Bupivacaine: A widely used local anesthetic agent.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Anesthesia, Spinal: Procedure in which an anesthetic is injected directly into the spinal cord.Analgesia, Epidural: The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Analgesia, Obstetrical: The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.Anesthesia, Epidural: Procedure in which an anesthetic is injected into the epidural space.Anesthesia, Obstetrical: A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Pain, Postoperative: Pain during the period after surgery.Anesthesia, Caudal: Epidural anesthesia administered via the sacral canal.Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Sufentanil: An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)Anesthetics, Combined: The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Adjuvants, Anesthesia: Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)Injections, Spinal: Introduction of therapeutic agents into the spinal region using a needle and syringe.Cesarean Section: Extraction of the FETUS by means of abdominal HYSTEROTOMY.Carticaine: A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Analgesia: Methods of PAIN relief that may be used with or in place of ANALGESICS.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.Subarachnoid Space: The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.Analgesia, Patient-Controlled: Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.Brachial Plexus: The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.Labor, Obstetric: The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).Injections, Epidural: The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.Ambulatory Surgical Procedures: Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Specific Gravity: The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Thoracotomy: Surgical incision into the chest wall.Hernia, Inguinal: An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.Hydrocodone: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Oxymorphone: An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Speech Disorders: Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.Postural Orthostatic Tachycardia Syndrome: A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Nanospheres: Spherical particles of nanometer dimensions.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers. (1/1144)
BACKGROUND: Intrathecal adjuncts often are used to enhance small-dose spinal bupivacaine for ambulatory anesthesia. Neostigmine is a novel spinal analgesic that could be a useful adjunct, but no data exist to assess the effects of neostigmine on small-dose bupivacaine spinal anesthesia. METHODS: Eighteen volunteers received two bupivacaine spinal anesthetics (7.5 mg) in a randomized, double-blinded, crossover design. Dextrose, 5% (1 ml), was added to one spinal infusion and 6.25, 12.5, or 50 microg neostigmine in dextrose, 5%, was added to the other spinal. Sensory block was assessed with pinprick; by the duration of tolerance to electric stimulation equivalent to surgical incision at the pubis, knee, and ankle; and by the duration of tolerance to thigh tourniquet. Motor block at the quadriceps was assessed with surface electromyography. Side effects (nausea, vomiting, pruritus, and sedation) were noted. Hemodynamic and respiratory parameters were recorded every 5 min. Dose-response relations were assessed with analysis of variance, paired t tests, or Spearman rank correlation. RESULTS: The addition of 50 microg neostigmine significantly increased the duration of sensory and motor block and the time until discharge criteria were achieved. The addition of neostigmine produced dose-dependent nausea (33-67%) and vomiting (17-50%). Neostigmine at these doses had no effect on hemodynamic or respiratory parameters. CONCLUSIONS: The addition of 50 microg neostigmine prolonged the duration of sensory and motor block. However, high incidences of side effects and delayed recovery from anesthesia with the addition of 6.25 to 50 microg neostigmine may limit the clinical use of these doses for outpatient spinal anesthesia. (+info)A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. (2/1144)
BACKGROUND: This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. METHODS: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 ml bupivacaine, 0.125%, plus 7.5 microg sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 microg sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. RESULTS: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/-15 min and lasted +/-90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P<0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. CONCLUSIONS: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade. (+info)Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles. (3/1144)
BACKGROUND: Although various local anesthetics can cause histologic damage to skeletal muscle when injected intramuscularly, bupivacaine appears to have an exceptionally high rate of myotoxicity. Research has suggested that an effect of bupivacaine on sarcoplasmic reticulum Ca2+ release is involved in its myotoxicity, but direct evidence is lacking. Furthermore, it is not known whether the toxicity depends on the unique chemical characteristics of bupivacaine and whether the toxicity is found only in skeletal muscle. METHODS: The authors studied the effects of bupivacaine and the similarly lipid-soluble local anesthetic, tetracaine, on the Ca2+ release channel-ryanodine receptor of sarcoplasmic reticulum in swine skeletal and cardiac muscle. [3H]Ryanodine binding was used to measure the activity of the Ca2+ release channel-ryanodine receptors in microsomes of both muscles. RESULTS: Bupivacaine enhanced (by two times at 5 mM) and inhibited (66% inhibition at 10 mM) [3H]ryanodine binding to skeletal muscle microsomes. In contrast, only inhibitory effects were observed with cardiac microsomes (about 3 mM for half-maximal inhibition). Tetracaine, which inhibits [3H]ryanodine binding to skeletal muscle microsomes, also inhibited [3H]ryanodine binding to cardiac muscle microsomes (half-maximal inhibition at 99 microM). CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic. Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics. The specific action of tetracaine to inhibit Ca2+ release channel-ryanodine receptor activity may in part counterbalance the nonspecific action, resulting in moderate myotoxicity. (+info)Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery. (4/1144)
We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or placebo. During the first 24 h after surgery, all patients received 4 ml h-1 of epidural bupivacaine 2.5 mg ml-1. From 24 to 48 h after operation, patients received epidural morphine 0.2 mg h-1 preceded by a bolus dose of 2 mg. In addition, patient-controlled analgesia (PCA) with i.v. morphine (2.5 mg, lockout time 15 min) was offered from 0 to 48 h after operation. Patients who received ketamine felt significantly more sedated at 0-24 h, but not at 24-48 h after operation, compared with patients who received placebo (P = 0.002 and P = 0.127, respectively). There were no significant differences in pain (VAS) at rest, during mobilization or cough, PCA morphine consumption, sensory block to pinprick, pressure pain detection threshold assessed with an algometer, touch and pain detection thresholds assessed with von Frey hairs, peak flow or side effects other than sedation. The power of detecting a reduction in VAS scores of 20 mm in our study was 80% at the 5% significance level. We conclude that we were unable to demonstrate an (additive) analgesic or opioid sparing effect of ketamine 10 mg h-1 i.v. combined with epidural bupivacaine at 0-24 h, or epidural morphine at 24-48 h after renal surgery. (+info)Neonatal outcome and mode of delivery after epidural analgesia for labour with ropivacaine and bupivacaine: a prospective meta-analysis. (5/1144)
In this prospective meta-analysis, we have evaluated the effect of epidural analgesia with ropivacaine for pain in labour on neonatal outcome and mode of delivery compared with bupivacaine. In six randomized, double-blind studies, 403 labouring women, primigravidae and multiparae, received epidural analgesia with ropivacaine or bupivacaine 2.5 mg ml-1. The drugs were administered as intermittent boluses in four studies and by continuous infusion in two. Apgar scores, neurological and adaptive capacity scores (NACS), degree of motor block and mode of delivery were recorded. The studies were designed prospectively to fit meta-analysis of the pooled results. Results showed similar pain relief and consumption of the two drugs. In the vaginally delivered neonates, NACS scores were approximately equal for both groups at 2 h, but at 24 h there were fewer infants with NACS less than 35 in the ropivacaine compared with the bupivacaine group (2.8% vs 7.6%; P < 0.05). Spontaneous vaginal deliveries occurred more frequently overall with ropivacaine than with bupivacaine (58% vs 49%; P < 0.05) and instrumental deliveries (forceps and vacuum extraction) less frequently (27% vs 40%; P < 0.01), while the frequency of Caesarean section was similar between groups. The intensity of motor block was lower with ropivacaine. There were no significant differences in adverse events. (+info)Incidence of bradycardia during recovery from spinal anaesthesia: influence of patient position. (6/1144)
We administered 0.5% plain bupivacaine 4 ml intrathecally (L2-3 or L3-4) in three groups of 20 patients, according to the position in which they were nursed in the post-anaesthesia care unit (PACU): supine horizontal, 30 degrees Trendelenburg or hammock position (trunk and legs 30 degrees elevated). Patients were observed until anaesthesia descended to less than S1. The incidence of severe bradycardia (heart rate < 50 beat min-1) in the PACU was significantly higher in patients in the Trendelenburg position (60%) than in the horizontal (20%, P < 0.01) or hammock (10%, P < 0.005) position. After 90 min, following admission to the PACU, only patients in the hammock position did not have severe bradycardia. In this late phase, the incidence of severe bradycardia in the Trendelenburg group was 35% (P < 0.005) and 10% in patients in the supine horizontal position. In four patients, severe bradycardia first occurred later than 90 min after admission to the PACU. The latest occurrence of severe bradycardia was recorded 320 min after admission to the PACU. We conclude that for recovery from spinal anaesthesia, the Trendelenburg position should not be used and the hammock position is preferred. (+info)Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. (7/1144)
We studied 32 patients undergoing bilateral symmetrical lower third molar surgery under general anaesthesia to determine if the combined effects of pre-emptive local anaesthetic block using 0.5% bupivacaine, together with i.v. tenoxicam and alfentanil had any benefits over postoperative administration. Patients acted as their own controls and were allocated randomly to have surgery start on one side, the second side always being the pre-emptive side. Difference in pain intensity between the two sides was determined using visual analogue scales completed by each individual at 6 h, and at 1, 3 and 6 days after operation. A long-form McGill pain questionnaire was also used to assess difference in pain intensity between the two sides on the morning after surgery. There was no significant difference in pain intensity at any time after surgery. Our findings indicate that the combined use of pre-emptive analgesia from 0.5% bupivacaine, tenoxicam and alfentanil did not reduce postoperative pain intensity in patients undergoing molar exodontia. (+info)Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. (8/1144)
BACKGROUND: The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to assess the relative analgesic potencies of epidural bupivacaine and ropivacaine by determining their respective minimum local analgesic concentrations. METHODS: Seventy-three parturients at < or = 7 cm cervical dilation who requested epidural analgesia were allocated to one of two groups in this double-blinded, randomized, prospective study. After a lumbar epidural catheter was placed, 20 ml of the test solution was given, either ropivacaine (n = 34) or bupivacaine (n = 39). The concentration of local anesthetic was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. Analgesic efficacy was assessed using 100-mm visual analog pain scores with < or = 10 mm within 30 min defined as effective. An effective result directed a 0.01% wt/vol decrement for the next patient. An ineffective result directed a 0.01% wt/vol increment. RESULTS: The minimum local analgesic concentration of ropivacaine was 0.111% wt/vol (95% confidence interval, 0.100-0.122), and the minimum local analgesic concentration of bupivacaine was 0.067% wt/vol (95% confidence interval, 0.052-0.082). Ropivacaine was significantly less potent than bupivacaine, with a potency ratio of 0.6 (95% confidence interval, 0.49-0.74). No difference in motor effects was observed. CONCLUSION: Ropivacaine was significantly less potent than bupivacaine for epidural analgesia in the first stage of labor. (+info)
In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...
Comparative antibacterial activity of synthetic N,S-Heterocyclic derivatives, MgO nanoparticles, and glycine on zoonotic Vibrio...
Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...
Minimum analgesic concentration of bupivacaine after continuous epidural infusion following spinal anesthesia in the...
A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...
Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor - Full Text View - ClinicalTrials.gov
Continuous infusion bupivacaine via an elastomeric pump
Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine,...
Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...
Bupivacaine Injection of Eye Muscles to Treat Strabismus - Full Text View - ClinicalTrials.gov
Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...
Bupivacaine hydrochloride,monohydrate,usp - Alfa Chemistry
99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik
Levobupivacaine - Wikipedia
Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2
Journal of Anaesthesiology Clinical Pharmacology
HTX-011 | Heron Therapeutics
Cook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited Store
Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...
Bupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response...
Episode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC Podcast
FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists
- The...
Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: Inversion of postoperative pain relief efficacy. |...
Combined Spinal and General Anesthesia Attenuates Liver Metastasis by Preserving Th1/Th2 Cytokine Balance | Anesthesiology |...
A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...
Brazilian Journal of Anesthesiology - Volume 59 / Issue 3
Bupivacaine-induced myocardial depression and pulmonary edema:...
Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.
Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
Bupivacaine implant - Innocoll - AdisInsight
Bupivacaine Inhibits Activation of Neuronal Spinal Extracellular Receptor-activated Kinase through Selective Effects on...
Bupivacaine & Adrenaline 0.5% - Drugs.com
Update on the clinical utility and practical use of ropivacaine in Chi | DDDT
June 21, 2020 - Food & Beverage Herald
Sabinet | Clinical trial: Bupivicaine hydrochloride in the treatment of sports injuries
Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLink
Buffered bupivacaine : Hulu ip address
Postoperative - ESRA
Anesthetics, Local
-
Catalog
Company Overview | Heron Therapeutics
2019 ASHP Midyear
Bupivacaine | The Chopra Library
Post-cesarean Section Analgesic Safety and Efficacy of EXPAREL (Liposomal Bupivacaine) Infiltration Locally Versus Transversus...
The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study | BMC Musculoskeletal...
Influence of Voltage-sensitive Ca++Channel Drugs on Bupivacaine Infiltration Anesthesia in Mice | Anesthesiology | American...
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial | American Journal of...
Ropivacaine - Wikipedia
Tramadol as adjunct to psoas compartment block with levobupivacaine 0.5%: a randomized double-blinded study.
Bupivacaine Hcl Introduction | acridinek
Local Anesthetics Are Off-Label For Spinals | RK.md
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry - Sleep and...
Sphenopalatine Ganglion (SPG) Blocks | SPG Blocks | Chicago
Headache, Migraine, Fibromyalgia and TMJ Treatment with Sphenopalatine Ganglion Blocks and Neuromuscular Dentistry -...
Bupivacaine Field Block With Clonidine for Postoperative Pain Control in Posterior Spine Approaches by Congress of Neurological...
Comparison of Tramadol and Buprinorphine as an Adjuvent to Bupivacaine used in Supraclavicular brachial plexus block for upper...
Rapid chiral separation and impurity determination of ropivacaine and bupivacaine by Densitometry-HPTLC, using...
Is continuous perineural stump infusion of bupivacaine effective on acute and chronic postoperative stump pain? Could it reduce...
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR...
Effects of bupivacaine and lidocaine on mitochondrial respiration and ATP synthesis]. - Semantic Scholar
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site
Comparison of low dose dexmedetomidine and clonidine as additives to bupivacaine in ultrasound directed supraclavicular blocks...
Bupivacaine/hydromorphone Drug Interactions - Drugs.com
The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery - ICH GCP - Clinical...
PWE-399 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer | Gut
News Release - Investors - Pacira Pharmaceuticals, Inc.
Anesthesia, Epidural | The Chopra Library
Particulate Matter Triggers Hospira Recall of Injection
Local Anesthetic Switching for Intrathecal Tachyphylaxis in... : Anesthesia & Analgesia
ClinMed International Library
Local Anesthetic Toxicity Differential Diagnoses
Bupivacaine Liposome (Injection Route) Precautions - Mayo Clinic
Papers with the keyword epiphisiodesis | Read by QxMD
Hospira, Inc. Articles, Photos, and Videos - CT Now
Products | Pacira
Article abstract | Medical Science Monitor
Eagles-Cowboys up-down drill
Overview: The Communication Initiative | The Digital and Development Network
Staff Changes
Anaesthesia-Intensive care.com: RENAL FAILURE INVESTIGATION
Anaesthesia-Intensive care.com: NHS works
Potassium channel
Pipecolic acid
DNA vaccination
Combined spinal and epidural anaesthesia
Anaesthesia for ocular surgery
Veterinary surgery
Pudendal nerve entrapment
Bupivacaine 25mg/10ml (0.25%) inj ampoules | LloydsPharmacy
Comparison of bupivacaine and fentanyl as an adjuvant of epidural morphine for postoperative analgesia | SpringerLink
Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes | Circulation
Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. | Sigma...
Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
Phenomenex HPLC Application #17309: Bupivacaine on Lux Cellulose-2
Bupivacaine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Effect of Morphine and Bupivacaine on Nicotine-Induced Catecholamine Secretion from Encapsulated Chromaffin Cells
Bupivacaine impurity B (2RS)-N-(2,6-dimethylphenyl)piperidine-2-carboxamide- CAS Number 65797-42-4
FDA Alert: Hospira Recalls Marcaine (Bupivacaine HCI Injection, USP) - The American Society of Retina Specialists
- The...
Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats |...
Bupivacaine hydrochloride,monohydrate,usp - Alfa Chemistry
Bupivacaine-induced myocardial depression and pulmonary edema:...
99% Kemurnian Bupivacaine Hydrochloride CAS 14252-80-3 untuk Analgesik
Comparative Study of Hernia Block with Bupivacaine Alone and Bupivacaine Plus Dexamethasone as Adjuvant for Open Hernia Repair...
A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of...
Publications of Faculty of Medicine:Abstract of Comparative Study of Neostigmine and Ketamine as Additives to Plain Bupivacaine...
Cook-Waite- Marcaine® 0.5% with Epinephrine 1:200,000 (bupivacaine), 50 1.7ml Carpules/Box - HANSAmed Limited Store
In vivo Comparison of the Effects of Bupivacaine and Levobupivacaine on the Pregnant Rat Myometrium Using Electrohysterogram |...
Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response...
A clinical study of labour using epidural analgesia with 0.125% bupivacaine and its outcome | INTERNATIONAL JOURNAL OF CURRENT...
Comparative Evaluation of Intrathecal Dexmedetomidine and Fentanyl with Hyperbaric Bupivacaine for Post-Operative Analgesia in...
2019 ASHP Midyear
Prospect MARCAINE, solutie injectabila | eProspect.ro
Episode 147: Lower Extremity Nerve Blocks Part 2: Front of Leg - ACCRAC Podcast
June 21, 2020 - Food & Beverage Herald
Analgesia0.25SpinalLevobupivacaineEffects of bupivacaineLidocaineMorphineMarcaineSignificantlyAnesthesiaSalineDoseAnestheticsMixtureAbstractDexmedetomidineSodiumContinuousBlockadeAdrenalinePainLocalEpiduralEpinephrineLidocaineIntrathecal bupivacaineLiposome injectableAnalgesiaFentanylInjected with liposomal bupivacaineToxicityExtended-release bupivacaineSuppressed bupivacaine-inducedAnalgesicInjection of bupivacaineContraindicated in patients withConcentrationsAnestheticBrachial plexus blockDose of hyperbaric bupivacaineRacemic0.75Side effects of bupivacaineAmideEfficacy of liposomalLiposomal bupivacaine infiltrationDosesSpinal anaesthesiaSurgicalIntra-articularCardiotoxicMedicationForms of bupivacaineIndicate that bupivacaineFormulations of BupivacaineEffectivenessHypotensionFormulationPeripheralApoptosisContains bupivacaineDouble-blind randomized studyPatientsSurgery
Analgesia2
- We conducted a retrospective study to determine whether bupivacaine or fentanyl is a better adjuvant to epidural morphine for postoperative analgesia using 108 patients. (springer.com)
- Conclusion: Levobupivacaine led to less muscle relaxation compared to bupivacaine and may be a better option for labor analgesia and anesthesia considering uterine contractility. (medeniyet.edu.tr)
0.251
- In practice 3 X 10 ml ampoules of bupivacaine 0.25 solution with adrenaline 1 200 000 are admixed with 3 X 10 ml ampoules of 1 ligno-caine to produce 3 X 20 ml. (ormedmedical.us)
Spinal1
- Bupivacaine is a prescription medication used to prevent pain and induce spinal anesthesia. (rxwiki.com)
Levobupivacaine4
- We aimed to compare the effects of bupivacaine and levobupivacaine on rat uterine contractility in an in vivo setting. (medeniyet.edu.tr)
- Methods: Electrical activities of 40 pregnant rat uteruses were recorded on electrohysterogram after dividing the rats into bupivacaine and levobupivacaine groups. (medeniyet.edu.tr)
- The first 5-min recording was considered the control, which was immediately followed by intramyometrial administration of either bupivacaine or levobupivacaine. (medeniyet.edu.tr)
- Levobupivacaine is a long-acting local anesthetic agent belonging to the amido amine group, it is basically an S-enantiomer of bupivacaine drug. (fnbherald.com)
Effects of bupivacaine1
- Central nervous system and cardiovascular toxicity are well-known side effects of bupivacaine. (mysciencework.com)
Lidocaine1
- DYURAL 80 KIT- methylprednisolone acetate, lidocaine hydrochloride, bupivacaine hydrochloride, povidine iodine, sodium chloride, isopropyl alcohol Asclemed USA, Inc. Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. (atarax-hydroxyzine.com)
Morphine4
- In conclusion, fentanyl appears to be a better adjuvant to epidural morphine than bupivacaine. (springer.com)
- Effect of Morphine and Bupivacaine on. (scientific.net)
- Therefore, the present study investigated the effect of morphine or bupivacaine on the secretion of nicotine-induced CAs from encapsulated chromaffin cells over a period of 180 min. (scientific.net)
- The capsules were then pre-incubated with nicotine for 5 min prior to morphine or bupivacaine stimulation, and the quantity of CAs analyzed using a high performance liquid chromatography (HPLC) analysis system. (scientific.net)
Marcaine2
- Marcaine 2,5 mg/ml: 60 ml (150 mg bupivacaine hydrochloride). (eprospect.ro)
- Descriere: Marcaine (bupivacaine) este un anestezic local de tip amidic, cu durata lunga de actiune si eficacitate anestezica ridicata (Vezi si Marcaine adrenalina). (eprospect.ro)
Significantly1
- However, cellular levels of p62 protein were significantly increased upon bupivacaine treatment (1.29 ± 0.15 vs. 1.00 ± 0.15), suggesting that the drug impaired autophagosome clearance. (sigmaaldrich.com)
Anesthesia1
- Bupivacaine injection should not be used in obstetrical paracervical block (local anesthetic injection around cervix) anesthesia. (rxwiki.com)
Saline1
- Women received either 15 ml of 0.9% saline (n=42) or 15 ml of 0.5% bupivacaine (n=43), which was instilled intraperitoneally. (elsevier.com)
Dose1
- HTX-011, a fixed-dose combination of the local anesthetic bupivacaine with the nonsteroidal anti-inflammatory drug (NSAID) meloxicam being investigated for application into the surgical site to reduce postoperative pain and the need for opioid analgesics for 72 hours. (jspargo.com)
Anesthetics2
- Bupivacaine belongs to a group of drugs called local anesthetics. (rxwiki.com)
- Currently many cancer patients receive general opioids or local anesthetics, such as bupivacaine. (scientific.net)
Mixture2
- The recommended local anaesthetic agent is a mixture of bupivacaine and lignocaine with the addition of adrenaline 1 200 000. (ormedmedical.us)
- The benefits of this mixture are the rapid onset of action of the lignocaine solution, the prolonged action of the bupivacaine and the possibility of reduced local haemorrhage with the addition of adrenaline. (ormedmedical.us)
Abstract1
- abstract = "The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. (elsevier.com)
Dexmedetomidine1
- This study could not demonstrate a benefit of administering bupivacaine with dexmedetomidine or buprenorphine in cats. (bmj.com)
Sodium1
- These findings suggest myocardial depression owing to bupivacaine sodium channel blocking of myocardial nerve and tissue and subsequent reduction of myocardial contractility. (mysciencework.com)
Continuous1
- Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response and pulmonary function following cholecystectomy. (regionh.dk)
Blockade1
Adrenaline1
- Bupivacaine & Adrenaline 0.5% may be available in the countries listed below. (drugs.com)
Pain1
- Twenty patients undergoing elective cholecystectomy were prospectively randomised to receive either intrapleural (bolus 20 ml followed by 10 ml/h) or thoracic epidural (bolus 9 ml followed by 5 ml/h) bupivacaine 0.5% for 8 h postoperatively to assess the effect of these two techniques on pain, pulmonary function and the surgical stress response. (regionh.dk)
Local2
- Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. (sigmaaldrich.com)
- Bupivacaine is used as a local or regional anesthetic for various procedures. (rxwiki.com)
Epidural18
- Concentrated bupivacaine is not recommended for epidural freezing. (wikipedia.org)
- Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. (wikipedia.org)
- Bupivacaine has caused several deaths when the epidural anaesthetic has been administered intravenously accidentally. (wikipedia.org)
- Bupivacaine is given as an epidural injection into the spinal column to produce numbness during labor, surgery, or certain medical procedures. (cigna.com)
- For an epidural, bupivacaine is given as an injection through a needle placed into an area of your middle or lower back near your spine. (cigna.com)
- Bupivacaine-fentanyl is a narcotic analgesic combination medication used to treat pain, often through an epidural administration. (patientslikeme.com)
- We conducted a retrospective study to determine whether bupivacaine or fentanyl is a better adjuvant to epidural morphine for postoperative analgesia using 108 patients. (springer.com)
- In conclusion, fentanyl appears to be a better adjuvant to epidural morphine than bupivacaine. (springer.com)
- This study aimed at comparing racemic bupivacaine and levobupivacaine in epidural anesthesia for elective cesarean section. (scielo.br)
- Fifteen minutes after epidural anesthesia, 62.5% of levobupivacaine group patients experienced Bromage 2 or 3 motor block, whereas the same event was documented in 72.7% of bupivacaine group patients (p = 0.83). (scielo.br)
- Levobupivacaine and bupivacaine were equally effective for epidural block in patients undergoing cesarean section. (scielo.br)
- Currently, most common drug for obstetric epidural anesthesia is bupivacaine. (scielo.br)
- A clinical comparison of compounded solution (2% xylocaine & 0.5% bupivacaine) with 0.5% bupivacaine in epidural analgesia. (thefreelibrary.com)
- The commonly used drugs for epidural analgesia are 2% xylocaine and 0.5% bupivacaine. (thefreelibrary.com)
- Epidural solutions containing combinations of bupivacaine hydrochloride and fentanyl citrate are commonly administered in the labor and delivery and postoperative settings for pain control. (ijpc.com)
- Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia. (ac.be)
- Reference : Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mi. (ac.be)
- en] Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. (ac.be)
Epinephrine16
- The rate of systemic absorption of bupivacaine and other local anesthetics is dependent upon the dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the preparation. (wikipedia.org)
- If you have an allergy to bupivacaine, epinephrine, or any other part of this drug. (mskcc.org)
- However, we and others ( 3 ) believe the rapid return of normal rhythm and hemodynamics in both dogs and rats following massive bupivacaine overdose (twice the dose used in Mayr's study), indicates superior efficacy of lipid rescue for bupivacaine toxicity to drugs, such as epinephrine and vasopressin that are components of the generic ACLS protocol for cardiopulmonary arrest ( 4 ). (lww.com)
- Perhaps Dr. Mayr will consider comparing combined epinephrine/vasopressin with lipid rescue in the porcine model of bupivacaine cardiac toxicity. (lww.com)
- Fresenius Kabi has bupivacaine and epinephrine on shortage due to increased demand and manufacturing delays. (ashp.org)
- Pfizer has bupivacaine with epinephrine on shortage due to manufacturing delays. (ashp.org)
- Fore Pharma has released its new research, Bupivacaine / Epinephrine Sales, Price Analysis, & Sales Forecast - 2017. (reportlinker.com)
- Find out the sales of Bupivacaine / Epinephrine worldwide and by countries in North America, Europe, Japan, BRIC, and Australia. (reportlinker.com)
- Discover the growth trends of Bupivacaine / Epinephrine by countries, and also find out sales forecast until 2021. (reportlinker.com)
- The research also provides Bupivacaine / Epinephrine unit price by countries. (reportlinker.com)
- The sales and price data from this report is useful for analyzing Bupivacaine / Epinephrine sales trends, sales forecast for Bupivacaine / Epinephrine, brand planning, Bupivacaine / Epinephrine generics trends, product positioning, strategic forecasts, BD&L, competitive intelligence, pricing analysis, and price benchmarks. (reportlinker.com)
- Patients were assigned to receive either 20 mL of 0.5% racemic bupivacaine or 20 mL of 0.5% levobupivacaine, both with 10 µg sufentanil and epinephrine 1:200,000. (scielo.br)
- Randomized trial of intraoperative intercostal block with bupivacaine with epinephrine compared to lipossomal extended release bupivacaine. (bioportfolio.com)
- Spinal analgesia during labor with low-dose bupivacaine, sufentanil, and epinephrine. (biomedsearch.com)
- Bupivacaine is commercially available as a racemic mixture of R(+) and S(-) enantiomers and it was first used in spinal blocks in concentrations of 0.5%, 0.75%, and 1%, with or without epinephrine 1 . (scielo.br)
- Local anesthetics also bind beta-adrenergic receptors and inhibit epinephrine-stimulated cAMP formation, which can explain the refractoriness of bupivacaine CV toxicity to standard resuscitation guidelines. (statpearls.com)
Lidocaine7
- Liposomal Bupivacaine vs. Bupivacaine Hydrochloride with Lidocaine During Midurethral Sling Placement: a Randomized Controlled Trial. (bioportfolio.com)
- The primary objective was to study the effects of liposomal bupivacaine (LB) compared to bupivacaine HCL with lidocaine on postoperative day 1 pain scores. (bioportfolio.com)
- A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. (bioportfolio.com)
- 4 In addition, lidocaine (Xylocaine) may offer a wider margin of safety than bupivacaine and may be the preferred agent in these cases. (aafp.org)
- 4. Stolik-Dollberg OC, Dollberg S. Bupivacaine versus lidocaine analgesia for neonatal circumcision. (aafp.org)
- After the test block with lidocaine (2%, 0.5 ml), a solution of tetracaine (20 mg) dissolved in bupivacaine (0.5%, 0.5 ml) was injected. (deepdyve.com)
- Do not mix with lidocaine or other non-bupivacaine-based local anesthetics. (clinicalpainadvisor.com)
Intrathecal bupivacaine7
- To determine the effective dose 50% (ED50) and the effective dose 95% (ED95) of intrathecal bupivacaine associated with opioids in the cesarean section of morbidly obese patients. (thefreedictionary.com)
- sup], However, to the best of our knowledge, few previous studies have determined the ideal dose of intrathecal bupivacaine when coadministered with sufentanil for cesarean delivery in severely preeclamptic parturients so far. (thefreedictionary.com)
- Effect of Long-Term Intrathecal Bupivacaine Infusion on Blood Pressure. (bioportfolio.com)
- OBJECTIVE: We aimed to investigate the efficacy of either plain or hyperbaric solutions of intrathecal bupivacaine and ropivacaine on maternal block characteristics, complications, side effects and neonatal parameters to find out which is superior in a single study. (biomedsearch.com)
- A randomised, double-blind comparison of three different volumes of hypobaric intrathecal bupivacaine for orthopaedic surgery. (thefreelibrary.com)
- We studied the effect of three different doses of oral clonidine on surgeries below umbilicus which were administered intrathecal bupivacaine. (omicsonline.org)
- All these issues have led to great number of research studies tested many different ways to reduce the incidence of hemodynamic instability through decreasing the intrathecal bupivacaine dosage by adding other drugs to it [ 10 ]. (alliedacademies.org)
Liposome injectable4
- November 12, 2018 -- The ADA has created a new Code on Dental Procedures and Nomenclature (CDT) for Exparel, a bupivacaine liposome injectable suspension from Pacira Pharmaceuticals . (drbicuspid.com)
- Neurotoxicity of intraneural injection of bupivacaine liposome injectable suspension versus bupivacaine hydrochloride in a porcine model. (bioportfolio.com)
- To test whether neurotoxic effects of a bupivacaine liposome injectable suspension differ from those of a standard formulation of bupivacaine hydrochloride (HCl) after intraneural injection into the s. (bioportfolio.com)
- This alert is being issued to inform health professionals about a potential medication safety issue with Exparel (bupivacaine liposome injectable suspension): wrong route of administration errors if the drug is confused with propofol. (ismp.org)
Analgesia12
- XaraColl®, a collagen-based implant that delivers bupivacaine to the site of surgical trauma, is under development for postoperative analgesia. (dovepress.com)
- The use of liposomal bupivacaine, compared with use of bupivacaine HCl, following gynecologic surgery decreased the need for narcotics and reduced the use of patient-controlled analgesia. (obgyn.net)
- Still, the data pointed to a reduction in use of patient-controlled analgesia among those who were treated with liposomal bupivacaine (1.4% vs 8.3%, P=.05). (obgyn.net)
- This was also found among women who underwent cytoreductive surgeries, with 4.1% of the women treated with liposomal bupivacaine using patient-controlled analgesia compared with 33.3% of women in the control group. (obgyn.net)
- Conclusion: The present study demonstrates that addition of 20 mg nalbuphine to bupivacaine in supraclavicular brachial plexus block is associated with significant increase in the duration of both sensory and motor block and also prolong the duration of analgesia. (scirp.org)
- Liposomal bupivacaine was developed for injection at the surgical site with the potential for extended analgesia. (healio.com)
- Multiple studies have reported successful results and improvement in postoperative analgesia with liposomal bupivacaine. (healio.com)
- Bupivacaine is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (asahq.org)
- Does Continuous Wound Infusion of 0.2% Bupivacaine Provide Superior Analgesia Compared to Standard Opioid-based Therapy in Patients Following Axillary Clearance Surgery? (knowcancer.com)
- Hower, despite incorporating more data in the analysis, we found little evidence that the need for conversion to general anaesthesia and supplemental analgesia differed between the hyperbaric or isobaric bupivacaine groups. (cochrane.org)
- The duration of analgesia and comparative efficacy of liposomal bupivacaine and an elastomeric bupivacaine pump in a diverse surgical population were determined" Kenes et al (2015). (ivteam.com)
- This prospective, randomized comparative study was conducted to compare the onset time of sensory block, onset time of motor block and time to achieve complete block, duration of analgesia adding fentanyl with bupivacaine-lignocaine mixtures in supraclavicular brachial plexus block. (banglajol.info)
Fentanyl15
- The prospective randomized study was conducted to compare the analgesic efficacy of dilute concentration of bupivacaine and ropivacaine with fentanyl. (thefreedictionary.com)
- What is Bupivacaine-Fentanyl? (patientslikeme.com)
- No patients have reported taking Bupivacaine-Fentanyl. (patientslikeme.com)
- There are no evaluations for Bupivacaine-Fentanyl. (patientslikeme.com)
- Eighty patients were prospectively randomised to receive plain 1.5 ml levobupivacaine 0.5% (group levobupivacaine) or 1.5 ml plain bupivacaine 0.5% (group bupivacaine) in combination with fentanyl 0.3 ml (15 microg) for spinal anaesthesia. (biomedsearch.com)
- Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section. (biomedsearch.com)
- METHODS: One hundred and three term parturients were randomly assigned to receive intrathecal 10 mg hyperbaric bupivacaine (Group Bh), 10 mg plain bupivacaine (Group Bp), 15 mg hyperbaric ropivacaine prepared with dextrose 30% (Group Rh) or 15 mg plain ropivacaine (Group Rp) coadministered with fentanyl 20 μg. (biomedsearch.com)
- The aim of this study was to evaluate analgesic effects of Bupivacaine (marcaine), Bupivacaine plus midazolam, and Bupivacaine plus fentanyl in reducing pain after knee arthroscopic surgery. (magiran.com)
- Group A, B and C received Bupivacaine (50 mg), Bupivacaine (50 mg) plus midazolam (50 μg/kg), and Bupivacaine (50 mg) plus fentanyl (3 μg/kg), respectively. (magiran.com)
- The spinal regimen was 5 mg bupivacaine heavy 0,5% combined with 50 mcg fentanyl. (omicsonline.org)
- Low dose spinal anesthesia using 5 mg of bupivacaine heavy 0,5% and adjuvant opioid fentanyl 50 mcg can be successfully used for the performance of CS delivery as regards to onset, adequacy, level, duration of the block and hemodynamic stability and good fetal outcome, with impressive cardiovascular stability. (omicsonline.org)
- Evaluation of analgesic efficacy of intra-articular bupivacaine, bupivacaine plus fentanyl, and bupivacaine plus tramadol after arthroscopic knee surgery. (druglib.com)
- PURPOSE: To compare the efficacy of intra-articular (IA) bupivacaine, bupivacaine-fentanyl, and bupivacaine-tramadol for relief of postoperative pain after arthroscopic knee surgery. (druglib.com)
- CONCLUSIONS: On the primary outcome measure (VAS pain score), both bupivacaine with fentanyl and bupivacaine with tramadol were better than IA bupivacaine, and bupivacaine with fentanyl was better than that with tramadol. (druglib.com)
- Thus IA bupivacaine-fentanyl appears to be the best combination for relief of postoperative pain in patients undergoing arthroscopic knee surgery, followed by IA bupivacaine-tramadol. (druglib.com)
Injected with liposomal bupivacaine1
- After surgical sperm retrieval, the wound will be injected with liposomal bupivacaine (266 mg) mixed with standard bupivacaine (bupivacaine hydrochloride 50mg) for post-operative pain relief. (clinicaltrials.gov)
Toxicity5
- a lipid infusion such as propofol increases the dose of bupivacaine required to induce cardiac arrest, and, therefore, this strategy has been suggested as a potential means to improve outcomes from such toxicity. (lww.com)
- The higher potency of R (+)-bupivacaine to block the inactivated state of the cardiac Na + channel may explain its higher toxicity because of the large contribution of the inactivated-state block during the plateau phase of the cardiac action potential. (ahajournals.org)
- A serum bupivacaine concentration, obtained 2.5 hours after injection, was 0.76 mcg per mL, which is consistent with previous reports of bupivacaine toxicity 1 and higher than bupivacaine concentrations reported in older boys after circumcision. (aafp.org)
- 6 This case exemplifies the principle that relatively small volumes of bupivacaine may result in local anesthetic toxicity. (aafp.org)
- Acute bupivacaine toxicity as a result of venous leakage under the tourniquet cuff during a Bier block. (aafp.org)
Extended-release bupivacaine6
- Patients treated with extended-release bupivacaine also used less narcotic rescue medication, spent less time in the hospital, and had fewer falls than those treated with femoral nerve block. (medscape.com)
- Dr. Emerson and his colleague, John Barrington, MD, from the Texas Center for Joint Replacement in Plano, presented results from 2 cohorts of patients treated with extended-release bupivacaine here at the American Academy of Orthopaedic Surgeons 2014 Annual Meeting. (medscape.com)
- The extended-release bupivacaine cut the number of falls from 10 to 2 and saved $1246 per patient. (medscape.com)
- 36 patients received extended-release bupivacaine and 36 received femoral nerve block. (medscape.com)
- There were no adverse reactions to the extended-release bupivacaine, Dr. Emerson reported. (medscape.com)
- Extended-release bupivacaine "has been an absolute game-changer as far as the control of pain," said Charles Lowry Barnes, MD, professor of orthopedics at the University of Arkansas in Little Rock. (medscape.com)
Suppressed bupivacaine-induced1
- GB suppressed bupivacaine-induced mitochondrial depolarization and mitochondria complex I and III inhibition and increased cleaved caspase-3 and Htra2 expression, which was strongly indicative of activation of mitochondria-dependent apoptosis with concomitantly enhanced expressions of Grp78, caspase-12 mRNA, protein, and ER stress. (hindawi.com)
Analgesic4
- Bupivacaine application is effective in decreasing postoperative pain and analgesic requirement during the hospital stay for patients with thyroidectomy. (springer.com)
- The local anesthetic bupivacaine is a common analgesic adjuvant medication used in combination with opioids in intrathecal drug delivery systems (IDDSs). (bioportfolio.com)
- Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochloride encapsulated within multiple, non-concentric lipid bi-layers offering a novel method of sustained release. (cochrane.org)
- To assess the analgesic efficacy and adverse effects of liposomal bupivacaine infiltration peripheral nerve block for the management of postoperative pain. (cochrane.org)
Injection of bupivacaine2
- In the bupivacaine group, an intraoperative extended-release liposome injection of bupivacaine 266 mg was administered at the end of surgery. (medscape.com)
- However, accidental intravascular injection of bupivacaine can produce severe arrhythmias and cardiac depression. (ahajournals.org)
Contraindicated in patients with1
- Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. (wikipedia.org)
Concentrations4
- Concentrations of bupivacaine greater than 0.5% are contraindicated for this purpose in view of reports of cardiac arrest and maternal death. (who.int)
- SH-SY5Y cells were treated with different concentrations of bupivacaine alone or following preincubation with GB. (hindawi.com)
- At concentrations lower than 40 microM (concentrations encountered in clinical situations), the low capacity, high affinity apparent site was predominant and S(-)-bupivacaine exhibited a higher free fraction than R(+)-bupivacaine. (aspetjournals.org)
- Human articular chondrocytes were exposed to equal and equipotent concentrations of bupivacaine, ropivacaine, and mepivacaine for 1 hour. (ovid.com)
Anesthetic17
- NEW ORLEANS - The extended-release formulation of the local anesthetic bupivacaine is just as effective as a femoral nerve block for relieving pain after total knee replacement surgery, new research shows. (medscape.com)
- They will be assigned to either TAP block with the liposomal bupivacaine solution or to traditional preincisional local anesthetic with bupivacaine alone. (thefreedictionary.com)
- Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body. (cigna.com)
- Bupivacaine is used as a local (in only one area) anesthetic. (cigna.com)
- Bupivacaine is also used as an anesthetic for dental procedures. (cigna.com)
- The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. (nih.gov)
- A local anesthetic with rapid onset and long action, similar to BUPIVACAINE. (bioportfolio.com)
- We tested the neuroprotective efficacy of ginkgolide B (GB), an active component of Ginkgo biloba, against ROS-mediated neurotoxicity caused by the local anesthetic bupivacaine. (hindawi.com)
- Local anesthetic bupivacaine is found in two different enantiomers: levobupivacaine - S (-) and dextrobupivacaine - R (+). Based on studies showing that S(-) enantiomers are less cardiotoxic, their use has been increasing in clinical practice. (scielo.br)
- The study is a drug trial comparing the post-operative pain control provided by liposomal bupivacaine (a local anesthetic) against standard bupivacaine (a different formulation of the local anesthetic) for men undergoing testicular sperm extraction. (clinicaltrials.gov)
- Investigation into spinal anesthetic failure with hyperbaric bupivacaine: the role of cold exposure on bupivacaine degradation. (bioportfolio.com)
- Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts. (sigmaaldrich.com)
- Bupivacaine is used as a local or regional anesthetic for various procedures. (rxwiki.com)
- The anesthetic action of S(-)-bupivacaine, R(+)-bupivacaine and ropivacaine was directly compared in vitro by studying their effects on action potential and the maximum value of dV/dt (dV/dt max) in crayfish giant axon. (nii.ac.jp)
- Publications] Kanai Yuko, Katsuki Hiroshi and Takasaki Mayumi: 'Comparison of anesthetic effect of bupivacaine and ropivacaine. (nii.ac.jp)
- Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated (BK/SK) K+ channels and N-type voltage-gated (Kv1/shaker and Kv3 KCNA/KCNC) K+ channels. (lktlabs.com)
- Bupivacaine is a potent local anesthetic with unique characteristics from the amide group of local anesthetics, first discovered in 1957. (statpearls.com)
Brachial plexus block2
- Results published in Orthopedics showed similar efficacy between injectable liposomal bupivacaine and an interscalene brachial plexus block among patients who underwent total shoulder arthroplasty. (healio.com)
- Patients and Methods: Fifty-six patients under- going elective forearm and hand surgery under supraclavicular brachial plexus block were allocated randomly into one of two groups of 28 patients each to receive either 25 ml (0.5%) bupivacaine with 1 ml of NS or 25 ml (0.5%) bupivacaine with 1 ml (20 mg) nalbuphine. (scirp.org)
Dose of hyperbaric bupivacaine1
- When haemodynamic change was compared between bilateral and unilateral spinal block from the same dose of hyperbaric bupivacaine (8 mg), the frequencies of hypotension were 22.4% and 5%, respectively (2). (thefreelibrary.com)
Racemic3
- Hyperbaric bupivacaine is commercially available in its racemic form. (scielo.br)
- Separation of racemic bupivacaine allows the production of the levorotatory and dextrorotatory enantiomers. (scielo.br)
- Background : Levobupivacaine and ropivacaine are both single S(-)-enantiomers that have less cardiotoxic and convulsant effects than racemic bupivacaine. (nii.ac.jp)
0.752
- A "heavy" solution (0.75% bupivacaine in 8.25% glucose) will provide the muscular relaxation required for abdominal surgery. (who.int)
- An expanded recall was issued on August 29, 2013 for one lot of 0.75% Bupivacaine HCl Injection, USP (7.5 mg/mL), 30 mL Single-dose Vial (NDC 0409-1165-02). (asahq.org)
Side effects of bupivacaine1
- What are the possible side effects of bupivacaine? (cigna.com)
Amide3
- Bupivacaine is related chemically and pharmacologically to the amide-type local anesthetics. (rxlist.com)
- Bupivacaine is an amide local anaesthetic used in hyperbaric and isobaric forms. (cochrane.org)
- All local anesthetics contain three structural components: an aromatic ring, a connecting group which is either an ester (procaine) or an amide (bupivacaine), and an ionizable amine group. (statpearls.com)
Efficacy of liposomal1
- In the study, which included about 400 surgical patients, researchers compared the efficacy of liposomal bupivacaine and bupivacaine hydrochloride (HCl) for controlling postoperative pain after laparotomy for gynecological malignancies. (obgyn.net)
Liposomal bupivacaine infiltration1
- This study aimed to evaluate the effect of liposomal bupivacaine infiltration on total amount of opioid use, incidence of AEs and length of stay (LOS) after minimally invasive (MIS) sigmoid coloctomy. (bmj.com)
Doses7
- Unsurprisingly, the researchers found that patients who received liposomal bupivacaine following complex cytoreductive surgery required significantly fewer doses of intravenous opioids during the first and second postoperative days than those whose pain was managed with bupivacaine HCl. (obgyn.net)
- This prospective, randomized, clinical study was performed in 80 patients who were assigned to four groups to receive different doses of intrathecal hyperbaric bupivacaine (5 mg, 7.5 mg, 10 mg and 12.5 mg in Groups 1, 2, 3, and 4 respectively). (dovepress.com)
- Unilateral sensory and motor block can be achieved with doses of 5 mg and 7.5 mg hyperbaric bupivacaine 0.5% with a stable hemodynamic state. (dovepress.com)
- He received two 1-mL doses of 0.5% bupivacaine, spaced apart by two to three minutes. (aafp.org)
- The primary objective of this randomised clinical study was to evaluate the frequency of unilateral block when different doses of hypobaric bupivacaine solution were used for single limb orthopaedic surgery. (thefreelibrary.com)
- The proposed study aims to investigate the effect of three different doses of oral clonidine on subarachnoid block, anxiolysis, sedation, hemodynamic stability and their side effects, in patients undergoing surgeries below umbilicus in order to find out its optimum dose as a premedication agent with spinal anaesthesia Bupivacaine . (omicsonline.org)
- Bupivacaine may be neurotoxic at high doses, activating p38 MAPK, increasing levels of ROS and WDR53, and inducing apoptosis in neuroblastoma cells. (lktlabs.com)
Spinal anaesthesia4
- This Cochrane Review summarizes the best available evidence for the effectiveness and safety of the denser form of bupivacaine compared to the isobaric form when spinal anaesthesia (injection of medications into the lower back) is used for delivery of a baby by caesarean section. (cochrane.org)
- We included all randomized controlled trials (RCTs) involving parturients undergoing spinal anaesthesia for elective caesarean section that compared the use of hyperbaric with isobaric bupivacaine. (cochrane.org)
- Preoperative oral clonidine 4 μg kg-1 appears to be the optimum dose for optimization of spinal anaesthesia with bupivacaine as it prolongs the sensory block maximally with minimal side effects. (omicsonline.org)
- Bupivacaine is the most common drug used in the spinal anaesthesia but its high dosage is associated with the increased incidence of hypotension [ 8 ]. (alliedacademies.org)
Surgical7
- At the time of closure of surgical incision, 20ml of bupivacaine 0. (thefreedictionary.com)
- Participants in this arm will have a single injection of liposomal bupivacaine admixed with standard bupivacaine (266mg liposomal bupivacaine mixed with 50mg bupivacaine hydrochloride) at the conclusion of their surgical sperm retrieval procedure. (clinicaltrials.gov)
- Participants in this arm will have a single injection of standard bupivacaine (100mg bupivacaine hydrochloride) at the conclusion of their surgical sperm retrieval procedure. (clinicaltrials.gov)
- Randomised, double- blind , placebo - or active-controlled clinical trials of a single dose of liposomal bupivacaine administered as a peripheral nerve block in adults aged 18 years or over undergoing elective surgery at any surgical site. (cochrane.org)
- XARACOLL is Innocoll's late-stage surgically implantable and bioresorbable collagen matrix developed to provide sustained postsurgical pain relief through controlled delivery of bupivacaine at the surgical site. (globenewswire.com)
- XARACOLL® is a surgically implantable and bioresorbable bupivacaine-collagen matrix that utilizes our CollaRx® proprietary collagen-based delivery technology and is being developed to provide sustained postsurgical pain relief directly into the surgical site. (globenewswire.com)
- Patients in the intervention group received 266mg of liposomal bupivacaine in the surgical incision by a single surgeon and were matched to controls for age, gender, BMI, procedure and extraction site. (bmj.com)
Intra-articular1
- Bupivacaine is toxic to cartilage and its intra-articular infusions may lead to postarthroscopic glenohumeral chondrolysis. (wikipedia.org)
Cardiotoxic2
- Levobupivacaine, the isolated S (-) enantiomer of Bupivacaine , has been shown to be less cardiotoxic than Bupivacaine in pre-clinical studies. (thefreedictionary.com)
- Bupivacaine is especially cardiotoxic. (openanesthesia.org)
Medication7
- Bupivacaine is available as a generic medication and is not very expensive. (wikipedia.org)
- Bupivacaine may also be used for purposes not listed in this medication guide. (cigna.com)
- This is a research study testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
- This is a research study of SABER® -Bupivacaine, an experimental medication designed to relieve pain up to 3 days after surgery. (bioportfolio.com)
- This is an extension to a previous research trial testing SABER™-Bupivacaine (an experimental pain-relieving medication). (bioportfolio.com)
- Bupivacaine added to liposomal bupivacaine addressed the delayed onset of this medication and gave an accurately matched comparison with the ropivacaine cocktail. (healio.com)
- In the case of bupivacaine, there are no specific foods that you must exclude from your diet when receiving this medication. (rxwiki.com)
Forms of bupivacaine1
- Not interchangeable with other forms of bupivacaine. (clinicalpainadvisor.com)
Indicate that bupivacaine2
- Conclusions Both the large level of pulse-dependent block and the failure of the pure inactivated-state block model indicate that bupivacaine interacts with the activated (or open) state of the cardiac sodium channel in addition to its block of the inactivated state. (ahajournals.org)
- These data indicate that bupivacaine is not transported through the brain capillary wall, i.e., the blood-brain barrier, from the bovine albumin-bound pool, but bupivacaine is partially available for transfer from the circulating AAG-bound pool. (aspetjournals.org)
Formulations of Bupivacaine2
- Different formulations of bupivacaine are not bioequivalent even if the milligram strength is the same. (rxlist.com)
- see Non-Interchangeability with Other Formulations of Bupivacaine ]. (rxlist.com)
Effectiveness1
- The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. (wiley.com)
Hypotension2
- In this study, we tried to solve this challenge by increasing the dose of bupivacaine to achieve a proper spinal level accompanied by prolonged sitting up to avoid hypotension. (nih.gov)
- Most common complication was hypotension, detected in 16 (66.7%) levobupivacaine group patients and in 10 (43.5%) bupivacaine group patients (p = 0.11). (scielo.br)
Formulation1
- Liposomal bupivacaine (LB) is Food and Drug Administration-approved extended-release formulation of bupivacaine for interscalene peripheral nerve blocks. (medworm.com)
Peripheral1
- We identified randomised trials of liposomal bupivacaine peripheral nerve block for the management of postoperative pain. (cochrane.org)
Apoptosis7
- These results implicate bupivacaine-induced ROS-dependent mitochondria, ER dysfunction, and apoptosis, which can be attenuated by GB through its antioxidant property. (hindawi.com)
- For example, bupivacaine may inhibit mitochondrial respiratory complexes I and III, leading to decreased ATP production, collapse of the mitochondrial membrane potential (Δ ψ m), overproduction of reactive oxygen species (ROS), and ultimately liberation of cytochrome c and activation of the caspase-3-dependent apoptosis pathway [ 10 - 12 ]. (hindawi.com)
- DRG was prepared from adult C57BL/6 mice and incubated with 10 mM bupivacaine in vitro to induce apoptosis. (ovid.com)
- SiRNA-mediated TNF-α or TNF-R1 inhibition, but not TNF-R2 inhibition, rescued bupivacaine-induced DRG apoptosis. (ovid.com)
- In other cellular models, bupivacaine induces depolarization of the mitochondrial membrane potential, resulting in apoptosis. (lktlabs.com)
- Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. (lktlabs.com)
- Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. (lktlabs.com)
Contains bupivacaine2
- Each vial contains bupivacaine at a nominal concentration of 13.3 mg/mL. (rxlist.com)
- The novel delivery system contains bupivacaine within a carrier molecule that allows gradual release over an extended period. (healio.com)
Double-blind randomized study1
- We conducted a prospective double-blind randomized study assessing bupivacaine end-of-surgery wound infiltration for pain relief in thyroid surgery. (springer.com)
Patients16
- patients treated with femoral nerve block used twice as much as those treated with bupivacaine. (medscape.com)
- However, elderly patients are more likely to have low blood pressure or kidney problems, which may require caution and an adjustment in the dose for patients receiving bupivacaine injection. (mayoclinic.org)
- We included 53 patients in this study whom were randomly divided into two groups, namely Group B and Group C. In Group B (25 patients), each patient received 3 mL of bupivacaine and left 5 min sitting up, whereas in Group C (28 patients), each patient received 2.5 mL of bupivacaine and was asked to lie supine immediately. (nih.gov)
- High blood levels of bupivacaine must be avoided in patients with hepatic impairment. (who.int)
- The objective of this study was to compare the block durations and haemodynamic effects associated with intrathecal levobupivacaine or bupivacaine in elderly patients undergoing transurethral prostate surgery. (biomedsearch.com)
- Participated in this study 47 patients being 24 in the levobupivacaine group and 23 in the bupivacaine group. (scielo.br)
- Using liposomal bupivacaine to control pain in patients after gynecological surgery reduced the amount of narcotics needed and may lead to faster recovery times, a recent study found. (obgyn.net)
- During the first day following surgery, 21.5% of the patients treated with liposomal bupivacaine required opioids, while 46.9% of patients who received bupivacaine HCI were given opioids to control pain. (obgyn.net)
- By day two, just 7.4% of patients treated with liposomal bupivacaine were given opioids compared with 27.2% in the other group. (obgyn.net)
- RESULTS: Sixty-seven liposomal bupivacaine and 262 elastomeric bupivacaine pump patients were included. (ivteam.com)
- Conclusion When added to an aggressive ERP, liposomal bupivacaine does not decrease the amount of total opioid consumption, the incidence of AEs or the LOS in patients undergoing MIS sigmoid resection. (bmj.com)
- Among patients undergoing shoulder arthroplasty, liposomal bupivacaine was shown to provide better pain relief at 19 to 21 weeks post-surgery with fewer complications compared with continuous interscalene nerve block, according to research published in the Journal of Shoulder & Elbow Surgery . (clinicalpainadvisor.com)
- In this prospective clinical trial, 70 patients undergoing shoulder arthroplasty were randomly assigned to receive continuous interscalene nerve block (n=36) or liposomal bupivacaine (n=34) with a single bolus interscalene block. (clinicalpainadvisor.com)
- We performed real-time ultrasound guidance for infraorbital nerve blocks in TN patients using a high concentration of tetracaine dissolved in bupivacaine. (deepdyve.com)
- All patients could not continue drug therapy with carbamazepine due to side effects and they received an ultrasound-guided infraorbital nerve block with a high concentration of tetracaine dissolved in bupivacaine.MethodsThe patient was placed in the supine position and the patient's face was sterilized and draped. (deepdyve.com)
- However, elderly patients are more likely to have kidney or liver problems, which may require caution for patients receiving bupivacaine liposome injection. (findatopdoc.com)
Surgery7
- Since bupivacaine is given as needed before a surgery or dental procedure, you are not likely to be on a dosing schedule. (cigna.com)
- Gozal Y, Shapira SC, Gozal D, Magora F (1994) Bupivacaine wound infiltration in thyroid surgery reduces postoperative pain and opioid demand. (springer.com)
- There is currently a lack of evidence around the use of liposomal bupivacaine as a nerve block to treat pain after surgery. (cochrane.org)
- Further large studies are required to see if there is a role for liposomal bupivacaine to treat pain after surgery. (cochrane.org)
- This review assessed how good liposomal bupivacaine sensory nerve blocks are at treating pain after surgery, and whether there are any risks associated with their use. (cochrane.org)
- Overall, the lack of evidence, due to the small number of trials each reporting different outcomes, prevented a full assessment of the role of liposomal bupivacaine administered as a nerve block for the management of pain after surgery in adults. (cochrane.org)
- As such, further research is required to evaluate the role of liposomal bupivacaine as a nerve block to treat pain after surgery. (cochrane.org)