Virus diseases caused by the BUNYAVIRIDAE.
A genus of the family BUNYAVIRIDAE containing over 150 viruses, most of which are transmitted by mosquitoes or flies. They are arranged in groups defined by serological criteria, each now named for the original reference species (previously called serogroups). Many species have multiple serotypes or strains.
Hemorrhagic Fevers, Viral
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
Viral Nonstructural Proteins
RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.
Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Janus Kinase 1
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
A genus of plant viruses in the family BUNYAVIRIDAE. Tomato spotted wilt virus is the type species. Transmission occurs by at least nine species of thrips.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Viral Envelope Proteins
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Sandfly fever Naples virus
Seroepidemiology of California and Bunyamwera serogroup (Bunyaviridae) virus infections in native populations of Alaska. (1/101)This study investigated the geographic distribution and prevalence of antibodies to California and Bunyamwera serogroup viruses in Native populations of Alaska, and demographic and ecologic risk factors associated with exposure. Sera (n = 1,635) from 18 communities were screened using an ELISA. All age groups were tested for antibodies to Jamestown Canyon (JC), Inkoo (INK), snowshoe hare (SSH), and Northway (NOR) viruses; persons > or = 45 years old (n = 90) from six communities were additionally tested for antibodies to Tahyna (TAH), Batai (BAT), Cache Valley (CV), and Sindbis (SIN) viruses. Thirty free-ranging mammals were tested by a plaque reduction neutralization test (PRNT) for antibodies to all eight viruses and to Getah (GET) virus. In Natives, overall antibody prevalence was 24.9% (JC = 17.6%, monotypic JC = 6.5%, INK = 11.1%, monotypic INK = 0.6%, SSH = 6.8%, monotypic SSH = 3.5%, and NOR = 6.2%). Five TAH, CV, and BAT virus exposures may be serologic cross-reactions, and no SIN virus antibodies were detected. Sindbis-like virus antibodies were found in 30% of the mammals. Most mammals had antibodies to NOR (83.3%) and California serogroup (70.0%) viruses; no GET virus exposures were found. Significant risk factors for human bunyavirus exposures were age group, ethnic-linguistic group, biotic province, climate zone, terrestrial vegetation, and presence of some ungulates and small mammals in communities. Sex was not a significant risk factor. (+info)
RNA binding properties of bunyamwera virus nucleocapsid protein and selective binding to an element in the 5' terminus of the negative-sense S segment. (2/101)The genome of Bunyamwera virus (BUN) (family Bunyaviridae, genus Bunyavirus) comprises three negative-sense RNA segments which act as transcriptional templates for the viral polymerase only when encapsidated by the nucleocapsid protein (N). Previous studies have suggested that the encapsidation signal may reside within the 5' terminus of each segment. The BUN N protein was expressed as a 6-histidine-tagged fusion protein in Escherichia coli and purified by metal chelate chromatography. An RNA probe containing the 5'-terminal 32 and 3'-terminal 33 bases of the BUN S (small) genome segment was used to investigate binding by the N protein in vitro using gel mobility shift and filter binding assays. On acrylamide gels a number of discrete RNA-N complexes were resolved, and analysis of filter binding data indicated a degree of cooperativity in N protein binding. RNA-N complexes were resistant to digestion with up to 1 microg of RNase A per ml. Competition assays with a variety of viral and nonviral RNAs identified a region within the 5' terminus of the BUN S segment for which N had a high preference for binding. This site may constitute the signal for initiation of encapsidation by N. (+info)
Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. (3/101)Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames. We have generated a mutant virus lacking NSs, called BUNdelNSs, by reverse genetics. Compared with the wild-type (wt) virus, BUNdelNSs exhibited a smaller plaque size and generated titers of virus approximately 1 log lower. In mammalian cells, the mutant expressed greatly increased levels of N protein; significantly, the marked inhibition of host cell protein synthesis shown by wt virus was considerably impaired by BUNdelNSs. When inoculated by the intracerebral route BUNdelNSs killed BALB/c mice with a slower time course than wt and exhibited a reduced cell-to-cell spread, and titers of virus in the brain were lower. In addition, the abrogation of NSs expression changed Bunyamwera virus from a noninducer to an inducer of an interferon-beta promoter. These results suggest that, although not essential for growth in tissue culture or in mice, the bunyavirus NSs protein has several functions in the virus life cycle and contributes to viral pathogenesis. (+info)
The Bunyamwera virus nonstructural protein NSs inhibits viral RNA synthesis in a minireplicon system. (4/101)The small (S) genomic segment of Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) encodes the nucleocapsid protein, N, and a nonstructural protein, NSs, in overlapping reading frames. In order to elucidate the function of NSs, we established a plasmid-based minireplicon system using mammalian cells that express large amounts of T7 RNA polymerase. Expression of N, the viral polymerase protein (L), and a minireplicon containing a reporter gene was sufficient to reconstitute functional virus nucleocapsids. Coexpression of NSs, however, led to a dose-dependent decrease in reporter activity without affecting expression of controls. The inhibition could not be reversed by overexpression of N, L or the minireplicon, indicating that the NSs effect was not caused by a reduction in virus gene expression. The NSs proteins of two other members of the Bunyavirus genus, Guaroa virus and Lumbo virus, were also inhibitory in our system. The intracellular localisation of Bunyamwera virus NSs was investigated and found to be predominantly cytoplasmic, but intranuclear inclusion was also detected. Taken together, these data suggest that, in mammalian cells, the bunyavirus NSs protein controls the activity of the viral polymerase by a highly conserved mechanism. (+info)
Protein synthesis in Bunyamwera virus-infected cells. (5/101)In Vero cells infected with Bunyamwera virus there is a rapid inhibition of cell RNA and protein synthesis to levels of 30 and 3% respectively of the control rate, both the rate of inhibition and the time lag before its initiation being multiplicity dependent. Using u.v.-irradiated virus, investigation of the mechanism of inhibition of host cell protein synthesis indicates that synthesis of new virus components is required for inhibition to occur. Quantitative comparison of the proteins synthesized in infected cells shows that at higher m.o.i. synthesis of virus, as well as cellular proteins, is inhibited. Bunyamwera virus-infected Vero cells synthesized three virus-specific proteins identified as the structural virion proteins. Nucleoprotein is synthesized predominantly early in infection while the major envelope glycoprotein and the minor glycoprotein are synthesized predominantly late in the infection cycle. (+info)
A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. (6/101)In late 1997 and early 1998, a large outbreak of hemorrhagic fever occurred in East Africa. Clinical samples were collected in Kenya and southern Somalia, and 27 of 115 (23%) hemorrhagic fever patients tested showed evidence of acute infection with Rift Valley fever (RVF) virus as determined by IgM detection, virus isolation, detection of virus RNA by reverse transcription-polymerase chain reaction (RT-PCR), or immunohistochemistry. However, two patients (one from Kenya and the other from Somalia) whose illness met the hemorrhagic fever case definition yielded virus isolates that were not RVF. Electron microscopy suggested these two virus isolates were members of the family Bunyaviridae. RT-PCR primers were designed to detect bunyavirus RNA in these samples. Regions of the S and L segments of the two isolates were successfully amplified, and their nucleotide sequences exhibited nearly complete identity with Bunyamwera virus, a mosquito-borne virus not previously associated with severe human disease. Unexpectedly, the virus M segment appeared to be reassorted, as the sequences detected exhibited 32-33% nucleotide and 28% amino acid differences relative to the corresponding M segment sequence of Bunyamwera virus. The association of this reassortant bunyavirus, proposed name Garissa virus, with severe disease is supported by the detection of the virus RNA in acute-phase sera taken from 12 additional hemorrhagic fever cases in the region. (+info)
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. (7/101)Production of alpha/beta interferons (IFN-alpha/beta) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence. Bunyamwera virus (BUN) is the prototype of the Bunyaviridae family. By using reverse genetics, we previously produced a recombinant virus lacking the nonstructural protein NSs (BUNdelNSs) and showed that NSs is a nonessential gene product that contributes to viral pathogenesis. Here we demonstrate that BUNdelNSs is a strong inducer of IFN-alpha/beta, whereas in cells infected with the wild-type counterpart expressing NSs (wild-type BUN), neither IFN nor IFN mRNA could be detected. IFN induction by BUNdelNSs correlated with activation of NF-kappaB and was dependent on virally produced double-stranded RNA and on the IFN transcription factor IRF-3. Furthermore, both in cultured cells and in mice lacking a functional IFN-alpha/beta system, BUNdelNSs replicated to wild-type BUN levels, whereas in IFN-competent systems, wild-type BUN grew more efficiently. These results suggest that BUN NSs is an IFN induction antagonist that blocks the transcriptional activation of IFN-alpha/beta in order to increase the virulence of Bunyamwera virus. (+info)
Polymorphism and structural maturation of bunyamwera virus in Golgi and post-Golgi compartments. (8/101)The Golgi apparatus is the assembly site for a number of complex enveloped viruses. Using high-preservation methods for electron microscopy, we have detected two previously unknown maturation steps in the morphogenesis of Bunyamwera virus in BHK-21 cells. The first maturation takes place inside the Golgi stack, where annular immature particles transform into dense, compact structures. Megalomicin, a drug that disrupts the trans side of the Golgi complex, reversibly blocks transformation, showing that a functional trans-Golgi is needed for maturation. The second structural change seems to take place during the egress of viral particles from cells, when a coat of round-shaped spikes becomes evident. A fourth viral assembly was detected in infected cells: rigid tubular structures assemble in the Golgi region early in infection and frequently connect with mitochondria. In Vero cells, the virus induces an early and spectacular fragmentation of intracellular membranes while productive infection progresses. Assembly occurs in fragmented Golgi stacks and generates tubular structures, as well as the three spherical viral forms. These results, together with our previous studies with nonrelated viruses, show that the Golgi complex contains key factors for the structural transformation of a number of enveloped viruses that assemble intracellularly. (+info)
The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on...
The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the hosts antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly degraded after reaching peak levels of expression at 12hpi. Through the use of inhibitors this was shown to be the result of proteasomal degradation. A recombinant virus (rBUN4KR), in which all four lysine residues in NSs were replaced by arginine residues, expresses an NSs protein (NSs4KR) that is resistant to degradation, confirming that degradation is lysine-dependent. However, despite repeated attempts, no direct ubiquitylation of NSs in infected cells could be demonstrated. This suggests that degradation of NSs, although lysine-dependent, may be achieved through an indirect mechanism. Infection of cultured mammalian cells or mice indicated no disadvantage for the virus in having a non-degradable NSs protein: in fact rBUN4KR had a slight growth ...
Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses. | Journal of Virology
A cDNA containing the complete coding sequence of the Bunyamwera virus (family Bunyaviridae) L genome segment has been constructed and cloned into two recombinant vaccinia virus expression systems. In the first, the L gene is under control of vaccinia virus P7.5 promoter; in the second, the L gene is under control of the bacteriophage T7 phi 10 promoter, and expression of the L gene requires coinfection with a second recombinant vaccinia virus which synthesizes T7 RNA polymerase. Both systems express a protein which is the same size as the Bunyamwera virus L protein and is recognized by a monospecific L antiserum. The expressed L protein was shown to be functional in synthesizing Bunyamwera virus RNA in a nucleocapsid transfection assay: recombinant vaccinia virus-infected cells were transfected with purified Bunyamwera virus nucleocapsids, and subsequently, total cellular RNA was analyzed by Northern (RNA) blotting. No Bunyamwera virus RNA was detected in control transfections, but in cells ...
Proteins and Glycoproteins Specified by Bunyamwera Virus and by Belmont Virus, a Possible Bunyavirus, in Mammalian Cells |...
Summary Purified preparations of Belmont virus were shown to be very similar morphologically and biochemically to those of Bunyamwera virus. Comparisons of the synthesis of virus-specifed proteins in Vero and BHK-21 cells confirm the close taxonomic relationship. Total protein synthesis was inhibited 95% by 23 h post-infection with Belmont virus; a similar reduction occurred earlier in Bunyamwera virus-infected cells. This inhibition was multiplicity dependent, and synthesis of the host protein component was inhibited more severely. When cells were labelled late during infection at an m.o.i. of 1, the four structural proteins were readily resolved by gel electrophoresis. A small possibly non-structural protein (p14 for Belmont, p13 for Bunyamwera) was also identified late in infection in both hosts. As in the virion, the small envelope protein (P28) of Belmont virus was not glycosylated, whereas the large envelope protein G107, and the corresponding G1 and G2 of Bunyamwera virus, were labelled
British Library EThOS: Impact of interferon β and interferon stimulated gene induction on Bunyamwera virus replication
The first line of defence against viral infection is the interferon (IFN) response, which must be overcome by a virus for successful replication. Pattern recognition receptors detect virus which triggers induction of IFNβ. Secreted IFNβ stimulates the JAK/STAT signal transduction pathway and the upregulation of IFN stimulated genes (ISGs) culminating with expression of hundreds of antiviral proteins. Bunyamwera virus (BUNV) is the prototype virus for the genus Orthobunyavirus and the family Bunyaviridae. BUNV is a trisegmented single stranded negative sense RNA virus whose genome comprises the Large (L), Medium (M) and Small (S) RNA segments. The L segment encodes the RNA polymerase, the M segment the two glycoproteins Gn and Gc and a non-structural protein NSm, and the S segment the nucleoprotein and a non-structural protein NSs in overlapping reading frames. The NSs protein interferes with RNA polymerase II mediated transcription thereby inhibiting cellular mRNA production, including IFN ...
L - RNA-directed RNA polymerase L - Bunyamwera virus (BUNV) - L gene & protein
RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism. It consists in the hijacking and cleavage via N-terminal endonuclease activity of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. The 3-end of subgenomic mRNAs molecules are not polyadenylated. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated.
Cache Valley virus - Wikipedia
Cache Valley virus (CVV) is a member of the Bunyavirales order, Orthobunyavirus genus, and Bunyamwera serogroup, which was first isolated in 1956 from Culiseta inornata mosquitos collected in Utahs Cache Valley. CVV is an enveloped arbovirus, nominally 80-120 nm in diameter, whose genome is composed of three single-stranded, negative-sense RNA segments. The large segment of related bunyaviruses is approximately 6800 bases in length and encodes a probable viral polymerase. The middle CVV segment has a 4463-nucleotide sequence and the smallest segment encodes for the nucleocapsid, and a second non-structural protein. CVV has been known to cause outbreaks of spontaneous abortion and congenital malformations in ruminants such as sheep and cattle. CVV rarely infects humans, but when they are infected it has caused encephalitis and multiorgan failure. The Cache Valley Virus genome is split into three parts. The three parts are called the small, medium, and large segments, based on the number of ...
Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus | Journal...
Morphological changes of nucleoli were long known as a hallmark of orthobunyavirus infection (60). Moreover, recently a nucleolar localization sequence important for NSs action was described for the orthobunyavirus SBV (45). Our findings that Elongin C (i) colocalizes with nucleolin in uninfected cells, (ii) contributes to the NSs-mediated RNAP II degradation, and (iii) becomes redistributed in the presence of NSs are in line with those earlier observations. Thus, Elongin C appears to be a player in the anti-IFN strategy of LACV, a view further underscored by the increase in IFN induction and RNAP II activity by, log10 step in Elongin C-deficient cells that were infected with wt LACV.. The cellular Elongin complex consisting of Elongin A, B, and C is able to foster both the elongation of mRNA transcription by RNAP II (56) and (the B/C complex) the degradation of RPB1 under conditions of stress (53-55). These activities are congruent with the action of orthobunyavirus NSs, which targets exactly ...
cache valley virus - Image - Digital Journal
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Fall Prevention Series Part 2: Belmonts In-house Rehab Teams offer Expert Care & Support after a Fall - Belmont Village
Falls are an all-too common occurrence among seniors, and the causes of falls can vary widely-from biological factors like changes in eyesight or hearing to environmental ones, such as missing a step or tripping on a rug.. While Belmont Village is in the process of piloting a new fall-prevention program with TIRR Memorial Hermann at our West University and Hunters Creek communities this summer, all Belmont Village communities take proactive measures to prevent falls-starting from the first day residents arrive.. Prevention Starts from Day One. Upon move-in, Belmont Villages teams evaluate each resident closely to determine the full continuum of care each resident requires. This includes evaluating levels of fitness, such as agility and range of motion, as well as questionnaires to determine seniors confidence in tending to their own self-care. This baseline is then used to provide ongoing monitoring and care.. To reduce the chance of falls, Belmont Village partners with professional ...
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MILE-AND-ONE-EIGHTH BELMONT STAKES TO BE RUN JUNE 20 - Horse Race Insider
For once were on the same page, TJ, but Id have felt the same about any change in distance.. The above announcement is yet another example of the short-sighted, self-serving thinking that plagues American Thoroughbred racing.. Does this decision actually allay the fears of horsemen reluctant to compete in a delayed first leg of the Triple Crown at a different venue with the most demanding distance?. The setting sequence switches could have been avoided with cooperation. Churchill Downs and Pimlico are gambling that the disease can be managed without another infection wave so that live attendance will eventually be allowed. Belmont has chosen to conduct their event while the window of opportunity still exists which should have been to their credit.. Regardless of where and when the race is viewed, NYRA was obligated to maintain the quality of their product for its customers as well as for the contestants and their connections. The Belmont Stakes is an industry cornerstone; built on its ...
Kimberly-Clark closes Belmont molding plant, eliminates 180 jobs | 2013-01-09 | Grand Rapids Business Journal
The Kimberly-Clark Professional molding plant in Belmont that produces highway work zone safety products will close in June, resulting in the loss of about 180 jobs here, according to an announcement from Kimberly-Clark in Dallas. Meetings were conducted earlier this week with the 180 employees who work at the Belmont facility to notify them of the plans to close the mill, according to a statement from Bob Brand of the Kimberly-Clark Corp. communications department. Brand said eligible employees will receive a severance package, and Kimberly-Clark Professional . . .
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Belmont Stakes Results 2014: Review of Race Chart, California Chrome Highlights | Bleacher Report
The crowd of over 100,000 at Elmont was once again on its feet with a huge roar, ready to see history. Each fan in Belmont Park anticipated a triumph like many had never seen in their lifetimes...
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September 23, 2020
BABA President:. Constance Ihrke Email: [email protected] Meetings: Second Thur, 9 am. Historic Belmont Firehouse,. 900 SE 35th. www.belmontbusiness.org. Be a member: Belmont Area Business Association is having a great beginning of the new year with a strong start to the annual membership drive.. Mix and mingle: Buy your tickets for the Belmont Area Business Association Annual Dinner taking place Thursday, February 20 at Tabor Space, 5441 SE Belmont St. Great food, silent auction and business networking. $20 per person or two guests for $35.. Buy tickets read about membership and join online at: www.belmontdistrict.org. Yoga for kids: BABA member business Shakti House at 1401 Morrison is excited to be offering special kids acroyoga workshops: 5-8 year olds on 3-4 and 9-13 year olds 4:30-5:30 pm Saturday, February 1.. For other classes and programs and registration information: shaktihousepdx.com.. ...
Belmont Stakes Up for Grabs to End Uneven Triple Crown - NBC Chicago
This years topsy-turvy Triple Crown trail comes to an end in a Belmont Stakes without the Kentucky Derby and Preakness winners or the expected favorite who dropped out. It does come with questions about...
Molars and makeovers: Dentists photo shoots highlight new smiles - News - Belmont Citizen-Herald - Belmont, MA
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Tiz the Law wins 152nd Belmont Stakes in first of Triple Crown | wzzm13.com
Favored Tiz the Law has won the 152nd Belmont Stakes in a race thats the first to open the Triple Crown rescheduled during the coronavirus pandemic.
Daytonian in Manhattan: The 1909 Lost Belmont Mansion -- No. 477 Madison Avenue
Of all the many photos I have ever seen of Alva Belmont, the 1905 depiction in Era Magazine that you have published is the only one that makes her look vaguely attractive. All of her other likenesses bring to mind an oft told Gilded Age story: apparently, Alva Vanderbilt marched up to the notoriously sharp tongued Mrs. Stuyvesant Fish (no beauty herself , at least as depicted in photographs), and said, Mamie. You cant deny it. Everyone heard you. You told your guests at dinner last night that I look like a frog. Mrs. Fish is reported to have replied, that is not true. I told everyone that you look like a toad. And right she was. Great post, as always, by the way. I have seen other photos of the interiors of the house. It was quite an eclectic mix- from the neo-Federal, to the pseudo-Gothic with all the Beaux art Louis styles also represented.. ReplyDelete ...
Ares Marlonsson - Belmont Bruins
Statistics: 2018 , 2017. 2017: Scored a goal against Niagara (8/27)... Recorded a shot in every game played... Appeared in three games before redshirting due to injury... Prior to Belmont: Played freshman and sophomore seasons for head coach Aaron Smith at Horizon High School... Played for the Colorado Rush for head coach Sean Bushey.... Personal: Majoring in Neuroscience with an interest in artificial intelligence... ...
Milestones Child Development Center | Child Care Services | Ada - Cascade - Forest Hills News
Our certified and degreed teachers serve as role models and encompass positive images of children, recognizing that they are capable of many things. With this in mind, our staff constantly encourages children to reach new potentials. Teachers embody the roles of facilitators, observers, evaluators, and providers of a warm, nurturing environment.. Parents are encouraged to become involved with their childs education by taking the responsibility of assisting their child in growing to his or her fullest potential. We believe it is essential for parents, teachers, and families to work as a team with a common goal to continually develop and increase childrens knowledge and growth.. We also have locations in Hastings, Belmont and ADA/Cascade:. HASTINGS: 269-945-5855. 1150 West M-43 Highway, Hastings, MI 49058. BELMONT: 616-361-0191. 2370 Belmont Center Dr., Belmont, MI 49306. ADA/CASCADE: 616-942-5002. 5070 Cascade Road SE, SUITE #100, Grand Rapids MI 49546. ...
Gay, Female, 59 - Looking in Belmont, Highton & Sout... | Flatmates.com.au
I am looking for Granny Flat / room only on a weekly basis with bed until I find my way around and get feel for it, outer Geelong not near the city, Belmont Highton towards the coast area etc.. then I will find my own place. So if you can help me I appreciate it...I have some Health problems and am mature age 59, relocating to be near my Son and Doctors....Non smoking house, no stairs, must have off st parking or in back yard as my car will will be packed to the brim, so obvious to the eyes. prefer to stay with 1 other female... Prefer someone my age but not essential, I am easy to get on with. ...
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Former Cubs Pitcher Kerry Wood Reportedly Finds Body in Belmont Harbor | Bleacher Report
Former Chicago Cubs pitcher Kerry Wood reportedly found the body of a dead man while paddle boarding in the citys Belmont Harbor on Monday...
Belmont auction: Buyer plans development after kids finish school
A THREE-bedroom Belmont home provides a significant upside for a farming family preparing to move off the land while their school-aged kids complete their education.
NY-bred Tiz the Law wins barren Belmont Stakes
Tiz the Law won an unprecedented Belmont Stakes, claiming victory Saturday at the first race of a rejiggered Triple Crown schedule in front of eerily empty grandstands.
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Palo Alto flasher may have struck again in Belmont - SFGate
A man being sought for flashing women and girls in three incidents in Palo Alto may have struck again Friday in Belmont, police said. The most recent incident happened about 3:30 p.m. Thursday when a man in a BMW came to a stop in front of a woman riding her bicycle on Miller Avenue. In the two earlier incidents this week, two girls, ages 10 and 14, reported that they were the victims of indecent exposure.
Ocala-bred Tapwrit rallies in stretch to win Belmont Stakes - Sports - - Gainesville, FL
The three-year old colt, who was broken at Bridlewood Farm in Ocala, finished sixth in the Kentucky Derby and skipped the Preakness. Five of the last nine Belmont winners followed that same path.
Royal Delta Grazes at Belmont Park 6/6/2013 - Video - - BloodHorse
Champion Royal Delta, who will defend her title in the June 15 Fleur de Lis at Churchill Downs, grazes outside Hall of Fame trainer Bill Motts barn at Belmont June 6. ...
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Belmont North Carolina genetic screening program
Get the facts about Belmont NC genetic screening program. Nursing is one of the fastest-growing job areas, and for good reason. As the population ages, medical care will continue to expand rapidly.
Room for Rent in Edith Court, Belmont, Geelong | $16... | Flatmates.com.au
Im looking to rent a room in Belmont. Looking for someone clean, tidy and reliable. I consider myself easy to live with. I work full time during the ...
H. Michael Belmont | NYU Langone Health
Meet doctor H. Michael Belmont, MD, Rheumatologist, and learn about conditions treated, training, and research at NYU Langone. Read more.
Another Triple Crown surprise: Sir Winston takes Belmont | The Spokesman-Review
Sir Winston gave the Triple Crown another unexpected turn, rallying in the stretch to capture the Belmont Stakes in a 10-1 upset. The win gave trainer Mark Casse the final two jewels of the showcase for 3-year-old thoroughbreds.
Belmont Stakes: Exaggerator Faces Talented Field Of Twelve - CBS Philly
While the Belmont wont have the excitement of a re-match between Nyquist and Exaggerator, it will include a field of talented colts to challenge the Preakness winner.
Belmont, CA Events Tomorrow | Eventbrite
Lining up plans in Belmont? Whether youre a local, new in town, or just passing through, youll be sure to find something on Eventbrite that piques your interest.
Belmont Stks DogsUp Delta Details [horse racing 990.99]
Horse Racing Forum - Belmont Stks DogsUp Delta Details - DogsUpBigE said: But most of all enjoy the trip Preaching to the choir, Dogs. Once the realization arises that life is a gift, gratitude arises with it. Onward & upward!
2018 Belmont Stakes: Odds, post positions as Justify goes for Triple Crown
Complete information from the post position draw on the 2018 Belmont Stakes, as Justify looks to become the 13th Triple Crown winner
Common ownership clouds Audibles status for Belmont Stakes
Trainer Todd Pletcher, who has won two of the last five Belmont Stakes, will once again be a participant in the race this year. How many runners he has, however, will depend upon decisions that will be forthcoming from his owners.
Belmont Stks DogsUp Delta Details [horse racing 990.96]
Horse Racing Forum - Belmont Stks DogsUp Delta Details - I am a Ranger fan, so hes one of my favorites. Struck out four men in an inning several times, because of that dreaded passed ball on a third strike!