A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.
A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.
A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.
Infections with bacteria of the genus BURKHOLDERIA.
A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.
A species of gram-negative, aerobic bacteria that causes MELIOIDOSIS. It has been isolated from soil and water in tropical regions, particularly Southeast Asia.
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.
A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
A sulfanilamide that is used as an antibacterial agent.
A mitosporic Ceratobasidiaceae fungal genus that is an important plant pathogen affecting potatoes and other plants. There are numerous teleomorphs.
Proteins found in any species of bacterium.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
A species of gram-negative, aerobic bacteria that acts as both a human and plant pathogen.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
The functional hereditary units of BACTERIA.
A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.
Fatty acids which are unsaturated in only one position.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The genetic complement of a BACTERIA as represented in its DNA.
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Substances that reduce the growth or reproduction of BACTERIA.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
Membrane-bound cytoplasmic vesicles formed by invagination of phagocytized material. They fuse with lysosomes to form phagolysosomes in which the hydrolytic enzymes of the lysosome digest the phagocytized material.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.

BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB. (1/74)

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Ecological succession in long-term experimentally evolved biofilms produces synergistic communities. (2/74)

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Inactivation of macrophage Rab7 by Burkholderia cenocepacia. (3/74)

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The pobA gene of Burkholderia cenocepacia encodes a group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin. (4/74)

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The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes. (5/74)

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Virulence of an emerging respiratory pathogen, genus Pandoraea, in vivo and its interactions with lung epithelial cells. (6/74)

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Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. (7/74)

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CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. (8/74)

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Burkholderia cepacia has emerged during the past 2 decades as an important opportunistic pathogen in persons with cystic fibrosis (CF) (11). Although B. cepacia was previously regarded as a single species, recent taxonomic studies have identified at least nine closely related species in what is now referred to as the B. cepacia complex (Bcc). This group includes B. cepacia, Burkholderia multivorans, Burkholderia cenocepacia, Burkholderia stabilis, Burkholderia vietnamiensis, Burkholderia dolosa, Burkholderia ambifaria, Burkholderia anthina, and Burkholderia pyrrocinia (4-6, 25, 28-32). Although each of these species has been recovered from respiratory secretions of persons with CF, B. multivorans and B. cenocepacia account for the great majority of isolates (12, 24). Mounting evidence also suggests that B. cenocepacia is somewhat more pathogenic in CF than are the remaining species (1, 8).. A feature that distinguishes Bcc from other pathogens in CF is the occurrence in a significant proportion ...
In a previous study, we identified a gene, BCAM0224, encoding a trimeric autotransporter adhesin (TAA), which appears to be restricted to epidemic-associated B. cenocepacia strains of the ET-12 lineage (22). Transcriptional analysis revealed that BCAM0224 is located within a bicistronic operon composed of 9 genes, which comprises, among others, two additional TAA-encoding genes (BCAM0219 and BCAM0223) (21). In an attempt to characterize the functions of the TAA-encoding genes in B. cenocepacia, we have generated mutations and analyzed the associated phenotypes. Based on this, we previously proposed that the BCAM0224 protein is involved in virulence, since the BCAM0224 mutant was less virulent than the wild-type strain in an insect infection model (22). In addition, disruption of the BCAM0223 gene impairs the ability of the mutant strain to adhere to epithelial cells, decreases serum resistance, and reduces virulence (21). Finally, in a recent report, we used atomic force microscopy (AFM) to ...
TY - JOUR. T1 - A Decade of Burkholderia cenocepacia Virulence Determinant Research. AU - Loutet, S.A.. AU - Valvano, Miguel. PY - 2010/10. Y1 - 2010/10. N2 - The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases. These infections are difficult to treat due to the inherent resistance of the bacteria to antibiotics. Bacteria can spread between CF patients through social contact and sometimes cause cepacia syndrome, a fatal pneumonia accompanied by septicemia. Burkholderia cenocepacia has been the focus of attention because initially it was the most common Bcc species isolated from patients with CF in North America and Europe. Today, B. cenocepacia, along with Burkholderia multivorans, is the most prevalent Bcc species in patients with CF. Given the progress that has been made in our understanding of B. cenocepacia over the past decade, we ...
Mapping transcription start sites across the B. cenocepacia genome added relevant information to the J2315 annotation. Genes and novel regulatory RNAs putatively involved in B. cenocepacia biofilm formation were identified. These findings will help in understanding regulation of B. cenocepacia biofi …
The cciIR quorum-sensing system associated with epidemic strains of B. cenocepacia is involved in the regulation of known virulence factors and is a part of a regulatory network with the cepIR quorum-sensing system, since CepR is required for cciIR expression. Phylogenetic analysis demonstrated that the cepIR and cciIR systems are highly distinct. The cepIR system that is widely distributed among the Bcc was predicted to be the ancestral system, whereas the cciIR system was likely acquired by horizontal gene transfer when cci was incorporated into the B. cenocepacia genome. The presence of an ancestral and a more-recently acquired AHL-dependent quorum-sensing system has been observed in other species. The P. aeruginosa lasIR system is considered to be the ancestral system, and the rhlIR system is considered to be more recently acquired (22). The rhlIR system has been incorporated into the regulatory pathway of the lasIR system and is dependent on the lasIR system for expression (21, 34). Both of ...
Burkholderia cenocepacia ATCC ® BAA-245D-5™ Designation: Genomic DNA from Burkholderia cenocepacia strain LMG 16656 TypeStrain=False Application:
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Burkholderia cenocepacia is a Gram-negative aerobic bacterium that belongs to a group of opportunistic pathogens displaying diverse environmental and pathogenic lifestyles. B. cenocepacia is known for its ability to cause lung infections in people with cystic fibrosis and it possesses a large 8 Mb multireplicon genome encoding a wide array of pathogenicity and fitness genes. Transcriptomic profiling across nine growth conditions was performed to identify the global gene expression changes made when B. cenocepacia changes niches from an environmental lifestyle to infection. In comparison to exponential growth, the results demonstrated that B. cenocepacia changes expression of over one-quarter of its genome during conditions of growth arrest, stationary phase and surprisingly, under reduced oxygen concentrations (6% instead of 20.9% normal atmospheric conditions). Multiple virulence factors are upregulated during these growth arrest conditions. A unique discovery from the comparative expression ...
Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in cystic fibrosis and other immunocompromised patients. The bacterium survives within macrophages by interfering with typical endocytic trafficking, resulting in delayed maturation of a B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia alters gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation. Furthermore, we hypothesize that specialized bacterial secretion systems are involved in the interactions between intracellular bacteria and macrophages. In this work, we characterize later-stage infection of macrophages by B. cenocepacia, showing replication within an acidified endosomal compartment suggestive of a phagolysosome. We examine differential gene expression by intracellular B. cenocepacia using selective capture of transcribed sequences (SCOTS) with both competitive enrichment and microarray analysis. We identified 766
Since bceU is found in the genome sequences of all Bcc strains as well as in B. thailandensis, B. oklahomensis, and B. pseudomallei strains, the authors of PMID:19948863 considered it to belong as part of bce-II gene cluster ...
Dr Heather Wilson1, Dr Karina Kennedy1, Ms Shannon Broadrick1, Ms Fiona Kimber1, Ms Wendy Beckingham1, Prof Peter Collignon1. 1Canberra Hospital And Health Services, Canberra, Australia. Introduction:. Burkholderia cenocepacia is an environmental organism and an unusual isolate from blood, although is a recognised cause of nosocomial outbreaks due to contamination of various fluids. B. cenocepacia bacteraemia in two patients in the Canberra Hospital ICU prompted an investigation into a common source.. Methods:. Clinical and epidemiological data were obtained from the patients medical records. Clinical and environmental specimens were cultured and identified by MALDI-TOF (Bruker). Further characterisation, using recA gene sequencing and whole genome sequencing, was performed at Queensland Pathology.. Results:. The finding that our two patients occupied the same bed within hours of having the blood cultures collected directed environmental testing of the area. B. cepacia complex was grown from a ...
Purchase Recombinant Burkholderia cenocepacia ATP-dependent Clp protease adapter protein ClpS(clpS). It is produced in Yeast. High purity. Good price.
Please Note: Ortholuge cannot be used for certain RBB analyses involving closely-related strains (e.g. Burkholderia cenocepacia J2315 versus Burkholderia cenocepacia AU 1054) because the phylogenetic distance between each ingroup protein is very small in relation to the phylogenetic distance between each ingroup protein and the associated outgroup protein. In these cases, the Ortholuge Classification value will be left blank which indicates Ortholuge analysis was not peformed, however the two proteins may very well be orthologs. In other cases, only some rows will be missing Ortholuge classifications, which can occur when a suitable gene could not be found in the outgroup species ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Scientists may have found a way to kill Burkholderia cenocepacia, a multi-drug resistant plant pathogen that causes severe infections in people with cystic fibrosis.. The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics. Researchers hope to discover novel molecules as antibiotic candidates which could disrupt the synthesis of Ara4N.. ...
SWISS-MODEL Repository entry for A0K923 (NUOA_BURCH), NADH-quinone oxidoreductase subunit A. Burkholderia cenocepacia (strain HI2424)
SWISS-MODEL Repository entry for A0K968 (Y2294_BURCH), Probable transcriptional regulatory protein Bcen2424_2294. Burkholderia cenocepacia (strain HI2424)
Joseph D. Mougous and coworkers at the University of Washington School of Medicine and HHMI discovered a cytidine deaminase, which converts cytosine (C) to uracil (U), in the bacteria Burkholderia cenocepacia and thought the enzyme could be useful for genome editing. Mougous reached out to David R. Liu at the Broad Institute, Harvard University, and HHMI, because Lius group had previously developed base editors, which are engineered proteins that make specific single-letter changes in DNA.. ...
We report a case of a vaginal infection caused by a strain of Burkholderia cenocepacia. The strain was isolated from vaginal swab specimens from a 68-year-old woman with smoldering myeloma and chronic hepatitis C virus infection who was hospitalized ...
4B6Z: High-Resolution Structure of the M14-Type Cytosolic Carboxypeptidase from Burkholderia Cenocepacia Refined Exploiting Pdb_Redo Strategies.
Zaradi pogoste uporabe betalaktamskih zdravil so nekatere bakterije razvile odpornost proti njim. Nekatere bakterije proizvajajo prej omejeni encim betalaktamazo, ki izniči učinek betalaktamskega antibiotika, ker cepi betalaktamski obroč.. Za preprečitev tovrstne odpornosti bakterij so na trgu kombinacije betalaktamskih antibiotikov z zaviralci betalaktamaze. Takšna kombinacija je npr. amoksicilin + klavulanska kislina. Klavulanska kislina je zaviralec betalaktamaze, ker se nepovratno veže na encim in slednji se več ne more vezati na betalaktamsko učinkovino (v tem primeru amoksicilin).. ...
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The phenylacetic acid (PA) degradative pathway is the central pathway by which complex aromatic compounds (e.g. styrene) get degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA, which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made a link in Burkholderia cenocepacia between phenylacetic acid (PA) degradation and virulence by showing that insertional mutagenesis of paaA and paaE results in PA-conditional growth and an attenuated killing phenotype in the Caenorhabditis elegans model of infection. Insertional mutagenesis of paaK1, which encodes a phenylacetyl-CoA ligase, did not result in a PA-conditional growth probably due to the presence of a second similar gene (paaK2) encoding another phenylacetyl-CoA ligase (PaaK2). Recently published crystallographic and enzyme kinetics studies comparing the two ligases show that PaaK1 is better able to bind hydroxylated PA derived molecules such as 3-hydroxyphenylacetic (3-OHPA) acid and
Essential gene studies often reveal novel essential functions for genes with dispensable homologues in other species. This is the case with the widespread family of electron transfer flavoproteins (ETFs), which are required for the metabolism of specific substrates or for symbiotic nitrogen fixation in some bacteria. Despite these non-essential functions high-throughput screens have identified ETFs as putatively essential in several species. In this study, we constructed a conditional expression mutant of one of the ETFs in Burkholderia cenocepacia, and demonstrated that its expression is essential for growth on both complex media and a variety of single-carbon sources. We further demonstrated that the two subunits EtfA and EtfB interact with each other, and that cells depleted of ETF are non-viable and lack redox potential. These cells also transition from the short rods characteristic of Burkholderia cenocepacia to small spheres independently of MreB. The putative membrane partner ETF dehydrogenase
O -linked protein glycosylation is a conserved feature of the Burkholderia genus. For Burkholderia cenocepacia , the addition of the trisaccharide β-G
Acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a triazole group were synthesized and evaluated for their effect on quorum sensing (QS) and biofilm formation in Burkholderia cenocepacia and Pseudomonas aeruginosa. In addition, the influence of the length of the acyl-mimicking chain was investigated. The compounds showed selectivity between two different AHL QS systems. 3-(1H-1,2,3-Triazol-1-yl)dihydrofuran-2(3H)-ones, in which the 4-substituent best resembled the acyl chain of the native AHL molecule exhibited significant QS agonistic and antagonistic activities. Replacing this aliphatic substituent by a phenyl-containing moiety resulted in active inhibitors of QS. The most active compounds showed biofilm inhibitory as well as biofilm eradicating activities in both test organisms. ...
DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays. It is well documented that 25mer probes directed against different regions of the same gene produce variable signal intensity values. However, the extent to which this is true for probes of greater length (60mers) is not well characterized. Moreover, this information has not previously been reported for whole-genome arrays designed against bacteria, whose genomes may differ substantially in characteristics directly affecting microarray performance. We report here an analysis of alternative 60mer probe designs for an in-situ synthesized oligonucleotide array for the GC rich, β-proteobacterium Burkholderia cenocepacia. Probes were designed using the ArrayOligoSel3.5 software package and whole-genome microarrays synthesized by Agilent, Inc. using their in-situ, ink-jet technology platform. We first validated the quality of the microarrays as demonstrated by an average
Survival curves for D. melanogaster infected with B. cenocepacia strains.Pricking assays were performed with a minimum of 30 flies for each strain. Statistical
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TY - CONF. T1 - Comparison of biofilm formation between Burkholderia multivorans Burkholderia cenocepacia Pseudomonas aeruginosa in the presence or absence of mucin. AU - Einarsson, Gisli. AU - McDowell, Andrew. AU - Elborn, Joseph. AU - Martin, Lorraine. PY - 2009/6. Y1 - 2009/6. M3 - Paper. SP - S34-S34. T2 - European Cystic Fibrosis Conference. Y2 - 1 June 2009 through 1 June 2009. ER - ...
Aabed, Tariq Ahmad (2018) Radiation Effects on Mesenchymal Stem Cells in a Model of Fibrosarcoma. PhD thesis, University of Sheffield. Albaz, Alrayan (2018) Investigation into Cytosine Epigenetic State in Bladder Cancer. PhD thesis, University of Sheffield. Aljadani, Saeedah (2018) Regulation of iron acquisition by an iron starvation sigma factor system in Burkholderia cenocepacia. PhD thesis, University of Sheffield. Alkathiri, Afnan (2018) Investigation the Role of ATM in Sarcomas. PhD thesis, University of Sheffield. Allocca, Gloria (2018) Defining the perivascular niche in the early stages of breast cancer bone metastasis. PhD thesis, University of Sheffield. Almaghrabi, Sarah (2018) Gene Therapy for an Experimental Autoimmune Polyglandular Syndrome 1 Model Caused by Mutations in Aire. PhD thesis, University of Sheffield. Alrahimi, Jehan (2018) The Role of Tetraspanins in Pseudomonas aeruginosa Adherence to Human Cells. PhD thesis, University of Sheffield. Alshamrani, Khalaf (2018) ...
This pipeline reflects, to the best of our knowledge, publicly available information on the status of vaccine candidates with a direction towards human use for Lassa and Nipah (as at August 2017) and for MERS-CoV (as at July 2017). Please contact [email protected] if you have evidence to report on updates to this.. ...
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Zaviralci proteaz ali proteazni zaviralci (oznaka ATC: J05AE) so skupina učinkovin za zdravljenje ali preprečevanje virusnih okužb, vključno z okužbami z virusom HIV in virusom hepatitisa C. Preprečujejo virusno podvojevanje, tako da zavrejo delovanje encima proteaze (npr. proteaze HIV-1, ki cepi nastajajoče beljakovine, ki se nato združujejo in tvorijo virione). Doslej so razvili oziroma so v fazi razvoja proteazni zaviralci za naslednje virusne okužbe:: ...
General Information: Burkholderia cenocepacia MC0-3 was isolated from soil associated with maize roots. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients. ...
Chronic pulmonary infections are the principal cause of morbidity and mortality in individuals with cystic fibrosis (CF). Due to the polymicrobial nature of these infections, the identification of the particular bacterial species responsible is an essential step in diagnosis and treatment. Current diagnostic procedures are time-consuming, and can also be expensive, invasive and unpleasant in the absence of spontaneously expectorated sputum. The development of a rapid, non-invasive methodology capable of diagnosing and monitoring early bacterial infection is desired. Future visions of real-time, in situ diagnosis via exhaled breath testing rely on the differentiation of bacteria based on their volatile metabolites. The objective of this proof-of-concept study was to investigate whether a range of CF-associated bacterial species (i.e. Pseudomonas aeruginosa, Burkholderia cenocepacia, Haemophilus influenzae, Stenotrophomonas maltophilia, Streptococcus pneumoniae and Streptococcus milleri) could be ...
The RNA Printer™ is capable of producing several grams of LNP-formulated mRNA (enough to produce more than a hundred thousand doses), within just a few weeks. This platform can also produce mRNA vaccine candidates against multiple pathogens using the same technology, saving time and reducing costs compared with other vaccine platforms.. CureVacs vaccine platform could be a game-changer, radically improving our ability to respond to the emergence of Disease X, said Richard Hatchett, CEO of CEPI. Disease X could emerge suddenly and have deadly consquences-weve seen this happen with Ebola, MERS coronavirus, Zika, and countless other diseases. Thats why were striving to develop rapid-response vaccine platforms-like CureVacs mRNA technology-to defend against these unknown pathogens. CEPI has now established partnership agreements totaling more than $50 million in three such platforms.. CureVacs mRNA technology can be designed to encode for many proteins or antigens, offering rich ...
Ah, yes! Im dealing with Burkholderia. 16s rDNA analyses showed similarity to B. cepacia and B. cenocepacia. Perhaps the fact that B. cepacia exists as a complex of many strains (genomovars) that makes biochemical identification inaccurate; what more when I did it the conventional way. Hoping this time that the commercial kit like API could back the 16s analyses up.. ...
Blog on BCAS2 recombinant protein product: The BCAS2 bcas2 (Catalog #MBS203900) is a Recombinant Protein and is intended for research purposes only....
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Co-led by Gavi, the Coalition for Epidemic Preparedness Innovations (CEPI) and WHO, COVAX aims to accelerate the development and manufacture of COVID-19 vaccines while guaranteeing fair and equitable access for every country.
The Burkholderia cepacia complex consists of nine closely related species: Burkholderia cepacia genomovars I and VI, Burkholderia multivorans (genomovar II), Burkholderia cenocepacia (genomovar III), Burkholderia stabilis (genomovar IV), Burkholderia vietnamiensis (genomovar V), Burkholderia ambifaria (genomovar VII), Burkholderia anthina (genomovar VIII), and Burkholderia pyrrocinia (genomovar IX) (2, 9, 10). Despite the advances that have been made in the understanding of the taxonomy and epidemiology of this group, infections of the respiratory tract with B. cepacia complex organisms still have a considerable impact on morbidity and mortality in cystic fibrosis (CF) patients (4, 5, 6). B. cepacia complex strains have also attracted attention as possible biocontrol and bioremediation agents that could be used as antagonists of soil-borne plant pathogens, as plant growth-promoting agents, and for the bioremediation of various recalcitrant xenobiotics (3, 8). To aid in identification, ...
This study aimed firstly to establish the distribution and copy number within the Burkholderia cepacia complex of three insertion sequences (IS402, IS407 and IS1416) that possess the ability to activate transcription and hence influence gene expression. A second aim was to map the genomic insertion sites of one of the active insertion sequences (IS407) to establish putative links between insertion site and downstream gene activation. The resulting data revealed that all three insertion sequences were present in one-third of the 66 isolates tested. The three insertion sequences were prevalent across the nine B. cepacia complex species, although IS402 was absent from the 16 Burkholderia anthina strains tested and IS407 was absent from all 10 Burkholderia pyrrocinia strains. IS407 copies from six strains (two Burkholderia cenocepacia strains and one strain each of Burkholderia multivorans, Burkholderia stabilis, Burkholderia vietnamiensis and B. anthina) were mapped to the genome using hemi-nested inverse
Bacteria of the Burkholderia cepacia complex (Bcc) are pathogens of humans, plants, and animals. Burkholderia cenocepacia is one of the most common Bcc species infecting cystic fibrosis (CF) patients and its carriage is associated with poor prognosis. In this study, we characterized a general O-link …
A plate assay to detect bacterial lipase (EC 3.1.1.3) in a medium containing trioleoylglycerol and the fluorescent dye rhodamine B is presented. Substrate hydrolysis causes the formation of orange fluorescent halos around bacterial colonies visible upon UV irradiation. The logarithm of lipase activity from cell-free culture supernatants is linearly correlated with the diameter of halos, thereby allowing quantitation of lipase activities ranging from 1 to 30 nkat. ...
Looking for online definition of BCAM or what BCAM stands for? BCAM is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Reagents, Tools and Custom Services for molecular biology, specializing in the fields of Nano-Antibody development (nAb), Cellular Reprogramming (iPSC), Genome Editing, Fluorescent Proteins, RNAi, Viral Packaging and Protein expression.
CEPI: Part of the Problem or the Solution?. Certainly, dont tell a New World Order organization called the Coalition for Epidemic Preparedness Innovations (CEPI) about this coronavirus cure. CEPI is handing out research grants to develop a vaccine. This is free money to pharmaceutical and biotech companies and actually the whole reason for the conjured-up epidemic, to develop a vaccine with public money.. CEPI is a private/public coalition headquartered in Norway with $760-billion of funding by various countries, including the Wellcome Trust and the Bill & Melinda Gates Foundation.. Note: Burroughs Wellcome & Co. (gift to 650 newspapermen at the First Imperial Press Conference, 1909, bankrolled by Harry Wellcome, whose Empire Press Union, 1909 newspapermen created British MI6, MI5 and CG&CS renamed GCHQ in 1946 with the founding of Five Eyes (UK, US, CA, NZ, and AU Commonwealth secret intelligence sharing)-wait, the U.S. is sovereign, right? Wrong. More at ...
The construction sector is very important for the European economy, generating almost 10% of EU GDP and providing 20 million jobs. However it has been affected by a number of adverse factors, with building and infrastructure work falling by 17% between January 2008 and April 2012 across the EU-27. Amongst the adverse factors are the bursting of the housing bubbles in several EU countries and the contraction of the market for credit. As well as addressing these problems it is seen as important to ensure the sustainability of the sector and to meet the challenge of the introduction of nearly zero energy buildings as announced in the recast of the Energy Performance of Buildings Directive ...
"Burkholderia cenocepacia". NCBI Taxonomy Browser. 95486. Type strain of Burkholderia cenocepacia at BacDive - the Bacterial ... because they were first identified in Burkholderia cenocepacia. Burkholderia cenocepacia has the ability to swim and swarm ... Burkholderia cenocepacia is one of over twenty bacteria in the Burkholderia cepacia complex (Bcc), and among these species, it ... sRNAs identified in Burkholderia cenocepacia KC-0 were upregulated under iron depletion and oxidative stress.Burkholderia ...
Sass AM, De Waele S, Daled S, Devreese B, Deforce D, Van Nieuwerburgh F, Coenye T (October 2019). "Burkholderia cenocepacia ... Sass A, Kiekens S, Coenye T (November 2017). "Identification of small RNAs abundant in Burkholderia cenocepacia biofilms reveal ... Characterization of the secondary structures of 4 tsRNAs in Burkholderia cenocepacia suggests they form double hairpin ... Typically, each species of Burkholderia has 3-5 homologous tsRNAs. Experiments with four species of the Burkholderia lineage ...
Loutet SA, Valvano MA (October 2010). "A decade of Burkholderia cenocepacia virulence determinant research". Infect. Immun. 78 ... Burkholderia cepacia is also found in marine environment (marine sponge) and some strain of Burkholderia cepacia can tolerate ... Burkholderia cepacia complex in the NCBI Taxonomy Browser Type strain of Burkholderia cepacia complex at BacDive, the Bacterial ... Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, ...
... is produced by Burkholderia cenocepacia under iron-deficient conditions. B. cenocepacia is known to ... "The ornibactin biosynthesis and transport genes of Burkholderia cenocepacia are regulated by an extracytoplasmic function sigma ... "Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia (formerly ... Coenye T, Vandamme P, Govan JR, LiPuma JJ (October 2001). "Taxonomy and identification of the Burkholderia cepacia complex". ...
Examples of these opportunistic pathogens include Pseudomonas aeruginosa, Burkholderia cenocepacia, and Mycobacterium avium. ...
... and motility in Burkholderia cenocepacia". Journal of Bacteriology. 193 (23): 6712-23. doi:10.1128/JB.05979-11. PMC 3232912. ... "Elucidation of the Burkholderia cenocepacia hopanoid biosynthesis pathway uncovers functions for conserved proteins in hopanoid ...
"Genomics Reveals a Unique Clone of Burkholderia cenocepacia Harboring an Actively Excising Novel Genomic Island". Frontiers in ...
... biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic ...
"The Novel Cis-Encoded Small RNA h2cR Is a Negative Regulator of hfq2 in Burkholderia cenocepacia". PLOS ONE. 7 (10): e47896. ... In molecular biology, the h2cR sRNA is a small RNA produced by species of the bacterial genus Burkholderia. It binds to the ...
As first discovered in plants, diffusible signal factors (DSFs) have been found in bacteria such as Burkholderia cenocepacia ...
... such as the chronic Pseudomonas aeruginosa and Burkholderia cenocepacia infections characteristic of cystic fibrosis. Other ...
... archaea and a number of pathogenic bacteria including Burkholderia cenocepacia, Neisseria gonorrhoeae and Acinetobacter ... "A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence". ...
Some species, such as Pseudomonas aeruginosa, Burkholderia cenocepacia, and Mycobacterium avium, are opportunistic pathogens ...
... cultures were identified as Burkholderia cenocepacia strain VIMP01 (JQ867371), Burkholderia gladioli strain VIMP02 (JQ811557), ... Burkholderia gladioli strain VIMP03 (JQ867372) and Burkholderia species strain VIMP04 (JQ867373)6]. Additionally, phosphate (P ... Isolates were strains of Burkholderia named as VIMP01, VIMP02, VIMP03 and VIMP04. VIMP (Vasantdada Sugar Institute Isolate by ...
By age 15, bacteria had colonized Smith's lungs, including a form of Burkholderia cenocepacia which mutated over a decade of ...
... alpina Burkholderia ambifaria Burkholderia anthina Burkholderia arboris Burkholderia cenocepacia Burkholderia ... Burkholderia dolosa Burkholderia gladioli Burkholderia glumae Burkholderia humptydooensis Burkholderia lata Burkholderia latens ... Burkholderia mallei Burkholderia metallica Burkholderia multivorans Burkholderia oklahomensis Burkholderia plantarii ... Burkholderia pseudomallei Burkholderia pseudomultivorans Burkholderia puraquae Burkholderia pyrrocinia Burkholderia seminalis ...
... ambifaria Burkholderia cenocepacia Burkholderia multivorans Burkholderia vietnamiensis Burkholderia xenovorans Burkholderia sp ... Bacillus pumilus Pathema-Burkholderia Burkholderia mallei Burkholderia pseudomallei Burkholderia thailandensis Burkholderia ... Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens, and Entamoeba histolytica) involved in new and re- ... Burkholderia phages Pseudomonas aeruginosa Ralstonia solanacearum Pathema-Clostridium Clostridium acetobutylicum Clostridium ...
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...
The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...
The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...
... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...
Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...
Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...
Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...
... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...
At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...
The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...
Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, Burkholderia cepacia genomovars I and III. J Clin ... Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound ... Burkholderia cenocepacia sp. nov.-a new twist to an old story. Res Microbiol. 2003;154:91-6. DOIPubMedGoogle Scholar ... Burkholderia cenocepacia Vaginal Infection in Patient with Smoldering Myeloma and Chronic Hepatitis C Andrea Petrucca*†, Paola ...
CCUG48434T - Burkholderia cenocepacia, Deposit Date: 2003-11-17
Burkholderia cenocepacia causes Cepacia syndrome, a fatal pneumonia that affects Cystic Fibrosis patients. Aromatic degradation ... B. cenocepacia has two paralogous copies of PaaK, the phenylacetyl-CoA ligase, which produces PA-CoA, the inducer of the ... has been linked to virulence in B. cenocepacia by insertional mutagenesis of genes involved in phenylacetic acid catabolism. ...
The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. Bioinformatics 2008 Dec 1;24(23):2803 ... If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than ... Burkholderia cenocepacia J2315, BCAM0387 (poxB) .list-group { margin-bottom: 5px; width: 150px; text-align: left; } Cytoplasmic ...
Sequential burkholderia cenocepacia isolates from siblings with cystic fibrosis show increased lung cell attachment ... Cullen L, OConnor A, Drevinek P, Schaffer K, McClean S. Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic ...
The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. Bioinformatics 2008 Dec 1;24(23):2803 ... If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than ...
The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia *Saira Ahmad ...
The Small RNA ncS35 Regulates Growth in Burkholderia cenocepacia J2315. * Authors: Kiekens S, Sass A, Van Nieuwerburgh F, ... Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. However, antibiotic ... Title: Identification of Burkholderia cenocepacia essential genes using TraDISPublication Date: 2016-11-04. bioproject: ... Comparative analysis of the Burkholderia cenocepacia K56-2 essential genome reveals cell envelope functions that are uniquely ...
All but two of these identified genes were located on chromosome 1 of Burkholderia cenocepacia. Although many of the 649 core ... cenocepacia. CONCLUSIONS/SIGNIFICANCE: We report on the identification of essential genes using a novel bioinformatics strategy ... such as members of the Burkholderia cepacia complex. METHODOLOGY/PRINCIPAL FINDINGS: We hypothesize that essential genes may be ... High confidence prediction of essential genes in Burkholderia cenocepacia. Juhas M., Stark M., von Mering C., Lumjiaktase P., ...
Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, Burkholderia cepacia genomovars I and III. J Clin ... Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound ... Burkholderia cenocepacia sp. nov.-a new twist to an old story. Res Microbiol. 2003;154:91-6. DOIPubMedGoogle Scholar ... Burkholderia cenocepacia Vaginal Infection in Patient with Smoldering Myeloma and Chronic Hepatitis C On This Page ...
Burkholderia cenocepacia lectin D - protein of two faces? MALINOVSKÁ Lenka VARROT Annabelle IMBERTY Anne WIMMEROVÁ Michaela ... Lectins from Burkholderia cenocepacia - potential virulence factors MALINOVSKÁ Lenka ŠULÁK Ondřej IMBERTY Anne WIMMEROVÁ ...
Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease. J Immunol. 2005 Mar 15. 174(6):3562-9. [ ...
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug ...
CRYSTAL STRUCTURE OF PUTATIVE GLUCOSE 1-DEHYDROGENASE FROM BURKHOLDERIA CENOCEPACIA IN COMPLEX WITH NADP AND A POTENTIAL ... CRYSTAL STRUCTURE OF PUTATIVE GLUCOSE 1-DEHYDROGENASE FROM BURKHOLDERIA CENOCEPACIA IN COMPLEX WITH NADP AND A POTENTIAL ... CRYSTAL STRUCTURE OF PUTATIVE GLUCOSE 1-DEHYDROGENASE FROM BURKHOLDERIA CENOCEPACIA IN COMPLEX WITH NADP AND A POTENTIAL ... BURKHOLDERIA CENOCEPACIA J2315. --. 7V0H_B P80725 BCAL1425. ESCHERICHIA COLI BL21(DE3). BURKHOLDERIA CENOCEPACIA J2315. --. ...
Burkholderia cepcia complex (B. cepacia, B. cenocepacia, at least 8 other genomospecies) ...
has been reported to interact with Burkholderia cenocepacia in patients with CF [79], and with Mycobacterium tuberculosis in ...
Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia. J. Immunol. 2012, 188, 3469-3477. [Google ...
Burkholderia cenocepacia: A0A3N9F8Q0, B1JYC0; Burkholderia cenocepacia PC184: A2VRQ0; Burkholderia cenocepacia: A0K5W6, Q1BXT4 ... A0A228QFT5 (A0A228QFT5_9BURK) Burkholderia sp HI2761. Elongation factor P UniProtKBInterProInteractive Modelling. 185 aa; ...
... and Burkholderia cenocepacia (Aubert et al., 2016). A genome-level survey revealed that more than 25% of genome-sequenced Gram- ... 2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol. Microbiol. 64, 1466-1485. doi: 10.1111/j ... 2016). A Burkholderia Type VI effector deamidates Rho GTPases to activate the Pyrin Inflammasome and trigger inflammation. Cell ... such as Burkholderia species (Schell et al., 2007; Shalom et al., 2007), Edwardsiella tarda (Zheng and Leung, 2007), ...
Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence Heleen Van Acker (UGent) , Andrea Sass ( ... antifungal agents, bacterial persistence, biofilm, burkholderia, burkholderia-cepacia, candida-albicans biofilms, cells, cystic ...
Purpose. Burkholderia cenocepacia is among the most common members of the Burkholderia cepacia complex (Bcc) isolated from ... Insights into the genome diversity and virulence of two clinical isolates of Burkholderia cenocepacia Tamara Salloum, Elie ... In this study, we aim to highlight the genome diversity of two clinical isolates of B. cenocepacia through comparative genome ... Conclusion. This study mapped existing genetic variations in B. cenocepacia associated with notorious outcomes in CF patients, ...
Triggered by an increase in Burkholderia cepacia complex (BCC) bacteremias and the detection of BCC in unopened packages of ... We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I ... An outbreak of Burkholderia cenocepacia associated with contaminated chlorhexidine solutions prepared in the hospital. Am J ... A napkin-associated outbreak of Burkholderia cenocepacia bacteraemia in haemodialysis patients. J Hosp Infect. 2006;64(1):56-62 ...
My daughter Mallory would battle that superbug, Burkholderia cenocepacia, for 13 years. At some point, she also acquired a ...
Asghar AH, Shastri S, Dave E, Wowk I, Agnoli K, Cook AM & Thomas MS (2011) The pobA gene of Burkholderia cenocepacia encodes a ... Asghar AH, Shastri S, Dave E, Wowk I, Agnoli K, Cook AM & Thomas MS (2011) The pobA gene of Burkholderia cenocepacia encodes a ... Spiewak HL, Shastri S, Zhang L, Schwager S, Eberl L, Vergunst AC & Thomas MS (2019) Burkholderia cenocepacia utilizes a type VI ... Spiewak HL, Shastri S, Zhang L, Schwager S, Eberl L, Vergunst AC & Thomas MS (2019) Burkholderia cenocepacia utilizes a type VI ...
Burkholderia cenocepacia (strain AU 1054). Q1BHG9. 0 transm. helices 389 amino acids ...
The structure of CyaY from Burkholderia cenocepacia. 4lk8. 4LK8. 4lp1. 4LP1. 5kz5. 5KZ5. ...
The main focus of her research is experimental evolution of the bacteria Pseudomonas aeruginosa and Burkholderia cenocepacia. ...
Title: SARS-CoV2 infection in CF patient colonized by Burkholderia cenocepacia Authors C Olcese, R Casciaro, D Pirlo, C Debbia ...
Lung transplantation can be considered in patients infected with Burkholderia cenocepacia, Burkholderia gladioli, and multi- ...
  • The consensus phylogenetic tree of recA DNA sequences of Burkholderia cepacia complex strains, representative of each genomovar, and of the B. cenocepacia isolate (GenBank accession no. (cdc.gov)
  • Speert DP , Henry DA , Vandamme P , Corey M , Mahenthiralingam E . Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada. (cdc.gov)
  • Agodi A , Mahenthiralingam E , Bachitta M , Giannino V , Sciacca A , Stefani S . Burkholderia cepacia complex infection in Italian patients with cystic fibrosis: prevalence, epidemiology, and genomovar status. (cdc.gov)
  • Spilker T, Gill GH, Campbell PW, Liu L, Mahenthiralingam E. Disproportionate distribuition of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis. (cdc.gov)
  • Taxonomy and identification of the Burkholderia cepacia complex. (cdc.gov)
  • Nzula S , Vandamme P , Govan JR . Influence of taxonomic status on the in vitro antimicrobial susceptibility of the Burkholderia cepacia complex. (cdc.gov)
  • Phenotypic methods for determining genomovar status of the Burkholderia cepacia complex. (cdc.gov)
  • nov. and Burkholderia pyrrocinia , two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools. (cdc.gov)
  • Vermis K , Coenye T , Mahenthiralingam E , Nelis HJ , Vandamme P . Evaluation of species-specific recA -based PCR tests for genomovar level identification within the Burkholderia cepacia complex. (cdc.gov)
  • CDC of a cluster of eight invasive infections with Burkholderia bacterial bioburden (7.0 x 106-5.8 x 107 colony-forming stabilis , a bacterium in the Burkholderia cepacia complex units/mL) in bottles from two of these lots. (cdc.gov)
  • New antimicrobial therapies are desperately needed to treat multidrug-resistant pathogens, such as members of the Burkholderia cepacia complex. (ox.ac.uk)
  • To date, the genus Burkholderia comprises more than 30 species, including the Burkholderia cepacia complex, B. mallei , and B. pseudomallei ( 2 ). (cdc.gov)
  • Triggered by an increase in Burkholderia cepacia complex (BCC) bacteremias and the detection of BCC in unopened packages of washing gloves, an ad hoc national outbreak committee comprising representatives of a public health organisation, a regulatory agency, and an expert association convened and commissioned an outbreak investigation. (eurosurveillance.org)
  • BACKGROUND: Cepacia syndrome (CS) is an acute, necrotizing pneumonia with a high mortality rate, occurring in patients with cystic fibrosis (CF) infected with Burkholderia cepacia complex (BCC). (bvsalud.org)
  • The main focus of her research is experimental evolution of the bacteria Pseudomonas aeruginosa and Burkholderia cenocepacia . (ugent.be)
  • Burkholderia cepacia is an important opportunistic pathogen and causes pulmonary infection among individuals with cystic ffibrosis (CF). Burkholderia cepacia species are gram negative, rod shaped bacteria. (tmmedia.in)
  • All genomovars have been shown to cause infections, and B. cenocepacia and B. multivorans (genomovars III and II, respectively) are the genomovars most frequently isolated from CF patients ( 4 - 7 ). (cdc.gov)
  • The Small RNA ncS35 Regulates Growth in Burkholderia cenocepacia J2315. (edu.sa)
  • Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. (edu.sa)
  • Browse through the features of Burkholderia cenocepacia J2315 both graphically and through a table. (theseed.org)
  • Burkholderia cepacia (strain J2315 / LMG 16656). (inrae.fr)
  • Shalom G, Shaw JG & Thomas MS (2007) In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages. . (sheffield.ac.uk)
  • IMSEAR at SEARO: Immune responses of selected phagotopes from monoclonal antibodies of Burkholderia pseudomallei. (who.int)
  • Random peptide libraries displayed by bacteriophage T7 and M13 were employed to identify mimotopes from 4 monoclonal antibodies (MAbs) specific to Burkholderia pseudomallei. (who.int)
  • Insert DNA sequences of bound phages selected from four rounds of panning with each MAb revealed peptide sequences corresponding to B. pseudomallei K96243 hypothetical protein BPSL2046, hypothetical protein BpseP_02000035, B. pseudomallei K96243 hypothetical protein BPSS0784, B. pseudomallei 1710b hypothetical protein BURPS1710b_1104, and B. cenocepacia H12424 TonB-dependent siderophore receptor, all located at the outer membrane. (who.int)
  • The organism may lead to Burkholderia cepacia syndrome, a neutralizing pneumonia associated with fever that culminates in to a rapid and fatal clinical deterioration. (tmmedia.in)
  • Petrucca A , Cipriani P , Valenti P , Santapaola D , Cimmino C , Scoarughi GL , Molecular characterization of Burkholderia cepacia isolates from cystic fibrosis (CF) patients in an Italian CF center. (cdc.gov)
  • Burkholderia cenocepacia causes Cepacia syndrome, a fatal pneumonia that affects Cystic Fibrosis patients. (umanitoba.ca)
  • Cullen L, O'Connor A, Drevinek P, Schaffer K, McClean S. Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment. (tudublin.ie)
  • Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. (edu.sa)
  • Development of new treatments against the cystic fibrosis pathogen Burkholderia cenocepacia (G. Barbieri, S. Buroni). (unipv.eu)
  • Butt AT & Thomas MS (2017) Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species . (sheffield.ac.uk)
  • Shastri S, Spiewak HL, Sofoluwe A, Eidsvaag VA, Asghar AH, Pereira T, Bull EH, Butt AT & Thomas MS (2017) An efficient system for the generation of marked genetic mutants in members of the genus Burkholderia . (sheffield.ac.uk)
  • A 2017 outbreak of Burkholderia cenocepacia bacteremia across four hospitals in Australia infected 11 patients, primarily in intensive care units. (civco.com)
  • burch-a0k359 Burkholderia cenocepacia (strain HI2424) carboxylesterase, type b precursor , 9burk-a0a088uau9 Burkholderia cenocepacia. (inrae.fr)
  • We report a case of a vaginal infection caused by a strain of Burkholderia cenocepacia . (cdc.gov)
  • Draft genome sequence reveals co-occurrence of multiple antimicrobial resistance and plant probiotic traits in rice root endophytic strain Burkholderia sp. (ai4society.ca)
  • Aromatic degradation has been linked to virulence in B. cenocepacia by insertional mutagenesis of genes involved in phenylacetic acid catabolism. (umanitoba.ca)
  • The library of B. cenocepacia mutants can subsequently be subjected to various biologically related conditions to facilitate the discovery of genes involved in niche adaptation as well as pathogenicity and virulence. (edu.sa)
  • We report a case of vaginal infection, caused by B. cenocepacia, in a patient affected by smoldering myeloma, and chronic hepatitis C virus (HCV) infection. (cdc.gov)
  • Lung transplantation can be considered in patients infected with Burkholderia cenocepacia , Burkholderia gladioli , and multi-drug-resistant Mycobacterium abscessus if the infection is sufficiently treated preoperatively and there is a reasonable expectation for adequate control postoperatively. (medscape.com)
  • Burkholderia cepacia species may cause severe infection in individuals with cystic ffibrosis and immunosuppressed individuals. (tmmedia.in)
  • We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I medical device. (eurosurveillance.org)
  • In this study, we utilized TraDIS (Transposon Directed Insertion-site Sequencing) as a genome-wide screening tool to facilitate the identification of B. cenocepacia genes essential for its growth and viability. (edu.sa)
  • The saturated library allowed for the identification of 383 genes that were predicted to be essential in B. cenocepacia. (edu.sa)
  • We extended the application of TraDIS to identify conditionally essential genes required for in vitro growth and revealed an additional repertoire of 439 genes to be crucial for B. cenocepacia growth under nutrient-depleted conditions. (edu.sa)
  • Title: Identification of Burkholderia cenocepacia essential genes using TraDISPublication Date: 2016-11-04. (edu.sa)
  • High confidence prediction of essential genes in Burkholderia cenocepacia. (ox.ac.uk)
  • All but two of these identified genes were located on chromosome 1 of Burkholderia cenocepacia. (ox.ac.uk)
  • The essentiality of some of the core genes, including the known essential genes infB, gyrB, ubiB, and valS, as well as the so far uncharacterized genes BCAL1882, BCAL2769, BCAL3142 and BCAL3369 has been confirmed experimentally in B. cenocepacia. (ox.ac.uk)
  • Łochowska A, Iwanicka-Nowicka R, Zielak A, Modelewska A, Thomas MS & Hryniewicz MM (2011) Regulation of sulfur assimilation pathways in Burkholderia cenocepacia through control of genes by the SsuR transcription factor. . (sheffield.ac.uk)
  • Burkholderia cenocepacia lectin D - protein of two faces? (muni.cz)
  • The α-mannose-specific Burkholderia cenocepacia lectin A (BC2L-A) is used and shown to be able to retain C- and O-mannosylated peptides and might have superior properties over other mannose binding lectins for this purpose. (semanticscholar.org)
  • Burkholderia cepacia have the potential of overcoming antimicrobial preservative systems and antiseptics, and can grow in preserved aqueous oral liquids and topical products. (tmmedia.in)
  • Spiewak HL, Shastri S, Zhang L, Schwager S, Eberl L, Vergunst AC & Thomas MS (2019) Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition . (sheffield.ac.uk)
  • Sequential burkholderia cenocepacia isolates from siblings with cystic" by Louise Cullen, Andrew O'Connor et al. (tudublin.ie)
  • Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis. (edu.sa)
  • Mechanisms and regulation of antibiotic resistance in Burkholderia . (sheffield.ac.uk)
  • Coenye T , Vandamme P . Diversity and significance of Burkholderia species occupying diverse ecological niches. (cdc.gov)
  • Molecular epidemiology of Burkholderia species. (cdc.gov)
  • Comparative analysis of the Burkholderia cenocepacia K56-2 essential genome reveals cell envelope functions that are uniquely required for survival in species of the genus Burkholderia. (edu.sa)
  • The 2013 outbreak of Burkholderia cepacian complex (BCC) in Argentina affected 11 patients who had undergone an average of five ultrasound procedures or examinations in the neonatal, intensive care, and general medical units. (civco.com)
  • Only recA DNA sequences of reference B. cenocepacia strains (genomovar III, lineage IIIB) are included in the tree ( 4 , 13 ). (cdc.gov)
  • PC184) Putative uncharacterized protein , burcc-b1k5m2 Burkholderia cenocepacia, Burkholderia cepacia, alpha/beta hydrolase fold precursor , burch-a0axx4 Burkholderia cenocepacia, Burkholderia sp. (inrae.fr)
  • If you have used this database, please ensure that you acknowledge the Burkholderia Genome Database publication rather than just the website URL. (burkholderia.com)
  • The Burkholderia Genome Database: facilitating flexible queries and comparative analyses. (burkholderia.com)
  • Asghar AH, Shastri S, Dave E, Wowk I, Agnoli K, Cook AM & Thomas MS (2011) The pobA gene of Burkholderia cenocepacia encodes a group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin. . (sheffield.ac.uk)
  • Peptidase S10, serine carboxypeptidase , burca-q1bqx1 Burkholderia cenocepacia putative carboxypeptidase , burca-q1byn5 Burkholderia cenocepacia probable carboxypeptidase protein precursor , burca-q1bza9 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia sp. (inrae.fr)
  • This medium is recommended for detection of Burkholderia cepacia in pharmaceutical products. (tmmedia.in)
  • My daughter Mallory would battle that superbug, Burkholderia cenocepacia , for 13 years. (cdc.gov)