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BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceAnalgesia, Patient-ControlledMorphineBrachial PlexusLabor, ObstetricDose-Response Relationship, DrugProcaineInjections, EpiduralAmbulatory Surgical ProceduresPregnancyPrilocaineEpinephrineSpecific GravitySciatic NerveThoracotomyHernia, InguinalHydromorphoneHydrocodoneAlbuterolOxymorphoneAndrostadienesDrug InteractionsAnaphylaxisSpeech DisordersPostural Orthostatic Tachycardia SyndromeDizzinessNanospheresTremor
Bupivacaine: A widely used local anesthetic agent.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Analgesia, Epidural: The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Analgesia, Obstetrical: The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.Anesthesia, Epidural: Procedure in which an anesthetic is injected into the epidural space.Anesthesia, Obstetrical: A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Pain, Postoperative: Pain during the period after surgery.Anesthesia, Caudal: Epidural anesthesia administered via the sacral canal.Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Sufentanil: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)Anesthetics, Combined: The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Adjuvants, Anesthesia: Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)Injections, Spinal: Introduction of therapeutic agents into the spinal region using a needle and syringe.Cesarean Section: Extraction of the FETUS by means of abdominal HYSTEROTOMY.Carticaine: A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Analgesia: Methods of PAIN relief that may be used with or in place of ANALGESICS.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.Subarachnoid Space: The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.Analgesia, Patient-Controlled: Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Brachial Plexus: The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.Labor, Obstetric: The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).Injections, Epidural: The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.Ambulatory Surgical Procedures: Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Specific Gravity: The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Thoracotomy: Surgical incision into the chest wall.Hernia, Inguinal: An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.Hydrocodone: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Oxymorphone: An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Speech Disorders: Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Nanospheres: Spherical particles of nanometer dimensions.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers. (1/1144)

BACKGROUND: Intrathecal adjuncts often are used to enhance small-dose spinal bupivacaine for ambulatory anesthesia. Neostigmine is a novel spinal analgesic that could be a useful adjunct, but no data exist to assess the effects of neostigmine on small-dose bupivacaine spinal anesthesia. METHODS: Eighteen volunteers received two bupivacaine spinal anesthetics (7.5 mg) in a randomized, double-blinded, crossover design. Dextrose, 5% (1 ml), was added to one spinal infusion and 6.25, 12.5, or 50 microg neostigmine in dextrose, 5%, was added to the other spinal. Sensory block was assessed with pinprick; by the duration of tolerance to electric stimulation equivalent to surgical incision at the pubis, knee, and ankle; and by the duration of tolerance to thigh tourniquet. Motor block at the quadriceps was assessed with surface electromyography. Side effects (nausea, vomiting, pruritus, and sedation) were noted. Hemodynamic and respiratory parameters were recorded every 5 min. Dose-response relations were assessed with analysis of variance, paired t tests, or Spearman rank correlation. RESULTS: The addition of 50 microg neostigmine significantly increased the duration of sensory and motor block and the time until discharge criteria were achieved. The addition of neostigmine produced dose-dependent nausea (33-67%) and vomiting (17-50%). Neostigmine at these doses had no effect on hemodynamic or respiratory parameters. CONCLUSIONS: The addition of 50 microg neostigmine prolonged the duration of sensory and motor block. However, high incidences of side effects and delayed recovery from anesthesia with the addition of 6.25 to 50 microg neostigmine may limit the clinical use of these doses for outpatient spinal anesthesia.  (+info)

A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. (2/1144)

BACKGROUND: This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. METHODS: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 ml bupivacaine, 0.125%, plus 7.5 microg sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 microg sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. RESULTS: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/-15 min and lasted +/-90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P<0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. CONCLUSIONS: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade.  (+info)

Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles. (3/1144)

BACKGROUND: Although various local anesthetics can cause histologic damage to skeletal muscle when injected intramuscularly, bupivacaine appears to have an exceptionally high rate of myotoxicity. Research has suggested that an effect of bupivacaine on sarcoplasmic reticulum Ca2+ release is involved in its myotoxicity, but direct evidence is lacking. Furthermore, it is not known whether the toxicity depends on the unique chemical characteristics of bupivacaine and whether the toxicity is found only in skeletal muscle. METHODS: The authors studied the effects of bupivacaine and the similarly lipid-soluble local anesthetic, tetracaine, on the Ca2+ release channel-ryanodine receptor of sarcoplasmic reticulum in swine skeletal and cardiac muscle. [3H]Ryanodine binding was used to measure the activity of the Ca2+ release channel-ryanodine receptors in microsomes of both muscles. RESULTS: Bupivacaine enhanced (by two times at 5 mM) and inhibited (66% inhibition at 10 mM) [3H]ryanodine binding to skeletal muscle microsomes. In contrast, only inhibitory effects were observed with cardiac microsomes (about 3 mM for half-maximal inhibition). Tetracaine, which inhibits [3H]ryanodine binding to skeletal muscle microsomes, also inhibited [3H]ryanodine binding to cardiac muscle microsomes (half-maximal inhibition at 99 microM). CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic. Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics. The specific action of tetracaine to inhibit Ca2+ release channel-ryanodine receptor activity may in part counterbalance the nonspecific action, resulting in moderate myotoxicity.  (+info)

Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery. (4/1144)

We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or placebo. During the first 24 h after surgery, all patients received 4 ml h-1 of epidural bupivacaine 2.5 mg ml-1. From 24 to 48 h after operation, patients received epidural morphine 0.2 mg h-1 preceded by a bolus dose of 2 mg. In addition, patient-controlled analgesia (PCA) with i.v. morphine (2.5 mg, lockout time 15 min) was offered from 0 to 48 h after operation. Patients who received ketamine felt significantly more sedated at 0-24 h, but not at 24-48 h after operation, compared with patients who received placebo (P = 0.002 and P = 0.127, respectively). There were no significant differences in pain (VAS) at rest, during mobilization or cough, PCA morphine consumption, sensory block to pinprick, pressure pain detection threshold assessed with an algometer, touch and pain detection thresholds assessed with von Frey hairs, peak flow or side effects other than sedation. The power of detecting a reduction in VAS scores of 20 mm in our study was 80% at the 5% significance level. We conclude that we were unable to demonstrate an (additive) analgesic or opioid sparing effect of ketamine 10 mg h-1 i.v. combined with epidural bupivacaine at 0-24 h, or epidural morphine at 24-48 h after renal surgery.  (+info)

Neonatal outcome and mode of delivery after epidural analgesia for labour with ropivacaine and bupivacaine: a prospective meta-analysis. (5/1144)

In this prospective meta-analysis, we have evaluated the effect of epidural analgesia with ropivacaine for pain in labour on neonatal outcome and mode of delivery compared with bupivacaine. In six randomized, double-blind studies, 403 labouring women, primigravidae and multiparae, received epidural analgesia with ropivacaine or bupivacaine 2.5 mg ml-1. The drugs were administered as intermittent boluses in four studies and by continuous infusion in two. Apgar scores, neurological and adaptive capacity scores (NACS), degree of motor block and mode of delivery were recorded. The studies were designed prospectively to fit meta-analysis of the pooled results. Results showed similar pain relief and consumption of the two drugs. In the vaginally delivered neonates, NACS scores were approximately equal for both groups at 2 h, but at 24 h there were fewer infants with NACS less than 35 in the ropivacaine compared with the bupivacaine group (2.8% vs 7.6%; P < 0.05). Spontaneous vaginal deliveries occurred more frequently overall with ropivacaine than with bupivacaine (58% vs 49%; P < 0.05) and instrumental deliveries (forceps and vacuum extraction) less frequently (27% vs 40%; P < 0.01), while the frequency of Caesarean section was similar between groups. The intensity of motor block was lower with ropivacaine. There were no significant differences in adverse events.  (+info)

Incidence of bradycardia during recovery from spinal anaesthesia: influence of patient position. (6/1144)

We administered 0.5% plain bupivacaine 4 ml intrathecally (L2-3 or L3-4) in three groups of 20 patients, according to the position in which they were nursed in the post-anaesthesia care unit (PACU): supine horizontal, 30 degrees Trendelenburg or hammock position (trunk and legs 30 degrees elevated). Patients were observed until anaesthesia descended to less than S1. The incidence of severe bradycardia (heart rate < 50 beat min-1) in the PACU was significantly higher in patients in the Trendelenburg position (60%) than in the horizontal (20%, P < 0.01) or hammock (10%, P < 0.005) position. After 90 min, following admission to the PACU, only patients in the hammock position did not have severe bradycardia. In this late phase, the incidence of severe bradycardia in the Trendelenburg group was 35% (P < 0.005) and 10% in patients in the supine horizontal position. In four patients, severe bradycardia first occurred later than 90 min after admission to the PACU. The latest occurrence of severe bradycardia was recorded 320 min after admission to the PACU. We conclude that for recovery from spinal anaesthesia, the Trendelenburg position should not be used and the hammock position is preferred.  (+info)

Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. (7/1144)

We studied 32 patients undergoing bilateral symmetrical lower third molar surgery under general anaesthesia to determine if the combined effects of pre-emptive local anaesthetic block using 0.5% bupivacaine, together with i.v. tenoxicam and alfentanil had any benefits over postoperative administration. Patients acted as their own controls and were allocated randomly to have surgery start on one side, the second side always being the pre-emptive side. Difference in pain intensity between the two sides was determined using visual analogue scales completed by each individual at 6 h, and at 1, 3 and 6 days after operation. A long-form McGill pain questionnaire was also used to assess difference in pain intensity between the two sides on the morning after surgery. There was no significant difference in pain intensity at any time after surgery. Our findings indicate that the combined use of pre-emptive analgesia from 0.5% bupivacaine, tenoxicam and alfentanil did not reduce postoperative pain intensity in patients undergoing molar exodontia.  (+info)

Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. (8/1144)

BACKGROUND: The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to assess the relative analgesic potencies of epidural bupivacaine and ropivacaine by determining their respective minimum local analgesic concentrations. METHODS: Seventy-three parturients at < or = 7 cm cervical dilation who requested epidural analgesia were allocated to one of two groups in this double-blinded, randomized, prospective study. After a lumbar epidural catheter was placed, 20 ml of the test solution was given, either ropivacaine (n = 34) or bupivacaine (n = 39). The concentration of local anesthetic was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. Analgesic efficacy was assessed using 100-mm visual analog pain scores with < or = 10 mm within 30 min defined as effective. An effective result directed a 0.01% wt/vol decrement for the next patient. An ineffective result directed a 0.01% wt/vol increment. RESULTS: The minimum local analgesic concentration of ropivacaine was 0.111% wt/vol (95% confidence interval, 0.100-0.122), and the minimum local analgesic concentration of bupivacaine was 0.067% wt/vol (95% confidence interval, 0.052-0.082). Ropivacaine was significantly less potent than bupivacaine, with a potency ratio of 0.6 (95% confidence interval, 0.49-0.74). No difference in motor effects was observed. CONCLUSION: Ropivacaine was significantly less potent than bupivacaine for epidural analgesia in the first stage of labor.  (+info)

In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...
Background and Aims: The effect of local anesthetics on myometrial contractility during labor analgesia is debatable. We aimed to compare the effects of bupivacaine and levobupivacaine on rat uterine contractility in an in vivo setting. Methods: Electrical activities of 40 pregnant rat uteruses were recorded on electrohysterogram after dividing the rats into bupivacaine and levobupivacaine groups. Uterine contraction frequencies were recorded at each 5-min interval. The first 5-min recording was considered the control, which was immediately followed by intramyometrial administration of either bupivacaine or levobupivacaine. The recordings were continued for 30 min. The changes in frequencies at each time interval of the groups were compared with each other and the control recording. Results: The frequencies from both groups at each interval were lower than the control values, but not different between the groups. The frequencies of the bupivacaine group during the 5-10 min and 10-15 min ...
Comparative antibacterial activity of synthetic N,S-Heterocyclic derivatives, MgO nanoparticles, and glycine on zoonotic Vibrio...Comparative antibacterial activity of synthetic N,S-Heterocyclic derivatives, MgO nanoparticles, and glycine on zoonotic Vibrio...
Background: Vibrio fluvialis is an emerging zoonotic pathogen that its antibiotic-resistant strains are rapidly expanding. Discovering new antibacterial agents is one way to control it.Aims and Objectives: In this research, inhibitory potentials of glycine, magnesium oxide nanoparticles (NPs), and some synthesized thiazole, imidazolidine-2-thione, and tetrahydropyrimidine-2-thione derivatives were studied against V. 﫿uvialis in an in vitro manner.Materials and Methods: Thiazoles were prepared through Hantzsch reaction. Cyclic thioureas were synthesized from the reaction of diaminoalkanes and carbon disulfde. MgO NPs were created in 23.7-25.7nm by sol-gel processing. Antibacterial properties of all compounds as inhibition zone diameter, the minimum inhibitory concentration, and the minimum bactericidal concentration values were assessed through both disk diffusion and broth microdilution methods.Results: No inhibitory activity on V. 﫿uvialis was observed with MgO NPs and glycine. Among ...
Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...
Background: Spinal anaesthesia is the fastest and most reliable form of regional anaesthesia. Additions of intrathecaly adjuvants are useful for prolonging the spinal anaesthesia effects.Subjects and Methods:The Patients were divided in three groups; Group C (control group) = received 15 mg (3 ml) of hyperbaric bupivacaine intrathecaly. Group D = received 15 mg (3 ml) of hyperbaric bupivacaine plus 4μgDexmedetomidine intrathecally. Group F = received Hyperbaric Bupivacaine 15mg (3ml) plus 25μg fentanylintrathecally.Results: For the total duration of sensory block p- value is 0.000003, which is less than 0.05 (α) and is highly significant. From the above p - value and scheffe post hoc test we conclude that the Bupivacaine + Dexmedetomidine has prolonged duration of sensory block as compared to bupivacaine alone and in combination with fentanyl. For the motor block p- value is 0.000000 and is less than 0.05 (α). It is highly significant. For the demand of Analgesic p-value is 0.0000001 and is ...
Minimum analgesic concentration of bupivacaine after continuous epidural infusion following spinal anesthesia in the...Minimum analgesic concentration of bupivacaine after continuous epidural infusion following spinal anesthesia in the...
Case pain visual analog score persisted above 10 mm, patient was rejected and the same bupivacaines concentration was administered to the next patient.. Bupivacaines minimum analgesic concentration was calculated by Massey and Dixons formula 8.. Upper sensory block level and Bromage scores were compared between effective and ineffective concentrations by Mann-Whitney test. Significance level was established to 5%.. RESULTS. Demographics data of both samples are shown in table I.. Study I. Figure 1 shows the responses to different bupivacaine concentrations. Bupivacaines MAC-LA could not be calculated because data did not meet essential Massey and Dixon formulas requirements. There were 6 effective responses, 15 ineffective and 7 rejections. Mean bupivacaine concentration in this sample was 0.18% ±0.05%. Mean effective bupivacaine concentration was 0.19% ±0.07% and mean ineffective concentration was 0.18% ±0.055% (p,0.05). Median pain visual analog score (extremes) before bupivacaine ...
A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...
TY - JOUR. T1 - A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of pain following laparoscopy and dye. AU - Sripada, Sreebala. AU - Roy, S.. AU - Mathur, M.. AU - Hamilton, M. AU - Cranfield, K.. AU - Bhattacharya, Siladitya. PY - 2006. Y1 - 2006. N2 - The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. Women received either 15 ml of 0.9% saline (n=42) or 15 ml of 0.5% bupivacaine (n=43), which was instilled intraperitoneally. Pain and nausea scores were recorded on a visual analogue scale (VAS). Pain perception was no different in the bupivacaine group compared with the control group with median values of VAS at 2 hours (18, 19; P=0.8), 6 hours (21, 22; P=0.5), 12 hours (19, 25; P=0.8), 24 hours (27, 27; P=0.9) and 48 hours (21, 13; P=0.26). Women in the bupivacaine group were less ...
Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor - Full Text View - ClinicalTrials.govEffects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor - Full Text View - ClinicalTrials.gov
The aim of this study is to measure the effects of bupivacaine administered via epidural catheters on indices of motor blockade ascertained during the second stage of labor. This is a randomized, double-blind, controlled trial designed to address the primary research question: Does bupivacaine lengthen the second stage of labor? The secondary research question is: Is there other evidence of motor blockade attributable to bupivacaine during the second stage of labor?. The investigators know from prior studies that the length of the second stage in nulliparous women delivered at Parkland Hospital without epidural analgesia is 28 minutes. The investigators hypothesize in this now proposed study that epidural analgesia with bupivacaine will significantly increase this baseline from 28 minutes to 37 minutes or more (a 33% increase) thus implicating motor blockade. Baseline data for the Bromage and Breen scores during the second stage as well as the uterine contractility data are not available as ...
Continuous infusion bupivacaine via an elastomeric pumpContinuous infusion bupivacaine via an elastomeric pump
METHODS: A retrospective cohort study was conducted to evaluate patient outcomes following liposomal bupivacaine and elastomeric bupivacaine pump use from January through June 2013. The primary objective of the study was to evaluate 24-hour postoperative opioid use (in morphine equivalents).. RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included. Significant between-group differences were seen in American Society of Anesthesiologists physical status, patient-controlled analgesia use, postoperative nonopioid use, and surgical procedure. On univariate analysis, liposomal bupivacaine-in comparison with elastomeric bupivacaine pump -was associated with reduced median (interquartile range, IQR) 24-hour postoperative opioid use (33.0 mg morphine equivalents [IQR, 19.0-80.4 mg morphine equivalents] versus 70.4 mg morphine equivalents [IQR, 37.1-115.4 mg morphine equivalents], p , 0.001) and median 72-hour postoperative opioid use (61.3 mg morphine ...
Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine,...Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine,...
Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine, bupivacaine plus clonidine and bupivacaine plus dexmedetomidine in spinal anesthesia: prospective, comparative study
Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...
The aim of this study was to determine the onset and offset of antinociception after sciatic (ScN) and femoral (FN) nerve blocks. Six healthy adult cats (4.8±1.3years; 4.3±0.4 kg) were included in a randomised, crossover, blinded and controlled study. Following sedation with dexmedetomidine (25 µg/kg, intramuscular), each ScN and FN injection was performed using 0.1 ml/kg of saline (CONTROL), bupivacaine (0.46 per cent, 0.46 mg/kg; BUPI), bupivacaine and dexmedetomidine (1 µg/kg; BUPI-DEX) or bupivacaine and buprenorphine (2.5 µg/kg; BUPI-BUPRE). Atipamezole (250 µg/kg) was administered after injections. Paw withdrawal thresholds (PWT) and motor blockade were evaluated before sedation and up to 24 hours. The PWT were significantly increased at half an hour in CONTROL, from two to four hours in BUPI and BUPI-DEX when compared with baseline. Motor blockade was observed between one and three hours in treatments using bupivacaine. Ability to walk was significantly impaired in BUPI at half an ...
Bupivacaine Injection of Eye Muscles to Treat Strabismus - Full Text View - ClinicalTrials.govBupivacaine Injection of Eye Muscles to Treat Strabismus - Full Text View - ClinicalTrials.gov
Patients eligible for inclusion in the study will be age 8 to 95 years and have an eye deviation (strabismus) that is potentially subject to surgical correction.. The eye alignment will be measured. The eye muscles will be measured by MRI. The eye will be anesthetized by eye drops. One or more eye muscles will be injected with bupivacaine. Botox® will be injected into the antagonist muscle in some cases to increase the effect of the bupivacaine.. Data on the strabismus deviation, any side effects of the drug injection, and the eye muscles as measured by MRI, will be recorded at intervals after injection. These data will be compared with the like measurements taken before injection.. The primary outcome will be the eye alignment change at 180 days. A secondary outcome will be the change in muscle size, strength, or stiffness.. For large strabismus deviations not fully corrected by a first injection, a second injection can be made. Follow-up alignment and muscle measurements will be as for the ...
Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...
Introduction: Continuous research were undertaken in past to see the effect of anesthetic agent with adjuvant agents to increase their effect. The addition of adjuvant substances as clonidine, Dexmedetomidine, tramadol, midazolam, opioids, adenosine, to the local anesthetic drugs in TAPB and their efficiency have been studied. Hence the aim of the present study was to check the effect of Bupivacaine alone and Bupivicaine plus Dexamethasone in hernia block.Material & Methods: The total of 60 patients with age range from 30 to 60 years was included in the study. All the 60 patients were divided in to two groups, with 30 patients in each group. Group 1 consisted of 30 patients were administered with 20 ml of 0.5% bupivacaine in a TAP block performed at the same side of surgery to be performed. Group II consisted of 30 patients; were administered with 20 ml of 0.5% bupivicaine with 2 ml of dexamethasone in a TAP block performed at the same side of surgery.Results: In the present study, the duration of
Bupivacaine hydrochloride,monohydrate,usp - Alfa ChemistryBupivacaine hydrochloride,monohydrate,usp - Alfa Chemistry
Bupivacaine hydrochloride,monohydrate,usp/ACM73360540 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik
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Levobupivacaine - WikipediaLevobupivacaine - Wikipedia
Levobupivacaine (rINN) /liːvoʊbjuːˈpɪvəkeɪn/ is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine. Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time. Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children. Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA). Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur. Systemic exposure to ...
Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | CirculationStereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Determination of whether bupivacaine enantiomers block Na+ channels differently in the rested, activated, and inactivated channel states may result in a better understanding of their cardiodepressant effects. In the present study, both enantiomers of bupivacaine induced very limited tonic block measured as the reduction of INa amplitude during the first pulse after a long rest period. The amount of block measured from the reduction of peak current reflects both the rested-state block and the activated (open)-state interaction between the Na+ channel and the drug that develops during the depolarizing step before reaching peak current.18 Although tonic block is not necessarily an accurate measure of drug binding to rested Na+ channels, the observed low level indicates that both enantiomers must exhibit a low affinity for the rested state of the Na+ channel. Moreover, the interaction of bupivacaine enantiomers with the rested state of the Na+ channel was not stereoselective. Similar results were ...
Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin CellsEffect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
On the Convergence of Bio-, Information-, Enrivonmental-, Energy-, Space- and Nano-Technolgies: Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2
HPLC Application #17309: Bupivacaine on Lux Cellulose-2. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0
Journal of Anaesthesiology Clinical PharmacologyJournal of Anaesthesiology Clinical Pharmacology
Background : No drug, used as adjuvant to spinal bupivacaine, has yet been identified that specifically inhibits nociception without its associated side-effects. Aims : This prospective randomized double-blind study was conducted to evaluate the onset and duration of sensory and motor block as well as perioperative analgesia and adverse effects of dexmedetomidine and magnesium sulfate given intrathecally with 0.5% hyperbaric bupivacaine for spinal anesthesia. Materials and Methods : A total of 90 patients classified as American Society of Anesthesiologists status I and II scheduled for lower abdominal and lower limb procedures were prospectively studied. Patients were randomly allocated to receive intrathecally either 15 mg hyperbaric bupivacaine plus 0.1 ml (10 μg) dexmedetomidine (group D, n=30) or 15 mg hyperbaric bupivacaine plus 0.1 ml (50 mg) magnesium sulfate (group M, n=30) or 15 mg hyperbaric bupivacaine plus 0.1 ml saline (group C, n=30) as control. The onset time to reach peak ...
HTX-011 | Heron TherapeuticsHTX-011 | Heron Therapeutics
HTX-011, which utilizes our proprietary Biochronomer® drug delivery technology, is under investigation in Phase 3 clinical studies as a long-acting formulation of the local anesthetic bupivacaine in a fixed-dose combination with the anti-inflammatory meloxicam for the prevention of post-operative pain. By delivering sustained levels of both a potent anesthetic and an anti-inflammatory agent directly to the site of tissue injury, HTX-011 was designed to deliver superior pain relief while potentially reducing the need for systemically administered pain medications such as opioids, which carry the risks of harmful side effects, abuse, and addiction.. HTX-011 is the first long-acting anesthetic that is designed to address both post-operative pain and accompanying inflammation by combining the local anesthetic bupivacaine and the anti-inflammatory meloxicam in a single administration. Targeting both pain and inflammation has allowed HTX-011 to demonstrate an advantage over current standard of care ...
Cook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited StoreCook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited Store
0.5 Bupivacaine HCl with 1:200,000 epinephrine bitartrate. Specifically effective in lengthy dental procedures for which more than 90 minutes of pulpal anesthesia is necessary, or for the management of post-operative pain. Marcaine ® is the original bupivacaine in the dental world and is part of the complete line of Cook-Waite products the brand dental professionals have relied on for more than 60 years. Each box contains 50 x 1.7mL cartridges.. MSDS. Product Brochure. ...
Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...
Abstract of Paper: Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine in Caudal Analgesia after Lower Abdominal Surgery in Pediatrics , Author: Omar Mohey Eldin A. El-Maksoud MD, Ehab El -Shebat Afifi MD, Ahmed Mostafa A. El-Hamid MD and Ahmed A. Mosaad M.Sc , Year: 2012 , Faculty of Medicine, Benha University
Bupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiBupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Bupivacaine - Get up-to-date information on Bupivacaine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Bupivacaine
Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response...Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response...
Twenty patients undergoing elective cholecystectomy were prospectively randomised to receive either intrapleural (bolus 20 ml followed by 10 ml/h) or thoracic epidural (bolus 9 ml followed by 5 ml/h) bupivacaine 0.5% for 8 h postoperatively to assess the effect of these two techniques on pain, pulmonary function and the surgical stress response. As assessed by the visual analogue scale (VAS), both groups received good but not total pain relief. Both groups had a 50% reduction in forced expiratory volume (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEFR) after operation, and there was no observed effect on the stress response as measured by plasma glucose and cortisol. It is concluded that while both techniques provide good analgesia, the degree and extent of nerve blockade are not sufficient to affect the afferent neurogenic stimuli responsible for the observed effects on pulmonary function and the stress response ...
Episode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC PodcastEpisode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC Podcast
Great question. Here is Dr. Rayazs response:. You calculate the number of milligrams for both local anesthetics and then use the max dose that is the lower of the two local anesthetics. For example, if you give 100mg plain lidocaine without epinephrine (max dose of 4.5-5mg/kg depending on the source) and then intend on giving bupivacaine (max dose of 2.5mg/kg) for a 100kg patient, then you would do the following calculation:. Use the max dose for bupivacaine since it is the lower max dose of the two local anesthetics being used.. 2.5mg/kg x 100kg = 250mg. 250mg - 100mg = 150mg. That leaves 150mg of bupivacaine that can be used or about 60cc of 0.25% bupivacaine (150mg/2.5mg/kg) left over for a tap block.. For a 70kg patient:. 2.5mg/kg x 70kg = 175mg. 175mg - 100mg = 75mg. That leaves 75mg of bupivacaine for a tap block or 30cc of 0.25% bupivacaine (75mg/2.5mg/kg) or 15cc of 0.5% bupivacaine (75mg/5mg/kg). Its a bit more simple in practice than the math problems make it seem. In general, ...
FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...
Particulate matter found in solution, glass vial. The US Food and Drug Administration (FDA) has alerted health care professionals that Hospira, Inc (Lake Forest, IL) has announced a voluntary nationwide recall to the user level for 1 lot of 0.5% Marcaine (bupivacaine HCl injection, USP), 30 mL, single-dose vial - preservative free (NDC 0409-1560-29), lot 33-545-DD.. The recall is due to a confirmed customer report of particulate embedded in the glass vial as well as visible particulate in the solution. Hospira has attributed the embedded particulate to a suppliers glass defect, and is working with its supplier on implementing corrective and preventive actions.. According to Hospira, the recalled lot of Marcaine was distributed November 2013 through March 2014 to wholesalers/distributors, hospitals, and clinics across the United States.. If you have any inventory of the recalled product, you are advised to immediately stop use and quarantine it. Please also inform potential users of this product ...
Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: Inversion of postoperative pain relief efficacy. |...Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: Inversion of postoperative pain relief efficacy. |...
The number of ambulatory surgical procedures is growing and local anesthesia represents the technique of choice for outpatients undergoing minor surgery. The aim of this study was to verify whether differences exist in postoperative pain relief using equipotent doses of two long-acting local anesthetics, ropivacaine and levobupivacaine, in patients who underwent minor breast surgery. A series of 86 consecutive women (median age=55, range=39-75 years) with small (,2 cm in size) breast masses requiring surgical excision were prospectively enrolled in the study. Patients were randomly selected to receive 75 mg/ml ropivacaine (group A, 42 patients) or 5 mg/ml levobupivacaine (group B, 44 patient). For post-surgical measurement of pain intensity a visual analog scale (VAS) was used. The age of the patients (56.4±9.6 vs. 56.7 ±9.5 years; p=0.88) and operative time (38.4 ± vs. 39.8 ±5.0 min; p=0.16), did not differ significantly between the groups (A vs. B). Transient adverse effects were observed ...
Combined Spinal and General Anesthesia Attenuates Liver Metastasis by Preserving Th1/Th2 Cytokine Balance | Anesthesiology |...Combined Spinal and General Anesthesia Attenuates Liver Metastasis by Preserving Th1/Th2 Cytokine Balance | Anesthesiology |...
To evaluate the analgesic effect of spinal block and systemic morphine, we conducted a preliminary experiment. Analgesia was evaluated by the tail-flick (TF) test. The light beam from a projector bulb was focused on the middle portion of the tail to produce a spot of intense heat, and the TF latency was measured. The intensity of the thermal stimulus was adjusted so that the baseline TF latency was 1.0-2.5 s. A 10-s cutoff time was imposed to minimize tissue damage. In all experiments, the TF latency was determined three times for each mouse. Measurements were obtained before intervention and at 10, 30, 60, 120, 180, 240, 300, and 360 min after awaking from anesthesia. We tested five regimens of spinal block (25 μg bupivacaine alone, 25 μg bupivacaine plus 0.5 μg morphine, 25 μg bupivacaine plus 1.25 μg morphine, 25 μg bupivacaine plus 2.5 μg morphine, and 25 μg bupivacaine plus 5 μg morphine) and systemic injection of morphine (5 mg/kg intraperitoneally23). We also tested two control ...
A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...
Materials and Methods: This was a prospective study carried out in department of obstetrics and gynaecology in Rajah muthiah Medical College and Hospital from 2015-2017 after ethical clearance and written knowledgeable concent. A total of 100 parturients in both latent and active phase of labour were to receive an epidural injection of 12 ml of bupivacaine 0.125% as initial bolus dose. Same dose regimen was used as subsequent top-up dose on patients demand for pain relief. The duration and quality of analgesia, motor block, top-up doses required consumption of bupivacaine and feto-maternal outcome were observed ...
Brazilian Journal of Anesthesiology - Volume 59 / Issue 3Brazilian Journal of Anesthesiology - Volume 59 / Issue 3
Rev. Bras. Anestesiol., vol.59 n3, 261-272, 2009 Epidural block for cesarean section: a comparative study between 0.5% racemic Bupivacaine (S50-R50) and 0.5% enantiomeric excess Bupivacaine (S75-R25) associated with Sufentanil Angélica de Fátima de Assunção Braga; José Aristeu F. Frias; Franklin Sarmento da Silva Braga; Rosa Inês Costa Pereira; Mayla F Blumer; Marcia F Ferreira Scientific Article ...
Bupivacaine-induced myocardial depression and pulmonary edema:...Bupivacaine-induced myocardial depression and pulmonary edema:...
Bupivacaine-induced myocardial depression and pulmonary edema: a case report.: Central nervous system and cardiovascular toxicity are well-known side effects of
Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.
The pharmacokinetics of lidocaine and bupivacaine and tri-deuteromethyl-labelled lidocaine and bupivacaine were investigated in healthy volunteers. The deuterium-labelled and the unlabelled form of the drug to be investigated were simultaneously infu
Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
We aimed to investigate the efficacy of either plain or hyperbaric solutions of intrathecal bupivacaine and ropivacaine on maternal block characteristics, complications, side effects and neonatal parameters to find out which is superior in a single s
Bupivacaine implant - Innocoll - AdisInsightBupivacaine implant - Innocoll - AdisInsight
Innocoll (a subsidiary of Gurnet Point Capital) is developing a bupivacaine implant formulation for the treatment of postoperative pain. Bupivacaine is a local
Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...
Both PKA and PKC contribute to the activation of ERK in dorsal horn neurons. Kawasaki et al. 10 reported that there were additive effects of PKA and PKC on ERK activation, indicating that PKA and PKC are independent pathways to activate ERK in dorsal horn neurons. Forskolin, acting as a classic stimulator of adenylyl cyclase,34 can increase cAMP, activating PKA, and thus coupling to ERK through the Raf/Ras pathway. Although bupivacaine had no effects on pERK induced by nociceptor-associated GPCR agonists, which might also act through Ras/Raf, bupivacaine still reduced forskolin-induced pERK. Several studies have demonstrated, however, that forskolin has diverse sites of action including not only adenylyl cyclase, but also the glucose transporter and ligand- and voltage-gated ion channels.35 Forskolin modulates voltage-dependent K+conductance through cAMP-dependent and cAMP-independent mechanisms,35 inhibiting voltage-dependent K+channels in Helix neurons,36 nudibranch neurons,18 and PC12 cells37 ...
Bupivacaine & Adrenaline 0.5% - Drugs.comBupivacaine & Adrenaline 0.5% - Drugs.com
Bupivacaine & Adrenaline 0.5% is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bupivacaine & Adrenaline 0.5% is available on the Drugs.com website.
Update on the clinical utility and practical use of ropivacaine in Chi | DDDTUpdate on the clinical utility and practical use of ropivacaine in Chi | DDDT
Update on the clinical utility and practical use of ropivacaine in Chinese patients Man Li, Li Wan, Wei Mei, Yuke Tian Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China Abstract: We reviewed the Chinese and English literature for efficacy and tolerability data as well as pharmacological properties of ropivacaine in Chinese patients. Ropivacaine is a long-acting amide local anesthetic agent that elicits nerve block via reversible inhibition of sodium ion influx in nerve fibers. The available evidence in the literature on anesthesia practice indicates that ropivacaine produces equally surgical sensory block and postoperative and obstetrics analgesia with good maternal and fetal outcome to those of bupivacaine or levobupivacaine. It appears to be associated with comparable onset, quality, and duration of sensory block, but with a lower incidence or grade of motor block, compared to bupivacaine. The
June 21, 2020 - Food & Beverage HeraldJune 21, 2020 - Food & Beverage Herald
Levobupivacaine is a long-acting local anesthetic agent belonging to the amido amine group, it is basically an S-enantiomer of bupivacaine drug. It has become popular among anesthesiologists worldwide owing to its less cardiotoxicity and motor blockade. It was primarily developed due to the reported incidents of seizures and cardiac arrests experienced due to the use of intravenous injection of bupivacaine. Significant rise in surgeries performed and increasing demand for post-operative pain management drive the levobupivacaine market growth. Epidural anesthesia is currently representing the largest market share in the levobupivacaine market.…. Read More ...
Sabinet | Clinical trial: Bupivicaine hydrochloride in the treatment of sports injuriesSabinet | Clinical trial: Bupivicaine hydrochloride in the treatment of sports injuries
Bupivicaine hydrochloride is a long-acting local anaesthetic. Its use results in local anaesthesia lasting between 12-24 hours. The drug has been extensively used in thoracic and abdominal surgery and as caudal analgesia in obstetrics. It has also been used in nerve blocks.
Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLinkComparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLink
We conducted a retrospective study to determine whether bupivacaine or fentanyl is a better adjuvant to epidural morphine for postoperative analgesia using 108 patients. Following epidural lidocaine...
Buffered bupivacaine : Hulu ip addressBuffered bupivacaine : Hulu ip address
Sequence Analysis BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) BLAST Link (BLink) Conserved Domain Search Service (CD Search) Genome ProtMap Genome Workbench Influenza Virus Primer-BLAST ProSplign Splign All Sequence Analysis Resources.There is concern regarding neurotoxicity induced by the use of local anesthetics.The effect of pH buffering on reducing the pain associated with subcutaneous infiltration of bupivicaine.Lidocaine buffered with bicarb combination of lidocaine and bupivacaine,.The time taken to find the LA with epi with right concentration and working out the final combination dose is longer than the time to wait for the LA with epi (given straight) to work ...
Postoperative - ESRAPostoperative - ESRA
A study comparing thoracic epidural bupivacaine with and without opioid to a continuous paravertebral infusion of bupivacaine showed that analgesia on all postoperative days was superior in the thoracic epidural group receiving bupivacaine plus hydromorphone, but was similar in the epidural and continuous paravertebral groups receiving bupivacaine alone (Grider et al. 2012, n=75, LoE 1 ...
Anesthetics, Local - CatalogAnesthetics, Local - Catalog
Bupivacaine; Anekain; Bloqueina; Bupivacaina [INN-Spanish]; Bupivacaine HCL; Bupivacaine HCL KIT; Bupivacainum [INN-Latin]; Bupivacine HCL Preservative Free; Bupivan; Carbostesin; Chirocaine; DL-Bupivacaine; LAC-43; Marcaina; Marcaine; Marcaine HCL; Marcaine Spinal; Sensorcaine; Sensorcaine Forte; Sensorcaine-MPF; Sensorcaine-MPF Spinal; ...
Company Overview | Heron TherapeuticsCompany Overview | Heron Therapeutics
HTX-011 is our long-acting formulation of the local anesthetic bupivacaine in a fixed-dose combination with the anti-inflammatory meloxicam for the prevention of post-operative pain. Targeting both pain and inflammation has allowed HTX-011 to demonstrate an advantage over current standard of care in multiple surgical models-bunionectomy, hernia repair and abdominoplasty (tummy tuck)-in Phase 2 studies. Recently, Heron initiated patient enrollment in its Phase 3 program and anticipates completing the Phase 3 program in the first half of 2018. Heron expects to file an NDA for HTX-011 in 2018 ...
2019 ASHP Midyear2019 ASHP Midyear
Our portfolio includes two products approved by the US Food and Drug Administration, SUSTOL® (granisetron) and CINVANTI (aprepitant) injectable emulsion, as well as one product in development; HTX-011, a fixed-dose combination of the local anesthetic bupivacaine with the nonsteroidal anti-inflammatory drug (NSAID) meloxicam being investigated for application into the surgical site to reduce postoperative pain and the need for opioid analgesics for 72 hours.. Herons mission is to improve patients lives by developing best-in-class medicines that address major unmet medical needs. We are developing novel, patient-focused solutions that apply our innovative science and technologies to proven pharmacological agents.. ...
Bupivacaine | The Chopra LibraryBupivacaine | The Chopra Library
BACKGROUND: Interest in combining local and general anaesthesia has lead to studies investigating possible interactions. In a prospective, randomized, double-blind study, we tested whether local anaesthetics administered i.m. potentiate the hypnotic effect of propofol. METHODS: Sixty patients (three groups, n=20) undergoing lower abdominal surgery with total i.v. propofol anaesthesia were investigated. Patients in Group B received i.m. bupivacaine (5 mg ml(-1)) 1 mg kg(-1), patients in Group L received i.m. lidocaine (100 mg ml(-1)) 2 mg kg(-1) and patients in Group C received i.m ...
Post-cesarean Section Analgesic Safety and Efficacy of EXPAREL (Liposomal Bupivacaine) Infiltration Locally Versus Transversus...Post-cesarean Section Analgesic Safety and Efficacy of EXPAREL (Liposomal Bupivacaine) Infiltration Locally Versus Transversus...
Evaluating the safety and efficacy of EXPAREL (Liposomal Bupivacaine ) for pain control in patients undergoing scheduled cesarean section by giving it either
The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...
Multimodal analgesia following total hip arthroplasty has been shown to improve patient satisfaction, participation with physical therapy, and allow early return to self care. Liposomal bupivacaine is a formulation of local anesthetic which has the potential to provide anesthesia for up to 72 hours following administration. The purpose of this study was to compare the effectiveness of liposomal bupivacaine with bupivacaine following total hip arthroplasty. A retrospective chart review was performed on 28 patients undergoing total hip arthroplasty or hip resurfacing who received intraoperative administration of liposomal bupivacaine. A control group of 30 patients who had previously undergone total hip arthroplasty or hip resurfacing and had received intraoperative administration of bupivacaine also underwent a chart review. Length of stay, post-operative opioid use, and pain scores were compared for both groups. The average length of stay in the study group was 1.93 days and the control group length of
Influence of Voltage-sensitive Ca++Channel Drugs on Bupivacaine Infiltration Anesthesia in Mice | Anesthesiology | American...Influence of Voltage-sensitive Ca++Channel Drugs on Bupivacaine Infiltration Anesthesia in Mice | Anesthesiology | American...
Finally, the role of T-, P-, and Q-type channels in modulating sensory transduction at the level of nociceptors in skin remains to be investigated further. In our hands, the T-type Ca++channel blocker flunarizine failed to modulate bupivacaine anesthesia. In fact, flunarizine was inactive alone, and all three concentrations failed to affect the ED50value for bupivacaine (data not shown). Flunarizine has been reported to block Na+and L-type Ca++channels. Yet flunarizine did not enhance bupivacaine like the 1,4-dihydropyridines or elicit anesthesia like verapamil. Instead, the results indicate that T-type channels, if present on nociceptors, do not modulate bupivacaine anesthesia to noxious radiant heat. Infiltration of the P-type Ca++channel blocker ω-agatoxin IVA (0.063-0.48 μm) in the tail also failed to affect bupivacaine anesthesia. Yet several studies reported that P-type channels in the spinal cord block nociceptive input. Intrathecal ω-agatoxin IVA blocked formalin-induced nociception ...
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial | American Journal of...Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial | American Journal of...
BACKGROUND: Moderate to severe pain associated with the removal of pleural chest tubes is poorly controlled with opioids. New methods are needed to manage the pain associated with this procedure. OBJECTIVES: To compare the effects of interpleural injections of 0.25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients. METHODS: A randomized, double-blind, placebo-controlled trial was used, with a repeated measures design. Pain intensity and distress were measured before, immediately after, and 1 hour after chest tube removal. Pain sensations and affect were evaluated immediately after chest tube removal. The experimental group (n = 21) received bupivacaine and the control group (n = 20) received normal saline. RESULTS: In both groups pain intensity and distress scores were significantly higher at the time of chest tube removal than immediately before or 1 hour after. No significant differences in pain intensity, distress, ...
Ropivacaine - WikipediaRopivacaine - Wikipedia
Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur. Systemic exposure to excessive quantities of ropivacaine mainly result in central nervous system (CNS) and cardiovascular effects - CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures followed by depression (drowsiness, loss of consciousness), respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest - some of which may be due to hypoxemia secondary to respiratory depression.[2] ...
Tramadol as adjunct to psoas compartment block with levobupivacaine 0.5%: a randomized double-blinded study.Tramadol as adjunct to psoas compartment block with levobupivacaine 0.5%: a randomized double-blinded study.
BACKGROUND: Tramadol has been administered peripherally to prolong analgesia after brachial plexus and neuraxial blocks. Our aim was to evaluate the systemic and perineural effects of tramadol as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. METHODS: In a randomized, prospective, double-blinded trial, 60 patients (ASA I-III), aged 49-88 yr, undergoing primary total hip or knee arthroplasty underwent PCB and subsequent bupivacaine spinal anaesthesia. Patients were randomized into three groups. Each patient received PCB with levobupivacaine 0.5%, 0.4 ml kg(-1). The control group (group L, n=21) received i.v. saline, the systemic tramadol group (group IT, n=19) received i.v. tramadol 1.5 mg kg(-1) and the perineural tramadol group (group T, n=20) received i.v. saline and PCB with tramadol 1.5 mg kg(-1). Postoperatively patients received regular paracetamol 6-hourly and diclofenac sodium 12-hourly. Time to first morphine analgesia, 24-hour morphine consumption, sensory ...
Bupivacaine Hcl Introduction | acridinekBupivacaine Hcl Introduction | acridinek
Bupivacaine Hcl is accessible in concentrations of 0.25, 0.5, and 0.75% (2.5, 5, and 7.5 mg/mL, respectively) in single-dose containers. The 0.25 and 0.5% concentrations aswell appear in 50-mL multiple-dose vials with methylparaben 1 mg/mL as a preservative. Sodium hydroxide or hydrochloric acerbic is acclimated to acclimatize the pH. Bupivacaine Hcl is aswell accessible in…
Local Anesthetics Are Off-Label For Spinals | RK.mdLocal Anesthetics Are Off-Label For Spinals | RK.md
Note the lack of local anesthetics on that list. Lidocaine? No. Hyperbaric bupivacaine? No. Good ol tetracaine? Nope. All local anesthetics in the intrathecal space are off-label. Yet these are the very drugs that serve as the cornerstone for spinal anesthesia.. With a spinal needle and a few milliliters of local anesthetic like bupivacaine or lidocaine, we can achieve an anesthetic which enables surgeons to operate on the abdomen or lower extremities pain-free without any significant cardiopulmonary drawbacks. Sure, sympathectomies are a concern, but weve become extremely good at predicting and mitigating the effects of hypotension, tachy/bradycardias, etc ...
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry - Sleep and...Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry - Sleep and...
The final dataset included 38 subjects, 26 in the bupivacaine group and 12 in the saline group. A repeated measures analysis of variance showed that subjects receiving treatment with bupivacaine experienced a significant reduction in the numeric rating scale scores compared with those receiving saline at baseline (M = 3.78 vs M = 3.18, P = .10), 15 minutes (M = 3.51 vs M = 2.53, P , .001), 30 minutes (M = 3.45 vs M = 2.41, P , .001), and 24 hours after treatment (M = 4.20 vs M = 2.85, P , .001), respectively. Headache Impact Test-6 scores were statistically significantly decreased in subjects receiving treatments with bupivacaine from before treatment to the final treatment (Mdiff = -4.52, P = .005), whereas no significant change was seen in the saline group (Mdiff = -1.50, P = .13). CONCLUSION: SPG blockade with bupivacaine delivered repetitively for 6 weeks with the Tx360® device demonstrates promise as an acute treatment of headache in some subjects with CM. Statistically significant ...
Sphenopalatine Ganglion (SPG) Blocks | SPG Blocks | ChicagoSphenopalatine Ganglion (SPG) Blocks | SPG Blocks | Chicago
Sphenopalatine Ganglion - SPG Blocks Chicago. SPG Blocks have a hundred-year history of safety and efficacy. Contact Dr. Ira L. Shapira today.
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry -...Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry -...
The final dataset included 38 subjects, 26 in the bupivacaine group and 12 in the saline group. A repeated measures analysis of variance showed that subjects receiving treatment with bupivacaine experienced a significant reduction in the numeric rating scale scores compared with those receiving saline at baseline (M = 3.78 vs M = 3.18, P = .10), 15 minutes (M = 3.51 vs M = 2.53, P , .001), 30 minutes (M = 3.45 vs M = 2.41, P , .001), and 24 hours after treatment (M = 4.20 vs M = 2.85, P , .001), respectively. Headache Impact Test-6 scores were statistically significantly decreased in subjects receiving treatments with bupivacaine from before treatment to the final treatment (Mdiff = -4.52, P = .005), whereas no significant change was seen in the saline group (Mdiff = -1.50, P = .13). CONCLUSION: SPG blockade with bupivacaine delivered repetitively for 6 weeks with the Tx360® device demonstrates promise as an acute treatment of headache in some subjects with CM. Statistically significant ...
Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological...Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological...
Stream Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological Surgeons Journal Club from desktop or your mobile device
Comparison of Tramadol and Buprinorphine as an Adjuvent to Bupivacaine used in Supraclavicular brachial plexus block for upper...Comparison of Tramadol and Buprinorphine as an Adjuvent to Bupivacaine used in Supraclavicular brachial plexus block for upper...
Results: Onset of analgesia is fast with tramadol added to bupivacaine and time to achieve complete block without any increase in side- effects ...
Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using...Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using...
Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using mucopolysaccharide as chiral mobile phase additive
Is continuous perineural stump infusion of bupivacaine effective on acute and chronic postoperative stump pain? Could it reduce...Is continuous perineural stump infusion of bupivacaine effective on acute and chronic postoperative stump pain? Could it reduce...
Background. Chronic pain as the result of long-term peripheral arterial disease and critical limb ischemia is difficult to manage and needs a multidisciplinary approach (pharmacological, psychological and functional) especially when the patient undergoes a lower limb amputation. Amputees show high rates of acute postoperative pain and chronic phantom limb pain in which there are few satisfactory available treatments. Nevertheless, it has been suggested for many years that continuous regional infusion of local anesthetic during immediate postoperative period is an effective and safe way of reducing these complications, morphine consumption and opioids-related adverse effects. However, data is conflicting as to its efficacy for both short-and log-term outcomes. Objective. The purpose of this study is to investigate whether a continuous postoperative perineural infusion system with bupivacaine is effective in reduction of postoperative acute pain and morphine intake during the first 72 hours ...
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR...Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR...
This study aimed to test the hypothesis that levobupivacaine has anti-tumour effects on breast cancer cells. Colony formation and transwell assay were used to determine breast cancer cells proliferation. Flow Cytometry (annexin V and PI staining) was used to investigate breast cancer cells apoptosis. The effects of levobupivacaine on cellular signalling and molecular response were studied with Quantitative Polymerase Chain Reaction and western blot. Induction of apoptosis was confirmed by cell viability, morphological changes showed cell shrinkage, rounding, and detachments from plates. The results of the western blot and Quantitative Polymerase Chain Reaction indicated activation of active caspase-3 and inhibition of FOXO1. The results of the flow Cytometry confirmed that levobupivacaine inhibited breast cancer cell proliferation and enhanced apoptosis of breast cancer cells. Quantitative Polymerase Chain Reaction and Western blot analysis showed increased p21 and decreased cyclin D. Quantitative
Effects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. - Semantic ScholarEffects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. - Semantic Scholar
Semantic Scholar extracted view of [Effects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. by P Ben Driss et al.
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical SiteBupivacaine vs Placebo for Unilateral Mastectomy Surgical Site
Breast Cancer clinical trial. Clinical trial for Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control.
Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks...Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks...
Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks-IJCA-Print ISSN No:-2394-4781 Online ISSN No:-2394-4994Article DOI No:-10.18231/2394-4994.2019.0025,Indian Journal of Clinical Anaesthesia-IP Innovative Publication Pvt Limited, Medical Journ
Bupivacaine/hydromorphone Drug Interactions - Drugs.comBupivacaine/hydromorphone Drug Interactions - Drugs.com
825 medications are known to interact with bupivacaine/hydromorphone. Includes Advair Diskus (fluticasone/salmeterol), AndroGel (testosterone), Celebrex (celecoxib).
The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery - ICH GCP - Clinical...The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery - ICH GCP - Clinical...
Sixty neonates and infants will be enrolled and randomised into two groups of n=30 each . For their surgical procedures, one group general (GA) anaesthesia the second group will receive a combined general and epidural anaesthesia (CGEA). Anaesthetic technique: Patients in the GA group will be induced with intravenous propofol (2-4 mg.kg-1) and fentanyl (2-4 µg.kg-1) and will receive rocuronium bromide (0.5 mg.kg-1) to facilitate endotracheal intubation. Anaesthesia will be maintained with sevoflurane (2-3%) in an air/oxygen mixture as well as intravenous fentanyl as required. In the (CGEA) 0.5 ml.kg-1 of 0.25% bupivacaine will be injected into the epidural catheter, followed by a continuous infusion of 0.1% bupivacaine at a rate of 0.2 mg.kg-1.hr-1 for up to 48 hours postoperatively. Assessment of anaesthetic efficacy will be measured Intraoperative care vital signs. And will continuously be monitored with a Datex AS/3
PWE-399 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer | GutPWE-399 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer | Gut
Results 70 patients (43% female; mean age 60 (±13) years) were included. The intervention and controls groups included 35 patients each. Diagnoses included diverticulitis (72%), colonic malignancy (14%), benign neoplasm (10%) and inflammatory bowel disease (4%). The median number of port sites was 4 (3-5), where 39% of patients had a midline extraction site vs. 61% with a Pfannenstiel. Total incision length was 9.5cm in 63% of patients. No difference in total opioid use was identified between groups (61mg vs. 70mg; p = 0.51) on univariate analysis. A sensitivity analysis was used to account for extremes in opioid use by removing the outermost 10thpercentiles of opioid use; no difference was confirmed (59mg vs. 60mg; p = 0.98). LOS was similar in both groups (median 5 days), with no difference in AEs. There was no significant difference in time to first flatus or bowel movement (p = 0.23 and p = 0.35, respectively). A multivariate logistic regression adjusting for ketorolac and acetaminophen use ...
News Release - Investors - Pacira Pharmaceuticals, Inc.News Release - Investors - Pacira Pharmaceuticals, Inc.
EXPAREL and two other products have successfully utilized DepoFoam®, a unique and proprietary product delivery technology that encapsulates drugs without altering their molecular structure, and releases them over a desired period of time. Additional information about Pacira is available at www.pacira.com.. About EXPAREL®. EXPAREL (bupivacaine liposome injectable suspension) is currently indicated for single-dose infiltration into the surgical site to produce postsurgical analgesia. The product combines bupivacaine with DepoFoam®, a proven product delivery technology that delivers medication over a desired time period. EXPAREL represents the first and only multivesicular liposome local anesthetic that can be utilized in the peri- or postsurgical setting. By utilizing the DepoFoam platform, a single dose of EXPAREL delivers bupivacaine over time, providing significant reductions in cumulative pain score with a decrease in opioid consumption; the clinical benefit of the opioid reduction was not ...
Anesthesia, Epidural | The Chopra LibraryAnesthesia, Epidural | The Chopra Library
Spinal and epidural anaesthesia were compared in 65 patients undergoing hip arthroplasty, with regard to the degree of sensory and motor blockade, cardiovascular effects, operating conditions, the dose of propofol required to produce satisfactory hypnosis, and complications. Epidural anaesthesia was successful in 30 patients using an initial dose of 15 ml of 0.5% bupivacaine, and spinal anaesthesia in 32 patients, using 4 ml 0.5% isobaric bupivacaine. The two techniques were similar with regard to the level of sensory blockade (T8), degree of hypotension and perioperative haemorrhage ...
Particulate Matter Triggers Hospira Recall of InjectionParticulate Matter Triggers Hospira Recall of Injection
Hospira, a Pfizer company, has issued a recall of one lot of 0.25% Bupivacaine Hydrochloride Injection at the hospital/retail level due to the presence of particulate matter within a single vial. If administered to a patient, it may result in swelling, irritation, or allergic response.
Local Anesthetic Switching for Intrathecal Tachyphylaxis in... : Anesthesia & AnalgesiaLocal Anesthetic Switching for Intrathecal Tachyphylaxis in... : Anesthesia & Analgesia
A 47-yr-old woman with cervical cancer locally advanced and metastasized to the lung, mediastinum, and bones was admitted to the Pain Relief and Palliative Care Unit for severe lumbar and inguinal pain, which was aggravated by movement and caused by lumbar metastases. She had received different courses of chemotherapy and radiotherapy and was receiving a morphine slow-release preparation 180 mg daily, without reporting analgesic benefit. Opioid doses were increased up to 300 mg, but escalation was stopped because of the occurrence of drowsiness and vomiting. An intrathecal catheter was placed at the L3-4 level and was connected to a subcutaneous port and then to an external pump. A morphine/bupivacaine combination was given. The combination of the drugs was balanced to obtain the best analgesic effect with minimal neurological impairment in the lower limbs. The patient obtained adequate pain relief with doses of 8 mg of morphine and 40 mg of bupivacaine daily. Concentrations were adjusted to ...
ClinMed International LibraryClinMed International Library
Patients and Methods Following approval of the medical ethical committee of Ain Shams University, 40 patients ASA I-II physical status that were scheduled for elective urologic surgeries via abdominal wall incision under general anesthesia were included in this prospective study. All patients provided written informed consent. Patients with known allergy to any of the study medications, receiving medical therapies producing tolerance to opoids, with coagulapolly, and psychiatric problems were excluded. A preoperative evaluation was performed the day before surgery. Patients were divided into two groups: The TAP group (n=20) received TAP block with 0.25% bupivacaine (30mL) and infiltration group (n=20) the skin and subcutaneous tissues of the surgical incision and deep muscle layers were infiltrated with 0.25% bupivacaine (50ml), patients were monitored with electrocardiogram, invasive and non invasive arterial blood pressure, arterial oxygen saturation, end-tidal carbon dioxide monitoring. All ...
Local Anesthetic Toxicity Differential DiagnosesLocal Anesthetic Toxicity Differential Diagnoses
While generally safe, local anesthetic agents can be toxic if administered inappropriately, and in some cases may cause unintended reactions even when properly administered. Adverse effects are usually caused by high plasma concentrations of the agent, which may result from one of the following: Inadvertent intravascular injection Excessive d...
Bupivacaine Liposome (Injection Route) Precautions - Mayo ClinicBupivacaine Liposome (Injection Route) Precautions - Mayo Clinic
Tell your doctor or nurse right away if you have the following symptoms with this medicine: anxiety; blurred vision; depression; drowsiness; lightheadedness; nausea or vomiting; numbness and tingling of the mouth or lips; restlessness; ringing in the ears; speech problems; or tremors. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; fever; increased sweating; lightheadedness or fainting; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat after receiving this medicine. ...
Papers with the keyword epiphisiodesis | Read by QxMDPapers with the keyword epiphisiodesis | Read by QxMD
Moya Moya is a rare disease of uncertain origin, characterised by stenosis of one or both of the internal carotid arteries and responsible of several neurological signs. We present the case of a boy with Moya Moya disease who was scheduled for an epiphisiodesis of the lateral malleola and had a spinal anaesthesia with hyperbaric bupivacaine 0.5% 10 mg without any perioperative complications. Any anaesthetic method could be used, provided special attention is given to avoid changes of capnea and blood pressure to preserve cerebral blood flow and palliate to cerebral flow steal ...
Hospira, Inc. Articles, Photos, and Videos - CT NowHospira, Inc. Articles, Photos, and Videos - CT Now
Hospira Inc. announced June 17 it will initiate a voluntary nationwide recall to the user level for one lot of the anetsthetic 0.5% Marcaine¿ (Bupivacaine HCl Injection, USP), 30 mL, Single-dose Vial - Preservative Free (NDC 0409-1560-29), Lot 33-545-DD. The recall is due to a confirmed customer report of particulate embedded in the glass vial as well as visible particulate in the solution. To date, Hospira has not received reports of any adverse events associated with this issue for this lot. Hospira has attributed the embedded particulate to a suppliers glass defect. Hospira is working with its supplier on implementing corrective and preventive actions. Anyone with an existing... ...
Products | PaciraProducts | Pacira
Low- or no-opioid pain control is possible with EXPAREL EXPAREL® (bupivacaine liposome injectable suspension), is a local analgesic administered at the time of surgery to control pain and reduce or eliminate the use of opioids for acute postsurgical pain. When injected into the surgical site, EXPAREL turns off the bodys pain signals, numbing the area where surgery has occurred for several days following the procedure. To date, EXPAREL has been used in over 3 million patients.1
Article abstract | Medical Science MonitorArticle abstract | Medical Science Monitor
Background:In this prospective, randomized, placebo-controlled, double-blinded clinical trial we tested the hypothesis that preemptive analgesia with bupivacaine applied in the area of the surgical incision in patients undergoing mastectomy for breas...
Eagles-Cowboys up-down drillEagles-Cowboys up-down drill
It took us all season, but we decided to post Bob Brookovers up-down drill that appears in the newspaper, but someone never makes here online. So enjoy (we think) - Bob Brookover, Philadelphia Inquirer
Overview: The Communication Initiative | The Digital and Development NetworkOverview: The Communication Initiative | The Digital and Development Network
Overview: The Communication Initiative Visión general: La Iniciativa de Comunicación (Por favor vea la traducción en español a continuación) THE COMMUNICATION INITIATIVE - Strategic Positioning and Added Value Mission: Convene the communication and media development, social and behavioural change community for more effective local, national, and in
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Our staffs have been inactive, so new staff positions have been made.. Congratulations to Izaya and Savic for being our new Local Moderators. Sorry to Salmonhea
Anaesthesia-Intensive care.com: RENAL FAILURE INVESTIGATIONAnaesthesia-Intensive care.com: RENAL FAILURE INVESTIGATION
Are These Wellens Waves?? - *This is a repost. Ive received a few questions like this, so wanted to re-inforce the idea of down-up vs. up-down T-waves* *Case:* One of our residents... ...
Anaesthesia-Intensive care.com: NHS worksAnaesthesia-Intensive care.com: NHS works
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Management of strabismusManagement of strabismus
Ugi reactionUgi reaction
LevobupivacaineLevobupivacaine
LidocaineLidocaine
Botulinum toxin therapy of strabismusBotulinum toxin therapy of strabismus
Potassium channelPotassium channel
NeosaxitoxinNeosaxitoxin
Pipecolic acidPipecolic acid
DNA vaccinationDNA vaccination
Local anesthetic nerve blockLocal anesthetic nerve block
Local anestheticLocal anesthetic
RopivacaineRopivacaine
Epidural administrationEpidural administration
Lipid emulsionLipid emulsion
2,6-Xylidine2,6-Xylidine
SameridineSameridine
Combined spinal and epidural anaesthesiaCombined spinal and epidural anaesthesia
AstraZenecaAstraZeneca
Anaesthesia for ocular surgeryAnaesthesia for ocular surgery
Schedule HSchedule H
Ion trappingIon trapping
Bryan L. ReussBryan L. Reuss
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Veterinary surgeryVeterinary surgery
PhacoemulsificationPhacoemulsification
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BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceAnalgesia, Patient-ControlledMorphineBrachial PlexusLabor, ObstetricDose-Response Relationship, DrugProcaineInjections, EpiduralAmbulatory Surgical ProceduresPregnancyPrilocaineEpinephrineSpecific GravitySciatic NerveThoracotomyHernia, InguinalHydromorphoneHydrocodoneAlbuterolOxymorphoneAndrostadienesDrug InteractionsAnaphylaxisSpeech DisordersPostural Orthostatic Tachycardia SyndromeDizzinessNanospheresTremor
Bupivacaine & Adrenaline 0.5% - Drugs.comBupivacaine & Adrenaline 0.5% - Drugs.com
Bupivacaine 25mg/10ml (0.25%) inj ampoules | LloydsPharmacyBupivacaine 25mg/10ml (0.25%) inj ampoules | LloydsPharmacy
Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLinkComparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLink
Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | CirculationStereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. | Sigma...Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. | Sigma...
Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2
Bupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiBupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin CellsEffect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
Bupivacaine impurity B (2RS)-N-(2,6-dimethylphenyl)piperidine-2-carboxamide- CAS Number 65797-42-4Bupivacaine impurity B (2RS)-N-(2,6-dimethylphenyl)piperidine-2-carboxamide- CAS Number 65797-42-4
FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...
Continuous infusion bupivacaine via an elastomeric pumpContinuous infusion bupivacaine via an elastomeric pump
Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...
Bupivacaine | The Chopra LibraryBupivacaine | The Chopra Library
Bupivacaine hydrochloride,monohydrate,usp - Alfa ChemistryBupivacaine hydrochloride,monohydrate,usp - Alfa Chemistry
Bupivacaine-induced myocardial depression and pulmonary edema:...Bupivacaine-induced myocardial depression and pulmonary edema:...
99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik
Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...
A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...
Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...
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June 21, 2020 - Food & Beverage HeraldJune 21, 2020 - Food & Beverage Herald
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureHealth Care
BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceAnalgesia, Patient-ControlledMorphineBrachial PlexusLabor, ObstetricDose-Response Relationship, DrugProcaineInjections, EpiduralAmbulatory Surgical ProceduresPregnancyPrilocaineEpinephrineSpecific GravitySciatic NerveThoracotomyHernia, InguinalHydromorphoneHydrocodoneAlbuterolOxymorphoneAndrostadienesDrug InteractionsAnaphylaxisSpeech DisordersPostural Orthostatic Tachycardia SyndromeDizzinessNanospheresTremor
Analgesia0.25SpinalLevobupivacaineEffects of bupivacaineLidocaineMorphineMarcaineSignificantlyAnesthesiaSalineDoseAnestheticsMixtureAbstractDexmedetomidineSodiumContinuousBlockadeAdrenalinePainLocalEpiduralEpinephrineLidocaineIntrathecal bupivacaineLiposome injectableAnalgesiaFentanylInjected with liposomal bupivacaineToxicityExtended-release bupivacaineSuppressed bupivacaine-inducedAnalgesicInjection of bupivacaineContraindicated in patients withConcentrationsAnestheticBrachial plexus blockDose of hyperbaric bupivacaineRacemic0.75Side effects of bupivacaineAmideEfficacy of liposomalLiposomal bupivacaine infiltrationDosesSpinal anaesthesiaSurgicalIntra-articularCardiotoxicMedicationForms of bupivacaineIndicate that bupivacaineFormulations of BupivacaineEffectivenessHypotensionFormulationPeripheralApoptosisContains bupivacaineDouble-blind randomized studyPatientsSurgery
Analgesia2
0.251
  • In practice 3 X 10 ml ampoules of bupivacaine 0.25 solution with adrenaline 1 200 000 are admixed with 3 X 10 ml ampoules of 1 ligno-caine to produce 3 X 20 ml. (ormedmedical.us)
Spinal1
Levobupivacaine4
Effects of bupivacaine1
Lidocaine1
Morphine4
Marcaine2
Significantly1
  • However, cellular levels of p62 protein were significantly increased upon bupivacaine treatment (1.29 ± 0.15 vs. 1.00 ± 0.15), suggesting that the drug impaired autophagosome clearance. (sigmaaldrich.com)
Anesthesia1
Saline1
  • Women received either 15 ml of 0.9% saline (n=42) or 15 ml of 0.5% bupivacaine (n=43), which was instilled intraperitoneally. (elsevier.com)
Dose1
  • HTX-011, a fixed-dose combination of the local anesthetic bupivacaine with the nonsteroidal anti-inflammatory drug (NSAID) meloxicam being investigated for application into the surgical site to reduce postoperative pain and the need for opioid analgesics for 72 hours. (jspargo.com)
Anesthetics2
Mixture2
  • The recommended local anaesthetic agent is a mixture of bupivacaine and lignocaine with the addition of adrenaline 1 200 000. (ormedmedical.us)
  • The benefits of this mixture are the rapid onset of action of the lignocaine solution, the prolonged action of the bupivacaine and the possibility of reduced local haemorrhage with the addition of adrenaline. (ormedmedical.us)
Abstract1
  • abstract = "The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. (elsevier.com)
Dexmedetomidine1
Sodium1
  • These findings suggest myocardial depression owing to bupivacaine sodium channel blocking of myocardial nerve and tissue and subsequent reduction of myocardial contractility. (mysciencework.com)
Continuous1
  • Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response and pulmonary function following cholecystectomy. (regionh.dk)
Blockade1
  • Motor blockade was observed between one and three hours in treatments using bupivacaine. (bmj.com)
Adrenaline1
Pain1
  • Twenty patients undergoing elective cholecystectomy were prospectively randomised to receive either intrapleural (bolus 20 ml followed by 10 ml/h) or thoracic epidural (bolus 9 ml followed by 5 ml/h) bupivacaine 0.5% for 8 h postoperatively to assess the effect of these two techniques on pain, pulmonary function and the surgical stress response. (regionh.dk)
Local2
Epidural18
Epinephrine16
Lidocaine7
Intrathecal bupivacaine7
Liposome injectable4
Analgesia12
Fentanyl15
Injected with liposomal bupivacaine1
Toxicity5
  • a lipid infusion such as propofol increases the dose of bupivacaine required to induce cardiac arrest, and, therefore, this strategy has been suggested as a potential means to improve outcomes from such toxicity. (lww.com)
  • The higher potency of R (+)-bupivacaine to block the inactivated state of the cardiac Na + channel may explain its higher toxicity because of the large contribution of the inactivated-state block during the plateau phase of the cardiac action potential. (ahajournals.org)
  • A serum bupivacaine concentration, obtained 2.5 hours after injection, was 0.76 mcg per mL, which is consistent with previous reports of bupivacaine toxicity 1 and higher than bupivacaine concentrations reported in older boys after circumcision. (aafp.org)
  • 6 This case exemplifies the principle that relatively small volumes of bupivacaine may result in local anesthetic toxicity. (aafp.org)
  • Acute bupivacaine toxicity as a result of venous leakage under the tourniquet cuff during a Bier block. (aafp.org)
Extended-release bupivacaine6
Suppressed bupivacaine-induced1
  • GB suppressed bupivacaine-induced mitochondrial depolarization and mitochondria complex I and III inhibition and increased cleaved caspase-3 and Htra2 expression, which was strongly indicative of activation of mitochondria-dependent apoptosis with concomitantly enhanced expressions of Grp78, caspase-12 mRNA, protein, and ER stress. (hindawi.com)
Analgesic4
Injection of bupivacaine2
Contraindicated in patients with1
Concentrations4
Anesthetic17
Brachial plexus block2
  • Results published in Orthopedics showed similar efficacy between injectable liposomal bupivacaine and an interscalene brachial plexus block among patients who underwent total shoulder arthroplasty. (healio.com)
  • Patients and Methods: Fifty-six patients under- going elective forearm and hand surgery under supraclavicular brachial plexus block were allocated randomly into one of two groups of 28 patients each to receive either 25 ml (0.5%) bupivacaine with 1 ml of NS or 25 ml (0.5%) bupivacaine with 1 ml (20 mg) nalbuphine. (scirp.org)
Dose of hyperbaric bupivacaine1
Racemic3
0.752
  • A "heavy" solution (0.75% bupivacaine in 8.25% glucose) will provide the muscular relaxation required for abdominal surgery. (who.int)
  • An expanded recall was issued on August 29, 2013 for one lot of 0.75% Bupivacaine HCl Injection, USP (7.5 mg/mL), 30 mL Single-dose Vial (NDC 0409-1165-02). (asahq.org)
Side effects of bupivacaine1
  • What are the possible side effects of bupivacaine? (cigna.com)
Amide3
  • Bupivacaine is related chemically and pharmacologically to the amide-type local anesthetics. (rxlist.com)
  • Bupivacaine is an amide local anaesthetic used in hyperbaric and isobaric forms. (cochrane.org)
  • All local anesthetics contain three structural components: an aromatic ring, a connecting group which is either an ester (procaine) or an amide (bupivacaine), and an ionizable amine group. (statpearls.com)
Efficacy of liposomal1
Liposomal bupivacaine infiltration1
  • This study aimed to evaluate the effect of liposomal bupivacaine infiltration on total amount of opioid use, incidence of AEs and length of stay (LOS) after minimally invasive (MIS) sigmoid coloctomy. (bmj.com)
Doses7
  • Unsurprisingly, the researchers found that patients who received liposomal bupivacaine following complex cytoreductive surgery required significantly fewer doses of intravenous opioids during the first and second postoperative days than those whose pain was managed with bupivacaine HCl. (obgyn.net)
  • This prospective, randomized, clinical study was performed in 80 patients who were assigned to four groups to receive different doses of intrathecal hyperbaric bupivacaine (5 mg, 7.5 mg, 10 mg and 12.5 mg in Groups 1, 2, 3, and 4 respectively). (dovepress.com)
  • Unilateral sensory and motor block can be achieved with doses of 5 mg and 7.5 mg hyperbaric bupivacaine 0.5% with a stable hemodynamic state. (dovepress.com)
  • He received two 1-mL doses of 0.5% bupivacaine, spaced apart by two to three minutes. (aafp.org)
  • The primary objective of this randomised clinical study was to evaluate the frequency of unilateral block when different doses of hypobaric bupivacaine solution were used for single limb orthopaedic surgery. (thefreelibrary.com)
  • The proposed study aims to investigate the effect of three different doses of oral clonidine on subarachnoid block, anxiolysis, sedation, hemodynamic stability and their side effects, in patients undergoing surgeries below umbilicus in order to find out its optimum dose as a premedication agent with spinal anaesthesia Bupivacaine . (omicsonline.org)
  • Bupivacaine may be neurotoxic at high doses, activating p38 MAPK, increasing levels of ROS and WDR53, and inducing apoptosis in neuroblastoma cells. (lktlabs.com)
Spinal anaesthesia4
  • This Cochrane Review summarizes the best available evidence for the effectiveness and safety of the denser form of bupivacaine compared to the isobaric form when spinal anaesthesia (injection of medications into the lower back) is used for delivery of a baby by caesarean section. (cochrane.org)
  • We included all randomized controlled trials (RCTs) involving parturients undergoing spinal anaesthesia for elective caesarean section that compared the use of hyperbaric with isobaric bupivacaine. (cochrane.org)
  • Preoperative oral clonidine 4 μg kg-1 appears to be the optimum dose for optimization of spinal anaesthesia with bupivacaine as it prolongs the sensory block maximally with minimal side effects. (omicsonline.org)
  • Bupivacaine is the most common drug used in the spinal anaesthesia but its high dosage is associated with the increased incidence of hypotension [ 8 ]. (alliedacademies.org)
Surgical7
Intra-articular1
Cardiotoxic2
Medication7
  • Bupivacaine is available as a generic medication and is not very expensive. (wikipedia.org)
  • Bupivacaine may also be used for purposes not listed in this medication guide. (cigna.com)
  • This is a research study testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
  • This is a research study of SABER® -Bupivacaine, an experimental medication designed to relieve pain up to 3 days after surgery. (bioportfolio.com)
  • This is an extension to a previous research trial testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
  • Bupivacaine added to liposomal bupivacaine addressed the delayed onset of this medication and gave an accurately matched comparison with the ropivacaine cocktail. (healio.com)
  • In the case of bupivacaine, there are no specific foods that you must exclude from your diet when receiving this medication. (rxwiki.com)
Forms of bupivacaine1
Indicate that bupivacaine2
  • Conclusions Both the large level of pulse-dependent block and the failure of the pure inactivated-state block model indicate that bupivacaine interacts with the activated (or open) state of the cardiac sodium channel in addition to its block of the inactivated state. (ahajournals.org)
  • These data indicate that bupivacaine is not transported through the brain capillary wall, i.e., the blood-brain barrier, from the bovine albumin-bound pool, but bupivacaine is partially available for transfer from the circulating AAG-bound pool. (aspetjournals.org)
Formulations of Bupivacaine2
  • Different formulations of bupivacaine are not bioequivalent even if the milligram strength is the same. (rxlist.com)
  • see Non-Interchangeability with Other Formulations of Bupivacaine ]. (rxlist.com)
Effectiveness1
  • The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. (wiley.com)
Hypotension2
  • In this study, we tried to solve this challenge by increasing the dose of bupivacaine to achieve a proper spinal level accompanied by prolonged sitting up to avoid hypotension. (nih.gov)
  • Most common complication was hypotension, detected in 16 (66.7%) levobupivacaine group patients and in 10 (43.5%) bupivacaine group patients (p = 0.11). (scielo.br)
Formulation1
Peripheral1
Apoptosis7
  • These results implicate bupivacaine-induced ROS-dependent mitochondria, ER dysfunction, and apoptosis, which can be attenuated by GB through its antioxidant property. (hindawi.com)
  • For example, bupivacaine may inhibit mitochondrial respiratory complexes I and III, leading to decreased ATP production, collapse of the mitochondrial membrane potential (Δ ψ m), overproduction of reactive oxygen species (ROS), and ultimately liberation of cytochrome c and activation of the caspase-3-dependent apoptosis pathway [ 10 - 12 ]. (hindawi.com)
  • DRG was prepared from adult C57BL/6 mice and incubated with 10 mM bupivacaine in vitro to induce apoptosis. (ovid.com)
  • SiRNA-mediated TNF-α or TNF-R1 inhibition, but not TNF-R2 inhibition, rescued bupivacaine-induced DRG apoptosis. (ovid.com)
  • In other cellular models, bupivacaine induces depolarization of the mitochondrial membrane potential, resulting in apoptosis. (lktlabs.com)
  • Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. (lktlabs.com)
  • Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. (lktlabs.com)
Contains bupivacaine2
  • Each vial contains bupivacaine at a nominal concentration of 13.3 mg/mL. (rxlist.com)
  • The novel delivery system contains bupivacaine within a carrier molecule that allows gradual release over an extended period. (healio.com)
Double-blind randomized study1
Patients16
  • patients treated with femoral nerve block used twice as much as those treated with bupivacaine. (medscape.com)
  • However, elderly patients are more likely to have low blood pressure or kidney problems, which may require caution and an adjustment in the dose for patients receiving bupivacaine injection. (mayoclinic.org)
  • We included 53 patients in this study whom were randomly divided into two groups, namely Group B and Group C. In Group B (25 patients), each patient received 3 mL of bupivacaine and left 5 min sitting up, whereas in Group C (28 patients), each patient received 2.5 mL of bupivacaine and was asked to lie supine immediately. (nih.gov)
  • High blood levels of bupivacaine must be avoided in patients with hepatic impairment. (who.int)
  • The objective of this study was to compare the block durations and haemodynamic effects associated with intrathecal levobupivacaine or bupivacaine in elderly patients undergoing transurethral prostate surgery. (biomedsearch.com)
  • Participated in this study 47 patients being 24 in the levobupivacaine group and 23 in the bupivacaine group. (scielo.br)
  • Using liposomal bupivacaine to control pain in patients after gynecological surgery reduced the amount of narcotics needed and may lead to faster recovery times, a recent study found. (obgyn.net)
  • During the first day following surgery, 21.5% of the patients treated with liposomal bupivacaine required opioids, while 46.9% of patients who received bupivacaine HCI were given opioids to control pain. (obgyn.net)
  • By day two, just 7.4% of patients treated with liposomal bupivacaine were given opioids compared with 27.2% in the other group. (obgyn.net)
  • RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included. (ivteam.com)
  • Conclusion When added to an aggressive ERP, liposomal bupivacaine does not decrease the amount of total opioid consumption, the incidence of AEs or the LOS in patients undergoing MIS sigmoid resection. (bmj.com)
  • Among patients undergoing shoulder arthroplasty, liposomal bupivacaine was shown to provide better pain relief at 19 to 21 weeks post-surgery with fewer complications compared with continuous interscalene nerve block, according to research published in the Journal of Shoulder & Elbow Surgery . (clinicalpainadvisor.com)
  • In this prospective clinical trial, 70 patients undergoing shoulder arthroplasty were randomly assigned to receive continuous interscalene nerve block (n=36) or liposomal bupivacaine (n=34) with a single bolus interscalene block. (clinicalpainadvisor.com)
  • We performed real-time ultrasound guidance for infraorbital nerve blocks in TN patients using a high concentration of tetracaine dissolved in bupivacaine. (deepdyve.com)
  • All patients could not continue drug therapy with carbamazepine due to side effects and they received an ultrasound-guided infraorbital nerve block with a high concentration of tetracaine dissolved in bupivacaine.MethodsThe patient was placed in the supine position and the patient's face was sterilized and draped. (deepdyve.com)
  • However, elderly patients are more likely to have kidney or liver problems, which may require caution for patients receiving bupivacaine liposome injection. (findatopdoc.com)
Surgery7
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