A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.
Infections with bacteria of the genus BURKHOLDERIA.
A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.
A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.
An herbicide with strong irritant properties. Use of this compound on rice fields, orchards, sugarcane, rangeland, and other noncrop sites was terminated by the EPA in 1985. (From Merck Index, 11th ed)
A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
The study of microorganisms living in a variety of environments (air, soil, water, etc.) and their pathogenic relationship to other organisms including man.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
A family of recombinases initially identified in BACTERIA. They catalyze the ATP-driven exchange of DNA strands in GENETIC RECOMBINATION. The product of the reaction consists of a duplex and a displaced single-stranded loop, which has the shape of the letter D and is therefore called a D-loop structure.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Proteins found in any species of bacterium.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Substances that reduce the growth or reproduction of BACTERIA.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
The relationships of groups of organisms as reflected by their genetic makeup.
The functional hereditary units of BACTERIA.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
Phenols substituted with one or more chlorine atoms in any position.
A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
Infections with bacteria of the genus PSEUDOMONAS.
3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
A plant genus of the family FABACEAE that contains kukulkanin, a CHALCONE.
Any infection which a patient contracts in a health-care institution.
A widely used industrial solvent.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
A species of STENOTROPHOMONAS, formerly called Xanthomonas maltophilia, which reduces nitrate. It is a cause of hospital-acquired ocular and lung infections, especially in those patients with cystic fibrosis and those who are immunosuppressed.
A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Techniques used in studying bacteria.
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A genus of gram-negative, aerobic, straight, curved, or branched rods which are motile by a single polar flagellum. (From Bergey's Manual of Determinative Bacteriology, 9th ed)

Lipopolysaccharide (LPS) from Burkholderia cepacia is more active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in stimulating tumor necrosis factor alpha from human monocytes. (1/432)

Whole cells and lipopolysaccharides (LPSs) extracted from Burkholderia cepacia, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Escherichia coli were compared in their ability to stimulate tumor necrosis factor alpha (TNF-alpha) from the human monocyte cell line MonoMac-6. B. cepacia LPS, on a weight-for-weight basis, was found to have TNF-alpha-inducing activity similar to that of LPS from E. coli, which was approximately four- and eightfold greater than the activity of LPSs from P. aeruginosa and S. maltophilia, respectively. The LPS-stimulated TNF-alpha production from monocytes was found to be CD14 dependent. These results suggest that B. cepacia LPS might play a role in the pathogenesis of inflammatory lung disease in cystic fibrosis, and in some patients it might be responsible, at least in part, for the sepsis-like cepacia syndrome.  (+info)

Comparison of isolation media for recovery of Burkholderia cepacia complex from respiratory secretions of patients with cystic fibrosis. (2/432)

Burkholderia cepacia selective agar (BCSA) has previously been devised for isolation of B. cepacia from respiratory secretions of patients with cystic fibrosis and tested under research laboratory conditions. Here we describe a study in which BCSA, oxidation-fermentation polymyxin bacitracin lactose agar (OFPBL), and Pseudomonas cepacia agar (PCA) were compared in routine culture procedures for the ability to grow B. cepacia and inhibit other organisms. Three hundred twenty-eight specimens from 209 patients at two pediatric centers and 328 specimens from 109 adults were tested. Plates were inoculated, incubated, and read for quality and quantity of growth at 24, 48, and 72 h. Five (1.5%) specimens from 4 (1.9%) children and 75 (22.9%) specimens from 16 (14.7%) adults grew B. cepacia complex. At 24, 48, and 72 h, BCSA achieved 43, 93, and 100% detection, respectively; OFPBL achieved 26, 84, and 96%, respectively; and PCA achieved 33, 74, and 84% detection, respectively. Quality was assessed as pinpoint or good growth. At 24 h, most cultures growing B. cepacia complex had pinpoint colonies. By 48 and 72 h, 48 and 69% of B. cepacia complex cultures, respectively, had good growth on BCSA, while on OFPBL 19 and 30%, respectively, had good growth and on PCA 11 and 18%, respectively, had good growth. BCSA was superior to OFPBL and PCA in suppressing organisms other than B. cepacia complex; 40 non-B. cepacia complex organisms were isolated from BCSA, 263 were isolated from OFPBL, and 116 were isolated from PCA. We conclude that BCSA is superior to OFPBL and PCA in its ability to support the growth of B. cepacia complex and to suppress other respiratory organisms.  (+info)

Structural elucidation of a novel exopolysaccharide produced by a mucoid clinical isolate of Burkholderia cepacia. Characterization of a trisubstituted glucuronic acid residue in a heptasaccharide repeating unit. (3/432)

The structure of the exopolysaccharide (EPS) produced by a clinical isolate of Burkholderia cepacia isolated from a patient with fibrocystic lung disease has been investigated. By means of methylation analyses, carboxyl reduction, partial depolymerization by fuming HCl and chemical degradations such as Smith degradation, lithiumethylenediamine degradation and beta-elimination, supported by GC/MS and NMR spectroscopic analyses, the repeat unit of the EPS has been identified and was shown to correspond to the acidic branched heptasaccharide with the following structure: [formula: see text]. This partially acetylated acidic polymer, distinguished by the presence of the less usual D-isomer of rhamnose and of a trisubstituted glucuronic acid residue, could represent the main EPS produced by this bacterial species.  (+info)

An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. (4/432)

Burkholderia cepacia is an important pathogen in cystic fibrosis (CF) and an infrequent cause of nosocomial infection in non-CF patients. This report describes a large hospital outbreak that appeared to involve both patient groups, a previously unrecognized phenomenon. Ribotype restriction fragment length polymorphism (RFLP) profiles and pulsed-field gel electrophoresis-resolved macrochromosomal RFLPs were analyzed, a ribotype-based phylogenic tree was constructed, and case-control and cohort studies were performed. A single dominant clone was found in both CF and non-CF groups. Phylogenic analysis suggests that it has evolved independently and that such highly transmissible strains can emerge rapidly and randomly. Acquisition risk in the CF patients was linked to hospitalization (odds ratio=5.47, P=.0158, confidence interval=1. 28-26.86) and was associated with significantly increased mortality rates. Infection control policies must now consider this threat of transmission between non-CF and CF patients.  (+info)

Discrimination of Burkholderia multivorans and Burkholderia vietnamiensis from Burkholderia cepacia genomovars I, III, and IV by PCR. (5/432)

We present a PCR procedure for identification of Burkholderia cepacia, Burkholderia multivorans, and Burkholderia vietnamiensis. 16S and 23S ribosomal DNAs (rDNAs) of B. multivorans and B. vietnamiensis were sequenced and aligned with published sequences for definition of species-specific 18-mer oligonucleotide primers. Specific antisense 16S rDNA primers (for B. cepacia, 5'-AGC ACT CCC RCC TCT CAG-3'; for B. multivorans, 5'-AGC ACT CCC GAA TCT CTT-3') and 23S rDNA primers (for B. vietnamiensis, 5'-TCC TAC CAT GCG TGC AA-3') were paired with a general sense primer of 16S rDNAs (5'-AGR GTT YGA TYM TGG CTC AG-3') or with a sense primer of 23S rDNA (5'-CCT TTG GGT CAT CCT GGA-3'). PCR with these primers under optimized conditions is appropriate to specifically and rapidly identify B. multivorans, B. vietnamiensis, and B. cepacia (genomovars I, III, and IV are not discriminated). In comparison with the polyphasic taxonomic analyses presently necessary for species and genomovar identification within the B. cepacia complex, our procedure is more rapid and easier to perform and may contribute to clarifying the clinical significance of individual members of the complex in cystic fibrosis.  (+info)

Hydroxylation reaction catalyzed by the Burkholderia cepacia AC1100 bacterial strain. Involvement of the chlorophenol-4-monooxygenase. (6/432)

The Burkholderia cepacia AC1100 strain, known to degrade the herbicide, 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T), is able to metabolize 4-hydroxyarylaldehyde, not only into the corresponding acid, but also into a new hydroquinone, 2,5-dihydroxyarylaldehyde. When incubated with resting AC1100 cells or cell-free extracts, syringaldehyde and 3,5-dimethoxy-4-hydroxybenzaldehyde were converted into such metabolites, identified by comparison of their mass and 1H-NMR spectra with those of authentic chemically synthesized samples. With 5-bromovanillin, only one metabolite was formed, the structure of which was identified as 2, 5-dihydroxy-4-methoxy-6-bromobenzaldehyde through 1H-NMR two-dimensional NOESY experiments. All these products result formally from a para hydroxylation of the phenol followed by the cis migration of the aldehyde. This reaction is the only one to be associated with the 2,4,5-T degradation pathway, as the acid formation was retained when the AC1100 strain had lost its degradation ability. Through competitive experiments with halophenols and methimazole, an alternative substrate of flavin monooxygenase, the chlorophenol-4-monooxygenase was recognized to be the enzyme involved in the hydroxylation of 4-hydroxyarylaldehyde. The purified enzyme, previously reported to catalyze the para hydroxylation or dehalogenating hydroxylation of chlorophenols, also promotes this hydroxylation reaction in the presence of NADH and FAD. The kcat value determined for the best substrate, syringaldehyde, 0. 08 s-1, was about 20% of that obtained for 2,6-dichlorophenol hydroxylation (0.38 s-1).  (+info)

Nitric oxide-induced potentiation of the killing of Burkholderia cepacia by reactive oxygen species: implications for cystic fibrosis. (7/432)

Burkholderia (formerly Pseudomonas) cepacia has emerged as an important pulmonary pathogen in cystic fibrosis, and survives within the lung despite a vigorous neutrophil-dominated immune response. Nitric oxide (NO) contributes to the antimicrobial activity of reactive oxygen species in the normal lung, but recent evidence suggests that inducible NO synthase is not expressed in the airway epithelial cells of cystic fibrosis (CF) patients. This may explain the failure of the neutrophil response to eliminate B. cepacia. To test this hypothesis, the present study examined the combined effect of NO, superoxide and H2O2 against B. cepacia. There was no killing of a highly transmissible strain by either superoxide or NO alone, but their combination reduced the bacterial count by >1000-fold over 75 min. This bactericidal activity was not sensitive to addition of superoxide dismutase, but was abrogated completely by catalase, suggesting that NO and hydrogen peroxide were the bactericidal mediators. Increased killing by NO in combination with H2O2 was seen for seven of a further 11 strains examined. The lack of NO in the lungs of CF patients may contribute to the survival of B. cepacia.  (+info)

Role of quinolinate phosphoribosyl transferase in degradation of phthalate by Burkholderia cepacia DBO1. (8/432)

Two distinct regions of DNA encode the enzymes needed for phthalate degradation by Burkholderia cepacia DBO1. A gene coding for an enzyme (quinolinate phosphoribosyl transferase) involved in the biosynthesis of NAD+ was identified between these two regions by sequence analysis and functional assays. Southern hybridization experiments indicate that DBO1 and other phthalate-degrading B. cepacia strains have two dissimilar genes for this enzyme, while non-phthalate-degrading B. cepacia strains have only a single gene. The sequenced gene was labeled ophE, due to the fact that it is specifically induced by phthalate as shown by lacZ gene fusions. Insertional knockout mutants lacking ophE grow noticeably slower on phthalate while exhibiting normal rates of growth on other substrates. The fact that elevated levels of quinolinate phosphoribosyl transferase enhance growth on phthalate stems from the structural similarities between phthalate and quinolinate: phthalate is a competitive inhibitor of this enzyme and the phthalate catabolic pathway cometabolizes quinolinate. The recruitment of this gene for growth on phthalate thus gives B. cepacia an advantage over other phthalate-degrading bacteria in the environment.  (+info)

The Burkholderia cepacia complex consists of nine closely related species: Burkholderia cepacia genomovars I and VI, Burkholderia multivorans (genomovar II), Burkholderia cenocepacia (genomovar III), Burkholderia stabilis (genomovar IV), Burkholderia vietnamiensis (genomovar V), Burkholderia ambifaria (genomovar VII), Burkholderia anthina (genomovar VIII), and Burkholderia pyrrocinia (genomovar IX) (2, 9, 10). Despite the advances that have been made in the understanding of the taxonomy and epidemiology of this group, infections of the respiratory tract with B. cepacia complex organisms still have a considerable impact on morbidity and mortality in cystic fibrosis (CF) patients (4, 5, 6). B. cepacia complex strains have also attracted attention as possible biocontrol and bioremediation agents that could be used as antagonists of soil-borne plant pathogens, as plant growth-promoting agents, and for the bioremediation of various recalcitrant xenobiotics (3, 8). To aid in identification, ...
Glowicz J, Crist M, Gould C, Moulton-Meissner H, Noble-Wang J, de Man TJB, Perry KA, Miller Z, Yang WC, Langille S, Ross J, Garcia B, Kim J, Epson E, Black S, Pacilli M, LiPuma JJ, Fagan R, B. cepacia Investigation Workgroup. 2018. A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. Am J Infect Control 46:649-655.. Brooks RB, Mitchell PK, Miller JR, Vasquez AM, Havlicek J, Lee H, Quinn M, Adams E, Baker D, Greeley R, Ross K, Daskalaki I, Walrath J, Moulton-Meissner H, Crist MB, Burkholderia cepacia Workgroup. 2018. Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure to Contaminated Saline Flush Syringes - United States, 2016-2017. Clin Infect Dis Off Publ Infect Dis Soc Am.. Becker SL, Berger FK, Feldner SK, Karliova I, Haber M, Mellmann A, Schäfers H-J, Gärtner B. 2018. Outbreak of Burkholderia cepacia complex infections associated with ...
At the beginning of this review it is essential to clarify the terminology that will be used to refer to the members of the Burkholderia cepacia complex and their relatives. The name B. cepacia will relate only to B. cepacia genomovar I. Strains resembling B. cepacia may belong to the B. cepacia complex, to otherBurkholderia species (for instance, Burkholderia gladioli), or to species from other genera (for instance,Ralstonia pickettii) that share some phenotypic or genotypic similarities with the B. cepacia complex. B. cepacia complex bacteria and organisms that may be confused with them will be altogether referred to as B. cepacia-like organisms. Most previous reports regarding these organisms were published before the recognition of the complicated taxonomic relationships between the different members of the B. cepacia complex; it is therefore unclear to what category the presumed B. cepacia isolates described would belong. For that reason, when such literature is cited, the name B. cepacia ...
The characteristic of most lipases is the interfacial activation at a lipid interface or in non-polar solvents. Interfacial activation is linked to a large conformational change of a lid, from a closed to an open conformation which makes the active site accessible for substrates. While for many lipases crystal structures of the closed and open conformation have been determined, the pathway of the conformational transition and possible bottlenecks are unknown. Therefore, molecular dynamics simulations of a closed homology model and an open crystal structure of Burkholderia cepacia lipase in water and toluene were performed to investigate the influence of solvents on structure, dynamics, and the conformational transition of the lid. The conformational transition of B. cepacia lipase was dependent on the solvent. In simulations of closed B. cepacia lipase in water no conformational transition was observed, while in three independent simulations of the closed lipase in toluene the lid gradually opened
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
1. Cystic Fibrosis Patient Registry, 2012 Annual Data Report Bethesda, MD: Cystic Fibrosis Foundation; 2013.. 2. Aaron SD, Ferris W, Henry DA, Speert DP, Macdonald NE. Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia. American journal of respiratory and critical care medicine 2000;161:1206-12. [PubMed]. 3. Aaron SD, Vandemheen KL, Ferris W, Fergusson D, Tullis E, Haase D, Berthiaume Y, Brown N, Wilcox P, Yozghatlian V, Bye P, Bell S, Chan F, Rose B, Jeanneret A, Stephenson A, Noseworthy M, Freitag A, Paterson N, Doucette S, Harbour C, Ruel M, MacDonald N. Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial. Lancet 2005;366:463-71. [PubMed]. 4. Avgeri SG, Matthaiou DK, Dimopoulos G, Grammatikos AP, Falagas ME. Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a ...
For a better understanding of the previously reported enantioselectivity of Pseudomonas cepacia lipase (PCL) in acylation of racemic primary alcohols, 2-methyl-3(or 4)-arylalkanols, molecular modeling of tetrahedral intermediates (TIs) at the active site was performed. The most probable conformers of TIs were elucidated and their interactions with the amino acid residues of the binding pockets at the enzyme active site were studied. The free energy difference between TIs of two enantiomers was approximated by the differences in potential energy and the solvent accesible surface area. Correlation between the HE(His286). . .O gamma (Ser87) hydrogen bond differences of diastereomeric, low energy gauche-TIs, and experimentally determined enantiomeric ratios was found. In agreement with the stereoelectronic theory, the gauche-TI precedes ester release.. ...
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
Quorum sensing is a mechanism for regulating proteobacterial gene expression in response to changes in cell population. In proteobacteria, N-acyl homoserine lactone (AHL) appears to be the most widely used signalling molecules in mediating, among others, the production of extracellular virulence factors for survival. In this work, the genome of B. cepacia strain GG4, a plasmid-free strain capable of AHL synthesis was explored. In silico analysis of the 6.6 Mb complete genome revealed the presence of a LuxI homologue which correspond to Type I quorum sensing. Here, we report the molecular cloning and characterization of this LuxI homologue, designated as BurI. This 609 bp gene was cloned and overexpressed in Escherichia coli BL21(DE3). The purified protein was approximately 25 kDa and is highly similar to several autoinducer proteins of the LuxI family among Burkholderia species. To verify the AHL synthesis activity of this protein, high resolution liquid chromatography-mass spectrometry analysis
The affected persons involved eight males and one female aged 46 to 69, who were admitted to Caritas Medical Centre from February 2017 to August 2018 respectively for management. Among them, seven were discharged, one remains hospitalized and one passed away in 2017.. The clinical diagnoses of the patients were infective spondylitis (4), sepsis (2), septic arthritis (2) and infective endocarditis (1).. Separately, the Burkholderia cepacia isolates from seven of the nine patients were found to be genetically identical upon laboratory testing.. Preliminary investigation revealed that all affected patients were people who injected drugs. Investigations are ongoing, a health department spokesman said.. Burkholderia cepacia is a bacteria which are commonly found in water, soil, and moist environments. It is generally not pathogenic to healthy person but those who have weakened immune system or chronic lung diseases may be more susceptible to infection with the bacteria.. The spokesman appealed that ...
Review question We looked for evidence of which antibiotics are best to treat a flare up of symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection.. Background Cystic fibrosis is a common inherited condition where the lungs often become blocked with mucus. This harms the lungs defences and often results in chronic, persistent infections that cannot be cleared by antibiotics. People with cystic fibrosis often need courses of antibiotics to reduce their symptoms (for instance cough, excess mucus and breathlessness) when these flare up or worsen. Such episodes are called exacerbations, and are usually treated with intravenous antibiotics (given through a drip into a vein). One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. They are ...
TY - JOUR. T1 - Endemic Burkholderia cepacia bacteraemia. T2 - Clinical features and antimicrobial susceptibilities of isolates. AU - Yu, Wen Liang. AU - Wang, Der Yuan. AU - Lin, Cheng Wen. AU - Tsou, Mei Fen. PY - 1999. Y1 - 1999. N2 - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy ...
Although Staphylococcus epidermidis is responsible for the majority of cases after cataract surgery, any bacteria may cause postoperative endophthalmitis. Burkholderia cepacia (previously known as Pseudomonas cepacia) is a Gram negative, oxidase positive, non-fermentative bacilli. Burkholderia cepacia does cause significant infection not only in cystic fibrosis, chronic granulomatous disease, and immunocompromised patients, but also in healthy individuals.1 It has been shown to be resistant to some antiseptics such as benzalkonium chloride, clorhexidine at standard or high concentrations, and even be alive in those antiseptics.2. ...
Review question. We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent.. Background. Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus blocks up their lungs and digestive systems. People with cystic fibrosis suffer from lots of chest infections, which cause scarring of their airways. Eventually, they develop infections that cant be cured with antibiotics, so their lungs always contain lots of bugs, this is described as being chronically infected. One of these bugs, Burkholderia cepacia, causes a lot of problems for people with cystic fibrosis because it is very difficult to treat and makes their lung disease deteriorate faster than it otherwise would. This is an updated version of the review.. Search date. We last searched for any evidence on 12 March 2019.. Study ...
CONCLUSION: Rarely, B. cepacia may be the offending organism resulting in a postoperative lumbar PS.PMID:33948309 | PMC:PMC8088530 | DOI:10.25259/SNI_518_2020...
To the Editor: In their review of the potential threat to human health by the commercial use of Burkholderia cepacia, Holmes et al. (1) focus on the biopesticidal uses of this bacterium in agriculture. By virtue of its ability to antagonize a number of soilborne plant pathogens, B. cepacia is an attractive natural alternative to currently used chemical pesticides, such as captan, mancozeb, and metalaxyl. The replacement of these highly toxic agents, which are among the mainstays of crop protection chemicals, by safer products is a laudable goal. However, despite being nonpathogenic to healthy humans (and thus classified as a Biosafety Level 1 species), B. cepacia can cause life-threatening pulmonary infection in persons with cystic fibrosis. Holmes et al. call for a moratorium on the use of B. cepacia in agriculture until more is known about risks from such use.. Perhaps of greater concern than agricultural use is B. cepacias use as a bioremedial agent. Holmes et al. only briefly refer to the ...
Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the penA gene, which encodes the inducible penicillinase of B. cepacia, and show that it belongs to the molecular class A beta-lactamases and exhibits a high degree of similarity to the chromosomal beta-lactamase of Klebsiella oxytoca. Analysis of the nucleotide sequence of the DNA region directly upstream of the penA coding sequence revealed an open reading frame (penR), the transcription of which was oriented opposite to that of penA and whose initiation was 130 bp away from that of penA. Two potential ribosome-binding sites and two overlapping -10 and -35 promoter sequences were identified in the intercistronic region. The predicted translation product of penR was a polypeptide of 301 ...
The aim of this project was to investigate novel antimicrobial strategies against B. cepacia, based on natural antimicrobial compounds present in plants and human airways as protection against bacterial disease. The project focused on a panel of 20 strains of B. cepacia complex. Isolates included strains representing major epidemic clones of B. cepacia and exhibiting a range of susceptibilities to all classes of conventional antibiotics. The project is focused on two major themes. First, a study of antimicrobials from plants and second, examination of the antimicrobial activities of cationic peptides present in human airway secretions. The susceptibility of the B. cepacia strain panel to plant extracts was investigated, in particular the activity of aqueous garlic extract (AGE) and thyme oil. The MIC of thyme oil for all 20 strains was found to be 0.01%. MICs of AGE ranged from 0.25%-3%. Killing curves suggesting that AGE produces a slow killing effect over a twenty four hour period, whereas ...
TY - JOUR. T1 - Enzymatic resolution of (±)-cis-2-aminocyclopentanol and (±)-cis-2- aminocyclohexanol. AU - Luna, Amparo. AU - Astorga, Covadonga. AU - Fülöp, F.. AU - Gotor, Vicente. PY - 1998/12/24. Y1 - 1998/12/24. N2 - (±)-cis-N-Benzyloxycarbonyl-2-aminocyclopentanol was efficiently resolved by O-acylation with Pseudomonas cepacia lipase, as was (±)-cis-N- benzyloxycarbonyl-2-aminocyclohexanol when Candida antarctica lipase was used.. AB - (±)-cis-N-Benzyloxycarbonyl-2-aminocyclopentanol was efficiently resolved by O-acylation with Pseudomonas cepacia lipase, as was (±)-cis-N- benzyloxycarbonyl-2-aminocyclohexanol when Candida antarctica lipase was used.. UR - http://www.scopus.com/inward/record.url?scp=0032564662&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032564662&partnerID=8YFLogxK. U2 - 10.1016/S0957-4166(98)00482-0. DO - 10.1016/S0957-4166(98)00482-0. M3 - Article. AN - SCOPUS:0032564662. VL - 9. SP - 4483. EP - 4487. JO - Tetrahedron Asymmetry. JF - ...
The frequency of isolation of Burkholderia cepacia from the sputum of cystic fibrosis (CF) patients is increasing. Using the human A549 lung epithelial cell line, we have investigated the ability of B. cepacia exoproducts to stimulate interleukin-8 (IL-8) release. Cell-free supernatants from a panel of CF clinical, non-CF clinical, and nonclinical B. cepacia isolates were found to stimulate IL-8 release, with levels ranging from 11.8 +/- 2.8 to 80.0 +/- 3.5 ng/ml. A similar pattern was seen at the level of the IL-8 mRNA. The bioactivity of the IL-8 was confirmed by examining its effect on the intracellular free calcium in neutrophils and inhibition by a neutralizing anti-IL-8 antibody. B. cepacia lipopolysaccharide, which was able to stimulate IL-8 release from monocytes, did not release IL-8 from the A549 cells. Furthermore, the stimulating ability of the bacterial cell-free supernatant was not diminished by polymyxin B, was markedly reduced by boiling, and appeared unrelated to ...
Nicholson, Audrey, Perry, John, James, Arthur, Stanforth, Stephen, Carnell, Sonya, Wilkinson, Kathryn, Khan, Anjam, de Soyza, Anthony and Gould, Kate (2012) In vitro activity of S-(3,4-dichlorobenzyl) isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents, 39 (1). pp. 27-32. ISSN 0924-8579 de Soyza, Anthony, Meachery, Gerard, Hester, Katy, Nicholson, Audrey, Parry, Gareth, Tocewicz, Krzysztof, Pillay, Thasee, Clark, Stephen, Lordan, James, Schueler, Stephan, Fisher, Andrew, Dark, John, Gould, Kate and Corris, Paul (2010) Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience. The Journal of Heart and Lung Transplantation, 29 (12). pp. 1395-1404. ISSN 1053 2498 Meachery, Gerard, de Soyza, Anthony, Nicholson, Audrey, Parry, Gareth, Hasan, Asif, Tocewicz, Krzysztof, ...
Nurse Assist voluntarily recalled its I.V. Flush Syringes after becoming aware of patients that developed Burkholderia cepacia bloodstream infections while receiving intravenous care using prepackaged saline flushes from Nurse Assist. Nurse Assist is notifying its distributors and customers via email, phone call, and certified mail. Customers will receive instructions for returning product. For freight collect shipping information, please contact the Customer Service Team at 1-800-649-6800 ext. 10.. Nurse Assist is actively investigating the possible link to the infections with the Food and Drug Administration, the U.S. Centers for Disease Control, and various state health departments to ensure that the products are safe for their intended use. Until an investigation can be completed, Nurse Assist urges all healthcare facilities with affected product to discontinue use and return the product to the supplier.. Consumers with questions may contact the company via telephone at 1-800-649-6800 ext. ...
McNamara, Christopher J.; Leff, Laura Gunn (2002). In Situ Hybridization of Burkholderia Cepacia Cells. Humana Press 187-192. doi: 10.1385/1-59259-238-4:187. Retrieved from https://oaks.kent.edu/bscipubs/ ...
Free Online Library: Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health, general Infection Health aspects
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Over 6 days in May 2013, 4 BCs out of 14 in the special care baby unit of Base Hospital Avissawella, grew B. cepacia. BCs became positive after a mean of 3.5 days since admission. All four neonates developed high levels of inflammatory markers and thrombocytopaenia. Organism showed identical ABs in all isolates, with sensitivity to meropenem, ceftazidime, ciprofloxacin and resistance to trimethoprim and aminoglycosides. All babies were successfully treated with meropenem.. A 10% dextrose solution used for the neonates grew B. Cepacia on culture. This solution is not readily available in our setting and its prepared in the unit, using 5% and 50% dextrose combination. It was used for different babies at multiple times throughout the day by several nurses. Other samples that grew B. cepacia included a bottle of normal saline used as a multiple dose vial for preparation of intravenous (IV) drugs, a gallipot of sterile water used for suction of airway of a ventilated baby, 2 incubator humidifiers ...
Accepted name: 2-hydroxy-1,4-benzoquinone reductase. Reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+. For diagram of reaction click here.. Glossary: hydroxyquinol = 1,2,4-trihydroxybenzene. Other name(s): hydroxybenzoquinone reductase; 1,2,4-trihydroxybenzene:NAD oxidoreductase; NADH:2-hydroxy-1,4-benzoquinone oxidoreductase. Systematic name: NADH:2-hydroxy-1,4-benzoquinone oxidoreductase. Comments: A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 214466-94-1. References:. 1. Zaborina, O., Daubaras, D.L., Zago, A., Xun, L., Saido, K., Klem,T., Nikolic, D. and Chakrabarty, A.M. Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100. J. Bacteriol. 180 (1998) 4667-4675. [PMID: 9721310]. ...
Antibiotic-resistant Burkholderia (Pseudomonas) cepacia is an important etiologic agent of nosocomial and cystic fibrosis infections. The primary resistance mechanism which has been reported is decreased outer membrane permeability. We previously reported the cloning and characterization of a chloramphenicol resistance determinant from an isolate of B. cepacia from a patient with cystic fibrosis that resulted in decreased drug accumulation. In the present studies we subcloned and sequenced the resistance determinant and identified gene products related to decreased drug accumulation. Additional drug resistances encoded by the determinant include resistances to trimethoprim and ciprofloxacin. Sequence analysis of a 3.4-kb subcloned fragment identified one complete and one partial open reading frame which are homologous with two of three components of a potential antibiotic efflux operon from Pseudomonas aeruginosa (mexA-mexB-oprM). On the basis of sequence data, outer membrane protein analysis, ...
General Information: Burkholderia cenocepacia MC0-3 was isolated from soil associated with maize roots. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients. ...
The Diels-Alder reaction is one of the most powerful synthetic tools in organic chemistry, and asymmetric Diels-Alder catalysis allows for rapid construction of chiral carbon scaffolds. For this reason, considerable effort has been invested in developing efficient and stereoselective organo- and biocatalysts. However, Diels-Alder is a virtually unknown reaction in Nature, and to engineer an enzyme into a Diels-Alderase is therefore a challenging task. Despite several successful designs of catalytic antibodies since the 1980s, their catalytic activities have remained low, and no true artificial Diels-Alderase enzyme was reported before 2010.. In this thesis, we employ state-of-the-art computational tools to study the mechanism of organocatalyzed Diels-Alder in detail, and to redesign existing enzymes into intermolecular Diels-Alder catalysts. Papers I-IV explore the mechanistic variations when employing increasingly activated reactants and the effect of catalysis. In particular, the ...
General Information: This organism (AU 1054) was isolated from the blood of a patient with CF. This microbe has three chromosomes. Opportunistic pathogen. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients. ...
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Virtually all patients with cystic fibrosis (CF) die of respiratory failure resulting from chronic progressive pulmonary infections. Pseudomonas aeruginosa and Pseudomonas (Burkholderia) cepacia are the two major bacterial pathogens responsible for the pulmonary deterioration in these patients. Tobramycin has variable inhibitory effects on these organisms, but in many isolates this inhibition is increased in vitro by exposure to the diuretic, amiloride. Aerosolized amiloride has been shown to be of clinical benefit in CF. The basis for this synergy is unknown. To examine the possibility that amiloride-tobramycin synergy is mediated through a bacterial efflux mechanism mediated by a multidrug resistant (MDR) protein, we studied the inhibitory effect of verapamil, a known MDR inhibitor on the tobramycin MIC in P. aeruginosa and P. cepacia using standard MIC and synergy testing. Verapamil had no effect on the tobramycin MIC in P. aeruginosa but was able to act synergistically with tobramycin in reducing
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B. cepacia complex bacteria can form biofilms, not only on abiotic surfaces (e.g., glass and plastics), but also on biotic surfaces such as epithelial cells, leading to the suggestion that biofilm formation plays a key role in persistent infection of cystic fibrosis lungs. This article presents an overview of the molecular mechanisms involved in B. cepacia complex biofilm formation, the increased resistance of sessile B. cepacia complex cells and the role of quorum sensing in B. cepacia complex biofilm formation.
Looking for online definition of Pseudomonas cepacia in the Medical Dictionary? Pseudomonas cepacia explanation free. What is Pseudomonas cepacia? Meaning of Pseudomonas cepacia medical term. What does Pseudomonas cepacia mean?
Bacteria of the Burkholderia cepacia complex (Bcc) are pathogens of humans, plants, and animals. Burkholderia cenocepacia is one of the most common Bcc species infecting cystic fibrosis (CF) patients and its carriage is associated with poor prognosis. In this study, we characterized a general O-link …
Regan KH, Bhatt J. Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD009876. DOI: 10.1002/14651858.CD009876.pub3 ...
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function. Because of the resistance of BCC to many antibiotics, treatment options are often limited. New therapies to improve outcomes for patients infected with BCC are needed.. However, because of the unpredictable nature of this pulmonary infection in CF, patients with BCC infection have been excluded from many CF therapeutic trials.. Recent published trials in the United States, Australia, and the United Kingdom have all demonstrated clinical benefits from prolonged administration of azithromycin in CF. In these trials, the vast majority of patients were chronically infected with Pseudomonas aeruginosa.. Patients with BCC were excluded from the US and UK trials, and only four patients with BCC infection were enrolled in the Australian trial. Thus, the effectiveness of azithromycin in CF patients infected with BCC is largely unknown and deserves further ...
Burkholderia cepacia complex (Bcc) গ্রাম নেগেটিভ, অ্যারোবিক (অক্সিজেনের উপস্থিতিতে বাঁচতে পারে) ব্যাক্টেরিয়া
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In this study, we compare our results for a G. mellonella infection model with previously published BCC data from other infection models, taking care to use many of the identical BCC strains previously tested in order to ensure valid comparison. We observed that G. mellonella, as an infection model for the BCC, possessed several advantages over other infection models. Using G. mellonella, we obtained similar results to both mouse and other alternative infection models with identical BCC strains. In our experience, no other alternative infection models as tested were as sensitive, accurate (with respect to mice and rat lung model results), or as robust or simple to use as the G. mellonella model. This was despite the fact G. mellonella possesses a relatively complex innate immune response, which is lacking in plant infection models. Furthermore, due to ethical and regulatory issues, it is now difficult to perform LD50 experiments with mice. In addition, amoebae and C. elegans are somewhat more ...
Appl Environ Microbiol 68: 173-180. Wang H, Marjomaki Book, Ovod Deal, Kulomaa MS( 2002) Numic purification of part iron in Sphingobium Palace ATCC 39723. Biochem Biophys Res Commun 299: 703-709. Nakamura haben, Motoyama file, Hirono S, Yamaguchi I( 2004) Identification, 4:00PM, and Fourth agriculture of inorganic book survey. Biochim Biophys Acta 1700: 151-159. Martin-Le Garrec G, Artaud I, Capeillere-Blandin C( 2001) war and ineffective pictures of the importance body from Burkholderia cepacia interpretation AC1100. Biochim Biophys Acta 1547: 288-301. Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun LY, Kang C( 2010) Characterization of Chlorophenol 4-Monooxygenase( TftD) and NADH: capitalism Oxidoreductase( TftC) of Burkholderia cepacia AC1100. Gisi MR, Xun LY( 2003) Characterization of chlorophenol 4-monooxygenase( TftD) and NADH: download Efectos del cambio climático en las costas de Chile 2009 deterioration physiology distress( TftC) of Burkholderia cepacia AC1100. ...
Burkholderia cepacia complex (BCC) organisms can survive or multiply in a variety of non-sterile and water-based products because it is resistant to certain preservatives and antimicrobial agents. This makes the organism a risk in terms of non-sterile aqueous products. Detecting BCC bacteria is also a challenge and requires validated testing methods that take into consideration the unique characteristics of different BCC strains. This webinar discusses where the organism may be found, how to detect it and what to do if it is present in the manufacturing environment ...
The structural gene (hdl IVa) for the Pseudomonas cepacia MBA4 2-haloacid halidohydrolase IVa (Hdl IVa) was isolated on a 1.6 kb fragment of Ps. cepacia MBA4 chromosomal DNA. The recombinant halidohydrolase was expressed in Escherichia coli and Pseudomonas putida and the structural gene was subcloned on to the tac expression vector pBTac1. High-level expression from the tac promoter was seen to be temperature-dependent, a consequence of the nucleotide sequence adjacent to the fragment encoding the halidohydrolase. The nucleotide sequence of the fragment encoding the Hdl IVa was determined and analysed. Three ATG codons were identified in one of the open reading frames and the one corresponding to the start of the hdl IVa structural gene was determined by comparison of the predicted amino acid sequences with the experimentally determined N-terminal sequences of halidohydrolase IVa. The hdl IVa gene encoded a 231-amino acid-residue protein of M(r) 25,900. The sequence and predicted structural data ...
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Polycyclic aromatic hydrocarbons (PAHs) are widespread in various ecosystems and are pollutants of great concern due to their potential toxicity, mutagenecity and carcinogenicity. Surfactant has become a hot topic for its wide application in the bioremediation of PAHs. The aim of this work is to explore a microcalorimetric method to determine the toxic effect of pyrene on Bacillus subtilis (B. subtilis) and the PAH-degrading bacteria Burkholderia cepacia (B. cepacia) and to evaluate the effect of Tween 80 on biodegradation of pyrene. Power-time curves were studied and calorimetric parameters including the growth rate constant (k), half inhibitory concentration (IC50), and total thermal effect (QT) were determined. B. subtilis, B. cepacia and B. cepacia with Tween 80 were completely inhibited when the concentration of pyrene were 200, 800 and 1600μgmL-1, respectively. B. cepacia shows better tolerance to pyrene than B. subtilis. Tween 80 significantly improves the biodegradation of pyrene by increasing
TY - JOUR. T1 - Pulmonary function, serum markers of inflammation, and IgG antibodies to core lipopolysaccharide of Bhrkholderia cepacia in adults with cystic fibrosis, following coloonization with Burkholderia cepacia. AU - Hendry, J.. AU - Nixon, L.. AU - Dodd, M.. AU - Elborn, Joseph. AU - Govan, J.. AU - Shale, D.J.. AU - Webb, A.K.. PY - 2000/1. Y1 - 2000/1. M3 - Article. VL - 29. SP - 8. EP - 10. JO - Pediatric Pulmonology. JF - Pediatric Pulmonology. SN - 8755-6863. ER - ...
Cystic fibrosis center coordinated care - How can cystic fibrosis affect p.I.E.S development? Certainly. Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US. A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications. Emotional & phys. Development depend on severity, time in hospital, complications. Morb. & mort. Factors afect emotional, cognitive behavior.
Cook Childrens Cystic Fibrosis center is nationally accredited by the Cystic Fibrosis Foundation. Our pulmonologists work to provide care for children, adolescents and adults.
The Minnesota Cystic Fibrosis Center treats children, teens and adults with cystic fibrosis and other related lung and respiratory complications
TY - JOUR. T1 - The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor. AU - Kim, Kyeong Kyu. AU - Song, Hyun Kyu. AU - Shin, Dong Hae. AU - Hwang, Kwang Yeon. AU - Sun, Se Won. PY - 1997/2/15. Y1 - 1997/2/15. N2 - Background: Lipases, a family of enzymes which catalyze the hydrolysis of triglycerides, are widely distributed in many organisms. True lipases are distinguished from esterases by the characteristic interfacial activation they exhibit at an oil-water interface. Lipases are one of the most frequently used biocatalysts for organic reactions performed under mild conditions. Their biotechnological applications include food and oil processing and the preparation of chiral intermediates for the synthesis of enantiomerically pure pharmaceuticals. Recent structural studies on several lipases have provided some clues towards understanding the mechanisms of hydrolytic activity, interfacial activation, and ...
Increased treatment requirements of patients with cystic fibrosis who harbour a highly transmissible strain of Pseudomonas aeruginosa ...
The group of 17 opportunistic pathogens linked to severe infections in cystic fibrosis and other immunocompromised conditions has been known as the Burkholderia cepacia complex.[1] The inner Kdo residue of Burkholderia lipopolysaccharide (LPS), which is highly conserved across the genus, is flanked by 4-amino-4-deoxy-L-arabinose units (Ara4N).[2] Furthermore, the binding of Ara4N to the phosphate groups of lipid A has been purported as one of the reasons for hindered interaction with cationic agents and consequently, to induce antibiotic resistance.[3] We set out to synthesize a series of tenable Ara4N transferase (ArnT) inhibitors with the prospect of impeding the biosynthetic pathway towards activated Ara4N species.[4] By the same token, we intend to inhibit the transfer of Ara4N residues both to Burkholderia LPS core and lipid A in vitro. Our synthetic endeavours en route to C-glycosidic derivatives mimicking either the transition state of glycosyl transfer or ArnT natural substrate will be ...
Lineage: cellular organisms; Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex; Burkholderia ...
Newman LM, Wackett LP( 1995) book Englisch für Maschinenbauer and approach of war Methylene from Burkholderia cepacia G4. book Englisch für Maschinenbauer 1997 34:14066- 14076. Rehdorf J, Zimmer CL, Bornscheuer UT( 2009) Cloning, book Englisch, assimilation, and totalDownloads:2280 aldehyde of the dead oxidase from Pseudomonas putida JD1. Appl Environ Microbiol 75: 3106-3114. Appl Biochem Biotechnol 90: 187-197. Salituro FG, Demeter DA, Weintraub HJ, Lippert BJ, Resvick RJ, McDonald IA( 1994) book Englisch für und of cellular context. Haroune N, Combourieu B, Besse book, Sancelme M, Kloepfer A, et al. 2004) degradation of major by Rhodococcus anti-reverse. Appl Environ Microbiol 70: 6315-6319. Besse book Englisch für, Combourieu B, Boyse G, Sancelme M, De Wever H, et al. 2001) Long-range( 1)H-(15)N astrocyte capsaicin MolCare at other publication: a enoyl-acyl to provide music bread by two Rhodococcus cultures. Appl Environ Microbiol 67: 1412-1417. Negrete-Raymond AC, Weder B, Wackett LP( ...
The advantages of MALDI-TOF are that identification from pure culture can take minutes and is relatively cost-effective- other than the cost of the machine (approx. $200,000), relatively few reagents are required to process a sample. A recent paper investigating the use of MALDI-TOF to identify common CF pathogens, estimated that 71% of Pseudomonas aeruginosa isolates were identified by MALDI-TOF by day 2 of incubation, at which stage none had been identified by conventional culture2. Similarly, with Staphylococcus aureus, 89% were identified using MALDI-TOF by day 1 of incubation, whereas only 68% had been identified by culture on day 2. It can also identify bacteria which are slow growing much more quickly than by using standard culture techniques. In addition, it can also be used to identify yeasts and fungi, which are commonly found in CF patients. It can also determine differences between species of bacteria, such as those in the Burkholderia cepacia complex, which prove problematic for ...
Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families. Antarctica is one of the most extraordinary places on Earth and exhibits many distinctive features. Antarctic microorganisms are well known producers of valuable secondary metabolites. Specifically, several Antarctic strains have been reported to inhibit opportunistic human pathogens strains belonging to Burkholderia cepacia complex (Bcc). Herein, we applied a biodiscovery pipeline for the identification of anti-Bcc compounds. Antarctic sub-sea sediments were collected from the Ross Sea, and used to isolate 25 microorganisms, which were phylogenetically affiliated to three bacterial genera (Psychrobacter, Arthrobacter, and Pseudomonas) via sequencing and analysis of 16S rRNA genes. They were then subjected to a primary cell-based screening to determine their bioactivity against Bcc strains. Positive isolates were used to produce crude extracts from microbial
A no-rinse foam cleanser has been linked to at least 10 confirmed cases of Burkholderia cepacia complex; Shadow Holdings dba Bocchi Laboratories has voluntarily recalled the product as the FDA investigates.
Burkholderia cepacia is a gram negative bacilli usually isolated from persons with genetic lung diseases such as Cystic fibrosis. It was discovered as a plant pathogen but later researchers have found it to be a notorious pathogen in humans. It is also a nosocomial pathogen which contaminates equipment and even disinfectants. In the other end of the spectrum, research suggests that these organisms maybe used as bio diesel and also as pesticides and fertilizers. This review of literature gives an idea of the organism and the gateway it opens for further research with a special note on the evolution of this genus as a nosocomial infection in Neonates.
We are always amazed and extremely grateful when people go out of their way to raise money for cystic fibrosis services. Some people are motivated by a family member or friend living with CF, and some people have heard about the disease in the press and offer to help.. Find Out More ...
In this first phase of the project we focused our efforts to express the B. cepacia lipase in E.coli using the T7 promoter to obtain a constitutive expression of the gene. Also, we plan to conduct some experiments using the protein OmpA in order to evaluate its effect on the secretion levels of our lipase.Evaluation of the level of expression of the gene (lipase) will be done by means of RT-PCR in real time which allows us to select the best parameters for its massive production.. To evaluate, qualitatively, the bioactivity of the lipase, solid media with egg yolk were prepared. We expect to observe a degradation ring around the colonies expressing T7+lipase and T7+OmpA+lipase and a smaller or null ring around non-transformed cells. This is important since it will tell us if there are problems with the secretion of our protein and thus, evaluate if there are folding problems, problems with the signal peptide, formation of inclusion bodies or others.. ...
Re preferred amongst saturated AHL molecules, whilst OCHSL and OCHSL are for carbonyl group.Similarly, for hydroxyl group OHCHSL and OHCHSL are favored.As opposed to bacteria, archaea have uncommon AHLs i.e.carboxylatedHSLs.Formation of biofilm is definitely the representative outcome of intricate Boldenone Cypionate supplier patterns of communication to enhance pathogenicity of bacteria.Within a classical instance, two bacterial species Pseudomonas aeruginosa and Burkholderia cepacia are known to reside with each other within a biofilm PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21570335 in lungs of cystic fibrosis patients reflecting intraspecies, interspecies and interkingdom networking .Likewise, multispecies biofilms formed by several bacterial species involved in chronic wounds, dental plaque, and so on.exhibit complex networking among distinct organisms.This QS based groupbehavior of microbes is termed as `sociomicrobiology .SigMol can be a extensive resource of signaling molecules ...
The CF Center entrance is located in the Bernstein Pavilion between 15th and 16th Streets, facing Second Avenue. We are easily accessible by car and by public transportation.
FOSTER CITY, Calif., Feb 22, 2010 (BUSINESS WIRE) -- Gilead Sciences, Inc. (Nasdaq:GILD) today announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Cayston(R)(aztreonam for inhalation solution) as a treatment to improve respiratory symptoms in cystic fibrosis (CF) patients with Pseudomonas aeruginosa (P. aeruginosa). Caystons safety and efficacy have not been established in pediatric patients below the age of 7, patients with forced expiratory volume in one second (FEV1) of less than 25 percent or greater than 75 percent predicted, or patients colonized with Burkholderia cepacia. Cayston is administered at a dose of 75 mg three times daily over a 28-day period and is delivered via the Altera(R) Nebulizer System, a portable, drug-specific delivery device using the eFlow(R) Technology Platform, developed by PARI Pharma GmbH. PARI Pharma also contributed to the development of Caystons drug formulation for delivery with the Altera Nebulizer System. Cayston ...
Creating a news feed is your most valuable research tool. RelSci sends you actionable updates so you can keep tabs on the people and organizations you care about most.. ...
Lipases from Burkholderia cepacia (Amano PS) and Candida antarctica B (CalB) were immobilized by sol-gel entrapment techniques, using a ternary silane precursors system with vinyl and phenyl non-hydrolyzable groups. The influence of temperature on the catalytic properties of native and immobilized lipases was investigated by incubating the biocatalysts for 24 h at temperatures between 40 C and 80 C, in n-hexane medium. A long term stability study was made with immobilized CaLB biocatalysts by incubation for 120 h in isooctane at 80 C. The acylation of aliphatic sec-alcohols by vinyl acetate was used as model reaction. Thermogravimetric analysis (TGA) was employed to evaluate the thermal stability and degradation of the immobilized biocatalysts ...
Lipases from Burkholderia cepacia (Amano PS) and Candida antarctica B (CalB) were immobilized by sol-gel entrapment techniques, using a ternary silane precursors system with vinyl and phenyl non-hydrolyzable groups. The influence of temperature on the catalytic properties of native and immobilized lipases was investigated by incubating the biocatalysts for 24 h at temperatures between 40 C and 80 C, in n-hexane medium. A long term stability study was made with immobilized CaLB biocatalysts by incubation for 120 h in isooctane at 80 C. The acylation of aliphatic sec-alcohols by vinyl acetate was used as model reaction. Thermogravimetric analysis (TGA) was employed to evaluate the thermal stability and degradation of the immobilized biocatalysts ...
Lipase from Burkholderia cepacia (PS) has been immobilized on Accurel MP 1000, and their performance has been compared to that of the most widely used immobilized commercial preparation of this enzyme. The maximum loading was 18 mg protein/g support, and its thermal and solvent stability was much higher than that of the commercial. PS preparations were used in hydrolysis of triacetin and methyl mandelate, in the esterification of oleic acid and ethanol and in the kinetic resolution of 1,3,4-tri-O-benzyl-myo-inositol (DL-1) using vinylacetate as activated acyl donor. For all reactions studied, PS on Accurel was more active than PS-IM. The conversion in the kinetic resolution of racemic DL-1 was optimized using response surface methodology. Optimal conditions were determined to be 2.0 mg/mL of substrate, temperature of 40oC, 2.0 ml of vinyl acetate and without water addition. Under these conditions, maximum loaded Accurel-PS preparation permitted to improve the activity in this kinetic resolution ...
Enter the following information to request a copy of the document from the responsible person.. Interaction of Klebsiella oxytoca and Burkholderia cepacia in dual-species batch cultures and biofilms as a function of growth rate and substrate concentration. ...
Nurse Assist Inc. announced a recall of 386,175 Normal Saline Flush IV Syringes due to possible Burkholderia Cepacia contamination.
Insight Pharmaceuticals, LLC, has recalled the nasal spray Nostrilla Nasal Decongestant due to potential contamination with Burkholderia cepacia, according to an FDA MedWatch safety alert.
To learn more about these bacteria, researchers sequenced the genomes of 24 strains collected from 2010 to 2014. All of the B. cepacia and B. contaminans strains were highly similar, and likely descended from original populations of these two bacteria that were present in the water dispenser when it left Earth.. The researchers conclude that the two bacterial species living within the dispenser are no more dangerous than similar strains that might be encountered on Earth. In the event of an infection, the bacteria can still be treated with common antibiotics.. The authors add: Within each species, the 19 B. cepacia and 5 B. contaminans recovered from the ISS were highly similar on a whole genome scale, suggesting each population may have stemmed from two distinct founding strains. The differences that can be observed among the isolates of the same species are primarily located within putative plasmids. We find that the populations of Burkholderia present in the ISS PWS are likely are not more ...
Members who are not affiliated to an academic institution and/or cystic fibrosis centre do not have voting rights although, where appropriate, may be included in the consultation process.. ...
The CB021 embryonic stem cell (ESC) line was established from a cross between a B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax (APP/PS1) hemizygous female (MMRRC#|a href=http://jaxmice.jax.org/strain/005864.html|034832-JAX|/a|) and a C57BL/6 congenic male homozygous for |em|Mapt|sup|tm1(EGFP)Klt|/sup||/em|. This cell lines may be useful in in vitro experiments directed towards differentiation of ESCs to cortical neurons expressing AD-relevant mutations.
The SDSD is a database of the visual appearance of drug combinations reported in palliativedrugs.com prospective international multicentre surveys and also from individual reporting. There are currently over 2350 entries.This data is categorised as observational data, and a description of appeared compatible has been assigned if there was no obvious physical change in appearance of the combination in use, e.g. discoloration, clouding, or the precipitation of particles/crystals ...
https://www.npr.org/sections/coronavirus-live-updates/2021/05/29/1001590855/vietnam-detects-new-highly-transmissible-coronavirus-variant
The WHO declared the Delta strain as a variant of concern, and the CDC posted a new guideline after many vaccinated people got infected with the Delta variant. The study that the CDC revealed last month showed that both vaccinated and unvaccinated people produce similar amounts of virus when infected with the strain that originated in India.. The high viral load was responsible for an outbreak in Massachusetts, where 469 vaccinated people got infected after attending crowded events.The highly transmissible strain has also affected many businesses, especially in the entertainment and hospitality industries. A recent article mentions several notorious companies struggling to survive the pandemic. ...
C en 2002. Depuis 2008, le nombre de cas confirmés par le CNR sest stabilisé autour dune centaine de cas/an, soit 96 cas en 2017 et une incidence estimée à 0,85 cas confirmés/100.000 habitants. En 2017, le .... ...
Hello there everyone. I am writing to see if anyone has or had the same problems I have been having. I am 27 and have CF w/b.cepacia. Over this summer...
Pseudomonas cepacia, a.k.a. Burkholderia cepacia. Nocardia. Fungi Aspergillus species. Aspergillus has a propensity to cause ... "Chronic granulomatous disease presenting in childhood with Pseudomonas cepacia septicaemia". The Journal of Infection. 27 (3): ...
Burkholderia cepacia:Friend or Foe? - Jennifer L. Parke Annual Review of Microbiology Annual Review of Phytopathology Some ... Bacterial strains from the Burkholderia cepacia complex (Bcc) are opportunistic pathogens in humans with cystic fibrosis and ... In 1950 he first described the bacteria, Pseudomonas cepacia, later Burkholderia spp., responsible for causing sour skin ...
"Burkholderia cepacia and cystic fibrosis". Archived from the original on 2008-09-16. Retrieved 2008-08-15.. ... Genomovar is a term commonly used within the genera Burkholderia and Agrobacterium to denote strains which are phylogenetically ...
Burkholderia cepacia • Campylobacter jejuni • Capnocytophaga ochracea • Corynebacterium xerosis • Enterobacter cloacae • ...
The non-sterile form of Povidone iodine has a long history of intrinsic contamination with Burkholderia cepacia (aka ... Rose H, Baldwin A, Dowson CG, Mahenthiralingam E (March 2009). "Biocide susceptibility of the Burkholderia cepacia complex". ... Pseudomonas cepacia), and other opportunistic pathogens. Its ability to harbor such microbes further underscores the importance ...
Weinstein, Lenny; Knowlton, Christin A.; Smith, Miriam A. (2007-12-16). "Cervical osteomyelitis caused by Burkholderia cepacia ... The Burkholderia cepacia complex has been implicated in vertebral osteomyelitis in intravenous drug users. In general, ...
Burkholderia cepacia Proteus mirabilis and P. vulgaris Enterobacter spp. Bacteroides spp. Fusobacterium spp. Notable organisms ...
LiPuma JJ, Spilker T, Coenye T, Gonzalez CF (June 2002). "An epidemic Burkholderia cepacia complex strain identified in soil". ...
Brucella Burkholderia cepacia Chryseobacterium indologenes Edwardsiella Elizabethkingia meningoseptica Francisella tularensis ...
Burkholderia cepacia strain AIMST Ngse1 16S ribosomal RNA gene, partial sequence. NCBI. Burkholderia multivorans strain AIMST ... Burkholderiaceae Burkholderia Burkholderia cepacia strain AIMST Ngse1 (N. gracilis; Selangor, Malaysia; leaf tissue) ... Burkholderia multivorans strain AIMST Ngse2 (N. gracilis; Selangor, Malaysia; leaf tissue) Enterobacteriaceae Citrobacter ...
Sajjan US, Sylvester FA, Forstner JF (2000). "Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells ...
"Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100". Journal of Bacteriology. ...
"Factors Influencing Acquisition of Burkholderia Cepacia Complex Organisms in Patients with Cystric Fibrosis". Journal of ...
Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia are found most often in cystic fibrosis patients. High- ...
"Influence of Pseudomonas aeruginosa Exoproducts on Virulence Factor Production in Burkholderia cepacia: Evidence of ...
"Influence of Pseudomonas aeruginosa Exoproducts on Virulence Factor Production in Burkholderia cepacia: Evidence of ... P. aeruginosa exoproducts help B. cepacia to attach to different surfaces. The New Scientist: Lab chimp speaks his own language ...
... of Burkholderia cepacia AC1100". Journal of Bacteriology. 185 (9): 2786-92. doi:10.1128/jb.185.9.2786-2792.2003. PMC 154418. ... H+ The enzyme from Burkholderia phenoliruptrix has a preference for FAD. Gisi MR, Xun L (May 2003). "Characterization of ...
"A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence". ... archaea and a number of pathogenic bacteria including Burkholderia cenocepacia, Neisseria gonorrhoeae and Acinetobacter ...
One particular method is the use of the bacterial complex Burkholderia cepacia, which is a registered control method. This ...
Meanwhile, some Burkholderia cepacia, Clostridium innocuum and Enterococcus faecium strains have developed resistance to ...
Burkholderia cepacia bacteria was found on some equipment which, according to Johnson & Johnson, never was actually put into ...
Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for clinical isolation of Burkholderia pseudomallei ... Ashdown's medium is a selective culture medium for the isolation and characterisation of Burkholderia pseudomallei (the ... 2007). "Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei". J Bacteriol. 189 (3 ...
... with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. Nov". Microbiology and Immunology. 36 (12): 1251- ... cepacia, P. cocovenenans, P. delafieldii, P. facilis, P. flava, P. gladioli, P. glathei, P. glumae, P. graminis, P. huttiensis ... "Characterization of PCR-ribotyping for Burkholderia (Pseudomonas) cepacia". Journal of Clinical Microbiology. 32 (10): 2422- ... Yabuuchi, E.; Kosako, Y.; Yano, I.; Hotta, H.; Nishiuchi, Y. (1995). "Transfer of two Burkholderia and an Alcaligenes species ...
... carbon-phosphorus bond cleavage enzyme in Burkholderia cepacia Pal6". Arch. Microbiol. 173 (1): 35-41. doi:10.1007/ ...
For laboratories located outside endemic areas, Burkholderia cepacia selective agar or Pseudomonas selective agar can be used ... Exposure to Burkholderia pseudomallei may commonly cause antibodies to be produced against it without any symptoms. Of the ... Gee JE, Gulvik CA, Elrod MG, Batra D, Rowe LA, Sheth M, Hoffmaster AR (July 2017). "Phylogeography of Burkholderia pseudomallei ... January 2016). "Burkholderia pseudomallei and burden of melioidosis". Nature Microbiology. 1 (1): 15008. doi:10.1038/nmicrobiol ...
"Therefore, any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ...
It is normally active against Moraxella catarrhalis, Brucella abortus, Burkholderia cepacia, Citrobacter species, Escherichia ...
... და ზოგჯერ Burkholderia cepacia). 18 წლის ასაკისთვის პაციენტების 80% P. aeruginosa-ს სამიზნე ხდება, ხოლო 3.5%-ში B. cepacia-სი.[ ... Burkholderia) cepacia and multiresistant Pseudomonas aeruginosa". Neth J Med 46 (6): 280-87. . PMID 7643943. ... "Pseudomonas cepacia at summer camps for persons with cystic fibrosis". MMWR Morb. Mortal. Wkly. Rep. 42 (23): 456-9. June 1993 ... Pegues DA, Carson LA, Tablan OC, FitzSimmons SC, Roman SB, Miller JM, Jarvis WR (May 1994). "Acquisition of Pseudomonas cepacia ...
Seven of the most common contaminants are: Aspergillus niger Burkholderia cepacia Clostridium difficile Escherichia coli ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei (Melioidosis) · Burkholderia mallei (Glanders) · Burkholderia cepacia complex · Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for clinical isolation of Burkholderia pseudomallei ... 2011). "Rapid identification of Burkholderia pseudomallei and Burkholderia mallei by fluorescence in situ hybridization (FISH) ... Pathema Burkholderia resource "Burkholderia pseudomallei". NCBI Taxonomy Browser. 28450. ... or Burkholderia cepacia medium) may be used for selective isolation. Cultures typically become positive in 24 to 48 hours (this ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
... some Burkholderia cepacia, Clostridium innocuum and Enterococcus faecium strains have developed resistance to ciprofloxacin to ...
... with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. Nov". Microbiology and immunology 36 (12): 1251- ... cepacia, P. cocovenenans, P. delafieldii, P. facilis, P. flava, P. gladioli, P. glathei, P. glumae, P. graminis, P. huttiensis ... Yabuuchi, E.; Kosako, Y.; Yano, I.; Hotta, H.; Nishiuchi, Y. (1995). "Transfer of two Burkholderia and an Alcaligenes species ... outras cepas antes clasificadas no xénero Pseudomonas están agora clasificadas no xénero Burkholderia e Ralstonia.[12][13] ...
Burkholderia infection usually Burkholderia cepacia and other Burkholderia species Buruli ulcer Mycobacterium ulcerans ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
"Therefore, any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia ... "Infection with Aspergillus, Burkholderia Cepacia, Serratia Marcescens, Nocardia should prompt work up for CGD". Chronic ... "Infection with Aspergillus, Burkholderia Cepacia, Serratia Marcescens, Nocardia should prompt work up for CGD". Chronic ... "Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
Burkholderia pseudomallei *Melioidosis. *Burkholderia mallei *Glanders. *Burkholderia cepacia complex. *Bordetella pertussis/ ...
nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia ... "Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. ... B. arboris belongs to the Burkholderia cepacia complex. "J.P. Euzéby: List of bacterial names with standing in nomenclature". " ... Burkholderia arboris is a Gram-negative, aerobic, non-spore-forming bacterium of the genus Burkholderia and the family ...
... a defunct industry standards organization Burkholderia cepacia complex, a bacterial pathogen Business Controls Corporation, ...
Two bacterial isolates, Burkholderia cepacia(B3) and Pseudomonas aeruginosa(P3) were selected for evaluation in the glasshouse ...
General Information about B. cepacia. Burkholderia cepacia [burk-hōld-er-ee-uh si-pay-shee-uh] (also called B. cepacia) is the ... B cepacia is a known cause of infections in hospitalized patients.. Symptoms of B. cepacia infection. The effects of B. cepacia ... B. cepacia bacteria are often resistant to common antibiotics.. Populations susceptible to B. cepacia infection. B. cepacia ... Exposure to B. cepacia in the environment.. Treatment of B. cepacia infection. B. cepacia can be resistant to many common ...
Burkholderia cepacia complex in the NCBI Taxonomy Browser Type strain of Burkholderia cepacia complex at BacDive, the Bacterial ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ... The organism is usually cultured in Burkholderia cepacia agar (BC agar), which contains crystal violet and bile salts to ... Frost, F; Shaw, M; Nazareth, D (June 13, 2019). "Antibiotic therapy for chronic infection with Burkholderia cepacia complex in ...
The multifarious, multireplicon Burkholderia cepacia complex.. Mahenthiralingam E1, Urban TA, Goldberg JB. ... The Burkholderia cepacia complex (Bcc) is a collection of genetically distinct but phenotypically similar bacteria that are ... cepacia syndrome, which is characterized by a rapid decline in lung function that can include invasive disease. Here we ... Burkholderia cepacia complex/genetics*. *Burkholderia cepacia complex/pathogenicity*. *Burkholderia cepacia complex/physiology ...
Detection of Pseudomonas (Burkholderia) cepacia using PCR.. Campbell PW 3rd1, Phillips JA 3rd, Heidecker GJ, Krishnamani MR, ... We designed a PCR method to detect P. cepacia using P. cepacia 16 S rRNA sequences as the amplification target region. The PCR ... When sputum samples from three CF patients chronically colonized with P. cepacia and P. aeruginosa were analyzed, P. cepacia ... Pseudomonas cepacia colonization of the lung is associated with increased morbidity and mortality for cystic fibrosis (CF) ...
B cepacia,/i, genomovars, and consequently further segregation between genomovar III and non-genomovar III B cepacia infected ... Burkholderia cepacia,/i, complex infections in cystic fibrosis (CF) has recently been ascribed to differences in the virulence ... Cepacia-Like Syndrome Caused by Burkholderia mutivorans. George Zahariadis. ,1 Michelle H Levy. ,2 and Jane L Burns3. 1 ... Cepacia-Like Syndrome Caused by Burkholderia mutivorans,. Canadian Journal of Infectious Diseases and Medical Microbiology,. ...
Control of Cotton Seedling Damping-off in the Field by Burkholderia (Pseudomonas) cepacia. K. Zaki, I. J. Misaghi, and A. ... Related articles on Burkholderia cepacia from APS Journals. Mobilization, Cloning, and Sequence Determination of a Plasmid- ... Encoded Polygalacturonase from a Phytopathogenic Burkholderia (Pseudomonas) cepacia. Carlos F. Gonzalez, Elizabeth A. Pettit, ...
Multistate Outbreak of Burkholderia cepacia Infections Associated with Contaminated Ultrasound Gel ... Multistate Outbreak of Burkholderia cepacia Infections Associated with Contaminated Ultrasound Gel. ... due to risk of bacterial contamination with Burkholderia cepacia complex. FDAs new guidance expands upon Eco-Meds voluntary ... and several state and local health departments with an ongoing investigation of Burkholderia cepacia complex (Bcc) infections ...
Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis and Burkholderia cepacia genomovars I and III. J ... Burkholderia cepacia: Friend or Foe?. Parke, J.L. 2000. Burkholderia cepacia: Friend or Foe? The Plant Health Instructor. DOI: ... Burkholderia cepacia genomovar VI, a new member of the Burkholderia cepacia complex isolated from cystic fibrosis patients. Int ... Proposal to accommodate Burkholderia cepacia genomovar VI as Burkholderia dolosa sp. nov. Int J Syst Evol Microbiol 54:689-691. ...
... we present a case of Burkholderia cepacia complex cervical osteomyelitis in an intravenous drug user. Burkholderia cepacia ... Burkholderia cepacia complex Cervical Osteomyelitis in an Intravenous Drug User. Sui Kwong Li1 and William B. Messer1,2 ... Burkholderia cepacia complex are closely related aerobic Gram-negative bacilli that are well described in infections among ... Burkholderia cepacia complex vertebral osteomyelitis is an infrequently described clinical syndrome in the literature though it ...
... multireplicon Burkholderia cepacia complex." Nature. 3 Hua, C.N.C., Tokeshi, J. "Emergence of Burkholderia cepacia in Honolulu ... 6 "Burkholderia cepacia in Healthcare Settings." Centers for Disease Control and Prevention. 7 Gilchrist, F.J., Webb, A.K., ... This is often referred to as the Burkholderia cepacia complex (BCC) [1][2]. It was originally recognized by W. H. Burkholder in ... Burkholderia cepacia complex. From MicrobeWiki, the student-edited microbiology resource. Revision as of 21:03, 10 February ...
Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application: ... Genomic DNA from Burkholderia cepacia strain 249 [ATCC® 17616™] Biosafety Level 1 Biosafety classification is based on U.S. ... Burkholderia cepacia (Palleroni and Holmes) Yabuuchi et al. (ATCC® 17616D-5™) Strain Designations: Genomic DNA from ... Nucleotide (GenBank) : AY741333 Burkholderia cepacia strain ATCC 17616 16S ribosomal RNA gene, partial sequence ...
Burkholderia cepacia ATCC ® 25416™ Designation: UCB 717 TypeStrain=True Application: Assay of antimicrobial preservatives Media ... Burkholderia cepacia 16S ribosomal RNA gene, partial sequence. Nucleotide (GenBank) : AJ293344 Burkholderia cepacia partial ... Burkholderia cepacia (Palleroni and Holmes) Yabuuchi et al. (ATCC® 25416™) Strain Designations: UCB 717 [717-ICPB 25, Ballard ... Pyrimidine synthesis in Burkholderia cepacia ATCC 25416. Lett Appl Microbiol 21: 340-343, 1995. PubMed: 7576530 ...
... and biological pesticide Burkholderia cepacia because EPA canceled food registrations or deleted food uses from registrations ... 3. Burkholderia cepacia type Wisconsin. On August 28, 2002 (67 FR 55236) (FRL-7189-4), EPA published a notice in the Federal ... Allethrin, Bendiocarb, Burkholderia cepacia, Fenridazon potassium, and Molinate; Tolerance Actions. A Rule by the Environmental ... EPA is revoking the tolerance exemption in 40 CFR 180.1115 for residues of Burkholderia cepacia type Wisconsin in or on all raw ...
Human (hBD-1) and murine (mBD-1) b-defensins were examined for activity against B. cepacia. In contrast to the salt-sensitive ... The susceptibility of the B. cepacia strain panel to plant extracts was investigated, in particular the activity of aqueous ... The project focused on a panel of 20 strains of B. cepacia complex. Isolates included strains representing major epidemic ... In contrast, two hours incubation with AGE produced morphological changes in the cellular structure of B. cepacia consistent ...
Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health ... Identification and population structure of Burkholderia stabilis sp. nov. (formerly Burkholderia cepacia genomovar IV). J Clin ... cepacia+complex+isolates+in+human...-a0161011310. *APA style: Environmental Burkholderia cepacia complex isolates in human ... Commercial use of Burkholderia cepacia. Emerg Infect Dis. 1999;5:305-6. (9.) Govan JRW, Balendreau J, Vandamme P. Burkholderia ...
The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence ... Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada Emerg Infect Dis. 2002 Feb;8(2):181-7. ... The Burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (CF). Although evidence ... cepacia complex from genomovar III are the most potentially transmissible and that the B. cepacia epidemic strain marker is a ...
What is Burkholderia cepacia? Meaning of Burkholderia cepacia medical term. What does Burkholderia cepacia mean? ... Looking for online definition of Burkholderia cepacia in the Medical Dictionary? Burkholderia cepacia explanation free. ... Burkholderia cepacia. Burkholderia cepacia. a bacterial species found in rotted onions and in clinical specimens; commonly ... Synonym(s): Pseudomonas cepacia. Burkholderia cepacia. formerly Pseudomonas cepacia. A group of bacteria found in the ...
The Burkholderia cepaciacomplex (Bcc) is a group of 17 closely related species of the β-proteobacteria subdivision that emerged ... nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia ... Saldías MS, Valvano MA (2009) Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with ... a complex within the Burkholderia cepacia complex comprises at least two novel species: Burkholderia contaminans sp. nov. and ...
... of Burkholderia cepacia AC1100.. Webb, B.N., Ballinger, J.W., Kim, E., Belchik, S.M., Lam, K.S., Youn, B., Nissen, M.S., Xun, L ... Burkholderia cepacia AC1100 completely degrades 2,4,5-trichlorophenol, in which an FADH(2)-dependent monooxygenase (TftD) and ... Burkholderia cepacia AC1100 completely degrades 2,4,5-trichlorophenol, in which an FADH(2)-dependent monooxygenase (TftD) and ... Crystal Structure of Chlorophenol 4-Monooxygenase (TftD) of Burkholderia cepacia AC1100. *DOI: 10.2210/pdb3HWC/pdb ...
Burkholderia mallei, Burkholderia pseudomallei,Burkholderia gladioli, Burkholderia plantarii,Burkholderia glumae, Burkholderia ... Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III. J. ... Burkholderia ubonensis, Burkholderia caledonica, Burkholderia fungorum,Burkholderia stabilis, and Burkholderia ambifaria(1, 10 ... 2001) Burkholderia cepacia genomovar VI, a new member of the Burkholderia cepacia complex isolated from cystic fibrosis ...
Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). ... Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). ... Salicylate is an important siderophore produced by B. cepacia complex isolates, and both extrinsic salicylate and iron ... and ciprofloxacin has been identified in Burkholderia cenocepacia (genomovar III), an important cystic fibrosis pathogen. Five ...
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline ... Azithromycin in Patients With CF, Infected With Burkholderia Cepacia Complex. The recruitment status of this study is unknown. ...
Burkholderia cepacia (Pseudomonas cepacia). 231. UniRef90_Q51645. Cluster: (S)-2-haloacid dehalogenase 4A. 3. ... Burkholderia cepacia (Pseudomonas cepacia). Paraburkholderia oxyphila. 231. UniRef50_Q51645. Cluster: (S)-2-haloacid ... Burkholderia cepacia (Pseudomonas cepacia). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_ ... sp,Q51645,HAD4_BURCE (S)-2-haloacid dehalogenase 4A OS=Burkholderia cepacia OX=292 GN=hdl IVa PE=1 SV=3 ...
B cepacia complex strains may remain endemic in CF treatment centers for many years. Responsible bacterial and host factors and ... Endemicity and inter-city spread of Burkholderia cepacia genomovar III in cystic fibrosis J Pediatr. 2001 Nov;139(5):643-9. doi ... Objectives: We sought to determine whether the same Burkholderia cepacia complex strain has persisted as the dominant clonal ... Conclusions: B cepacia complex strains may remain endemic in CF treatment centers for many years. Responsible bacterial and ...
... a colonização por Burkholderia cepacia complex (BCC), sobretudo... ... Colonização por Burkholderia cepacia complex em pacientes com doença pulmonar supurativa submetidos ao transplante pulmonar: ... Burkholderia Cepacia Complex colonization in patients with suppurative lung disease undergoing lung transplantation: impact on ... a colonização por Burkholderia cepacia complex (BCC), sobretudo o genomovar III, vem sendo relacionada a pior prognóstico e, ...
Vandamme P, Holmes B, Vancanneyt M, Coenye T, Hoste B, Coopman R, Occurrence of multiple genomovars of Burkholderia cepacia in ... Agricultural use of Burkholderia (Pseudomonas) cepacia: a threat to human health? Emerg Infect Dis. 1998;4:221-7. DOIPubMed ... To the Editor: In their review of the potential threat to human health by the commercial use of Burkholderia cepacia, Holmes et ... LiPuma, J. J., & Mahenthiralingam, E. (1999). Commercial Use of Burkholderia cepacia. Emerging Infectious Diseases, 5(2), 305- ...
Burkholderia cepacia IBSD-LKBI exhibited the highest plant growth promotion and BCA. After 60 days of treatment, plant height, ... P Burkholderia cepacia (98%). Multiple sequence alignment & phylogram with closely related sequence accessions using MEGA ... Software revealed this naturally occurring biocontrol bacteria belongs to Burkholderia cepacia complex genomovar I based on the ... Burkholderia cepacia IBSD-LKBI exhibited the highest plant growth promotion and BCA. After 60 days of treatment, plant height, ...
Burkholderia cepacia (previously Pseudomonas cepacia) is an important pathogen in patients with cystic fibrosis (23). Twenty ... 1997) Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia ... Quorum Sensing in Burkholderia cepacia: Identification of the LuxRI Homologs CepRI. Shawn Lewenza, Barbara Conway, E. P. ... Quorum Sensing in Burkholderia cepacia: Identification of the LuxRI Homologs CepRI. Shawn Lewenza, Barbara Conway, E. P. ...
The Burkholderia cepacia complex consists of nine closely related species: Burkholderia cepacia genomovars I and VI, ... Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound ... Updated Version of the Burkholderia cepacia Complex Experimental Strain Panel. Tom Coenye, Peter Vandamme, John J. LiPuma, John ... Updated Version of the Burkholderia cepacia Complex Experimental Strain Panel. Tom Coenye, Peter Vandamme, John J. LiPuma, John ...
... cepacia may be the offending organism resulting in a postoperative lumbar PS.PMID:33948309 , PMC:PMC8088530 , DOI:10.25259/SNI_ ... Of onions and men: Report of cavitary community acquired pneumonia due to Burkholderia cepacia complex in an immunocompetent ... Genome sequence-based curation of PubMLST data challenges interspecies recombination in the Burkholderia cepacia complex ... Lipopolysaccharide perception in Arabidopsis thaliana: Diverse LPS chemotypes from Burkholderia cepacia, Pseudomonas syringae ...
  • Specifically, genomovar III isolates have been associated with higher transmission rates and adverse outcomes compared to other B cepacia genomovars, and consequently further segregation between genomovar III and non-genomovar III B cepacia infected patients is advocated in some centres. (hindawi.com)
  • Environmental Burkholderia cepacia complex isolates in human infections. (thefreelibrary.com)
  • it is therefore unclear to what category the presumed B. cepacia isolates described would belong. (asm.org)
  • Salicylate is an important siderophore produced by B. cepacia complex isolates, and both extrinsic salicylate and iron starvation appear to upregulate ceoR promoter activity, as does chloramphenicol. (jci.org)
  • We analyzed all available B cepacia complex isolates recovered from 1981 to 1987 and from 1996 to 2000 at one large CF treatment center (Center A) and from 1997 to 2000 at another center (Center B). Incidence of B cepacia complex infection and infection control measures in both centers were assessed. (nih.gov)
  • All 11 Belgian health facilities caring for CF patients agreed to participate in the current study and to send all B. cepacia -like isolates to the reference laboratory between February 1999 and February 2000. (ersjournals.com)
  • Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. (asm.org)
  • These results suggest that the numbers and types of siderophores produced by CF isolates of B. cepacia correlate with RAPD type and that SA and ornibactins are the most prevalent siderophores produced. (asm.org)
  • In a previous study of 43 B. cepacia isolates from CF patients from Toronto and Cleveland, 49% were found to produce pyochelin ( 18 ). (asm.org)
  • B. cepacia isolates that do not produce pyochelin were shown to utilize pyochelin for growth and iron transport. (asm.org)
  • SA, originally termed azurechelin, was previously reported to be produced by 88% of B. cepacia respiratory isolates from CF patients ( 19 , 22 ). (asm.org)
  • however, there have been no reports describing the production of cepabactin in clinical isolates of B. cepacia ( 13 , 14 ). (asm.org)
  • We have shown that pyochelin and SA are commonly produced by B. cepacia respiratory isolates from CF patients ( 18 , 19 ) and that they may play a role as virulence factors in these infections. (asm.org)
  • repetitive-element polymerase chain reaction (PCR)-mediated molecular fingerprinting on eight patient isolates and three environmental B. cepacia isolates that were available for study. (annals.org)
  • Molecular fingerprints of patient isolates and environmental B. cepacia isolates were identical using repetitive-element PCR. (annals.org)
  • No further isolates of B. cepacia were identified after institution of appropriate infection control procedures. (annals.org)
  • This sugar nucleotide is the intermediary necessary for the biosynthesis of GDP-D-rhamnose, one of the sugar residues of cepacian, the major exopolysaccharide produced by environmental and human, animal and plant pathogenic isolates of the Burkholderia cepacia complex species. (sigmaaldrich.com)
  • B. cepacia complex isolates are frequently misidentified in the clinical laboratory by conventional manual biochemical or automated testing methods. (antimicrobe.org)
  • b Includes (number of isolates) Burkholderia contaminans (11), Burkholderia dolosa (10), Burkholderia ambifaria (9), and Burkholderia stabilis (9). (asm.org)
  • PCR and restriction fragment length polymorphism (RFLP) typing of flagellin genes ( fli C) from 57 clinical isolates of Burkholderia cepacia indicated that only type II flagellins were present. (microbiologyresearch.org)
  • Contains data for a collection of isolates that represent the total known diversity of the Burkholderia cepacia complex. (pubmlst.org)
  • Integrated genotypic and phenotypic analyses have shown that B. cepacia isolates, cultured from clinical or environmental sites, belong to at least five distinct genomic species or genomovars, referred to collectively as the B. cepacia complex. (apsnet.org)
  • Separately, the Burkholderia cepacia isolates from seven of the nine patients were found to be genetically identical upon laboratory testing. (outbreaknewstoday.com)
  • According to biochemical tests and Vitek-2 system B. cepacia were occurred in 16/985(1.624%), these isolates were distributed as following 6(2.5%), 4(7.272%), 3(1.071%), 2(5%) and 1(1.428%) from Burn and wound, diabetic foot ulcer, blood, cerebrospinal fluid. (ejobios.org)
  • The 15 STs identified from environmental and clinical sources belonged to 6 different Bcc species (Table): B. cepacia (4 STs), B. multivorans (2 STs), B. cenocepacia (3 STs), B. stabilis (2 STs), B. vietnamiensis (2 STs), and B. ambifaria (2 STs). (thefreelibrary.com)
  • Agnoli K, Lowe CA, Farmer KL, Husnain SI, Thomas MS (2006) The ornibactin biosynthesis and transport genes of Burkholderia cenocepacia are regulated by an extracytoplasmic function s factor which is a part of the Fur regulon. (springer.com)
  • Bernier SP, Sokol PA (2005) Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia . (springer.com)
  • Bernier SP, Nguyen DT, Sokol PA (2008) A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence. (springer.com)
  • Bylund J, Burgess LA, Cescutti P, Ernst RK, Speert D (2006) Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species. (springer.com)
  • An antibiotic efflux gene cluster that confers resistance to chloramphenicol, trimethoprim, and ciprofloxacin has been identified in Burkholderia cenocepacia (genomovar III), an important cystic fibrosis pathogen. (jci.org)
  • Burkholderia cepacia genomovars I and VI, Burkholderia multivorans (genomovar II), Burkholderia cenocepacia (genomovar III), Burkholderia stabilis (genomovar IV), Burkholderia vietnamiensis (genomovar V), Burkholderia ambifaria (genomovar VII), Burkholderia anthina (genomovar VIII), and Burkholderia pyrrocinia (genomovar IX) ( 2 , 9 , 10 ). (asm.org)
  • The impact of Burkholderia cepacia complex on morbidity in the Belgian cystic fibrosis population is high and not limited to Burkholderia cenocepacia . (ersjournals.com)
  • Effects of extended storage of chlorhexidine gluconate and benzalkonium chloride solutions on the viability of Burkholderia cenocepacia. (eurosurveillance.org)
  • This work reports the biochemical and functional analysis of the Burkholderia cenocepacia J2315 bceN gene, encoding a protein with GDP-D-mannose 4,6-dehydratase enzyme activity (E.C.4.2.1.47). (sigmaaldrich.com)
  • Burkholderia cenocepacia is the most prominent species of the B. cepacia complex (Bcc), a group of nine closely related and difficult to identify bacteria that cause serious infections in patients with cystic fibrosis. (biomedcentral.com)
  • Burkholderia cenocepacia is a member of the B. cepacia complex (Bcc), a group of opportunistic bacteria that infect the airways of patients with cystic fibrosis (CF) and are extraordinarily resistant to almost all clinically useful antibiotics. (microbiologyresearch.org)
  • Other species such as Burkholderia multivorans have also been associated with 'cepacia syndrome' (Blackburn et al, 2004) and some, such as Burkholderia dolosa appear as invasive in vitro as B. cenocepacia (Caraher et al, 2007). (cysticfibrosis.online)
  • Cystic fibrosis outbreak strains (Burkholderia multivorans Glasgow strain and Burkholderia cenocepacia ET12) possessed elevated chlorhexidine resistance, and Bcc bacteria were also shown to remain viable in current commercial biocide formulations. (warwick.ac.uk)
  • MALDI-TOF MS identified 2 species of Bcc (B. cenocepacia and B. cepacia). (cdc.gov)
  • B. cepacia complex organisms have also been the focus of considerable research by plant pathologists who have shown that some strains are effective biocontrol agents against soilborne (7-11), foliar (12), and post-harvest diseases (13-15). (apsnet.org)
  • Many strains of the B. cepacia complex produce one or more antibiotics active against a broad range of plant pathogenic fungi (16,17). (apsnet.org)
  • Several B. cepacia complex strains have in the past been registered by the U.S. EPA for use as microbial pesticides (biological control agents). (apsnet.org)
  • Some scientists are concerned about the use of B. cepacia complex bacteria for biocontrol because certain strains are opportunistic human pathogens. (apsnet.org)
  • B. cepacia complex organisms are responsible for some nosocomial (hospital-derived) infections, and most alarmingly, some strains can cause fatal lung infection of individuals with cystic fibrosis (CF) (18). (apsnet.org)
  • Currently, it is not possible to determine strains of B. cepacia that can be safely used in agriculture without potentially harming humans, which causes discourse between the scientific and agricultural communities [4] . (kenyon.edu)
  • Cardona ST, Wopperer J, Eberl L, Valvano MA (2005) Diverse pathogenicity of Burkholderia cepacia complex strains in the Caenorhabditis elegans host model. (springer.com)
  • The name B. cepacia will relate only to B. cepacia genomovar I. Strains resembling B. cepacia may belong to the B. cepacia complex, to other Burkholderia species (for instance, Burkholderia gladioli ), or to species from other genera (for instance, Ralstonia pickettii ) that share some phenotypic or genotypic similarities with the B. cepacia complex. (asm.org)
  • This was confirmed by several studies ( 34 , 64 , 67 , 76 , 84 , 94 ) that showed that " B. cepacia " strains can spread between CF patients via simultaneous hospital admissions or social contact outside of the hospital. (asm.org)
  • B cepacia complex strains may remain endemic in CF treatment centers for many years. (nih.gov)
  • B . cepacia complex strains have also attracted attention as possible biocontrol and bioremediation agents that could be used as antagonists of soil-borne plant pathogens, as plant growth-promoting agents, and for the bioremediation of various recalcitrant xenobiotics ( 3 , 8 ). (asm.org)
  • To aid in identification, epidemiological tracking, and virulence studies, a set of strains representative of the first five known genomovars of the B . cepacia complex was assembled ( 7 ). (asm.org)
  • Four B . cepacia genomovar VI strains are included in the panel. (asm.org)
  • Remarkable heterogeneity among presumed B. cepacia strains and the lack of reliable identification schemes makes correct identification of B. cepacia colonisation a complex problem 5 , 6 . (ersjournals.com)
  • We performed an integrated genotypic and phenotypic analysis of 128 strains of the genera Burkholderia, Ralstonia, and Pseudomonas in order to study the taxonomic structure of Burkholderia cepacia and its relationships with other Burkholderia species. (nih.gov)
  • Our data show that presumed B. cepacia strains isolated from cystic fibrosis patients belong to at least five distinct genomic species, one of which was identified as Burkholderia vietnamiensis. (nih.gov)
  • Whole-genome sequencing detected genetically identical B. cepacia complex strains in patient samples, from a batch of octenidine mouthwash solution, which had been used for nursing care, as well as in samples obtained from the manufacturer during production. (eurosurveillance.org)
  • Differences in levels of severity of B. cepacia infections in CF patients have been noted, and these may be due to variation in the types of virulence factors expressed among strains. (asm.org)
  • In a subsequent study using a rat model of chronic pulmonary infection, exogenously supplied pyochelin was shown to increase the virulence of B. cepacia pyochelin-negative strains ( 20 ). (asm.org)
  • More recently, B. cepacia strains have also been reported to produce linear hydroxamate or hydroxycarboxylate siderophores, termed ornibactins ( 21 ). (asm.org)
  • Although B. cepacia complex strains are frequently isolated from the natural environment, common environmental species are infrequently associated with human infection. (antimicrobe.org)
  • Transmission of B. cepacia complex among cystic fibrosis patients has been reduced in recent years by stringent infection prevention and control efforts, supported by the finding that the majority of new B. cepacia complex infections involve acquisition of unique strains likely from independent environmental sources ( 63 ). (antimicrobe.org)
  • Exposing the third chromosome of Burkholderia cepacia complex strains as a virulence plasmid," MOLECULAR MICROBIOLOGY , vol. 83, no. 2, pp. 362-378, 2011. (ugent.be)
  • Distribution of MICs of ceftolozane-tazobactam, ceftazidime, and meropenem for 221 Burkholderia strains. (asm.org)
  • AiiA lactonase, we show that expression of antifungal activities is AHL-dependent in the large majority of the investigated strains belonging to various Burkholderia species. (uzh.ch)
  • We demonstrate that in certain strains of Burkholderia ambifaria, Burkholderia pyrrocinia and Burkholderia lata, one of the QS-regulated antifungal agents is pyrrolnitrin (prn), a common broad-spectrum antibiotic that is also produced by some Pseudomonas and Serratia species. (uzh.ch)
  • We will learn the state-of-the art in differentiating between human pathogenic, plant pathogenic, and non-pathogenic strains, and establish a dialogue among plant pathologists, medical microbiologists, and regulatory experts with regard to the prudent use of Burkholderia cepacia in agriculture. (apsnet.org)
  • Two strains of B. cepacia of environmental (NCTC 10661) and clinical origin (C1359) were examined for their ability to invade and survive (over a 24 h period) within type II pneumocytes in primary culture using a gentamicin¿ceftazidime antibiotic protection assay. (brad.ac.uk)
  • Both strains of B. cepacia were capable of invasion of type II pneumocytes in primary culture. (brad.ac.uk)
  • The Burkholderia cepacia complex (Bcc) is a collection of genetically distinct but phenotypically similar bacteria that are divided into at least nine species. (nih.gov)
  • The PCR amplification with purified DNA as template yielded the expected 209-bp products from P. cepacia, but not from related Pseudomonas species of medical importance or other bacteria which have been reported to colonize CF patients. (nih.gov)
  • The Burkholderia cepacia complex (Bcc) is a group of at least 9 closely related species (often called "genomovars") that is currently attracting considerable attention for their extraordinary versatility as plant pathogens, saprophytes, biocontrol agents, bioremediation agents, and human pathogens. (apsnet.org)
  • Indirect evidence for the speculation that the environment serves as a reservoir for acquisition of novel B. cepacia complex species comes from the observation that infection control measures (including segregation of patients) have reduced but not eliminated new infections. (apsnet.org)
  • Burkholderia cepacia complex is a group of Gram-negative, non-spore forming bacilli composed of approximately 17 closely-related species which are grouped into nine genomovars. (kenyon.edu)
  • Proposal of Burkholderia gen. nov. and transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. (atcc.org)
  • The Burkholderia cepacia complex (Bcc) is a group of closely related gram-negative bacteria comprising at least 9 species (1). (thefreelibrary.com)
  • The Burkholderia cepacia complex (Bcc) is a group of 17 closely related species of the β-proteobacteria subdivision that emerged in the 1980s as important human pathogens, especially to patients suffering from cystic fibrosis. (springer.com)
  • However, despite being nonpathogenic to healthy humans (and thus classified as a Biosafety Level 1 species), B. cepacia can cause life-threatening pulmonary infection in persons with cystic fibrosis. (cdc.gov)
  • At least five genomovars (discrete species) constitute what has recently been designated the " B. cepacia complex" (4) . (cdc.gov)
  • Because the epidemiology of B. cepacia complex infection in humans is incompletely understood, the threat posed by the inclusion of this species in biopesticides and bioremedial products is difficult to quantify. (cdc.gov)
  • Since its assembly, however, several additional species within the B . cepacia complex have been described, and therefore we propose to update the previously described panel. (asm.org)
  • we used a polymerase chain reaction for coagulase‐nega tive staphylococci (CoNS) andBurkholderia cepacia complex (BCC) species identification. (medworm.com)
  • Most confusion surrounding this species name was initially due to its transfer from the genus Pseudomonas to the newly described genus Burkholderia by Yabuuchi et al. (cdc.gov)
  • The practice of renaming individual BBC genomovars with species names when phenotypic differentiation becomes available has heightened the confusion, as in the renaming of B. cepacia genomovar II to B. multivorans, where problems arise both with physicians (in infection control) and with patients (psychological acceptance of the disease). (cdc.gov)
  • The correct pronunciation of both the genus Burkholderia and the species cepacia is still debated. (cdc.gov)
  • Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with cystic fibrosis. (cochrane.org)
  • No studies looking at the eradication of Burkholderia cepacia complex species were identified. (cochrane.org)
  • This group of five phenotypically similar species is referred to as the B. cepacia complex. (nih.gov)
  • The data presented also demonstrate that Pseudomonas glathei and Pseudomonas pyrrocinia should be reclassified as Burkholderia species. (nih.gov)
  • B. cepacia complex species are obligate aerobic gram-negative rods that do not ferment glucose and are catalase positive. (antimicrobe.org)
  • Burkholderia cepacia ( B. cepacia ) complex is composed of 20 phylogenetically closely related bacterial species. (elsevier.es)
  • Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. (cochrane.org)
  • The Burkholderia cepacia complex (Bcc) consists of 17 closely related species of opportunistic bacterial pathogens, which are particularly problematic for cystic fibrosis patients and immunocompromised individuals. (ugent.be)
  • Burkholderia is an important bacterial genus with a complex taxonomy that contains species of both ecological and pathogenic importance, including nine closely related species collectively termed the Burkholderia cepacia complex (BCC). (asm.org)
  • Members of the Burkholderia cepacia complex (BCC) are closely related bacterial species that can act as opportunistic pathogens primarily affecting patients with cystic fibrosis (CF) ( 17 , 33 ). (asm.org)
  • The purified protein was approximately 25 kDa and is highly similar to several autoinducer proteins of the LuxI family among Burkholderia species. (peerj.com)
  • The variation in fli C sequences of B. cepacia was far greater than that with B. pseudomallei , supporting the view that ' B. cepacia ' as currently defined, may comprise several different genomic species. (microbiologyresearch.org)
  • One of the most problematic infectious agents are the microorganisms belonging to the Burkholderia cepacia complex (Bcc), a group of nine closely related bacterial species initially designated as genomovars prior to their formal naming [ 2 ]. (biomedcentral.com)
  • Left: Dynamics of log 10 -transformed species-specific cell concentrations of (A) P. aeruginosa , (C) B. cepacia , and (E) S. aureus . (biomedcentral.com)
  • Actually the B. cepacia is subdivided in nine different genomic species that show morphological similarity, called genomovars. (bvsalud.org)
  • The Burkholderia cepacia complex (Bcc) species are important opportunistic pathogens with intrinsic antibiotic resistance. (warwick.ac.uk)
  • BACKGROUND: Colonization with bacterial species from the Burkholderia cepacia complex (Bcc) is associated with fast health decline among individuals with cystic fibrosis. (inrs.ca)
  • The Burkholderia cepacia complex (Bcc) is a collection of closely related, genetically distinct, ecologically diverse species known to cause life-threatening infections in cystic fibrosis (CF) patients. (cdc.gov)
  • Bcc bacteria are now recognized as important opportunistic pathogens that can cause variable lung infections in cystic fibrosis patients, which result in asymptomatic carriage, chronic infection or 'cepacia syndrome', which is characterized by a rapid decline in lung function that can include invasive disease. (nih.gov)
  • The recall is due to risk of product contamination with B.cepacia and the potential for human infection. (cdc.gov)
  • Even a single significant nosocomial infection with B. cepacia may warrant investigation. (thefreedictionary.com)
  • The first detailed description of the clinical significance of " B. cepacia " colonization and infection was published in 1984 ( 47 ). (asm.org)
  • documented the increasing prevalence of " B. cepacia " colonization and infection in the Toronto, Canada, CF treatment center and described the so-called "cepacia syndrome," a severe progressive respiratory failure with bacteremia that occurs in about 20% of all infected CF patients. (asm.org)
  • Since " B. cepacia " is resistant to most antimicrobial agents, effective therapies are not straightforward and management efforts are therefore aimed at prevention of infection ( 35 , 63 ). (asm.org)
  • However, the efficiency of infection control measures are determined by the accuracy with which " B. cepacia " is diagnosed, and poor laboratory proficiency in identification of this organism still prevails ( 17 , 40 , 75 ). (asm.org)
  • Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function. (clinicaltrials.gov)
  • The inter-city spread of B cepacia through transfer of a colonized patient and the impact of infection control measures in containing inter-patient transmission were investigated. (nih.gov)
  • Transfer of a colonized patient from Center A to Center B was associated with an increase in B cepacia complex infection in Center B, all of which was with the Center A dominant strain. (nih.gov)
  • Burkholderia cepacia does cause significant infection not only in cystic fibrosis, chronic granulomatous disease, and immunocompromised patients, but also in healthy individuals. (bmj.com)
  • Burkholderia cepacia is an important pathogen in cystic fibrosis (CF) and an infrequent cause of nosocomial infection in non-CF patients. (umass.edu)
  • Burkholderia cepacia infection is much less common, but it is notorious for being associated with cross infection and the possibility of rapid deterioration, known as the cepacia syndrome 2 - 4 . (ersjournals.com)
  • We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent. (cochrane.org)
  • This review highlights an urgent need for more research into new ways of treating long-term Burkholderia cepacia infection in people with cystic fibrosis. (cochrane.org)
  • This review aims to examine the current treatment options for people with cystic fibrosis with acute infection with Burkholderia cepacia complex and to identify an evidence-based strategy that is both safe and effective. (cochrane.org)
  • To identify whether treatment of Burkholderia cepacia complex infections can achieve eradication, or if treatment can prevent or delay the onset of chronic infection. (cochrane.org)
  • To investigate an outbreak of Burkholderia (formerly ( Pseudomonas ) cepacia respiratory tract colonization and infection in mechanically ventilated patients. (annals.org)
  • 42 mechanically ventilated patients who developed respiratory tract colonization or infection with B. cepacia and 135 ventilator-dependent controls who were not colonized and did not develop infections. (annals.org)
  • 42 patients had B. cepacia respiratory tract colonization or infection. (annals.org)
  • The rapid increase in Pseudomonas (Burkholderia) cepacia infection in cystic fibrosis (CF) patients suggests epidemic transmission, but the degree of transmissibility remains controversial as conflicting conclusions have been drawn from studies at different CF centres. (umass.edu)
  • B. cepacia complex can survive for long periods in water or disinfectants, and healthcare-associated outbreaks of B. cepacia complex infection have been linked to contaminated nebulized and intravenous medications and solutions, including compounded and commercially distributed products, skin care products, disinfectants, and to inadequate disinfection of reusable medical devices ( 20 , 47 , 49 , 58 ). (antimicrobe.org)
  • B. cepacia complex is an important cause of chronic respiratory infection among persons with cystic fibrosis ( 40 ) and of pneumonia, septicemia, and soft tissue abscesses among persons with chronic granulomatous disease ( 52 , 59 ). (antimicrobe.org)
  • Which antibiotics are best to treat worsening symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection? (cochrane.org)
  • Infections in CF patients with Bcc bacteria generally lead to a more rapid decline in lung function, and in some cases to the 'cepacia syndrome', a virtually deadly exacerbation of the lung infection with systemic manifestations. (microbiologyresearch.org)
  • During the past decade a number of studies have helped to elucidate the epidemiology of B. cepacia infection among CF patients. (apsnet.org)
  • In contrast to considerable information on the molecular and social epidemiology of B. cepacia infection in humans, little is known about the organism's virulence determinants. (apsnet.org)
  • For microbiologists, hospital infection control officers, caregivers, and most of all the CF community, the changes in our understanding of the taxonomy, epidemiology and pathogenesis of the bacterium 'B. cepacia' are complex. (cf.ac.uk)
  • The Hong Kong Centre for Health Protection (CHP) reports investigating a cluster of invasive Burkholderia cepacia infection affecting nine persons who had a history of injecting drugs. (outbreaknewstoday.com)
  • The source of infection was most likely from hematogenous spread, as the patient's blood cultures were positive for B. cepacia. (elsevier.com)
  • Burkholderia cepacia ( B. cepacia ) is an opportunistic, Gram negative pathogen which causes infection mainly in immunocompromised population and associated with high rate of morbidity and mortality in cystic fibrosis patients. (diagrid.org)
  • Although co-trimoxazole has been generally considered the drug of choice for B. cepacia infections, ceftazidime, doxycycline, piperacillin, and meropenem are considered to be viable alternative options in cases where co-trimoxazole cannot be administered because of hypersensitivity reactions, intolerance, or resistance. (wikipedia.org)
  • The variable severity of Burkholderia cepacia complex infections in cystic fibrosis (CF) has recently been ascribed to differences in the virulence between genomovars. (hindawi.com)
  • In the early 1980s Burkholderia cepaciabecame associated with epidemics of severe lung infections ('cepacia syndrome') traced, in many cases, to CF treatment centers and social gatherings where CF patients apparently acquired the disease from other B. cepacia-infected individuals (19). (apsnet.org)
  • CDC is collaborating with the Food and Drug Administration (FDA), state and local health departments, and healthcare facilities to investigate recent outbreak of Burkholderia cepacia infections associated with exposure to liquid docusate. (cdc.gov)
  • PharmaTech liquid docusate products were also implicated in an outbreak of B. cepacia infections in 2016. (cdc.gov)
  • Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. (thefreelibrary.com)
  • In patients without cystic fibrosis, B. cepacia infections are almost all nosocomial or related to IV drug abuse. (thefreedictionary.com)
  • B cepacia may also cause urinary tract infections and infect sterile body sites. (thefreedictionary.com)
  • B. cepacia " can also cause lung infections in chronic granulomatous disease patients, and infections in these patients are associated with pneumonia and septicemia and are often lethal ( 2 , 58 , 72 , 96 ). (asm.org)
  • B. cepacia " infections in immunocompetent patients occur only sporadically, but several cases of pseudoepidemics and nosocomial infections, often caused by contaminated disinfectants and anesthetic solutions, have been reported ( 3 , 43 , 50 , 107 ). (asm.org)
  • Despite the advances that have been made in the understanding of the epidemiology, " B. cepacia " infections still have a considerable impact on morbidity and mortality in CF patients ( 18 , 61 , 62 , 63). (asm.org)
  • At present, it appears that all five B. cepacia genomovars are capable of causing infections in vulnerable persons (4) . (cdc.gov)
  • Despite the advances that have been made in the understanding of the taxonomy and epidemiology of this group, infections of the respiratory tract with B . cepacia complex organisms still have a considerable impact on morbidity and mortality in cystic fibrosis (CF) patients ( 4 , 5 , 6 ). (asm.org)
  • Randomised or quasi-randomised studies in people with cystic fibrosis of antibiotics or alternative therapeutic agents used alone or in combination, using any method of delivery and any treatment duration, to eradicate Burkholderia cepacia complex infections compared to another antibiotic, placebo or no treatment. (cochrane.org)
  • Sfeir MM . Burkholderia cepacia complex infections: more complex than the bacterium name suggest. (eurosurveillance.org)
  • An outbreak of Burkholderia cepacia complex infections associated with contaminated liquid docusate. (eurosurveillance.org)
  • A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. (eurosurveillance.org)
  • One potential virulence factor implicated in the pathogenesis of B. cepacia infections is the production of siderophores. (asm.org)
  • Burkholderia cepacia complex infections present a significant challenge for people with cystic fibrosis and their clinicians. (cochrane.org)
  • Although evidence-based guidelines exist for treating respiratory exacerbations involving Pseudomonas aeruginosa, these cannot be extended to Burkholderia cepacia complex infections. (cochrane.org)
  • Most troublesome is the fact that lung infections with BCC can culminate in a rapidly fatal condition in which patients develop a progressive, necrotizing pneumonia and sepsis commonly referred to as "cepacia syndrome" ( 23 ). (asm.org)
  • Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence. (microbiologyresearch.org)
  • Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. (semanticscholar.org)
  • While Burkholderia cepacia complex (Bcc) is one of the least prevalent bacteria causing infections among CF patients, it is one of the most dangerous. (informa.com)
  • Burkholderia cepacia has been described as a cause of opportunist infections in patients with immune deficiency because of the high transmission rates. (bvsalud.org)
  • Our report not only describes the case but also reviews the difficulty in treating B. cepacia infections. (elsevier.com)
  • Dizbay M, Tunccan OG, Sezer B E, Aktas F, Arman D (2009) Nosocomial Burkholderia cepacia infections in a Turkish university hospital: a five-year surveillance. (ejobios.org)
  • B. cepacia complex bacteria as phytopathogens. (apsnet.org)
  • B. cepacia complex bacteria as biocontrol agents. (apsnet.org)
  • B. cepacia complex bacteria are naturally abundant in soil, water, and on plant surfaces (4). (apsnet.org)
  • B. cepacia complex bacteria as human pathogens. (apsnet.org)
  • B. cepacia complex bacteria can grow in aqueous environments, can exhibit resistance to preservatives, and can cause contamination of liquid medications or other liquid products. (cdc.gov)
  • B. cepacia complex bacteria and organisms that may be confused with them will be altogether referred to as B. cepacia -like organisms. (asm.org)
  • Seventeen (81%) of 21 Center A patients from whom B cepacia complex bacteria were recovered between 1981 and 1987 and 40 (97%) of 41 patients culture-positive between 1996 and 2000 were infected with the same genomovar III strain. (nih.gov)
  • Multiple sequence alignment & phylogram with closely related sequence accessions using MEGA Software revealed this naturally occurring biocontrol bacteria belongs to Burkholderia cepacia complex genomovar I based on the Biolog identification system with 16S rDNA gene sequence analysis. (scirp.org)
  • One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. (cochrane.org)
  • We did not find any trials which compared groups of volunteers with exacerbations who were also infected with Burkholderia cepacia complex bacteria, who were given different treatments at random. (cochrane.org)
  • More research is needed to find out which treatments are best for improving lung function and survival and for reducing side effects and length of time spent in hospital for people infected with Burkholderia cepacia complex bacteria experiencing an exacerbation. (cochrane.org)
  • Burkholderia cepacia complex bacteria are resistant to many common antibiotics and able to acquire resistance against many more. (cochrane.org)
  • If you are a researcher working with B. cepacia complex bacteria and are interested in contributing to this site, please register and become a member. (ibcwg.org)
  • First discovered in 1949 B.cepacia was discovered by Walter Burkholder in and is the bacteria that cause the common onion skin to rot. (antibioticresearch.org.uk)
  • The agency confirmed the product had been contaminated with Burkholderia cepacia , a bacteria linked to an outbreak in five states. (cdc.gov)
  • Our obsession with bacteria from the Burkholderia cepacia complex started in the early 1990s. (cf.ac.uk)
  • Burkholderia cepacia is a bacteria which are commonly found in water, soil, and moist environments. (outbreaknewstoday.com)
  • INTRODUÇÃO: Em contraste aos bons resultados do transplante pulmonar no tratamento de pacientes com doença supurativa pulmonar avançada, a colonização por Burkholderia cepacia complex (BCC), sobretudo o genomovar III, vem sendo relacionada a pior prognóstico e, por conseguinte, uma contraindicação ao procedimento em alguns centros transplantadores. (usp.br)
  • INTRODUCTION: Notwithstanding the good results of lung transplantation for treatment of patients with advanced lung suppurative disease, colonization by Burkholderia cepacia complex (BCC), especially genomovar III has been related to a worse prognosis in these patients and therefore contraindication to the procedure certain centers. (usp.br)
  • CP000869 Burkholderia multivorans ATCC 17616 chromosome 2, complete sequence. (atcc.org)
  • Burkholderia multivorans in 1999. (ersjournals.com)
  • Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. (nih.gov)
  • Pseudomonas cepacia colonization of the lung is associated with increased morbidity and mortality for cystic fibrosis (CF) patients. (nih.gov)
  • Our data support the potential role of PCR technology in the rapid, sensitive, and definitive detection of P. cepacia in CF sputum samples, even in the context of concomitant P. aeruginosa colonization. (nih.gov)
  • Pulmonary colonization of B. cepacia can cause accelerated decline in lung funtions and cause "cepacia syndrome," which is a progressive pneumonic illness that is fatal and essentially untreatable [4] . (kenyon.edu)
  • Clustering of new cases in some centers and the decrease of colonization of new patients following segregation of colonized and noncolonized patients in other centers suggested that " B. cepacia " could be transmitted between CF patients. (asm.org)
  • A recent study of CF patients over a 20-year period concluded that colonization with B. cepacia significantly increased the risk of mortality at all levels of pulmonary function and that the risk was significantly higher for children ( 6 ). (asm.org)
  • Descriptions of clinical outcomes of respiratory tract colonization, including 'cepacia syndrome', a condition characterized by severe necrotizing pneumonia and sepsis, soon followed. (apsnet.org)
  • 3. Thomassen MJ, Demko CA, Klinger JD, Stern RC (1985) Pseudomonas cepacia colonization among patients with cystic fibrosis. (diagrid.org)
  • Several distinct genomovars are collectively referred to as B. cepacia complex (Bcc) 7 . (ersjournals.com)
  • However, uncertainty still surrounds the clinical relevance of its evolving taxonomy, particularly in regards to the nine described genomovars of the B. cepacia complex (BCC). (cdc.gov)
  • the remaining B. cepacia groups are referred to as genomovars I, III, and IV, pending additional differential phenotypic tests. (nih.gov)
  • In the 1980s, outbreaks of B. cepacia in individuals with CF were associated with a 35% death rate. (wikipedia.org)
  • This has led to healthcare-associated outbreaks of B. cepacia complex. (cdc.gov)
  • In the past 2 decades, Burkholderia cepacia has emerged as a human pathogen causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. (cdc.gov)
  • Background: Burkholderia cepacia complex (Bcc) has caused healthcare-associated outbreaks, often in association with contaminated products. (cdc.gov)
  • Burkholderia cepacia complex outbreaks are associated with poor outcomes and sustained mortality rates. (lww.com)
  • An update will be posted at https://www.cdc.gov/hai/outbreaks/b-cepacia/index.html in approximately one week. (cdc.gov)
  • We report 2 consecutive outbreaks of the Burkholderia cepacia complex (Bcc) in an intensive care unit (ICU) and describe its characteristics and consequences. (cdc.gov)
  • While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity. (asm.org)
  • Bernier SP, Silo-Suh L, Woods DE, Ohman DE, Sokol PA (2003) Comparative analysis of plant and animal models for characterization of Burkholderia cepacia virulence. (springer.com)
  • Burkholderia cepacia complex: virulence characteristics, importance and relationship with cystic fibrosis. (bvsalud.org)
  • For example, although the genetic elements responsible for TCE degradation by B. cepacia have been cloned, their recombination into another nonpathogenic bacterial host (e.g. (cdc.gov)
  • Burkholderia cepacia , an important gram-negative bacterial pathogen in patients with cystic fibrosis, may cause premature death in these patients. (cdc.gov)
  • Originally described by Burkholder as a causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion). (unboundmedicine.com)
  • A bacterial disease of onions tentatively called bacterial canker appears to be caused primarily by B. cepacia. (apsnet.org)
  • The objective of this review is to describe Burkholderia cepacia as a bacterial complex with high pathogenicity and variability of habitats. (bvsalud.org)
  • It was first isolated in patients with cystic fibrosis (CF) in 1977, when it was known as Pseudomonas cepacia. (wikipedia.org)
  • Formerly known as Pseudomonas cepacia, the bacterium now known as Burkholderia cepacia, was first described in 1950 as the cause of sour skin of onions by Cornell University plant pathologist Walter Burkholder (1). (apsnet.org)
  • Formerly known as Pseudomonas cepacia. (thefreedictionary.com)
  • Burkholderia cepacia (previously known as Pseudomonas cepacia ) is a Gram negative, oxidase positive, non-fermentative bacilli. (bmj.com)
  • Burkholderia cepacia lipase (BCL) formerly known as Pseudomonas cepacia lipase has been shown to be a useful enzyme which catalyzes a broad range of different reactions in water and non-polar solvents under mild conditions. (biomedcentral.com)
  • Burkholderia cepacia is a catalase-producing, non-lactose-fermenting, aerobic Gram-negative bacterium found in various aquatic environments. (thefreedictionary.com)
  • Burkholderia cepacia is a remarkably versatile bacterium. (apsnet.org)
  • The interaction between the endophytic bacterium, B. cepacia and F. oxysporum f. sp. (ukzn.ac.za)
  • TEM observation showed that in the banana plant B. cepacia was closely associated with the healthy banana roots and a matrix was frequently found to be present between the bacterium and the plant surface. (ukzn.ac.za)
  • Burkholderia cepacia (Palleroni and Holmes) Yabuuchi et al. (atcc.org)
  • and the "cepacia" syndrome with persistently positive blood cultures and death. (antimicrobe.org)
  • The optimum antibiotic treatment for 'cepacia syndrome' remains unclear and mortality unfortunately remains very high. (cysticfibrosis.online)
  • Today, B. cepacia complex is a very important problem for the acquired immunodeficiency syndrome and cystic fibrosis patients. (bvsalud.org)
  • For example, it was shown that the B. cepacia type strain ATCC 25416T (isolated from rotting onions in the 1940s) was also isolated from sputum of a CF patient in the UK (32). (apsnet.org)
  • Pyrimidine synthesis in Burkholderia cepacia ATCC 25416. (atcc.org)
  • B. cepacia is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease (such as cystic fibrosis or chronic granulomatous disease). (wikipedia.org)
  • B. cepacia has emerged as a human respiratory opportunistic pathogen in individuals with weakened immune systems or chronic lung disease, espeically cystic fibrosis (CS) patients, within the past 30 years and has therefore recieved increased attention from the scientific community. (kenyon.edu)
  • We describe a case of an otherwise healthy, community-dwelling man who presented with subacute cavitary lung disease, the causative organism of which turned out to be Burkholderia cepacia complex. (medworm.com)
  • One of these bugs, Burkholderia cepacia , causes a lot of problems for people with cystic fibrosis because it is very difficult to treat and makes their lung disease deteriorate faster than it otherwise would. (cochrane.org)
  • There remain no objective guidelines for strategies to eradicate Burkholderia cepacia complex in cystic fibrosis lung disease, as these are inherently resistant to the majority of antibiotics and there has been very little research in this area. (cochrane.org)
  • Colonisation with B cepacia and P aeruginosa in children is associated with a more rapid decline in lung function and a significantly increased mortality compared with cases colonised with P aeruginosa alone. (bmj.com)
  • B. cepacia complex emerged in the late 1970s as a cystic fibrosis respiratory pathogen, associated with accelerated decline in pulmonary functions and reduced survival, especially among those with more advanced lung disease or who had undergone lung transplantation ( 16 , 19 , 34 ). (antimicrobe.org)
  • 4. De Soyza A, Corris PA (2003) Lung transplantation and the Burkholderia cepacia complex. (diagrid.org)
  • The organism is usually cultured in Burkholderia cepacia agar (BC agar), which contains crystal violet and bile salts to inhibit the growth of Gram-positive cocci, and ticarcillin and polymyxin B to inhibit the growth of other Gram-negative bacilli. (wikipedia.org)
  • Historically regarded as an organism of low pathogenicity, B. cepacia complex can be transmitted person to person in both healthcare and non-healthcare settings, and both direct and indirect contact with infectious secretions and droplet spread have been implicated in transmission ( 25 , 31 , 32 , 39 , 63 ). (antimicrobe.org)
  • We describe the first reported case of a spontaneous septic arthritis caused by Burkholderia cepacia, the organism responsible for onion skin rot. (elsevier.com)
  • Burkholderia (formerly Pseudomonas ) cepacia is an opportunistic pathogen in immunocompromised patients, particularly those with cystic fibrosis (CF) or chronic granulomatous disease (reviewed in references 8 and 9 ). (asm.org)
  • Matthaiou DK , Chasou E , Atmatzidis S , Tsolkas P . A case of bacteremia due to Burkholderia cepacia in a patient without cystic fibrosis. (microbiologyresearch.org)
  • Characteristics of patients with Burkholderia cepacia bacteremia. (microbiologyresearch.org)
  • Despite post-operative resolution of this immunocompromised patient's shoulder symptoms, he was unable to survive the B. cepacia bacteremia. (elsevier.com)
  • Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. (asm.org)
  • By virtue of its ability to antagonize a number of soilborne plant pathogens, B. cepacia is an attractive natural alternative to currently used chemical pesticides, such as captan, mancozeb, and metalaxyl. (cdc.gov)
  • Members of the genus Burkholderia are known for their ability to suppress soil-borne fungal pathogens by the production of various antibiotic compounds. (uzh.ch)
  • In addition, B. cepacia was able to inhibit several fungal pathogens in vitro. (ukzn.ac.za)
  • Susceptible persons can acquire B. cepacia organisms through person-to-person contact, contact with contaminated surfaces, and exposure to it in the enviroment (i.e. soil and water) [6] . (kenyon.edu)
  • Caraher E, Reynolds G, Murphy P, McClean S, Callaghan M (2007) Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro. (springer.com)
  • Of these, BCSA agar is the most useful in supporting the growth of B. cepacia complex and suppressing the growth of other organisms. (antimicrobe.org)
  • Multicentre randomised clinical trials are needed to assess the effectiveness of different antibiotic regimens in people with cystic fibrosis infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation and chronically infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • Randomised and quasi-randomised controlled trials of treatments for exacerbations of pulmonary symptoms in people with cystic fibrosis chronically infected with organisms of the Burkholderia cepacia complex. (cochrane.org)
  • Healthcare facilities should consider implementing contact precautions in the setting of an ongoing outbreak of B. cepacia to reduce the risk of transmission. (cdc.gov)
  • Outbreak of Burkholderia cepacia pseudobacteraemia caused by intrinsically contaminated commercial 0.5% chlorhexidine solution in neonatal intensive care units. (eurosurveillance.org)
  • An outbreak of Burkholderia cepacia complex associated with intrinsically contaminated nasal spray. (eurosurveillance.org)
  • Three-year outbreak of pseudobacteremia with Burkholderia cepacia traced to a contaminated blood gas analyzer. (eurosurveillance.org)
  • Outcome of Burkholderia (Pseudomonas) cepacia colonisation in children with cystic fibrosis following a hospital outbreak. (bmj.com)
  • Furthermore, the possibility of B. cepacia colonisation induces a high level of anxiety in the CF population. (ersjournals.com)
  • BACKGROUND--While there are reports on the outcome in adults and teenagers with cystic fibrosis of colonisation with Burkholderia (Pseudomonas) cepacia, there is little information in children. (bmj.com)
  • The lack of a sensitive detection method for Pseudomonas cepacia in CF sputum has resulted in controversy regarding its epidemiology. (nih.gov)
  • When sputum samples from three CF patients chronically colonized with P. cepacia and P. aeruginosa were analyzed, P. cepacia was detected in all three specimens by PCR, but only in two when selective culture was performed. (nih.gov)
  • Optimal isolation of B. cepacia from CF sputum requires the use of selective culture media 6 . (ersjournals.com)
  • Recovery of Burkholderia cepacia from sputum culture from persons with cystic fibrosis (CF) was initially reported in the late1970s. (apsnet.org)
  • We sought to determine whether the same Burkholderia cepacia complex strain has persisted as the dominant clonal lineage among patients in a large cystic fibrosis (CF) treatment center during the past 2 decades. (nih.gov)
  • This strain, designated PHDC, lacks both B cepacia epidemic strain and cblA markers. (nih.gov)
  • A review of the literature reveals that this panel has been used extensively in various areas of research (for a complete list of publications using this panel, see http://go.to/cepacia and follow the link to B . cepacia experimental strain panel). (asm.org)
  • In this work, the genome of B. cepacia strain GG4, a plasmid-free strain capable of AHL synthesis was explored. (peerj.com)
  • Our data show, for the first time, the cloning and characterization of the LuxI homologue from B. cepacia strain GG4 and confirmation of its AHL synthesis activity. (peerj.com)
  • Study findings suggest that biofield treatment has a significant effect on the phenotypic character and biotype number of multidrug resistant strain of B. cepacia . (diagrid.org)
  • Optimization of olive oil hydrolysis process using immobilized Lipase from Burkholderia cepacia sp. (thefreedictionary.com)
  • in Polyurethane/Otimizacao do processo de hidrolise do azeite de oliva utilizando lipase Burkholderia cepacia sp. (thefreedictionary.com)
  • O objetivo deste trabalho foi avaliar o efeito do uso de líquido iônico prótico - LIP (pentanoato de N-metilmonoetalonamina - C5) na lipase de Burkholderia cepacia(LBC) imobilizada por encapsulação em sílica aerogel modificado. (blucher.com.br)
  • Industrial enzymes lipase PS (LPS) and lipase AK (LAK), which originate from Burkholderia cepacia and Pseudomonas fluorescens, respectively, are synthetically useful biocatalysts. (elsevier.com)
  • Therefore, molecular dynamics simulations of a closed homology model and an open crystal structure of Burkholderia cepacia lipase in water and toluene were performed to investigate the influence of solvents on structure, dynamics, and the conformational transition of the lid. (biomedcentral.com)
  • The conformational transition of B. cepacia lipase was dependent on the solvent. (biomedcentral.com)
  • In simulations of closed B. cepacia lipase in water no conformational transition was observed, while in three independent simulations of the closed lipase in toluene the lid gradually opened during the first 10-15 ns. (biomedcentral.com)
  • Conformational transitions between the experimentally observed closed and open conformation of the lid were observed by multiple molecular dynamics simulations of B. cepacia lipase. (biomedcentral.com)
  • While no experimental structure of BCL in the closed conformation is available, a homologous lipase from Burkholderia glumae (BGL) [PDB: 1QGE] [ 17 ] with a sequence identity of 84% has been crystallized in the closed conformation. (biomedcentral.com)
  • Abbas FA (2017) Antibiotic Susceptibility Patterns of Burkholderia cepacia Isolated from Different Clinical Specimens. (ejobios.org)
  • In May 2017, the FDA advised on Contamination Risk for Burkholderia cepacia concerning water-based drug products to remind drug manufacturers of non-sterile products to establish suitable methods to prevent objectionable microorganisms contamination. (smi-online.co.uk)
  • The outcome for children who became colonised with B cepacia was compared with that in 33 children who continued to be colonised with Pseudomonas aeruginosa alone. (bmj.com)
  • RESULTS--Children colonised with B cepacia were older and more poorly nourished than those colonised with P aeruginosa, but did not have poorer pulmonary function. (bmj.com)
  • Development of a PCR probe test for identifying Pseudomonas aeruginosa and Pseudomonas (Burkholderia) cepacia. (bmj.com)
  • Right: Dynamics of relative frequencies of (B) viable and dead cells of P. aeruginosa , (D) viable and dead cells of B. cepacia and (F) viable, damaged and dead cells of S. aureus . (biomedcentral.com)
  • There does not appear to be a greater inflammatory response to B. cepacia complex than to P. aeruginosa (Hendry et al, 1999). (cysticfibrosis.online)
  • Burkholderia cepacia has emerged as an important pathogen in patients with cystic fibrosis. (asm.org)
  • The B. cepacia complex is a recognised respiratory pathogen in patients with cystic fibrosis. (elsevier.es)
  • Three German patients developed nosocomial pneumonia after cardiac surgery and had Burkholderia cepacia complex detected in respiratory specimens. (eurosurveillance.org)
  • Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. (elsevier.com)
  • Because of these factors, management of B. cepacia complex patients is difficult [4] . (kenyon.edu)
  • Reports of B. cepacia in CF patients appeared in the late 1970s and early 1980s. (kenyon.edu)
  • An epidemic of burkholderia cepacia transmitted between patients with and without cystic fibrosis. (umass.edu)
  • four B. cepacia patients died and none of the control patients died. (ersjournals.com)
  • Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. (elsevier.com)
  • B. cepacia should be considered a potential pathogen in hospitalized patients with severe underlying diseases, particularly those with indwelling central venous catheters. (elsevier.com)
  • 7. Aaron SD, Ferris W, Henry DA, Speert DP, Macdonald NE (2000) Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia. (diagrid.org)
  • Potential of metabolomics to reveal Burkholderia cepacia complex pathogenesis and antibiotic resistance. (cdc.gov)
  • Even though in B. cepacia , taxonomic issues rather than pronunciation are at the root of confusion, the pathogen neatly encapsulates several aspects of the linguistic conundrum involving "correct" pronunciation of Latin binomials. (cdc.gov)
  • According to the U.S. Cystic Fibrosis Foundation's 2012 National Patient Registry, 2.6 percent of all persons with cystic fibrosis were infected with B. cepacia complex compared to 3.1% in 2005 ( 1 ). (antimicrobe.org)
  • Burkholderia genus in 1992 on the basis of phenotypic characteristics, 16S rRNA sequences, DNA-DNA homology values, and cellular lipid and fatty acid composition [2] . (kenyon.edu)
  • The debate is mainly about the correct pronunciation of cepacia , but the genus name, Burkholderia , also deserves some consideration. (cdc.gov)
  • Social interactions in the Burkholderia cepacia complex: biofilms and quorum sensing. (semanticscholar.org)
  • Quorum Sensing Influences Burkholderia thailandensis Biofilm Development and Matrix Production. (semanticscholar.org)
  • article{Coenye2010SocialII, title={Social interactions in the Burkholderia cepacia complex: biofilms and quorum sensing. (semanticscholar.org)
  • CONCLUSIONS--This study provides further evidence for person-to-person spread of B cepacia and confirms the effectiveness of simple isolation measures in interrupting spread. (bmj.com)
  • Other glucose nonfermenters, like Stenotrophomonas maltophilia , Alcaligenes xylosoxidans , R. pickettii , and Burkholderia gladioli , can frequently be found as well, but their role in the decline of pulmonary function is unclear ( 14 , 19 , 30 ). (asm.org)
  • Pulmonary exacerbations due to B. cepacia are associated with damaging inflammation and, in vitro, the bacterium's lipopolysaccharide and lipopeptide haemolysin stimulate a potentially damaging cytokine and neutrophil response. (apsnet.org)
  • 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540069/all/Burkholderia_cepacia_complex. (unboundmedicine.com)
  • Corkill JE, Deveney J, Pratt J, Shears P, Smyth A, Heaf D, Hart CA (1994) Effect of pH and CO2 on in vitro susceptibility of Pseudomonas cepacia to beta-lactams. (ejobios.org)
  • Click here to see other related B. cepacia biocontrol articles from APS Journals. (apsnet.org)
  • Burns JL, Jonas M, Chi EY, Clark DK, Berger A, Griffith A (1996) Invasion of respiratory epithelial cells by Burkholderia ( Pseudomonas ) cepacia . (springer.com)
  • Burkholderia cepacia is known to invade and survive within respiratory epithelial cells. (brad.ac.uk)
  • Burkholderia cepacia is an aerobic, Gram-negative bacillus, which exhibits innate resistance to multiple antibiotics and disinfectants. (microbiologyresearch.org)