A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.
Items used to aid in ending a TOBACCO habit.
Compounds with BENZENE fused to AZEPINES.
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
Disorders related or resulting from use of amphetamines.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
The giving of drugs, chemicals, or other substances by mouth.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Pharmacy services accessed via electronic means.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
An activity in which the organism plunges into water. It includes scuba and bell diving. Diving as natural behavior of animals goes here, as well as diving in decompression experiments with humans or animals.
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
A standardized nomenclature for clinical drugs and drug delivery devices. It links its names to many of the drug vocabularies commonly used in pharmacy management.
Facilities for the preparation and dispensing of drugs.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A semisynthetic derivative of CODEINE.
A strong emotional feeling of displeasure aroused by being interfered with, injured or threatened.
Travel beyond the earth's atmosphere.
Condition in which no acceleration, whether due to gravity or any other force, can be detected by an observer within a system. It also means the absence of weight or the absence of the force of gravity acting on a body. Microgravity, gravitational force between 0 and 10 -6 g, is included here. (From NASA Thesaurus, 1988)
"Contrave Extended-Release- naltrexone hydrochloride and bupropion hydrochloride tablet, extended release". DailyMed. 26 April ... Naltrexone/bupropion is a combination medication used for weight loss in those that are either obese or overweight with some ... It combines low doses of bupropion and naltrexone. Both medications have individually shown some evidence of effectiveness in ... bupropion) which act as appetite suppressants are the main tools used for the treatment of obesity. Increase of the body's ...
2004). (bupropion hydrochloride) Tablets. Retrieved from https://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4065b1-20-tab11A ... Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI (2014). "Bupropion and Bupropion Analogs as Treatments for ... It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment, ... Also, transdermal delivery of bupropion and hydroxybupropion has been assessed finding bupropion to be the superior candidate ...
"DailyMed - BUPROPION HYDROCHLORIDE SR- bupropion hydrochloride tablet, film coated, extended release". Rosen LJ, Galili T, Kott ... "Bupropion hydrochloride". Drug Information Portal. U.S. National Library of Medicine. "Bupropion hydrobromide". Drug ... The clinically used bupropion is racemic, that is a mixture of two enantiomers: S-bupropion and R-bupropion. Although the ... "Drug Approval Package: Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets NDA #200063". U.S. ...
Prescribing information - Zyban (bupropion hydrochloride) sustained-release tablets, Glaxo Smith-Kline [dostęp 2010-01-06] . ... Bupropion R,R-. Hydroksy. bupropion S,S-. Hydroksy. bupropion Treo-. hydro. bupropion Erytro-. hydro. bupropion ... a b Prexaton Bupropion hydrochloride. Product information. W: TGA eBusiness Services [on-line]. Ascent Pharma Pty Ltd, 2 ... a b Bupropion hydrochloride tablet, film coated [Sandoz Inc]. W: DailyMed [on-line]. Sandoz, Inc., kwiecień 2013. [dostęp 22 ...
CS1 maint: discouraged parameter (link) "BUPROPION HYDROCHLORIDE tablet, film coated [Sandoz Inc]". DailyMed. Sandoz, Inc. ... CS1 maint: discouraged parameter (link) "Prexaton Bupropion hydrochloride PRODUCT INFORMATION". TGA eBusiness Services. Ascent ... List of side effects of bupropion. Headache Transient insomnia Abdominal pain Agitation Anxiety Asthenia Concentration ...
... bupropion hydrochloride) Wellvone (atovaquone) Zantac (ranitidine hydrochloride) Zeffix (lamivudine) Zejula (niraparib) Zinacef ... bupropion hydrochloride) Ambirix (for hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed)) Bexsero (for ... atovaquone and proguanil hydrochloride) Mepron (atovaquone) Mivacron (mivacurium chloride) Naramig (naratriptan hydrochloride) ... ropinirole hydrochloride) Respontin nebules (ipratropium bromide) Rythmol (propafenone hydrochloride) Rythmol SR (propafenone ...
BUPIVA CAINE HYDROCHLORIDE 72. BUPROPION 73. BUSPIRONE 74. BUTENAFINE HYDROCHLORIDE 75. BUTORPHANOL TARTRATE ...
"Tepanil (diethylpropion hydrochloride) tablet, extended release". Dailymed. National Institutes of Health. Caplan J (May 1963 ... Amfepramone is most closely chemically related to the antidepressant and smoking cessation aid bupropion (previously called ... 30 January 2013). "Diethylpropion Hydrochloride". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. ... "Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion". New Concepts of Psychostimulant ...
"DILTIAZEM HCL CD- diltiazem hydrochloride capsule, coated, extended release". DailyMed. 2017-02-01. Retrieved 2019-01-31. " ... "Inhibition of CYP2D6 activity by bupropion". Journal of Clinical Psychopharmacology. 25 (3): 226-9. doi:10.1097/01.jcp. ...
It is also marketed in combination with bupropion (naltrexone/bupropion) as Contrave, and was marketed with morphine (morphine/ ... Naltrexone is the generic name of the drug and its INN, USAN, BAN, DCF, and DCIT, while naltrexone hydrochloride is its USP and ... Naltrexone, as naltrexone/bupropion, is also used to treat obesity. Naltrexone has been best studied as a treatment for ... "Bupropion and naltrexone Uses, Side Effects & Warnings". Drugs.com. 8 June 2020. Retrieved 16 September 2020. "Morphine and ...
... also used in formulation with bupropion (naltrexone/bupropion) to treat obesity. Neurontin (gabapentin) - an anticonvulsant ... Desoxyn (methamphetamine hydrochloride) - used to treat attention deficit hyperactivity disorder and exogenous obesity. ... Contrave (naltrexone/bupropion) - a combination drug used for weight loss in those that are either obese or overweight with ... Wellbutrin SR or XL (bupropion) - an antidepressant of the norepinephrine-dopamine reuptake inhibitor class, used to treat ...
The NIH states that yohimbine hydrochloride has been shown in human studies to be possibly effective in the treatment of male ... Cyproheptadine, buspirone, stimulants such as amphetamines (including the antidepressant bupropion), nefazodone and yohimbine ...
Bupropion Scopolamine "Mecamylamine". drugs.com. Retrieved May 15, 2015. Bacher I, Wu B, Shytle DR, George TP (November 2009 ... "Determination That INVERSINE (Mecamylamine Hydrochloride) Tablet and Six Other Drug Products Were Not Withdrawn From Sale for ... Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non- ...
Cocaine Caffeine Methamphetamine hydrochloride - USFDA-approved for the treatment of obesity (as a short-term) under the brand ... Bupropion and naltrexone (combination) Cathine Clobenzorex Dexfenfluramine† (the D-enantiomer of fenfluramine; withdrawn for ...
... bupropion), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others. Many of these ... and forms a stable crystalline hydrochloride salt with a melting point of 217 °C. Substituted phenethylamines are a chemical ...
Renagel (Sevelamer) hydrochloride, for end stage renal disease. Renvela (Sevelamer) hydrochloride, for end stage renal disease ... Aplenzin (Bupropion), for depression and quit smoking. Captique (Dermal filler), for facial wrinkles. Carticel (Knee cartilage ...
LAs are weak bases and are usually formulated as the hydrochloride salt to render them water-soluble. At a pH equal to the ... One published case has been reported of successful treatment of refractory cardiac arrest in bupropion and lamotrigine overdose ... Examples include: Prilocaine hydrochloride and epinephrine (trade name Citanest Forte) Lidocaine, bupivacaine, and epinephrine ... "Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and ...
The drug has been used commercially as both the free base and the hydrochloride salt. The CAS Registry Number of the free base ... bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine". Cellular and Molecular Neurobiology. 19 (4): 427-42 ... Iprindole is the English and French generic name of the drug and its INN, USAN, BAN, and DCF, while iprindole hydrochloride is ... is 5560-72-5 and of the hydrochloride is 20432-64-8. Iprindole was developed by Wyeth and was marketed in 1967. ...
"DailyMed - ZOLOFT- sertraline hydrochloride tablet, film coated ZOLOFT- sertraline hydrochloride solution, concentrate". ... While nefazodone and bupropion do not have negative effects on sexual functioning, 67% of men on sertraline experienced ... "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Retrieved 8 January 2018. Hoskins M, ... Kavoussi RJ, Segraves RT, Hughes AR, Ascher JA, Johnston JA (December 1997). "Double-blind comparison of bupropion sustained ...
... hydrochloride has a melting point of 187−188 °C. In the outdated D/L system (+)-ephedrine is also referred to as D- ... Bupropion is an example of an antidepressant with an amphetamine-like structure similar to ephedrine, and it is an NDRI. Its ... It is most usually marketed as the hydrochloride or sulfate salt. Ephedrine exhibits optical isomerism and has two chiral ... "Ephedrine Hydrochloride 15mg Tablets Summary of Product Characteristics (SmPC)". emc. Retrieved 8 October 2020. "Ephedrine ...
... hydrochloride". Life Sciences. 23 (10): 1041-7. doi:10.1016/0024-3205(78)90664-1. PMID 713683. Fuller, RW; Perry, KW; Snoddy, ... A comparison of bupropion and the selective serotonin reuptake inhibitors". Biological Psychiatry. 60 (12): 1350-5. doi:10.1016 ... 2-octane hydrochloride, an inhibitor of uptake into dopamine and norepinephrine neurons". Neuropharmacology. 18 (5): 497-501. ... The discovery of fluoxetine hydrochloride (Prozac)". Nature Reviews Drug Discovery. 4 (9): 764-74. doi:10.1038/nrd1821. PMID ...
"venlafaxine-hydrochloride". The American Society of Health-System Pharmacists. Retrieved 3 April 2011. Grothe DR, Scheckner B, ... Venlafaxine appears to be more likely than the SSRIs and bupropion to induce mania and mixed episodes in bipolar patients. ... Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA (2006). "A double-blind comparison between bupropion XL ... It is usually sold as a mixture of the respective hydrochloride salts, (R/S)-1-[2-(dimethylamino)-1-(4 methoxyphenyl)ethyl] ...
The first generic ticlopidine hydrochloride was FDA approved in 1999. As of April 2015, Roche, Caraco, Sandoz, Par, Major, ... 2005). "Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation". Clin ... "A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. ...
"venlafaxine-hydrochloride". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.. ... Venlafaxine appears to be more likely than the SSRIs and bupropion to induce mania and mixed episodes in bipolar patients.[44] ... It is usually sold as a mixture of the respective hydrochloride salts, (R/S)-1-[2-(dimethylamino)-1-(4 methoxyphenyl)ethyl] ... "Venlafaxine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.. ...
"Buspirone Hydrochloride - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021. "BUSPIRONE HCL (buspirone hydrochloride ... Fava M (2007). "The combination of buspirone and bupropion in the treatment of depression". Psychotherapy and Psychosomatics. ... "BUSPAR® (buspirone hydrochloride) Tablets 5 mg & 10 mg PRODUCT INFORMATION" (PDF). TGA eBusiness Services. Aspen Pharma Pty Ltd ... Buspirone is the INN, BAN, DCF, and DCIT of buspirone, while buspirone hydrochloride is its USAN, BANM, and JAN. Buspirone was ...
"Strattera (atomoxetine hydrochloride)". TGA eBusiness Services. Eli Lilly Australia Pty. Limited. 21 August 2013. Archived from ... Concurrent treatment with a CYP2D6 inhibitor such as bupropion, fluoxetine, or paroxetine has been shown to increase plasma ... "Atomoxetine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from ... "Atomoxetine Hydrochloride - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021. British national formulary : BNF 76 ( ...
Generic Bupropion". 2012-12-06. Retrieved 2013-04-20. Healy, Melissa (2012-10-05). "Generic antidepressant pulled from U.S. ... For example, as of 2006, diltiazem hydrochloride had four equivalence groups, all using the same active ingredient, but ... complaints that generic versions of bupropion (Wellbutrin) were yielding unexpected effects. Subsequently, Impax Laboratories's ...
... hydrochloride has a melting point of 187−188 °C.[29]. In the outdated D/L system (+)-ephedrine is also referred to as ... Bupropion is an example of an antidepressant with an amphetamine-like structure similar to ephedrine, and it is an NDRI. Its ... It is most usually marketed as the hydrochloride or sulfate salt. ...
CYP2B6 (weakly) which metabolizes bupropion, cyclophosphamide, sertraline, tamoxifen, valproate, etc. By so doing, fluvoxamine ... 13 August 2013). Fluoxetine Hydrochloride. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved ...
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  • These highlights do not include all the information needed to use BUPROPION HYDROCHLORIDE TABLETS safely and effectively. (nih.gov)
  • See full prescribing information for BUPROPION HYDROCHLORIDE TABLETS. (nih.gov)
  • Monoamine Oxidase Inhibitors (MAOIs): Do not use MAOIs intended to treat psychiatric disorders with bupropion hydrochloride tablets or within 14 days of stopping treatment with bupropion hydrochloride tablets. (nih.gov)
  • Do not use bupropion hydrochloride tablets within 14 days of stopping an MAOI intended to treat psychiatric disorders. (nih.gov)
  • In addition, do not start bupropion hydrochloride tablets in a patient who is being treated with linezolid or intravenous methylene blue. (nih.gov)
  • Hypertension: Bupropion hydrochloride tablets can increase blood pressure. (nih.gov)
  • FORFIVO XL tablets are supplied for oral administration of 450 mg of bupropion hydrochloride as white to off-white extended-release tablets. (rxlist.com)
  • FORFIVO XL (bupropion hydrochloride extended-release tablets) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual ( DSM ). (rxlist.com)
  • Par announced the approval of bupropion hydrochloride extended-release tablets in the 300-mg strength. (drugstorenews.com)
  • In September 2012, the FDA asked companies making generic bupropion hydrochloride extended-release tablets to conduct studies in order to ensure that their versions were as effective as the branded version following reports of differences in efficacy between the branded drug and some generics. (drugstorenews.com)
  • HYDERABAD, Sept 5: Dr Reddy's Laboratories Limited on Thursday announced the launch of Bupropion Hydrochloride Extended-Release Tablets, USP (SR), a therapeutically equivalent generic version of Zyban? (dailyexcelsior.com)
  • Bupropion Hydrochloride) Extended-Release Tablets in the US market. (dailyexcelsior.com)
  • Although bupropion hydrochloride extended-release tablets (SR) is not indicated for treatment of depression, it contains the same active ingredient as the antidepressant medications WELLBUTRIN? (dailyexcelsior.com)
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  • Bupropion hydrochloride extended-release tablets (SR) are indicated for the treatment of major depressive disorder. (drugs-library.com)
  • The efficacy of bupropion hydrochloride extended-release tablets (SR) in maintaining an antidepressant response for up to 44 weeks following 8 weeks of acute treatment was demonstrated in a placebo-controlled trial (see CLINICAL PHARMACOLOGY). (drugs-library.com)
  • Nevertheless, the physician who elects to use bupropion hydrochloride extended-release tablets (SR) for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient. (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets (SR) are contraindicated in patients with a seizure disorder. (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets (SR) are contraindicated in patients treated with ZYBAN# (bupropion hydrochloride) Sustained-release Tablets, bupropion hydrochloride tablets, the immediate-release formulation, bupropion hydrochloride extended--release tablets (XL), the extended-release formulation, or any other medications that contain bupropion because the incidence of seizure is dose dependent. (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets (SR) are contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa because of a higher incidence of seizures noted in patients treated for bulimia with the immediate-release formulation of bupropion. (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets (SR) are contraindicated in patients undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines). (drugs-library.com)
  • The concurrent administration of bupropion hydrochloride extended-release tablets (SR) and a monoamine oxidase (MAO) inhibitor is contraindicated. (drugs-library.com)
  • At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion hydrochloride extended-release tablets (SR). (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets (SR) are contraindicated in patients who have shown an allergic response to bupropion or the other ingredients that make up bupropion hydrochloride extended-release tablets (SR). (drugs-library.com)
  • Bupropion hydrochloride extended-release tablets, USP (XL) are supplied for oral administration as 150 mg and 300 mg creamy- white to pale yellow extended-release tablets. (medlibrary.org)
  • In a study comparing 14-day dosing with bupropion hydrochloride extended-release tablets (XL), 300 mg once-daily to the immediate-release formulation of bupropion at 100 mg 3 times daily, equivalence was demonstrated for peak plasma concentration and area under the curve for bupropion and the three metabolites (hydroxybupropion, threohydrobupropion, and erythrohydrobupropion). (medlibrary.org)
  • Following single oral administration of bupropion hydrochloride extended-release tablets (XL) to healthy volunteers, the median time to peak plasma concentrations for bupropion was approximately 5 hours. (medlibrary.org)
  • The object of the present invention is to prevent (inhibit) the degradation of bupropion hydrochloric using stabilizer ingredients, thus allowing the preparation of pharmaceutical compositions such as instant and sustained release tablets and capsules which, from a cost of manufacture and processing standpoint, are much improved over those achievable in the past. (allindianpatents.com)
  • The maximum recommended daily dose of Mysimba is two tablets taken twice daily for a total dose of 32 mg naltrexone hydrochloride and 360 mg bupropion hydrochloride. (medicines.org.uk)
  • In patients with moderate or severe renal impairment, the maximum recommended daily dose for naltrexone/bupropion is two tablets (one tablet in the morning and one tablet in the evening) (see sections 4.4, 4.8 and 5.2). (medicines.org.uk)
  • The authors formulated bupropion hydrochloride tablets with various grades of methacrylic copolymers and analyzed the properties of the resulting dosage forms. (pharmtech.com)
  • The US Pharmacopeia 's ( USP ) monograph for extended-release bupropion hydrochloride tablets provides the in vitro release requirements, which are listed in Table I. (pharmtech.com)
  • This article describes the development of bupropion hydrochloride matrix tablets that match the USP specifications (6). (pharmtech.com)
  • The US Food and Drug Administration recommends that the ethanol-resistance test for extended-release bupropion hydrochloride tablets be conducted in 0.1 N HCl compared with 0.1 N HCl with varying ethanol concentrations ranging from 5% v/v to 40% v/v (7). (pharmtech.com)
  • In a correspondence issued December 2012, FDA requested all generic drug companies marketing a version of Bupropion HCl ER Tablets, 300 mg, to conduct a fasting bioequivalence (BE) study comparing their Bupropion HCl ER tablets, 300 mg, to GSK's WELLBUTRIN XL (Bupropion Hydrochloride Extended-release) Tablets, 300 mg. (thefreedictionary.com)
  • 2. What is Bupropion tablet Bupropion HCL tablets are supplied for oral administration as 150 mg 丨 Bupropion 150mg and 300 mg 丨 Bupropion 300mg creamy-white to pa le yellow extended-release tablets. (authorstream.com)
  • The initial dose of Wellbutrin SR (bupropion hydrochloride) is 150mg in the morning. (depression-guide.com)
  • At the end of acute treatment phase, the dose of bupropion XL will be reduced to 150mg/day for 1 week before discontinuation. (clinicaltrials.gov)
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  • Since Wellbutrin causes seizures in some people, do not take it if you have any type of seizure disorder or if you are taking another medication containing bupropion, such as Zyban, the quit smoking aid. (healthyplace.com)
  • Bupropion hydrobromide (Aplenzin) and bupropion hydrochloride (Budeprion SR, Budeprion XL, Buproban, Wellbutrin, Wellbutrin SR, and Wellbutrin XL) aren't approved for smoking cessation treatment, but bupropion hydrochloride under the names of Buproban and Zyban is approved for this use. (thefreedictionary.com)
  • Coverage for all Medicaid enrollees was reported for the nicotine patch (34 programs), bupropion or Zyban* (33 programs), nicotine gum (32 programs), varenicline (Chantix) (32 programs), nicotine nasal spray (28 programs), nicotine inhalers (27 programs), and nicotine lozenges (25 programs). (cdc.gov)
  • Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. (wikipedia.org)
  • In 1997, bupropion was approved as a smoking cessation aid under the brand name Zyban. (emedexpert.com)
  • Like Wellbutrin, Zyban is known generically as bupropion hydrochloride. (lawyersandsettlements.com)
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  • are taking ZYBAN® (used to help people stop smoking) or any other medicines that contain bupropion hydrochloride. (silverpharmacy.com)
  • 3. Other name of Bupropion HCL powder Bupropion hydrochloride/Bupropion HCL is marketed under the followin g names: Wellbutrin Wellbutrin SR Wellbutrin XL Zyban bupropion hydrochloride 4. (authorstream.com)
  • Bupropion (Zyban) is used to help people stop smoking. (planetdrugsdirect.com)
  • A controlled-release tablet formulation containing the hydrochloride salt of the aminoketone bupropion, with antidepressant activity and for potential use in promoting smoking cessation, improving sexual desire, and improving cancer-related fatigue. (cancer.gov)
  • Each tablet contains the labeled amount of bupropion hydrochloride and the inactive ingredients: carnauba wax, cysteine hydrochloride, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, and titanium dioxide and is printed with edible black ink. (rxlist.com)
  • Bupropion is an extended-release plain creamy white colored tablet which contains bupropion hydrochloride equivalent to 150 mg of bupropion. (clinicaltrials.gov)
  • Bupropion hydrochloride is a known amtidepressant sold in instant release tablet form under the brand name WELLBUTRINR. (allindianpatents.com)
  • with the proviso that a sustained release tablet comprising (i) bupropion hydrochloride and hydroxypropyl methylcellulose, the amount of hydroxypropyl methylceliulose to the amount of bupropion hydrochloride being from 0.19 : 1 to 1.1 : 1, and (ii) glycine hydrochloride or cysteine hydrochloride, is excluded. (allindianpatents.com)
  • For example if the tablet initially contains lOOmg bupropion hydrochloride (labeled amount) at time of preparation, after one year storage at least 80mg of undegraded bupropion hydrochloride will remain in the tablet. (allindianpatents.com)
  • Each tablet contains 8 mg naltrexone hydrochloride, equivalent to 7.2 mg of naltrexone, and 90 mg bupropion hydrochloride, equivalent to 78 mg of bupropion. (medicines.org.uk)
  • To evaluate the effectiveness of Eudragit polymers in retarding the drug release and in resisting ethanol influence, the authors developed a 150-mg sustained-release bupropion hydrochloride matrix tablet with anionic, cationic, and neutral Eudragit polymers. (pharmtech.com)
  • In 1996, the FDA approved a sustained-release tablet of bupropion hydrochloride called Wellbutrin SR and, in 2003, approved an extended-release tablet known as Wellbutrin XL-all manufactured by GlaxoSmithKline. (lawyersandsettlements.com)
  • Each Bupropion HCL tablet contains t he labeled amount of bupropion hydrochloride and the inactive ingredi ents: ethylcellulose glyceryl behenate methacrylic acid copolymer disper sion polyvinyl alcohol polyethylene glycol povidone silicon dioxide an d triethyl citrate. (authorstream.com)
  • Buy Bupropion HCL powder: usesdosageside effects 丨AASraw www.aasraw.com aas15aasraw.com The insoluble shell of the extended-release tablet may remain intact dur ing gastrointestinal transit and is eliminated in the feces. (authorstream.com)
  • Bupropion comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth. (planetdrugsdirect.com)
  • CS1 maint: discouraged parameter (link) "BUPROPION HYDROCHLORIDE tablet, film coated [Sandoz Inc]". DailyMed. (wikipedia.org)
  • The efficacy of the sustained-release formulation of bupropion in the maintenance treatment of MDD was established in a long-term (up to 44 weeks), placebo-controlled trial in patients who had responded to bupropion in an 8-week study of acute treatment [see Clinical Studies ]. (rxlist.com)
  • Glaxo then developed a sustained-release (SR) version which releases bupropion hydrochloride at a slower rate. (emedexpert.com)
  • Research on using both varenicline and bupropion at the same time is also being done. (cancer.org)
  • In this respect, bupropion is as effective as nicotine replacement therapy but inferior to varenicline. (wikipedia.org)
  • Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. (aafp.org)
  • And one year after treatment, 14 percent of those smokers using varenicline remained free of cigarettes, compared to just 6 percent of the bupropion-treated and less than 5 percent of those given a placebo. (scientificamerican.com)
  • Bupropion and varenicline tartrate are 2 smoking-cessation aids that do not contain nicotine. (rochester.edu)
  • I'm now on Wellbutrin for over a month at 300 mg of Wellbutrin XL (generic Bupropion). (depressionforums.org)
  • Extended-release bupropion is marketed as Wellbutrin XL by GlaxoSmithKline. (thefreedictionary.com)
  • FORFIVO XL (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. (rxlist.com)
  • In China almost all existing antidepressants are available on the market, but bupropion XL has not yet been approved. (clinicaltrials.gov)
  • Bupropion hydrochloride is a medication primarily used as an antidepressant and smoking cessation aid.It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. (raw-hormonepowders.com)
  • The mechanism of action of bupropion is unknown, as is the case with other antidepressants. (medlibrary.org)
  • In contrast to many psychiatric drugs, including nearly all antidepressants, bupropion does not cause weight gain or sexual dysfunction. (drugsupdate.com)
  • Bupropion also improves depression in bipolar disorder, with the efficacy and risk of affective switch being similar to other antidepressants. (wikipedia.org)
  • Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. (wikipedia.org)
  • Bupropion treatment also is not associated with the sleepiness that may be produced by other antidepressants. (wikipedia.org)
  • 1977). The bupropion research endeavour led to the discovery of a molecule with a novel mechanism of action and a favorable side-effect profile that minimized the anticholinergic, sympathomimetic, and cardiac effects of many of the antidepressants that were currently in use. (emedexpert.com)
  • (byoo proe' pee on) For people taking bupropion (Wellbutrin) for depression: A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (planetdrugsdirect.com)
  • You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of condition. (planetdrugsdirect.com)
  • Bupropion is in a class of medications called antidepressants. (planetdrugsdirect.com)
  • Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. (wikipedia.org)
  • Pierwotnie określany jako amfebutamone , nazwę bupropion wprowadzono w 2000 roku [7] . (wikipedia.org)
  • Serious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
  • Dwoskin et al (2006) Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. (tocris.com)
  • taking bupropion for smoking cessation. (2medicalcare.com)
  • Initially researched and marketed as an antidepressant, bupropion was subsequently found to be effective as a smoking cessation aid. (drugsupdate.com)
  • A drug, C 13 H 18 ClNO, used in its hydrochloride form for the treatment of depression and as an aid in smoking cessation. (thefreedictionary.com)
  • Bupropion is a medication primarily used as an antidepressant and smoking cessation aid. (chemchart.com)
  • Prescribed as an aid for smoking cessation bupropion reduces the severity of craving for tobacco and withdrawal symptoms such as depressed mood, irritability, difficulty concentrating, and increased appetite. (wikipedia.org)
  • In children and adolescents, the use of bupropion for smoking cessation does not appear to offer any significant benefits. (wikipedia.org)
  • The hydrochloride is available as an aid to smoking cessation treatment. (nih.gov)
  • Bupropion was licensed as a pharmacotherapy for smoking cessation in the United Kingdom in 2000, and for the prevention of episodes of the seasonal affective disorder in the United States in 2006. (emedexpert.com)
  • You also shouldn't use it if you use other medicines that contain bupropion hydrochloride. (rochester.edu)
  • In many cases, a causal relations hip to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. (rxlist.com)
  • Generic Bupropion Hydrochloride simply acts on the Dopamine receptor and it inhibits the neurotransmission like serotonin and nor epinephrine as neurotransmitters are responsible to send the signal to cerebral brain for addiction of nicotine. (mypillshop.com)
  • Among the 33 programs that covered at least one combination therapy, the nicotine patch plus bupropion slow release (SR) was the one combination covered by all. (cdc.gov)
  • The 2008 Public Health Service guideline identifies four combination therapies (i.e., two tobacco-dependence medications taken simultaneously) as being effective in treating tobacco-dependence: 1) nicotine patch and nicotine gum, 2) nicotine patch and nicotine nasal spray, 3) nicotine patch and nicotine inhaler, and 4) nicotine patch and bupropion SR ( 3 ). (cdc.gov)
  • The most commonly covered combination of tobacco-dependence treatments among the Medicaid programs was the nicotine patch and bupropion SR (33 programs), followed by the nicotine patch and nicotine gum (21 programs), the nicotine patch and nicotine inhaler (21 programs), and the nicotine patch and nicotine nasal spray (19 programs). (cdc.gov)
  • Combining bupropion and nicotine replacement therapy does not improve the quitting rate. (wikipedia.org)
  • Bupropion eases withdrawal symptoms and the urge to smoke, but it does not contain nicotine. (rochester.edu)
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  • Naltrexone/bupropion should be used with caution in patients over 65 years of age and is not recommended in patients over 75 years of age (see sections 4.4, 4.8 and 5.2). (medicines.org.uk)
  • Naltrexone/bupropion is contraindicated in patients with end-stage renal failure (see section 4.3). (medicines.org.uk)
  • For individuals who are at elevated risk for renal impairment, in particular patients with diabetes or elderly individuals, estimated glomerular filtration rate (eGFR) should be assessed prior to initiating therapy with naltrexone/bupropion. (medicines.org.uk)
  • Naltrexone/bupropion is contraindicated in patients with severe hepatic impairment (see section 4.3). (medicines.org.uk)
  • Naltrexone/bupropion is not recommended in patients with moderate hepatic impairment (see sections 4.4 and 5.2). (medicines.org.uk)
  • The safety and efficacy of naltrexone/bupropion in children and adolescents below 18 have not yet been established. (medicines.org.uk)
  • Therefore, naltrexone/bupropion should not be used in children and adolescents below 18. (medicines.org.uk)
  • FORFIVO XL can be used in patients who are receiving 300 mg/day of another bupropion formulation for at least 2 weeks, and require a dosage of 450 mg/day. (rxlist.com)
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  • Taking more than the recommended dose of Bupropion will increase your risk of having a seizure. (depression-guide.com)
  • What to do if you take Missed Dose of Bupropion hci? (depression-guide.com)
  • Ten years earlier, she had taken an uncertain dose of bupropion for an unknown duration without incident. (aao.org)
  • Bupropion is used to treat depression, chemical imbalances, helps you kick certain drug habits, Bupropion is also used to help some to stop smoking. (depression-guide.com)
  • The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled trials of depressed inpatients and in one 6-week controlled trial of depressed outpatients whose diagnoses corresponded most closely to the Major Depression category of the APA Diagnostic and Statistical Manual (DSM) (see CLINICAL PHARMACOLOGY). (drugs-library.com)
  • A majority of controlled clinical trials support efficacy of bupropion for the treatment of depression. (wikipedia.org)
  • However, the overall quality of the evidence is low, with one meta-analysis, for example, finding small effect size of bupropion in depression and another - large effect size. (wikipedia.org)
  • Comparative head-to-head clinical trials indicate that bupropion is similar in efficacy against depression to fluoxetine, sertraline, paroxetine, and venlafaxine. (wikipedia.org)
  • Given over the fall and winter months, bupropion prevents development of depression in those who suffer from recurring seasonal affective disorder: 15% of participants on bupropion experienced a major depressive episode vs 27% of those on placebo. (wikipedia.org)
  • In some countries bupropion is approved only as a product for quitting smoking and not as a treatment of depression. (emedexpert.com)
  • Buy Bupropion HCL powder: usesdosageside effects 丨AASraw www.aasraw.com aas15aasraw.com Bupropion powder CAS No.31677-93-7 is an antidepressant originally a pproved by the U.S. Food and Drug Administration FDA in 1989 for th e treatment of depression. (authorstream.com)
  • Bupropion HCL powder is used to treat depression. (authorstream.com)
  • 8. Bupropion is a medicine used to treat depression, but it also helps ex-smokers cope with anxiety, cravings, and other withdrawal symptoms. (rochester.edu)
  • I. Measure the ability of two dose levels of bupropion hydrochloride (bupropion), 150 or 300 mg of extended release, to improve sexual desire more than a placebo at 9 weeks (8 weeks on the target dose) as measured by the desire subscale of the female sexual function index (FSFI). (clinicaltrials.gov)
  • I. Evaluate the side effects of 150 and 300 mg bupropion extended release and differentiate these side effects from those observed in the placebo arm. (clinicaltrials.gov)
  • ARM A: Patients receive bupropion hydrochloride orally (PO) once daily (QD) on days 1-63 and placebo PO QD on days 8-71. (clinicaltrials.gov)
  • Subject will receive bupropion in 3 dose levels along with escitalopram matching placebo to maintain the blind in acute treatment phase. (clinicaltrials.gov)
  • Both bupropion and placebo demonstrated linear declines on the HAM-D during phase I p 0. (thectrforpsychotherapy.com)
  • Overall, six months after the therapy, bupropion increases the likelihood of quitting smoking by approximately 1.6 fold as compared to placebo. (wikipedia.org)
  • 25 women received bupropion and 25 women were in placebo group. (emedexpert.com)
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  • Bupropion hydrochloride is an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD). (nih.gov)
  • The hydrochloride salt of an aminoketone antidepressant. (pallipedia.org)
  • Bupropion is a typical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist. (drugsupdate.com)
  • At dose level 2 (Week 1 to Week 4), bupropion XL dose will be increased to 300mg/day for further 3 weeks. (clinicaltrials.gov)
  • At dose level 3 (Week 4 to Week 8), bupropion XL dose will be maintained at 300mg/day. (clinicaltrials.gov)
  • The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. (rxlist.com)
  • Use another bupropion formulation for initial dose titration (referring to prescribing information of other bupropion products). (rxlist.com)
  • Degradation of the buproprion hydrochloride in the formulation is inhibited to the extent that the pharmaceutical formulation will maintain at least 80% of its initial buproprion potency after one year. (allindianpatents.com)
  • hydrochloride in the pharmaceutical formulation (composition) in solid form. (allindianpatents.com)
  • For example if a formulation contains lOOmg of bupropion hydrochloride it would preferably contain-about 2.7 to 27g of stabilizer. (allindianpatents.com)
  • Bupropion is a weak blocker of the neuronal uptake of serotonin, dopamine and norepinephrine and is a central nicotinic acetylcholine receptor antagonist. (cancer.gov)
  • Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin. (medlibrary.org)
  • Bupropion does not inhibit monoamine oxidase or the reuptake of serotonin. (thectrforpsychotherapy.com)
  • Bupropion is more effective than selective serotonin reuptake inhibitors (SSRIs) at improving symptoms of hypersomnia and fatigue in depressed patients. (wikipedia.org)
  • Bupropion hydrochloride increases the levels of the chemicals dopamine, serotonin, and norepinephrine in the brain. (cancer.gov)
  • Bilateral effusions have previously been reported with venlafaxine hydrochloride, a norepinephrine and serotonin reuptake inhibitor. (aao.org)
  • To avoid high peak concentrations of bupropion and/or its metabolites, do not exceed 200 mg in any single dose. (rxlist.com)
  • The wacky metabolism of Wellbutrin (bupropion hydrochloride), and the fact that it's one of the metabolites that works on norepinephrine tells me that you should wait until things settle down in your system first. (depression-guide.com)
  • Three metabolites are active: hydroxybupropion, which is formed via hydroxylation of the tert -butyl group of bupropion, and the amino-alcohol isomers threohydrobupropion and erythrohydrobupropion, which are formed via reduction of the carbonyl group. (medlibrary.org)
  • Three metabolites have been shown to be active: hydroxybupropion, which is formed via hydroxylation of the tert -butyl group of bupropion, and the amino-alcohol isomers threohydrobupropion and erythrohydrobupropion, which are formed via reduction of the carbonyl group. (rxdrugsinfo.com)
  • Behavioral and biochemical investigations of bupropion metabolites. (thectrforpsychotherapy.com)
  • This suggests that if bupropion use were causative, one of its major active metabolites, hydroxybupropion or theobupropion (both with half-lives similar to that of topiramate), may be responsible. (aao.org)
  • This suggests underreporting or the presence within their patient of a rare, private polymorphism that causes bupropion or one of its metabolites to become a particularly potent choroidal vasodilator. (aao.org)
  • Bupropion Hydrochloride with NDC 68788-7786 is a a human prescription drug product labeled by Preferred Pharmaceuticals Inc.. The generic name of Bupropion Hydrochloride is bupropion hydrochloride. (ndclist.com)
  • The study found that approximately 60% of patients with MDD resistant to fluoxetine experienced a full or partial response to bupropion. (emedexpert.com)
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  • Children younger than 18 years of age should not normally take bupropion, but in some cases, a doctor may decide that bupropion is the best medication to treat a child's condition. (planetdrugsdirect.com)
  • Following chronic dosing, the mean steady-state plasma concentration of bupropion was reached within 8 days. (medlibrary.org)
  • The mean elimination half-life (±SD) of bupropion after chronic dosing is 21 (±9) hours, and steady-state plasma concentrations of bupropion are reached within 8 days. (rxdrugsinfo.com)
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  • Pharmacology interaction of morphine and bupropion. (migente.com)
  • Caix is lack of county bupropion hydrochloride and pregnancy and kaiser family foundation. (zasss.info)
  • Bupropion pregnancy registry. (migente.com)
  • Bupropion use during pregnancy may be associated with increased odds of congenital heart defects. (wikipedia.org)
  • Observe patients attempting to quit smoking with bupropion for the occurrence of such symptoms and instruct them to discontinue bupropion and contact a healthcare provider if they experience such adverse events. (nih.gov)
  • However, some of these symptoms occurred in people who were taking bupropion and continued to smoke. (thectrforpsychotherapy.com)
  • As with any medication, you may experience some side effects, but with Bupropion, most side effects are mild to moderate, and tend to go away as you continue taking Bupropion. (depression-guide.com)
  • The authors question why more such cases have not been reported since bupropion is a common medication. (aao.org)
  • The efficacy of bupropion in the treatment of a major depressive episode was established in two 4- week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies ]. (rxlist.com)
  • This multi-centre study will follow a randomised, double-blind, parallel-group, active-controlled design and will evaluate the efficacy, safety and tolerability of bupropion extended-release (XL) (300 mg/day) compared with escitalopram (10-20 mg/day) in outpatients and inpatients with major depressive disorder (MDD). (clinicaltrials.gov)
  • Bupropion efficacy and tolerability was studied in overweight and obese adult women. (emedexpert.com)
  • There are thirty-eight drug master file entries for bupropion hydrochloride. (drugpatentwatch.com)
  • Although most patients recovered without sequelae, deaths associated with overdoses of bupropion alone have been reported in patients ingesting large doses of the drug. (medlibrary.org)
  • For the study described in this article, the authors selected bupropion hydrochloride as the model drug. (pharmtech.com)
  • Bupropion hydrochloride, a white crystalline material, is a Class I drug with high water solubility (312 mg/mL) and high alcohol solubility (193 mg/mL) (4). (pharmtech.com)
  • The drug also outperformed an antidepressant, bupropion hydrochloride, sometimes used as a quitting aid. (scientificamerican.com)
  • The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment. (rxlist.com)
  • Bupropion was patented by Burroughs-Wellcome (later Glaxo-Wellcome, and, as of 2000, GlaxoSmithKline) in 1974. (emedexpert.com)
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  • WELLBUTRIN SR (bupropion hydrochloride) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual ( DSM ). (rxlist.com)
  • The screening phase (phase I) will be lasting for 0-14 days, subjects will be randomised to bupropion XL or escitalopram in a 1:1 ratio for acute phase treatment phase (phase II) for 8 weeks. (clinicaltrials.gov)
  • Bupropion hydrochloride is also useful as an anticholesterol agent, in suppressing prolacttn secretion, in preventing functional impairment and drowsiness seen upon administration of benzodiazepine, in the treatment or minimal bruin dysfunction, tardive dyskinesia, impaired mental alertness upon ingestion of ethanol and psychosexual dysfunction. (allindianpatents.com)
  • The bupropion treatment course lasts for seven to twelve weeks, with the patient halting the use of tobacco about ten days into the course. (wikipedia.org)
  • It is unclear whether extending bupropion treatment helps to prevent relapse of smoking. (wikipedia.org)
  • For all patients taking bupropion: Your health care provider will want to see you often while you are taking bupropion, especially at the beginning of your treatment. (planetdrugsdirect.com)
  • The molecular mechanism of the antidepressant effect of bupropion is unknown. (pallipedia.org)
  • The neurochemical mechanism of the antidepressant effect of bupropion is not known. (rxdrugsinfo.com)
  • How does Bupropion HCL work 丨Wellbutrin mechanism of acti on How does Bupropion HCL work Bupropion HCL is an antidepressant m edication that affects chemicals within the brain that nerves use to send messages to each other. (authorstream.com)
  • Slemmer et al (2000) Bupropion is a nicotinic antagonist. (tocris.com)
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