Virus diseases caused by the BUNYAVIRIDAE.
A family of viruses, mainly arboviruses, consisting of a single strand of RNA. Virions are enveloped particles 90-120 nm diameter. The complete family contains over 300 members arranged in five genera: ORTHOBUNYAVIRUS; HANTAVIRUS; NAIROVIRUS; PHLEBOVIRUS; and TOSPOVIRUS.
A genus of the family BUNYAVIRIDAE comprising many viruses, most of which are transmitted by Phlebotomus flies and cause PHLEBOTOMUS FEVER. The type species is RIFT VALLEY FEVER VIRUS.
A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE. A large number of serotypes or strains exist in many parts of the world. They are transmitted by mosquitoes and infect humans in some areas.
A genus of the family BUNYAVIRIDAE containing over 150 viruses, most of which are transmitted by mosquitoes or flies. They are arranged in groups defined by serological criteria, each now named for the original reference species (previously called serogroups). Many species have multiple serotypes or strains.
A species in the genus PHLEBOVIRUS of the family BUNYAVIRIDAE, infecting vertebrates and vectored by ticks. It has not been associated with human disease though antibodies have been isolated from human sera.
A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.
A serotype of the species California encephalitis virus (ENCEPHALITIS VIRUS, CALIFORNIA), in the genus ORTHOBUNYAVIRUS, causing human MENINGOENCEPHALITIS. This is the agent most responsible for California encephalitis (ENCEPHALITIS, CALIFORNIA), the most prevalent mosquito-borne disease recognized in the United States.
A genus of the family BUNYAVIRIDAE named after NAIROBI SHEEP DISEASE, an acute, hemorrhagic, tick-borne, gastroenteritis affecting sheep and goats. The type species is Dugbe virus. Some viruses in this genus are capable of causing severe and fatal disease in humans.
A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found primarily in rodents and humans. Transmission does not appear to involve arthropods. HANTAAN VIRUS is the type species.
A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE. Serotypes are found in temperate and arctic regions and each is closely associated with a single species of vector mosquito. The vertebrate hosts are usually small mammals but several serotypes infect humans.
The type species of the genus HANTAVIRUS infecting the rodent Apodemus agrarius and humans who come in contact with it. It causes syndromes of hemorrhagic fever associated with vascular and especially renal pathology.
A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.
Infections with viruses of the genus HANTAVIRUS. This is associated with at least four clinical syndromes: HEMORRHAGIC FEVER WITH RENAL SYNDROME caused by viruses of the Hantaan group; a milder form of HFRS caused by SEOUL VIRUS; nephropathia epidemica caused by PUUMALA VIRUS; and HANTAVIRUS PULMONARY SYNDROME caused by SIN NOMBRE VIRUS.
An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.
A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE family. Previously a large group of serotypes, most are now considered separate species.
A viral infection of the brain caused by serotypes of California encephalitis virus (ENCEPHALITIS VIRUS, CALIFORNIA) transmitted to humans by the mosquito AEDES triseriatus. The majority of cases are caused by the LA CROSSE VIRUS. This condition is endemic to the midwestern United States and primarily affects children between 5-10 years of age. Clinical manifestations include FEVER; VOMITING; HEADACHE; and abdominal pain followed by SEIZURES, altered mentation, and focal neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13)
A genus of plant viruses in the family BUNYAVIRIDAE. Tomato spotted wilt virus is the type species. Transmission occurs by at least nine species of thrips.
Influenza-like febrile viral disease caused by several members of the BUNYAVIRIDAE family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii.
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
A species in the genus PHLEBOVIRUS causing PHLEBOTOMUS FEVER, an influenza-like illness. Related serotypes include Toscana virus and Tehran virus.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
A species of HANTAVIRUS causing nephropathia epidemica, a mild form of HEMORRHAGIC FEVER WITH RENAL SYNDROME. It is found in most of Europe and especially in Finland, along with its carrier rodent, the bank vole (Clethrionomys glareolus).
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Viruses containing two or more pieces of nucleic acid (segmented genome) from different parents. Such viruses are produced in cells coinfected with different strains of a given virus.
Ribonucleic acid that makes up the genetic material of viruses.
A species of NAIROVIRUS, transmitted by the ixodid ticks and producing a lethal gastroenteritis in sheep and goats. Though a major veterinary pathogen, its effect on humans has not been firmly established.
A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
A family of hardbacked TICKS, in the subclass ACARI. Genera include DERMACENTOR and IXODES among others.
A species of HANTAVIRUS which emerged in the Four Corners area of the United States in 1993. It causes a serious, often fatal pulmonary illness (HANTAVIRUS PULMONARY SYNDROME) in humans. Transmission is by inhaling aerosolized rodent secretions that contain virus particles, carried especially by deer mice (PEROMYSCUS maniculatus) and pinyon mice (P. truei).
A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.
The relationships of groups of organisms as reflected by their genetic makeup.
An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Infections caused by arthropod-borne viruses, general or unspecified.
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus. The severe form is characterized by fever, HEMOLYTIC JAUNDICE, and renal damage.
Two or more vaccines in a single dosage form.
Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 7 and neuraminidase 3. It was first detected in turkeys in Britain in 1963 and there have been several outbreaks on poultry farms since that time. A couple cases of human infections have been reported.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.
Proteins prepared by recombinant DNA technology.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.

Seroepidemiology of California and Bunyamwera serogroup (Bunyaviridae) virus infections in native populations of Alaska. (1/168)

This study investigated the geographic distribution and prevalence of antibodies to California and Bunyamwera serogroup viruses in Native populations of Alaska, and demographic and ecologic risk factors associated with exposure. Sera (n = 1,635) from 18 communities were screened using an ELISA. All age groups were tested for antibodies to Jamestown Canyon (JC), Inkoo (INK), snowshoe hare (SSH), and Northway (NOR) viruses; persons > or = 45 years old (n = 90) from six communities were additionally tested for antibodies to Tahyna (TAH), Batai (BAT), Cache Valley (CV), and Sindbis (SIN) viruses. Thirty free-ranging mammals were tested by a plaque reduction neutralization test (PRNT) for antibodies to all eight viruses and to Getah (GET) virus. In Natives, overall antibody prevalence was 24.9% (JC = 17.6%, monotypic JC = 6.5%, INK = 11.1%, monotypic INK = 0.6%, SSH = 6.8%, monotypic SSH = 3.5%, and NOR = 6.2%). Five TAH, CV, and BAT virus exposures may be serologic cross-reactions, and no SIN virus antibodies were detected. Sindbis-like virus antibodies were found in 30% of the mammals. Most mammals had antibodies to NOR (83.3%) and California serogroup (70.0%) viruses; no GET virus exposures were found. Significant risk factors for human bunyavirus exposures were age group, ethnic-linguistic group, biotic province, climate zone, terrestrial vegetation, and presence of some ungulates and small mammals in communities. Sex was not a significant risk factor.  (+info)

Potential for evolution of California serogroup bunyaviruses by genome reassortment in Aedes albopictus. (2/168)

Aedes albopictus was introduced into the United States in used tires in 1985. Its successful colonization of the upper Midwest has potential to alter the current epidemiology of bunyaviruses that circulate in the region. It is permissive for the replication of several arboviruses, including La Crosse (LACV) and Jamestown Canyon (JCV) bunyaviruses. In this study, we demonstrate the ability of LACV and JCV to coinfect Ae. albopictus mosquitoes and to form all six possible reassortant genotypes. All reassortant viruses infect Ae. albopictus orally and can be transmitted to suckling mice. All reassortants are neurovirulent in mice. However, reassortant viruses carrying the LACV M segment in the foreign genetic background of JCV are more neuroinvasive than JCV, or any other reassortant genotype. In addition, these reassortants can replicate in gerbils and infect Ae. triseriatus, characteristics of LACV, but not JCV. Because Ae. albopictus is spreading into new geographic areas and feeds on a variety of mammals, including humans, it has the potential to transmit new, emerging bunyaviruses in nature.  (+info)

Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. (3/168)

Immunoglobulin M antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) is a rapid and versatile diagnostic method that readily permits the combination of multiple assays. Test consolidation is especially important for arthropod-borne viruses (arboviruses) which belong to at least three virus families: the Togaviridae, Flaviviridae, and Bunyaviridae. Using prototype viruses from each of these families and a panel of well-characterized human sera, we have evaluated and standardized a combined MAC-ELISA capable of identifying virus infections caused by members of each virus family. Furthermore, by grouping antigens geographically and utilizing known serological cross-reactivities, we have reduced the number of antigens necessary for testing, while maintaining adequate detection sensitivity. We have determined that a 1:400 serum dilution is most appropriate for screening antiviral antibody, using a positive-to-negative ratio of >/=2.0 as a positive cutoff value. With a blind-coded human serum panel, this combined MAC-ELISA was shown to have test sensitivity and specificity that correlated well with those of other serological techniques.  (+info)

Detection of anti-arboviral immunoglobulin G by using a monoclonal antibody-based capture enzyme-linked immunosorbent assay. (4/168)

Monoclonal antibody (MAb)-based capture enzyme-linked immunosorbent assays (ELISAs) for the detection of anti-arboviral immunoglobulin G (IgG ELISAs) were developed for a comprehensive array of medically important arboviruses from the Alphavirus, Flavivirus, and Bunyavirus genera. Tests were optimized and standardized so that maximum homology could be maintained among working parameters for the different viral agents, enabling a wide range of viruses to be easily tested for at one time. MAbs were screened for suitability as capture vehicles for antigens from the three genera. The final test configuration utilized group-reactive MAbs eastern equine encephalitis virus 1A4B-6, dengue 2 virus 4G2, and La Crosse encephalitis virus 10G5.4 to capture the specific inactivated viral antigens. Serum IgG was detected by using alkaline phosphatase-conjugated anti-human IgG (Fc portion). A dilution of 1:400 was chosen as the universal screening serum dilution, with endpoint titrations of serum samples testing positive eliminating occasional false-positive results. IgG ELISA results correlated with those of the standard plaque-reduction neutralization assays. As expected, some test cross-reactivity was encountered within the individual genera, and tests were interpreted within the context of these reactions. The tests were standardized for laboratory diagnosis of arboviral infections, with the intent that they be used in tandem with the corresponding IgM antibody-capture ELISAs.  (+info)

Effects of antigen-retrieval pretreatments for immunohistochemical detection of Akabane viral antigen. (5/168)

Effects of various antigen-retrieval pretreatment techniques for immunohistochemical detection of Akabane virus antigen were examined with formalin-fixed, paraffin-embedded tissues taken from mice intracerebrally inoculated with the virus. The results indicated that no pretreatment is necessary for the detection of the antigen, and excessive enzymatic pretreatment of sections may lead to false-negative results.  (+info)

Comparison of intertypic antigenicity of Aino virus isolates by dot immunobinding assay using neutralizing monoclonal antibodies. (6/168)

Neutralizing monoclonal antibodies (MAbs) against the Aino virus were prepared, and the neutralizing epitopes of the virus were defined by competitive binding assay. Seven continuous and overlapping neutralizing epitopes existed on the G1 glycoprotein of the Aino virus. Two antigenic domains were identified and were designated I and II, with domain II consisting of six epitopes. Dot immunobinding assays (DIAs) were performed with MAbs that recognized these seven neutralizing epitopes. DIAs were performed with 1 Australian strain and 21 isolates found in Japan between the years 1964 and 1995. The MAb response patterns of all isolates were divided into four groups. The Japanese isolates did not show large differences in antigenicity, but the antigenicity of the Australian strain collected in 1968 was significantly different from that of the Japanese strains; the Australian strain lacked reactivity to three epitopes and showed only low reactivity to one epitope.  (+info)

Reverse genetics system for Uukuniemi virus (Bunyaviridae): RNA polymerase I-catalyzed expression of chimeric viral RNAs. (7/168)

We describe here the development of a reverse genetics system for the phlebovirus Uukuniemi virus, a member of the Bunyaviridae family, by using RNA polymerase I (pol I)-mediated transcription. Complementary DNAs containing the coding sequence for either chloramphenicol acetyltransferase (CAT) or green fluorescent protein (GFP) (both in antisense orientation) were flanked by the 5'- and 3'-terminal untranslated regions of the Uukuniemi virus sense or complementary RNA derived from the medium-sized (M) RNA segment. This chimeric cDNA (pol I expression cassette) was cloned between the murine pol I promoter and terminator and the plasmid transfected into BHK-21 cells. When such cells were either superinfected with Uukuniemi virus or cotransfected with expression plasmids encoding the L (RNA polymerase), N (nucleoprotein), and NSs (nonstructural protein) viral proteins, strong CAT activity or GFP expression was observed. CAT activity was consistently stronger in cells expressing L plus N than following superinfection. No activity was seen without superinfection, nor was activity detected when either the L or N expression plasmid was omitted. Omitting NSs expression had no effect on CAT activity or GFP expression, indicating that this protein is not needed for viral RNA replication or transcription. CAT activity could be serially passaged to fresh cultures by transferring medium from CAT-expressing cells, indicating that recombinant virus containing the reporter construct had been produced. In summary, we demonstrate that the RNA pol I system, originally developed for influenza virus, which replicates in the nucleus, has strong potential for the development of an efficient reverse genetics system also for Bunyaviridae members, which replicate in the cytoplasm.  (+info)

Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. (8/168)

Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames. We have generated a mutant virus lacking NSs, called BUNdelNSs, by reverse genetics. Compared with the wild-type (wt) virus, BUNdelNSs exhibited a smaller plaque size and generated titers of virus approximately 1 log lower. In mammalian cells, the mutant expressed greatly increased levels of N protein; significantly, the marked inhibition of host cell protein synthesis shown by wt virus was considerably impaired by BUNdelNSs. When inoculated by the intracerebral route BUNdelNSs killed BALB/c mice with a slower time course than wt and exhibited a reduced cell-to-cell spread, and titers of virus in the brain were lower. In addition, the abrogation of NSs expression changed Bunyamwera virus from a noninducer to an inducer of an interferon-beta promoter. These results suggest that, although not essential for growth in tissue culture or in mice, the bunyavirus NSs protein has several functions in the virus life cycle and contributes to viral pathogenesis.  (+info)

Cache Valley virus (CVV) is a member of the Bunyavirales order, Orthobunyavirus genus, and Bunyamwera serogroup, which was first isolated in 1956 from Culiseta inornata mosquitos collected in Utahs Cache Valley. CVV is an enveloped arbovirus, nominally 80-120 nm in diameter, whose genome is composed of three single-stranded, negative-sense RNA segments. The large segment of related bunyaviruses is approximately 6800 bases in length and encodes a probable viral polymerase. The middle CVV segment has a 4463-nucleotide sequence and the smallest segment encodes for the nucleocapsid, and a second non-structural protein. CVV has been known to cause outbreaks of spontaneous abortion and congenital malformations in ruminants such as sheep and cattle. CVV rarely infects humans, but when they are infected it has caused encephalitis and multiorgan failure. The Cache Valley Virus genome is split into three parts. The three parts are called the small, medium, and large segments, based on the number of ...
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The Shasta Mosquito and Vector Control District is proud to highlight the recent success of our Open House & Centennial Celebration. This event provided a unique opportunity for the public to tour the District facilities, see our programs first-hand, and find out how our programs have continued to protect public health in our community since 1919.. District tours departed from the office, home of our new 3D printer, and moved through to our newly remodeled library and lab. The library was outfitted with lifecycle displays, both graphic and tangible, featuring not just mosquitoes, but other animals too. On the table were four Dino-Lite digital microscope stations featuring phases of the mosquito lifecycle as well as water fleas, a water leach, butterflies and more for an up-close exploration. Here, we also discussed some of our research and development projects, including overwintering mosquito surveillance, cache valley virus surveillance, and bioassay and cage trial efforts for product quality ...
Also my favorite parts about Tuesdays? Number one, I have practice which has never failed to make me ridiculously happy. Number two, Taco Tuesday at Del Taco baby. Me and one of my team mates named Mack (Makota) have started this tradition of after practice on tuesdays hitting up the Del Taco right next to Open Court. Brilliant plan. 3 tacos for a buck? Have you ever heard a better deal than that one? Probably not, cause Im pretty positive there isnt one out there. Not the best tacos in the world, in fact I definitely prefer Taco Bell tacos... but none the less quantity over quality just wins me over on this one ...
Hard-boil eggs. (Place eggs in a single layer in a sauce pan and cover them by at least 1 inch with cold water. Heat until just boiling and remove from burner. Remove from stove and cover. Let eggs stand in hot water for 12-15 minutes. By cooking your eggs in hot water, not boiling, you will avoid the ugly, but harmless, green ring that forms around yolks ...
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Filter caches and way-predictors are common approaches to improve the efficiency and/or performance of first-level caches. Filter caches use a small L0 to provide more efficient and faster access to a small subset of the data, and work well for programs with high locality. Way-predictors improve efficiency by accessing only the way predicted, which alleviates the need to read all ways in parallel without increasing latency, but hurts performance due to mispredictions.In this work we examine how SRAM layout constraints (h-trees and data mapping inside the cache) affect way-predictors and filter caches. We show that accessing the smaller L0 array can be significantly more energy efficient than attempting to read fewer ways from a larger L1 cache; and that the main source of energy inefficiency in filter caches comes from L0 and L1 misses. We propose a filter cache optimization that shares the tag array between the L0 and the L1, which incurs the overhead of reading the larger tag array on every ...
edited Sorry for not posting on this issue, even thought I have been assigned and everything So the basic idea that I have been working on is to make a key/value cache to speed up random reads. Test setup: Used the same test parameters that are used in the BT paper so it would be easy to compare and test have currently only been done on a single machine cluster with one HRegionServer. That setup includes 1column/family and every value is 1000B. Some numbers for testing this extremely simple cache are: Tests done over 10000 reads Random reads without cache: 481 r/s 481 KB/s Random reads with cache: 4019 r/s 4019 KB/s Some other test to compare the difference when using multiple columns/family turned out to give the following numbers: 5 columns/family everything else the same as above. Random reads without cache: 445 r/s 2223 KB/s Random reads with cache: 3588 r/s 17940 KB/s 10 columns/family everything else the same as above. Random reads without cache: 24 r/s 240 KB/s Random reads with cache: 25 ...
Were taking added precautions to keep our clients and employees safe during the COVID-19 outbreak. We also recognize that now more than ever, clients
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Holds research indicates that the compromised data was the work of a single Russian hacking organization and that it is currently in possession of the worlds largest cache of stolen data.
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Took 0.23 seconds and 1.75MB of RAM; Used 73 files and 32 queries; Sent 5 events; 0 cache hits and 0 misses; Shimmie version trunk ...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease. Haemophysalis longicornis ticks have been considered the vector of severe fever with thrombocytopenia syndrome virus (SFTSV). However, clear data on the transmission of SFTS from ticks to humans are limited. We report an 84-year-old woman who presented with fever and altered mentality, which was confirmed as SFTS with encephalopathy by reverse-transcription polymerase chain reaction in blood and cerebrospinal fluid. The SFTSV was also identified in the tick that bit her, H. longicornis. Phylogenetic analyses indicated that the SFTSV from the patient and the tick was identical. The patient gradually recovered with treatments of corticosteroids and immunoglobulin. These findings provide further evidence of SFTS viral transmission from H. longicornis to human.
1. JonesKE, PatelNG, LevyMA, StoreygardA, BalkD, et al. (2008) Global trends in emerging infectious diseases. Nature 451: 990-993.. 2. KupferschmidtK (2012) Infectious disease. Scientists rush to find clues on new animal virus. Science 335: 1028-1029.. 3. HoffmannB, ScheuchM, HoperD, JungblutR, HolstegM, et al. (2012) Novel orthobunyavirus in Cattle, Europe, 2011. Emerg Infect Dis 18: 469-472.. 4. GariglianyMM, BayrouC, KleijnenD, CassartD, JollyS, et al. (2012) Schmallenberg virus: a new Shamonda/Sathuperi-like virus on the rise in Europe. Antiviral Res 95: 82-87.. 5. BeerM, ConrathsFJ, WHVDP (2012) Schmallenberg virus - a novel orthobunyavirus emerging in Europe. Epidemiol Infect 1-8.. 6. OIE (2012) Schmallenberg virus. OIE technical factsheet on SBV. May 2012.. 7. GariglianyMM, BayrouC, KleijnenD, CassartD, DesmechtD (2012) Schmallenberg virus in domestic cattle, Belgium, 2012. Emerg Infect Dis 18: 1512-1514.. 8. ElbersAR, LoeffenWL, QuakS, de Boer-LuijtzeE, van der SpekAN, et al. (2012) ...
Abstract. Severe fever with thrombocytopenia syndrome (SFTS), which is caused by a novel bunyavirus, is an emerging infectious disease in China. In 2011, this new virus was designated as severe fever with thrombocytopenia syndrome virus (SFTSV). The aim of the present study was to determine the seroprevalence and risk factors of SFTSV infection. The investigation was conducted among the general population in Jiangsu Province, China in 2011. A total of 2,510 serum samples were collected. Testing by enzyme-linked immunosorbent assay was conducted to determine the seroprevalence of SFTSV infection. Result showed that the overall seroprevalence of SFTSV infection was 0.44% (11 of 2,510) in seven counties in Jiangsu Province. Multiple variable logistic regression analysis showed that raising goats, farming, and grazing were risk factors for SFTSV infection. Raising goats, farming, and grazing might be important risk factors for virus exposure, and appropriate health education could be useful in preventing
Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the most dangerous pathogens by the World Health Organization, has 12-30% fatality rates with a characteristic thrombocytopenia syndrome. With a majority of clinically diagnosed SFTSV patients older than ~50 years of age, age is a critical risk factor for SFTSV morbidity and mortality. Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fully recapitulates the clinical manifestations of human infections. Whereas young adult ferrets (≤2 years of age) did not show any clinical symptoms and mortality, SFTSV-infected aged ferrets (≥4 years of age) demonstrated severe thrombocytopenia, reduced white blood cell counts and high fever with 93% mortality rate. Moreover, a significantly higher viral load was observed in aged ferrets. Transcriptome analysis of SFTSV-infected young ferrets revealed strong interferon-mediated anti-viral signalling, whereas inflammatory immune responses were markedly
PubMedID: 26322483 | Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome (SFTS)-causing novel bunyavirus. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology | 10/1/2015
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease recently discovered in northeast and central China. SFTS cause high fatality rate of 12% and as high as 30% in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia (low platelet count), leucopenia (low white blood cell count), and elevated liver enzyme level.SFTS occurs in rural areas from March to November, and a majority of cases are from April to July. In 2009 Xue-jie Yu and colleagues isolated the SFTS virus (SFTSV) from SFTS patients blood. SFTSV is a Phlebovirus in the family of Bunyaviridae. The life cycle of the SFTSV most likely involves arthropod vectors and animal hosts. Humans are accidental hosts and play no role in the life cycle of the SFTSV. SFTSV has been detected from Haemaphysalis longicornis ticks. The transmission routine of SFTSV is unknown, but person-to-person transmission either plays no role or at least is not an ...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel phlebovirus SFTS virus (SFTSV). The major clinical signs and symptoms are fever, nausea, anorexia, thrombocytopenia, leukopenia, lymphadenopathy and hemorrhagic tendency. SFTS was first reported in China, followed by South Korea and Japan. In South Korea, the first patient was reported in 2012 and 35 persons were diagnosed with SFTS in 2013. We conducted a sero-surveillance study of SFTSV of healthy people on Mui Island.. Methods: Mui Island, located in Incheon, western South Korea (126.3876-126.4472E, 37.3648-37.4128N), has an area of 10.27 km2 and a population of 835 registered persons. The majority of residents are engaged in both agriculture and coastal fishery. Blood samples were collected during November 2014 from 203 healthy volunteers (female 127, male 76, 30 to 97 years old, median 67). The IgG and IgM antibody against SFTSV was detected using indirect ...
The British farming industry is in its second year of the ongoing Schmallenberg virus (SBV) infection (Davies and others 2012). Work from continental EU shows the degree of herd/flock seropositivity (and possible immunity) can vary geographically (Garigliany and others 2012, Bayrou and others 2013, Beer and others 2013), presumably due to differences in vector exposure factors. The UK industry remains unsure of the extent of exposure within the national flock, since national surveillance to date has focused on the geographic spread of infection rather than the degree of exposure at flock level (AHVLA 2013). This work investigated the extent of virus exposure and, therefore, possible immunity (as determined by seropositivity to SBV) in flocks where SBV infection was confirmed or likely (due to close proximity to confirmed infection), to give farmers an indication of flock susceptibility, to aid their management decision making.. Client farms wanting to understand their flock SBV exposure and, ...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne banyangvirus and is associated with high fatality. Despite increasing incidence of SFTS and serious public health concerns in East Asia, the pathogenesis of lethal SFTS virus (SFTSV) infection in humans is not fully understood. Numbers of postmortem examinations to determine target cells of the viral infection have so far been limited. Here we showed that B cells differentiating into plasmablasts and macrophages in secondary lymphoid organs were targets for SFTSV at the end stage of lethal infection, and the majority of SFTSV-infected cells were B cell-lineage lymphocytes. In affected individuals, B cell-lineage lymphocytes with SFTSV infection were widely distributed in both lymphoid and nonlymphoid organs, and infiltration of these cells into the capillaries of the organs could be observed occasionally. Moreover, a human plasmablastic lymphoma cell line, PBL-1, was susceptible to SFTSV ...
PubMedID: 26564632 | [Epidemiological analysis on severe fever with thrombocytopenia syndrome under the national surveillance data from 2011 to 2014, China]. | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | 6/1/2015
A Case of Severe Fever With Thrombocytopenia Syndrome Accompanied by Self-Limiting Severe Proteinuria That Inversely Correlated With the Platelet Count
T-705 inhibited SFTSV replication in vitro and showed therapeutic efficacy in vivo. T-705 has been shown to possess favorable antiviral activities against various RNA viruses and has a therapeutic effect on these viral infections in animal models (16, 31). T-705 was identified as a potential drug for the treatment of influenza virus infection. Regarding the mechanism of action of T-705, it has been reported that T-705 is converted to its phosphoribosylated metabolites (T-705RMP and T-705RTP) by host cellular kinases and that T-705RTP inhibits the activity of the RNA-dependent RNA polymerase of a number of viruses (33). Recently, T-705 has been licensed for use by the Ministry of Health, Labour and Welfare of Japan. However, its use has been limited to the events of the outbreak due to novel or reemerging influenza viral infections. T-705 was also considered as a potential therapeutic agent against Ebola virus disease (EVD) during the 2014-2015 EVD outbreak throughout West Africa ...
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We analyzed the whole-genome sequence of African swine fever virus Belgium 2018/1. The strain fits into the European genotype II (>99.98% identity). The high-coverage sequence revealed 15 differences compared with an improved African swine fever viru ...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is tick-borne viral disease that was first suspected in China in 2009. The causative virus (SFTSV) was isolated in 2009 and reported in 2011, and SFTSV expanded its geographic distribution in 2012-2013, from China to South Korea and Japan. Most SFTSV infections occur through Haemaphysalis longicornis. However, SFTSV infection can also occur between family members, and nosocomial transmission of SFTSV is also possible through close contact with a patient. In this study, we first analyzed clinical, epidemiological, and laboratory data for SFTS patients and family members of an index patient in Korea. The S segment of SFTSV was amplified from the sera of three patients, and the S segment of SFTSV and IgG specific to SFTSV were detected in the serum from one family member; although this individual had no history of exposure to H. longicornis, she frequently had close contact with the index patient. In Korea, SFTSV infection among family members
Even though the largest part of livestock in the Netherlands has become immune to Schmallenberg virus (SBV), the virus is still circulating. A recent study by Central Veterinary Institute (CVI), part of Wageningen UR, shows a large decrease of the percentage of SBV infected Culicoides biting Midges in the Netherlands.
Risks for Akabane disease, Akabane disease treatments, recommended products for Akabane disease, ways to prevent Akabane disease, causes of Akabane disease
TY - JOUR. T1 - 18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model. AU - Hayasaka, Daisuke. AU - Nishi, Kodai. AU - Fuchigami, Takeshi. AU - Shiogama, Kazuya. AU - Onouchi, Takanori. AU - Shimada, Satoshi. AU - Tsutsumi, Yutaka. AU - Morita, Kouichi. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that causes fever, enteritis, thrombocytopenia, and leucopenia and can be fatal in up to 30% of cases. However, the mechanism of severe disease is not fully understood. Molecular imaging approaches, such as positron-emission tomography (PET), are functional in vivo imaging techniques that provide real-time dynamics of disease progression, assessments of pharmacokinetics, and diagnoses for disease progression. Molecular imaging also potentially provides useful approaches to explore the pathogenesis of viral infections. Thus, the purpose of this study was to image the pathological ...
Since August 2011, both the Netherlands and Germany have reported outbreaks of a disease in cattle, with clinical signs including fever, reduced milk yield, inappetence, loss of body condition and, principally in Dutch herds, diarrhoea. Herds experienced outbreaks of disease lasting 2-3 weeks, with individual affected animals recovering over several days. More recently (November 2011 onwards) there have been reports of miscarriages and stillbirths associated with congenital (present at birth) abnormalities affecting mainly sheep but also cattle and goats. Tests carried out on cases in Germany and the Netherlands have identified a novel virus that has tentatively been named Schmallenberg virus (SBV). This virus appears to belong to a group of viruses that are spread by insect vectors, principally midges and mosquitoes, although a vector that may be responsible for transmission of SBV has not been identified yet ...
Reemergence of Schmallenberg virus (SBV) occurred among lambs (n = 50) in a sheep flock in Belgium between mid-July and mid-October 2012. Bimonthly assessment by quantitative reverse transcription PCR and seroneutralization demonstrated that 100% of
The Centers for Disease Control and Prevention (CDC) in collaboration with health officials in Missouri and Tennessee have identified six new cases of people sick with Heartland virus: five in Missouri and one in Tennessee. The new cases, discovered in 2012 and 2013, are in addition to two discovered in 2009 and are described today in CDCs Morbidity and Mortality Weekly Report.. Heartland virus was first reported in two northwestern Missouri farmers who were hospitalized in 2009 with what was thought to be ehrlichiosis, a tick-borne disease. However, the patients failed to improve with treatment and testing failed to confirm ehlrlichiosis. Working with state and local partners, CDC eventually identified the cause of the mens illness: a previously unknown virus in the phlebovirus family now dubbed Heartland virus.. Ongoing investigations have yielded six more cases of Heartland virus disease, bringing to eight the total number of known cases. All of the case-patients were white men over the age ...
Free Online Library: Novel orthobunyavirus in cattle, Europe, 2011.(DISPATCHES) by Emerging Infectious Diseases; Health, general Cattle Analysis Diarrhea Medical research Medicine, Experimental Veterinary supplies industry
Definition of orthobunyavirus in the Definitions.net dictionary. Meaning of orthobunyavirus. What does orthobunyavirus mean? Information and translations of orthobunyavirus in the most comprehensive dictionary definitions resource on the web.
Senecavirus A, commonly known as Seneca Valley virus (SVV), is a picornavirus that has been infrequently associated with porcine idiopathic vesicular disease (PIVD). In late 2014 there were multiple PIVD outbreaks in several states in Brazil and samples from those cases tested positive for SVV. Beginning in July of 2015, multiple cases of PIVD were reported in the United States in which a genetically similar SVV was also detected. These events suggested SVV could induce vesicular disease, which was recently demonstrated with contemporary US isolates that produced mild disease in pigs. It was hypothesized that stressful conditions may exacerbate the expression of clinical disease and the following experiment was performed. Two groups of 9-week-old pigs were given an intranasal SVV challenge with one group receiving an immunosuppressive dose of dexamethasone prior to challenge. After challenge animals were observed for the development of clinical signs and serum and swabs were collected to study viral
We have reported the case of a severely ill patient with SFTSV-associated encephalitis/encephalopathy in whom an SCC lesion was detected, but showed spontaneous resolution. The presence of a reversible SCC lesion has been reported in patients with a broad spectrum of diseases and conditions, and is referred to as RESLES [3]. Infection is the most common cause of this abnormality. To the best of our knowledge, this is the first reported case of RESLES in a patient with SFTSV infection.. The common neurological symptoms of RESLES associated with encephalitis/encephalopathy may include delirium, short-term disturbance of consciousness, and seizures, but usually patients show complete recovery without neurological sequelae after a short disease course [13, 14]. Although CNS manifestations are common in patients with SFTS, signs of severe CNS disturbance, such as coma and convulsion, are thought to be major clinical indicators of poor prognosis [2]. An epidemiologic study of 538 patients with SFTS ...
An Oropouche virus strain was isolated from a novel host (Callithrix sp.) in Arinos, Minas Gerais State, southeastern Brazil. The virus was identified by complement fixation test and confirmed by reverse transcription-polymerase chain reaction. Phylogenetic analysis identified this strain as a genotype III isolate previously recognized only in Panama.
Find Out How Many Calories Are In Cache Valley Double Twist Cheese Stick, Good or Bad Points and Other Nutrition Facts about it. Take a look at Cache Valley Double Twist Cheese Stick related products and other millions of foods.
From BioPortfolio: Due to the Zika epidemic, which began in 2015, and the outbreak of yellow fever early in 2017, Brazil runs a serious risk of being afflicted by Oropouche, anoth...
Strange Bedfellows: How a Science Museum, a State Agency, and Local Organizers Made It Possible to Re-Write Rochester, New Yorks History. Eduardo A. Ortiz presented Cache Valley Utah Latino Voices and History, about the Latino Voice Project. The project began interviewing people in the Hispanic/Latino community of Cache Valley in 2007. In 2012 Ortiz reviewed those interviews and pointed out that the different experiences of newer and younger immigrants, people who came to U.S. young, and those who have immigrant parents need to be noted, so they interviewed seven Cache Valley high school students and conducted focus groups with his students at Utah State.. In the 1980s Cache Valley was 1.2% Spanish-language origin, with the population growing from 150 to 1600 people (2.4%) in the 20 years between 1970 and 1990, and then tripling by 2000 to 5700 (6.3%). This change was in part due to the 1986 Immigration Reform and Control Act as well as immigrants moving from gateway areas like New York, ...
The location was named Punta Rasca (Spanish for smooth or flat point and later corrupted to Punta Rassa) by the Spanish Conquistadors in the mid-16th century, who unloaded cattle in the area. Punta Rassa was a thriving cattle shipping town in the 1800s. Florida cattle would be loaded at the port onto ships destined for Cuba. It was one of the home bases for the King of the Cracker Cowboys Jake Summerlin, who by the time he was 40 was one of the wealthiest of the Florida cattle barons. The town of Punta Rassa was lined with wooden buildings, including a hotel and several bars, which were frequented by the many merchants and cattle sellers. Between 1835 and 1865, Punta Rassa was a site of many Indian skirmishes during the Seminole Indian Wars. As a result, Fort Dulany was built there in 1838, as an army supply depot. A hurricane destroyed Fort Dulany in October 1841, and the military was forced to look for a site less exposed to storms from the Gulf of Mexico. As a result of the search, ...
Orthobunyaviruses are enveloped viruses that can cause human and animal diseases. A novel and major member is the Schmallenberg virus(SBV), the etiological agent of an emerging disease of ruminants that has been spreading all over Europe since 2011. The glycoproteins Gn and Gc of orthobunyaviruses mediate the viral entry, and specifically Gc is a major target for the humoral immune response. For example, the N terminal subdomain of the SBV glycoprotein Gc is targeted by neutralizing monoclonal antibodies that recognize conformational epitopes. Here, we determined the structural features of the N terminus of Gc, and analysed its interaction with monoclonal antibodies. We were able to demonstrate that one of two N-glycosylation sites is essential for secretion and interaction with a subset of Gc-specific monoclonal antibodies. Furthermore, four disulfide bonds (S-S) were identified and the deletion of the third S-S blocked reactivity with another subset of mAbs with virus-neutralizing and ...
Read Natural M-segment reassortment in Potosi and Main Drain viruses: implications for the evolution of orthobunyaviruses, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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A new virus, first detected in 2011, that causes birth defects in sheep, cattle and goats, has got a toe-hold in Britain, but where did it come from?
Seneca Valley Virus sounds like the last bug youd want to catch, but it could be the next breakthrough cancer therapy. Now, scientists at the Okinawa Institute of Science and Technology (OI... Read more ...
For sale: Houses at Punta del Este, Properties, apartments and houses for rent and sale at Punta del Este La Barra José Ignacio Punta Ballena. Countrysides, investments, real state.
Gokuden Mutsuyo , Nishi Nobuyuki , Ootsubo Mitsuhiro , Fukushi Shuetsu , Saijo Masayuki , Nakadouzono Fumiko , Iwamoto Yuka , Yamamoto Mami , Hozumi Nodoka , Nakayama Kouichiro , Ishitani Kanji ,p,Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infection with a high mortality rate. It is caused by the SFTS virus (SFTSV) and is endemic in some areas in western Japan, … Japanese Journal of Infectious Diseases 71(3), 225-228, 2018 J-STAGE Ichushi Web ...
This hotel enjoys a tranquil location overlooking the Bad Fredeburg spa district in the town of Schmallenberg, close to beautiful countryside in the...
Akabane virus (AKAV), an arthropod-transmitted bunyavirus, is a major cause of congenital abnormalities and encephalomyelitis in ruminants. In 2010, there was a major outbreak of encephalomyelitis in Korea and fifteen AKAV strains, including AKAV-7, were isolated from cows. To identify the neuropathogenicity of AKAV-7, we performed experimental infection of cows. Six-month-old female Korean Holstein dairy cattle were inoculated with AKAV-7 by various routes, including intracerebral (IC), intrasubarachnoid space (IS), subcutaneous (SC) and intravenous (IV); a separate group was vaccinated before intravenous infection. Five of the six cows in the IC group and two of the six cows in the IS group showed clinical signs such as locomotor ataxia and paralysis of the hind limbs. Three of six cows died after IC infection 9-12 days post infection (dpi). Histopathologic changes such as nonsuppurative encephalomyelitis were confirmed in various parts of the central nervous system in the IC, IS and SC groups. Early
Disease X represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease, and so the R&D Blueprint explicitly seeks to enable cross-cutting R&D preparedness that is also relevant for an unknown Disease X as far as possible.. A number of additional diseases were discussed and considered for inclusion in the priority list, including: Arenaviral hemorrhagic fevers other than Lassa Fever; Chikungunya; highly pathogenic coronaviral diseases other than MERS and SARS; emergent non-polio enteroviruses (including EV71, D68); and Severe Fever with Thrombocytopenia Syndrome (SFTS).. These diseases pose major public health risks and further research and development is needed, including surveillance and diagnostics. They should be watched carefully and considered again at the next annual review. Efforts in the interim to understand and mitigate them are encouraged.. Although not included on the list of diseases to be considered at the ...
Tim writes: in twiv 221 Dickson was in his full form funny and breathing loudly into mic. Not sure whether to find endearing or irritating. : ) Dave writes: Thank you again for the TWiV mention! The models do work well and I am now in the process of assessing the success. Have a great week! Dave PS Lawrence University is in Appleton Wisconsin just south of Green Bay (home of the packers) Richard writes: Hi Vince and co-presenters, Enjoyed your last TWIV about newly emerging bunyaviruses. A couple of comments. Firstly, SFTSV (that really is a dreadful name, it goes against the tradition of naming bunyaviruses after their place of isolation, and severe fever and thrombocytopenia are hardly specific to this virus, think about all the arenaviruses causing haemorrhagic fever). I dont know whether this was picked up previously on TWIV but there was a report in NEJM about another phlebovirus, called Heartland virus, that caused two independent human infections associated with tick bites in Missouri. McMullan
The Schmallenberg virus causes lambs to be born dead or with serious deformities such as fused limbs and twisted necks, which mean they cannot survive.. Scientists are urgently trying to find out how the disease, which also affects cattle, spreads and how to fight it, as the number of farms affected increases by the day.. So far, 74 farms across southern and eastern England have been hit by the virus, which arrived in this country in January.. A thousand farms in Europe have reported cases since the first signs of the virus were seen in the German town of Schmallenberg last summer.. The National Farmers Union has called it a potential catastrophe and warned farmers to be vigilant. This is a ticking time bomb, said Alastair Mackintosh, of the NFU. We dont yet know the extent of the disease. We only find out the damage when sheep and cows give birth, and by then its too late.. It is unclear exactly how the disease arrived in Britain, but the leading theory is that midges carried the virus ...
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From the BBC Climate change is raising the risk of diseases such as Schmallenberg in the UK and northern Europe, say scientists. Schmallenberg virus affects
SCHMALLENBERG virus (SBV) had been confirmed on 83 farms in England by February 27. In an update, the AHVLA reported that five of the positive results had been confirmed from cattle premises and the remainder from sheep premises. It also noted that none of the affected farms had reported importing animals during 2011 from affected areas in mainland Europe.. In addition to counties already affected, cases had been identified in Berkshire and Gloucestershire, as well as on the Isle of Wight, all on sheep holdings.. Defras International Disease Monitoring (IDM) … ...
... this is a longer period of viremia than what is normally observed in cases of Bunyaviridae infections. The second human case of ... Infections by viruses of the families Bunyaviridae and Filoviridae. Scientific and Technical Review of the Office International ... there are no known symptoms of infection. There is a quick period of viraemia before seroconversion and the infection is ... However, if the animal is pregnant and not protected by antibodies from a previous infection, Cache Valley virus can be very ...
Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa ... After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to ... The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) ( ... The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, ...
The Oropouche virus (OROV) is found in the family Bunyaviridae. The study of apoptosis brought on by Bunyaviridae was initiated ... Viruses can remain intact from apoptosis in particular in the latter stages of infection. They can be exported in the apoptotic ... The progression of the human immunodeficiency virus infection into AIDS is due primarily to the depletion of CD4+ T-helper ... Cells may also die as direct consequences of viral infections. HIV-1 expression induces tubular cell G2/M arrest and apoptosis ...
During early infection, Andes virus can produce a weak, innate immune response in the cell. The entry and uncoating of the ... 15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International ... Although hantavirus infections are prevalent in the United States, there currently are very few recorded cases of HPS due to ... HCPS as a result of Andes orthohantavirus infection has a case fatality rate of about 25-35% in Argentina and 37% in Chile. ...
The tiboviruses that affect humans are limited to within 3 families: Flaviviridae, Reoviridae, and Bunyaviridae. Flaviviridae: ... For a person to acquire infection the tick must bite and feed for a sufficient period of time. ... Bunyaviridae: Virus: Crimean-Congo hemorrhagic fever virus Disease: Crimean-Congo hemorrhagic fever Vector: Hyalomma marginatum ...
Bunyaviridae family Hendra virus infection Hendra virus Hepatitis A Hepatitis A virus ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
Viralzone: Bunyaviridae ICTVdb Index of Viruses-Bunyaviridae The Big Picture Book of Viruses: Bunyaviridae Bunyaviridae Genomes ... Incidence of infection is closely linked to vector activity, for example, mosquito-borne viruses are more common in the summer ... Symptomatic infection typically causes non-specific flu-like symptoms with fever lasting for about three days. Because of their ... Bunyaviridae". ICTVdB-The Universal Virus Database, version 4. 2006. Retrieved 2009-01-01. Ballinger, MJ; Bruenn, JA; Hay, J; ...
They normally cause infection in rodents, but do not cause disease in them. Humans may become infected with hantaviruses ... Elliott RM (1990). "Molecular biology of the Bunyaviridae". The Journal of General Virology. 71 (3): 501-522. doi:10.1099/0022- ... Dobrava infections are similar, except that they often also have hemorrhagic complications. Puumala virus is carried by its ... Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X (2017). "Hantavirus infection: a global zoonotic challenge". Virol Sin. 32 (1): ...
... and remote infections (IgG), however PCR may also be used to identify early infections. There is no cure or vaccine for HPS. ... Family Bunyaviridae. In: Fauquet CM, editor; Mayo MA, editor; Maniloff J, editor; Desselberger U, et al., editors. Virus ... New and Evolving Infections of the 21st Century, New York: Springer-Verlag New York, Inc.; 2006. pp. 151-170. Nichol ST. Beaty ... Although ribavirin can be used to treat hantavirus infections, it is not recommended as a treatment for HPS due to unclear ...
"Human Infection with Bhanja Virus." Human Infection with Bhanja Virus. The American Journal of Tropical Medicine and Hygiene, n ... List of other related viruses which may be members of the family Bunyaviridae but have not been approved as species Mehlhorn, ... Due to viral infections not responding to antibiotics, treatment is mainly to reduce the signs and symptoms; for which ... "Bhanja Virus Infection in Hedgehogs and Bears (Viral Disease Link)". wildpro.twycrosszoo.org. Retrieved 2014-07-25.. ...
... in mosquito cells no cell death is observed and persistent infection is established. Whereas in mammalian cells infection is ... Batai virus is a member of the genus Orthobunyavirus and a member of the family Bunyaviridae. Batai virus is part of a diverse ... Infection results in high fever, chills, severe headache, dizziness, back, and abdominal pains. Other symptoms that have been ... Plyusnin, A. (2011). Bunyaviridae: Molecular and cellular biology. Norfolk, UK: Caister Academic Press. Liu, H.; Shao, X.; Hu, ...
Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases (Impact ... "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International Committee on Taxonomy ... Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases (Impact ...
As the infection progresses, the virus crosses the blood-brain barrier and spreads to the brain parenchyma leading to severe ... Oropouche fever is caused by the oropouche virus (OROV) that belongs to the bunyaviridae family of arboviruses. This virus is a ... Two of the patients already had underlying infections that can effect the CNS and immune system and in particular one of these ... It typically takes 4 to 8 days from the incubation period to first start noticing signs of infection, beginning from the bite ...
Schultze D, Korte W, Rafeiner P, Niedrig M (2012) First report of sandfly fever virus infection imported from Malta into ... Mertz GJ (1997) Bunyaviridae: Bunyaviruses, Phleboviruses, Nairoviruses and Hantaviruses. In: Clinical Virology, Richman DD, ... 2013) Characterization of the Salehabad virus species complex of the genus Phlebovirus (Bunyaviridae). J Gen Virol 94: 837-842 ... Sandfly fever Naples virus taxonomy Bunyaviridae Genomes-database search results from the Viral Bioinformatics Resource Center ...
Vesenjak-Hirjan J, Calisher CH, Beus I. Marton E. First natural clinical human Bhanja virus infection, p 297-301. 1980. In ... "ICTV 9th Report (2011) Bunyaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 31 January 2019. Phlebo ... Bunyaviridae) based on partial M segment sequence analyses". J. Gen. Virol. 84 (Pt 2): 465-73. doi:10.1099/vir.0.18765-0. PMID ... Bunyaviridae: Phlebovirus) from the Amazon region of Brazil". Am. J. Trop. Med. Hyg. 32 (5): 1164-71. doi:10.4269/ajtmh.1983.32 ...
In hantavirus induced hemorrhagic fever, incubation time is between two and four weeks in humans before symptoms of infection ... "ICTV 9th Report (2011) Bunyaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 31 January 2019. Hanta: ... "Hantavirus infection-haemorrhagic fever in the Balkans-potential nephrological hazards in the Kosovo war". Nephrology Dialysis ... "Neurological Disease That Is Fatal in Adult with Hantaan Virus Infection". J. Virol. 76 (17): 8890-8899. doi:10.1128/JVI.76.17. ...
Antibodies or virus have been detected in dogs, raccoons, cattle, and humans, but no evidence of infection has been found in ... Watts SL, Garcia-Maruniak A, Maruniak JE (2009). "Tensaw virus genome sequence and its relation to other Bunyaviridae". Virus ... Calisher CH, Lazuick JS, Lieb S, Monath TP, Castro KG (1988). "Human infections with Tensaw virus in south Florida: evidence ... but clinical disease from Tensaw virus infection in humans had not been reliably demonstrated as of 2006. Evidence that ...
15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International ... genetic identification of rodent host species and spillover infection". Virus Res. 168 (1-2): 88-96. doi:10.1016/j.virusres. ...
... the infection of a two-day-old white experimental mice with the virus results in deaths occurring 8-12 days after infection. ... Bunyaviridae, Flaviviridae). Tick-borne flaviviruses are among the most important viruses in the world, primarily Europe and ... have reported with severe disease such as encephalitis and other large outbreaks of fever illness connected infection with the ...
Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical ... Bunyaviridae Occurrences and deaths in North and South America. ...
Schmaljohn C.S. and Hooper, J.W. (2001). Bunyaviridae: The viruses and their replication. In: Fields Virology, 4' Edn, (D.M. ... It is transmitted to humans through mosquito bites and results in a brief benign generalised infection with headache, skin rash ... Bwamba fever presents itself as a severe, but benign generalised infection of short duration, usually only lasting four to five ... "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International Committee on Taxonomy ...
Most of Peters' current work in the laboratory deals with Bunyaviridae (including the phylogeny of phleboviruses such as Rift ... His arenavirus research concentrates on the effects of infection on cellular function, particularly those molecular ...
Bunyaviridae" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 29 January 2019. CS1 maint: discouraged ... becoming epizootic when denser populations of susceptible animals are exposed to infection."Nairobi sheep disease virus/Ganjam ...
In rodents, hantavirus produces a chronic infection with no adverse sequelae. In humans, hantavirus produces two major clinical ... 15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International ... CS1 maint: discouraged parameter (link) Peters CJ, Simpson GL, Levy H (1999). "Spectrum of hantavirus infection: hemorrhagic ... Bunyaviridae Occurrences and deaths in North and South America. ...
The overall risk of infection in humans is low. It was first isolated from a meadow vole found in Prospect Hill, Maryland for ... "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International Committee on Taxonomy ... Gibbs CJ Jr.Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA.Trans R Soc Trop Med Hyg ... Bunyaviridae Occurrences and deaths in North and South America. ...
Helicobacter pylori infection. Helicobacter pylori. Hemolytic-uremic syndrome (HUS). Escherichia coli O157:H7, O111 and O104:H4 ... Bunyaviridae family. Hepatitis A. Hepatitis A Virus. Hepatitis B. Hepatitis B Virus. ... Clostridium botulinum; Note: Botulism is not an infection by Clostridium botulinum but caused by the intake of botulinum toxin. ...
Although relatively low numbers of human infection with this virus have been reported, the virus is of public health interest ... Perrone, L. A.; Narayanan, K.; Worthy, M.; Peters, C. J. (2007). "The S Segment of Punta Toro Virus (Bunyaviridae, Phlebovirus ...
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... Segmented genomes: Bunyaviridae, Orthomyxoviridae, Arenaviridae, and Reoviridae (acronym BOAR). All are RNA viruses. Viruses ... "Bunyaviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Retrieved 2015-10-03. "Filoviridae". ViralZone. SIB Swiss ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ...
BAYV infection causes hantavirus pulmonary syndrome (HPS) and represents the second most common hantavirus in the United States ... 15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International ... Bunyaviridae: Hantavirus)". The American Journal of Tropical Medicine and Hygiene. 57 (4): 445-448. doi:10.4269/ajtmh.1997.57. ...
Picazo E, Giordanetto F (February 2015). "Small molecule inhibitors of ebola virus infection". Drug Discovery Today. 20 (2): ... "Development of FGI-106 as a broad-spectrum therapeutic with activity against members of the family Bunyaviridae". Virus ...
... is a vaccine that protects in humans against hantavirus infections causing Hantavirus hemorrhagic fever with ... The vaccine is considered important as acute hantavirus infections are responsible for significant morbidity and mortality ... Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae. *v. *t. *e. Artificial induction of immunity / Immunization ...
May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Bunyaviridae. *Rhabdoviridae (hundegalskab) [35]. *Orthomyxoviridae (influenza A, B og C). *Paramyxoviridae (Newcastle disease ... infection has an unexpected up side, at least in mice, since it protects them against bacterial infections..." ... Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Frontiers in Microbiology ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ... Smallpox infections have been eradicated.[196] Vaccines are available to prevent over thirteen viral infections of humans,[197] ... Hepatitis viruses can develop into a chronic viral infection that leads to liver cancer.[179][180] Infection by human T- ...
The Oropouche virus (OROV) is found in the family Bunyaviridae. The study of apoptosis brought on by Bunyaviridae was initiated ... Viral infection[edit]. Viral induction of apoptosis occurs when one or several cells of a living organism are infected with a ... The binding of nuclear receptors by glucocorticoids,[19] heat,[19] radiation,[19] nutrient deprivation,[19] viral infection,[19 ... The progression of the human immunodeficiency virus infection into AIDS is due primarily to the depletion of CD4+ T-helper ...
Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection (PDF) ... 本雅病毒科 Bunyaviridae. *正黏液病毒科 Orthomyxoviridae ... WHO: Novel coronavirus infection. 2013-02-11 [2013-02-13].. *^ James Gallagher. Coronavirus: Signs the new Sars-like virus can ... Camel infection 'led to Mers death'. BBC News. 2014-06-05 [2014-06-05].. ...
Infection Rate and B. grahamii in Ticks". Emerging Infectious Diseases. 18 (10): 1689-1690. doi:10.3201/eid1810.120390. PMC ... Organism: CCHF virus, a nairovirus, from the Bunyaviridae. *Vector: Hyalomma marginatum, Rhipicephalus bursa ... Tick-borne illnesses are caused by infection with a variety of pathogens, including rickettsia and other types of bacteria, ... For an individual to acquire infection, the feeding tick must also be infected. Not all ticks are infected. In most places in ...
It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... Examples in this class include the families Orthomyxoviridae, Paramyxoviridae, Bunyaviridae, Filoviridae, and Rhabdoviridae ( ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ...
15 June 2015). "Implementation of non-Latinized binomial species names in the family Bunyaviridae" (PDF). International ... the greater the likelihood of transmission and infection. The Dade County patient is thought to have contracted the previously ...
In adults, infection is asymptomatic, which means that the patient is a carrier of the infection, but experiences no symptoms ... California encephalitis orthobunyavirus belongs to the Bunyaviridae family of viruses. The La Crosse Virus from the same genus ... Initial infection by the virus and primary spread of the virus causes the onset of non-specific symptoms such as headache and ... It then can result in encephalitis, when inflammation of the brain, produced by infection by the virus, damages nerve cells, ...
As the infection progresses additional symptoms develop which include dark streaks on the main stem and wilting of the top ... "PP-212/PP134: Tospoviruses (Family Bunyaviridae, Genus Tospovirus)". Edis.ifas.ufl.edu. Retrieved 2014-06-15. Jones, D. R. 2005 ... Infection with these viruses results in spotting and wilting of the plant, reduced vegetative output, and eventually death. No ... Early symptoms of infection are difficult to diagnose. In young infected plants the characteristic symptoms consist of inward ...
... and thus rarely if ever causes secondary infections. A pulmonary anthrax infection starts with ordinary influenza-like symptoms ... Many viral agents have been studied and/or weaponized, including some of the Bunyaviridae (especially Rift Valley fever virus ... Barras V, Greub G (June 2014). "History of biological warfare and bioterrorism". Clinical Microbiology and Infection. 20 (6): ... Barras V, Greub G (June 2014). "History of biological warfare and bioterrorism". Clinical Microbiology and Infection. 20 (6): ...
It appears to be transmitted by midges (Culicoides spp.), which are likely to have been most active in causing the infection in ... Alexander., Plyusnin; M., Elliott, Richard (2011-01-01). Bunyaviridae : molecular and cellular biology. Caister Academic Press ... It is possible that the seasonality of the infection cycle would not entail a second epidemic circulation next year, due to the ... Kerstin Caroline Hahn: Organ and cell tropism and molecular characteristics of Schmallenberg virus infection in ruminants and ...
The infections could have occurred as early as 2003, based on the estimated ages of affected deer. Since the Lone Star tick ... Bunyaviridae: Phlebovirus) from Field Collected Arthropods". Am J Trop Med Hyg. 89 (3): 445-452. doi:10.4269/ajtmh.13-0209. PMC ... Most infections are diagnosed between May and September. People usually report having been bitten by a tick within two weeks ... Antibody titers against the virus may also be used to indicate infection with the Heartland virus. Treatment is non-specific. ...
Viral infection can often result in the death of the plant. The disease is mainly controlled by the elimination of the western ... of the Impatiens necrotic spot virus genome sequence and genetic comparison of the L proteins within the family Bunyaviridae. ... Symptoms of infection include a downward curling of the leaves, leaf tip dieback, stunting, necrosis of growing leaf tips, ... If virus remains a problem, other plants can be planted in that area that do not have the traits required for infection of INSV ...
Experimental infections of captive deer showed that they may serve as amplifying hosts for either virus. Deer infected with CVV ... Cross-infection experiments also were carried out to investigate the level of antibody cross-reactivity and cross-protection ... Bunyaviridae: Bunyamwera group) that appear to circulate in several regions of the United States, especially the Midwest. We ... immune to either CVV or POTV were cross-infected with the alternate virus and antibody responses following cross-infections ...
Find out information about Bunyaviridae infections. A family of enveloped spherical viruses whose lipid envelopes contain at ... least one virus-specific glycopeptide; members develop in the cytoplasm and mature... Explanation of Bunyaviridae infections ... Bunyaviridae. (redirected from Bunyaviridae infections). Also found in: Dictionary, Thesaurus, Medical. Bunyaviridae. [¦bən·yə′ ... Bunyaviridae infections , Article about Bunyaviridae infections by The Free Dictionary https://encyclopedia2.thefreedictionary. ...
Bunyaviridae / genetics * Bunyaviridae Infections / genetics * Bunyaviridae Infections / metabolism * Bunyaviridae Infections ... Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap- ...
... this is a longer period of viremia than what is normally observed in cases of Bunyaviridae infections. The second human case of ... Infections by viruses of the families Bunyaviridae and Filoviridae. Scientific and Technical Review of the Office International ... there are no known symptoms of infection. There is a quick period of viraemia before seroconversion and the infection is ... However, if the animal is pregnant and not protected by antibodies from a previous infection, Cache Valley virus can be very ...
Arbovirus Infections. Virus Diseases. Hepatitis, Viral, Animal. Bunyaviridae Infections. RNA Virus Infections. Hemorrhagic ... The secondary objective is to assess incidence of RVF infection in vaccinated personnel ...
Hantavirus (Bunyaviridae) infections in rodents from Orange and San Diego counties, California. S G Bennett, J P Webb Jr, M B ... These results indicated the putative site of infection and identified this rodent species as the source of infection. ... Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. G E Glass, W Livingstone, J N Mills, W G Hlady, J B ... Choclo Virus Infection in the Syrian Golden Hamster Eduardo J. Eyzaguirre, Mary Louise Milazzo, Frederick T. Koster and Charles ...
Bunyaviridae: infections and diagnosis. In: Kurstak E, Kurstak C, editors. Comparative diagnosis of viral diseases, Vol. IV. ... Virus infections of ruminants. Amsterdam: Elsevier Science Publishers; 1990. p. 467-480. ... all belonging to the family Bunyaviridae, genus Orthobunyavirus, and Simbu serogroup (1). Real-time PCR detected the genomic ... lesions probably caused by in utero infection with the new virus. ...
HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS ... ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS ... PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.. Meningitis, ...
... acute HIV infection is critical to understanding subtype-specific pathophysiologic differences, since u... ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ...
Bunyaviridae Infections / pathology * Bunyaviridae Infections / veterinary * Bunyaviridae Infections / virology* * Host- ...
CCHF is caused by infection with a tickborne virus of the Bunyaviridae family (1-3). Transmission occurs from the bite of an ... These findings will help direct future public health planning with the goal of reducing CCHF infection in the Georgia ... Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited. ...
Arbovirus Infections [C02.081]. *Phlebotomus Fever [C02.081.700]. *RNA Virus Infections [C02.782]. *Bunyaviridae Infections [ ... Influenza-like febrile viral disease caused by several members of the BUNYAVIRIDAE family and transmitted mostly by the ... family Bunyaviridae). J Gen Virol. 2014 Feb; 95(Pt 2):292-300. ...
Categories: Bunyaviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Association between movement and Sin Nombre virus (Bunyaviridae: Hantavirus) infection in North American deermice (Peromyscus ... during sexually transmitted infection and reproductive tract infection treatment among female sexually transmitted infection ... The role of co-infections in mother-to-child transmission of HIVexternal icon King CC, Ellington SR, Kourtis AP.. Curr HIV Res ... A trich-y question: should Trichomonas vaginalis infection be reportable?external icon. Hoots BE, Peterman TA, Torrone EA, ...
Rodent-borne hantaviruses (family Bunyaviridae) cause two distinct human infections; hemorrhagic fever with renal syndrome ( ... PUUV infection probability in bank voles was positively related to vole age. Infection probability was highest in the fire area ... The aim was to study the metabolic response during the early phase of acute infection. The qPCR panel developed in Paper I was ... For many infections transmitting to humans from reservoirs in nature, disease dispersal patterns over space and time are ...
Seroepidemiology of California and Bunyamwera serogroup (Bunyaviridae) virus infections in native populations of Alaska. Am J ... JCV infection is likely underdiagnosed due to lack of awareness of this virus and limited diagnostic testing options. The ... Specifically, infection with JCV should be included in the differential diagnosis of patients with mosquito exposure who ... It is important to be aware that infection with JCV may result in serologic cross-reactivity with other more common arboviruses ...
A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one ... Bunyaviridae. California encephalitis virus,. Enveloped. Helical. ss. Hantavirus. 11.. Rhabdoviridae. Rabies virus. Enveloped. ... for administration to a human or animal experiencing a viral infection or at risk of a viral infection. Such pharmaceutical ... The infection pathway and timing of RSV is well known, and is set forth in the lower right corner. As can be seen, at any time ...
encoded search term (Ebola Virus Infection) and Ebola Virus Infection What to Read Next on Medscape ... Ebola Virus Infection. Updated: Jan 14, 2021 * Author: John W King, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD ... Among infection survivors, only males had been shown to transmit the virus, via semen, in which the virus can persist for up to ... In fatal infections, the hosts tissues and blood contain large numbers of Ebola virions, and the tissues and body fluids are ...
26.2 Bunyaviridae family 478. 26.3 Climate Change and Bunyaviridae: Climatic influences on transmission cycles and subsequent ... Predictive modeling for emerging viral infections. Viral Infections and Global Change is an indispensable resource for research ... 14.3 Challenges in diagnosis of emerging viral infections 259. 14.4 Approaches to the diagnosis of emerging viral infections ... Part II Specific Infections 353. 19 New, Emerging, And Reemerging Respiratory Viruses 355. Fleur M. Moesker, Pieter L.A. Fraaij ...
A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found ... Bacterial Infections Chapter Cardiovascular Medicine Chapter Dermatology Chapter Emerging Infections Chapter Examination ... Infectious Disease - Emerging Infections Pages Antibiotic Resistance Antibiotic Resistant Salmonella Avian Influenza Carbapenem ... An infection caused by Hantaviruses. It manifests with flu-like symptoms but it rapidly progresses to life-threatening ...
A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found ... An infection caused by Hantaviruses. It manifests with flu-like symptoms but it rapidly progresses to life-threatening ... A genus of single-stranded, segmented, negative-sense RNA viruses in the family bunyaviridae. These viruses are transmitted by ... genus of the family Bunyaviridae causing diseases such as hemorrhagic fever, nephropathia epidemica, and Hantavirus Pulmonary ...
A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus- ... Bunyaviridae (e.g., Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV); and Flaviviridae, ... accounting for the disproportionate association of chronic HDV infection with terminal liver disease. Although HDV infection ... Upon infection by HBV, the incomplete partial double stranded DNA is repaired to form a 3.2-kb cccDNA, which serves as a ...
"It is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. "As soon as laboratory sampling ... The pathogenic virus, especially common in East and West Africa, is a member of the Bunyaviridae family of RNA viruses. ... affected is being treated in complete isolation in the Brownlee specialist unit in Glasgow and all the appropriate infection ...
Cache Valley and Potosi viruses (Bunyaviridae) in white-tailed deer (Odocoileus virginiamts): experimental infections and ... Life-threatening Cache Valley virus infection. N Engl J Med. 1997;336:547-9. (3.) Kuno G, Mitchell CJ, Chang G J, Smith GC. ... I. Virologic and serologic evidence of infection. Am J Trop Med Hyg. 1970;19:493-502. Grant L. Campbell,* James D. Mataczynski ... This isolate caused extensive cytopathic effects (CPE) in A549 (human lung adenocarcinoma) cells by 3 days after infection and ...
95-O. Tomato spotted wilt virus (Bunyaviridae, Tospovirus) infection alters feeding behavior of its vector Frankliniella ... AWARD 111-O. Assessment of Strawberry mild yellow edge virus infection in different ecotypes of the Chilean native strawberry ... 48-O. Changes in flavonoid biosynthetic pathway genes and anthocyanins due to virus infection in grapevine (Vitis vinifera L.) ... 124-O. Impact of zebra complex disease on the development of potato plants from seedborne infection of Candidatus Liberibacter ...
Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa ... After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to ... The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) ( ... The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, ...
Most of the diseases caused by viral infection are found to be fatal, and the diagnosis is difficult due to confusion with ... Zeller H, Bouloy M (2000) Infections by viruses of the families Bunyaviridae and Filoviridae. Rev Sci Tech 19:79-91PubMedGoogle ... Ji J, Du LQ, Xie QM, Cao YC, Zuo KJ, Xue CY, Ma JY, Chen F, Bee YZ (2009) Rapid diagnosis of duck plagues virus infection by ... Schmaljohn C (1996) Bunyaviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology, ...
Rift Valley Fever is an infection caused by the RVF virus belonging to the the Bunyaviridae family. It is a zoonosis - an ... The infection is endemic in northern, eastern, and southern Africa and outbreaks have also occurred in the Arabian Peninsula. ... Most patients recover 4 to 7 days later, but some end up with one or more severe forms of the infection: Ocular syndrome ( ... In some cases the infection is asymptomatic - persons do not exhibit symptoms. However, those who show symptoms get ill 2 to 6 ...
Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. ... If the infection is via tick bite, the incubation period is roughly one to three days, with a maximum of nine days, Dr. Radike ... I also dont know if we have any real indications that the infection has reached my country yet. I hope to find out more about ... I also dont know if we have any real indications that the infection has reached my country yet. I hope to find out more about ...
  • Characterization of the Sandfly fever Naples species complex and description of a new Karimabad species complex (genus Phlebovirus, family Bunyaviridae). (harvard.edu)
  • The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) (Hantaviridae), the Crimean-Congo hemorrhagic fever (CCHF) virus from the genus Orthonairovirus (Nairoviridae), Garissa virus and Ilesha virus from the genus Orthobunyavirus (Peribunyaviridae), and the Rift Valley fever (RVF) virus from the genus Phlebovirus (Phenuiviridae). (wikipedia.org)
  • Toscana virus (TOSV, Phlebovirus, family Bunyaviridae) infection is one of the most prevalent arboviruses in Spain. (cdc.gov)
  • Full Text Available The Bunyaviridae family is comprised of more than 350 viruses, of which many within the Hantavirus, Orthobunyavirus, Nairovirus, Tospovirus, and Phlebovirus genera are significant human or agricultural pathogens. (worldwidescience.org)
  • In this study we have compared the stabilities of three viruses within the Bunyaviridae family: the rodent-borne Hantavirus Hantaan virus (HTNV), the sand fly-borne Phlebovirus sandfly fever Sicilian virus (SFSV), and the tick-borne Nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV). (asm.org)
  • The Bunyaviridae family consists of five genera ( Orthobunyavirus , Hantavirus , Nairovirus , Phlebovirus , and Tospovirus ). (asm.org)
  • It is caused by a novel SFTS bunyavirus (SFTSV), in the genus of Phlebovirus , family Bunyaviridae [ 1 - 3 ]. (hindawi.com)
  • In this chapter the term ''bunyavirus'' refers to a member of the Bunyaviridae family, while the terms '' orthobunyavirus '' '' phlebovirus '' refer to viruses in the eponymous genus. (asmscience.org)
  • Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. (cdc.gov)
  • RVFV is a category A pathogen that belongs to the genus Phlebovirus, family Bunyaviridae. (nih.gov)
  • Os vírus brasileiros da família Bunyaviridae säo vírus RNA, isolados principalmente na Regiäo Amazônica, pertencentes aos gêneros Bunyavirus, Hantavirus e Phlebovirus. (bvsalud.org)
  • Infection is caused by RVF virus (family Bunyaviridae , genus Phlebovirus ), a zoonotic mosquitoborne virus. (blogspot.com)
  • In mosquito cells neither host cell transcription nor translation are inhibited, and although so far no function for the orthobunyavirus NSs protein has been found in mosquito cells, it seems the differential behavior of NSs could be one of the factors responsible for different outcomes of infection in mammalian and mosquito cell lines. (wikipedia.org)
  • The analysis detected nucleotide sequences homologous to arthropod-borne Akabane, Aino, and Shamonda viruses, all belonging to the family Bunyaviridae , genus Orthobunyavirus , and Simbu serogroup ( 1 ). (cdc.gov)
  • Cache Valley virus (CVV), a mosquitoborne member of the Bunyamwera serogroup, family Bunyaviridae, genus Orthobunyavirus, is geographically widespread in North America, where it circulates between mosquitoes and mammals (1). (thefreelibrary.com)
  • All those viruses are members of the Simbu serogroup, family Bunyaviridae , genus Orthobunyavirus , and known as arthropod-borne viruses that can cause illness in ruminants ( 9 ). (cdc.gov)
  • ventalloi Familia Bunyaviridae Genero Orthobunyavirus Virus Tete Hyalomma spp. (thefreedictionary.com)
  • SBV belongs to the genus Orthobunyavirus within the Bunyaviridae. (gla.ac.uk)
  • Akabane virus (AKAV), a member of the Orthobunyavirus genus in the family Bunyaviridae , is transmitted by an arthropod vector such as Culicoides biting midges. (beds.ac.uk)
  • The causative agent was identified as a virus in the family Bunyaviridae by electron microscopy. (wikipedia.org)
  • CCHF is caused by infection with a tickborne virus of the Bunyaviridae family ( 1-3 ). (cdc.gov)
  • Influenza-like febrile viral disease caused by several members of the BUNYAVIRIDAE family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii. (harvard.edu)
  • A genus of single-stranded, segmented, negative-sense RNA viruses in the family bunyaviridae. (fpnotebook.com)
  • A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. (fpnotebook.com)
  • aim of this paper therefore is to report in the Bunyaviridae family. (who.int)
  • By using primers targeted to a highly conserved 251-base portion of the smallest of the 3 RNA segments (RNA-S) of members of the Bunyamwera and California serogroups of the family Bunyaviridae, strain WI-03BS7669 was shown by PCR to share considerable homology with members of these serogroups (3). (thefreelibrary.com)
  • The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, especially Peribunyaviridae. (wikipedia.org)
  • Rift Valley Fever is an infection caused by the RVF virus belonging to the the Bunyaviridae family. (iamat.org)
  • family Bunyaviridae, genus Bunyavirus, species California encephalitis virus) is a leading cause of pediatric encephalitis in the United States, with ∼70 cases reported annually (C enters for D isease C ontrol and P revention 2003), and is distributed throughout the eastern United States ( C alisher 1983 ). (genetics.org)
  • The family Bunyaviridae is the largest family of animal viruses and includes many viruses that are known human pathogens. (asmscience.org)
  • Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus, a Nairovirus in the family Bunyaviridae. (wur.nl)
  • i.e., infected by a virus of the family Bunyaviridae 2 , which includes than 20 hantaviruses identified throughout the American continent 3 . (scielo.br)
  • Crimean-Congo hemorrhagic fever (CCHF) is a severe, often potentially fatal disease in humans, caused by infection with CCHF virus (CCHFV) belonging to the genus Nairovirus of the Bunyaviridae family. (thefreedictionary.com)
  • The Bunyaviridae family includes a growing number of viruses that have contributed to the burden of emerging and reemerging infectious diseases around the globe. (worldwidescience.org)
  • Full Text Available The Bunyaviridae is a family of arboviruses including both plant- and vertebrate-infecting representatives. (worldwidescience.org)
  • The Bunyaviridae is a large family comprising hundreds of viruses able to infect a broad range of vertebrate and invertebrate hosts. (gla.ac.uk)
  • Hantaviruses are enveloped negative-sense RNA viruses that belong to the family Bunyaviridae. (hindawi.com)
  • In conclusion, our study points out important differences in ex vivo stability among viruses within the Bunyaviridae family. (asm.org)
  • Members of the Bunyaviridae family are widely spread around the world and can cause severe and often even fatal zoonotic diseases. (asm.org)
  • The term hantavirus represents several groups of RNA-containing viruses (that are members of the virus family of Bunyaviridae ) that are carried by rodents and can cause severe respiratory infections termed hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). (medicinenet.com)
  • Hantaviruses constitute one of the 5 genera in the family Bunyaviridae and are associated with several natural host species including rodents, insectivores and bats. (centerwatch.com)
  • The full-genome sequences revealed that TFLV belonged to the genus Nairovirus, family Bunyaviridae. (springernature.com)
  • Electron microscopy revealed viruses consistent with members of the Bunyaviridae family. (cdc.gov)
  • Moreover, in cells expressing NSs protein from a cDNA plasmid, IFN- β transcripts were not inducible by poly(I : C). Unlike other members of the family Bunyaviridae , TOSV appears to express an NSs protein that is a weak antagonist of IFN induction. (microbiologyresearch.org)
  • This virus belongs to the family Bunyaviridae. (ebscohost.com)
  • Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonosis caused by Hantavirus (belonging to the Bunyaviridae family). (frontiersin.org)
  • Finally, a cDNA fragment of 3,737 bp was obtained, which showed homology to viral proteins, particularly to the RNA-dependent RNA polymerase of members of the family Bunyaviridae , but without high similarity to a known genus. (springer.com)
  • The isolate (XJ0625) was subsequently identified for the first time in China as TAHV belonging to the Bunyaviridae family by serological and molecular biology assays (Table 1 ). (biomedcentral.com)
  • Hantaviruses are single stranded RNA viruses in the family Bunyaviridae . (biomedcentral.com)
  • Bunyavirus , any virus belonging to the family Bunyaviridae. (britannica.com)
  • The virus that causes CCHF is contained within Nairovirus , a member of related pathogenic (disease-causing) viruses within the Bunyaviridae family. (encyclopedia.com)
  • It also provides up-to-date coverage of both the clinical aspects and basic science behind an array of specific emerging and reemerging infections, including everything from West Nile fever and Rift Valley fever to zoonotic hepatitis E and human bunyavirus. (wiley.com)
  • Viral Infections and Global Change is an indispensable resource for research scientists, epidemiologists, and medical and veterinary students working in ecology, environmental management, climatology, neurovirology, virology, and infectious disease. (wiley.com)
  • Viral infections of the leptomeninges and subarachnoid space. (bioportfolio.com)
  • Representing a major addition to the world literature on the subject, Viral Infections and Global Change explores trends of paramount concern globally, regarding the emergence and reemergence of vector-borne and zoonotic viruses. (wiley.com)
  • So, a highly efficient molecular-based advance detection technique, i.e., loop-mediated isothermal amplification (LAMP) method, is developed for diagnosis of viral infections by various workers. (springer.com)
  • Although common viral infections like the flu may cause a mild chest infection, some viruses can cause severe and even deadly chest infections. (healthhype.com)
  • The following animal models of viral infections have either been established or are under development at the BRL. (gmu.edu)
  • The protective roles of endosomal toll-like receptors (TLRs) and cytosolic nucleic acid sensors are well elucidated, but the pathogenic host factors during viral infections remain unclear. (frontiersin.org)
  • Although CLEC2 has been reported to interact with type I immunodeficiency virus (HIV-1), its role in viral infections is still unclear. (frontiersin.org)
  • These findings not only illustrate the immunomodulatory effects of EVs during platelet-leukocyte interactions, but also demonstrate the critical roles of CLEC2 and CLEC5A in acute viral infections. (frontiersin.org)
  • The common features of SARS-CoV and other acute viral infections are the early onset of inflammatory reactions with elevated local or systemic vascular permeability, before the adaptive immune system is fully activated. (frontiersin.org)
  • These observations suggest that innate immune responses contribute significantly to the pathogenesis of acute viral infections. (frontiersin.org)
  • These intracellular nucleic acid receptors/sensors have been defined as "protective host factors" as they are critical for host defense against viral infections. (frontiersin.org)
  • Therefore, we were interested to determine whether viruses activate membrane receptors on myeloid cells induce cytokine storms, and how these receptors contribute to complex cell-cell interactions during acute viral infections. (frontiersin.org)
  • In this review article, we illustrate the critical roles of C-type lectin receptors in innate immunity and discuss the potential of targeting these cell surface receptors in the treatment of acute viral infections. (frontiersin.org)
  • The common feature of acute viral infections is the rapid onset of inflammatory reactions after exposure to the virus. (frontiersin.org)
  • Monocytes/macrophages are thought to play an important role in pathogenesis of viral infections. (ebscohost.com)
  • Dr. Gowen specializes in pre-clinical development of antiviral therapies for the treatment of arenaviral and bunyaviral hemorrhagic fever agents, innate immunity to viral infections, modeling viral diseases, and virus-host cell interactions. (usu.edu)
  • Os arbovirus da familia Bunyaviridae de importancia veterinaria que causam enfermidades importantes em animais sao: NSDV que e um Nairovirus que ocorre em ovinos e caprinos e e transmitido por carrapatos, causa doenca grave e fatal e esta presente nas regioes central e leste da Africa e Oriente Medio (29). (thefreedictionary.com)
  • Although TFLV infections in humans and animals are currently unknown, our findings may provide clues to understand the potential infectivity and to develop of pre-emptive countermeasures against this new tick-borne Nairovirus. (springernature.com)
  • Causative agent of these infections was Yersinia enterocolitica serogroup O:8. (medworm.com)
  • Infection rates of rodents have a significant influence on the transmission of hemorrhagic fever with renal syndrome (HFRS). (ajtmh.org)
  • The predictive risk maps based on multivariate regression model revealed that the annual variation of infection risks is small, whereas monthly variation is large and corresponded well to the seasonal variation of human HFRS incidence. (ajtmh.org)
  • The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. (hindawi.com)
  • These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection. (hindawi.com)
  • The vast majority of HPS and HFRS infections do not transfer from person to person. (rxlist.com)
  • In China, the Hantaan and Seoul viruses dominate HFRS infection, the leading rodent hosts of which are Apodemus agrarius and Rattus norvegicus , respectively [ 1 , 2 ]. (frontiersin.org)
  • Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. (ajtmh.org)
  • Results indicate that the distribution and infection rates of rodents are closely associated with environmental conditions. (ajtmh.org)
  • Hantavirus infections in rodents were positively correlated with temperature vegetation dryness index and negatively correlated with elevation. (ajtmh.org)
  • Infection is found primarily in rodents and humans. (fpnotebook.com)
  • infections also occur in rodents, lagomorphs, and domestic animals. (drugs.com)
  • The most frequent occupation was farm worker, 81% had direct and indirect contact with rodents, 91.7% of positive cases were farm workers, indicating that the probable cause of infection occurred during barn cleaning. (scielo.br)
  • Doctors usually diagnose HPS infections based on hantavirus lung symptoms are associated with rodents or probable contact with rodent-contaminated airborne dust, and chest X-rays provide additional evidence, but definitive diagnosis is usually done at a specialized lab or the U.S. Centers for Disease Control and Prevention (CDC). (rxlist.com)
  • Rodents and humans are the two primary targets of infections by hantavirus. (ebscohost.com)
  • [ 13 ] Chronic infection of small field rodents makes rural residents and farmers the most frequently infected, with a strong seasonal predominance for the fall. (medscape.com)
  • The Chilean forest service, CONAF , are hoping to expand populations of Chilean white owls and Magellanic horned owls in the Valparaíso region in an effort to increase predation on rodents and consequently reduce the risk of Hantavirus infection to people. (biomedcentral.com)
  • Most infections are asymptomatic. (bioportfolio.com)
  • In some cases the infection is asymptomatic - persons do not exhibit symptoms. (iamat.org)
  • Nonetheless, asymptomatic or oligosymptomatic hantavirus infections may occur in a higher number than in HCPS cases. (scielo.br)
  • Bluetongue viruses infect ruminants, but the clinical manifestations of infection vary considerably between hosts, ranging from completely asymptomatic to fatal. (gla.ac.uk)
  • In mild forms, infection is often asymptomatic. (merckmanuals.com)
  • They cause long-term, asymptomatic, infections in rodent reservoirs, and people become infected via the inhalation of aerosolised rodent excreta (urine, faeces, saliva). (biomedcentral.com)
  • This list (according to the GIDEON network would include: hantavirus infections - Old World, Ebola, Lassa fever, typhus - scrub, dengue, hantavirus pulmonary syndrome, and Crimean-Congo hemorrhagic fever to mention a few. (gideononline.com)
  • Hantavirus pulmonary syndrome (HPS) is a disease in which, in the late stage of infection with a hantavirus subtype, patients experience lung congestion, fluid accumulation in the lungs , and shortness of breath . (medicinenet.com)
  • Hantavirus pulmonary syndrome, also referred to as HPS, is a disease in which, in the late stage of infection with a hantavirus subtype. (rxlist.com)
  • This assay offers a new approach to evaluating and measuring neutralising antibodies produced during hantavirus infections and it can be adapted to other hantaviruses, including viruses that will be isolated in the future. (scielo.br)
  • In eastern Asia, infection with Hantaan and Seoul hantaviruses is usually diagnosed serologically with immunofluorescence assay (IFA), enzyme-linked immunosorbent assay (ELISA), or bead agglutination formats, and IgM antibody is determined by IgM capture ELISA. (asmscience.org)
  • Hantaviruses , well-characterized members of Bunyaviridae, can cause acute respiratory illness in humans. (britannica.com)
  • The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. (bioportfolio.com)
  • Most of the diseases caused by viral infection are found to be fatal, and the diagnosis is difficult due to confusion with other causative agents. (springer.com)
  • American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus Newborn (2003) Revised indications for the use of palivizumab and respiratory syncytial virus immune globulin intravenous for the prevention of respiratory syncytial virus infections. (springer.com)
  • Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (thefreedictionary.com)
  • Other diseases mentioned with a less than one percent probability include: typhoid and enteric fever, _Bunyaviridae_ infections - misc. (gideononline.com)
  • Members of the Institute for Human Infections & Immunity are University of Texas Medical Branch faculty actively engaged in the study of infectious diseases and immunity. (utmb.edu)
  • View DIVA Project profile » By using my experience in network visualization and analysis, I collaborate with researchers at the Institute for Human Infections and Immunity and the Galveston National Laboratory to analyze complex data related to infectious diseases, in addition to developing new methods that accelerate the translation of discoveries into effective treatments. (utmb.edu)
  • These newly isolated and identified mosquito-associated viruses are probably responsible for human and animal infections and diseases. (biomedcentral.com)
  • However, lots of arboviruses have been newly found and identified in mainland China, and the diseases or infections due to these newly isolated arboviruses maybe underestimated. (biomedcentral.com)
  • Bunyaviridae , Flaviviridae, and Reoviridae, we actually in Latin America do not know about this vector borne disease, it is necessary to carry out several surveys to establish the prevalence of those viruses in the vectors and humans as well. (thefreedictionary.com)
  • The 12 distinct enveloped RNA viruses that cause most viral hemorrhagic fever (VHF) cases are members of 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. (medscape.com)
  • Prior to 1956 there were no known cases of acute infections of Cache Valley virus (CVV) in humans. (wikipedia.org)
  • In addition, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia and leukocytopenia, suggesting that rhesus monkey infection resembles only a mild form of SFTSV infection in humans 20 . (nature.com)
  • Infection is transmitted to humans via inhalation of rodent excreta. (merckmanuals.com)
  • Multidrug-resistant TB Isoniazid, rifampin, streptomycin, and (MDR TB) is an infection resistant to at ethambutol least two first-line antiTB drugs, isoniazid and rifampicin Relatively uncommon disease for humans, but when left untreated, has 95% fatality rate Chloramphenicol, doxycycline, sulfisoxazole, or cotrimoxazole. (scribd.com)
  • Infection with FRV was not associated with clinical disease in animals but could potentially be disguised by other arbovirus infections , such as bovine ephemeral fever (49). (thefreedictionary.com)
  • Since 2015, Zika outbreaks have been recorded in approximately 60 countries and territories, with symptoms similar to other arbovirus infections such as Dengue. (thefreedictionary.com)
  • As in other arbovirus infections , sandfly fever may also be associated with aseptic meningitis. (thefreedictionary.com)
  • The incidences of common arbovirus infections in Latin America are very high: approximately 173 cases/100000 inhabitants for dengue, 8 cases/100000 inhabitants for chikungunya, and 45 cases/100000 inhabitants for Zika. (thefreedictionary.com)
  • little is known about the specific signaling pathways activated on microglia after arbovirus infections concurrent with prion disease. (thefreedictionary.com)
  • A network of research laboratories capable of prompt diagnosing of arbovirus infections should be developed worldwide wherever Aedes albopictus exists in order to control chikungunya. (thefreedictionary.com)
  • The primary objective is to assess the safety of telithromycin (HMR 3647) (20% fine granules) 1g filling sachet in children with infections (Respiratory tract infections, Dermatological in. (bioportfolio.com)
  • Berger A, Drosten C, Doerr HW, Sturmer M, Preiser W (2004) Severe acute respiratory syndrome (SARS)-paradigm of an emerging viral infection. (springer.com)
  • Abstract Adenoviruses are responsible for approximately 5-10% of acute respiratory infections globally. (medworm.com)
  • A chest infection usually refers to an infection of the lower respiratory tract (trachea, bronchi) and/or lungs. (healthhype.com)
  • Secondly the term is sometimes incorrectly used to refer to other non-infectious respiratory conditions that may worsen or persist after an infection. (healthhype.com)
  • Therefore a chest infection should be understood to refer to a lower respiratory tract infection (tracheitis and/or bronchitis) and/or pneumonia (lungs). (healthhype.com)
  • The flu (seasonal influenza) is a viral infection that can affect the entire respiratory tract, from the nose all the way down to the lungs. (healthhype.com)
  • However, most people with healthy immune systems do not have a severe lower respiratory tract infection with the flu. (healthhype.com)
  • Paramyxoviridae, subfamily Pneumovirinae) is the most common cause of lower respiratory tract infection in children. (powershow.com)
  • Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fully recapitulates the clinical manifestations of human infections. (nature.com)
  • Although there are growing concerns regarding the increasing SFTSV infection rates, limited information regarding its pathogenesis is currently available. (nature.com)
  • Thus, the development of an animal model that mimics severe/fatal human SFTS is crucial for understanding the pathogenesis of SFTSV and host immune response to its infection to facilitate the development of medical countermeasures, including vaccines and therapeutics. (nature.com)
  • In this study, we examined the susceptibilities of four different inbred mouse strains and an outbred ferret model ( Mustela putorius furo ) to SFTSV infection, with separate studies for young adult and aged animals, to establish an animal model of this disease. (nature.com)
  • It is critical to develop a cost-effective detection kit for rapid diagnosis and on-site detection of severe fever with thrombocytopenia syndrome virus (SFTSV) infection. (hindawi.com)
  • Here, an immunochromatographic assay (ICA) to detect SFTSV infection is described. (hindawi.com)
  • The kit showed good selectivity for detection of SFTSV-specific IgG and IgM with no interference from positive sera samples of Japanese encephalitis virus infection, Dengue virus infection, Hantavirus infection, HIV infection, HBV surface antigen, HCV antibody, Mycobacterium tuberculosis antibody, or RF. (hindawi.com)
  • Based on these results, the ICS test developed may be a suitable tool for rapid on-site testing for SFTSV infections. (hindawi.com)
  • As such, it is necessary to develop a rapid, on-site testing and easily performed assay for the detection of SFTSV infections. (hindawi.com)
  • Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus (SFTSV) from Bunyaviridae that is endemic in East Asia. (cdc.gov)
  • Mice lacking the type I interferon receptor (IFNAR −/− ) were used as an in vivo lethal model for SFTSV infection. (asm.org)
  • A host of different viral and bacterial species can be responsible for chest infections. (healthhype.com)
  • Infection of these species remains unapparent. (centerwatch.com)
  • Hantavirus infection is commonly diagnosed using serologic techniques and reverse transcription-polymerase chain reaction. (scielo.br)
  • Neutralisation assays, which are the most specific serologic tests, are not commonly used for a routine hantavirus infection diagnosis because are the tests are laborious and demand biosafety level (BSL)-3 laboratories to handle the virus. (scielo.br)
  • Laboratory diagnosis of hantavirus infection is established by serologic tests and reverse transcriptase-polymerase chain reaction (RT-PCR). (merckmanuals.com)
  • Serologic diagnosis in North America must be able to differentiate between Seoul and Sin Nombre virus infections due to potential cross-reactivity. (merckmanuals.com)
  • We report the case of a 1-week old calf with severe central nervous system (CNS) lesions probably caused by in utero infection with the new virus. (cdc.gov)
  • This study will compare the efficacy, safety and tolerability of intravenous ertapenem versus another intravenous antibiotic in the treatment of moderate to severe diabetic foot infection. (bioportfolio.com)
  • Most patients recover 4 to 7 days later, but some end up with one or more severe forms of the infection: Ocular syndrome (legions to the retina causing possible vision loss), meningoencephalitis (brain swelling causing memory loss, hallucinations, and convulsions) and /or haemorrhagic fever (uncontrolled bleeding and possible liver damage). (iamat.org)
  • This does not mean that every severe chest infection in people who are immune compromised will lead to fatal outcomes. (healthhype.com)
  • As a general rule, every chest infection even in healthy individuals should be assessed and treated by a medical professional, particularly if it is severe, persisting or worsening. (healthhype.com)
  • In severe or prolonged infections there may also be symptoms like unintentional weight loss. (healthhype.com)
  • It is often thought that bacterial chest infections are more severe. (healthhype.com)
  • Hantavirus prevalence and the human risk of infection have been linked to a number of factors including rodent population dynamics , habitat use , climate and small mammal diversity . (biomedcentral.com)
  • Human infection occurs following unusual or intense contact with infected rodent populations. (britannica.com)
  • The infection is endemic in northern, eastern, and southern Africa and outbreaks have also occurred in the Arabian Peninsula. (iamat.org)
  • A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. (freepatentsonline.com)
  • Seroprevalence study of hepatitis E virus infection in two districts of the Czech Republic. (ivb.cz)
  • To do this, we generate novel gene-knockout mice and evaluate their disease after influenza virus or vesicular stomatitis virus infection. (wustl.edu)
  • However, both IFN-deficient and mitomycin-treated mice are immunocompromised and cannot utilize the normal immune response against virus infection. (nature.com)
  • The expression of HLA class I and II molecules in infected cells is observed either increase or decrease after virus infection [ 10 - 14 ], which suggests that the HLA-related host immunity could be responsible for not only the disease progression but also the controlling infection itself. (hindawi.com)
  • The laboratory animal model for natural Sindbis virus infection and pathogenesis is the mouse, inoculated subcutaneously (s.c.) to mimic transmission by the bite of an infected mosquito. (asm.org)
  • These data suggest that the innate immune system may play a role in determining the relative permissivity of host tissues to virus infection under different circumstances. (asm.org)
  • Double-stranded RNA pattern and partial sequence data indicate plant virus infection associated with the ringspot disease of European mountain ash ( Sorbus aucuparia L. (springer.com)
  • Cache Valley virus (CVV) and Potosi virus (POTV) are two closely related mosquito-borne viruses (Bunyaviridae: Bunyamwera group) that appear to circulate in several regions of the United States, especially the Midwest. (ajtmh.org)
  • However, CVVs Bunyamwera serogroup's two non-structural proteins play an important role in infection. (wikipedia.org)
  • and RETROVIRIDAE INFECTIONS may cause this form of meningitis. (harvard.edu)
  • Systematic reviews of point-of-care tests for the diagnosis of urogenital Chlamydia trachomatis infections. (bioportfolio.com)
  • Historically the diagnosis of chorioamnionitis (an infection of the membranes surrounding the fetus) for patients in labor has been made on the basis of multiple clinical variables such as maternal fever, fetal tachycardia, uterine tenderness, or foul smelling vaginal discharge. (centerwatch.com)
  • Update 05.2 October 27 to November 3, 2005 DIAGNOSIS CLINICAL DATABASE Infectious mononucleosis or EBV infection EPIDEMIOLOGY Adenovirus infections United Kingdom AIDS Greece, Latvia Amebic colitis Kenya, Lebanon Anthrax European Region - All countries Ascariasis Kenya, Laos, Lebanon Blastocystis hominis Zambia Brucellosis European Region - All countries Bunyaviridae infections - misc. (gideononline.com)
  • Mainly, we aim to understand the determinants of BTV pathogenesis and the main factors that control the clinical outcome of BTV infection. (gla.ac.uk)
  • Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa fever, Rift Valley fever, Crimean-Congo hemorrhagic fever, and hemorrhagic fever with renal syndrome due to Old World Hantavirus infection) and should be used only under an investigational new drug (IND) protocol. (nih.gov)
  • Moreover, based on the genomic diversity of the phleboviruses and given the low correlation observed between complement fixation titers and genetic distance, we propose a system for classification of the Bunyaviridae based on genetic as well as serological data. (asm.org)
  • Evidence of Toscana virus infections without central nervous system involvement: a serological study. (microbiologyresearch.org)
  • Biogeography of tick-borne Bhanja virus (Bunyaviridae) in Europe. (ivb.cz)
  • Prophylactic ribavirin may be effective for some Bunyaviridae and Arenaviridae infections (available only as IND). (nih.gov)
  • View Department of Pathology profile » My main research interest is to better understand the mechanisms that enable emerging viruses to evade host immune responses and cause disease, and to identify cellular factors that contribute to viral infection. (utmb.edu)
  • Disease severity resulting from infection by these agents varies widely, but the most extreme manifestations include circulatory instability, increased vascular permeability, and diffuse hemorrhage. (medscape.com)
  • infection usually results in a benign febrile illness, although complications, such as ocular sequelae or fatal encephalitis and hemorrhagic disease, can occur ( 1 , 2 ). (blogspot.com)
  • It depends on the causative infectious agent, severity of the infection, immune defenses and any pre-existing conditions. (healthhype.com)
  • Cache Valley and Potosi viruses (Bunyaviridae) in white-tailed deer (Odocoileus virginianus): experimental infections and antibody prevalence in natural populations. (ajtmh.org)
  • We determined the prevalence of specific neutralizing antibodies to both viruses in Indiana white-tailed deer and conducted infection experiments to assess whether deer could serve as an vertebrate-amplifying host. (ajtmh.org)
  • Infection of adult 129 Sv/Ev mice with consensus Sindbis virus strain TR339 is subclinical due to an inherent restriction in early virus replication and viremic dissemination. (asm.org)
  • In this study, we have carried out infections of human cells with a vaccine strain (MP12) and virulent strain (ZH501) of RVFV and determined host responses to viral infection. (nih.gov)
  • WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. (bioportfolio.com)
  • Abstract Cases of autochthonous dengue virus type 1 (DENV-1) infections were detected in Japan following a 70-year period devoid of dengue outbreaks. (medworm.com)
  • Some of the pathogens have responsible for a chest infection have been listed below. (healthhype.com)
  • However, only a few of these ticks have shown to cause human infections. (encyclopedia.com)