioidosis; its mortality is 20 to 50% even with treatment. The antibiotic of ... October 2005). "Comparison of Ashdowns medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for ... 2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450. ...
more infohttps://en.wikipedia.org/wiki/Burkholderia_pseudomallei

The American Journal of Tropical Medicine and Hygiene | Clinical, Bacteriologic, and Geographic Stratification of Melioidosis...The American Journal of Tropical Medicine and Hygiene | Clinical, Bacteriologic, and Geographic Stratification of Melioidosis...

... and infection phenotype; ST1137/unifocal bacteremic infection (χ2 = 3.86, P , 0.05), ST1136/multifocal infection without ... The additional 76 cases of laboratory-confirmed melioidosis confirmed additional associations between Burkholderia pseudomallei ... ST1137 infections were predominantly seen in the Western Province, whereas ST1132, 1135, and 1136 infections predominated in ... bacteremia (χ2 = 15.8, P , 0.001), and ST1132/unifocal nonbacteremic infection (χ2 = 6.34, P = 0.02). ...
more infohttp://ajtmh.org/content/journals/10.4269/ajtmh.17-0441

Psychology of Medicine: GlandersPsychology of Medicine: Glanders

It is caused by infection with the bacterium Burkholderia mallei, usually by ingestion of contaminated food or water. Signs of ... Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is ... Infection with either of these bacteria presents with nonspecific symptoms and can be either acute or chronic, impeding rapid ... Attempts have been made to develop vaccines for these infections, which would not only benefit military personnel, a group most ...
more infohttp://monsterologist.blogspot.com/2014/12/glanders.html

Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia. - CDU...Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia. - CDU...

Interestingly, these SNPs appeared after infection and under selection from CAZ chemotherapy. Through heterologous cloning and ... Burkholderia pseudomallei is a Gram-negative bacterium that causes the serious human disease, melioidosis. There is no vaccine ... Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia.. ... Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia. ...
more infohttp://espace.cdu.edu.au/view/cdu:38446

Pathogens | Free Full-Text | Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging TechniquesPathogens | Free Full-Text | Monitoring Therapeutic Treatments against Burkholderia Infections Using Imaging Techniques

Our results indicate that protection of CpG-treated animals was associated with recruitment of neutrophils prior to infection ... Burkholderia mallei, the etiologic agent of glanders, are Category B select agents with biothreat potential, and yet effective ... methods to monitor disease progression and to evaluate the efficacy of therapeutic treatment during bacterial infections. ... Keywords: Burkholderia mallei; CpG; immunomodulation; in vivo imaging; infrared fluorescent imaging Burkholderia mallei; CpG; ...
more infohttp://mdpi.com/2076-0817/2/2/383/xml

Burkholderia infection - causes, side effects and treatments at NaturalPedia.comBurkholderia infection - causes, side effects and treatments at NaturalPedia.com

Burkholderia infection is caused by the Burkholderia cepacia bacteria. B. cepacia is an aerobic gram-negative bacillus native ... Known side effects of Burkholderia infection. The known side effects of Burkholderia infection are similar to the symptoms ... Burkholderia infection is caused by the Burkholderia cepacia bacteria. B. cepacia is an aerobic gram-negative bacillus native ... Zinc can help fight off infections.. Treatments, management plans for Burkholderia infection. B. cepacia can be resistant to a ...
more infohttps://naturalpedia.com/burkholderia-infection-causes-side-effects-and-treatments-at-naturalpedia-com.html

Burkholderia Infections Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2018-2026Burkholderia Infections Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2018-2026

Burkholderia Infections Market report categorizes the global market by drug type, distribution channel, and geography - Global ... Burkholderia infections also cause complications such as soft tissue infections, urinary tract infection and surgical wound ... Burkholderia infections are caused by Burkholderia cepacia. It is a gram negative bacillus found in aquatic environment. It is ... Burkholderia infection symptom can vary widely in people, ranging from no symptoms to serious respiratory infection. Based on ...
more infohttps://www.coherentmarketinsights.com/ongoing-insight/burkholderia-infections-market-153

Multistate Outbreak of Burkholderia cepacia Infections Associated with Oral Liquid Docusate Sodium 
 | HAI | CDCMultistate Outbreak of Burkholderia cepacia Infections Associated with Oral Liquid Docusate Sodium | HAI | CDC

... and numerous healthcare facilities to investigate a multi-state outbreak of Burkholderia cepacia infections. These infections ... Types of Infectionsplus icon * Central Line-associated Bloodstream Infectionsplus icon *Resources for Patients & Providers ... Facilities that identify infections caused by B. cepacia complex among non-CF patients or clusters of these infections among CF ... cepacia complex infections among patients with CF should be reported when infection rates appear above endemic rates. Cases ...
more infohttp://www.cdc.gov/hai/outbreaks/b-cepacia/index.html

Global Drugs for Burkholderia Pseudomallei Infections Market Professional Survey Report 2016Global Drugs for Burkholderia Pseudomallei Infections Market Professional Survey Report 2016

... sales value of Drugs for Burkholderia Pseudomallei InfectionsThis report studies Drugs for Burkholderia Pseudomallei Infections ... means the output of Drugs for Burkholderia Pseudomallei InfectionsRevenue, means the ... 10 Drugs for Burkholderia Pseudomallei Infections Marketing Type Analysis. 10.1 Drugs for Burkholderia Pseudomallei Infections ... 9.2 Drugs for Burkholderia Pseudomallei Infections Regional Market Trend. 9.2.1 North America 2016-2021 Drugs for Burkholderia ...
more infohttp://www.aarkstore.com/electronics/231067/global-drugs-for-burkholderia-pseudomallei-infections-market-professional-survey-report-2016

Glanders (Farcy, Burkholderia mallei infection, equinia, malleus)Glanders (Farcy, Burkholderia mallei infection, equinia, malleus)

Burkholderia malleli is able to cause two forms of human infection. Farcy is a subcutaneous form of the bacterial infection ... "Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei". Mil Med. vol. 174. 2009. pp. 647-51. ... "Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents". J ... The use of Burkholderia mallei as a biological weapon of mass destruction is a concern. If these bacteria were to be weaponized ...
more infohttp://www.clinicalpainadvisor.com/dermatology/glanders-farcy-burkholderia-mallei-infection-equinia-malleus/article/587919/

A Burkholderia pseudomallei Infection Imported from Eritrea to Israel | The American Journal of Tropical Medicine and HygieneA Burkholderia pseudomallei Infection Imported from Eritrea to Israel | The American Journal of Tropical Medicine and Hygiene

We have recently isolated Burkholderia pseudomallei from an Eritrean patient in Israel. The isolate was assigned a novel ... f A Burkholderia pseudomallei Infection Imported from Eritrea to Israel * Yaniv Almog1, Yael Yagel2, Yuval Geffen3, Pablo ... Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nature Microbiol 1: 1-5.[Crossref]. [ ... We have recently isolated Burkholderia pseudomallei from an Eritrean patient in Israel. The isolate was assigned a novel ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0481

Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis | CochraneTreatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis | Cochrane

Treatments to cure long-term infections with Burkholderia cepacia in people with cystic fibrosis. Review question ... This review highlights an urgent need for more research into new ways of treating long-term Burkholderia cepacia infection in ... Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with ... We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with ...
more infohttps://www.cochrane.org/CD009876/CF_treatments-cure-long-term-infections-burkholderia-cepacia-people-cystic-fibrosis

Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia...Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia...

Chronic infection with Burkholderia spp. defined by:. *One sputum (or bronchoalveolar lavage) culture positive for Burkholderia ... Infection. Communicable Diseases. Fibrosis. Cystic Fibrosis. Burkholderia Infections. Pathologic Processes. Pancreatic Diseases ... Gram-Negative Bacterial Infections. Bacterial Infections. Aztreonam. Anti-Bacterial Agents. Anti-Infective Agents. ... in Patients With Cystic Fibrosis and Chronic Burkholderia Species Infection. This study has been completed. ...
more infohttps://clinicaltrials.gov/show/NCT01059565

Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A...Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A...

Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Serological Evidence of Burkholderia pseudomallei Infection in U.S. Marines Who Trained in Australia From 2012-2014: A ... Burkholderia humptydooensis sp. nov., a new species related to Burkholderia thailandensis and the fifth member of the ...
more infohttps://health.mil/News/Articles/2019/07/01/Burkholderia-pseudomallei-Infection

Siderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia | Infection and ImmunitySiderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia | Infection and Immunity

1996) Epidemiology of Burkholderia cepacia infection in patients with cystic fibrosis: analysis by randomly amplified ... 1995) Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia ( ... Siderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia Patricia Darling, Maria Chan, Andrew D. Cox, Pamela ... Siderophore Production by Cystic Fibrosis Isolates of Burkholderia cepacia Patricia Darling, Maria Chan, Andrew D. Cox, Pamela ...
more infohttps://iai.asm.org/content/66/2/874?ijkey=7dcf4221091a7ecd21d9adf32bfb33cc03a7525c&keytype2=tf_ipsecsha
  • Overall, the B. pseudomallei strains showed evolutionary patterns similar to those of other chronic infections, including emergence of antibiotic resistance, genome reduction, and deleterious mutations in genes involved in virulence, metabolism, environmental survival, and cell wall components. (edu.au)
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