AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
BupivacaineAnesthetics, LocalAnesthesia, SpinalAnalgesia, EpiduralAmidesAnalgesia, ObstetricalAnesthesia, EpiduralAnesthesia, ObstetricalNerve BlockLidocainePain, PostoperativeAnesthesia, CaudalEtidocaineAnesthesia, LocalSufentanilFentanylAnesthetics, CombinedDouble-Blind MethodAdjuvants, AnesthesiaMepivacaineInjections, SpinalCesarean SectionCarticaineAnalgesics, OpioidPain MeasurementAnalgesiaStereoisomerismSensationSubarachnoid SpaceAnalgesia, Patient-ControlledMorphineBrachial PlexusLabor, ObstetricDose-Response Relationship, DrugProcaineInjections, EpiduralAmbulatory Surgical ProceduresPregnancyPrilocaineEpinephrineSpecific GravitySciatic NerveThoracotomyHernia, Inguinal
Bupivacaine
A widely used local anesthetic agent.
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Anesthesia, Spinal
Procedure in which an anesthetic is injected directly into the spinal cord.
Analgesia, Epidural
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
Amides
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Analgesia, Obstetrical
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
Anesthesia, Epidural
Procedure in which an anesthetic is injected into the epidural space.
Anesthesia, Obstetrical
A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.
Nerve Block
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Lidocaine
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Pain, Postoperative
Pain during the period after surgery.
Anesthesia, Caudal
Epidural anesthesia administered via the sacral canal.
Etidocaine
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
Anesthesia, Local
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
Sufentanil
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Fentanyl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Anesthetics, Combined
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Adjuvants, Anesthesia
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Mepivacaine
A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Injections, Spinal
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Cesarean Section
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
Carticaine
A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
Analgesics, Opioid
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Pain Measurement
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Analgesia
Methods of PAIN relief that may be used with or in place of ANALGESICS.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Sensation
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
Subarachnoid Space
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
Analgesia, Patient-Controlled
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
Morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Brachial Plexus
The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
Labor, Obstetric
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Procaine
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
Injections, Epidural
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
Ambulatory Surgical Procedures
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Prilocaine
A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Specific Gravity
The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Thoracotomy
Surgical incision into the chest wall.
Hernia, Inguinal
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.

Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers. (1/1144)

BACKGROUND: Intrathecal adjuncts often are used to enhance small-dose spinal bupivacaine for ambulatory anesthesia. Neostigmine is a novel spinal analgesic that could be a useful adjunct, but no data exist to assess the effects of neostigmine on small-dose bupivacaine spinal anesthesia. METHODS: Eighteen volunteers received two bupivacaine spinal anesthetics (7.5 mg) in a randomized, double-blinded, crossover design. Dextrose, 5% (1 ml), was added to one spinal infusion and 6.25, 12.5, or 50 microg neostigmine in dextrose, 5%, was added to the other spinal. Sensory block was assessed with pinprick; by the duration of tolerance to electric stimulation equivalent to surgical incision at the pubis, knee, and ankle; and by the duration of tolerance to thigh tourniquet. Motor block at the quadriceps was assessed with surface electromyography. Side effects (nausea, vomiting, pruritus, and sedation) were noted. Hemodynamic and respiratory parameters were recorded every 5 min. Dose-response relations were assessed with analysis of variance, paired t tests, or Spearman rank correlation. RESULTS: The addition of 50 microg neostigmine significantly increased the duration of sensory and motor block and the time until discharge criteria were achieved. The addition of neostigmine produced dose-dependent nausea (33-67%) and vomiting (17-50%). Neostigmine at these doses had no effect on hemodynamic or respiratory parameters. CONCLUSIONS: The addition of 50 microg neostigmine prolonged the duration of sensory and motor block. However, high incidences of side effects and delayed recovery from anesthesia with the addition of 6.25 to 50 microg neostigmine may limit the clinical use of these doses for outpatient spinal anesthesia.  (+info)

A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. (2/1144)

BACKGROUND: This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. METHODS: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 ml bupivacaine, 0.125%, plus 7.5 microg sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 microg sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. RESULTS: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/-15 min and lasted +/-90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P<0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. CONCLUSIONS: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade.  (+info)

Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles. (3/1144)

BACKGROUND: Although various local anesthetics can cause histologic damage to skeletal muscle when injected intramuscularly, bupivacaine appears to have an exceptionally high rate of myotoxicity. Research has suggested that an effect of bupivacaine on sarcoplasmic reticulum Ca2+ release is involved in its myotoxicity, but direct evidence is lacking. Furthermore, it is not known whether the toxicity depends on the unique chemical characteristics of bupivacaine and whether the toxicity is found only in skeletal muscle. METHODS: The authors studied the effects of bupivacaine and the similarly lipid-soluble local anesthetic, tetracaine, on the Ca2+ release channel-ryanodine receptor of sarcoplasmic reticulum in swine skeletal and cardiac muscle. [3H]Ryanodine binding was used to measure the activity of the Ca2+ release channel-ryanodine receptors in microsomes of both muscles. RESULTS: Bupivacaine enhanced (by two times at 5 mM) and inhibited (66% inhibition at 10 mM) [3H]ryanodine binding to skeletal muscle microsomes. In contrast, only inhibitory effects were observed with cardiac microsomes (about 3 mM for half-maximal inhibition). Tetracaine, which inhibits [3H]ryanodine binding to skeletal muscle microsomes, also inhibited [3H]ryanodine binding to cardiac muscle microsomes (half-maximal inhibition at 99 microM). CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic. Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics. The specific action of tetracaine to inhibit Ca2+ release channel-ryanodine receptor activity may in part counterbalance the nonspecific action, resulting in moderate myotoxicity.  (+info)

Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery. (4/1144)

We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or placebo. During the first 24 h after surgery, all patients received 4 ml h-1 of epidural bupivacaine 2.5 mg ml-1. From 24 to 48 h after operation, patients received epidural morphine 0.2 mg h-1 preceded by a bolus dose of 2 mg. In addition, patient-controlled analgesia (PCA) with i.v. morphine (2.5 mg, lockout time 15 min) was offered from 0 to 48 h after operation. Patients who received ketamine felt significantly more sedated at 0-24 h, but not at 24-48 h after operation, compared with patients who received placebo (P = 0.002 and P = 0.127, respectively). There were no significant differences in pain (VAS) at rest, during mobilization or cough, PCA morphine consumption, sensory block to pinprick, pressure pain detection threshold assessed with an algometer, touch and pain detection thresholds assessed with von Frey hairs, peak flow or side effects other than sedation. The power of detecting a reduction in VAS scores of 20 mm in our study was 80% at the 5% significance level. We conclude that we were unable to demonstrate an (additive) analgesic or opioid sparing effect of ketamine 10 mg h-1 i.v. combined with epidural bupivacaine at 0-24 h, or epidural morphine at 24-48 h after renal surgery.  (+info)

Neonatal outcome and mode of delivery after epidural analgesia for labour with ropivacaine and bupivacaine: a prospective meta-analysis. (5/1144)

In this prospective meta-analysis, we have evaluated the effect of epidural analgesia with ropivacaine for pain in labour on neonatal outcome and mode of delivery compared with bupivacaine. In six randomized, double-blind studies, 403 labouring women, primigravidae and multiparae, received epidural analgesia with ropivacaine or bupivacaine 2.5 mg ml-1. The drugs were administered as intermittent boluses in four studies and by continuous infusion in two. Apgar scores, neurological and adaptive capacity scores (NACS), degree of motor block and mode of delivery were recorded. The studies were designed prospectively to fit meta-analysis of the pooled results. Results showed similar pain relief and consumption of the two drugs. In the vaginally delivered neonates, NACS scores were approximately equal for both groups at 2 h, but at 24 h there were fewer infants with NACS less than 35 in the ropivacaine compared with the bupivacaine group (2.8% vs 7.6%; P < 0.05). Spontaneous vaginal deliveries occurred more frequently overall with ropivacaine than with bupivacaine (58% vs 49%; P < 0.05) and instrumental deliveries (forceps and vacuum extraction) less frequently (27% vs 40%; P < 0.01), while the frequency of Caesarean section was similar between groups. The intensity of motor block was lower with ropivacaine. There were no significant differences in adverse events.  (+info)

Incidence of bradycardia during recovery from spinal anaesthesia: influence of patient position. (6/1144)

We administered 0.5% plain bupivacaine 4 ml intrathecally (L2-3 or L3-4) in three groups of 20 patients, according to the position in which they were nursed in the post-anaesthesia care unit (PACU): supine horizontal, 30 degrees Trendelenburg or hammock position (trunk and legs 30 degrees elevated). Patients were observed until anaesthesia descended to less than S1. The incidence of severe bradycardia (heart rate < 50 beat min-1) in the PACU was significantly higher in patients in the Trendelenburg position (60%) than in the horizontal (20%, P < 0.01) or hammock (10%, P < 0.005) position. After 90 min, following admission to the PACU, only patients in the hammock position did not have severe bradycardia. In this late phase, the incidence of severe bradycardia in the Trendelenburg group was 35% (P < 0.005) and 10% in patients in the supine horizontal position. In four patients, severe bradycardia first occurred later than 90 min after admission to the PACU. The latest occurrence of severe bradycardia was recorded 320 min after admission to the PACU. We conclude that for recovery from spinal anaesthesia, the Trendelenburg position should not be used and the hammock position is preferred.  (+info)

Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. (7/1144)

We studied 32 patients undergoing bilateral symmetrical lower third molar surgery under general anaesthesia to determine if the combined effects of pre-emptive local anaesthetic block using 0.5% bupivacaine, together with i.v. tenoxicam and alfentanil had any benefits over postoperative administration. Patients acted as their own controls and were allocated randomly to have surgery start on one side, the second side always being the pre-emptive side. Difference in pain intensity between the two sides was determined using visual analogue scales completed by each individual at 6 h, and at 1, 3 and 6 days after operation. A long-form McGill pain questionnaire was also used to assess difference in pain intensity between the two sides on the morning after surgery. There was no significant difference in pain intensity at any time after surgery. Our findings indicate that the combined use of pre-emptive analgesia from 0.5% bupivacaine, tenoxicam and alfentanil did not reduce postoperative pain intensity in patients undergoing molar exodontia.  (+info)

Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. (8/1144)

BACKGROUND: The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to assess the relative analgesic potencies of epidural bupivacaine and ropivacaine by determining their respective minimum local analgesic concentrations. METHODS: Seventy-three parturients at < or = 7 cm cervical dilation who requested epidural analgesia were allocated to one of two groups in this double-blinded, randomized, prospective study. After a lumbar epidural catheter was placed, 20 ml of the test solution was given, either ropivacaine (n = 34) or bupivacaine (n = 39). The concentration of local anesthetic was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. Analgesic efficacy was assessed using 100-mm visual analog pain scores with < or = 10 mm within 30 min defined as effective. An effective result directed a 0.01% wt/vol decrement for the next patient. An ineffective result directed a 0.01% wt/vol increment. RESULTS: The minimum local analgesic concentration of ropivacaine was 0.111% wt/vol (95% confidence interval, 0.100-0.122), and the minimum local analgesic concentration of bupivacaine was 0.067% wt/vol (95% confidence interval, 0.052-0.082). Ropivacaine was significantly less potent than bupivacaine, with a potency ratio of 0.6 (95% confidence interval, 0.49-0.74). No difference in motor effects was observed. CONCLUSION: Ropivacaine was significantly less potent than bupivacaine for epidural analgesia in the first stage of labor.  (+info)

In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...
Background and Aims: The effect of local anesthetics on myometrial contractility during labor analgesia is debatable. We aimed to compare the effects of bupivacaine and levobupivacaine on rat uterine contractility in an in vivo setting. Methods: Electrical activities of 40 pregnant rat uteruses were recorded on electrohysterogram after dividing the rats into bupivacaine and levobupivacaine groups. Uterine contraction frequencies were recorded at each 5-min interval. The first 5-min recording was considered the control, which was immediately followed by intramyometrial administration of either bupivacaine or levobupivacaine. The recordings were continued for 30 min. The changes in frequencies at each time interval of the groups were compared with each other and the control recording. Results: The frequencies from both groups at each interval were lower than the control values, but not different between the groups. The frequencies of the bupivacaine group during the 5-10 min and 10-15 min ...
https://avesis.medeniyet.edu.tr/yayin/3be99c61-d995-40ca-9128-9e705cc8aa51/in-vivo-comparison-of-the-effects-of-bupivacaine-and-levobupivacaine-on-the-pregnant-rat-myometrium-using-electrohysterogram
Comparative antibacterial activity of synthetic N,S-Heterocyclic derivatives, MgO nanoparticles, and glycine on zoonotic Vibrio...Comparative antibacterial activity of synthetic N,S-Heterocyclic derivatives, MgO nanoparticles, and glycine on zoonotic Vibrio...
Background: Vibrio fluvialis is an emerging zoonotic pathogen that its antibiotic-resistant strains are rapidly expanding. Discovering new antibacterial agents is one way to control it.Aims and Objectives: In this research, inhibitory potentials of glycine, magnesium oxide nanoparticles (NPs), and some synthesized thiazole, imidazolidine-2-thione, and tetrahydropyrimidine-2-thione derivatives were studied against V. 﫿uvialis in an in vitro manner.Materials and Methods: Thiazoles were prepared through Hantzsch reaction. Cyclic thioureas were synthesized from the reaction of diaminoalkanes and carbon disulfde. MgO NPs were created in 23.7-25.7nm by sol-gel processing. Antibacterial properties of all compounds as inhibition zone diameter, the minimum inhibitory concentration, and the minimum bactericidal concentration values were assessed through both disk diffusion and broth microdilution methods.Results: No inhibitory activity on V. 﫿uvialis was observed with MgO NPs and glycine. Among ...
http://www.jrpsjournal.com/printarticle.asp?issn=2322-1232
Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...
Background: Spinal anaesthesia is the fastest and most reliable form of regional anaesthesia. Additions of intrathecaly adjuvants are useful for prolonging the spinal anaesthesia effects.Subjects and Methods:The Patients were divided in three groups; Group C (control group) = received 15 mg (3 ml) of hyperbaric bupivacaine intrathecaly. Group D = received 15 mg (3 ml) of hyperbaric bupivacaine plus 4μgDexmedetomidine intrathecally. Group F = received Hyperbaric Bupivacaine 15mg (3ml) plus 25μg fentanylintrathecally.Results: For the total duration of sensory block p- value is 0.000003, which is less than 0.05 (α) and is highly significant. From the above p - value and scheffe post hoc test we conclude that the Bupivacaine + Dexmedetomidine has prolonged duration of sensory block as compared to bupivacaine alone and in combination with fentanyl. For the motor block p- value is 0.000000 and is less than 0.05 (α). It is highly significant. For the demand of Analgesic p-value is 0.0000001 and is ...
http://aijournals.com/index.php/aan/article/view/978
Minimum analgesic concentration of bupivacaine after continuous epidural infusion following spinal anesthesia in the...Minimum analgesic concentration of bupivacaine after continuous epidural infusion following spinal anesthesia in the...
Case pain visual analog score persisted above 10 mm, patient was rejected and the same bupivacaines concentration was administered to the next patient.. Bupivacaines minimum analgesic concentration was calculated by Massey and Dixons formula 8.. Upper sensory block level and Bromage scores were compared between effective and ineffective concentrations by Mann-Whitney test. Significance level was established to 5%.. RESULTS. Demographics data of both samples are shown in table I.. Study I. Figure 1 shows the responses to different bupivacaine concentrations. Bupivacaines MAC-LA could not be calculated because data did not meet essential Massey and Dixon formulas requirements. There were 6 effective responses, 15 ineffective and 7 rejections. Mean bupivacaine concentration in this sample was 0.18% ±0.05%. Mean effective bupivacaine concentration was 0.19% ±0.07% and mean ineffective concentration was 0.18% ±0.055% (p,0.05). Median pain visual analog score (extremes) before bupivacaine ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942001000500003&lng=en&nrm=iso&tlng=en
A Comparison of Intrathecal Bupivacaine With Fentanyl to Bupivacaine Alone for Elective Caesarian Section MAHE Digital...A Comparison of Intrathecal Bupivacaine With Fentanyl to Bupivacaine Alone for Elective Caesarian Section MAHE Digital...
Background-This study was designed to evaluate effect of adding 25 μg of fentanyl to 0.5% intrathecal bupivacaine for elective caesarean section. Methods- The study was conducted on 40 ASA I & II women posted for elective caesarean section. Patients were randomized into two groups and lumbar subarachnoid block performed with bupivacaine and fentanyl, or bupivacaine alone. The time of onset , upper level of block, duration of sensory and motor block, systolic blood pressure, heart rate and respiratory rate were recorded and analysed. Results- It was observed that fall in blood pressure and sedation showed significant differences between the groups. None of the other variables differed. Conclusion- Addition of fentanyl to bupivacaine resulted in faster onset of action and effective spinal anaesthesia with a lower dose of bupivacaine. The duration of block was similar in both groups. The most striking feature was the greater hemodynamic stability with the addition of fentanyl.. ...
http://eprints.manipal.edu/136682/
A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...
TY - JOUR. T1 - A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of pain following laparoscopy and dye. AU - Sripada, Sreebala. AU - Roy, S.. AU - Mathur, M.. AU - Hamilton, M. AU - Cranfield, K.. AU - Bhattacharya, Siladitya. PY - 2006. Y1 - 2006. N2 - The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. Women received either 15 ml of 0.9% saline (n=42) or 15 ml of 0.5% bupivacaine (n=43), which was instilled intraperitoneally. Pain and nausea scores were recorded on a visual analogue scale (VAS). Pain perception was no different in the bupivacaine group compared with the control group with median values of VAS at 2 hours (18, 19; P=0.8), 6 hours (21, 22; P=0.5), 12 hours (19, 25; P=0.8), 24 hours (27, 27; P=0.9) and 48 hours (21, 13; P=0.26). Women in the bupivacaine group were less ...
https://abdn.pure.elsevier.com/en/publications/a-prospective-double-blind-randomised-controlled-trial-of-intraop
Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor - Full Text View - ClinicalTrials.govEffects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor - Full Text View - ClinicalTrials.gov
The aim of this study is to measure the effects of bupivacaine administered via epidural catheters on indices of motor blockade ascertained during the second stage of labor. This is a randomized, double-blind, controlled trial designed to address the primary research question: Does bupivacaine lengthen the second stage of labor? The secondary research question is: Is there other evidence of motor blockade attributable to bupivacaine during the second stage of labor?. The investigators know from prior studies that the length of the second stage in nulliparous women delivered at Parkland Hospital without epidural analgesia is 28 minutes. The investigators hypothesize in this now proposed study that epidural analgesia with bupivacaine will significantly increase this baseline from 28 minutes to 37 minutes or more (a 33% increase) thus implicating motor blockade. Baseline data for the Bromage and Breen scores during the second stage as well as the uterine contractility data are not available as ...
https://clinicaltrials.gov/ct2/show/NCT01621230
Continuous infusion bupivacaine via an elastomeric pumpContinuous infusion bupivacaine via an elastomeric pump
METHODS: A retrospective cohort study was conducted to evaluate patient outcomes following liposomal bupivacaine and elastomeric bupivacaine pump use from January through June 2013. The primary objective of the study was to evaluate 24-hour postoperative opioid use (in morphine equivalents).. RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included. Significant between-group differences were seen in American Society of Anesthesiologists physical status, patient-controlled analgesia use, postoperative nonopioid use, and surgical procedure. On univariate analysis, liposomal bupivacaine-in comparison with elastomeric bupivacaine pump -was associated with reduced median (interquartile range, IQR) 24-hour postoperative opioid use (33.0 mg morphine equivalents [IQR, 19.0-80.4 mg morphine equivalents] versus 70.4 mg morphine equivalents [IQR, 37.1-115.4 mg morphine equivalents], p , 0.001) and median 72-hour postoperative opioid use (61.3 mg morphine ...
http://www.ivteam.com/intravenous-literature/continuous-infusion-bupivacaine-via-an-elastomeric-pump/
Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine,...Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine,...
Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine, bupivacaine plus clonidine and bupivacaine plus dexmedetomidine in spinal anesthesia: prospective, comparative study
https://www.msjonline.org/index.php/ijrms/article/view/4527
Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...
The aim of this study was to determine the onset and offset of antinociception after sciatic (ScN) and femoral (FN) nerve blocks. Six healthy adult cats (4.8±1.3years; 4.3±0.4 kg) were included in a randomised, crossover, blinded and controlled study. Following sedation with dexmedetomidine (25 µg/kg, intramuscular), each ScN and FN injection was performed using 0.1 ml/kg of saline (CONTROL), bupivacaine (0.46 per cent, 0.46 mg/kg; BUPI), bupivacaine and dexmedetomidine (1 µg/kg; BUPI-DEX) or bupivacaine and buprenorphine (2.5 µg/kg; BUPI-BUPRE). Atipamezole (250 µg/kg) was administered after injections. Paw withdrawal thresholds (PWT) and motor blockade were evaluated before sedation and up to 24 hours. The PWT were significantly increased at half an hour in CONTROL, from two to four hours in BUPI and BUPI-DEX when compared with baseline. Motor blockade was observed between one and three hours in treatments using bupivacaine. Ability to walk was significantly impaired in BUPI at half an ...
https://veterinaryrecord.bmj.com/content/180/24/592
Bupivacaine Injection of Eye Muscles to Treat Strabismus - Full Text View - ClinicalTrials.govBupivacaine Injection of Eye Muscles to Treat Strabismus - Full Text View - ClinicalTrials.gov
Patients eligible for inclusion in the study will be age 8 to 95 years and have an eye deviation (strabismus) that is potentially subject to surgical correction.. The eye alignment will be measured. The eye muscles will be measured by MRI. The eye will be anesthetized by eye drops. One or more eye muscles will be injected with bupivacaine. Botox® will be injected into the antagonist muscle in some cases to increase the effect of the bupivacaine.. Data on the strabismus deviation, any side effects of the drug injection, and the eye muscles as measured by MRI, will be recorded at intervals after injection. These data will be compared with the like measurements taken before injection.. The primary outcome will be the eye alignment change at 180 days. A secondary outcome will be the change in muscle size, strength, or stiffness.. For large strabismus deviations not fully corrected by a first injection, a second injection can be made. Follow-up alignment and muscle measurements will be as for the ...
https://clinicaltrials.gov/ct2/show/NCT01616108?recr=Open&cond=%22Strabismus%22&rank=1
Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...
Introduction: Continuous research were undertaken in past to see the effect of anesthetic agent with adjuvant agents to increase their effect. The addition of adjuvant substances as clonidine, Dexmedetomidine, tramadol, midazolam, opioids, adenosine, to the local anesthetic drugs in TAPB and their efficiency have been studied. Hence the aim of the present study was to check the effect of Bupivacaine alone and Bupivicaine plus Dexamethasone in hernia block.Material & Methods: The total of 60 patients with age range from 30 to 60 years was included in the study. All the 60 patients were divided in to two groups, with 30 patients in each group. Group 1 consisted of 30 patients were administered with 20 ml of 0.5% bupivacaine in a TAP block performed at the same side of surgery to be performed. Group II consisted of 30 patients; were administered with 20 ml of 0.5% bupivicaine with 2 ml of dexamethasone in a TAP block performed at the same side of surgery.Results: In the present study, the duration of
https://www.ommegaonline.org/article-details/Comparative-Study-of-Hernia-Block-with-Bupivacaine-Alone-and-Bupivacaine-Plus-Dexamethasone-as-Adjuvant-for-Open-Hernia-Repair-at-Day-Care-Unit/1571
Bupivacaine Hydrochloride 0.5%w/v solution for Injection (glass ampoules) - Summary of Product Characteristics (SmPC) - print...Bupivacaine Hydrochloride 0.5%w/v solution for Injection (glass ampoules) - Summary of Product Characteristics (SmPC) - print...
Bupivacaine Hydrochloride 0.5%w/v solution for Injection (glass ampoules) - Summary of Product Characteristics (SmPC) by ADVANZ Pharma - print friendly
https://www.medicines.org.uk/emc/product/5763/smpc/print
Bupivacaine hydrochloride,monohydrate,usp - Alfa ChemistryBupivacaine hydrochloride,monohydrate,usp - Alfa Chemistry
Bupivacaine hydrochloride,monohydrate,usp/ACM73360540 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
http://www.alfa-chemistry.com/cas_73360-54-0.htm
99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik
kualitas obat anestesi lokal produsen & eksportir - Beli 99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik dari Cina produsen.
http://indonesian.peptidesteroids.com/sale-10233088-99-purity-bupivacaine-hydrochloride-cas-14252-80-3-for-analgesic.html
Levobupivacaine - WikipediaLevobupivacaine - Wikipedia
Levobupivacaine (rINN) /liːvoʊbjuːˈpɪvəkeɪn/ is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine. Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time. Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children. Levobupivacaine is contraindicated for IV regional anaesthesia (IVRA). Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur. Systemic exposure to ...
https://en.wikipedia.org/wiki/Levobupivacaine
Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | CirculationStereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Determination of whether bupivacaine enantiomers block Na+ channels differently in the rested, activated, and inactivated channel states may result in a better understanding of their cardiodepressant effects. In the present study, both enantiomers of bupivacaine induced very limited tonic block measured as the reduction of INa amplitude during the first pulse after a long rest period. The amount of block measured from the reduction of peak current reflects both the rested-state block and the activated (open)-state interaction between the Na+ channel and the drug that develops during the depolarizing step before reaching peak current.18 Although tonic block is not necessarily an accurate measure of drug binding to rested Na+ channels, the observed low level indicates that both enantiomers must exhibit a low affinity for the rested state of the Na+ channel. Moreover, the interaction of bupivacaine enantiomers with the rested state of the Na+ channel was not stereoselective. Similar results were ...
http://circ.ahajournals.org/content/92/10/3014
Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin CellsEffect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
On the Convergence of Bio-, Information-, Enrivonmental-, Energy-, Space- and Nano-Technolgies: Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
https://www.scientific.net/KEM.277-279.56
Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2
HPLC Application #17309: Bupivacaine on Lux Cellulose-2. Column used: Lux® 5 µm Cellulose-2, LC Column 250 x 4.6 mm, Ea Part#: 00G-4457-E0
http://www.phenomenex.com/Application/Detail/17309
Journal of Anaesthesiology Clinical PharmacologyJournal of Anaesthesiology Clinical Pharmacology
RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to its Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy ...
https://joacp.org/showstats.asp?issn=0970-9185
HTX-011 | Heron TherapeuticsHTX-011 | Heron Therapeutics
HTX-011, which utilizes our proprietary Biochronomer® drug delivery technology, is under investigation in Phase 3 clinical studies as a long-acting formulation of the local anesthetic bupivacaine in a fixed-dose combination with the anti-inflammatory meloxicam for the prevention of post-operative pain. By delivering sustained levels of both a potent anesthetic and an anti-inflammatory agent directly to the site of tissue injury, HTX-011 was designed to deliver superior pain relief while potentially reducing the need for systemically administered pain medications such as opioids, which carry the risks of harmful side effects, abuse, and addiction.. HTX-011 is the first long-acting anesthetic that is designed to address both post-operative pain and accompanying inflammation by combining the local anesthetic bupivacaine and the anti-inflammatory meloxicam in a single administration. Targeting both pain and inflammation has allowed HTX-011 to demonstrate an advantage over current standard of care ...
http://www.herontx.com/HTX-011
Aging | Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress - Figure
Manganese superoxide dismutase (SOD2) is a key enzyme to scavenge free radical superoxide in the mitochondrion. SOD2 deficiency leads to oxidative injury in cells. Bupivacaine, a local anesthetic commonly used in clinic, could induce neurotoxic injury via oxidative stress. The role and the mechanism of SOD2 regulation in bupivacaine-induced oxidative stress remains unclear. Here, bupivacaine was used to treat Sprague-Dawley rats with intrathecal injection and culture human neuroblastoma cells for developing vivo injury model and vitro injury model. The results showed that bupivacaine caused the over-production of mitochondrial reactive oxygen species (mtROS), the activation of C-Jun N-terminal kinase (JNK), and the elevation of SOD2 transcription. Decrease of mtROS with N-acetyl-L-cysteine attenuated the activation of JNK and the increase of SOD2 transcription. Inhibition of JNK signaling with a small interfering RNA (siRNA) or with sp600125 down-regulated the increase of SOD2 transcription. SOD2 gene
https://www.aging-us.com/figure/103447/f6
Cook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited StoreCook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited Store
0.5 Bupivacaine HCl with 1:200,000 epinephrine bitartrate. Specifically effective in lengthy dental procedures for which more than 90 minutes of pulpal anesthesia is necessary, or for the management of post-operative pain. Marcaine ® is the original bupivacaine in the dental world and is part of the complete line of Cook-Waite products the brand dental professionals have relied on for more than 60 years. Each box contains 50 x 1.7mL cartridges.. MSDS. Product Brochure. ...
http://www.hansamed.net/pain-management/cook-waite-marcaine-0-5-with-epinephrine-1-200-000-bupivacaine-50-1-7ml-carpules-box/
Search Results | Anesthesiology | American Society of Anesthesiologists
Background Ropivacaine is a new amide local anesthetic, having therapeutic properties similar to those of bupivacaine but with a wider margin of safety. Bupivacaine is probably the most commonly used drug in obstetric epidural analgesia, even though laboratory studies have suggested that pregnancy increases the cardiotoxicity of bupivacaine but not of other local anesthetics. The current study was designed to reevaluate, in a random and blinded fashion, the systemic toxicity of bupivacaine and ropivacaine in nonpregnant and pregnant sheep. Methods Chronically prepared nonpregnant and pregnant ewes were randomized to receive an intravenous infusion of ropivacaine or bupivacaine at a constant rate of 0.5 mg.kg-1.min-1 until circulatory collapse. The investigators were blinded to the identity of local anesthetic. Heart rate, arterial blood pressure, and cardiac rhythm were monitored throughout the study. Arterial blood samples were obtained before infusion and at the onset of toxic manifestations, ...
https://asa2.silverchair.com/anesthesiology/search-results?f_AllAuthors=Hisayo%C2%A0O.+Morishima
Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...
Abstract of Paper: Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine in Caudal Analgesia after Lower Abdominal Surgery in Pediatrics , Author: Omar Mohey Eldin A. El-Maksoud MD, Ehab El -Shebat Afifi MD, Ahmed Mostafa A. El-Hamid MD and Ahmed A. Mosaad M.Sc , Year: 2012 , Faculty of Medicine, Benha University
http://bu.edu.eg/medicine_publications/721/abstract
Bupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiBupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Bupivacaine - Get up-to-date information on Bupivacaine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Bupivacaine
https://www.rxwiki.com/bupivacaine
Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response...
Twenty patients undergoing elective cholecystectomy were prospectively randomised to receive either intrapleural (bolus 20 ml followed by 10 ml/h) or thoracic epidural (bolus 9 ml followed by 5 ml/h) bupivacaine 0.5% for 8 h postoperatively to assess the effect of these two techniques on pain, pulmonary function and the surgical stress response. As assessed by the visual analogue scale (VAS), both groups received good but not total pain relief. Both groups had a 50% reduction in forced expiratory volume (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEFR) after operation, and there was no observed effect on the stress response as measured by plasma glucose and cortisol. It is concluded that while both techniques provide good analgesia, the degree and extent of nerve blockade are not sufficient to affect the afferent neurogenic stimuli responsible for the observed effects on pulmonary function and the stress response ...
https://research.regionh.dk/da/publications/comparison-of-the-effects-of-continuous-intrapleural-vs-epidural-administration-of-05-bupivacaine-on-pain-metabolic-response-and-pulmonary-function-following-cholecystectomy
Episode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC PodcastEpisode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC Podcast
Great question. Here is Dr. Rayazs response:. You calculate the number of milligrams for both local anesthetics and then use the max dose that is the lower of the two local anesthetics. For example, if you give 100mg plain lidocaine without epinephrine (max dose of 4.5-5mg/kg depending on the source) and then intend on giving bupivacaine (max dose of 2.5mg/kg) for a 100kg patient, then you would do the following calculation:. Use the max dose for bupivacaine since it is the lower max dose of the two local anesthetics being used.. 2.5mg/kg x 100kg = 250mg. 250mg - 100mg = 150mg. That leaves 150mg of bupivacaine that can be used or about 60cc of 0.25% bupivacaine (150mg/2.5mg/kg) left over for a tap block.. For a 70kg patient:. 2.5mg/kg x 70kg = 175mg. 175mg - 100mg = 75mg. That leaves 75mg of bupivacaine for a tap block or 30cc of 0.25% bupivacaine (75mg/2.5mg/kg) or 15cc of 0.5% bupivacaine (75mg/5mg/kg). Its a bit more simple in practice than the math problems make it seem. In general, ...
http://accrac.com/episode-147-lower-extremity-nerve-blocks-part-2-front-of-leg/
FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists - The...
Particulate matter found in solution, glass vial. The US Food and Drug Administration (FDA) has alerted health care professionals that Hospira, Inc (Lake Forest, IL) has announced a voluntary nationwide recall to the user level for 1 lot of 0.5% Marcaine (bupivacaine HCl injection, USP), 30 mL, single-dose vial - preservative free (NDC 0409-1560-29), lot 33-545-DD.. The recall is due to a confirmed customer report of particulate embedded in the glass vial as well as visible particulate in the solution. Hospira has attributed the embedded particulate to a suppliers glass defect, and is working with its supplier on implementing corrective and preventive actions.. According to Hospira, the recalled lot of Marcaine was distributed November 2013 through March 2014 to wholesalers/distributors, hospitals, and clinics across the United States.. If you have any inventory of the recalled product, you are advised to immediately stop use and quarantine it. Please also inform potential users of this product ...
http://www.asrs.org/advocacy-practice/updates/293/
Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: Inversion of postoperative pain relief efficacy. |...Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: Inversion of postoperative pain relief efficacy. |...
The number of ambulatory surgical procedures is growing and local anesthesia represents the technique of choice for outpatients undergoing minor surgery. The aim of this study was to verify whether differences exist in postoperative pain relief using equipotent doses of two long-acting local anesthetics, ropivacaine and levobupivacaine, in patients who underwent minor breast surgery. A series of 86 consecutive women (median age=55, range=39-75 years) with small (,2 cm in size) breast masses requiring surgical excision were prospectively enrolled in the study. Patients were randomly selected to receive 75 mg/ml ropivacaine (group A, 42 patients) or 5 mg/ml levobupivacaine (group B, 44 patient). For post-surgical measurement of pain intensity a visual analog scale (VAS) was used. The age of the patients (56.4±9.6 vs. 56.7 ±9.5 years; p=0.88) and operative time (38.4 ± vs. 39.8 ±5.0 min; p=0.16), did not differ significantly between the groups (A vs. B). Transient adverse effects were observed ...
https://www.research.unipd.it/handle/11577/2537096
Combined Spinal and General Anesthesia Attenuates Liver Metastasis by Preserving Th1/Th2 Cytokine Balance | Anesthesiology |...Combined Spinal and General Anesthesia Attenuates Liver Metastasis by Preserving Th1/Th2 Cytokine Balance | Anesthesiology |...
To evaluate the analgesic effect of spinal block and systemic morphine, we conducted a preliminary experiment. Analgesia was evaluated by the tail-flick (TF) test. The light beam from a projector bulb was focused on the middle portion of the tail to produce a spot of intense heat, and the TF latency was measured. The intensity of the thermal stimulus was adjusted so that the baseline TF latency was 1.0-2.5 s. A 10-s cutoff time was imposed to minimize tissue damage. In all experiments, the TF latency was determined three times for each mouse. Measurements were obtained before intervention and at 10, 30, 60, 120, 180, 240, 300, and 360 min after awaking from anesthesia. We tested five regimens of spinal block (25 μg bupivacaine alone, 25 μg bupivacaine plus 0.5 μg morphine, 25 μg bupivacaine plus 1.25 μg morphine, 25 μg bupivacaine plus 2.5 μg morphine, and 25 μg bupivacaine plus 5 μg morphine) and systemic injection of morphine (5 mg/kg intraperitoneally23). We also tested two control ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1922805
A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...
Materials and Methods: This was a prospective study carried out in department of obstetrics and gynaecology in Rajah muthiah Medical College and Hospital from 2015-2017 after ethical clearance and written knowledgeable concent. A total of 100 parturients in both latent and active phase of labour were to receive an epidural injection of 12 ml of bupivacaine 0.125% as initial bolus dose. Same dose regimen was used as subsequent top-up dose on patients demand for pain relief. The duration and quality of analgesia, motor block, top-up doses required consumption of bupivacaine and feto-maternal outcome were observed ...
http://journalijcmes.com/issues/clinical-study-labour-using-epidural-analgesia-0125-bupivacaine-and-its-outcome
Brazilian Journal of Anesthesiology - Volume 59 / Issue 3Brazilian Journal of Anesthesiology - Volume 59 / Issue 3
Rev. Bras. Anestesiol., vol.59 n3, 261-272, 2009 Epidural block for cesarean section: a comparative study between 0.5% racemic Bupivacaine (S50-R50) and 0.5% enantiomeric excess Bupivacaine (S75-R25) associated with Sufentanil Angélica de Fátima de Assunção Braga; José Aristeu F. Frias; Franklin Sarmento da Silva Braga; Rosa Inês Costa Pereira; Mayla F Blumer; Marcia F Ferreira Scientific Article ...
https://bjan-sba.org/ed/5dd67d6a0e8825dc29c8fca7
Bupivacaine-induced myocardial depression and pulmonary edema:...Bupivacaine-induced myocardial depression and pulmonary edema:...
Bupivacaine-induced myocardial depression and pulmonary edema: a case report.: Central nervous system and cardiovascular toxicity are well-known side effects of
https://www.mysciencework.com/publication/show/bupivacaine-induced-myocardial-depression-pulmonary-edema-case-report-b611e49c
Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.
The pharmacokinetics of lidocaine and bupivacaine and tri-deuteromethyl-labelled lidocaine and bupivacaine were investigated in healthy volunteers. The deuterium-labelled and the unlabelled form of the drug to be investigated were simultaneously infu
http://www.biomedsearch.com/nih/Pharmacokinetics-lidocaine-bupivacaine-stable-isotope/3342287.html
Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
We aimed to investigate the efficacy of either plain or hyperbaric solutions of intrathecal bupivacaine and ropivacaine on maternal block characteristics, complications, side effects and neonatal parameters to find out which is superior in a single s
http://www.biomedsearch.com/nih/Intrathecal-hyperbaric-isobaric-bupivacaine-ropivacaine/20230319.html
Bupivacaine implant - Innocoll - AdisInsightBupivacaine implant - Innocoll - AdisInsight
Innocoll (a subsidiary of Gurnet Point Capital) is developing a bupivacaine implant formulation for the treatment of postoperative pain. Bupivacaine is a local
http://adisinsight.springer.com/drugs/800025886?error=cookies_not_supported&code=1bf7e760-1303-44a5-bdb6-13cae69f8e3d
Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...
Both PKA and PKC contribute to the activation of ERK in dorsal horn neurons. Kawasaki et al. 10 reported that there were additive effects of PKA and PKC on ERK activation, indicating that PKA and PKC are independent pathways to activate ERK in dorsal horn neurons. Forskolin, acting as a classic stimulator of adenylyl cyclase,34 can increase cAMP, activating PKA, and thus coupling to ERK through the Raf/Ras pathway. Although bupivacaine had no effects on pERK induced by nociceptor-associated GPCR agonists, which might also act through Ras/Raf, bupivacaine still reduced forskolin-induced pERK. Several studies have demonstrated, however, that forskolin has diverse sites of action including not only adenylyl cyclase, but also the glucose transporter and ligand- and voltage-gated ion channels.35 Forskolin modulates voltage-dependent K+conductance through cAMP-dependent and cAMP-independent mechanisms,35 inhibiting voltage-dependent K+channels in Helix neurons,36 nudibranch neurons,18 and PC12 cells37 ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923305
Bupivacaine & Adrenaline 0.5% - Drugs.comBupivacaine & Adrenaline 0.5% - Drugs.com
Bupivacaine & Adrenaline 0.5% is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bupivacaine & Adrenaline 0.5% is available on the Drugs.com website.
https://www.drugs.com/international/bupivacaine-adrenaline-0-5.html
Update on the clinical utility and practical use of ropivacaine in Chi | DDDTUpdate on the clinical utility and practical use of ropivacaine in Chi | DDDT
Update on the clinical utility and practical use of ropivacaine in Chinese patients Man Li, Li Wan, Wei Mei, Yuke Tian Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China Abstract: We reviewed the Chinese and English literature for efficacy and tolerability data as well as pharmacological properties of ropivacaine in Chinese patients. Ropivacaine is a long-acting amide local anesthetic agent that elicits nerve block via reversible inhibition of sodium ion influx in nerve fibers. The available evidence in the literature on anesthesia practice indicates that ropivacaine produces equally surgical sensory block and postoperative and obstetrics analgesia with good maternal and fetal outcome to those of bupivacaine or levobupivacaine. It appears to be associated with comparable onset, quality, and duration of sensory block, but with a lower incidence or grade of motor block, compared to bupivacaine. The
https://www.dovepress.com/update-on-the-clinical-utility-and-practical-use-of-ropivacaine-in-chi-peer-reviewed-article-DDDT
June 21, 2020 - Food & Beverage HeraldJune 21, 2020 - Food & Beverage Herald
Levobupivacaine is a long-acting local anesthetic agent belonging to the amido amine group, it is basically an S-enantiomer of bupivacaine drug. It has become popular among anesthesiologists worldwide owing to its less cardiotoxicity and motor blockade. It was primarily developed due to the reported incidents of seizures and cardiac arrests experienced due to the use of intravenous injection of bupivacaine. Significant rise in surgeries performed and increasing demand for post-operative pain management drive the levobupivacaine market growth. Epidural anesthesia is currently representing the largest market share in the levobupivacaine market.…. Read More ...
https://fnbherald.com/2020/06/21/
Sabinet | Clinical trial: Bupivicaine hydrochloride in the treatment of sports injuriesSabinet | Clinical trial: Bupivicaine hydrochloride in the treatment of sports injuries
Bupivicaine hydrochloride is a long-acting local anaesthetic. Its use results in local anaesthesia lasting between 12-24 hours. The drug has been extensively used in thoracic and abdominal surgery and as caudal analgesia in obstetrics. It has also been used in nerve blocks.
http://journals.co.za/content/m_sajsm/6/1/AJA10155163_801
Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLinkComparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLink
We conducted a retrospective study to determine whether bupivacaine or fentanyl is a better adjuvant to epidural morphine for postoperative analgesia using 108 patients. Following epidural lidocaine...
https://link.springer.com/article/10.1007/BF02514703
Buffered bupivacaine : Hulu ip address
Sequence Analysis BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) BLAST Link (BLink) Conserved Domain Search Service (CD Search) Genome ProtMap Genome Workbench Influenza Virus Primer-BLAST ProSplign Splign All Sequence Analysis Resources.There is concern regarding neurotoxicity induced by the use of local anesthetics.The effect of pH buffering on reducing the pain associated with subcutaneous infiltration of bupivicaine.Lidocaine buffered with bicarb combination of lidocaine and bupivacaine,.The time taken to find the LA with epi with right concentration and working out the final combination dose is longer than the time to wait for the LA with epi (given straight) to work ...
http://99online.us/pujox/buffered-bupivacaine-511.php
Postoperative - ESRAPostoperative - ESRA
A study comparing thoracic epidural bupivacaine with and without opioid to a continuous paravertebral infusion of bupivacaine showed that analgesia on all postoperative days was superior in the thoracic epidural group receiving bupivacaine plus hydromorphone, but was similar in the epidural and continuous paravertebral groups receiving bupivacaine alone (Grider et al. 2012, n=75, LoE 1 ...
https://esraeurope.org/prospect/procedures/thoracotomy-2015/postoperative-8/
Anesthetics, Local - CatalogAnesthetics, Local - Catalog
Bupivacaine; Anekain; Bloqueina; Bupivacaina [INN-Spanish]; Bupivacaine HCL; Bupivacaine HCL KIT; Bupivacainum [INN-Latin]; Bupivacine HCL Preservative Free; Bupivan; Carbostesin; Chirocaine; DL-Bupivacaine; LAC-43; Marcaina; Marcaine; Marcaine HCL; Marcaine Spinal; Sensorcaine; Sensorcaine Forte; Sensorcaine-MPF; Sensorcaine-MPF Spinal; ...
https://pharmacycode.com/catalog-Anesthetics%2C_Local.html
The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...
Multimodal analgesia following total hip arthroplasty has been shown to improve patient satisfaction, participation with physical therapy, and allow early return to self care. Liposomal bupivacaine is a formulation of local anesthetic which has the potential to provide anesthesia for up to 72 hours following administration. The purpose of this study was to compare the effectiveness of liposomal bupivacaine with bupivacaine following total hip arthroplasty. A retrospective chart review was performed on 28 patients undergoing total hip arthroplasty or hip resurfacing who received intraoperative administration of liposomal bupivacaine. A control group of 30 patients who had previously undergone total hip arthroplasty or hip resurfacing and had received intraoperative administration of bupivacaine also underwent a chart review. Length of stay, post-operative opioid use, and pain scores were compared for both groups. The average length of stay in the study group was 1.93 days and the control group length of
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-15-310/figures/1
Influence of Voltage-sensitive Ca++Channel Drugs on Bupivacaine Infiltration Anesthesia in Mice | Anesthesiology | American...Influence of Voltage-sensitive Ca++Channel Drugs on Bupivacaine Infiltration Anesthesia in Mice | Anesthesiology | American...
Finally, the role of T-, P-, and Q-type channels in modulating sensory transduction at the level of nociceptors in skin remains to be investigated further. In our hands, the T-type Ca++channel blocker flunarizine failed to modulate bupivacaine anesthesia. In fact, flunarizine was inactive alone, and all three concentrations failed to affect the ED50value for bupivacaine (data not shown). Flunarizine has been reported to block Na+and L-type Ca++channels. Yet flunarizine did not enhance bupivacaine like the 1,4-dihydropyridines or elicit anesthesia like verapamil. Instead, the results indicate that T-type channels, if present on nociceptors, do not modulate bupivacaine anesthesia to noxious radiant heat. Infiltration of the P-type Ca++channel blocker ω-agatoxin IVA (0.063-0.48 μm) in the tail also failed to affect bupivacaine anesthesia. Yet several studies reported that P-type channels in the spinal cord block nociceptive input. Intrathecal ω-agatoxin IVA blocked formalin-induced nociception ...
https://pubs.asahq.org/anesthesiology/article/95/5/1189/39206/Influence-of-Voltage-sensitive-Ca-Channel-Drugs-on
Effects of extradural bupivacaine with adrenaline for caesarean section on uteroplacental and fetal circulation<...Effects of extradural bupivacaine with adrenaline for caesarean section on uteroplacental and fetal circulation<...
TY - JOUR. T1 - Effects of extradural bupivacaine with adrenaline for caesarean section on uteroplacental and fetal circulation. AU - Alahuhta, S.. AU - Räsänen, J.. AU - Jouppila, R.. AU - Jouppila, P.. AU - Hollmén, A. I.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1991/12. Y1 - 1991/12. N2 - We have studied the effects of an extradural block using bupivacaine with adrenaline 90-100 μg on blood flow in the maternal uterine and placental arcuate arteries and the fetal umbilical, renal and middle cerebral arteries, using a colour Doppler technique in eight healthy parturients undergoing elective Caesarean section. Fetal myocardial function was investigated simultaneously by M-mode echocardiography. Maternal heart rate increased and diastolic arterial pressure decreased after extradural administration of bupivacaine with adrenaline. The latter effect was relieved by increasing the infusion rate in every case and none of the patients required vaso-pressors. There ...
https://ohsu.pure.elsevier.com/en/publications/effects-of-extradural-bupivacaine-with-adrenaline-for-caesarean-s-2
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial | American Journal of...Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial | American Journal of...
BACKGROUND: Moderate to severe pain associated with the removal of pleural chest tubes is poorly controlled with opioids. New methods are needed to manage the pain associated with this procedure. OBJECTIVES: To compare the effects of interpleural injections of 0.25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients. METHODS: A randomized, double-blind, placebo-controlled trial was used, with a repeated measures design. Pain intensity and distress were measured before, immediately after, and 1 hour after chest tube removal. Pain sensations and affect were evaluated immediately after chest tube removal. The experimental group (n = 21) received bupivacaine and the control group (n = 20) received normal saline. RESULTS: In both groups pain intensity and distress scores were significantly higher at the time of chest tube removal than immediately before or 1 hour after. No significant differences in pain intensity, distress, ...
https://aacnjournals.org/ajcconline/article-abstract/5/2/102/6136/Effects-of-interpleural-bupivacaine-on-pleural?redirectedFrom=fulltext
Ropivacaine - WikipediaRopivacaine - Wikipedia
Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur. Systemic exposure to excessive quantities of ropivacaine mainly result in central nervous system (CNS) and cardiovascular effects - CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures followed by depression (drowsiness, loss of consciousness), respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest - some of which may be due to hypoxemia secondary to respiratory depression.[2] ...
https://en.wikipedia.org/wiki/Ropivacaine
Tramadol as adjunct to psoas compartment block with levobupivacaine 0.5%: a randomized double-blinded study.
BACKGROUND: Tramadol has been administered peripherally to prolong analgesia after brachial plexus and neuraxial blocks. Our aim was to evaluate the systemic and perineural effects of tramadol as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. METHODS: In a randomized, prospective, double-blinded trial, 60 patients (ASA I-III), aged 49-88 yr, undergoing primary total hip or knee arthroplasty underwent PCB and subsequent bupivacaine spinal anaesthesia. Patients were randomized into three groups. Each patient received PCB with levobupivacaine 0.5%, 0.4 ml kg(-1). The control group (group L, n=21) received i.v. saline, the systemic tramadol group (group IT, n=19) received i.v. tramadol 1.5 mg kg(-1) and the perineural tramadol group (group T, n=20) received i.v. saline and PCB with tramadol 1.5 mg kg(-1). Postoperatively patients received regular paracetamol 6-hourly and diclofenac sodium 12-hourly. Time to first morphine analgesia, 24-hour morphine consumption, sensory ...
https://www.lenus.ie/handle/10147/208935
Bupivacaine Hcl Introduction | acridinekBupivacaine Hcl Introduction | acridinek
Bupivacaine Hcl is accessible in concentrations of 0.25, 0.5, and 0.75% (2.5, 5, and 7.5 mg/mL, respectively) in single-dose containers. The 0.25 and 0.5% concentrations aswell appear in 50-mL multiple-dose vials with methylparaben 1 mg/mL as a preservative. Sodium hydroxide or hydrochloric acerbic is acclimated to acclimatize the pH. Bupivacaine Hcl is aswell accessible in…
https://acridinek.wordpress.com/2014/06/16/bupivacaine-hcl-introduction/
Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine...Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine...
The effectiveness of a combination of a lipid emulsion with epinephrine in reversing local anesthetic-induced cardiac arrest has been confirmed. The combination of a lipid emulsion with levosimendan, was shown to be superior to administration of a lipid emulsion alone with regard to successful resuscitation. In this study, we compared the reversal effects of levosimendan, epinephrine, and a combination of the two agents in lipid-based resuscitation in a rat model of bupivacaine-induced cardiac arrest. Fifty-four adult male Sprague-Dawley rats were subjected to bupivacaine (15 mg·kg−1) -induced asystole and were then randomly divided into 3 groups. A lipid emulsion was used as the basic treatment, and administration of drug combinations varied in each group as follows: (1) levosimendan combined with epinephrine (LiEL); (2) epinephrine (LiE); and (3) levosimendan (LiL). The resuscitation outcomes were recorded and included the rate of return of spontaneous circulation (ROSC) and survival at 40 min,
https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-017-0414-3/tables/1
Local Anesthetics Are Off-Label For Spinals | RK.mdLocal Anesthetics Are Off-Label For Spinals | RK.md
Note the lack of local anesthetics on that list. Lidocaine? No. Hyperbaric bupivacaine? No. Good ol tetracaine? Nope. All local anesthetics in the intrathecal space are off-label. Yet these are the very drugs that serve as the cornerstone for spinal anesthesia.. With a spinal needle and a few milliliters of local anesthetic like bupivacaine or lidocaine, we can achieve an anesthetic which enables surgeons to operate on the abdomen or lower extremities pain-free without any significant cardiopulmonary drawbacks. Sure, sympathectomies are a concern, but weve become extremely good at predicting and mitigating the effects of hypotension, tachy/bradycardias, etc ...
https://rk.md/2016/local-anesthetics-off-label-spinals/
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry -...
The final dataset included 38 subjects, 26 in the bupivacaine group and 12 in the saline group. A repeated measures analysis of variance showed that subjects receiving treatment with bupivacaine experienced a significant reduction in the numeric rating scale scores compared with those receiving saline at baseline (M = 3.78 vs M = 3.18, P = .10), 15 minutes (M = 3.51 vs M = 2.53, P , .001), 30 minutes (M = 3.45 vs M = 2.41, P , .001), and 24 hours after treatment (M = 4.20 vs M = 2.85, P , .001), respectively. Headache Impact Test-6 scores were statistically significantly decreased in subjects receiving treatments with bupivacaine from before treatment to the final treatment (Mdiff = -4.52, P = .005), whereas no significant change was seen in the saline group (Mdiff = -1.50, P = .13). CONCLUSION: SPG blockade with bupivacaine delivered repetitively for 6 weeks with the Tx360® device demonstrates promise as an acute treatment of headache in some subjects with CM. Statistically significant ...
https://www.sphenopalatineganglionblocks.com/headache-migraine-fibromyalgia-and-tmj-treatment-with-sphenopalatine-ganglion-blocks-and-neuromuscular-dentistry/
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry - Sleep and...
The final dataset included 38 subjects, 26 in the bupivacaine group and 12 in the saline group. A repeated measures analysis of variance showed that subjects receiving treatment with bupivacaine experienced a significant reduction in the numeric rating scale scores compared with those receiving saline at baseline (M = 3.78 vs M = 3.18, P = .10), 15 minutes (M = 3.51 vs M = 2.53, P , .001), 30 minutes (M = 3.45 vs M = 2.41, P , .001), and 24 hours after treatment (M = 4.20 vs M = 2.85, P , .001), respectively. Headache Impact Test-6 scores were statistically significantly decreased in subjects receiving treatments with bupivacaine from before treatment to the final treatment (Mdiff = -4.52, P = .005), whereas no significant change was seen in the saline group (Mdiff = -1.50, P = .13). CONCLUSION: SPG blockade with bupivacaine delivered repetitively for 6 weeks with the Tx360® device demonstrates promise as an acute treatment of headache in some subjects with CM. Statistically significant ...
https://www.sleepandhealth.com/headache-migraine-fibromyalgia-and-tmj-treatment-with-sphenopalatine-ganglion-blocks-and-neuromuscular-dentistry/
Sphenopalatine Ganglion (SPG) Blocks | SPG Blocks | Chicago
Sphenopalatine Ganglion - SPG Blocks Chicago. SPG Blocks have a hundred-year history of safety and efficacy. Contact Dr. Ira L. Shapira today.
https://www.sphenopalatineganglionblocks.com/tag/headache-tmj/
Comparison of the Analgesic Duration of 0.5% Bupivacaine With 1:200,000 Epinephrine Versus 0.5% Ropivacaine Versus 1%...Comparison of the Analgesic Duration of 0.5% Bupivacaine With 1:200,000 Epinephrine Versus 0.5% Ropivacaine Versus 1%...
Sixty eligible patients scheduled for arthroscopic shoulder surgery were randomized (1:1:1) to receive US-ISB (5 mL) with 0.5% bupivacaine with 1:200,000 epinephrine, 0.5% ropivacaine, or 1% ropivacaine. All individuals were blinded including study participants, anesthesiologists, surgeons, research personnel, and statistician. All participants received a standardized general anesthetic and multimodal analgesia. The primary outcome was duration of analgesia defined as the time from the end of injection to the time that the patients reported a significant increase in pain (,3 numeric rating scale [NRS]) at the surgical site.. ...
http://anesthesiaexperts.com/uncategorized/comparison-analgesic-duration-0-5-bupivacaine-1200000-epinephrine-0-5-ropivacaine-1-ropivacaine-low-volume-ultrasound-guided-interscalene-brachial-plexus-block-2/
Blockade of Na+and K+Currents by Local Anesthetics in the Dorsal Horn Neurons of the Spinal Cord | Anesthesiology | American...Blockade of Na+and K+Currents by Local Anesthetics in the Dorsal Horn Neurons of the Spinal Cord | Anesthesiology | American...
In the following experiments, the use dependence of Na sup + current block by local anesthetics (i.e., phasic block) was studied. Na sup + currents were activated every second by voltage steps from -80 to -30 mV, first in control solution and then in the presence of local anesthetics. Control current and several consecutive currents recorded with 100-micro Meter bupivacaine are shown in Figure 4(A). The amplitudes of peak Na sup + currents as a function of pulse number for 0-(control solution), 3-, and 300-micro Meter bupivacaine (n = 8, 8, and 6, respectively) are given in Figure 4(B). Na sup + currents recorded in the presence of local anesthetic were normalized to first currents recorded in control solution. The strongest reduction in the amplitude was seen in the currents activated by the first two pulses (N1 and N2;Figure 4(B)). In the presence of 300-micro Meter bupivacaine, the Na sup + current activated by the second pulse was reduced by 40.0 +/- 4.9%(n = 6) compared with that activated ...
https://pubs.asahq.org/anesthesiology/article/88/1/172/36525/Blockade-of-Na-and-K-Currents-by-Local-Anesthetics
Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological...Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological...
Stream Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological Surgeons Journal Club from desktop or your mobile device
https://soundcloud.com/cnsneurosurgeon/bupivacaine-field-block-with-clonidine-for-postoperative-pain-control-in-posterior-spine-approaches
Comparison of Tramadol and Buprinorphine as an Adjuvent to Bupivacaine used in Supraclavicular brachial plexus block for upper...Comparison of Tramadol and Buprinorphine as an Adjuvent to Bupivacaine used in Supraclavicular brachial plexus block for upper...
Results: Onset of analgesia is fast with tramadol added to bupivacaine and time to achieve complete block without any increase in side- effects ...
http://journalijdr.com/comparison-tramadol-and-buprinorphine-adjuvent-bupivacaine-used-supraclavicular-brachial-plexus
Nonnarcotic Analgesics Archives - Page 2 of 52 - MPRNonnarcotic Analgesics Archives - Page 2 of 52 - MPR
Xaracoll® (bupivacaine HCl; Innocoll Pharmaceuticals Limited) implant is now available for acute postsurgical pain relief for up to 24 hours in adults following open inguinal hernia repair. Xaracoll is a bioresorbable collagen-matrix implant designed to deliver bupivacaine HCl to the surgical site. Each implant contains 100mg of bupivacaine HCl (equivalent to 88.8mg bupivacaine) and 75mg…. ...
https://www.empr.com/tag/nonnarcotic-analgesics/page/2/
Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using...Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using...
Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using mucopolysaccharide as chiral mobile phase additive
http://eurjchem.com/index.php/eurjchem/article/view/964/pdf_964
Is continuous perineural stump infusion of bupivacaine effective on acute and chronic postoperative stump pain? Could it reduce...Is continuous perineural stump infusion of bupivacaine effective on acute and chronic postoperative stump pain? Could it reduce...
Background. Chronic pain as the result of long-term peripheral arterial disease and critical limb ischemia is difficult to manage and needs a multidisciplinary approach (pharmacological, psychological and functional) especially when the patient undergoes a lower limb amputation. Amputees show high rates of acute postoperative pain and chronic phantom limb pain in which there are few satisfactory available treatments. Nevertheless, it has been suggested for many years that continuous regional infusion of local anesthetic during immediate postoperative period is an effective and safe way of reducing these complications, morphine consumption and opioids-related adverse effects. However, data is conflicting as to its efficacy for both short-and log-term outcomes. Objective. The purpose of this study is to investigate whether a continuous postoperative perineural infusion system with bupivacaine is effective in reduction of postoperative acute pain and morphine intake during the first 72 hours ...
https://dugi-doc.udg.edu/handle/10256/14186
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR...Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR...
This study aimed to test the hypothesis that levobupivacaine has anti-tumour effects on breast cancer cells. Colony formation and transwell assay were used to determine breast cancer cells proliferation. Flow Cytometry (annexin V and PI staining) was used to investigate breast cancer cells apoptosis. The effects of levobupivacaine on cellular signalling and molecular response were studied with Quantitative Polymerase Chain Reaction and western blot. Induction of apoptosis was confirmed by cell viability, morphological changes showed cell shrinkage, rounding, and detachments from plates. The results of the western blot and Quantitative Polymerase Chain Reaction indicated activation of active caspase-3 and inhibition of FOXO1. The results of the flow Cytometry confirmed that levobupivacaine inhibited breast cancer cell proliferation and enhanced apoptosis of breast cancer cells. Quantitative Polymerase Chain Reaction and Western blot analysis showed increased p21 and decreased cyclin D. Quantitative
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-05191-2
Effect on post Tonsillectomy pain control with IV and infiltrated dexamethasone and infiltrated bupivacaine: A Randomized...Effect on post Tonsillectomy pain control with IV and infiltrated dexamethasone and infiltrated bupivacaine: A Randomized...
Objectives: To evaluate the effect on post tonsillectomy pain control with IV and infiltrated dexamethasone and infiltrated bupivacaine.. Methodology: This randomized controlled trial study was conducted in the department of ENT and neck surgery of Holy Family hospital, Rawalpindi, over a period of one year from May 2019 to May 2020. A total of 140 pediatric patients were selected and were divided into four equal groups randomly by lottery method. Patients in all four groups had endotracheal intubation with general anesthesia. As premedication, all the patients received intravenous midazolam (1mg). Intravenous fentanyl (1.5mg/kg) and propofol (2.5 mg/kg) followed by endotracheal intubation facilitated with atracurium (0.5 mg/kg) were used as general anesthesia in all patients.. Results: There was no significant (p-value ,0.05) difference in gender, age of children, postoperative heart rate, postoperative SPO2, and fentanyl consumption. The duration of surgery was significantly (p-value , 0.05) ...
https://apims.net/index.php/apims/article/view/420
Effects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. - Semantic ScholarEffects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. - Semantic Scholar
Semantic Scholar extracted view of [Effects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. by P Ben Driss et al.
https://www.semanticscholar.org/paper/Effects-of-bupivacaine-and-lidocaine-on-mitochond-Driss-Dubreuil/336d2158a05f66067d2814314bf031595a8db4ab
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical SiteBupivacaine vs Placebo for Unilateral Mastectomy Surgical Site
Breast Cancer clinical trial. Clinical trial for Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control.
http://inclinicaltrials.com/breast-cancer/NCT03351348/
Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks...
Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks-IJCA-Print ISSN No:-2394-4781 Online ISSN No:-2394-4994Article DOI No:-10.18231/2394-4994.2019.0025,Indian Journal of Clinical Anaesthesia-IP Innovative Publication Pvt Limited, Medical Journ
https://www.innovativepublication.com/journal-article-details/IJCA/article/8548/volume/236/issue/665
A physician-initiated study to investigate the safety and efficacy of bupivacaine (Exparel) in patients undergoing open ventral...A physician-initiated study to investigate the safety and efficacy of bupivacaine (Exparel) in patients undergoing open ventral...
This trial investigated the safety and efficacy of bupivacaine extended release (Exparel) in patients undergoing open ventral hernia repair or laparoscopic
http://adisinsight.springer.com/trials/700252815?error=cookies_not_supported&code=ee181627-38ad-48f1-ac94-106adc167725
Bupivacaine/hydromorphone Drug Interactions - Drugs.comBupivacaine/hydromorphone Drug Interactions - Drugs.com
825 medications are known to interact with bupivacaine/hydromorphone. Includes Advair Diskus (fluticasone/salmeterol), AndroGel (testosterone), Celebrex (celecoxib).
https://www.drugs.com/drug-interactions/bupivacaine-hydromorphone.html
The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery - ICH GCP - Clinical...The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery - ICH GCP - Clinical...
Sixty neonates and infants will be enrolled and randomised into two groups of n=30 each . For their surgical procedures, one group general (GA) anaesthesia the second group will receive a combined general and epidural anaesthesia (CGEA). Anaesthetic technique: Patients in the GA group will be induced with intravenous propofol (2-4 mg.kg-1) and fentanyl (2-4 µg.kg-1) and will receive rocuronium bromide (0.5 mg.kg-1) to facilitate endotracheal intubation. Anaesthesia will be maintained with sevoflurane (2-3%) in an air/oxygen mixture as well as intravenous fentanyl as required. In the (CGEA) 0.5 ml.kg-1 of 0.25% bupivacaine will be injected into the epidural catheter, followed by a continuous infusion of 0.1% bupivacaine at a rate of 0.2 mg.kg-1.hr-1 for up to 48 hours postoperatively. Assessment of anaesthetic efficacy will be measured Intraoperative care vital signs. And will continuously be monitored with a Datex AS/3
https://ichgcp.net/clinical-trials-registry/NCT03056261
Levobupivacaine Hydrochloride Local Anesthesia Drugs Levobupivacaine HCL 27262
Buy Levobupivacaine Hydrochloride Local Anesthesia Drugs Levobupivacaine HCL 27262 from Hongkong Pengfei Pharmaceutical Technology Co.,Ltd，Local Anesthesia Drugs Distributor online Service suppliers.
https://www.fatlosssteroids.com/local-46288-levobupivacaine-hydrochloride-local-anesthesia-drugs-levobupivacaine-hcl-27262.html
PWE-399 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer | GutPWE-399 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer | Gut
Results 70 patients (43% female; mean age 60 (±13) years) were included. The intervention and controls groups included 35 patients each. Diagnoses included diverticulitis (72%), colonic malignancy (14%), benign neoplasm (10%) and inflammatory bowel disease (4%). The median number of port sites was 4 (3-5), where 39% of patients had a midline extraction site vs. 61% with a Pfannenstiel. Total incision length was 9.5cm in 63% of patients. No difference in total opioid use was identified between groups (61mg vs. 70mg; p = 0.51) on univariate analysis. A sensitivity analysis was used to account for extremes in opioid use by removing the outermost 10thpercentiles of opioid use; no difference was confirmed (59mg vs. 60mg; p = 0.98). LOS was similar in both groups (median 5 days), with no difference in AEs. There was no significant difference in time to first flatus or bowel movement (p = 0.23 and p = 0.35, respectively). A multivariate logistic regression adjusting for ketorolac and acetaminophen use ...
http://gut.bmj.com/content/64/Suppl_1/A386.1
News Release - Investors - Pacira Pharmaceuticals, Inc.News Release - Investors - Pacira Pharmaceuticals, Inc.
EXPAREL and two other products have successfully utilized DepoFoam®, a unique and proprietary product delivery technology that encapsulates drugs without altering their molecular structure, and releases them over a desired period of time. Additional information about Pacira is available at www.pacira.com.. About EXPAREL®. EXPAREL (bupivacaine liposome injectable suspension) is currently indicated for single-dose infiltration into the surgical site to produce postsurgical analgesia. The product combines bupivacaine with DepoFoam®, a proven product delivery technology that delivers medication over a desired time period. EXPAREL represents the first and only multivesicular liposome local anesthetic that can be utilized in the peri- or postsurgical setting. By utilizing the DepoFoam platform, a single dose of EXPAREL delivers bupivacaine over time, providing significant reductions in cumulative pain score with a decrease in opioid consumption; the clinical benefit of the opioid reduction was not ...
http://investor.pacira.com/phoenix.zhtml?c=220759&p=irol-newsArticle_pf&ID=2127179
Anesthesia, Epidural | The Chopra LibraryAnesthesia, Epidural | The Chopra Library
Spinal and epidural anaesthesia were compared in 65 patients undergoing hip arthroplasty, with regard to the degree of sensory and motor blockade, cardiovascular effects, operating conditions, the dose of propofol required to produce satisfactory hypnosis, and complications. Epidural anaesthesia was successful in 30 patients using an initial dose of 15 ml of 0.5% bupivacaine, and spinal anaesthesia in 32 patients, using 4 ml 0.5% isobaric bupivacaine. The two techniques were similar with regard to the level of sensory blockade (T8), degree of hypotension and perioperative haemorrhage ...
http://isharonline.org/tags/anesthesia-epidural
Particulate Matter Triggers Hospira Recall of InjectionParticulate Matter Triggers Hospira Recall of Injection
Hospira, a Pfizer company, has issued a recall of one lot of 0.25% Bupivacaine Hydrochloride Injection at the hospital/retail level due to the presence of particulate matter within a single vial. If administered to a patient, it may result in swelling, irritation, or allergic response.
https://www.ncconsumer.org/news-articles/particulate-matter-triggers-hospira-recall-of-injection.html
Local Anesthetic Switching for Intrathecal Tachyphylaxis in... : Anesthesia & AnalgesiaLocal Anesthetic Switching for Intrathecal Tachyphylaxis in... : Anesthesia & Analgesia
A 47-yr-old woman with cervical cancer locally advanced and metastasized to the lung, mediastinum, and bones was admitted to the Pain Relief and Palliative Care Unit for severe lumbar and inguinal pain, which was aggravated by movement and caused by lumbar metastases. She had received different courses of chemotherapy and radiotherapy and was receiving a morphine slow-release preparation 180 mg daily, without reporting analgesic benefit. Opioid doses were increased up to 300 mg, but escalation was stopped because of the occurrence of drowsiness and vomiting. An intrathecal catheter was placed at the L3-4 level and was connected to a subcutaneous port and then to an external pump. A morphine/bupivacaine combination was given. The combination of the drugs was balanced to obtain the best analgesic effect with minimal neurological impairment in the lower limbs. The patient obtained adequate pain relief with doses of 8 mg of morphine and 40 mg of bupivacaine daily. Concentrations were adjusted to ...
https://journals.lww.com/anesthesia-analgesia/Fulltext/2003/07000/Local_Anesthetic_Switching_for_Intrathecal.33.aspx
ClinMed International LibraryClinMed International Library
Patients and Methods Following approval of the medical ethical committee of Ain Shams University, 40 patients ASA I-II physical status that were scheduled for elective urologic surgeries via abdominal wall incision under general anesthesia were included in this prospective study. All patients provided written informed consent. Patients with known allergy to any of the study medications, receiving medical therapies producing tolerance to opoids, with coagulapolly, and psychiatric problems were excluded. A preoperative evaluation was performed the day before surgery. Patients were divided into two groups: The TAP group (n=20) received TAP block with 0.25% bupivacaine (30mL) and infiltration group (n=20) the skin and subcutaneous tissues of the surgical incision and deep muscle layers were infiltrated with 0.25% bupivacaine (50ml), patients were monitored with electrocardiogram, invasive and non invasive arterial blood pressure, arterial oxygen saturation, end-tidal carbon dioxide monitoring. All ...
https://www.clinmedjournals.org/articles/ijaa/ijaa-1-006.php?jid=ijaa
Local Anesthetic Toxicity Differential DiagnosesLocal Anesthetic Toxicity Differential Diagnoses
While generally safe, local anesthetic agents can be toxic if administered inappropriately, and in some cases may cause unintended reactions even when properly administered. Adverse effects are usually caused by high plasma concentrations of the agent, which may result from one of the following: Inadvertent intravascular injection Excessive d...
https://emedicine.medscape.com/article/1844551-differential
Bupivacaine Liposome (Injection Route) Precautions - Mayo ClinicBupivacaine Liposome (Injection Route) Precautions - Mayo Clinic
Tell your doctor or nurse right away if you have the following symptoms with this medicine: anxiety; blurred vision; depression; drowsiness; lightheadedness; nausea or vomiting; numbness and tingling of the mouth or lips; restlessness; ringing in the ears; speech problems; or tremors. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; fever; increased sweating; lightheadedness or fainting; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat after receiving this medicine. ...
https://www.mayoclinic.org/drugs-supplements/bupivacaine-liposome-injection-route/precautions/drg-20075313
Papers with the keyword epiphisiodesis | Read by QxMDPapers with the keyword epiphisiodesis | Read by QxMD
Moya Moya is a rare disease of uncertain origin, characterised by stenosis of one or both of the internal carotid arteries and responsible of several neurological signs. We present the case of a boy with Moya Moya disease who was scheduled for an epiphisiodesis of the lateral malleola and had a spinal anaesthesia with hyperbaric bupivacaine 0.5% 10 mg without any perioperative complications. Any anaesthetic method could be used, provided special attention is given to avoid changes of capnea and blood pressure to preserve cerebral blood flow and palliate to cerebral flow steal ...
https://www.readbyqxmd.com/keyword/114508
Hospira, Inc. Articles, Photos, and Videos - CT NowHospira, Inc. Articles, Photos, and Videos - CT Now
Hospira Inc. announced June 17 it will initiate a voluntary nationwide recall to the user level for one lot of the anetsthetic 0.5% Marcaine¿ (Bupivacaine HCl Injection, USP), 30 mL, Single-dose Vial - Preservative Free (NDC 0409-1560-29), Lot 33-545-DD. The recall is due to a confirmed customer report of particulate embedded in the glass vial as well as visible particulate in the solution. To date, Hospira has not received reports of any adverse events associated with this issue for this lot. Hospira has attributed the embedded particulate to a suppliers glass defect. Hospira is working with its supplier on implementing corrective and preventive actions. Anyone with an existing... ...
http://www.ctnow.com/topic/business/chemical-industry/pharmaceutical-industry/hospira-inc.-ORCRP000017424-topic.html
BupivacaineBupivacaine
... is excreted in breast milk. Risks of stopping breast feeding versus stopping bupivacaine should be discussed with ... Bupivacaine was discovered in 1957. It is on the World Health Organization's List of Essential Medicines. Bupivacaine is ... Bupivacaine is available as a generic medication. Levobupivacaine is the (S)-(-)-enantiomer of bupivacaine, with a longer ... Ma TT, Wang YH, Jiang YF, Peng CB, Yan C, Liu ZG, Xu WX (June 2017). "Liposomal bupivacaine versus traditional bupivacaine for ...
https://en.wikipedia.org/wiki/Bupivacaine
Management of strabismusManagement of strabismus
... thereby providing about twice the alignment correction of bupivacaine alone. The effectiveness of a bupivacaine injection may ... After bupivacaine injection the muscle is inactivated by the drug's anesthetic effect for a day, and weakened by myofiber ... If bupivacaine injection is combined with a small dose of botulinum toxin in the antagonist muscle, eye deviation during ... Bupivacaine injection is not effective in paralyzed or atrophic muscles, or where there are restrictions to movement elsewhere ...
https://en.wikipedia.org/wiki/Management_of_strabismus
Ugi reactionUgi reaction
Examples include lidocaine and bupivacaine. Passerini reaction Ugi I, Meyr R, Fetzer U, Steinbrückner C (1959). "Versuche mit ...
https://en.wikipedia.org/wiki/Ugi_reaction
Pipecolic acidPipecolic acid
Bupivacaine Efrapeptin Gatto, Gregory J.; Boyne, Michael T.; Kelleher, Neil L.; Walsh, Christopher T. (2006). "Biosynthesis of ...
https://en.wikipedia.org/wiki/Pipecolic_acid
LevobupivacaineLevobupivacaine
Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is ... It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name ... ISBN 0-9757919-2-3 Gulec D, Karsli B, Ertugrul F, Bigat Z, Kayacan N (April 2014). "Intrathecal bupivacaine or levobupivacaine ... Systemic exposure to excessive quantities of bupivacaine mainly result in central nervous system (CNS) and cardiovascular ...
https://en.wikipedia.org/wiki/Levobupivacaine
CardiotoxicityCardiotoxicity
... or an incorrectly administered drug such as bupivacaine. One of the ways to detect cardiotoxicity at early stages when there is ...
https://en.wikipedia.org/wiki/Cardiotoxicity
LidocaineLidocaine
Bupivacaine is a safe alternative in this case. Impaired liver function - people with lowered hepatic function may have an ... Longer-acting substances such as bupivacaine are sometimes given preference for spinal and epidural anaesthesias; lidocaine, ... bupivacaine, ropivacaine, or levobupivacaine may decrease the risk of a person developing transient neurological symptoms. Low ...
https://en.wikipedia.org/wiki/Lidocaine
Potassium channel blockerPotassium channel blocker
Punke MA, Licher T, Pongs O, Friederich P (Jun 2003). "Inhibition of human TREK-1 channels by bupivacaine". Anesthesia and ... Bupivacaine Quinidine Fluoxetine Seproxetine (Norfluoxetine) 12-O-tetradecanoylphorbol-13-acetate (TPA) (phorbol 12-myristate ...
https://en.wikipedia.org/wiki/Potassium_channel_blocker
Botulinum toxin therapy of strabismusBotulinum toxin therapy of strabismus
In some interventions bupivacaine has been used alone. In others, a botulinum toxin injection into an extraocular muscle is ... The thickening of bupivacaine-injected extraocular muscle has been demonstrated by means of magnetic resonance imaging and by ... Bupivacaine is a local anaesthetic known to cause considerable myotoxicity and neurotoxicity. Its injection into muscle tissue ... Scott, AB; Miller, JM; Shieh, KR (April 2009). "Bupivacaine injection of the lateral rectus muscle to treat esotropia". J AAPOS ...
https://en.wikipedia.org/wiki/Botulinum_toxin_therapy_of_strabismus
Potassium channelPotassium channel
Punke MA, Licher T, Pongs O, Friederich P (June 2003). "Inhibition of human TREK-1 channels by bupivacaine". Anesthesia and ...
https://en.wikipedia.org/wiki/Potassium_channel
Alan B. ScottAlan B. Scott
Bupivacaine injection stresses a muscle and triggers a growth process, analogous to how load-bearing exercise builds skeletal ... Clinical studies over the past decade have demonstrated that bupivacaine injection in a weak muscle has a synergistic effect ... Miller, J. M.; Scott, A. B.; Danh, K. K.; Strasser, D.; Sane, M. (2013). "Bupivacaine injection remodels extraocular muscles ... Scott, Alan B.; Alexander, Danielle E.; Miller, Joel M. (February 6, 2007). "Bupivacaine injection of eye muscles to treat ...
https://en.wikipedia.org/wiki/Alan_B._Scott
NeosaxitoxinNeosaxitoxin
And last but not least, some degree of improving in therapeutic index of NSTX can be observed when is mixed with bupivacaine ... Padera R, Bellas E, Tse JY, Hao D, Kohane DS (May 2008). "Local Myotoxicity from Sustained Release of Bupivacaine from ... Beilin Y, Halpern S (August 2012). "Focused review: ropivacaine versus bupivacaine for epidural labor analgesia". Anesthesia & ... Additionally, two human reports demonstrated strong potentiation between NSTX anesthetic effect, bupivacaine and epinephrine. ...
https://en.wikipedia.org/wiki/Neosaxitoxin
Local anesthetic nerve blockLocal anesthetic nerve block
The amides include lidocaine, mepivacaine, prilocaine, bupivacaine, ropivacaine, and levobupivacaine. Chloroprocaine is a short ... bupivacaine, and mepivacaine. These drugs are often combined with adjuvants, drugs that boost the effect of each other, with ... drug (45-90 minutes), lidocaine and mepivacaine are intermediate duration (90-180 minutes), and bupivacaine, levobupivacaine, ...
https://en.wikipedia.org/wiki/Local_anesthetic_nerve_block
Local anestheticLocal anesthetic
It is reported that seizures are more likely to occur when bupivacaine is used, particularly in combination with chloroprocaine ... Lidocaine can be safely used but bupivacaine and mepivacaine should be avoided. Consultation with the obstetrician is vital ... Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... Although all local anesthetics potentially shorten the myocardial refractory period, bupivacaine blocks the cardiac sodium ...
https://en.wikipedia.org/wiki/Local_anesthetic
RopivacaineRopivacaine
As for bupivacaine, Celepid, a commonly available intravenous lipid emulsion, can be effective in treating severe ... Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... Ropivacaine was developed after bupivacaine was noted to be associated with cardiac arrest, particularly in pregnant women. ... Ropivacaine was found to have less cardiotoxicity than bupivacaine in animal models. Ropivacaine is contraindicated for ...
https://en.wikipedia.org/wiki/Ropivacaine
Lipid emulsionLipid emulsion
Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003). "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac ... "Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats". ... treating experimental models of severe cardiotoxicity from intravenous overdose of local anaesthetic drugs such as bupivacaine ...
https://en.wikipedia.org/wiki/Lipid_emulsion
MeloxicamMeloxicam
Bupivacaine/meloxicam Use During Pregnancy and Breastfeeding "Mobic- meloxicam tablet". DailyMed. Retrieved 15 May 2021. " ...
https://en.wikipedia.org/wiki/Meloxicam
Intravenous regional anesthesiaIntravenous regional anesthesia
Cardiotoxic local anesthetic agents like bupivacaine and etidocaine are strictly contraindicated. The safety and effectiveness ... However, cardiotoxic local anesthetic agents like bupivacaine and etidocaine are contraindicated. Shorter procedure times (for ...
https://en.wikipedia.org/wiki/Intravenous_regional_anesthesia
2,6-Xylidine2,6-Xylidine
Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine. 2,6-Xylidine is ...
https://en.wikipedia.org/wiki/2,6-Xylidine
DNA vaccineDNA vaccine
... by temporarily damaging muscle fibres with myotoxins such as bupivacaine; or 3) by using hypertonic solutions of saline or ...
https://en.wikipedia.org/wiki/DNA_vaccine
SameridineSameridine
"Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine". Anesthesia and ...
https://en.wikipedia.org/wiki/Sameridine
Combined spinal and epidural anaesthesiaCombined spinal and epidural anaesthesia
A small dose of local anaesthetic (e.g. bupivacaine) is then instilled. An opioid such as fentanyl may also be given if desired ... It further recommends the use of bupivacaine and fentanyl to establish the block. Combined spinal-epidural anaesthesia is a ...
https://en.wikipedia.org/wiki/Combined_spinal_and_epidural_anaesthesia
FentanylFentanyl
Spinal administration of hyperbaric bupivacaine with fentanyl may be the optimal combination. The almost immediate onset of ...
https://en.wikipedia.org/wiki/Fentanyl
Anesthesia for eye surgeryAnesthesia for eye surgery
Paracaine, tetracaine, bupivacaine, lidocaine etc. may also be used in place of xylocaine. Cataract surgery by ...
https://en.wikipedia.org/wiki/Anesthesia_for_eye_surgery
Ion trappingIon trapping
... like bupivacaine, pyrimethamine) are more charged inside the cell than outside. The cell membrane is permeable to non-ionized ( ...
https://en.wikipedia.org/wiki/Ion_trapping
Facet joint injectionFacet joint injection
A local anesthetic, like Bupivacaine, is injected into the area to numb the joint. The patient might feel a slight sting. ...
https://en.wikipedia.org/wiki/Facet_joint_injection
Bryan L. ReussBryan L. Reuss
"Efficacy of Continuous Subacromial Bupivacaine Infusion for Pain Control After Arthroscopic Rotator Cuff Repair". Journal of ... "Efficacy of continuous subacromial bupivacaine infusion for pain control after arthroscopic rotator cuff repair". J Shoulder ...
https://en.wikipedia.org/wiki/Bryan_L._Reuss
ChildbirthChildbirth
"Placental transfer and neonatal effects of epidural sufentanil and fentanyl administered with bupivacaine during labor". ...
https://en.wikipedia.org/wiki/Childbirth
NotexinNotexin
"Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine". Muscle & Nerve ...
https://en.wikipedia.org/wiki/Notexin
Veterinary surgeryVeterinary surgery
Lidocaine, mepivacaine, and bupivacaine are the most commonly used local anesthetics used in veterinary medicine. Sedation ...
https://en.wikipedia.org/wiki/Veterinary_surgery
Bupivacaine/meloxicam Side Effects: Common, Severe, Long Term - Drugs.comBupivacaine/meloxicam Side Effects: Common, Severe, Long Term - Drugs.com
Learn about the potential side effects of bupivacaine/meloxicam. Includes common and rare side effects information for ... Applies to bupivacaine / meloxicam: injection solution extended release.. Warning. Injection route (Solution, Extended Release) ... Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine / meloxicam:. ... Applies to bupivacaine / meloxicam: injectable solution extended release.. General. The most common adverse reactions were ...
https://www.drugs.com/sfx/bupivacaine-meloxicam-side-effects.html
MedlinePlus - Search Results for: BUPIVACAINE OR IODINE OR LIDOCAINE
Information , Dietary Supplement Fact Sheets , Iodine , Iodine - Consumer Iodine Fact Sheet for Consumers Have a question? Ask ... health professional fact sheet on Iodine . What is iodine and what does it do? Iodine is a ...
https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=BUPIVACAINE+OR+IODINE+OR+LIDOCAINE
Prospective evaluation of combined local bupivacaine and steroid injections for the management of chronic vaginal and perineal...Prospective evaluation of combined local bupivacaine and steroid injections for the management of chronic vaginal and perineal...
Prospective evaluation of combined local bupivacaine and steroid injections for the management of chronic vaginal and perineal ... Patients underwent local injections with a combination of 0.5% bupivacaine (10 ml), hydrocortisone (100 mg) and hyaluronidase ( ...
https://pubmed.ncbi.nlm.nih.gov/21079978/
DailyMed - SENSORCAINE- bupivacaine hydrochloride injection, solution SENSORCAINE MPF- bupivacaine hydrochloride and...DailyMed - SENSORCAINE- bupivacaine hydrochloride injection, solution SENSORCAINE MPF- bupivacaine hydrochloride and...
BUPIVACAINE HYDROCHLORIDE (UNII: 7TQO7W3VT8) (BUPIVACAINE - UNII:Y8335394RO) BUPIVACAINE HYDROCHLORIDE ANHYDROUS. 2.5 mg in 1 ... BUPIVACAINE HYDROCHLORIDE (UNII: 7TQO7W3VT8) (BUPIVACAINE - UNII:Y8335394RO) BUPIVACAINE HYDROCHLORIDE ANHYDROUS. 5 mg in 1 mL ... BUPIVACAINE HYDROCHLORIDE (UNII: 7TQO7W3VT8) (BUPIVACAINE - UNII:Y8335394RO) BUPIVACAINE HYDROCHLORIDE ANHYDROUS. 7.5 mg in 1 ... BUPIVACAINE HYDROCHLORIDE (UNII: 7TQO7W3VT8) (BUPIVACAINE - UNII:Y8335394RO) BUPIVACAINE HYDROCHLORIDE ANHYDROUS. 2.5 mg in 1 ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eb6d8fee-def4-4c96-9972-695e8cea8ea8
LOINC LG44411-3 - Bupivacaine|Pt|Ser/PlasLOINC LG44411-3 - Bupivacaine|Pt|Ser/Plas
LG44411-3Bupivacaine,. Pt,. Ser/PlasActive. Basic Attributes. Version First Released. Pending promotion to Production status. ... Bupivacaine [Mass/volume] in Serum or Plasma. LOINC Copyright. Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved ... Bupivacaine [Moles/volume] in Serum or Plasma. 3412-4. ... LOINC Code LG44411-3 Bupivacaine,Pt,Ser/Plas ...
https://loinc.org/LG44411-3/
Effect of Peritumoral Bupivacaine on Primary and Distal Hyperalgesia in Cancer-Induced Bone Pain - Amrita Vishwa VidyapeethamEffect of Peritumoral Bupivacaine on Primary and Distal Hyperalgesia in Cancer-Induced Bone Pain - Amrita Vishwa Vidyapeetham
Effect of Peritumoral Bupivacaine on Primary and Distal Hyperalgesia in Cancer-Induced Bone Pain. Publication Type : Journal ... Peritumoral administration of bupivacaine in 7-day post-tumor-induced (PTI) rats resulted in a reversal of both primary and ... However, bupivacaine failed to reverse distal hyperalgesia in 14 day-PTI rats. ATF3 and GFAP expression were much enhanced in ... Bupivacaine was injected peritumorally at day 7 or day 14 post-tumor induction, and withdrawal thresholds in response to ...
https://www.amrita.edu/publication/effect-of-peritumoral-bupivacaine-on-primary-and-distal-hyperalgesia-in-cancer-induced-bone-pain/
EPINEPHRINE INCREASES BUPIVACAINE TOXICITY IN RATS | Anesthesiology | American Society of AnesthesiologistsEPINEPHRINE INCREASES BUPIVACAINE TOXICITY IN RATS | Anesthesiology | American Society of Anesthesiologists
EPINEPHRINE INCREASES BUPIVACAINE TOXICITY IN RATS W W Kinney, MD; W W Kinney, MD ... W W Kinney, S A Hyraan, J L Horn; EPINEPHRINE INCREASES BUPIVACAINE TOXICITY IN RATS. Anesthesiology 1991; 75:A681 doi: https ... Resuscitation with Lipid versus Epinephrine in a Rat Model of Bupivacaine Overdose Anesthesiology (May 2008) ... Epinephrine Impairs Lipid Resuscitation from Bupivacaine Overdose: A Threshold Effect Anesthesiology (September 2009) ...
https://pubs.asahq.org/anesthesiology/article/75/3/A681/50726/EPINEPHRINE-INCREASES-BUPIVACAINE-TOXICITY-IN-RATS
Specified Sedative Completed Phase 4 Trials for Bupivacaine (DB00297) | DrugBank OnlineSpecified Sedative Completed Phase 4 Trials for Bupivacaine (DB00297) | DrugBank Online
Specified Sedative Completed Phase 4 Trials for Bupivacaine (DB00297). Back to Specified Sedative ...
https://go.drugbank.com/indications/DBCOND0077361/clinical_trials/DB00297?phase=4&status=completed
Generic BUPIVACAINE HYDROCHLORIDE INN equivalents, pharmaceutical patent and freedom to operateGeneric BUPIVACAINE HYDROCHLORIDE INN equivalents, pharmaceutical patent and freedom to operate
BUPIVACAINE HYDROCHLORIDE INN patent status, expiry and generic drug launch ... BUPIVACAINE HYDROCHLORIDE. bupivacaine hydrochloride. INJECTABLE;INJECTION. 070585-001. Mar 3, 1987. AP. RX. No. No. See Plans ... What are the generic sources for bupivacaine hydrochloride and what is the scope of patent protection?. Bupivacaine ... What excipients (inactive ingredients) are in bupivacaine hydrochloride?. bupivacaine hydrochloride excipients list. ...
https://www.drugpatentwatch.com/p/generic-api/bupivacaine+hydrochloride
Allergy Bupivacaine Fluorescence Assay Skin - Preparation, Procedure, Cost, Normal Range | PractoAllergy Bupivacaine Fluorescence Assay Skin - Preparation, Procedure, Cost, Normal Range | Practo
Book Allergy Bupivacaine Fluorescence Assay Skin @Home at Best Prices at the slot of your choice. View details of test: When to ... Bupivacaine is a local anaesthetic drug belonging to the amino amide group. It is commonly marketed under various trade names, ... No special preparation is needed for Allergy Bupivacaine Fluorescence Assay Skin. Inform your doctor if you are on any ... Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. However, adverse drug reactions (ADRs) are rare when ...
https://www.practo.com/tests/allergy-bupivacaine-fluorescence-assay-skin/p
Bupivacaine 2.5 mg/ml Solution for Injection | License Info | Baxter Holding B.V. | Medicines.ieBupivacaine 2.5 mg/ml Solution for Injection | License Info | Baxter Holding B.V. | Medicines.ie
The Summary of Product Characteristics (SPC) is a specific document, the wording of which has been agreed with the regulatory authority as part of the medicine approval process. It is required before any medicine is allowed on the market in Europe. It is designed to assist doctors and pharmacists in prescribing and supplying the product ...
https://www.medicines.ie/medicines/bupivacaine-2-5-mg-ml-solution-for-injection-34967/license-info
Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison...Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison...
... bupivacaine hydrochloride, diclofenac sodium, gabapentin, orphenadrine citrate, pentoxifylline) from two popular formulations ... Related Keywords: Xuexuan Wang, PhD, Laura Black, BSc, ketamine, bupivacaine, diclofenac, gabapentin, orphenadrine, ... Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison ... Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison ...
https://ijpc.com/Abstracts/Abstract.cfm?ABS=3751
Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in labor. | Scholars...Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in labor. | Scholars...
Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in labor. ... Each patient received a 20 mL epidural bolus of bupivacaine, levobupivacaine, or ropivacaine determined by the MMLAC model. ... The estimated MMLAC with the 95% confidence intervals (CI) were: Bupivacaine: 0.26% wt/vol (0.22-0.30); Levobupivacaine: 0.30% ... Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in labor. Journal ...
https://scholars.duke.edu/display/pub696186
The effect of wound irrigation with bupivacaine on postoperative analgesia of the feline onychectomy patient | Citedby Results ...The effect of wound irrigation with bupivacaine on postoperative analgesia of the feline onychectomy patient | Citedby Results ...
... an elective onychectomy were evaluated using a double-blind study design to determine if wound irrigation with bupivacaine pri ... The effect of wound irrigation with bupivacaine on postoperative analgesia of the feline onychectomy patient. J Am Anim Hosp ...
https://meridian.allenpress.com/jaaha/crossref-citedby/175228
Bupivacaine in the product Tri-solfen Topical Anaesthetic and Antiseptic Solution for Pain Relief in Lambs | Australian...Bupivacaine in the product Tri-solfen Topical Anaesthetic and Antiseptic Solution for Pain Relief in Lambs | Australian...
... which includes an application for approval of the new active constituent bupivacaine, for use in lambs called TRISOLFEN Topical ... Bupivacaine in the product Tri-solfen Topical Anaesthetic and Antiseptic Solution for Pain Relief in Lambs PDF ... Bupivacaine in the product Tri-solfen Topical Anaesthetic and Antiseptic Solution for Pain Relief in Lambs ... which includes an application for approval of the new active constituent bupivacaine, for use in lambs called TRISOLFEN Topical ...
https://apvma.gov.au/node/14121
The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...
The purpose of this study was to compare the effectiveness of liposomal bupivacaine with bupivacaine following total hip ... Liposomal bupivacaine is a formulation of local anesthetic which has the potential to provide anesthesia for up to 72  ... Liposomal bupivacaine administration during total hip arthroplasty appears to decrease the need for opioid use post operatively ... The results of this study justify the need for a well-designed randomized controlled trial utilizing liposomal bupivacaine as ...
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-15-310
A prospective, comparative, randomised, double blind study on the efficacy of addition of clonidine to 0.25% bupivacaine in...A prospective, comparative, randomised, double blind study on the efficacy of addition of clonidine to 0.25% bupivacaine in...
Brachial Plexus Block with Bupivacaine or Bupivacaine Plus Fentanyl: A Comparative Study | Regional Anesthesia & Pain MedicineBrachial Plexus Block with Bupivacaine or Bupivacaine Plus Fentanyl: A Comparative Study | Regional Anesthesia & Pain Medicine
Brachial Plexus Block with Bupivacaine or Bupivacaine Plus Fentanyl: A Comparative Study ... Brachial Plexus Block with Bupivacaine or Bupivacaine Plus Fentanyl: A Comparative Study ... Brachial Plexus Block with Bupivacaine or Bupivacaine Plus Fentanyl: A Comparative Study ...
https://rapm.bmj.com/content/18/Suppl_1/5.citation-tools
Zynrelef (bupivacaine and meloxicam) extended-release solution | CenterWatchZynrelef (bupivacaine and meloxicam) extended-release solution | CenterWatch
Zynrelef is a fixed-dose combination of bupivacaine and meloxicam.. Bupivacaine: Local anesthetics block the generation and the ... Bupivacaine HCl and saline placebo were administered by injection and instillation, respectively. Pain intensity was rated by ... Bupivacaine HCl and saline placebo were administered by injection and instillation, respectively. Pain intensity was rated by ... Zynrelef contains bupivacaine, an amide local anesthetic, and meloxicam, a nonsteroidal anti-inflammatory drug (NSAID). ...
https://cms.centerwatch.com/directories/1067-fda-approved-drugs/listing/4703-zynrelef-bupivacaine-and-meloxicam-extended-release-solution
Bupivacaine | Colorado PROFILES
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Liposomal bupivacaineFixed-dose combination of bupiva0.25AnalgesiaRopivacaineHyperbaricLIDOCAINESensorcaineExtended-release bupivacaineLevobupivacaineFentanylAnalgesicEpinephrineContains bupivacaineIntrathecal bupivacaineInfiltrationTotal hip arthroplMeloxicamBlockadeInjectionsSingle doseOpioidBetamethasoneMeSHPediatricBlockNerveLocal anesthetics
Liposomal bupivacaine19
  • Liposomal bupivacaine is a formulation of local anesthetic which has the potential to provide anesthesia for up to 72 hours following administration. (biomedcentral.com)
  • The purpose of this study was to compare the effectiveness of liposomal bupivacaine with bupivacaine following total hip arthroplasty. (biomedcentral.com)
  • A retrospective chart review was performed on 28 patients undergoing total hip arthroplasty or hip resurfacing who received intraoperative administration of liposomal bupivacaine. (biomedcentral.com)
  • Liposomal bupivacaine administration during total hip arthroplasty appears to decrease the need for opioid use post operatively and decrease length of stay. (biomedcentral.com)
  • The results of this study justify the need for a well-designed randomized controlled trial utilizing liposomal bupivacaine as part of multimodal analgesia during THA. (biomedcentral.com)
  • Liposomal bupivacaine is a formulation of local anesthetic approved by the FDA in October 2011 for single-dose infiltration in the surgical site for postsurgical analgesia. (biomedcentral.com)
  • Evaluation of Diaphragmatic Function after Interscalene Block with Liposomal Bupivacaine: A Randomized Controlled Trial. (ucdenver.edu)
  • Comparing liposomal bupivacaine plus bupivacaine to bupivacaine alone in interscalene blocks for rotator cuff repair surgery: a randomized clinical trial. (ucdenver.edu)
  • Earlier liposomal bupivacaine blocks improve analgesia and decrease opioid requirements for bariatric surgery patients. (ucdenver.edu)
  • A randomized clinical trial of single dose liposomal bupivacaine versus indwelling analgesic catheter in patients undergoing surgical stabilization of rib fractures. (ucdenver.edu)
  • Single-Shot Liposomal Bupivacaine Reduces Postoperative Narcotic Use Following Outpatient Rotator Cuff Repair: A Prospective, Double-Blinded, Randomized Controlled Trial. (ucdenver.edu)
  • Peripheral Nerve Blockade with Combined Standard and Liposomal Bupivacaine in Major Lower-Extremity Amputation. (ucdenver.edu)
  • A descriptive of the existing literature on the utility of liposomal bupivacaine in total hip arthroplasty. (openmedicalpublishing.org)
  • Liposomal bupivacaine has been integrated into clinical practice within many surgical disciplines to reduce post-operative pain and opioid consumption. (openmedicalpublishing.org)
  • The purpose of the present investigation is to summarize the current use of liposomal bupivacaine after total hip arthroplasty and to shed light on the prospect of liposomal bupivacaine to reduce opioid use after total hip arthroplasty. (openmedicalpublishing.org)
  • A total of 9 articles were included regarding the use of liposomal bupivacaine in total hip arthroplasty. (openmedicalpublishing.org)
  • Liposomal bupivacaine reduces postoperative opioid use, patient-reported outcomes, length of stay, and time to ambulation, yet is more expensive than traditional bupivacaine. (openmedicalpublishing.org)
  • Liposomal bupivacaine represents a useful adjunct for multimodal pain strategies in total hip arthroplasty with sufficient evidence to suggest that it may be useful in decreasing postoperative opioid use. (openmedicalpublishing.org)
  • A randomized-controlled trial comparing liposomal bupivacaine, plain bupivacaine, and the mixture of liposomal bupivacaine and plain bupivacaine in transversus abdominus plane block for postoperative analgesia for open abdominal hysterectomies. (amedeo.com)
Fixed-dose combination of bupiva1
  • Zynrelef is a fixed-dose combination of bupivacaine and meloxicam. (centerwatch.com)
0.253
  • A prospective, comparative, randomised, double blind study on the efficacy of addition of clonidine to 0.25% bupivacaine in scalp block for supratentorial craniotomies. (snacc.org)
  • Patients were randomized to receive a total of 150 mg (0.25% 60 mL) bupivacaine via periportal (20 mL) and intraperitoneal (40 mL with 1:200,000 epinephrine) administration of each. (elsevier.com)
  • Bupivacaine 0.25% may be used in combination with lidocaine plus epinephrine (50:50 mixture). (medscape.com)
Analgesia2
  • The purpose of this study was to evaluate the effect of Dexamethasone as adjuvant to intrathecal Bupivacaine, on onset time and duration of spinal analgesia. (who.int)
  • CUPERTINO, Calif., Feb. 2, 2021 /PRNewswire/ -- DURECT Corporation (Nasdaq: DRRX) today announced that the U.S. Food and Drug Administration (FDA) has approved Posimir (bupivacaine solution) for infiltration use in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression. (cliniexpert.com)
Ropivacaine7
  • Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in labor. (duke.edu)
  • The objective of this clinical trial was to simultaneously determine the motor blocking minimum local anesthetic concentrations (MMLAC) and the relative potency ratios for racemic bupivacaine, levobupivacaine, and ropivacaine during labor. (duke.edu)
  • Each patient received a 20 mL epidural bolus of bupivacaine, levobupivacaine, or ropivacaine determined by the MMLAC model. (duke.edu)
  • ANOVA of MMLAC estimates was significant (F = 3.32, P = .046), and when ranked by analgesic potencies, a significant linear trend (P = .014) to increasing motor blocking potencies from ropivacaine to levobupivacaine to bupivacaine was also found. (duke.edu)
  • We aimed to investigate the efficacy of either plain or hyperbaric solutions of intrathecal bupivacaine and ropivacaine on maternal block characteristics, complications, side effects and neonatal parameters to find out which is superior in a single study. (gazi.edu.tr)
  • 0.75% ropivacaine is a better anesthetic when compared to bupivacaine and lignocaine for pain control during third molar extractions. (ejmcm.com)
  • 2022). 'Assessment Of Efficacy Of Lignocaine, Ropivacaine, And Bupivacaine In Control Of Pain During Extraction Of Mandibular Posterior Teeth', European Journal of Molecular & Clinical Medicine , 9(7), pp. 1775-1779. (ejmcm.com)
Hyperbaric6
  • Study group received intrathecal 15 mg (3 ml) of 0.5% hyperbaric Bupivacaine heavy and 8 mg (2.0ml) of preservative free Dexamethasone(Total 5.0 ml solution) and control group received intrathecal 15 mg (3 ml) of 0.5% hyperbaric Bupivacaine heavy with 2.0 ml normal saline (Total 5.0 ml solution). (who.int)
  • Comparison of the efficacy of 0.5% isobaric bupivacaine, 0.5% levobupivacaine, and 0.5% hyperbaric bupivacaine for spinal anesthesia in lower limb surgeries. (bvsalud.org)
  • Various advantages of isobaric bupivacaine , levobupivacaine , and hyperbaric bupivacaine are described. (bvsalud.org)
  • The purpose of the study was to compare the efficacy of spinal anesthesia (SA) performed with 0.5% isobaric bupivacaine , 0.5% levobupivacaine , and 0.5% hyperbaric bupivacaine . (bvsalud.org)
  • in group 2 (2L)-3 ml of 0.5% levobupivacaine (n = 37), in group 3 (3H)-3 ml of 0.5% hyperbaric bupivacaine (n = 37). (bvsalud.org)
  • Comparative Study of Efficacay of Intrathecal Fentanyl and Intrathecal Tramadol Added as Adjuvant to 0.5% Hyperbaric Bupivacaine in Patients Undergoing Surgeries Under Spinal Anaesthesia. (aimdrjournal.com)
LIDOCAINE5
  • The pK a of bupivacaine (8.1) is similar to that of lidocaine (7.86). (nih.gov)
  • However, bupivacaine possesses a greater degree of lipid solubility and is protein bound to a greater extent than lidocaine. (nih.gov)
  • In this multicenter, double-blind, parallel-group, active- and placebo-controlled clinical trial, 412 patients undergoing unilateral simple bunionectomy with a lidocaine Mayo block were randomized to 1 of the following 3 treatment groups in a 3:3:2 ratio (respectively): Zynrelef 60 mg/1.8 mg, bupivacaine HCl 50 mg, or saline placebo. (centerwatch.com)
  • Lidocaine is an amide local anesthetic used in a 0.5-1% concentration in combination with bupivacaine (50:50 mixture). (medscape.com)
  • Bupivacaine and lidocaine compared for postoperative pain control. (bvsalud.org)
Sensorcaine1
  • Sensorcaine ® (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. (nih.gov)
Extended-release bupivacaine1
  • A new extended-release bupivacaine suspension bupivacaine (ERSB) delivers 3 days of local anesthetic and has been shown to reduce pain and narcotic usage in some patient groups but this issue is largely unstudied in urologic surgery. (turkishjournalofurology.com)
Levobupivacaine1
  • A randomized-controlled, double-blind comparison of the postoperative analgesic efficacy of caudal bupivacaine and levobupivacaine in minor pediatric surgery. (ktu.edu.tr)
Fentanyl1
  • 1998. Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. . (cornell.edu)
Analgesic2
  • Regarding the controversy in the role of injection of local analgesic drugs in tonsillectomy and the high prevalence of this procedure, the present study was performed to evaluate the effect of local bupivacaine infiltration, as an analgesic drug on pain after tonsillectomy in patients older than 9 years of ages. (tanaffosjournal.ir)
  • Posimir (bupivacaine solution) for infiltration use is a novel and proprietary product that combines the strength of 660 mg of bupivacaine base with the innovative SABER® platform technology, enabling continuous sustained delivery of a non-opioid local analgesic over 3 days in adults. (cliniexpert.com)
Epinephrine6
  • Solutions of bupivacaine HCl may be autoclaved if they do not contain epinephrine. (nih.gov)
  • Each mL contains bupivacaine hydrochloride and 0.005 mg epinephrine, with 0.5 mg sodium metabisulfite as an antioxidant and 0.2 mg citric acid (anhydrous) as stabilizer. (nih.gov)
  • Objective: After knee surgeries, the intra-articular administration of a solution mixing bupivacaine and epinephrine is a common regimen. (scitechnol.com)
  • After closure of arthrotomy, a solution containing a 40 ml vial of 0.5% bupivacaine with epinephrine 1: 200000 was given prior to the deflation of tourniquet, and two groups were simply divided according to the intra-articular injection or not. (scitechnol.com)
  • 9 ], who observed no significant different postoperative blood loss after the intra-articular bupivacaine and epinephrine lavage. (scitechnol.com)
  • Therefore, the aim of this study was to determine whether local bupivacaine and epinephrine can reduce postoperative blood loss in our primary TKAs without drains. (scitechnol.com)
Contains bupivacaine1
  • Zynrelef contains bupivacaine, an amide local anesthetic, and meloxicam, a nonsteroidal anti-inflammatory drug (NSAID). (centerwatch.com)
Intrathecal bupivacaine1
  • 5.Wahi A, Singh AK, Syal K, Sood A, Pathania J. Comparative efficacy of intrathecal bupivacaine alone and combination of bupivacaine with clonidine in spinal anaesthesia. (bvsalud.org)
Infiltration2
  • Bupivacaine is indicated for local anesthesia including infiltration, nerve block, epidural, and intrathecal anesthesia. (practo.com)
  • Effect of Local Bupivacaine Infiltration on Post-Tonsillectomy Pain', TANAFFOS (Respiration) , 5(1(winter)), pp. 45-49. (tanaffosjournal.ir)
Total hip arthropl1
  • A control group of 30 patients who had previously undergone total hip arthroplasty or hip resurfacing and had received intraoperative administration of bupivacaine also underwent a chart review. (biomedcentral.com)
Meloxicam5
  • Bupivacaine / meloxicam is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.Gastrointestinal Bleeding, Ulceration, and PerforationNSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. (drugs.com)
  • Along with its needed effects, bupivacaine / meloxicam may cause some unwanted effects. (drugs.com)
  • Some side effects of bupivacaine / meloxicam may occur that usually do not need medical attention . (drugs.com)
  • The combination of bupivacaine and meloxicam was approved by the FDA in May 2021. (medscape.com)
  • Among 418 patients undergoing unilateral open inguinal herniorrhaphy, bupivacaine/meloxicam demonstrated superior, sustained pain reduction through 72 hours, significantly reduced opioid consumption, and resulted in significantly more opioid-free subjects compared with saline placebo and bupivacaine. (medscape.com)
Blockade1
  • Epidural blockade with bupivacaine and morphine was also performed. (bvsalud.org)
Injections1
  • Patients underwent local injections with a combination of 0.5% bupivacaine (10 ml), hydrocortisone (100 mg) and hyaluronidase (1,500 IU). (nih.gov)
Single dose1
  • Posimir contains more bupivacaine than any other approved single-dose sustained-release bupivacaine product. (cliniexpert.com)
Opioid1
  • Continuous local bupivacaine wound infusion reduces oral opioid use for acute postoperative pain control following myelomeningocele repair. (ucdenver.edu)
Betamethasone1
  • They injected betamethasone and bupivacaine in equal parts (1-2 mL/injection) into an EDS patient and reported 50% relief of pain with one injection. (medscape.com)
MeSH1
  • Bupivacaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Pediatric1
  • Appropriate studies have not been performed on the relationship of age to the effects of bupivacaine injection in the pediatric population. (purecaremeds.com)
Block5
  • In this study, we aim to understand how tumor-induced primary and distal pain sensitivities are affected by bupivacaine-induced block of bone nerve endings in a rat model of CIBP. (amrita.edu)
  • Bupivacaine: Local anesthetics block the generation and the conduction of nerve impulses presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. (centerwatch.com)
  • Here, we present a case of severe chronic PHI successfully treated with supraorbital nerve block using a high concentration of tetracaine dissolved in bupivacaine. (springeropen.com)
  • After these conventional treatments, left supraorbital nerve block using 4% tetracaine dissolved with 0.5% bupivacaine was conducted. (springeropen.com)
  • Peripheral nerve block using 4% tetracaine dissolved with 0.5% bupivacaine was beneficial in relieving PHI in the ophthalmic division of the trigeminal nerve. (springeropen.com)
Nerve1
  • Bupivacaine injection ( ketamine hcl ) causes a loss of feeling and prevents pain by blocking signals at the nerve endings. (purecaremeds.com)
Local anesthetics1
  • Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. (nih.gov)
Raynaud Phenomenon Medication: Calcium channel blockers, Prostaglandins, Nitrates, Angina, Phosphodiesterase-5 Enzyme...
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Nerve Entrapment Syndromes of the Lower Extremity Medication: Local Anesthetics, Anticonvulsants, Other, Antidepressants, TCAs,...
Nerve Entrapment Syndromes of the Lower Extremity Medication: Local Anesthetics, Anticonvulsants, Other, Antidepressants, TCAs,... (medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
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Infraclavicular Nerve Block Medication: Local Anesthetics
Infraclavicular Nerve Block Medication: Local Anesthetics (emedicine.medscape.com)
(emedicine.medscape.com)
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination
Acute Intermittent Porphyria Clinical Presentation: History, Physical Examination (medscape.com)
Open Inguinal Hernia Repair Periprocedural Care: Preprocedural Planning, Equipment, Patient Preparation
Open Inguinal Hernia Repair Periprocedural Care: Preprocedural Planning, Equipment, Patient Preparation (medscape.com)
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Complex Regional Pain Syndromes Treatment & Management: Medical Care, Surgical Care, Consultations
Complex Regional Pain Syndromes Treatment & Management: Medical Care, Surgical Care, Consultations (medscape.com)
Infraorbital Nerve Block: Overview, Indications, Contraindications
Infraorbital Nerve Block: Overview, Indications, Contraindications (medscape.com)
Therapeutic Injections for Pain Management: Types of Therapeutic Injections, Guidelines for Therapeutic Application, Technical...
Therapeutic Injections for Pain Management: Types of Therapeutic Injections, Guidelines for Therapeutic Application, Technical... (medscape.com)
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Bupropion (Oral Route) Before Using - Mayo Clinic (mayoclinic.org)
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Cauda Equina and Conus Medullaris Syndromes: Background, Anatomy, Pathophysiology (medscape.com)
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Cauda Equina and Conus Medullaris Syndromes Treatment & Management: Approach Considerations, Emergency Department Care,... (medscape.com)
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Bicipital Tendonitis Medication: Nonsteroidal anti-inflammatory drugs (NSAIDs), Local anesthetics, Glucocorticoids (medscape.com)
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