An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.
Drugs that bind to and block the activation of ADRENERGIC BETA-3 RECEPTORS.
Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS.
Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
A beta-2 selective adrenergic antagonist. It is used primarily in animal and tissue experiments to characterize BETA-2 ANDRENERGIC RECEPTORS.
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
Drugs that selectively bind to and activate beta-adrenergic receptors.
A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
That phase of a muscle twitch during which a muscle returns to a resting position.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Contractile activity of the MYOCARDIUM.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)
A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)
The systematic study of the complete DNA sequences (GENOME) of organisms.
Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
Carrying out of specific physical routines or procedures by one who is trained or skilled in physical activity. Performance is influenced by a combination of physiological, psychological, and socio-cultural factors.
The geographic area of the Great Lakes in general and when the specific state or states are not indicated. It usually includes Illinois, Indiana, Michigan, Minnesota, New York, Ohio, Pennsylvania, and Wisconsin.
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
Technique for limiting use, activity, or movement by immobilizing or restraining animal by suspending from hindlimbs or tails. This immobilization is used to simulate some effects of reduced gravity and study weightlessness physiology.
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
A plant genus of the family RUTACEAE which is used in Chinese medicine (DRUGS, CHINESE HERBAL). Evodiamine and other quinazoline alkaloids (QUINAZOLINES) are obtained from the fruit of E. ruticarpa.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Simple amine found in the brain. It may be modulator of sympathetic functions. Its derivatives are adrenergic agonists and antagonists. It is also used in chemical industry.
An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.
Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.
A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

Beta 1-, beta 2- and atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta. (1/31)

beta-adrenoceptor-mediated relaxation was investigated in ring preparations of rat isolated thoracic aorta. Rings were pre-constricted with a sub-maximal concentration of noradrenaline (1 microM) and relaxant responses to cumulative concentrations of beta-adrenoceptor agonists obtained. The concentration-response curve (CRC) to isoprenaline was shifted to the right by propranolol (0.3 microM) with a steepening of the slope. Estimation of the magnitude of the shift from EC(50) values gave a pA(2) of 7.6. Selective beta(1)- and beta(2)-adrenoceptor antagonists, CGP 20712A (0.1 microM) and ICI 118551 (0.1 microM), respectively, produced 4 and 14 fold shifts of the isoprenaline CRC. Atypical beta-adrenoceptor agonists also produced concentration-dependent relaxation of aortic rings. The order of potency of the beta-adrenoceptor agonists was (-log EC(50)): isoprenaline (6. 25)>cyanopindolol (5.59)>isoprenaline+propranolol (5.11)>CGP 12177A (4.40)>ZD 2079 (4.24)>ZM 215001 (4.07)>BRL 37344 (3.89). Relaxation to CGP 12177A and ZM 215001 was unaffected by propranolol (0.3 microM). SR 59230A (+info)

The beta3-adrenoceptor-mediated relaxation induced by epinephrine in guinea pig taenia caecum. (2/31)

The mechanisms of the beta-adrenoceptor mediated relaxation induced by epinephrine in guinea pig taenia caecum were examined. The relaxant response to epinephrine was unaffected by propranolol (approximately 10(-5) M) or phentolamine (approximately 10(-5) M). The response to epinephrine was antagonized in a concentration dependent manner by bupranolol, and Schild plot of the data revealed the pA2 value of 5.87. Epinephrine significantly increased cyclic AMP level in this preparation. Bupranolol (10(-4) M) significantly decreased the cyclic AMP level that was elicited by epinephrine, whereas propranolol (10(-5) M) produced no effect. These results suggest that the relaxant response to epinephrine in the guinea pig taenai caecum is mainly mediated by beta3-adrenoceptors.  (+info)

Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. (3/31)

The properties of the beta1-/beta2-adrenoceptor partial agonist carteolol were investigated in atypical beta-adrenoceptors on the guinea pig gastric fundus. Carteolol induced concentration-dependent relaxation in this tissue (pD2 = 5.55, intrinsic activity = 0.94). However, a combination of the selective beta1-adrenoceptor antagonist atenolol (100 microM) and the selective beta2-adrenoceptor antagonist butoxamine (100 microM) produced only small rightward shifts in the concentration-response curves of carteolol in the gastric fundus (pD2 = 4.91, intrinsic activity = 0.94). In the presence of both atenolol (100 microM) and butoxamine (100 microM), the non-selective beta1-, beta2- and beta3-adrenoceptor antagonist (+/-)-bupranolol (10-100 microM) caused a concentration-dependent right-ward shift of the concentration-response curves for carteolol in the guinea pig gastric fundus. Schild plot analyses of the effects of (+/-)-bupranolol against carteolol gave the pA2 value of 5.29 and the Schild slope was not significantly different from unity. Furthermore, carteolol (10 microM) weakly but significantly antagonized the relaxant responses to catecholamines ((-)-isoprenaline, (-)-noradrenaline and (-)-adrenaline), a selective beta3-adrenoceptor agonist BRL37344 ((R*,R*)-(+/-)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxy-acet ic acid sodium salt) and a non-conventional partial beta3-adrenoceptor agonist (+/-)-CGP12177A ([4-[3-[(1,1dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2- one] hydrochloride) in the guinea pig gastric fundus. These results suggest that the partial agonistic effects of carteolol are mediated by atypical beta-adrenoceptors in the guinea pig gastric fundus.  (+info)

(+/-)-Pindolol acts as a partial agonist at atypical beta-adrenoceptors in the guinea pig duodenum. (4/31)

The agonistic and antagonistic effects of (+/-)-pindolol (1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol) were estimated to clarify whether (+/-)-pindolol acts as a partial agonist on atypical beta-adrenoceptors in the guinea pig duodenum. (+/-)-Pindolol induced concentration-dependent relaxation with a pD2 value of 5.10 +/- 0.03 and an intrinsic activity of 0.83 +/- 0.03. However, the relaxations to (+/-)-pindolol were not antagonized by the non-selective beta1- and beta2-adrenoceptor antagonist (+/-)-propranolol (1 microM). In the presence of (+/-)-propranolol (1 microM), the non-selective beta1-, beta2- and beta3-adrenoceptor antagonist (+/-)-bupranolol (30 microM) induced a rightward shift of the concentration-response curves for (+/-)-pindolol (apparent pA2 = 5.41 +/- 0.06). In the presence of (+/-)-propranolol, (+/-)-pindolol (10 microM) weakly but significantly antagonized the relaxant effects to catecholamines ((-)-isoprenaline, (-)-noradrenaline and (-)-adrenaline), a selective beta3-adrenoceptor agonist BRL37344 ((R*,R*)-(+/-)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl) amino]propyl]phenoxyacetic acid sodium salt) and a non-conventional partial beta3-adrenoceptor agonist (+/-)-CGP12177A([4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H -benzimidazol-2-one] hydrochloride). These results demonstrate that (+/-)-pindolol possesses both agonistic and antagonistic effects on atypical beta-adrenoceptors in the guinea pig duodenum.  (+info)

Further evidence that (+/-)-carteolol-induced relaxation is mediated by beta2-adrenoceptors but not by beta3-adrenoceptors in the guinea pig taenia caecum. (5/31)

The properties of the beta1- and beta2-adrenoceptor partial agonist (+/-)-carteolol were investigated against the beta2- and beta3-adrenoceptors of the taenia caecum of the guinea pig. (--)-Isoprenaline and (+/-)-carteolol induced concentration-dependent relaxation in this tissue. The non-selective beta1- and beta2-adrenoceptor antagonist (+/-)-propranolol (10-100 nM), the selective beta2-adrenoceptor antagonist ICI 118,551 (10-100 nM) and the non-selective beta1-, beta2- and beta3-adrenoceptor antagonist (+/-)-bupranolol (10-100nM), caused a concentration-dependent rightward shift of the concentration-response curves for (--)-isoprenaline and (+/-)-carteolol. Schild regression plot analyses carried out for (+/-)-propranolol against (--)-isoprenaline and (+/-)-carteolol gave pA2 values of 8.35 and 8.24, respectively. Schild plot analyses of ICI 118,551 against (--)-isoprenaline and (+/-)-carteolol gave pA2 values of 8.47 and 8.41, respectively. Schild plot analyses of (+/-)-bupranolol against (--)-isoprenaline and (+/-)-carteolol gave pA2 values of 8.47 and 8.53, respectively. Slopes of the Schild plots were not significantly different from unity. These results suggest that the relaxant effects of (+/-)-carteolol in the guinea pig taenia caecum are mediated by beta2-adrenoceptors but not by beta3-adrenoceptors.  (+info)

Transdermal absorption of bupranolol in rabbit skin in vitro and in vivo. (6/31)

This study was designed to clarify the percutaneous penetration of bupranolol (BP), a beta-adrenoceptor antagonist, through rabbit skin and to compare the in vitro penetration with the in vivo absorption. BP penetrated across the skin slowly in the absence of enhancers in vitro. Isopropyl myristate and N-methyl-2-pyrrolidone enhanced the in vitro penetration, with a 3.6 times higher flux compared with that without enhancers. However, in the in vivo percutaneous absorption, the maximal penetration was obtained with the formulation added dlimonene, with a 3.0 times higher area under the concentration-time curve (AUC) than that for the formulation without enhancers. The plasma levels of BP determined, however, were extremely lower than the theoretical plasma steady-state concentrations predicted. The plasma levels of BP after application of these formulations were maintained in the range of 7-22 ng/ml for 30 h, of which concentrations were above the therapeutically effective concentration (1.5-4 ng/ml). Therefore, the transdermal systems will offer an efficient drug delivery system for the treatment of angina pectoris and tachycardia.  (+info)

Structure-activity relationship studies of (+/-)-terbutaline and (+/-)-fenoterol on beta3-adrenoceptors in the guinea pig gastric fundus. (7/31)

(+/-)-Terbutaline and (+/-)-fenoterol are both arylethanolamine analogs that have tertbutyl and aryliso-propyl substituents respectively at the a position on the nitrogen of the ethanolamine side chain. In the present study, we have investigated the structure-activity relationships of (+/-)-terbutaline and (+/-)-fenoterol as beta3-adrenoceptor agonists in the guinea pig gastric fundus. (+/-)-Terbutaline and (+/-)-fenoterol induced concentration-dependent relaxation of the precontracted gastric fundus with pD2 values of 4.45+/-0.10 and 5.90+/-0.09, and intrinsic activities of 1.00+/-0.03 and 0.99+/-0.01 respectively. The combination of the selective beta1-adrenoceptor antagonist (+/-)-atenolol (100 microM), and the selective beta2-adrenoceptor antagonist (+/-)-butoxamine (100 microM), produced a 2 and 6 fold rightward shift of the concentration-response curves for (+/-)-terbutaline and (+/-)-fenoterol respectively, without depressing the maximal responses. The order of potency of these agonists was (pD2 value): (+/-)-fenoterol (5.09+/-0.10) > (+/-)-terbutaline (4.13+/-0.08). In the presence of (+/-)-atenolol and (+/-)-butoxamine, however, the non-selective beta1, beta2- and beta3-adrenoceptor antagonist (+/-)-bupranolol caused a concentration-dependent rightward shift of the concentration-response curves for (+/-)-terbutaline and (+/-)-fenoterol. Schild plot analyses of the effects of (+/-)-bupranolol against these agonists gave pA2 values of 6.21+/-0.07 ((+/-)-terbutaline) and 6.37+/-0.06 ((+/-)-fenoterol) respectively, and the slopes of the Schild plot were not significantly different from unity (p>0.05). These results suggest that the relaxant responses to (+/-)-terbutaline and (+/-)-fenoterol are mainly mediated through beta3-adrenoceptors in the guinea pig gastric fundus. The beta3-adrenoceptor agonist potencies of arylethanolamine analogs depend on the size of the end of the alkylamine side chain.  (+info)

Burst-like control of lipolysis by the sympathetic nervous system in vivo. (8/31)

Rapid oscillations of visceral lipolysis have been reported. To examine the putative role of the CNS in oscillatory lipolysis, we tested the effects of beta(3)-blockade on pulsatile release of FFAs. Arterial blood samples were drawn at 1-minute intervals for 120 minutes from fasted, conscious dogs (n = 7) during the infusion of saline or bupranolol (1.5 micro g/kg/min), a high-affinity beta(3)-blocker. FFA and glycerol time series were analyzed and deconvolution analysis was applied to estimate the rate of FFA release. During saline infusion FFAs and glycerol oscillated in phase at about eight pulses/hour. Deconvolution analysis showed bursts of lipolysis (nine pulses/hour) with time-dependent variation in burst frequency. Bupranolol completely removed rapid FFA and glycerol oscillations. Despite removal of lipolytic bursts, plasma FFAs (0.31 mM) and glycerol (0.06 mM) were not totally suppressed and deconvolution analysis revealed persistent non-oscillatory lipolysis (0.064 mM/min). These results show that lipolysis in the fasting state consists of an oscillatory component, which appears to be entirely dependent upon sympathetic innervation of the adipose tissue, and a non-oscillatory, constitutive component, which persists despite beta(3)-blockade. The extinction of lipid fuel bursts by beta(3)-blockade implies a role for the CNS in the maintenance of cyclic provision of lipid fuels.  (+info)

HPLC Application #18956: b-Blockers (Bupranolol) on Lux 5 µm Cellulose-2 by Chiral SFC. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0
Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol:http://www.drugbank.ca/drugs/DB00571.
Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.
5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid - chemical information, properties, structures, articles, patents and more chemical data.
Page 3-Images and discussion of techniques which fall outside the other categories or cover more than one... Please be descriptive in your titles!
Can Bulletproof Home be a good way to defend ur home w/o building high walls or stocking food in basement? Check Out Bulletproof Home Review.
Title:Non-Conventional Desulfurization of Fuels and Biofuels: A Review. VOLUME: 13 ISSUE: 2. Author(s):Debarpita Ghosal* and Sankhajit Pal. Affiliation:Department of Chemical Engineering, C.V. Raman College of Engineering, Bhubaneswar, Odisha- 752054, Department of Chemical Engineering, C.V. Raman College of Engineering, Bhubaneswar, Odisha- 752054. Keywords:Desulfurization, fuel, biofuel, non-conventional processes, aromatics, microfibrous material.. Abstract:Sulphur compounds in fuel cause major environmental pollution. Hence, the desulphurization of fuel has become a tremendous concern. Aside from the standard hydrodesulphurization method, many new processes have gained attention. Our present work discusses varied non-conventional desulphurization techniques likeaerobic desulphurization, adsorbent desulphurization, membrane desulphurization, extractive desulphurization, etc. These strategies in conjunction with their pros and cons are mentioned well.. ...
Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated by removing the agonist, or by adding the ETAR antagonist BQ123 or the NO donor sodium nitroprusside. It could be terminated by adding calcitonin-gene related peptide (CGRP), most likely because CGRP causes ET-1/ETAR dissociation. Here we investigated this phenomenon in human coronary microarteries (HCMA). We simultaneously verified the effects of CGRP in RMA and HCMA towards other vasoconstrictors, i.e., the α1- adrenoceptor agonist phenylephrine, the thromboxane A2 analog U46619 (9,11-dideoxy-11α,9α-epoxy-methano-prostaglandin F 2α) and KCl. Long-lasting contraction (remaining after washing away the agonist) was observed for ET-1 in RMA, but not HCMA. Constrictions to phenylephrine, U46619 or KCl did not last upon washing. When added on top of ET-1-initiated contraction in RMA, CGRP effectively counteracted vasoconstriction, i.e., it ...
You are viewing an interactive 3D depiction of the molecule 4-{(2r)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy}-1h-indole-2-carbonitrile (C29H29N4O2) from the PQR.
There are close to 28 million nurses around the world who comprise a global workforce that delivers about 90 percent of primary healthcare, including frontline response to the COVID-19 pandemic. Ensuring their optimal contribution and continued well-being amid the myriad consequences of COVID-19 will increase the potential for measurable and improved health outcomes.. ...
Learn about Carteolol Hydrochloride (Carteolol) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
|.. ۞ Refactoring a double negative to make it a single positive conditional if ( !item.isNotFound() )item.is found as Double-Negative Regulatory T Cells: non-conventional regulators signaling pathways influencing SLF and c-Kit-mediated survival and proliferation. The Isolation Kit is developed for the isolation of CD4-CD8-CD56-CD3+TCRα/β+ T cells from PBMCs in peripheral blood lymphocytes. To examine the…
Tan CK., Davies M.J, McCluskey DK., Munro IR., Nweke MC., Tracey MC., Szita N., Electromagnetic stirring in a microbioreactor with non-conventional chamber morphology and implementation of multiplexed mixing, Journal of Chemical Technology and Biotechnology (2015) 1927- ...
The main subject is the equilibrium and the evolution of 2D and 3D dry soap-like |br /|foams. A star-triangle equivalence is proved using geometrical methods and |br /|invariance by inversion transformations. This equivalence states that triangular bubbles can be freely exchanged with threefold stars without perturbing the overall equilibrium; a star is a set of three edges ending at a central vertex. Considering an equilibrated foam in contact with a solid, curved and smooth, surface and considering the trace of the films on the surface as a non-conventional 2D foam, the equilibrium equations are established for this 2D foam, generalising the standard case of flat Hele-Shaw cells. The invariance of the vertex equilibrium conditions by conformal transformations is proved. As an application, the configurations of foams in thin interstices between two non parallel plates is analysed in details. Normal incidence and Laplaces law lead to an approximate equation relating the plate profile to a conformal map
Absynth Biologics discovers and develops vaccines and antibodies to prevent and treat bacterial infections based on proprietary, non-conventional platform for identifying novel protein antigen that harness the immune system and that use a dual-action mechanism. ...
Professional guide for Carteolol (Ophthalmic). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
A comparative study of application of different non-conventional filters on electroencephalogram., Gauri Shanker Gupta, Maanvi Bhatnagar, Shikhar Kumar, Rakesh Kumar Sinha
3. Invest to get the best quality human resources. Finding and retaining skilled workers is a major challenge for companies operating in Africa. Securing a supply of the best local people, recruiting in the diaspora, transferring skills from other parts of your company and working hard to retain key staff will be an essential element of success, notes E&Y.. 4. Expand from strategic economic hubs and think about non-conventional market groupings. Some African countries are much more developed than others when it comes to infrastructure, financial services and the availability of skilled labour. Investors should consider setting up their base in these countries for expansion into the rest of the continent.. Expansion plans should also look at non-conventional regional market groupings such as urban corridors, cultural affinities and regional economic communities in order to build critical mass and drive higher returns more quickly, says the report. ...
Among five strengths of Propranolol HCl manufactured and marketed by Pliva, Inc., PLIVA 469 is found right in the middle of the row. It is 40mg (Plivas propranolol pills range from 10mg to 80mg). Pliva 469 is is a non-selective beta blocker mainly used to treat hypertension and various heart problems. Pliva makes a generic version of the medication which can otherwise be available under brand names Inderal and InnoPran XL. Pliva 469 pill is easily distinguished by its light green color ...
Among five strengths of Propranolol HCl manufactured and marketed by Pliva, Inc., PLIVA 469 is found right in the middle of the row. It is 40mg (Plivas propranolol pills range from 10mg to 80mg). Pliva 469 is is a non-selective beta blocker mainly used to treat hypertension and various heart problems. Pliva makes a generic version of the medication which can otherwise be available under brand names Inderal and InnoPran XL. Pliva 469 pill is easily distinguished by its light green color ...
Inderal La 20 MG Tablet is a popular non-selective beta blocker medicine that is used for the lowering of high blood pressure and relieving chest pain caused due to reduced blood flow to the heart. It is also used for treating complications associated with heart, blood vessels, and other organs.Know Inderal La 20 MG Tablet uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
Its unfair that you decided to single out for a reason Edwin Casimero. He is a staunch supporter of that school of thought according to which the causes of most of the ailments that befell us are linked with the defectuous way in which most of us nourish ourselves. Hence his plea for raw, fruitarianism etc. You could not have failed to notice that he is a staunch enemy of junk food. The truth is that most what Casimero claims makes sense... True, his is an intuitionist, non-conventional approach that spits in the face of the establishment. But sooner or later, most of his daring theories prove to be right. I am not sure that cancer is a fungus (as he claims), perhaps it is up to a certain point, yet according to a recent New Scientist article, Alzheimer is a form of diabetes caused by the flawed way we feed ourselves (well, at least most of us) too much sugar and carbs, gluten and bad quality highly processed saturated oils ...
Molecular Caging (MC) processed dosage forms for various sustained release formulations applicable to solid, liquid, gel, and for oral or parenteral administrations. Micro and nano particles/capsules and non-conventional delivery systems ...
Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular compo …
The Energy Statistics Database contains comprehensive energy statistics on the production, trade, conversion and final consumption of primary and secondary; conventional and non-conventional; and new and renewable sources of energy. The Energy Statistics dataset, covering the period from 1990 onwards, is available at UNdata. For data prior to 1990, please refer to http://unstats.un.org/unsd/energy/edbase.htm ...
Harnessing AWRI s yeast and bacterial research to shape next-gen Chardonnay Part 1: Wild and non-conventional yeast - Christopher Curtin, Jennifer Bellon, Eveline Bartowsky, Paul Henschke, Paul Chambers, Markus Herderich and Isak Pretorius ...
There are many alternative views on cancer treatment. This category is dedicated to non-conventional treatment of cancer and information on alternative methods of dealing with chemotherapy and radiation.
While our ability to accurately diagnose and treat allergic disease has benefited from scientific understanding of what happens during an allergic reaction, a number of tests and treatments have been promoted in the absence of any scientific rationale. Some non-conventional approaches to disease also claim that various disorders unrelated to allergy have an immune basis.…
Ourea style is designed for an everyday active and refined lifestyle, combining both classic and non-conventional elements in its character. Large and discreet, the Spei comes with an adjustable shoulder strap and sleek statement magnetic fastenings placed on the middle closure of the bag. The Ourea is inspired by the
DISCLAIMER: 1. This pie does not contain actual crack. 2. This picture does not do it justice.. A few weeks ago my friend Carly asked if I had ever tasted Crack Pie. Crack Pie? Huh? She then explained its some crazy addictive pie shed heard about, and that you can buy it online from Momofuku Milk Bar for $44. Yes, $44. As fate would have it, the LA Times ran an article about the pie the very next day, and included in the article was the recipe. I promised Carly I would make it. So when I got invited to a friends Oscar party, I figured hey, why not try out the Crack Pie? Since the recipe yields two pies, I had grand plans of tasting one pie then freezing the rest of it so Carly could try it, and bringing the other pie to the party. Of course, my oven had other plans and I burned the first pie beyond repair (totally my fault, I set the oven incorrectly). This meant I only had one pie to work with and I would be bringing something I had never tasted to the party. To make matters worse, I read ...
Now some of you may be here because you wanted to see me attempt to fold pie. If there is enough of a request for it, Ill see what I can do later. But...
Connexin. 43 (Cx43) is the predominant gap junction (GJ) protein in the mammalian ventricular myocardium. The precise spatial order of Cx43 GJ channels in the heart is thought vital for maintaining cardiac synchrony. Disruption or remodelng of this order is a hallmark of arrhythmic disease and has been reported in ischemic and diabetic hearts. Protein-protein interactions and modifications of the Carboxyl-terminus (CT) of CX43 are major determinants of GJ function, size, distribution and organization during normal development and disease processes. The extreme CT domain of CS43 interacts directly with the second PDZ domain of the MAGUK protein Zonula Occludens 1 (ZO-1). It has been reported that this interaction regulates phosphorylation of Cx43 and directs Cx43 GJ localization at the intercalated disk. Additionally, levels of this interaction are increased in the ischemic and dilated heart suggesting a role of Cx43 ZO-1 association in disease. Recent work from the Gourdie laboratory has ...
TY - JOUR. T1 - Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. AU - Pak, Boryeong. AU - Schmitt, Christopher E.. AU - Choi, Woosoung. AU - Kim, Jun Dae. AU - Han, Orjin. AU - Alsiö, Jessica. AU - Jung, Da Woon. AU - Williams, Darren R.. AU - Coppieters, Wouter. AU - Stainier, Didier Y.R.. AU - Jin, Suk Won. PY - 2020/11/23. Y1 - 2020/11/23. N2 - Endothelial cells appear to emerge from diverse progenitors. However, to which extent their developmental origin contributes to define their cellular and molecular characteristics remains largely unknown. Here, we report that a subset of endothelial cells that emerge from the tailbud possess unique molecular characteristics that set them apart from stereotypical lateral plate mesoderm (LPM)-derived endothelial cells. Lineage tracing shows that these tailbud-derived endothelial cells arise at mid-somitogenesis stages, and surprisingly do not require Npas4l or Etsrp function, indicating that ...
One unique example of RNA processing is non-conventional splicing of RNAs, which is an essential step during transfer RNA (tRNA) maturation. tRNAs are transcribed as precursor transcripts (pre-tRNA) and are subjected to multiple posttranscriptional processing events before they can fulfil their function. Intron-containing pre-tRNAs undergo non-conventional splicing-a cytosolic, enzyme-catalysed processing reaction. The splicing of pre-tRNAs occurs in two steps: The intron is first excised by a splicing endonuclease and the resulting tRNA exon halves are ligated by tRNA ligase to form a fully matured functional tRNA. Because eukaryotic tRNA introns disrupt the anticodon stem-loop structure, the removal of these introns is an essential process ...
Non Conventional Aquatint V:. Date: May 4, 2017. Temperature: 71 F. Humidity: moderate. Researchers: Claire Crews and Sam Guerin. How does Neutralizer sprayed onto aquatinted plate effect the aquatint medium?. For this experiment we sprayed aquatint medium to cover the entire plate (sprayed for 3 minutes at a distance of 18″ with the nozzle open 2 turns), then immediately sprayed an area with neutralizer at 6″ for 3 seconds. Neutralizer caused aquatint medium to move to edges of sprayed area and drip to bottom of plate, creating some stopped out areas and some stippled areas.. Even coverage of aquatint medium on plate:. ...
Tosin Onabanjo is a Research Fellow in Energy Systems at Cranfield University, UK. Her research is actively contributing to the development of the Nano-Membrane Toilet, a project funded by the Bill and Melinda Gates Foundation and designed for people lacking access to modern sanitation. Here, she shares how a microbe Saccharomyces cerevisiae, popularly known as bakers yeast, influenced her non-conventional multidisciplinary career path. Meet Tosin on her Soapbox on Saturday, 9th July in Milton Keynes, as she speaks on The Role of Microbiomes in the Energy Economy.. SS: How did you get to your current position?. TO: I have a non-conventional career path! I started out as a Microbiologist with the intention to become a medical doctor. I got fascinated by microbes and their applications, so I completed my Bachelors in Microbiology at Olabisi Onabanjo University, Nigeria and went on to get a Masters degree in Biotechnology at University of Hertfordshire, UK. Prior to my Masters degree, I ...
Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.[1] ...
Nadolol is a non-selective beta blocker used in the treatment of high blood pressure and chest pain. Additionally, it is often prescribed in the treatment of atrial fibrillation, migraine headaches, and complications of cirrhosis.
Carteolol - Get up-to-date information on Carteolol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Carteolol
It is no secret that over the past two months, Goldman has commenced a full endorsement of Nominal GDP targetting as a method to stimulate the economy, not to mention Wall Streets bonus pool, after Ben Bernanke completely ignored Hatzius advice to reduce the Interest on Overnight Excess Reserve rate as well as subsequent pleading for a start of MBS LSAP. Mathematics once again aside, and as we demonstrated, the math works out to an non-trivial incremental $10 trillion in debt through 2016 on top of what will be issued, to catch up with the GDP growth run rate and to eliminate the excess slack in the economy, the question is whether NGDP would achieve any tangible stimulus at all, or merely reduce the Feds ever smaller arsenal of non-conventional means to boost the economy by one more approach. The attached rhetorical Q&A just released by Goldman seeks to answer that and any other left over questions one may have on NGDP as a policy measure, and further puts out the inverse strawman argument that it
The point is that the practice of medicine, whether conventional or non-conventional is always dependent upon the context of the culture within which it is practiced. That means that each culture has criteria upon which it decides whether something is effective or not effective. And there are no 100 per cent reliable criteria to determine whether one particular treatment will benefit each individual who undertakes it. At the moment, the litmus test for medicine in the west, is a scientific trial. However these trials are unreliable. I have friend with MS who has been presribed a cocktail of drugs, all of which are useless. When researching the efficacy of these drugs I discovered none of them had been trialed by the drug companies on unhealthy frail individuals taking many other prescription drugs, the very people they would be presribed to. Instead, drug trials are aimed first of all, at very healthy people who take no drugs at all. The target population in these situations receives a drug ...
The Energy Statistics Database contains comprehensive energy statistics on the production, trade, conversion and final consumption of primary and secondary; conventional and non-conventional; and new and renewable sources of energy. The Energy Statistics dataset, covering the period from 1990 onwards, is available at UNdata. For data prior to 1990, please refer to http://unstats.un.org/unsd/energy/edbase.htm ...
She has carved a permanent place in the showbiz world by taking non-conventional route from portraying a hot-headed don in Fukrey...
Alternative fuel sources come in all shapes and sizes. But if you are confused about what they are, here is a short definition. Alternative fuels are non-conventional or advanced sources of fuel; substances that can be used as fuel sources that are not conventional.
Mazes are usually two-dimensional. I wanted to create a three-dimensional one, said the always non-conventional Danish architect Bjarke Ingels at the launch of his new BIG Maze at the National Building Museum (NBM) in Washington, D.C.read more. ...
Carteolol, one that of the oldest selective for serotonin reuptaking inhibitors, is therefore commonly been prescribed to patients with major glaucoma, open facial angle. In addition to dors and ctags investigations, members news of Congress have recently written letters to each defendant, requesting information conceming their sales slip of Carteolol a
Easy to read patient leaflet for Carteolol (Ophthalmic). Includes indications, proper use, special instructions, precautions, and possible side effects.
Debugging through IE 8, I found that if you change your path from url(/pie/ie-css3.htc); to url(../css/PIE.htc); it worked fine for me. Try that ...
In the United States, several companies are venturing into the field of algal biofuels. Algae have indisputable advantages as a biofuel feedstock. Of all the green fuel options, algae alone seem to possess the potential to provide renewable oil in quantities adequately large to substantially displace petroleum-based fuels, say experts. Large-scale production of algal biofuels is still 5-10 years away, say officials from Exxon Mobil, which is in partnership with Synthetic Genomics to produce algae-based biofuels.. Microscopic algae yield up to 100 times more oil per acre than soybeans and other common biodiesel feedstock, according to Ms. Mary Rosenthal, Executive Director of Algal Biomass Organization. Microalgae can be up to 80 per cent oil by dry weight, although that number is for wild strains that are slow growers, according to Dr. Margaret McCormick of the technology company Targeted Growth. Genetically engineered microalgae, such as those created by Targeted Growth, approach 35-45 per cent ...
GE Wind Energy, the United States, has developed a 3.6 MW offshore turbine, the largest prototype ever erected. Installed in Spain, this wind unit represents the most advanced technology yet available. Patented power electronics, variable speed rotor and specially designed offshore enhancements make this system cost-effective and highly reliable. It is easy to install and maintain in the remote, offshore environments. Based on GEs proven 1.5 MW wind turbine series, the 3.6 MW model was specifically configured for high wind speed sites. With an increased generator size, a rotor diameter of 104 m and a swept area of 8,495 m2, this version is ideal for offshore markets worldwide. It also includes GEs patented voltage control technology that facilitates grid integration by improving grid voltage stability and overall system reliability. The land-based 3.6 MW prototype has a hub height of 100 m and rated power output of 3,600 kW. The offshore variant will have a 75 m hub height since there is less ...
Non Conventional Aquatint III:. Date: May 4, 2017. Temperature: 71 F. Humidity: moderate. Researchers: Claire Crews and Sam Guerin. How does a moving stencil effect line quality and texture when sprayed with a consistent distance and aperture of spray nozzle?. In this experiment, we were interested to see the effects of moving a stencil in front of the plate while applying the spray medium in an effort to create stencil ghosts overlapping on the plate. Our stencil was made from BFK and was held 1/2″ away from plate while spraying. As I held the stencil, I gradually moved its position every 30 seconds while spraying from 12-18″ away. Spray nozzle was open 2 turns.. Spraying copper plate through stencil.. ...
An electro-active spectacle lens is disclosed. The disclosed lens includes a first lens optic. The disclosed lens also includes a first electro-active zone positioned in a cooperative relationship with the first lens optic. In certain embodiments, the electro-active lens includes a range finder positioned in a cooperative relationship with the electro-active lens.
The interest of the vehicle producers in fulfillment emission legislations without adopting after treatment systems is driving to the use of non-conventional energy sources for modern engines.A previous test campaign dealing with the use of blends of diesel and propane in a CI engine has pointed out
I read a really powerful and valuable book for parents this week called Hes Not Autistic, But... How We Pulled Our Son From the Mouth of the Abyss by Tenna Merchent, M.H. I was initially drawn to this book because 1. The authors son was on the autism spectrum like mine and 2. the author believes that vaccines caused or at the very least greatly exacerbated her sons condition just like I believe was the case with my son. The author shares her journey to heal her son in non-conventional and … [Read more...] ...
While patients of OCD in India and other parts of the world keep looking for the cure of the disorder, they come across many schools of thoughts and treatments. For some, the allopathic or the western approach helps in reducing the symptoms or providing relief, other treatments also claim to impact the same way with less or no side effects. This raises a question: Are non-conventional medicines and treatments equivalent or even better than the conventional methods of treatment? To find out the answer, on behalf of OCD FREE INDIA, I Gourav Kundu, exchanged a few words with various people from all around the world. Also, in this series, I will bring to you more such unbiased content in the future, interviewing the advocates of Eastern approach as well towards the treatment of OCD so that it becomes easy for the readers in making any decision.. Today we have Mr Bill Powers from the United States to share his opinion on medicines and other treatments that helped him in the recovery from Obsessive ...
Ajman University was founded in 1988 as a non-conventional private institution of higher education in the UAE and in the Arab world.
Cuddys mother, Arlene, is admitted to Princeton Plansboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional - and illegal - means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlenes personal life that she kept secret from Cuddy and her sister Lucinda. Meanwhile, Taubs ex-wife, Rachel, puts him in contact with her brother who hires Taub to work a job on the side in exchange for much-needed income, which winds up taking a physical and emotional toll on him. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading “by the book medical student Masters to reevaluate her responsibility to practice within a code of ethics and to follow her boss orders.. ...
Hong Kong (PRWEB) February 27, 2014 -- Any start-up with a business plan based on innovation, ethical trading, green technology or non-conventional business
kick in the pie hole - MedHelps kick in the pie hole Center for Information, Symptoms, Resources, Treatments and Tools for kick in the pie hole. Find kick in the pie hole information, treatments for kick in the pie hole and kick in the pie hole symptoms.
So you know how I mentioned Jamesons and my pie fail? Well, we turned that pie frown upside-down and created an overwhelming pie success. Jameson received
Read the So I have two cans of cherry pie filling . . . discussion from the Chowhound Home Cooking, Pies food community. Join the discussion today.
Are you interested in our DIY food gift sets for pie lovers foodie? With our make-your-own homemade Scotch pie kit you need look no further.
20 LECCIONES SOBRE PATOLOGIA DEL PIE VILADOT PDF - Libros de Segunda Mano - Ciencias, Manuales y Oficios - Medicina, Farmacia y Salud: 20 lecciones sobre patologia del pie antonio viladot voegeli, mayo, .

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