Burkholderia cenocepacia: A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.Burkholderia: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.Burkholderia cepacia complex: A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.Burkholderia Infections: Infections with bacteria of the genus BURKHOLDERIA.Burkholderia cepacia: A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.Burkholderia pseudomallei: A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.Quorum Sensing: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Onions: Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.Melioidosis: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.Acyl-Butyrolactones: Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Biofilms: Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.Sulfamerazine: A sulfanilamide that is used as an antibacterial agent.Rhizoctonia: A mitosporic Ceratobasidiaceae fungal genus that is an important plant pathogen affecting potatoes and other plants. There are numerous teleomorphs.Bacterial Proteins: Proteins found in any species of bacterium.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Microbial Viability: Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.Mutagenesis, Insertional: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.Burkholderia gladioli: A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.Bronchopneumonia: Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.Genes, Bacterial: The functional hereditary units of BACTERIA.Polymyxin B: A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.Glanders: A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.Fatty Acids, Monounsaturated: Fatty acids which are unsaturated in only one position.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Virulence Factors: Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Phagosomes: Membrane-bound cytoplasmic vesicles formed by invagination of phagocytized material. They fuse with lysosomes to form phagolysosomes in which the hydrolytic enzymes of the lysosome digest the phagocytized material.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Microscopy, Electron, Transmission: Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.Sputum: Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Glycolysis: A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.Gluconeogenesis: Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.Methanosarcina: A genus of anaerobic, irregular spheroid-shaped METHANOSARCINALES whose organisms are nonmotile. Endospores are not formed. These archaea derive energy via formation of methane from acetate, methanol, mono-, di-, and trimethylamine, and possibly, carbon monoxide. Organisms are isolated from freshwater and marine environments.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.Bacterial Secretion Systems: In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Phenylacetates: Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.Penicillium chrysogenum: A mitosporic fungal species used in the production of penicillin.Homogentisic Acid

BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB. (1/74)

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Ecological succession in long-term experimentally evolved biofilms produces synergistic communities. (2/74)

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Inactivation of macrophage Rab7 by Burkholderia cenocepacia. (3/74)

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The pobA gene of Burkholderia cenocepacia encodes a group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin. (4/74)

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The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes. (5/74)

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Virulence of an emerging respiratory pathogen, genus Pandoraea, in vivo and its interactions with lung epithelial cells. (6/74)

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Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. (7/74)

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CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. (8/74)

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*Burkholderia cenocepacia

"Burkholderia cenocepacia". NCBI Taxonomy Browser. 95486. Type strain of Burkholderia cenocepacia at BacDive - the Bacterial ... is Burkholderia cenocepacia, a member of a bacterial group collectively referred to as the Burkholderia cepacia complex (Bcc ... Burkholderia cenocepacia is a species of Gram-negative bacteria that is common in the environment, can form a biofilm with ... Burkholderia cenocepacia is a Gram-negative bacterium with the ability to form a biofilm Nida H. Alshraiedeh; Sarah ...

*Burkholderia cepacia complex

Research Pathema-Burkholderia Resource Loutet SA, Valvano MA (October 2010). "A decade of Burkholderia cenocepacia virulence ... May 2007). "A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability". J. ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ... "Burkholderia cepacia complex". NCBI Taxonomy Browser. 87882. Type strain of Burkholderia cepacia complex at BacDive - the ...

*Pathogenic bacteria

Examples of these opportunistic pathogens include Pseudomonas aeruginosa, Burkholderia cenocepacia, and Mycobacterium avium. ...

*Innate immune system

... biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic ...

*H2cR sRNA

"The Novel Cis-Encoded Small RNA h2cR Is a Negative Regulator of hfq2 in Burkholderia cenocepacia". PLoS ONE. 7 (10): e47896. ... In molecular biology, the h2cR sRNA is a small RNA produced by species of the bacterial genus Burkholderia. It binds to the ...

*Immune system

Such biofilms are present in many successful infections, e.g., the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia ...

*Bacteria

Finally, some species, such as Pseudomonas aeruginosa, Burkholderia cenocepacia, and Mycobacterium avium, are opportunistic ...

*Burkholderia

... ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia cepacia Burkholderia ... glathei Burkholderia glumae Burkholderia grimmiae Burkholderia humi Burkholderia lata Burkholderia latens Burkholderia mallei ... Burkholderia cocovenenans Burkholderia contaminans Burkholderia diffusa Burkholderia dolosa Burkholderia gladioli Burkholderia ... Burkholderia stabilis Burkholderia stagnalis Burkholderia telluris Burkholderia terrestris Burkholderia territorii Burkholderia ...
Burkholderia cenocepacia ATCC ® BAA-245D-5™ Designation: Genomic DNA from Burkholderia cenocepacia strain LMG 16656 TypeStrain=False Application:
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in cystic fibrosis and other immunocompromised patients. The bacterium survives within macrophages by interfering with typical endocytic trafficking, resulting in delayed maturation of a B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia alters gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation. Furthermore, we hypothesize that specialized bacterial secretion systems are involved in the interactions between intracellular bacteria and macrophages. In this work, we characterize later-stage infection of macrophages by B. cenocepacia, showing replication within an acidified endosomal compartment suggestive of a phagolysosome. We examine differential gene expression by intracellular B. cenocepacia using selective capture of transcribed sequences (SCOTS) with both competitive enrichment and microarray analysis. We identified 766
Please Note: Ortholuge cannot be used for certain RBB analyses involving closely-related strains (e.g. Burkholderia cenocepacia J2315 versus Burkholderia cenocepacia AU 1054) because the phylogenetic distance between each ingroup protein is very small in relation to the phylogenetic distance between each ingroup protein and the associated outgroup protein. In these cases, the "Ortholuge Classification" value will be left blank which indicates Ortholuge analysis was not peformed, however the two proteins may very well be orthologs. In other cases, only some rows will be missing Ortholuge classifications, which can occur when a suitable gene could not be found in the outgroup species ...
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Scientists may have found a way to kill Burkholderia cenocepacia, a multi-drug resistant plant pathogen that causes severe infections in people with cystic fibrosis.. The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics. Researchers hope to discover novel molecules as antibiotic candidates which could disrupt the synthesis of Ara4N.. ...
4B6Z: High-Resolution Structure of the M14-Type Cytosolic Carboxypeptidase from Burkholderia Cenocepacia Refined Exploiting Pdb_Redo Strategies.
Zaradi pogoste uporabe betalaktamskih zdravil so nekatere bakterije razvile odpornost proti njim. Nekatere bakterije proizvajajo prej omejeni encim betalaktamazo, ki izniči učinek betalaktamskega antibiotika, ker cepi betalaktamski obroč.. Za preprečitev tovrstne odpornosti bakterij so na trgu kombinacije betalaktamskih antibiotikov z zaviralci betalaktamaze. Takšna kombinacija je npr. amoksicilin + klavulanska kislina. Klavulanska kislina je zaviralec betalaktamaze, ker se nepovratno veže na encim in slednji se več ne more vezati na betalaktamsko učinkovino (v tem primeru amoksicilin).. ...
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The phenylacetic acid (PA) degradative pathway is the central pathway by which complex aromatic compounds (e.g. styrene) get degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA, which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made a link in Burkholderia cenocepacia between phenylacetic acid (PA) degradation and virulence by showing that insertional mutagenesis of paaA and paaE results in PA-conditional growth and an attenuated killing phenotype in the Caenorhabditis elegans model of infection. Insertional mutagenesis of paaK1, which encodes a phenylacetyl-CoA ligase, did not result in a PA-conditional growth probably due to the presence of a second similar gene (paaK2) encoding another phenylacetyl-CoA ligase (PaaK2). Recently published crystallographic and enzyme kinetics studies comparing the two ligases show that PaaK1 is better able to bind hydroxylated PA derived molecules such as 3-hydroxyphenylacetic (3-OHPA) acid and
Essential gene studies often reveal novel essential functions for genes with dispensable homologues in other species. This is the case with the widespread family of electron transfer flavoproteins (ETFs), which are required for the metabolism of specific substrates or for symbiotic nitrogen fixation in some bacteria. Despite these non-essential functions high-throughput screens have identified ETFs as putatively essential in several species. In this study, we constructed a conditional expression mutant of one of the ETFs in Burkholderia cenocepacia, and demonstrated that its expression is essential for growth on both complex media and a variety of single-carbon sources. We further demonstrated that the two subunits EtfA and EtfB interact with each other, and that cells depleted of ETF are non-viable and lack redox potential. These cells also transition from the short rods characteristic of Burkholderia cenocepacia to small spheres independently of MreB. The putative membrane partner ETF dehydrogenase
SWISS-MODEL Repository entry for A0K321 (GCSP_BURCH), Glycine dehydrogenase (decarboxylating). Burkholderia cenocepacia (strain HI2424)
Acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a triazole group were synthesized and evaluated for their effect on quorum sensing (QS) and biofilm formation in Burkholderia cenocepacia and Pseudomonas aeruginosa. In addition, the influence of the length of the acyl-mimicking chain was investigated. The compounds showed selectivity between two different AHL QS systems. 3-(1H-1,2,3-Triazol-1-yl)dihydrofuran-2(3H)-ones, in which the 4-substituent best resembled the acyl chain of the native AHL molecule exhibited significant QS agonistic and antagonistic activities. Replacing this aliphatic substituent by a phenyl-containing moiety resulted in active inhibitors of QS. The most active compounds showed biofilm inhibitory as well as biofilm eradicating activities in both test organisms. ...
DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays. It is well documented that 25mer probes directed against different regions of the same gene produce variable signal intensity values. However, the extent to which this is true for probes of greater length (60mers) is not well characterized. Moreover, this information has not previously been reported for whole-genome arrays designed against bacteria, whose genomes may differ substantially in characteristics directly affecting microarray performance. We report here an analysis of alternative 60mer probe designs for an in-situ synthesized oligonucleotide array for the GC rich, β-proteobacterium Burkholderia cenocepacia. Probes were designed using the ArrayOligoSel3.5 software package and whole-genome microarrays synthesized by Agilent, Inc. using their in-situ, ink-jet technology platform. We first validated the quality of the microarrays as demonstrated by an average
Survival curves for D. melanogaster infected with B. cenocepacia strains.Pricking assays were performed with a minimum of 30 flies for each strain. Statistical
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CEPI is an alliance to finance and coordinate the development of new vaccines to prevent and contain infectious disease epidemics.
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Aabed, Tariq Ahmad (2018) Radiation Effects on Mesenchymal Stem Cells in a Model of Fibrosarcoma. PhD thesis, University of Sheffield. Albaz, Alrayan (2018) Investigation into Cytosine Epigenetic State in Bladder Cancer. PhD thesis, University of Sheffield. Aljadani, Saeedah (2018) Regulation of iron acquisition by an iron starvation sigma factor system in Burkholderia cenocepacia. PhD thesis, University of Sheffield. Alkathiri, Afnan (2018) Investigation the Role of ATM in Sarcomas. PhD thesis, University of Sheffield. Allocca, Gloria (2018) Defining the perivascular niche in the early stages of breast cancer bone metastasis. PhD thesis, University of Sheffield. Almaghrabi, Sarah (2018) Gene Therapy for an Experimental Autoimmune Polyglandular Syndrome 1 Model Caused by Mutations in Aire. PhD thesis, University of Sheffield. Alrahimi, Jehan (2018) The Role of Tetraspanins in Pseudomonas aeruginosa Adherence to Human Cells. PhD thesis, University of Sheffield. Alshamrani, Khalaf (2018) ...
This pipeline reflects, to the best of our knowledge, publicly available information on the status of vaccine candidates with a direction towards human use for Lassa and Nipah (as at August 2017) and for MERS-CoV (as at July 2017). Please contact [email protected] if you have evidence to report on updates to this.. ...
Chronic pulmonary infections are the principal cause of morbidity and mortality in individuals with cystic fibrosis (CF). Due to the polymicrobial nature of these infections, the identification of the particular bacterial species responsible is an essential step in diagnosis and treatment. Current diagnostic procedures are time-consuming, and can also be expensive, invasive and unpleasant in the absence of spontaneously expectorated sputum. The development of a rapid, non-invasive methodology capable of diagnosing and monitoring early bacterial infection is desired. Future visions of real-time, in situ diagnosis via exhaled breath testing rely on the differentiation of bacteria based on their volatile metabolites. The objective of this proof-of-concept study was to investigate whether a range of CF-associated bacterial species (i.e. Pseudomonas aeruginosa, Burkholderia cenocepacia, Haemophilus influenzae, Stenotrophomonas maltophilia, Streptococcus pneumoniae and Streptococcus milleri) could be ...
Ah, yes! Im dealing with Burkholderia. 16s rDNA analyses showed similarity to B. cepacia and B. cenocepacia. Perhaps the fact that B. cepacia exists as a complex of many strains (genomovars) that makes biochemical identification inaccurate; what more when I did it the conventional way. Hoping this time that the commercial kit like API could back the 16s analyses up.. ...
Blog on BCAS2 recombinant protein product: The BCAS2 bcas2 (Catalog #MBS203900) is a Recombinant Protein and is intended for research purposes only....
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Bacteria of the Burkholderia cepacia complex (Bcc) are pathogens of humans, plants, and animals. Burkholderia cenocepacia is one of the most common Bcc species infecting cystic fibrosis (CF) patients and its carriage is associated with poor prognosis. In this study, we characterized a general O-link …
A plate assay to detect bacterial lipase (EC 3.1.1.3) in a medium containing trioleoylglycerol and the fluorescent dye rhodamine B is presented. Substrate hydrolysis causes the formation of orange fluorescent halos around bacterial colonies visible upon UV irradiation. The logarithm of lipase activity from cell-free culture supernatants is linearly correlated with the diameter of halos, thereby allowing quantitation of lipase activities ranging from 1 to 30 nkat. ...
Reagents, Tools and Custom Services for molecular biology, specializing in the fields of Nano-Antibody development (nAb), Cellular Reprogramming (iPSC), Genome Editing, Fluorescent Proteins, RNAi, Viral Packaging and Protein expression.
CEPI: Part of the Problem or the Solution?. Certainly, dont tell a New World Order organization called the Coalition for Epidemic Preparedness Innovations (CEPI) about this coronavirus cure. CEPI is handing out research grants to develop a vaccine. This is free money to pharmaceutical and biotech companies and actually the whole reason for the conjured-up epidemic, to develop a vaccine with public money.. CEPI is a private/public coalition headquartered in Norway with $760-billion of funding by various countries, including the Wellcome Trust and the Bill & Melinda Gates Foundation.. Note: Burroughs Wellcome & Co. (gift to 650 newspapermen at the First Imperial Press Conference, 1909, bankrolled by Harry Wellcome, whose Empire Press Union, 1909 newspapermen created British MI6, MI5 and CG&CS renamed GCHQ in 1946 with the founding of "Five Eyes" (UK, US, CA, NZ, and AU Commonwealth secret intelligence sharing)-wait, the U.S. is sovereign, right? Wrong. More at ...
Regan KH, Bhatt J. Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD009876. DOI: 10.1002/14651858.CD009876.pub3 ...
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function. Because of the resistance of BCC to many antibiotics, treatment options are often limited. New therapies to improve outcomes for patients infected with BCC are needed.. However, because of the unpredictable nature of this pulmonary infection in CF, patients with BCC infection have been excluded from many CF therapeutic trials.. Recent published trials in the United States, Australia, and the United Kingdom have all demonstrated clinical benefits from prolonged administration of azithromycin in CF. In these trials, the vast majority of patients were chronically infected with Pseudomonas aeruginosa.. Patients with BCC were excluded from the US and UK trials, and only four patients with BCC infection were enrolled in the Australian trial. Thus, the effectiveness of azithromycin in CF patients infected with BCC is largely unknown and deserves further ...
The fact that the 2030 Energy and Climate package includes an analysis of energy costs and was published together with the European Industrial Renaissance Communication is a landmark shift in EU policy. The Confederation of European Paper Industries (CEPI) interprets this as a signal showing the European Commission is starting to take industrial competitiveness seriously. However, there are still important steps to be taken.. In practice, this new package will not change the competitiveness of industry in the short run. The high pile of documents released by the Commission analyses and promises, but at the end it only proposes one legal act - the change of the EU ETS. In this regard, CEPI welcomes the Commission proposal to keep EU ETS unchanged up to 2020 to give the necessary stability for investments in EU industry. But is this enough?. The Commission finally acknowledged energy prices in Europe are uncompetitive, as electricity costs for industry are twice that of US competitors. It also ...
A World Economic Forum publication in collaboration with industry The European paper industry was invited to collaborate with the World Economic Forum (the Forum), the Ellen MacArthur Foundation and the McKinsey Center for Business and Environment on Circular Economy to produce a white paper with guidelines on design and management for circularity. The new publication provides essential guidance to all actors in the supply chain through simple ecodesign rules for paper products, without limiting innovation and the introduction of new techniques. This is a product of the three pilots under Project MainStream, launched during the 2014 summit in Davos.. "We trust helping circular thinking in all steps of the complex value chain will help reach higher in what is already a high recycling performance", said CEPI Sustainability Director Jori Ringman, one of the draftsmen of the guidance, in a panel discussion on the feasibility of higher recycling rates at the Packaging and Sustainability event in ...
Expression of BCAS1 (AIBC1, NABC1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Cystic fibrosis (CF) is a recessive genetic disease characterized by chronic respiratory infections and inflammation causing permanent lung damage. Recurrent infections are caused by Gram-negative antibiotic-resistant bacterial pathogens such as Pseudomonas aeruginosa, Burkholderia cepacia complex (Bcc) and the emerging pathogen genus Pandoraea. In this study, the interactions between co-colonizing CF pathogens were investigated. Both Pandoraea and Bcc elicited potent pro-inflammatory responses that were significantly greater than Ps. aeruginosa. The original aim was to examine whether combinations of pro-inflammatory pathogens would further exacerbate inflammation. In contrast, when these pathogens were colonized in the presence of Ps. aeruginosa the pro-inflammatory response was significantly decreased. Real-time PCR quantification of bacterial DNA from mixed cultures indicated that Ps. aeruginosa significantly inhibited the growth of Burkholderia multivorans, Burkholderia cenocepacia, Pandoraea
Burkholderia cepacia ATCC ® 17616D-5™ Designation: Genomic DNA from Burkholderia cepacia strain 249 TypeStrain=False Application:
Author Summary A regulatory protein can activate the expression of a target gene either directly, i.e., by binding to the genes promoter, or indirectly, i.e., by altering the expression of regulators, which, in turn, bind to the target genes promoter and induce or inhibit its transcription. Indirect regulatory circuits can contain multiple components and functional elements, such as feedforward and feedback loops. The complex structure of indirect regulation raises the question of its evolutionary origins. Here, we study the dynamic and evolutionary properties of regulatory architectures that involve members of the recently emerged class of bacterial proteins termed connectors. Such proteins post-translationally modulate the activity of two-component systems and phosphorelays, which constitute the prevalent form of bacterial signal transduction. We describe a novel connector-mediated regulatory circuit that combines the structural and functional properties of direct and indirect regulation. Our
Free Online Library: Environmental Burkholderia cepacia complex isolates in human infections.(DISPATCHES) by Emerging Infectious Diseases; Health, general Infection Health aspects
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Glowicz J, Crist M, Gould C, Moulton-Meissner H, Noble-Wang J, de Man TJB, Perry KA, Miller Z, Yang WC, Langille S, Ross J, Garcia B, Kim J, Epson E, Black S, Pacilli M, LiPuma JJ, Fagan R, B. cepacia Investigation Workgroup. 2018. A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016. Am J Infect Control 46:649-655.. Brooks RB, Mitchell PK, Miller JR, Vasquez AM, Havlicek J, Lee H, Quinn M, Adams E, Baker D, Greeley R, Ross K, Daskalaki I, Walrath J, Moulton-Meissner H, Crist MB, Burkholderia cepacia Workgroup. 2018. Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure to Contaminated Saline Flush Syringes - United States, 2016-2017. Clin Infect Dis Off Publ Infect Dis Soc Am.. Becker SL, Berger FK, Feldner SK, Karliova I, Haber M, Mellmann A, Schäfers H-J, Gärtner B. 2018. Outbreak of Burkholderia cepacia complex infections associated with ...
At the beginning of this review it is essential to clarify the terminology that will be used to refer to the members of the Burkholderia cepacia complex and their relatives. The name B. cepacia will relate only to B. cepacia genomovar I. Strains resembling B. cepacia may belong to the B. cepacia complex, to otherBurkholderia species (for instance, Burkholderia gladioli), or to species from other genera (for instance,Ralstonia pickettii) that share some phenotypic or genotypic similarities with the B. cepacia complex. B. cepacia complex bacteria and organisms that may be confused with them will be altogether referred to as B. cepacia-like organisms. Most previous reports regarding these organisms were published before the recognition of the complicated taxonomic relationships between the different members of the B. cepacia complex; it is therefore unclear to what category the presumed B. cepacia isolates described would belong. For that reason, when such literature is cited, the name "B. cepacia" ...
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B. cepacia complex bacteria can form biofilms, not only on abiotic surfaces (e.g., glass and plastics), but also on biotic surfaces such as epithelial cells, leading to the suggestion that biofilm formation plays a key role in persistent infection of cystic fibrosis lungs. This article presents an overview of the molecular mechanisms involved in B. cepacia complex biofilm formation, the increased resistance of sessile B. cepacia complex cells and the role of quorum sensing in B. cepacia complex biofilm formation.
Review question We looked for evidence of which antibiotics are best to treat a flare up of symptoms in people with cystic fibrosis with persistent Burkholderia cepacia complex lung infection.. Background Cystic fibrosis is a common inherited condition where the lungs often become blocked with mucus. This harms the lungs defences and often results in chronic, persistent infections that cannot be cleared by antibiotics. People with cystic fibrosis often need courses of antibiotics to reduce their symptoms (for instance cough, excess mucus and breathlessness) when these flare up or worsen. Such episodes are called exacerbations, and are usually treated with intravenous antibiotics (given through a drip into a vein). One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. They are ...
Review question. We reviewed the evidence for antibiotic treatment to cure early infection with Burkholderia cepacia complex in people with cystic fibrosis and prevent it becoming permanent.. Background. Cystic fibrosis is an inherited disease and people who have this disease produce large amounts of thick mucus which is difficult to clear. This mucus blocks up their lungs and digestive systems. People with cystic fibrosis suffer from lots of chest infections, which cause scarring of their airways. Eventually, they develop infections that cant be cured with antibiotics, so their lungs always contain lots of bugs, this is described as being chronically infected. One of these bugs, Burkholderia cepacia, causes a lot of problems for people with cystic fibrosis because it is very difficult to treat and makes their lung disease deteriorate faster than it otherwise would. This is an updated version of the review.. Search date. We last searched for any evidence on 12 March 2019.. Study ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717 ...
Lineage: cellular organisms; Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex; Burkholderia ...
Bcas2 - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN302083G1|/strong|, Bcas2 gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
Development and validation of |i|Burkholderia pseudomallei|/i|-specific real-time PCR assays for clinical, environmental or forensic detection applications
This policy does not require BCAM to engage in exhaustive review of every corporation in order to trace the sources of income, but recognizes that the activities of many corporations change rapidly , and that BCAM will periodically need to evaluate new information about corporate donors and the implications of that information. We encourage our members and others to provide information about corporate activities that they believe have a bearing on this policy.. BCAM will continue to focus its fundraising efforts on individual giving, either through direct contributions or through workplace giving programs, as well as corporate donations from industries other than those listed above. This policy shall not be construed to prohibit BCAM from accepting: (a) matching gifts from corporations that are initiated by donations from an individual corporate employee or a group of corporate employees, or b) corporate contributions made in memory or honour of someone, at the request of the honoree, or of the ...
Mouse monoclonal antibody raised against a full-length recombinant BCAS4. BCAS4 (AAH38381.1, 1 a.a. ~ 173 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00055653-M03) - Products - Abnova
Nicholson, Audrey, Perry, John, James, Arthur, Stanforth, Stephen, Carnell, Sonya, Wilkinson, Kathryn, Khan, Anjam, de Soyza, Anthony and Gould, Kate (2012) In vitro activity of S-(3,4-dichlorobenzyl) isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. International Journal of Antimicrobial Agents, 39 (1). pp. 27-32. ISSN 0924-8579 de Soyza, Anthony, Meachery, Gerard, Hester, Katy, Nicholson, Audrey, Parry, Gareth, Tocewicz, Krzysztof, Pillay, Thasee, Clark, Stephen, Lordan, James, Schueler, Stephan, Fisher, Andrew, Dark, John, Gould, Kate and Corris, Paul (2010) Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience. The Journal of Heart and Lung Transplantation, 29 (12). pp. 1395-1404. ISSN 1053 2498 Meachery, Gerard, de Soyza, Anthony, Nicholson, Audrey, Parry, Gareth, Hasan, Asif, Tocewicz, Krzysztof, ...
Easton A, Haque https://www.ncbi.nlm.nih.gov/pubmed/?term=19829050%5Bpmid%5DA, Chu K, Lukaszewski R, Bancroft GJ. 2007. A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. J Infect Dis 195: 99-107. A Critical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei. ...
Nurse Assist voluntarily recalled its I.V. Flush Syringes after becoming aware of patients that developed Burkholderia cepacia bloodstream infections while receiving intravenous care using prepackaged saline flushes from Nurse Assist. Nurse Assist is notifying its distributors and customers via email, phone call, and certified mail. Customers will receive instructions for returning product. For freight collect shipping information, please contact the Customer Service Team at 1-800-649-6800 ext. 10.. Nurse Assist is actively investigating the possible link to the infections with the Food and Drug Administration, the U.S. Centers for Disease Control, and various state health departments to ensure that the products are safe for their intended use. Until an investigation can be completed, Nurse Assist urges all healthcare facilities with affected product to discontinue use and return the product to the supplier.. Consumers with questions may contact the company via telephone at 1-800-649-6800 ext. ...
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Frontiers | 3-Hydroxyphenylacetic Acid Induces the Burkholderia cenocepacia Phenylacetic Acid Degradation Pathway - Toward...Frontiers | 3-Hydroxyphenylacetic Acid Induces the Burkholderia cenocepacia Phenylacetic Acid Degradation Pathway - Toward...

We previously made a link in Burkholderia cenocepacia between phenylacetic acid (PA) degradation and virulence by showing that ... induces the phenylacetic acid degradative pathway in Burkholderia cenocepacia K56-2. Using reporter activity assays, we show ... induces the phenylacetic acid degradative pathway in Burkholderia cenocepacia K56-2. Using reporter activity assays, we show ... We previously made a link in Burkholderia cenocepacia between phenylacetic acid (PA) degradation and virulence by showing that ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2011.00014/full

Scientific Articles - The International Burkholderia cepacia Working GroupScientific Articles - The International Burkholderia cepacia Working Group

Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing. Proc Natl Acad Sci U S A 106:3976-3981. ... Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing. Proc Natl Acad Sci U S A 106:3976-3981. ... Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo. Sci Rep 6:32487. ... The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of ...
more infohttps://ibcwg.org/index.php/home/publications/

Burkholderia cenocepacia - WikipediaBurkholderia cenocepacia - Wikipedia

"Burkholderia cenocepacia". NCBI Taxonomy Browser. 95486. Type strain of Burkholderia cenocepacia at BacDive - the Bacterial ... is Burkholderia cenocepacia, a member of a bacterial group collectively referred to as the Burkholderia cepacia complex (Bcc ... Burkholderia cenocepacia is a species of Gram-negative bacteria that is common in the environment, can form a biofilm with ... Burkholderia cenocepacia is a Gram-negative bacterium with the ability to form a biofilm Nida H. Alshraiedeh; Sarah ...
more infohttps://en.wikipedia.org/wiki/Burkholderia_cenocepacia

Burkholderia cenocepacia ATCC ® BAA-245D-5™Burkholderia cenocepacia ATCC ® BAA-245D-5™

Genomic DNA from Burkholderia cenocepacia strain LMG 16656 TypeStrain=False Application: ... Burkholderia cenocepacia (ATCC® BAA-245D-5™) Strain Designations: Genomic DNA from Burkholderia cenocepacia strain LMG 16656 [ ... Burkholderia cepacia (Palleroni and Holmes) Yabuuchi et al. Strain Designations Genomic DNA from Burkholderia cenocepacia ... Burkholderia cenocepacia ATCC® BAA-245D-5™ dried Total DNA: At least 5 µg in 1X TE buffer ...
more infohttps://www.atcc.org/en/Products/Cells_and_Microorganisms/Bacteria/Bacterial_Nucleic_Acids/BAA-245D-5.aspx

KEGG PATHWAY: Glycolysis / Gluconeogenesis - Burkholderia cenocepacia J2315KEGG PATHWAY: Glycolysis / Gluconeogenesis - Burkholderia cenocepacia J2315

Glycolysis / Gluconeogenesis - Burkholderia cenocepacia J2315 [ Pathway menu , Organism menu , Pathway entry , Download KGML , ...
more infohttp://www.genome.jp/kegg-bin/show_pathway?bcj00010+BCAL2623

KEGG PATHWAY: Methane metabolism - Burkholderia cenocepacia J2315KEGG PATHWAY: Methane metabolism - Burkholderia cenocepacia J2315

Methane metabolism - Burkholderia cenocepacia J2315 [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ...
more infohttp://www.genome.jp/kegg-bin/show_pathway?bcj00680+BCAL0739

Burkholderia cenocepacia sp. nov.--a new twist to an old story.  - PubMed - NCBIBurkholderia cenocepacia sp. nov.--a new twist to an old story. - PubMed - NCBI

Burkholderia cenocepacia sp. nov.--a new twist to an old story.. Vandamme P1, Holmes B, Coenye T, Goris J, Mahenthiralingam E, ... DNA-DNA hybridisation experiments between isolates representing Burkholderia cepacia genomovar III recA lineages IIIA and IIIB ... cenocepacia sp. nov., with LMG 16656 as the type strain, is proposed. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12648723?dopt=Abstract

ureA - Urease subunit gamma - Burkholderia cenocepacia (strain HI2424) - ureA gene & proteinureA - Urease subunit gamma - Burkholderia cenocepacia (strain HI2424) - ureA gene & protein

sp,A0K578,URE3_BURCH Urease subunit gamma OS=Burkholderia cenocepacia (strain HI2424) OX=331272 GN=ureA PE=3 SV=1 ... Burkholderia cenocepacia (strain HI2424). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_ ... cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › ...
more infohttps://www.uniprot.org/uniprot/A0K578

DF049 32645 - 2-hydroxyacid dehydrogenase - Burkholderia cenocepacia - DF049 32645 gene & proteinDF049 32645 - 2-hydroxyacid dehydrogenase - Burkholderia cenocepacia - DF049 32645 gene & protein

tr,A0A3N9DMI2,A0A3N9DMI2_9BURK 2-hydroxyacid dehydrogenase OS=Burkholderia cenocepacia OX=95486 GN=DF049_32645 PE=4 SV=1 ... cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › ...
more infohttps://www.uniprot.org/uniprot/A0A3N9DMI2

The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients | Journal of BacteriologyThe Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients | Journal of Bacteriology

Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov., ... Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax 59:948-951. ... CDSs with matches identified by reciprocal FASTA with other Burkholderia species-B. cenocepacia HI2424, B. cenocepacia AU1054, ... cenocepacia island (CCI), are more frequently associated with B. cenocepacia IIIA strains than other B. cenocepacia recA ...
more infohttps://jb.asm.org/content/191/1/261?ijkey=422e032f7b02c0d820925b5c7da825dce7ac2820&keytype2=tf_ipsecsha

LPXC Recombinant Protein (Burkholderia cenocepacia) (OPCA05248) | E.coli Expressed Purified ProteinLPXC Recombinant Protein (Burkholderia cenocepacia) (OPCA05248) | E.coli Expressed Purified Protein

Burkholderia cenocepacia) (OPCA05248) , Alias: UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase , MW: 51.00630092 ... Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia ( ... The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.. Holden M.T., Seth-Smith H.M., ...
more infohttps://www.avivasysbio.com/en/lpxc-recombinant-protein-burkholderia-cenocepacia-opca05248.html

The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia |...The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia |...

Burkholderia cenocepacia is a member of the B. cepacia complex, a diverse group of bacteria with important clinical ... J. J. LiPuma, and P. Vandamme, 2004 Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe. ... The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia. ... The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia. ...
more infohttps://www.genetics.org/content/200/3/935?ijkey=5ac4ee28922327b0cf9bff8ecd1e46cc3057bac7&keytype2=tf_ipsecsha

Identification of Essential Operons with a Rhamnose-Inducible Promoter in Burkholderia cenocepacia | Applied and Environmental...Identification of Essential Operons with a Rhamnose-Inducible Promoter in Burkholderia cenocepacia | Applied and Environmental...

Identification of Essential Operons with a Rhamnose-Inducible Promoter in Burkholderia cenocepacia. Silvia T. Cardona, Carmen L ... Identification of essential genes and essential operons in B. cenocepacia K56-2.Based on the previous results, B. cenocepacia ... Identification of Essential Operons with a Rhamnose-Inducible Promoter in Burkholderia cenocepacia ... Identification of Essential Operons with a Rhamnose-Inducible Promoter in Burkholderia cenocepacia ...
more infohttps://aem.asm.org/content/72/4/2547?ijkey=6cd6e191a0b1fe59292b537a9a2dfcb0b0905cad&keytype2=tf_ipsecsha

Burkholderia cenocepacia Vaginal Infection in Patient with Smoldering Myeloma and Chronic Hepatitis C - Volume 10, Number 11...Burkholderia cenocepacia Vaginal Infection in Patient with Smoldering Myeloma and Chronic Hepatitis C - Volume 10, Number 11...

Treatment with piperacillin/tazobactam eliminated B. cenocepacia infection and vaginal symptoms ... We report a case of a vaginal infection caused by a strain of Burkholderia cenocepacia. The strain was isolated from vaginal ... Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, Burkholderia cepacia genomovars I and III. J Clin ... Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound ...
more infohttps://wwwnc.cdc.gov/eid/article/10/11/04-0127

The intracellular behaviour of Burkholderia cenocepacia in murine macrophages by Jennifer S. Tolman"The intracellular behaviour of Burkholderia cenocepacia in murine macrophages" by Jennifer S. Tolman

... cenocepacia-containing phagosome. We hypothesize that B. cenocepacia alters gene expression after internalization by ... In this work, we characterize later-stage infection of macrophages by B. cenocepacia, showing replication within an acidified ... As a whole, secretion systems appear to increase pathogenicity in macrophages while limiting the spread of B. cenocepacia ... Expression of secretion system genes is differentially-regulated by intracellular B. cenocepacia. Although none of the five ...
more infohttps://ir.lib.uwo.ca/etd/338/

σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111 | Applied and Environmental...σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111 | Applied and Environmental...

σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111. Martina Lardi, Claudio ... S1); consensus sequence logo for the B. cenocepacia H111 σ54-binding site (Fig. S2); growth delay of the B. cenocepacia H111 σ ... σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111 ... σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111 ...
more infohttps://aem.asm.org/content/81/12/4077/figures-only

Intraspecies Signaling Involving the Diffusible Signal Factor BDSF (cis-2-Dodecenoic Acid) Influences Virulence in Burkholderia...Intraspecies Signaling Involving the Diffusible Signal Factor BDSF (cis-2-Dodecenoic Acid) Influences Virulence in Burkholderia...

Virulence of Burkholderia cenocepacia strains in the Galleria mellonella larva infection model. Larvae were injected with 106 ... A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME J. 2:27- ... Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been ... The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J. Bacteriol. 191:261-277. ...
more infohttps://jb.asm.org/content/191/15/5013

Frontiers | Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a...Frontiers | Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a...

In this work, we investigated the lipopolysaccharide (LPS) of clinical variants of B. cenocepacia that were collected from a ... In this work, we investigated the lipopolysaccharide (LPS) of clinical variants of B. cenocepacia that were collected from a ... cenocepacia. The IST439 OAg biosynthetic gene cluster contains 7 of 23 genes that are closely homologous to genes found in B. ... cenocepacia. The IST439 OAg biosynthetic gene cluster contains 7 of 23 genes that are closely homologous to genes found in B. ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2017.01027/full

Quorum-sensing mutations affect attachment and stability of Burkholderia cenocepacia biofilms  - Enlighten: PublicationsQuorum-sensing mutations affect attachment and stability of Burkholderia cenocepacia biofilms - Enlighten: Publications

Quorum-sensing mutations affect attachment and stability of Burkholderia cenocepacia biofilms. Applied and Environmental ...
more infohttp://eprints.gla.ac.uk/22445/

Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of...Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of...

Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of ... "Identification of a Novel Virulence Factor in Burkholderia Cenocepacia H111 Required for Efficient Slow Killing of ... Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of ... "Identification of a Novel Virulence Factor in Burkholderia Cenocepacia H111 Required for Efficient Slow Killing of ...
more infohttps://biblio.ugent.be/publication/305399

Differential Roles of RND Efflux Pumps in Antimicrobial Drug Resistance of Sessile and Planktonic Burkholderia cenocepacia...Differential Roles of RND Efflux Pumps in Antimicrobial Drug Resistance of Sessile and Planktonic Burkholderia cenocepacia...

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome. BMC Microbiol. 6:66. doi: ... Deciphering the role of RND efflux transporters in Burkholderia cenocepacia. PLoS One 6:e18902. doi:10.1371/journal.pone. ... Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence. Pathog. Dis. 71:326-335. doi:10.1111/ ... Evaluation of the efficacy of disinfection procedures against Burkholderia cenocepacia biofilms. J. Hosp. Infect. 70:361-368. ...
more infohttps://aac.asm.org/content/58/12/7424

Recombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1) - CusabioRecombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1) - Cusabio

Purchase Recombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1). It is produced in Yeast. High purity ... Recombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1). Recombinant Burkholderia cenocepacia ... Recombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1),E.coli. ... Recombinant Burkholderia cenocepacia Translation initiation factor IF-1 1(infA1),Mammalian cell. ...
more infohttps://www.cusabio.com/Recombinant-Protein/Recombinant-Burkholderia-cenocepacia-Translation-initiation-factor-IF-1-1infA1-347867.html

Overview: tagF, Burkholderia cenocepacia J2315
	Overview: tagF, Burkholderia cenocepacia J2315

The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. Bioinformatics 2008 Dec 1;24(23):2803 ... If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than ... kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia. ... Burkholderia cenocepacia J2315, BCAL0350 (tagF) .list-group { margin-bottom: 5px; width: 150px; text-align: left; } Cytoplasmic ...
more infohttp://beta.burkholderia.com/feature/show?id=557339

Overview: acpP, Burkholderia cenocepacia J2315
	Overview: acpP, Burkholderia cenocepacia J2315

Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials development? ... The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. Bioinformatics 2008 Dec 1;24(23):2803 ... If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than ... Burkholderia cenocepacia J2315, BCAL0995 (acpP) .list-group { margin-bottom: 5px; width: 150px; text-align: left; } Cytoplasmic ...
more infohttps://burkholderia.com/feature/show?id=558619

Overview: BCAL0021, Burkholderia cenocepacia J2315
	Overview: BCAL0021, Burkholderia cenocepacia J2315

The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. Bioinformatics 2008 Dec 1;24(23):2803 ... If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than ...
more infohttp://beta.burkholderia.com/feature/show/?locus_tag=BCAL0021
  • We previously made a link in Burkholderia cenocepacia between PA degradation and virulence by showing that insertional mutagenesis of paaA and paaE genes, that encode part of a multicomponent oxidase of PA-CoA, results in PA-conditional growth and an attenuated killing phenotype in the Caenorhabditis elegans model of infection. (frontiersin.org)
  • 2016. Burkholderia contaminans Colonization from Contaminated Liquid Docusate (Colace) in a Immunocompetent Adult with Legionnaire's Disease: Infection Control Implications and the Potential Role of Candida pellucosa. (ibcwg.org)
  • Using reporter activity assays, we demonstrate that 3-OHPA activated PA degradation gene promoters of Burkholderia cenocepacia K56-2 in a paaK1 -dependent manner, while 4-OHPA had no effect. (frontiersin.org)
  • In this work, we aimed to determine the relevance of PaaK1 activity to the killing ability of B. cenocepacia to C. elegans . (frontiersin.org)
  • Recently, Law and Boulanger (2011) provided a rationale for the presence of the two-paralog PA-CoA ligases of B. cenocepacia by in vitro studies, showing that PaaK1 has a much higher affinity for PA than PaaK2 with K m values of 62 and 150 μM, respectively. (frontiersin.org)
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