Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
A microcomputer-based software package providing a user-friendly interface to the MEDLARS system of the National Library of Medicine.
The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
A plant genus of the family LILIACEAE that is a short plant with a distinct whorl of 3 broad leaves.
The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
A particular type of FEMUR HEAD NECROSIS occurring in children, mainly male, with a course of four years or so.
An American National Standards Institute-accredited organization working on specifications to support development and advancement of clinical and administrative standards for healthcare.
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.

Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. (1/125)

Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various lines of human tumor cells, such as leukemia HL60 and U937 cells, by altering the expression of apoptosis-related genes, for example, bcl-2 and c-myc. In this study, we characterized a gene that is involved in bufalin-induced apoptosis by the differential display (DD) technique. The partial nucleotide sequence of one of the differentially expressed clones obtained after treatment with bufalin was identical to that of the human gene for Tiam1. When U937 cells were treated with 10(-7) M bufalin, expression of both Tiam1 mRNA and the protein was induced 1 h after the start of the treatment. The increase of Tiam1 mRNA was transient but the level of Tiam1 protein continued to increase at least for 6 h. In addition, the activities of Rac1 and p21-activated kinase (PAK) were also stimulated by bufalin treatment. To evaluate the role of Tiam1 in the apoptotic process, we examined the effects of the expression of sense and antisense RNA for Tiam1 in U937 cells. Apoptosis was strongly induced by bufalin in cells that expressed sense RNA for Tiam1 as compared to apoptosis in control cells treated with bufalin only. Cells expressing antisense RNA for Tiaml were significantly more resistant than the control bufalin-treated cells to induction of DNA fragmentation in response to bufalin. Moreover, sense transformants had elevated activities of PAK and c-Jun NH2-terminal kinase (JNK). These results suggest that Tiaml might play a critical role in bufalin-induced apoptosis through the activation of Rac1, PAK, and JNK pathway.  (+info)

Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. (2/125)

To identify genes that are differentially expressed by Na+, K+-ATPase inhibitors, we used the differential display technique to compare mRNA expression patterns in rat lens. Lenses were treated with 10 microM ouabain, bufalin, or 19-norbufalin derivative for 24 h and were compared with control lenses. Differential display analysis revealed that one of the down-regulated genes was 14-3-3 theta. Down-regulation was confirmed by Northern blot and by reverse transcription-polymerase chain reaction analysis. Reverse transcription-polymerase chain reaction of additional 14-3-3 isoforms revealed that the eta and gamma isoforms of 14-3-3 are also down-regulated by ouabain, bufalin, and 19-norbufalin derivative, whereas the zeta isoform is down-regulated only by bufalin. Down-regulation of the 14-3-3 isoforms occurred without a significant change in gamma-crystallin gene expression. These results demonstrate that one of the consequences of Na+, K+-ATPase inhibition by exogenous or endogenous inhibitors is the down-regulation of mRNA transcripts encoding several isoforms of 14-3-3. Because the 14-3-3 proteins are multifunctional regulatory proteins, the reduction in the abundance of various isoforms will have profound effects on cell function.  (+info)

Induction of apoptosis by bufalin in human tumor cells is associated with a change of intracellular concentration of Na+ ions. (3/125)

In an attempt to characterize the mechanisms that are operative at the early stages of the induction of apoptosis by bufalin, a component of the traditional Chinese medicine chan'su, we examined the effects of bufalin on plasma membrane potential, as determined by monitoring the uptake by cells of rhodamine 123. Bufalin induced apoptosis in human monocytic leukemia THP-1 cells, in human lymphoblastic leukemia MOLT-3 cells, and in human colon adenocarcinoma COLO320DM cells but not in normal human leukocytes, for example, polymorphonuclear cells and lymphocytes, and not in murine leukemia P388D1 and M1 cells. Treatment for 3 h with bufalin at 10(-6) M caused a decrease in the plasma membrane potential in several lines of human tumor cells but not in murine leukemia cells. No changes in mitochondrial membrane potential, as monitored with the fluorescent dye JC-1, and no release of cytochrome c were observed within at least 6 h after the start of treatment with bufalin. Moreover, overexpression of bcl-2 in human leukemia HL60 cells that had been transfected with cDNA for bcl-2 prevented bufalin-induced apoptosis but had no significant effect on the change in plasma membrane potential induced by bufalin. Since bufalin specifically inhibits the Na+,K(+)-ATPase of human but not murine tumor cells, and since this inhibition leads to a change in intracellular concentration of Na+ ions, our findings suggest that bufalin induces apoptosis in human tumor cells selectively via inhibition of the Na+,K(+)-ATPase, which acts upstream of the bcl-2 protein.  (+info)

ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. (4/125)

Treatment of human leukemia THP-1 cells with bufalin, a specific inhibitor of Na(+)-K(+)-ATPase, sequentially induces c-fos and inflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) gene expressions before the appearance of mature phenotypes of monocytic cells. In this study we examined the signal transduction leading to bufalin-induced gene expressions. Bufalin selectively activated extracellular signal-regulated kinase (ERK), compared with other mitogen-activated protein (MAP) kinase family members. Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin. Inhibition of the Na(+)/Ca(2+) exchanger by KB-R7943 and of protein kinase C (PKC) by Ro-31-8220 suppressed ERK activation and gene expressions of c-fos and IL-1 beta. These findings suggest that Na(+)-K(+)-ATPase inhibition by bufalin induces calcium influx and thereby activates PKC and ERK. In cells treated with an inhibitor of p38 MAP kinases, SB-203580, bufalin-mediated ERK activation became persistent and the induction of IL-1 beta and TNF-alpha expressions was significantly augmented. These results suggest that cross talk in bufalin-mediated ERK activation is negatively regulated by endogenous p38 MAP kinase activations.  (+info)

New insecticidal bufadienolide, bryophyllin C, from Kalanchoe pinnata. (5/125)

Two insecticidal bufadienolides (1 and 2) were isolated from a methanol extract of the leaves of Kalanchoe pinnata by bioassay-guided fractionation. Compound 1 was identified as known bryophyllin A (bryotoxin C). The structure of new bufadienolide 2, named bryophyllin C, was determined by spectroscopic methods and the chemical transformation of 1. Compounds 1 and 2 showed strong insecticidal activity against third instar larvae of the silkworm (Bombyx mori), their LD50 values being evaluated as 3 and 5 microg/g of diet, respectively.  (+info)

Positive and negative interference of the Chinese medicine Chan Su in serum digoxin measurement. Elimination of interference by using a monoclonal chemiluminescent digoxin assay or monitoring free digoxin concentration. (6/125)

An over-the-counter Chinese medicine, Chan Su, is used as a cardiotonic agent. We demonstrated significant digoxin-like immunoreactivity in various organic and aqueous extracts of Chan Su. For example, when a 20-microL aliquot of an aqueous extract of Chan Su powder (1 mg/mL) was added to a 2-mL aliquot of a drug-free serum, the observed digoxin-like immunoreactivity was 2.76 ng/mL (3.53 nmol/L) digoxin equivalent using the fluorescence polarization immunoassay (FPIA). The magnitude of interference was much lower (0.94 ng/mL [1.20 nmol/L]) with the microparticle enzyme immunoassay (MEIA), and no interference was observed with the chemiluminescent assay (CLIA). We also observed a significant positive interference of the extract with the serum digoxin measurement using FPIA. In contrast, we observed a negative interference (falsely lowered digoxin concentration) of the extract in the serum digoxin measurement with the MEIA. The extract had no effect on the serum digoxin measurement with the CLIA. By taking advantage of the high protein binding of Chan Su and only 25% protein binding of digoxin, we further demonstrated that positive interference of Chan Su in the FPIA and negative interference of Chan Su in the MEIA of digoxin could be eliminated by monitoring the free digoxin concentration.  (+info)

Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that Is independent of cholesterol side-chain cleavage. (7/125)

An increasing body of evidence suggests that an endogenous mammalian bufadienolide (BD) may be involved in the regulation of Na(+),K(+)-ATPase activity and the pathogenesis of arterial hypertension. We developed a purification scheme for marinobufagenin (MBG), an amphibian cardiotonic BD, and applied it to purify and characterize material in human plasma, culture medium conditioned by Y-1 adrenocortical cells, and rat adrenal tissue. MBG immunoreactivity purified from plasma and measured by ELISA showed important similarities (chromatography and antibody cross-reactivity) to material secreted into cell culture medium by Y-1 cells. This observation indicates that circulating mammalian BD may have an adrenocortical origin. Release of mammalian BD from adrenocortical cells grown in the absence of exogenous cholesterol was reduced by treatment of cultures with mevastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Supplementation of the serum and cholesterol-free cell culture medium with the LDL fraction of human plasma increased the production of MBG material in the presence of mevastatin, supporting its origin from cholesterol. We used Y-1 cell lines transfected with genes shown to inhibit steroidogenesis through cholesterol side-chain cleavage (Y-1/DAX and Y-1/RIAB) to investigate the dependence of MBG biosynthesis on side-chain cleavage. Our results indicate that the mammalian BD is synthesized in the adrenal cortex from cholesterol and shares important similarities with the amphibian BD MBG, that its biosynthesis is independent of transfer of cholesterol to the side-chain cleavage enzyme complex mediated by steroidogenic acute regulatory protein, and that neither cAMP nor protein kinase A appears to be a critical component of the pathway controlling its biosynthesis.  (+info)

Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. (8/125)

Na+,K+-ATPase activity in the epithelial layer is fundamental to the maintenance of ionic concentration gradients and transparency of the lens. Recently we have identified endogenous digitalislike compounds (DLC), 19-norbufalin and its peptide derivatives, in human cataractous lenses (Lichtstein et al. Eur J Biochem 216: 261-268, 1993). Lenses were treated with 10 nM ouabain, bufalin or 19-norbufalin derivative for 24 h and were compared to control lenses. Differential display analysis revealed that one of the down-regulated genes was 14-3-3 theta. Down-regulation was confirmed by Northern blot and by RT-PCR analysis. RT-PCR of additional 14-3-3 isoforms revealed that the eta and gamma isoforms of 14-3-3 are also down-regulated by ouabain, bufalin and 19-norbufalin derivative, whereas the zeta isoform is down-regulated only by bufalin. These results demonstrate that one of the consequences of Na+,K+-ATPase inhibition by exogenous or endogenous inhibitors is the down-regulation of mRNA transcripts encoding several isoforms of 14-3-3. Since the 14-3-3 proteins are multifunctional regulatory proteins, the reduction in the abundance of various isoforms will have profound effects on cell function. Furthermore, These results, together with the demonstration of digitalislike compounds in the normal lens, and their increased level in human cataractous lenses, strongly suggests their involvement in the molecular mechanisms responsible for cataract formation.  (+info)

Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest. The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides,[citation needed] and the saturated equivalent is bufanolide. According to MeSH, bufadienolides and bufanolides are classified as follows: Polycyclic compounds ...
Abstract Spironolactone has been noted to attenuate cardiac fibrosis. We have observed that the cardiotonic steroid marinobufagenin plays an important role in the diastolic dysfunc..
Preeclampsia (PE) complicates from 5 to 10% of pregnancies and it is a number one cause of maternal and fetal morbidity and mortality worldwide. Nevertheless, a specific and highly effective therapy of this disorder does not exist. As illustrated by therapeutic efficacy of anti-digoxin antibody (DIGIBIND) in preeclampsia, endogenous digitalis-like sodium pump ligands play an important role in the pathogenesis of this syndrome. Previously, we demonstrated that levels of endogenous bufadienolide Na/KATPase inhibitors are elevated in patients with PE, and that antibody to marinobufagenin lower blood pressure in rats with pregnancy-induced hypertension and ex vivo reverse inhibition of the Na/K-ATPase from erythrocytes from patients with PE. Most recently, we developed three anti-MBG monoclonal antibodies which in lower blood pressure in several rat experimental models.. We are proposing a pilot proof-of concept study aimed to demonstrate that MBG is target for DIGIBIND in preeclampsia. If ...
Glentham Life Sciences is a supplier of GP1238 - Resibufogenin (465-39-4). Find catalogue prices, chemical data, technical specifications and MSDS documents.
Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of function of the maternal UBE3A gene. The hippocampus is one of the most prominently affected brain regions in AS model mice, manifesting in severe hippocampal-dependent memory and plasticity deficits. Previous studies in AS mice reported an elongated axon initial segment (AIS) in pyramidal neurons (PNs) of the hippocampal CA1 region. These were the first reports in mammals to show AIS elongation in vivo. Correspondingly, this AIS elongation was linked to enhanced expression of the α1 subunit of Na+/K+-ATPase (α1-NaKA). Recently, it was shown that selective pharmacological inhibition of α1-NaKA by marinobufagenin (MBG) in adult AS mice rescued the hippocampal-dependent deficits via normalizing their compromised activity-dependent calcium (Ca+2) dynamics. In the herein study, we showed that a chronic selective α1-NaKA inhibition reversed the AIS elongation in hippocampal CA1 PNs of adult AS mice, and differentially altered
This study will investigate the effects of anti-digoxin polyclonal antibody [DIGIBIND] on marinobufagenin levels in pregnant women with preeclampsia.
Cardiovascular disease is the main cause of death among ESRD patients. However, this excess cardiovascular mortality in ESRD patients should not be mainly attributed to coronary artery disease or myocardial infarction. The 4D study and other studies have…. ...
Sigma-Aldrich offers abstracts and full-text articles by [Xiao-Liang Wang, Guang-Hou Zhao, Jin Zhang, Qi-Yun Shi, Wei-Xiao Guo, Xiu-Li Tian, Jia-Zhang Qiu, Li-Zi Yin, Xu-Ming Deng, Yu Song].
Despite this reclassification, abnormalities of cardiac structure or function are still frequent when CMR is performed in ESRD. In a pivotal study of 134 patients who had been undergoing renal replacement therapy for an average duration of 12 months, CMR with gadolinium (Gd) contrast agents was performed on the post-dialysis day or at dry weight for peritoneal dialysis (9). The most frequent abnormality detected was LVH (72%), with comparatively low rates of LV dilation (11%) and LV systolic dysfunction (8%). The importance of an accurate, volume-independent measure of cardiac mass is paramount, given that LVH is a strong independent risk factor for mortality, cardiac arrhythmia, and heart failure in patients undergoing dialysis (10). However, the categorization of patients as having LVH is not a biological dichotomy; LV mass is a continuous variable with a graded relationship with cardiovascular risk. This is reflected by improved cardiovascular outcomes with LV mass regression when both LV ...
So usually you have 2-3 groups, group1 LM, group2, BS, group3 farm, or group 1 defend flag, group 2 get flag, something along those lines. My thesis is that, a RBG team that consists of 2 or 3x 5 man arena teams, could beat any RBG team without players being so accustomed to another. So in example: If 5 people defend farm, and 5 who all are in the same arena team attack, the attackers will win the fight. Has anyone tested this to a certain extend?
Ive been deliberately waiting to weigh in on this discussion - , however, my thoughts are as follows: , , 1.) Marking a module as deprecated is *not* the same thing as moving , it out of the code base. It simply means that there is no maintainer, , and something better exists in the code base to move to. , , 2.) Code areas marked as deprecated usually dont have a fixed sunset , point where the code is actually removed, which is what I think Dan , might have been pushing for. , , 3.) In order to move forward with any sort of deprecation process, in , my mind we need to ensure that chan_pjsip has considerable, if not , complete, feature parity with chan_sip. , , 4.) I also feel like the plan to make chan_pjsip capable of reading , sip.conf and perhaps even the chan_sip realtime tables a necessary , prerequisite for code removal, and perhaps even marking of the module , as deprecated. , , 5.) I think talk of pulling chan_sip completely out right now is , premature and probably freaking a lot of ...
Bœ̆ng Bêk Chan local information and maps. Bœ̆ng Bêk Chan is a lake in Kâmpóng Chhnăng, Cambodia, Asia. Boeng Bek Chan is also known as Beng Bek Chan.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Khine Myat Thar: 55: Khine Thant Kyaw: 56: Khine Zin Thet: 57: Khit Pyo Phyu: 58: Khit Ta Yar Sein Wah: 59: Khoon Cho Nyein Chan: 60: Khu Khu: 61: Khun Cho Nyein Chan: 62: Khwar Nee: 63: Kin Wun Min Gyi: 64: Klash Chan Dar: 65: Ko (University) 66: Ko Arkar (S/W and H/W) 67: Ko Jay: 68: Ko Ko (Set Mhu Tet Ka Tho) 69: Ko Ko Gyi: 70: Ko Ko Latt .... Learn More ...
The Chan Zuckerberg Initiative just announced a new program informally called Chan Zuckerberg Science to invest $3 billion over the next decade to help cure, prevent, or manage all disease. The money comes from the $45 billion organization Mark Zuckerberg and his wife Priscilla Chan started last year to advance human potential and equality. The project will bring together teams of scientists and engineers
Several times, dozens in the crowd broke out into song, singing Amazing Grace and This Land is Your Land as others embraced one another and wiped tears from their eyes. At one point, the crowd broke into a thunderous applause - lasting for about a minute - for Ginsburg.. Thank you RBG, one sign read. On the sidewalk, RBG was drawn inside a pink chalk heart.. Jennifer Berger, 37, said she felt compelled to join the large crowd that gathered to pay tribute to Ginsburgs life.. I think it is important for us to recognize such a trailblazer, she said. It is amazing to see how many people are feeling this loss tonight and saying goodbye.. Ginsburg spent her final years on the bench as the unquestioned leader of the courts liberal wing and became something of a rock star to her admirers. Young women especially seemed to embrace the courts Jewish grandmother, affectionately calling her the Notorious RBG, for her defense of the rights of women and minorities.. ...
Jack Chan is the editor of Simply Profits, established in 2006. Chan bought his first mining stock, Hoko Exploration, in 1979, and has been active in the markets for the past 37 years. Technical analysis has helped him filter out the noise and focus on the when, and leave the why to the fundamental analysts. His proprietary trading models have enabled him to identify the
Evolutionary.org Hardcore #114 - Jackie Chan Steroid Cycle https://www.evolutionary.org/evolutionary-org-hardcore-114-jackie-chan-steroid-cycle/
AFTER a frantic Friday night of discussion, Bafana Bafana won their battle against Kaizer Chiefs and Wits and both PSL clubs have agreed to release their combined nine players for this months African Nations Championship (Chan), which begins in Cape Town on Saturday...
Fingerprint Dive into the research topics where Shih-Huang Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Fingerprint Dive into the research topics where Andrew Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Super Milk Chan Flash is currently unavailable to stream on-demand, but may be available on Hulu with Live TV depending on regional availability. Try Live TV for free.
Mahabohi Sunyatas Buddha Dharma site of Original Chan and Dao in ENGLISH. More than just a web page, it teaches and explores the Dharma and rejects the modern isms that make the original methods ineffective. También hay enseñanzas disponibles en español sobre el Buddha Dharma para principiantes.
|Currently Online| US - Sargeras - Alliance/Area 52 - Horde - Is recruiting players for 11 raid teams, 3 RBG teams, and social/casual players of all...
Respiratory Medical Associates Layanan Spesialis Bagi Paru-Paru Anda Respiratory Medical Associates merupakan suatu klinik spesialis yang mendiagnosa dan merawat kelainan paru. Kelainan ini dapat berupa batuk yang tak kunjung sembuh, bercak pada dada pada pemeriksaan X-ray hingga infeksi paru seperti bronkitis,
Li, T. N., Wu, Y. J., Tsai, H. W., Sun, C. P., Wu, Y. H., Wu, H. L., Pei, Y. N., Lu, K. Y., Yen, T. T. C., Chang, C. W., Chan, H. L., Tao, M. H., Liou, J. Y., Chang, M. D. T., Su, I. J. & Wang, L. H. C., 2018 八月, 於 : Journal of Pathology. 245, 4, p. 502-513 12 p.. 研究成果: Article ...
After all. In a recent report bittorrent traffic is down in the US, while going up in Europe (yet overall bandwidth usage in the US has stayed relatively the same). That bespeaks of heavy US torrenters moving to VPN/seedboxes with exit nodes in EU nations. So, why not target VPN providers? After all, this guy did elude to other VPN services being attacked in similar fashion ...
Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
im having a hard time finding many pics of this, so post whatever you have - /d/ - Hentai/Alternative is 4chans imageboard for alternative hentai images.
Ultimare Horse General Post entire pictures of horse ITT and ask questions and receive questionable ... - /an/ - Animals & Nature is 4chans imageboard for posting pictures of animals, pets, and nature.
u3-u2); : over - >r - r> u< ; \g stack useraddr ( #u -- a_addr ) new a_addr = (Cell *)(up+u); up! ( a_addr -- ) gforth up_store gforth_UP=up=(Address)a_addr; : up ! ; Variable UP [email protected] ( S:... -- a_addr ) gforth sp_fetch a_addr = sp; sp! ( a_addr -- S:... ) gforth sp_store sp = a_addr; [email protected] ( -- a_addr ) gforth rp_fetch a_addr = rp; rp! ( a_addr -- ) gforth rp_store rp = a_addr; \+floating [email protected] ( f:... -- f_addr ) gforth fp_fetch f_addr = fp; fp! ( f_addr -- f:... ) gforth fp_store fp = f_addr; \+ >r ( w -- R:w ) core to_r : (>r) ; : (>r) [email protected] cell+ @ [email protected] ! [email protected] cell+ ! ; r> ( R:w -- w ) core r_from : [email protected] cell+ @ [email protected] @ [email protected] cell+ ! (rdrop) [email protected] ! ; Create (rdrop) ;s A, rdrop ( R:w -- ) gforth : r> r> drop >r ; 2>r ( d -- R:d ) core-ext two_to_r : swap r> swap >r swap >r >r ; 2r> ( R:d -- d ) core-ext two_r_from : r> r> swap r> swap >r swap ; [email protected] ( R:d -- R:d d ) core-ext two_r_fetch : i j ; 2rdrop ( R:d -- ) gforth two_r_drop : r> r> drop r> drop >r ; over ( w1 w2 -- w1 w2 w1 ) core : [email protected] cell+ @ ; ...
u3-u2); : over - >r - r> u< ; \g stack useraddr ( #u -- a_addr ) new a_addr = (Cell *)(up+u); up! ( a_addr -- ) gforth up_store gforth_UP=up=(Address)a_addr; : up ! ; Variable UP [email protected] ( S:... -- a_addr ) gforth sp_fetch a_addr = sp; sp! ( a_addr -- S:... ) gforth sp_store sp = a_addr; [email protected] ( -- a_addr ) gforth rp_fetch a_addr = rp; rp! ( a_addr -- ) gforth rp_store rp = a_addr; \+floating [email protected] ( f:... -- f_addr ) gforth fp_fetch f_addr = fp; fp! ( f_addr -- f:... ) gforth fp_store fp = f_addr; \+ >r ( w -- R:w ) core to_r : (>r) ; : (>r) [email protected] cell+ @ [email protected] ! [email protected] cell+ ! ; r> ( R:w -- w ) core r_from : [email protected] cell+ @ [email protected] @ [email protected] cell+ ! (rdrop) [email protected] ! ; Create (rdrop) ;s A, rdrop ( R:w -- ) gforth : r> r> drop >r ; 2>r ( d -- R:d ) core-ext two_to_r : swap r> swap >r swap >r >r ; 2r> ( R:d -- d ) core-ext two_r_from : r> r> swap r> swap >r swap ; [email protected] ( R:d -- R:d d ) core-ext two_r_fetch : i j ; 2rdrop ( R:d -- ) gforth two_r_drop : r> r> drop r> drop >r ; over ( w1 w2 -- w1 w2 w1 ) core : [email protected] cell+ @ ; ...
Gage R&R in Excel is easy and youll really understand gage R&R maths if you follow the example... or just download the add-in for quick reliable results
Poslat na n j arm du t kood nc a kolonu pandur , chalupu zbourat a d dka zav t na 150 let. Je extr mn spole ensky nebezpe n !!! V echny papou ky na cel m sv t zlikvidovat a p b h napsat do u ebnic.. Ty vynalo en pen ze za to rozhodn stoj !!!. To je opravdu nesl chan .. Bo e a pape i, chra n s p ed t mito hrozn mi narkotiky, men ...
Is your Firefox not allowing you to tab between all form fields or all elements? Or would you rather it didnt allow you to? The solution is to chan
Porsche unveiled the Type 964 version of the 911 in 1988 and it came with several considerable technological upgrades over its predecessor. The list of chan...
There are currently around 160 people working at ProQR, but that wasnt always the case. When Hee Lam Chan joined in 2013, she was only employee number six. As a result, she has seen the company grow and develop.
FIQH HADIS; SOLAT SUNAT ISYRAQ - *SOLAT SUNAT ISYRAQ* Sabda Nabi SAW; مَنْ صَلَّى الغَدَاةَ فِي جَمَاعَةٍ ثُمَّ قَعَدَ يَذْكُرُ اللَّهَ حَتَّى تَطْلُعَ الشَّمْسُ، ثُمَّ صَلَّى رَكْعَتَيْن... ...
Looking for online definition of DigiFab in the Medical Dictionary? DigiFab explanation free. What is DigiFab? Meaning of DigiFab medical term. What does DigiFab mean?
The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- and C19- positions has been developed and applied to the total asymmetric synthesis of steroids 19-hydroxysarmentogenin and trewianin aglycone as well as to the assembly of the panogenin core. and substantially improves the accessibility to the entire class of cardenolides and their derivatives for biological evaluation. and Rabbit Polyclonal to MOV10L1. configuration of the AB ring junction found in steroids 2 3 and 1D (Scheme 4). Thus 4 can be subjected to a 3-4 step Ponatinib sequences to provide diastereomeric scaffolds 16 17 and 18 which are precursors to 2 1 and 3 correspondingly. The C19 hydroxyl-directed hydrogenation of 4 to Ponatinib establish the selective. However based on the trends observed by Knox product 18 (61% yield >20:1 dr 3 steps). Scheme 4 Elaboration of intermediate 4 into precursors of 19-hydroxysarmentogenin (2) panogenin (1D) and trewianin (3)a With these results in hand we ...
Na+, K+-ATPase (NKA) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca2+ oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca2+ signal activates the NF-B subunit p65 and increases the expression of the antiapoptotic factor Bcl-xL. The potential tissue-protective effects of this signal are discussed.. ...
Introduction. Poisoning of livestock by cardiac glycoside-containing plants has the greatest economic impact of all plant-associated poisonings in the Republic of South Africa. Collectively, they are held responsible for 33% of all mortalities from plant poisonings of cattle and 10% of those in small stock (Kellerman, Naudé & Fourie 1996).. Chemically, two major groups of cardiac glycosides, namely the cardenolides and bufadienolides, are recognised (Steyn & Van Heerden 1998). Poisoning of livestock by bufadienolide-containing plants, which surpasses cardenolide-induced poisonings in importance, may either be acute or chronic. Tulp poisoning (induced by various Moraea species) and slangkop poisoning (caused by various Drimia species) induce only acute intoxication, as these species contain non-cumulative bufadienolides (Kellerman et al. 2005). On the other hand, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe), generally referred to as plakkies, may cause either ...
Patient information for DIGIFAB 40MG/VIAL DIGOXIN IMMUNE FAB POWDER FOR SOLUTION FOR INFUSION Including dosage instructions and possible side effects.
2017 BTG International Ltd. All rights reserved. See More, Reach Further, Treat Smarter, Imagine where we can go, and BTG and the BTG roundel logo are trademarks of BTG International Ltd. BTG and the BTG roundel logo are registered trademarks of BTG International Ltd in the US, EU and certain other territories. Bead Block, DC Bead, DC Bead LUMI, LC Bead and LC Bead LUMI are trademarks and/or registered trademarks of Biocompatibles UK Ltd. EKOS and EkoSonic are registered trademarks of EKOS Corporation. GALIL is a trademark of Galil Medical Ltd. PneumRx is a registered trademark of PneumRx, Inc. TheraSphere is a registered trademark of Theragenics Corporation used under license by Biocompatibles UK Ltd. Varithena is a registered trademark of Provensis Ltd. CroFab and DigiFab are registered trademarks of BTG International Inc. Voraxaze is a registered trademark of Protherics Medicines Development Ltd. Lemtrada is a trademark of Genzyme Corporation. Zytiga is a trademark of Johnson & Johnson. ...
2700 rated arena = less point cap than 1700 RBG. This is about as bad as making you do 15 dailies per day every day just to enter a raid dungeon. At the very least you dont have to join groups of mage/lock/priest + one frost dk only tryharding retards that infest 99% of all RBG groups.
2005). At concentrations that have little effect on cell viability, it has been shown to inhibit recombinant HIV-1 reverse transcriptase activity. Research on anti-fungal and anti-parasitic effects of toad skin toxins is still under way. Exhibition of microbicidal effect of the protein could be a result of its ability to form channels or pores within the microbial membrane causing permeation and lysis of the cell. While mechanisms by which bufadienolides exert their bactericidal effect are still debatable the effect of antimicrobial peptides present in these secretions seems to be understood. Since these peptides are generally cationic, they have been proposed to mostly act by disrupting and permeabilizing the target cell membrane (Shai 2002) which thereby prevents the target organism from developing resistance to this defense mechanism, implying a potential therapeutic use of these peptides (Jacob and Zasloff 1994). Gene families coding for such antimicrobial peptides show gene diversification ...
At concentrations found in humans after ingestion of one to two cups of green tea, epicatechin-3-gallate (ECG) modulates Na/K-ATPase conformation and activity. Akin to ouabain, an archetypal Na/K-ATPase ligand of the cardiotonic steroid (CTS) family, ECG also activates protein kinase C epsilon type (PKCε) translocation and increases the force of contraction of the rat heart. This study evaluated whether, like ouabain, ECG also modulates Na/K-ATPase/Src receptor function and triggers pre- and postconditioning against ischemia/reperfusion (I/R) injury. In vitro, ECG activated the purified Na/K-ATPase/Src complex. In Langendorff-perfused rat hearts, submicromolar concentrations of ECG administered either before or after ischemia reduced infarct size by more than 40%, decreased lactate dehydrogenase release, and improved the recovery of cardiac function. ECG protection was blocked by PKCε inhibition and attenuated by mitochondrial KATP channel inhibition. In a unique mammalian cell system with ...
Cardiotonic steroids play a key role in sodium excretion in response to volume expansion. Their effect is mediated through their binding to the Na/K-ATPase..
SWISS-MODEL Repository entry for A0A024RBG1 (NUD4B_HUMAN), Diphosphoinositol polyphosphate phosphohydrolase NUDT4B. Homo sapiens (Human)
Abstract: 目的 研究蟾蜍灵联合奥沙利铂诱导人胃癌细胞株MG C803凋亡及对凋亡因子Bax、Bcl-2的影响.方法 应用MTr法检测不同浓度蟾蜍灵及奥沙利铂单药及联合对胃癌细胞MGC803增殖抑制作用;流式细胞术分析细胞凋亡和周期阻滞;Western印迹法检测Bax、Bcl-2蛋白的表达.结果 (1)蟾蜍灵及奥沙利铂单药均抑制MGC803细胞增殖,呈剂量时间依赖效应,且联合用药的细胞增殖抑制率高于单药组,差... ...
Chan është shfaqur para fansave edhe si këngëtar. Ai promovoi albumin e tij të ri me një performancë live në Tajvan.. Ylli prezantoi të mërkurën albumin I Am Me. Albumi përmban këngë që i kushton familjes, miqve dhe anëtarëve të ekipit të Jackie Chan, Stunt Team.. Ky album përmban këngë që praktikisht, janë rrefime të jetës sime. Janë këngë për njerëzit që kam dashur, për ata që janë larguar dhe që sdo ti shoh më kurrë, këngë të kushtuara tim biri e ndonjë gabimi të tij, këngë që i tregojnë atij se nuk duhet të dorëzohet. Unë i këndoj gjithashtu edhe gruas sime, babait e nënës, fansave të mi, miqve, paqes dhe dashurisë universale,-tha Jakie Chan.. Aktori, i cili është i njohur për rolet në filma, tha se ishte shumë i emocionuar të këndonte disa këngë nga albumi.. ...
Chin Ming Chan Chinese Kitchen - Find, compare & actually reserve the best parking rates near Chin Ming Chan Chinese Kitchen. Book prepaid parking online and save!
Read writing from Chin Chonathorn Chan on Medium. . Every day, Chin Chonathorn Chan and thousands of other voices read, write, and share important stories on Medium.
Wai-Man (Jo) Chan, B.S., Research Technologist Wai-Man (Jo) Chan is a Senior Research Technologist and Lab Manager in the Engle lab. She
ACKyushu writes Say what you like about 4chan; when they want something done, it gets done. Following a call to arms yesterday, the masses inhabiting the anonymous 4chan boards have carried out a huge assault on a pair of anti-piracy enemies. The website of Aiplex Software, the anti-piracy outfit w...
155chan.top is the third chan in the Triforce (180chan.info and 144chan.ws). What makes 155chan special is its new but very popular /hebe/ board where you can open any topic and posts are ...
I thrive in my own chaos (I have three half-completed to-do lists floating around at any given time.) But you know what? It works for me. And ultimately, the best to-do list is really whatever works for you, and your brain. It shouldnt be hard. It shouldnt take you an hour to make. It shouldnt stress you out. For many people, to-do lists are what keep them organized and (mostly) sane. Knowing what you need to do, and when, is a key part of any job, and being able to meet deadlines is crucial in any career. Thats where to-do lists come in. In case you havent found the right to-do list method, we rounded up a few of our best bets-templates included. ...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
So, we hear news of a miraculous treatment for cancer. Disappointingly, the story is an old one which has somehow resurfaced on the blogosphere. When we originally published the story four years ago, it created a frenzy on the internet which took us by surprise. Our story reported a new type of treatment that in animal experiments showed promise of potentially being able to tackle most types of human cancer. We often report developments in cancer research, but nothing had ever attracted such a wave of interest. The drug involved, a simple molecule called dichloro-acetate, or DCA, appeared to work by blocking the unusual, sugar-gobbling mechanism called glycolysis by which most cancer cells generate their energy, and so which potentially marks them out from healthy cells. Exposed to DCA, cancer cells stopped making energy from sugar and resumed making it the way healthy cells do, in chambers called mitochondria. This stopped cancer cells from growing and multiplying, and caused them to wither and ...
So, we hear news of a miraculous treatment for cancer. Disappointingly, the story is an old one which has somehow resurfaced on the blogosphere. When we originally published the story four years ago, it created a frenzy on the internet which took us by surprise. Our story reported a new type of treatment that in animal experiments showed promise of potentially being able to tackle most types of human cancer. We often report developments in cancer research, but nothing had ever attracted such a wave of interest. The drug involved, a simple molecule called dichloro-acetate, or DCA, appeared to work by blocking the unusual, sugar-gobbling mechanism called glycolysis by which most cancer cells generate their energy, and so which potentially marks them out from healthy cells. Exposed to DCA, cancer cells stopped making energy from sugar and resumed making it the way healthy cells do, in chambers called mitochondria. This stopped cancer cells from growing and multiplying, and caused them to wither and ...
Visit Healthgrades for information on Dr. Wilson Chan, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Dr Cathryn Chan, an accredited IVF Clinician, has interests in Reproductive Medicine and Infertility. She practises at Mount Elizabeth Novena and Hougang.
Fingerprint Dive into the research topics where Katherine Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Fifteen months ago Chan and Lam signed up a young, unknown actress named Cecilia Cheung, who has since blossomed as Hong Kongs latest It girl. The trio have collaborated on Twelve Nights.
All contact info about Chan W Ma , 74 from Brooklyn ,New York - address, e-mail, phone, public records, etc at People-Background-Check.com FOR FREE
Alcohol Chan. i dont drink cause i have a slight liver problem whos some of your fav anime characters who drink?. HIKE lg wyi . blt. Alcohol-chan is my spirit animal.
Chan Ho Park talks to reporters about a very special problem he had with his stomach over the last few days. His teammates have zero ability to handle the
DentalPlans detailed profile of Lily Chan, DMD - Dentist in 08701. View plans, sample savings & pricing, patient reviews & practice information.
As the vote to decide who will replace outgoing state Senator Don Perata draws near, the rival campaigns of Wilma Chan and current state Assemblymember...
Buy Bird Reprint edition by Crystal Chan (ISBN: 9781442450912) online at Alibris. Our marketplace offers millions of titles from sellers worldwide.
MISSISSAUGA, ONT.In Russia last month, Patrick Chan discovered a new obstacle to Olympic gold, a threat even greater than foes like Daisuke Takahashi, Yuzuru Hanyu and Evgeni Plushenko: An upset stomach.
Taiwanese artiste Vanness Wu (吳建豪) went to the recording studio and happened to bump into Jackie Chan (成龍) and definitely will not let go of this rare opportunity to take photo together with Jackie. Subsequently on Weibo, Vanness uploaded their photo and wrote: Da Ge (大哥), nice bumping into you at recording studio ...
In case youve never heard of Jaycee Chan, he is the son of actor Jackie Chan. This information is crucial for understanding and caring about the following piece of news. The younger Chan has been detained in Beijing during a...
GROUP securiQ.Watchdog Server: RBGN-HUB ----------------------------------------------------------------------- Your mail item contained viruses or encrypted file! Please check your harddrive! ----------------------------------------------------------------------- Mail-Info From: [email protected]@inet @ [email protected] To: [email protected] CC: Rec.: CN=Erich HAPEL/OU=32250/O=RBGN/C=AT @ RBGN Date: 01.02.2004 11:59:05 Subject: HI ----------------------------------------------------------------------- file contains virus: aul.zip ________________________________________________________________________________ Der Austausch von Nachrichten mit o.a. Absender via e-mail dient ausschliesslich Informationszwecken. Rechtsgeschaeftliche Erklaerungen duerfen ueber dieses Medium nicht ausgetauscht werden. Correspondence with a.m. sender via e-mail is only for information purposes. This medium is not to be used for the exchange of legally-binding communications ...
Wang, C.; Tan, Z.; Niu, B.; Tsang, K. Y.; Tai, A.; Chan, W. C. W.; Lo, R. L. K.; Leung, K. K. H.; Dung, N. W. F.; Itoh, N.; Zhang, Michael Q.; Chan, D.; Cheah, K. S. E. ...
The movie is TEN YEAR which we mentioed a little while ago and also stars Chris Pine, Haylie Duff, Justin Long, Scott Porter, John Krasinski, Anna Faris and her husband Chris Pratt, Brian Geraghty and Kate Mara. It is an ensemble rom-com about a group of friends reuniting 10 years after leaving school. It is scheduled for release in 2011 so best we keep our eye on it and those delightful Tatums now that they have got it off the ground. ...
物理学需要有各种基本量的单位标准体系。我们目前拥有质量,长度和时间的标准定义的SI单位,千克,米,秒。力的标准单位是使用牛顿第二定律作为公理的牛顿(符号N):force =ma,使牛顿为 kg.m/s²。 力的定义决定了SI单位的能量和能量单位是焦耳,或 kg.m²/s² 或牛顿米。 新的相对论力量与力的定义如何:. f=d/dt{ (1/√(1-v²/c²)) mv} -(I). SI 单位的力量单位标准是什么?答:SI 单位没有规定相对论力学的力量标准。从肠道的感觉中,你不可思议地立即作出反应 - 怎么可能?任何人都可以创建一个力学,而且没有一个确定的标准的力量单位。没有一个确定的力量单位,他们如何计算能量的标准能量单位(工作=能量=力x距离)?我不知道 - 你可以尝试自己想一想。牛顿的SI单位来自: f=ma,相对论力来自:f=d/dt{(1/√(1-v²/c²)) mv} - ...
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Film star JACKIE CHAN said that his teams LMP2 victory and overall runner-up spot in the Le Mans 24 Hours this weekend felt exactly like when I got an Oscar. The #38 Jackie Chan DC Racing Oreca led the race overall with just 70 minutes to go, when the recovering works Porsche 919 Hy ... Tags: People and Pop Culture. ...
http://comailab.genomecenter.ucdavis.edu/ Luca Comais Lab] at the [http://genomics.ucdavis.edu/index_html.html UC Davis Genome Center],br ...
http://www.nature.com/neuro/journal/v20/n8/full/nn.4593.html These viruses might be helpful for transducing DRG and the CNS more easily. Ive got some to try out. Ill let you know how it goes. @RPSeal @tberta
http://www.vmcs.ucdavis.edu/Lasso.acgi?-database=Orders.fp3&-response=shop/shop.html&-add Vet Med Central Services shop online],br ...
First off, I did NOT get this from 4Chan, I got it from a topic posted at GameFAQs. I posted it in YTMND form in the hope that I would get a spot in the Up and Coming for an hour or two, and an eventual 3.9, 100 votes rating. I had NO idea it would take off like it did, and frankly, I dont care. Ive read the comments that have been posted about it, and Im glad I was able to touch the hearts of as many people as I did. If you think Im all about posting sentimental crap on YTMND ...
First off, I did NOT get this from 4Chan, I got it from a topic posted at GameFAQs. I posted it in YTMND form in the hope that I would get a spot in the Up and Coming for an hour or two, and an eventual 3.9, 100 votes rating. I had NO idea it would take off like it did, and frankly, I dont care. Ive read the comments that have been posted about it, and Im glad I was able to touch the hearts of as many people as I did. If you think Im all about posting sentimental crap on YTMND ...
The most common natural products containing a 2-pyrone are the bufanolides and kavalactones. Oxovitisin A, a pyranoanthocyanin ...
... is a cardiotoxic bufanolide steroid secreted by the Argentine toad Bufo arenarum. It has effects similar to ...
... is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. It has similar effects to ...
... is a cardiotoxic bufanolide steroid, cardiac glycoside analogue, secreted by a number of toad species. Bufotalin can ...
... and the saturated equivalent is bufanolide. According to MeSH, bufadienolides and bufanolides are classified as follows: ... Polycyclic compounds Steroids Cardanolides Cardiac glycosides Bufanolides (includes bufenolides, bufadienolides, ...
It is of the bufanolide type and can be obtained from plants of the genus Scilla and in Drimia maritima (Scilla maritima). The ...
However, the leaves contain a bufanolide called cotyledontoxin, which is toxic to sheep, goats, horses, cattle, poultry, and ...
The molecular formula C24H32O6 (molar mass: 416.50 g/mol, exact mass: 416.219889) may refer to: Arenobufagin, a bufanolide ...
... is a C24 steroid and, indirectly, a parent structure of bufadienolide. Its derivatives was found in Bufo and Scilla ... a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K + currents expressed in HEK293 cells". ...
Bufanolide is a C24 steroid and, indirectly, a parent structure of bufadienolide. Its derivatives was found in Bufo and Scilla ... a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K + currents expressed in HEK293 cells". ...
... bufanolide explanation free. What is bufanolide? Meaning of bufanolide medical term. What does bufanolide mean? ... Looking for online definition of bufanolide in the Medical Dictionary? ... Bufanolide , definition of bufanolide by Medical dictionary https://medical-dictionary.thefreedictionary.com/bufanolide ... bufanolide. Also found in: Wikipedia. bu·fan·o·lide. (bū-fanō-līd), The fundamental steroid lactone of several vegetable (for ...
Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha from Waterstones today! Click and Collect from your local ... Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides: Volume 3 (Paperback). Viqar Uddin Ahmad ( ...
Spectroscopic data of steroid glycosides spirostanes bufanolides cardenolides. Ideal for general use and large samples. ...
bufanolide. (redirected from bufatrienolide) bu·fan·o·lide. (bū-fanō-līd), The fundamental steroid lactone of several ...
本网站文字内容采用知识共享署名-相同方式共
esteroide (es); Стероидтар (kk-kz); Steroid (ms); ستەروىيدتار (kk-cn); Стероид (bg); Steroid (ro); 甾體 (zh-hk); Steroid (sk); Esteroïde (oc); 甾體 (zh-hant); 甾体 (zh-cn); 스테로이드 (ko); Стероидтар (kk); steroido (eo); steroidy (cs); Steroidogeneza (bs); স্টেরয়েড (bn); stéroïde (fr); Steroid (jv); steroid (hr); סטערויד (yi); Steroid (vi); ستەروىيدتار (kk-arab); Steroïdtar (kk-latn); Steroïed (af); Стероиди (sr); 甾体 (zh-sg); Стероидтар (kk-cyrl); steroid (nn); steroid (nb); Stéroid (su); steroid (en); ستيرويد (ar); 類固醇 (yue); Steroïdtar (kk-tr); Esteroide (eu); Esteroide (ast); esteroide (ca); Steroid (cy); Stéaróideach (ga); ստերոիդներ (hy); 甾體 (zh); steroid (da); ステロイド (ja); סטרואיד (he); स्टेरॉयड (hi); Steroidi (fi); steroide (it); Estewoyid (ht); Стэроіды (be-tarask); Στεροειδές (el); steroīds ...
Cardenolides and bufanolides --. Ecdysteroids --. Estrogens --. Pregnanes and corticoids --. Sterols --. Vitamin D.. Series ... Cardenolides and bufanolides -- Ecdysteroids -- Estrogens -- Pregnanes and corticoids -- Sterols -- Vitamin D."@en ;. schema: ...
Bufanolides and derivatives [ST0113]. Brassinolides and derivatives [ST0114]. Solanidines and alkaloid derivatives [ST0115] ...
Vol.3: Spirostanes, Bufanolides, Cardenolides. - 2007. - P.1403-2088. - ISBN: 0387311610 (v.3). - ISBN: 0387343482 (set). 032 ...
The most common natural products containing a 2-pyrone are the bufanolides and kavalactones. Oxovitisin A, a pyranoanthocyanin ...
Cardanolide and bufanolide derivatives, found in many plants and in the skin of toads, cause vomiting, visual disturbances, and ... except in the cardanolides and bufanolides; compounds of these types characteristically possess the 5β,14β configurations, ...
keywords = "Bufanolides, Heart failure, Na(+)-K(+)-exchanging ATPase, Natriuretic peptides, Ouabain, Steroids", ...
Bufanolides/chemistry/metabolism/pharmacology*/toxicity. *Neoplasms/metabolism*. *Sodium-Potassium-Exchanging ATPase/ ...
It is of the bufanolide type and can be obtained from plants of the genus Scilla, notably Scilla maritima. ...
Lanen, J. B. J. M., Lovas, R. G., Kruppa, A., Blok, H. P., Van Den Brand, J. F. J., Ent, R., Jans, E., Kramer, G. J., Lapiks, L., Quint, E. N. M., Van Der Steenhoven, G., Tiemeijer, P. C. & De Witt Huberts, P. K. A., 1989, In : Physical Review Letters. 63, 26, p. 2793-2796 4 p.. Research output: Contribution to journal › Article ...
Levin, P. S., Essington, T. E., Marshall, K. N., Koehn, L. E., Anderson, L. G., Bundy, A., Carothers, C., Coleman, F., Gerber, L., Grabowski, J. H., Houde, E., Jensen, O. P., Möllmann, C., Rose, K., Sanchirico, J. N. & Smith, A. D. M., Jan 1 2018, (Accepted/In press) In : Marine Policy.. Research output: Contribution to journal › Article ...
TY - JOUR. T1 - Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. AU - Dong, Yinhui. AU - Yin, Shutao. AU - Li, Jinghua. AU - Jiang, Cheng. AU - Ye, Min. AU - Hu, Hongbo. N1 - Funding Information: Acknowledgments This work was supported by grants from Chinese Universities Scientific Fund (2009-2-11), National Natural Science Foundation of China (NSFC, 31071533, 30972172). We thank Prof. Carine Michiels for generously providing the pCMV-HA-Mcl-1 plasmid and Prof. Junxuan Lu for providing valuable comments and writing assistance. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/4. Y1 - 2011/4. N2 - The death receptor ligand TRAIL is considered a promising candidate for cancer therapy because of its preferential toxicity to malignant cells. However its efficacy has been challenged by a number of resistance mechanisms. Therefore, agents that can overcome the resistance to enhance therapeutic efficacy ...
Fingerprint Fingerprint is based on mining the text of the experts scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher. ...
Drake, D., Morrow, C. D., Kinlaw, K., De Bonis, M., Zangrillo, A., Sade, R. M., Blitzer, D., Carpenter, A. J., Ceppa, D. K. P., Chen, E. P., Cohen, R. G., DAmico, T. A., Drake, D. H., Entwistle, J. W., Fedak, P. W., Fenton, K. N., Loebe, M., Mayer, J. E., McKneally, M. F., Merrill, W. H. & 14 others, Millikan, S. J., Moffatt-Bruce, S. D., Murthy, S. C., Naunheim, K. S., Orringer, M. B., Pickens, A., Ray, S., Romano, J. C., Starnes, S. L., Swain, J. A., Tweddell, J. S., Whyte, R. I., Wood, D. D. & Zwischenberger, J. B., Aug 2020, In : Journal of Thoracic and Cardiovascular Surgery. 160, 2, p. 456-459 4 p.. Research output: Contribution to journal › Editorial › peer-review ...
Fingerprint Dive into the research topics where Timothy Corson is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Bufanolides/administration & dosage*. *Bufanolides/pharmacology. *Carcinoma, Hepatocellular/drug therapy*. *Carcinoma, ...
... , Pharmacology , Carcinoma, Non-Small-Cell Lung , Metabolism , Pathology , Cell Line, Tumor , Cell Proliferation , ... Apoptosis , Bufanolides , Pharmacology , Caspase 9 , Metabolism , Cell Survival , Colorectal Neoplasms , Pathology , Humans , ... Animals , Bufanolides , Pharmacology , Calcium , Metabolism , Cell Communication , Cell Proliferation , Cells, Cultured , Gap ... Animals , Bufanolides , Chemistry , Bufo bufo , Medicine, Chinese Traditional , Molecular Structure , Venoms , Chemistry ...
Bufanolides/chemistry, Isoelectric Point, Cardiac Glycosides/toxicity, Evolution, Molecular", ...
Members contain hellebrin (BUFANOLIDES). The extract is the basis of Boicil preparation used to treat rheumatism. The common ... Members contain hellebrin (BUFANOLIDES). The extract is the basis of Boicil preparation used to treat rheumatism. The common ...
v. 2. Stigmastanes, furostanes, spirtostanes-- v. 3. Spirostanes, bufanolides, cardenolides-- v. 4. Cardenolides and pregnanes ... bufanolides, cardenolides-- v. 4. Cardenolides and pregnanes -- v. 5. Pregnanes, androstanes, and miscellaneous -- v. 6. ... bufanolides, cardenolides-- v. 4. Cardenolides and pregnanes -- v. 5. Pregnanes, androstanes, and miscellaneous -- v. 6. ...
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans.. ...
Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Bufanolides / Bufo bufo / Chemistry / Injections / ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Bufanolides / Bufo bufo / Chemistry / Injections / ...
5β,14β- bufanolide. C24H38O2. 3β,14-˫?ǻ?-5β,14β-?? -20(22)-ϩ?? ë ػ ??Ԫ ...
  • Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. (abmole.com)
  • Bufanolide is a C24 steroid and, indirectly, a parent structure of bufadienolide. (wikipedia.org)