Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.IllinoisChicagoGrateful Med: A microcomputer-based software package providing a user-friendly interface to the MEDLARS system of the National Library of Medicine.Dermatoglyphics: The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.MiningBiometric Identification: A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.Random Amplified Polymorphic DNA Technique: Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.Bufanolides: Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Benzenesulfonates: Organic salts and esters of benzenesulfonic acid.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Amygdalin: A cyanogenic glycoside found in the seeds of Rosaceae.Quackery: The fraudulent misrepresentation of the diagnosis and treatment of disease.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Pragmatic Clinical Trials as Topic: Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Prunus: A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of edible fruits such as apricot, plum, peach, cherry, and almond.Nuts: Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Carbohydrate Metabolism: Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. (1/125)

Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various lines of human tumor cells, such as leukemia HL60 and U937 cells, by altering the expression of apoptosis-related genes, for example, bcl-2 and c-myc. In this study, we characterized a gene that is involved in bufalin-induced apoptosis by the differential display (DD) technique. The partial nucleotide sequence of one of the differentially expressed clones obtained after treatment with bufalin was identical to that of the human gene for Tiam1. When U937 cells were treated with 10(-7) M bufalin, expression of both Tiam1 mRNA and the protein was induced 1 h after the start of the treatment. The increase of Tiam1 mRNA was transient but the level of Tiam1 protein continued to increase at least for 6 h. In addition, the activities of Rac1 and p21-activated kinase (PAK) were also stimulated by bufalin treatment. To evaluate the role of Tiam1 in the apoptotic process, we examined the effects of the expression of sense and antisense RNA for Tiam1 in U937 cells. Apoptosis was strongly induced by bufalin in cells that expressed sense RNA for Tiam1 as compared to apoptosis in control cells treated with bufalin only. Cells expressing antisense RNA for Tiaml were significantly more resistant than the control bufalin-treated cells to induction of DNA fragmentation in response to bufalin. Moreover, sense transformants had elevated activities of PAK and c-Jun NH2-terminal kinase (JNK). These results suggest that Tiaml might play a critical role in bufalin-induced apoptosis through the activation of Rac1, PAK, and JNK pathway.  (+info)

Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. (2/125)

To identify genes that are differentially expressed by Na+, K+-ATPase inhibitors, we used the differential display technique to compare mRNA expression patterns in rat lens. Lenses were treated with 10 microM ouabain, bufalin, or 19-norbufalin derivative for 24 h and were compared with control lenses. Differential display analysis revealed that one of the down-regulated genes was 14-3-3 theta. Down-regulation was confirmed by Northern blot and by reverse transcription-polymerase chain reaction analysis. Reverse transcription-polymerase chain reaction of additional 14-3-3 isoforms revealed that the eta and gamma isoforms of 14-3-3 are also down-regulated by ouabain, bufalin, and 19-norbufalin derivative, whereas the zeta isoform is down-regulated only by bufalin. Down-regulation of the 14-3-3 isoforms occurred without a significant change in gamma-crystallin gene expression. These results demonstrate that one of the consequences of Na+, K+-ATPase inhibition by exogenous or endogenous inhibitors is the down-regulation of mRNA transcripts encoding several isoforms of 14-3-3. Because the 14-3-3 proteins are multifunctional regulatory proteins, the reduction in the abundance of various isoforms will have profound effects on cell function.  (+info)

Induction of apoptosis by bufalin in human tumor cells is associated with a change of intracellular concentration of Na+ ions. (3/125)

In an attempt to characterize the mechanisms that are operative at the early stages of the induction of apoptosis by bufalin, a component of the traditional Chinese medicine chan'su, we examined the effects of bufalin on plasma membrane potential, as determined by monitoring the uptake by cells of rhodamine 123. Bufalin induced apoptosis in human monocytic leukemia THP-1 cells, in human lymphoblastic leukemia MOLT-3 cells, and in human colon adenocarcinoma COLO320DM cells but not in normal human leukocytes, for example, polymorphonuclear cells and lymphocytes, and not in murine leukemia P388D1 and M1 cells. Treatment for 3 h with bufalin at 10(-6) M caused a decrease in the plasma membrane potential in several lines of human tumor cells but not in murine leukemia cells. No changes in mitochondrial membrane potential, as monitored with the fluorescent dye JC-1, and no release of cytochrome c were observed within at least 6 h after the start of treatment with bufalin. Moreover, overexpression of bcl-2 in human leukemia HL60 cells that had been transfected with cDNA for bcl-2 prevented bufalin-induced apoptosis but had no significant effect on the change in plasma membrane potential induced by bufalin. Since bufalin specifically inhibits the Na+,K(+)-ATPase of human but not murine tumor cells, and since this inhibition leads to a change in intracellular concentration of Na+ ions, our findings suggest that bufalin induces apoptosis in human tumor cells selectively via inhibition of the Na+,K(+)-ATPase, which acts upstream of the bcl-2 protein.  (+info)

ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. (4/125)

Treatment of human leukemia THP-1 cells with bufalin, a specific inhibitor of Na(+)-K(+)-ATPase, sequentially induces c-fos and inflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) gene expressions before the appearance of mature phenotypes of monocytic cells. In this study we examined the signal transduction leading to bufalin-induced gene expressions. Bufalin selectively activated extracellular signal-regulated kinase (ERK), compared with other mitogen-activated protein (MAP) kinase family members. Pretreatment of THP-1 cells with PD-98059, an inhibitor of the ERK-kinase cascade, abolished bufalin-induced c-fos and IL-1 beta gene expressions, indicating that the ERK-kinase cascade mediates the induction of inflammatory cytokines by bufalin. Inhibition of the Na(+)/Ca(2+) exchanger by KB-R7943 and of protein kinase C (PKC) by Ro-31-8220 suppressed ERK activation and gene expressions of c-fos and IL-1 beta. These findings suggest that Na(+)-K(+)-ATPase inhibition by bufalin induces calcium influx and thereby activates PKC and ERK. In cells treated with an inhibitor of p38 MAP kinases, SB-203580, bufalin-mediated ERK activation became persistent and the induction of IL-1 beta and TNF-alpha expressions was significantly augmented. These results suggest that cross talk in bufalin-mediated ERK activation is negatively regulated by endogenous p38 MAP kinase activations.  (+info)

New insecticidal bufadienolide, bryophyllin C, from Kalanchoe pinnata. (5/125)

Two insecticidal bufadienolides (1 and 2) were isolated from a methanol extract of the leaves of Kalanchoe pinnata by bioassay-guided fractionation. Compound 1 was identified as known bryophyllin A (bryotoxin C). The structure of new bufadienolide 2, named bryophyllin C, was determined by spectroscopic methods and the chemical transformation of 1. Compounds 1 and 2 showed strong insecticidal activity against third instar larvae of the silkworm (Bombyx mori), their LD50 values being evaluated as 3 and 5 microg/g of diet, respectively.  (+info)

Positive and negative interference of the Chinese medicine Chan Su in serum digoxin measurement. Elimination of interference by using a monoclonal chemiluminescent digoxin assay or monitoring free digoxin concentration. (6/125)

An over-the-counter Chinese medicine, Chan Su, is used as a cardiotonic agent. We demonstrated significant digoxin-like immunoreactivity in various organic and aqueous extracts of Chan Su. For example, when a 20-microL aliquot of an aqueous extract of Chan Su powder (1 mg/mL) was added to a 2-mL aliquot of a drug-free serum, the observed digoxin-like immunoreactivity was 2.76 ng/mL (3.53 nmol/L) digoxin equivalent using the fluorescence polarization immunoassay (FPIA). The magnitude of interference was much lower (0.94 ng/mL [1.20 nmol/L]) with the microparticle enzyme immunoassay (MEIA), and no interference was observed with the chemiluminescent assay (CLIA). We also observed a significant positive interference of the extract with the serum digoxin measurement using FPIA. In contrast, we observed a negative interference (falsely lowered digoxin concentration) of the extract in the serum digoxin measurement with the MEIA. The extract had no effect on the serum digoxin measurement with the CLIA. By taking advantage of the high protein binding of Chan Su and only 25% protein binding of digoxin, we further demonstrated that positive interference of Chan Su in the FPIA and negative interference of Chan Su in the MEIA of digoxin could be eliminated by monitoring the free digoxin concentration.  (+info)

Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that Is independent of cholesterol side-chain cleavage. (7/125)

An increasing body of evidence suggests that an endogenous mammalian bufadienolide (BD) may be involved in the regulation of Na(+),K(+)-ATPase activity and the pathogenesis of arterial hypertension. We developed a purification scheme for marinobufagenin (MBG), an amphibian cardiotonic BD, and applied it to purify and characterize material in human plasma, culture medium conditioned by Y-1 adrenocortical cells, and rat adrenal tissue. MBG immunoreactivity purified from plasma and measured by ELISA showed important similarities (chromatography and antibody cross-reactivity) to material secreted into cell culture medium by Y-1 cells. This observation indicates that circulating mammalian BD may have an adrenocortical origin. Release of mammalian BD from adrenocortical cells grown in the absence of exogenous cholesterol was reduced by treatment of cultures with mevastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Supplementation of the serum and cholesterol-free cell culture medium with the LDL fraction of human plasma increased the production of MBG material in the presence of mevastatin, supporting its origin from cholesterol. We used Y-1 cell lines transfected with genes shown to inhibit steroidogenesis through cholesterol side-chain cleavage (Y-1/DAX and Y-1/RIAB) to investigate the dependence of MBG biosynthesis on side-chain cleavage. Our results indicate that the mammalian BD is synthesized in the adrenal cortex from cholesterol and shares important similarities with the amphibian BD MBG, that its biosynthesis is independent of transfer of cholesterol to the side-chain cleavage enzyme complex mediated by steroidogenic acute regulatory protein, and that neither cAMP nor protein kinase A appears to be a critical component of the pathway controlling its biosynthesis.  (+info)

Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens. (8/125)

Na+,K+-ATPase activity in the epithelial layer is fundamental to the maintenance of ionic concentration gradients and transparency of the lens. Recently we have identified endogenous digitalislike compounds (DLC), 19-norbufalin and its peptide derivatives, in human cataractous lenses (Lichtstein et al. Eur J Biochem 216: 261-268, 1993). Lenses were treated with 10 nM ouabain, bufalin or 19-norbufalin derivative for 24 h and were compared to control lenses. Differential display analysis revealed that one of the down-regulated genes was 14-3-3 theta. Down-regulation was confirmed by Northern blot and by RT-PCR analysis. RT-PCR of additional 14-3-3 isoforms revealed that the eta and gamma isoforms of 14-3-3 are also down-regulated by ouabain, bufalin and 19-norbufalin derivative, whereas the zeta isoform is down-regulated only by bufalin. These results demonstrate that one of the consequences of Na+,K+-ATPase inhibition by exogenous or endogenous inhibitors is the down-regulation of mRNA transcripts encoding several isoforms of 14-3-3. Since the 14-3-3 proteins are multifunctional regulatory proteins, the reduction in the abundance of various isoforms will have profound effects on cell function. Furthermore, These results, together with the demonstration of digitalislike compounds in the normal lens, and their increased level in human cataractous lenses, strongly suggests their involvement in the molecular mechanisms responsible for cataract formation.  (+info)

*2-Pyrone

The most common natural products containing a 2-pyrone are the bufanolides and kavalactones. Oxovitisin A, a pyranoanthocyanin ...

*Arenobufagin

... is a cardiotoxic bufanolide steroid secreted by the Argentine toad Bufo arenarum. It has effects similar to ...

*Cinobufagin

... is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. It has similar effects to ...

*Bufotalin

... is a cardiotoxic bufanolide steroid, cardiac glycoside analogue, secreted by a number of toad species. Bufotalin can ...

*Bufadienolide

... and the saturated equivalent is bufanolide. According to MeSH, bufadienolides and bufanolides are classified as follows: ... Polycyclic compounds Steroids Cardanolides Cardiac glycosides Bufanolides (includes bufenolides, bufadienolides, ...

*Proscillaridin

It is of the bufanolide type and can be obtained from plants of the genus Scilla and in Drimia maritima (Scilla maritima). The ...

*Cotyledon orbiculata

However, the leaves contain a bufanolide called cotyledontoxin, which is toxic to sheep, goats, horses, cattle, poultry, and ...

*C24H32O6

The molecular formula C24H32O6 (molar mass: 416.50 g/mol, exact mass: 416.219889) may refer to: Arenobufagin, a bufanolide ...
Bufadienolide is a chemical compound with steroid structure. Its derivatives are collectively known as bufadienolides, including many in the form of bufadienolide glycosides (bufadienolides that contain structural groups derived from sugars). These are a type of cardiac glycoside, the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an atrioventricular block, bradycardia (slow heartbeat), ventricular tachycardia (a type of rapid heartbeat), and possibly lethal cardiac arrest. The term derives from the toad genus Bufo that contains bufadienolide glycosides, the suffix -adien- that refers to the two double bonds in the lactone ring, and the ending -olide that denotes the lactone structure. Consequently, related structures with only one double bond are called bufenolides,[citation needed] and the saturated equivalent is bufanolide. According to MeSH, bufadienolides and bufanolides are classified as follows: Polycyclic compounds ...
Abstract Spironolactone has been noted to attenuate cardiac fibrosis. We have observed that the cardiotonic steroid marinobufagenin plays an important role in the diastolic dysfunc..
Preeclampsia (PE) complicates from 5 to 10% of pregnancies and it is a number one cause of maternal and fetal morbidity and mortality worldwide. Nevertheless, a specific and highly effective therapy of this disorder does not exist. As illustrated by therapeutic efficacy of anti-digoxin antibody (DIGIBIND) in preeclampsia, endogenous digitalis-like sodium pump ligands play an important role in the pathogenesis of this syndrome. Previously, we demonstrated that levels of endogenous bufadienolide Na/KATPase inhibitors are elevated in patients with PE, and that antibody to marinobufagenin lower blood pressure in rats with pregnancy-induced hypertension and ex vivo reverse inhibition of the Na/K-ATPase from erythrocytes from patients with PE. Most recently, we developed three anti-MBG monoclonal antibodies which in lower blood pressure in several rat experimental models.. We are proposing a pilot proof-of concept study aimed to demonstrate that MBG is target for DIGIBIND in preeclampsia. If ...
Glentham Life Sciences is a supplier of GP1238 - Resibufogenin (465-39-4). Find catalogue prices, chemical data, technical specifications and MSDS documents.
This study will investigate the effects of anti-digoxin polyclonal antibody [DIGIBIND] on marinobufagenin levels in pregnant women with preeclampsia.
Sigma-Aldrich offers abstracts and full-text articles by [Xiao-Liang Wang, Guang-Hou Zhao, Jin Zhang, Qi-Yun Shi, Wei-Xiao Guo, Xiu-Li Tian, Jia-Zhang Qiu, Li-Zi Yin, Xu-Ming Deng, Yu Song].
Despite this reclassification, abnormalities of cardiac structure or function are still frequent when CMR is performed in ESRD. In a pivotal study of 134 patients who had been undergoing renal replacement therapy for an average duration of 12 months, CMR with gadolinium (Gd) contrast agents was performed on the post-dialysis day or at dry weight for peritoneal dialysis (9). The most frequent abnormality detected was LVH (72%), with comparatively low rates of LV dilation (11%) and LV systolic dysfunction (8%). The importance of an accurate, volume-independent measure of cardiac mass is paramount, given that LVH is a strong independent risk factor for mortality, cardiac arrhythmia, and heart failure in patients undergoing dialysis (10). However, the categorization of patients as having LVH is not a biological dichotomy; LV mass is a continuous variable with a graded relationship with cardiovascular risk. This is reflected by improved cardiovascular outcomes with LV mass regression when both LV ...
So usually you have 2-3 groups, group1 LM, group2, BS, group3 farm, or group 1 defend flag, group 2 get flag, something along those lines. My thesis is that, a RBG team that consists of 2 or 3x 5 man arena teams, could beat any RBG team without players being so accustomed to another. So in example: If 5 people defend farm, and 5 who all are in the same arena team attack, the attackers will win the fight. Has anyone tested this to a certain extend?
Ive been deliberately waiting to weigh in on this discussion - , however, my thoughts are as follows: , , 1.) Marking a module as deprecated is *not* the same thing as moving , it out of the code base. It simply means that there is no maintainer, , and something better exists in the code base to move to. , , 2.) Code areas marked as deprecated usually dont have a fixed sunset , point where the code is actually removed, which is what I think Dan , might have been pushing for. , , 3.) In order to move forward with any sort of deprecation process, in , my mind we need to ensure that chan_pjsip has considerable, if not , complete, feature parity with chan_sip. , , 4.) I also feel like the plan to make chan_pjsip capable of reading , sip.conf and perhaps even the chan_sip realtime tables a necessary , prerequisite for code removal, and perhaps even marking of the module , as deprecated. , , 5.) I think talk of pulling chan_sip completely out right now is , premature and probably freaking a lot of ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
AFTER a frantic Friday night of discussion, Bafana Bafana won their battle against Kaizer Chiefs and Wits and both PSL clubs have agreed to release their combined nine players for this months African Nations Championship (Chan), which begins in Cape Town on Saturday...
Fingerprint Dive into the research topics where Shih-Huang Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Fingerprint Dive into the research topics where Andrew Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Super Milk Chan Flash is currently unavailable to stream on-demand, but may be available on Hulu with Live TV depending on regional availability. Try Live TV for free.
|Currently Online| US - Sargeras - Alliance/Area 52 - Horde - Is recruiting players for 11 raid teams, 3 RBG teams, and social/casual players of all...
After all. In a recent report bittorrent traffic is down in the US, while going up in Europe (yet overall bandwidth usage in the US has stayed relatively the same). That bespeaks of heavy US torrenters moving to VPN/seedboxes with exit nodes in EU nations. So, why not target VPN providers? After all, this guy did elude to other VPN services being attacked in similar fashion ...
Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
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Gage R&R in Excel is easy and youll really understand gage R&R maths if you follow the example... or just download the add-in for quick reliable results
Poslat na n j arm du t kood nc a kolonu pandur , chalupu zbourat a d dka zav t na 150 let. Je extr mn spole ensky nebezpe n !!! V echny papou ky na cel m sv t zlikvidovat a p b h napsat do u ebnic.. Ty vynalo en pen ze za to rozhodn stoj !!!. To je opravdu nesl chan .. Bo e a pape i, chra n s p ed t mito hrozn mi narkotiky, men ...
Is your Firefox not allowing you to tab between all form fields or all elements? Or would you rather it didnt allow you to? The solution is to chan
FIQH HADIS; SOLAT SUNAT ISYRAQ - *SOLAT SUNAT ISYRAQ* Sabda Nabi SAW; مَنْ صَلَّى الغَدَاةَ فِي جَمَاعَةٍ ثُمَّ قَعَدَ يَذْكُرُ اللَّهَ حَتَّى تَطْلُعَ الشَّمْسُ، ثُمَّ صَلَّى رَكْعَتَيْن... ...
Looking for online definition of DigiFab in the Medical Dictionary? DigiFab explanation free. What is DigiFab? Meaning of DigiFab medical term. What does DigiFab mean?
Na+, K+-ATPase (NKA) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca2+ oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca2+ signal activates the NF-B subunit p65 and increases the expression of the antiapoptotic factor Bcl-xL. The potential tissue-protective effects of this signal are discussed.. ...
Introduction. Poisoning of livestock by cardiac glycoside-containing plants has the greatest economic impact of all plant-associated poisonings in the Republic of South Africa. Collectively, they are held responsible for 33% of all mortalities from plant poisonings of cattle and 10% of those in small stock (Kellerman, Naudé & Fourie 1996).. Chemically, two major groups of cardiac glycosides, namely the cardenolides and bufadienolides, are recognised (Steyn & Van Heerden 1998). Poisoning of livestock by bufadienolide-containing plants, which surpasses cardenolide-induced poisonings in importance, may either be acute or chronic. Tulp poisoning (induced by various Moraea species) and slangkop poisoning (caused by various Drimia species) induce only acute intoxication, as these species contain non-cumulative bufadienolides (Kellerman et al. 2005). On the other hand, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe), generally referred to as plakkies, may cause either ...
Patient information for DIGIFAB 40MG/VIAL DIGOXIN IMMUNE FAB POWDER FOR SOLUTION FOR INFUSION Including dosage instructions and possible side effects.
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2700 rated arena = less point cap than 1700 RBG. This is about as bad as making you do 15 dailies per day every day just to enter a raid dungeon. At the very least you dont have to join groups of mage/lock/priest + one frost dk only tryharding retards that infest 99% of all RBG groups.
2005). At concentrations that have little effect on cell viability, it has been shown to inhibit recombinant HIV-1 reverse transcriptase activity. Research on anti-fungal and anti-parasitic effects of toad skin toxins is still under way. Exhibition of microbicidal effect of the protein could be a result of its ability to form channels or pores within the microbial membrane causing permeation and lysis of the cell. While mechanisms by which bufadienolides exert their bactericidal effect are still debatable the effect of antimicrobial peptides present in these secretions seems to be understood. Since these peptides are generally cationic, they have been proposed to mostly act by disrupting and permeabilizing the target cell membrane (Shai 2002) which thereby prevents the target organism from developing resistance to this defense mechanism, implying a potential therapeutic use of these peptides (Jacob and Zasloff 1994). Gene families coding for such antimicrobial peptides show gene diversification ...
At concentrations found in humans after ingestion of one to two cups of green tea, epicatechin-3-gallate (ECG) modulates Na/K-ATPase conformation and activity. Akin to ouabain, an archetypal Na/K-ATPase ligand of the cardiotonic steroid (CTS) family, ECG also activates protein kinase C epsilon type (PKCε) translocation and increases the force of contraction of the rat heart. This study evaluated whether, like ouabain, ECG also modulates Na/K-ATPase/Src receptor function and triggers pre- and postconditioning against ischemia/reperfusion (I/R) injury. In vitro, ECG activated the purified Na/K-ATPase/Src complex. In Langendorff-perfused rat hearts, submicromolar concentrations of ECG administered either before or after ischemia reduced infarct size by more than 40%, decreased lactate dehydrogenase release, and improved the recovery of cardiac function. ECG protection was blocked by PKCε inhibition and attenuated by mitochondrial KATP channel inhibition. In a unique mammalian cell system with ...
Cardiotonic steroids play a key role in sodium excretion in response to volume expansion. Their effect is mediated through their binding to the Na/K-ATPase..
Abstract: 目的 研究蟾蜍灵联合奥沙利铂诱导人胃癌细胞株MG C803凋亡及对凋亡因子Bax、Bcl-2的影响.方法 应用MTr法检测不同浓度蟾蜍灵及奥沙利铂单药及联合对胃癌细胞MGC803增殖抑制作用;流式细胞术分析细胞凋亡和周期阻滞;Western印迹法检测Bax、Bcl-2蛋白的表达.结果 (1)蟾蜍灵及奥沙利铂单药均抑制MGC803细胞增殖,呈剂量时间依赖效应,且联合用药的细胞增殖抑制率高于单药组,差... ...
Chan është shfaqur para fansave edhe si këngëtar. Ai promovoi albumin e tij të ri me një performancë live në Tajvan.. Ylli prezantoi të mërkurën albumin "I Am Me". Albumi përmban këngë që i kushton familjes, miqve dhe anëtarëve të ekipit të Jackie Chan, Stunt Team.. "Ky album përmban këngë që praktikisht, janë rrefime të jetës sime. Janë këngë për njerëzit që kam dashur, për ata që janë larguar dhe që sdo ti shoh më kurrë, këngë të kushtuara tim biri e ndonjë gabimi të tij, këngë që i tregojnë atij se nuk duhet të dorëzohet. Unë i këndoj gjithashtu edhe gruas sime, babait e nënës, fansave të mi, miqve, paqes dhe dashurisë universale,"-tha Jakie Chan.. Aktori, i cili është i njohur për rolet në filma, tha se ishte shumë i emocionuar të këndonte disa këngë nga albumi.. ...
Chin Ming Chan Chinese Kitchen - Find, compare & actually reserve the best parking rates near Chin Ming Chan Chinese Kitchen. Book prepaid parking online and save!
Read writing from Chin Chonathorn Chan on Medium. . Every day, Chin Chonathorn Chan and thousands of other voices read, write, and share important stories on Medium.
Wai-Man (Jo) Chan, B.S., Research Technologist Wai-Man (Jo) Chan is a Senior Research Technologist and Lab Manager in the Engle lab. She
ACKyushu writes Say what you like about 4chan; when they want something done, it gets done. Following a call to arms yesterday, the masses inhabiting the anonymous 4chan boards have carried out a huge assault on a pair of anti-piracy enemies. The website of Aiplex Software, the anti-piracy outfit w...
155chan.top is the third chan in the Triforce (180chan.info and 144chan.ws). What makes 155chan special is its new but very popular /hebe/ board where you can open any topic and posts are ...
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So, we hear news of a miraculous treatment for cancer. Disappointingly, the story is an old one which has somehow resurfaced on the blogosphere. When we originally published the story four years ago, it created a frenzy on the internet which took us by surprise. Our story reported a new type of treatment that in animal experiments showed promise of potentially being able to tackle most types of human cancer. We often report developments in cancer research, but nothing had ever attracted such a wave of interest. The drug involved, a simple molecule called dichloro-acetate, or DCA, appeared to work by blocking the unusual, sugar-gobbling mechanism called glycolysis by which most cancer cells generate their energy, and so which potentially marks them out from healthy cells. Exposed to DCA, cancer cells stopped making energy from sugar and resumed making it the way healthy cells do, in chambers called mitochondria. This stopped cancer cells from growing and multiplying, and caused them to wither and ...
So, we hear news of a miraculous treatment for cancer. Disappointingly, the story is an old one which has somehow resurfaced on the blogosphere. When we originally published the story four years ago, it created a frenzy on the internet which took us by surprise. Our story reported a new type of treatment that in animal experiments showed promise of potentially being able to tackle most types of human cancer. We often report developments in cancer research, but nothing had ever attracted such a wave of interest. The drug involved, a simple molecule called dichloro-acetate, or DCA, appeared to work by blocking the unusual, sugar-gobbling mechanism called glycolysis by which most cancer cells generate their energy, and so which potentially marks them out from healthy cells. Exposed to DCA, cancer cells stopped making energy from sugar and resumed making it the way healthy cells do, in chambers called mitochondria. This stopped cancer cells from growing and multiplying, and caused them to wither and ...
Visit Healthgrades for information on Dr. Wilson Chan, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Fingerprint Dive into the research topics where Katherine Chan is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Fifteen months ago Chan and Lam signed up a young, unknown actress named Cecilia Cheung, who has since blossomed as Hong Kongs latest It girl. The trio have collaborated on Twelve Nights.
... i dont drink cause i have a slight liver problem whos some of your fav anime characters who drink?. HIKE lg wyi . blt. Alcohol-chan is my spirit animal.
Chan Ho Park talks to reporters about a very special problem he had with his stomach over the last few days. His teammates have zero ability to handle the
MISSISSAUGA, ONT.In Russia last month, Patrick Chan discovered a new obstacle to Olympic gold, a threat even greater than foes like Daisuke Takahashi, Yuzuru Hanyu and Evgeni Plushenko: An upset stomach.
Taiwanese artiste Vanness Wu (吳建豪) went to the recording studio and happened to bump into Jackie Chan (成龍) and definitely will not let go of this rare opportunity to take photo together with Jackie. Subsequently on Weibo, Vanness uploaded their photo and wrote: "Da Ge (大哥), nice bumping into you at recording studio ...
In case youve never heard of Jaycee Chan, he is the son of actor Jackie Chan. This information is crucial for understanding and caring about the following piece of news. The younger Chan has been detained in Beijing during a...
GROUP securiQ.Watchdog Server: RBGN-HUB ----------------------------------------------------------------------- Your mail item contained viruses or encrypted file! Please check your harddrive! ----------------------------------------------------------------------- Mail-Info From: [email protected]@inet @ [email protected] To: [email protected] CC: Rec.: CN=Erich HAPEL/OU=32250/O=RBGN/C=AT @ RBGN Date: 01.02.2004 11:59:05 Subject: HI ----------------------------------------------------------------------- file contains virus: aul.zip ________________________________________________________________________________ Der Austausch von Nachrichten mit o.a. Absender via e-mail dient ausschliesslich Informationszwecken. Rechtsgeschaeftliche Erklaerungen duerfen ueber dieses Medium nicht ausgetauscht werden. Correspondence with a.m. sender via e-mail is only for information purposes. This medium is not to be used for the exchange of legally-binding communications ...
The movie is TEN YEAR which we mentioed a little while ago and also stars Chris Pine, Haylie Duff, Justin Long, Scott Porter, John Krasinski, Anna Faris and her husband Chris Pratt, Brian Geraghty and Kate Mara. It is an ensemble rom-com about a group of friends reuniting 10 years after leaving school. It is scheduled for release in 2011 so best we keep our eye on it and those delightful Tatums now that they have got it off the ground. ...
物理学需要有各种基本量的单位标准体系。我们目前拥有质量,长度和时间的标准定义的SI单位,千克,米,秒。力的标准单位是使用牛顿第二定律作为公理的牛顿(符号N):force =ma,使牛顿为 kg.m/s²。 力的定义决定了SI单位的能量和能量单位是焦耳,或 kg.m²/s² 或牛顿米。 新的相对论力量与力的定义如何:. f=d/dt{ (1/√(1-v²/c²)) mv} -(I). SI 单位的力量单位标准是什么?答:SI 单位没有规定相对论力学的力量标准。从肠道的感觉中,你不可思议地立即作出反应 - 怎么可能?任何人都可以创建一个力学,而且没有一个确定的标准的力量单位。没有一个确定的力量单位,他们如何计算能量的标准能量单位(工作=能量=力x距离)?我不知道 - 你可以尝试自己想一想。牛顿的SI单位来自: f=ma,相对论力来自:f=d/dt{(1/√(1-v²/c²)) mv} - ...
Film star JACKIE CHAN said that his teams LMP2 victory and overall runner-up spot in the Le Mans 24 Hours this weekend felt "exactly like when I got an Oscar." The #38 Jackie Chan DC Racing Oreca "led the race overall with just 70 minutes to go, when the recovering works Porsche 919 Hy ... Tags: People and Pop Culture. ...
http://comailab.genomecenter.ucdavis.edu/ Luca Comais Lab] at the [http://genomics.ucdavis.edu/index_html.html UC Davis Genome Center],br ...
http://www.nature.com/neuro/journal/v20/n8/full/nn.4593.html These viruses might be helpful for transducing DRG and the CNS more easily. Ive got some to try out. Ill let you know how it goes. @RPSeal @tberta
http://www.vmcs.ucdavis.edu/Lasso.acgi?-database=Orders.fp3&-response=shop/shop.html&-add Vet Med Central Services shop online],br ...
First off, I did NOT get this from 4Chan, I got it from a topic posted at GameFAQs. I posted it in YTMND form in the hope that I would get a spot in the Up and Coming for an hour or two, and an eventual 3.9, 100 votes rating. I had NO idea it would take off like it did, and frankly, I dont care. Ive read the comments that have been posted about it, and Im glad I was able to touch the hearts of as many people as I did. If you think Im all about posting sentimental crap on YTMND ...
First off, I did NOT get this from 4Chan, I got it from a topic posted at GameFAQs. I posted it in YTMND form in the hope that I would get a spot in the Up and Coming for an hour or two, and an eventual 3.9, 100 votes rating. I had NO idea it would take off like it did, and frankly, I dont care. Ive read the comments that have been posted about it, and Im glad I was able to touch the hearts of as many people as I did. If you think Im all about posting sentimental crap on YTMND ...
Bifurcating Ecologies, designed by Kenneth To (under Design Advisor, Wendy W Fok, and Project Team, Dave Cheung, Marco Chan), is a developmental...
Perhaps youve read it in the sidebar. In one of the random quotations I quote my friend Chan: I am instinctively suspicious of any garden writer (or garde
Hi I woke on Thursday morning last week to my machine in a constant boot loop, with a BSOD appearing over and over. I tried startup recovery and system restore, neither of which were able to make chan
Looking for online definition of Chan Su in the Medical Dictionary? Chan Su explanation free. What is Chan Su? Meaning of Chan Su medical term. What does Chan Su mean?
The lethal marine toxin, palytoxin, first extracted from the polyps of soft-bodied zoanthids of the genus Palythoa (Moore and Scheuer, 1971), is a potentially useful tool for elucidating the molecular reactions by which the Na/K-ATPase stoichiometrically transports Na+ and K+ ions in opposite directions across the cell surface membrane. Palytoxin was found to depolarize mammalian cells (e.g., Weidmann, 1977) by causing small-conductance (∼10 pS) relatively nonselective cation channels to appear in their surface membranes (e.g., Ikeda et al., 1988; Muramatsu et al., 1988). That the Na/K-ATPase is the target for palytoxin action was initially surmised (Habermann, 1989) largely from antagonism of toxin action by cardiotonic steroids, like ouabain, or by K+ ions. Two experimental approaches have since confirmed that proposal. The first exploited the absence of endogenous Na/K pumps from yeast and showed that palytoxin could elicit ouabain-sensitive cation flux in yeast expressing both α and β ...
Ouabain, that has been isolated from bovine adrenals and hypothalamus, is a new cardiotonic steroid hormone, which is either synthesized in the adrenals or stored there after it has absorbed from the diet. Little is known ,i,in vivo,/i, which events may lead to the release of ouabain into blood. Moreover, a binding protein for cardiotonic steroids exists in blood, which binds cardiac glycosides with high affinity. It may affect the action of endogenous ouabain on heart and circulation, but the physiological function of this protein is unclear. To realize, which physiological stimuli ,i,in vivo,/i, may affect blood concentrations of endogenous ouabain and which function the cardiotonic binding protein may have in modulating ouabain effects, the effect of physical exercise on endogenous ouabain was studied and the tissue distribution of its binding protein was investigated. We found that endogenous ouabain changes rapidly in blood upon physical exercise and behaves like expected for a hormone of ...
TY - JOUR. T1 - Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits. AU - Szilvássy, Z.. AU - Koltai, Matyas. AU - Ferdinándy, P.. AU - Jakab, Ildiko. AU - Lonovics, J.. AU - Tarrade, Thierry. AU - Allard, Michel. AU - Braquet, Pierre G.. PY - 1994. Y1 - 1994. N2 - Myocardial ischemia assessed by intracavital ST-segment elevation, shortening of ventricular effective refractory period (VERP), and increase in left ventricular end-diastolic pressure (LVEDP) was provoked by ventricular overdrive pacing (VOP) in conscious rabbits. Cromakalim (10 μg/kg), an ATP-sensitive K+ channel opener, and cicletanine (30 mg/kg), a cGMP-phosphodiesterase inhibitor, reduced VOP-induced ST-segment elevation and LVEDP-increase. Under resting conditions, cromakalim lowered blood pressure, increased heart rate (HR), and shortened VERP, whereas cicletanine decreased HR, prolonged VERP without changing blood pressure. Co-administration of cromakalim and cicletanine additively ...
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD), but the underlying mechanisms contributing to this complex phenotype are incompletely understood. Myocardial deformation analyses (ventricular strain) of patients with mild CKD have recently been reported to predict adverse clinical outcome. We aimed to determine if early myocardial dysfunction in a mouse model of CKD could be detected using ventricular strain analyses. CKD was induced in 5-week-old male 129X1/SvJ mice through partial nephrectomy (5/6Nx) with age-matched mice undergoing bilateral sham surgeries serving as controls. Serial transthoracic echocardiography was performed over 16 weeks following induction of CKD. Invasive hemodynamic measurements were performed at 8 weeks. Gene expression and histology was performed on hearts at 8 and 16 weeks. CKD mice developed decreased longitudinal strain (-25 ± 4.2% vs. -29 ± 2.3%; P = 0.01) and diastolic dysfunction ...
View Notes - Chan, Gennerich - Pediatrics from ECON 123 at Pontificia Universidad Catolica Madre y Maestra. Current Clinical Strategies Pediatrics 2004 Edition Paul D. Chan, MD Jane L. Gennrich,
We are looking for a Data Analyst to join the IT team. This is a detailed, technical, numeric and analytical role; ensuring the integrity of data and providing a quality of analysis and reporting in a dynamic and multi-dimensional environment. Current databases include; the fundraising database, ThankQ CRM (TQ), the accounting application Microsoft Dynamics GP 2010 (GP 2010), and significant other external data interfaces ...
Induction by Bufalin of Differentiation of Human Leukemia Cells HL60, U937, and ML1 toward Macrophage/Monocyte-like Cells and Its Potent Synergistic Effect on the Differentiation of Human Leukemia Cells in Combination with Other Inducers." Cancer Research 53.4 (1993): 934. Web. 18 Dec. 2017. ...
This patch fixes the following test failure: , --- box/push.result Thu Jan 24 13:10:04 2019 , +++ var/001_box/push.result Thu Jan 24 13:13:08 2019 , @@ -536,17 +536,3 @@ , --- , ... , chan_disconnected:get() , ---- , -- true , -... , -chan_push:put(true) , ---- , -- true , -... , -chan_push:get() , ---- , -- Session is closed , -... , -box.schema.func.drop(do_long_and_push) , ---- , -... The problem occurs because the main fiber may close the connection before do_long_and_push sets the session.on_disconnect trigger, in which case chan_disconnected:get() will never return. Fix this by setting the trigger in the main fiber and adding another channel to wait for do_long_and_push function to start. Also, dont forget to clear the trigger once the test is complete. Fixes commit 43af2de2b129 (session: outdate a session of a closed connection). Closes #3947 --- https://github.com/tarantool/tarantool/issues/3947 https://github.com/tarantool/tarantool/commits/dv/test-fixes test/box/push.result , 15 ...
Full text of the opinion issued by the Department of Justice on the issue of whether the Internet constitutes mass media. Featured on-line by Chan Robles & Associates Law Firm.
by Wang, Kai and Yuen, Siu Tsan and Xu, Jiangchun and Lee, Siu Po and Yan, Helen H N and Shi, Stephanie T and Siu, Hoi Cheong and Deng, Shibing and Chu, Kent Man and Law, Simon and Chan, Kok Hoe and Chan, Annie S Y and Tsui, Wai Yin and Ho, Siu Lun and Chan, Anthony K W and Man, Jonathan L K and Foglizzo, Valentina and Ng, Man Kin and Chan, April S and Ching, Yick Pang and Cheng, Grace H W and Xie, Tao and Fernandez, Julio and Li, Vivian S W and Clevers, Hans and Rejto, Paul A and Mao, Mao and Leung, Suet Yi ...
Latest issuances of the Bureau of Postharvest Research and Extension (BPRE). Published on the World Wide Web by The Law Firm of Chan Robles and Associates - Philippines.
Find out more information about Professor Kelvin Chan, including their areas of expertise, research publications and contact details.
Cure WorldCosplay is a free website for submitting cosplay photos and is used by cosplayers in countries all around the world. Even if youre not a cosplayer yourself, you can still enjoy looking at high-quality cosplay photos from around the world.
After spending 56 years in the movies, Jackie Chan received an honorary Oscar in 2016, but the action star says he does not work for awards and his only motivation is his fans.
J.P. Brady, P.J. Farber, A. Sekhar, Y.-H. Lin, R. Huang, A. Bah, T.J. Nott, H.S. Chan, A.J. Baldwin, J.D. Forman-Kay and L.E. Kay (2017). Structural and Hydrodynamic Properties of An Intrinsically Disordered Region of A Germ-Cell Specific Protein on Phase Separation. Proceedings of the National Academy of Sciences, USA 114, E8194-E8203 [Download combined pdf file for Main Text & Supporting Information ...
Bollywoods Amitabh Bachchan and martial arts movie star Jackie Chan are among celebrities who feature Monday in a massive leak of documents, some of which reveal hidden offshore assets.
In a new "Go Tagless" TV ad campaign to promote the Hanes Tagless Undershirt, action star Jackie Chan becomes so irritated by his itchy T-shirt tag that he performs daring acrobatic feats in an effort to scratch the offending area.
Nigeria News - The home-based Super Eagles will now miss out of the party at the CHAN 2020 in Cameroon in spite of a 2-0 win against Togo.
by Kim, Ji-Woon and Kim, Ji-Woon and Seung, Hana and Seung, Hana and Kwon, Kyung J.a and Kwon, Kyung Ja and Ko, Mee J.ung and Ko, Mee Jung and Lee, Eun J.oo and Lee, Eun Joo and Oh, Hyun Ah and Oh, Hyun A.h and Choi, Chang S.oon and Choi, Chang Soon and Kim, Ki Chan and Kim, Ki C.han and Gonzales, Edson Luck and Gonzales, Edson L.uck and You, Jueng Soo and You, Jueng S.oo and Choi, Dong-Hee and Choi, Dong-Hee and Lee, Jongmin and Lee, Jongmin and Han, Seol-Heui and Han, Seol-Heui and Yang, Sung Min and Yang, Sung M.in and Cheong, Jae Hoon and Cheong, Jae H.oon and Shin, Chan Y.oung and Shin, Chan Young and Bahn, Geon Ho and Bahn, Geon H.o ...
This may open the possibility of players taking tier sets to take advantage of superior set bonuses. This would be particularly attractive to RBG FCs, as PVP power isnt important to them, resilience wont be on gear anymore, and no PVP sets are tailored for flag carriers ...
Knafo S,* Sanchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordonez-Gutierrez L, Wandosell F, Vina J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C,* Esteban JA ...
If you are going to continue to use the high VG Elements I would not recommend using the higher resistance coils. Those liquids are serious coil-killers and I would expect running at low(ish)-wattage needed for the 1.0 coils you will get dry hits and would be lucky to get through a couple of tanks before your coils are dead ...
โทรสาร 039-340059. You can always booking before go there.. They provide free drink ( Gingle Drink or Mineral Water ). [mappress mapid="19″]. ...
Authors: Leong, K. P.; L. Yeak, S. C.; M. Saurajen, A. S.; H. Mok, P. K.; Earnest, A.; Siow, J. K.; C. Chee, N. W.; Yeo, S. B.; Khoo, M. L.; Y. Lee, J. C.; Seshadri, R.; Chan, S. P.; Tang, C. Y.; Chng, H. H. ...
Xiu-Sheng Miao, Pengfei Song, Ronald E. Savage, Caiyun Zhong, Rui-Yang Yang, Darin Kizer, Hui Wu, Erika Volckova, Mark A. Ashwell, Jeffrey G. Supko, Xiaoying He and Thomas C. K. Chan ...
Hongguang Li, Bethany I. Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, Bich-Thuy Doan, Ka-Lok Ho, Chi-Fai Chan, Wai-Sum Lo, René M. Botnar, Rongfeng Lan, Cyrille Richard, Ga-Lai Law, Nicholas J. Long, Ka-Leung Wong ...
Chan, W.K.; Haverkate, L.A.; Borghols, W.J.H.; Wagemaker, M. ; Picken, S.J.; Eck, E.R.H. van ; Kentgens, A.P.M. ; Johnson, M.R.; Kearley, G.J.; Mulder, F.M. ...
Lopburi (ลพบุรี), also Lop Buri or Lob Buri is a historic city 3 hours north of Bangkok in the Chao Phraya Basin region of Thailand. Lopburi has a mountain called Khao Chan Daeng.
Lopburi (ลพบุรี), also Lop Buri or Lob Buri is a historic city 3 hours north of Bangkok in the Chao Phraya Basin region of Thailand. Lopburi has a mountain called Khao Chan Daeng.
Forex brokers that offer micro lots #### DAILY CHART ANALYSIS FOREX How to create your own forex robot #### Algorithmic trading winning strategies and their rationale by ernie chan
In the case Waliyah v Yip Hoi Sun Terence and Chan Man Hong (DCEO 1/2015 and DCCJ 1041/2015), the First Respondent ("R1") and the Second Respondent…
-- Warning, despite my efforts to keep it clean and sophisticated, this entry is still not recommended for the squeamish or the Amish. I realize its been a while since Id written something about defecation. Normally I leave that to the experts like naka_chan, but last nights violent ordeal…
Kaazempur-Mofrad, M.R., Bathe, M., Karcher, H., Younis, H.F., Seong, H.C., Shim, E.B., Chan, R.C., Hinton, D.P., Isasi, A.G., Upadhyaya, A., Powers, M.J., Griffith, L.G., and Kamm, R.D.. Computers & Structures, 81: 715 (2003). ...
TY - JOUR. T1 - 放射線檢查之用藥安全流程. AU - Hsieh, Ming Chih. AU - Chen, Clayton Chi Chang. AU - Lee, R. C.. AU - Chan, Wing P.. PY - 2008/6. Y1 - 2008/6. N2 - 用藥安全是病人安全極重要的一環,也是放射線科高度重視的課題。本文將討論放射線檢查之用藥安全流程,包括注射含碘對比劑造成滲漏、過敏或對比劑造成的腎毒性;注射含釓類對比劑發生腎因性全身纖維硬化症、其他對比劑或藥物的注意事項。以期讓病人在接受檢查的過程,做好事先預防或減少對比劑造成的不良反應的措施。. AB - ...
Regulator of G protein signaling 2 (RGS2), a Gq-specific GTPase activator protein (GAP), is strongly implicated in cardiovascular function. RGS2-/- mice are hypertensive and prone to heart failure and several rare human mutations that speed RGS2 degradation have been identified in hypertensive patients. Consequently, pharmacological up-regulation of RGS2 protein levels could be beneficial. We utilized a β-galactosidase complementation method to screen several thousand compounds with known pharmacological function for those that increase RGS2 protein levels. Several cardiotonic steroids (CTS), including ouabain and digoxin increase RGS2 but not RGS4 protein levels. CTS increase RGS2 protein levels through a posttranscriptional mechanism by slowing protein degradation. RGS2 mRNA levels in primary vascular smooth muscle cells are unaffected by CTS treatment while protein levels are increased 2-3 fold. Na/K-ATPase is required for the increase in RGS2 protein levels as the effect is lost in ...
Dr. Steven Chans research focus has been to develop novel approaches to target mutations that have been identified through whole genome sequencing efforts in the past 10 years. Although our understanding of the underlying mutations that drive cancer has tremendously improved, the majority of the mutations are unfortunately not easily "druggable" in part because many of them result in a loss-of-function phenotype. If the goal of personalized medicine is to be realized, new therapeutic strategies that specifically target these mutations are required in the armament of drugs. Dr. Chan views this as one of the main challenges facing translational cancer research today.. Chan SM, Thomas D, Cores-Zimmerman MR, Xavy S, Rastogi S, Hong WJ, Zhao F, Medeiros BC, Tyvoll DA, Majeti R. 2015. Isocitrate Dehydrogenase 1 and 2 Mutations Induce BCL-2 Dependence in Acute Myeloid Leukemia. Nature Medicine. 21(2):178-84.. In the above manuscript, Dr. Chan applied the synthetic lethality strategy to target the ...
Chan Ya-Chung is Vice President:Business at Taiwan Chinsan Electronic Industrial Co Ltd. See Chan Ya-Chungs compensation, career history, education, & memberships.
When viewing Taiwanese artist Lo Chan Pengs body of work, the artists devotion to his specific subjects becomes immediately apparent. Lo will do numerous iterations of the same work, almost like multiple photo takes for a fashion editorial, rendering the same model from various angles and exploring the visual richness of her often-elaborate costume. Except these renditions are not quick sketches, but fully-fledged oil-on-canvas paintings that often span one, if not two, meters in each direction. Los work straddles the boundary between beauty and disgust. His doe-eyed vixens dazzle with pop star good looks, but upon closer inspection, their blue veins, visible wounds and glazed-over eyes reveal the works disturbing dimension. Take a look at Lo Chan Pengs recent oil paintings below.. ...
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Certain steroids obtained from plants are potent inhibitors of the Sodium-Potassium pump. Digitoxigenin and ouabain are members of this class of inhibitors, which are known as cardiotonic steroids because of their effects on the heart. These compounds inhibit the dephosphorylation of the E2-P form of the ATPase when applied on the extracellular face of the membrane. Digitalis is a mixture of cardiotonic steroids derived from the dried leaf of the foxglove plant (Digitalis purpurea). The compound increases the force of contraction produced by the heart, and is the drug of choice in heart failure. The inhibition of the sodium potassium pump by Digitalis leads to a higher level of Na+ inside the cell. The diminished Na+ gradient results in a slower intrusion of Ca2+ by the sodium-calcium exchanger. The increase of Ca2+ enhances the ability of the cardiac muscle to contract. Digitalis was being used long before its discovery through foxglove extract. People were using it to cure people with ...
Bufotoxins are a family of toxic steroid lactones. They occur in the parotoid glands, skin and poison of many toads (genus Bufo) and other amphibians, and in some plants and mushrooms. The exact composition varies greatly with the specific source of the toxin. It can contain: 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, epinephrine, norepinephrine, and serotonin. The term bufotoxin can also be used specifically to describe the conjugate of a bufagin with suberylargine. The toxic substances found in toads can be divided by chemical structure in two groups: bufadienolides which are cardiac glycosides (e.g. bufotalin, bufogenin) tryptamine related substances (e.g. bufotenin) Toads known to secrete bufotoxin are:[citation needed] Bufo alvarius Bufo americanus Bufo arenarum Bufo asper Bufo blombergi Bufo boreas Bufo bufo Bufo bufo gargarizans Bufo Gutturalis Bufo formosus Bufo fowleri Rhinella marina (formerly Bufo marinus) Bufo melanostictus Bufo peltocephalus Bufo quercicus ...
Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive ...
Background: Uremic cardiomyopathy is responsible for high morbidity and mortality in patients with chronic kidney disease (CKD), which is characterized by cardiac hypertrophy and heart failure. But precise mechanisms are still unknown. In our previous data, soluble Flt-1 (sFlt-1), which is an endogenous inhibitor of PLGF (placental growth factor), is a key molecule of cardiovascular disease in CKD. Soluble Flt-1 production was decreased with the progression of renal diseases, and sFlt-1 deficiency resulted in progression of cardiac hypertrophy and heart failure, which was revealed by using sFlt-1 KO mice (sFlt-1-/-). In this study, we examined the novel mechanisms of heart failure and cardiac hypertrophy using sFlt-1-/- mice which mimic the CKD condition.. Methods and Results: We performed transverse aortic constriction (TAC) in sFlt-1-/- and WT, and evaluated after 7 days. LV wall thickening was significantly increased and ejection fraction was decreased in sFlt-1-/- compared to WT by ...

Bufanolide | definition of bufanolide by Medical dictionaryBufanolide | definition of bufanolide by Medical dictionary

... bufanolide explanation free. What is bufanolide? Meaning of bufanolide medical term. What does bufanolide mean? ... Looking for online definition of bufanolide in the Medical Dictionary? ... Bufanolide , definition of bufanolide by Medical dictionary https://medical-dictionary.thefreedictionary.com/bufanolide ... bufanolide. Also found in: Wikipedia. bu·fan·o·lide. (bū-fanō-līd), The fundamental steroid lactone of several vegetable (for ...
more infohttps://medical-dictionary.thefreedictionary.com/bufanolide

Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha | WaterstonesSpectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha | Waterstones

Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha from Waterstones today! Click and Collect from your local ... Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides: Volume 3 (Paperback). Viqar Uddin Ahmad ( ...
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Bufatrienolide | definition of bufatrienolide by Medical dictionaryBufatrienolide | definition of bufatrienolide by Medical dictionary

bufanolide. (redirected from bufatrienolide) bu·fan·o·lide. (bū-fanō-līd), The fundamental steroid lactone of several ...
more infohttp://medical-dictionary.thefreedictionary.com/bufatrienolide

Category:Steroids - Wikimedia CommonsCategory:Steroids - Wikimedia Commons

esteroide (es); Стероидтар (kk-kz); Steroid (ms); ستەروىيدتار (kk-cn); Стероид (bg); Steroid (ro); 甾體 (zh-hk); Steroid (sk); Esteroïde (oc); 甾體 (zh-hant); 甾体 (zh-cn); 스테로이드 (ko); Стероидтар (kk); steroido (eo); steroidy (cs); Steroidogeneza (bs); স্টেরয়েড (bn); stéroïde (fr); Steroid (jv); steroid (hr); סטערויד (yi); Steroid (vi); ستەروىيدتار (kk-arab); Steroïdtar (kk-latn); Steroïed (af); Стероиди (sr); 甾体 (zh-sg); Стероидтар (kk-cyrl); steroid (nn); steroid (nb); Stéroid (su); steroid (en); ستيرويد (ar); 類固醇 (yue); Steroïdtar (kk-tr); Esteroide (eu); Esteroide (ast); esteroide (ca); Steroid (cy); Stéaróideach (ga); ստերոիդներ (hy); 甾體 (zh); steroid (da); ステロイド (ja); סטרואיד (he); स्टेरॉयड (hi); Steroidi (fi); steroide (it); Estewoyid (ht); Стэроіды (be-tarask); Στεροειδές (el); steroīds ...
more infohttps://commons.wikimedia.org/wiki/Category:Steroids

Analysis and characterization of steroids (Book, 1992) [WorldCat.org]Analysis and characterization of steroids (Book, 1992) [WorldCat.org]

Cardenolides and bufanolides --. Ecdysteroids --. Estrogens --. Pregnanes and corticoids --. Sterols --. Vitamin D.. Series ... Cardenolides and bufanolides -- Ecdysteroids -- Estrogens -- Pregnanes and corticoids -- Sterols -- Vitamin D."@en ;. schema: ...
more infohttp://www.worldcat.org/title/analysis-and-characterization-of-steroids/oclc/25281821

LIPID MAPS Lipidomics GatewayLIPID MAPS Lipidomics Gateway

Bufanolides and derivatives [ST0113]. Brassinolides and derivatives [ST0114]. Solanidines and alkaloid derivatives [ST0115] ...
more infohttp://lipidmaps.org/data/classification/LM_classification_exp.php?category=5

NaK alpha1-subunit and in vitro growth inhibition of ca | Open-iNaK alpha1-subunit and in vitro growth inhibition of ca | Open-i

Bufanolides/chemistry/metabolism/pharmacology*/toxicity. *Neoplasms/metabolism*. *Sodium-Potassium-Exchanging ATPase/ ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3722118_1476-4598-12-33-2&req=4

Find Research Outputs
             - Hungarian ConsortiumFind Research Outputs - Hungarian Consortium

Lanen, J. B. J. M., Lovas, R. G., Kruppa, A., Blok, H. P., Van Den Brand, J. F. J., Ent, R., Jans, E., Kramer, G. J., Lapiks, L., Quint, E. N. M., Van Der Steenhoven, G., Tiemeijer, P. C. & De Witt Huberts, P. K. A., 1989, In : Physical Review Letters. 63, 26, p. 2793-2796 4 p.. Research output: Contribution to journal › Article ...
more infohttps://hungary.pure.elsevier.com/en/publications/?format=&ordering=type&descending=false

steroid | Definition, Structure, & Types | Britannica.comsteroid | Definition, Structure, & Types | Britannica.com

Cardanolide and bufanolide derivatives, found in many plants and in the skin of toads, cause vomiting, visual disturbances, and ... except in the cardanolides and bufanolides; compounds of these types characteristically possess the 5β,14β configurations, ...
more infohttps://www.britannica.com/science/steroid

Praveen Kumar - Fingerprint
     - University of Illinois at Urbana-ChampaignPraveen Kumar - Fingerprint - University of Illinois at Urbana-Champaign

Fingerprint Fingerprint is based on mining the text of the experts scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher. ...
more infohttps://experts.illinois.edu/en/persons/praveen-kumar/fingerprints/

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             - Arizona State UniversityFind Scholarly Works - Arizona State University

Barber, R. C., Bishop, R. L., Duckworth, H. E., Meredith, J. O., Southon, F. C. G., Van Rookhuyzen, P. & Williams, P., 1971, In : Review of Scientific Instruments. 42, 1, p. 1-8 8 p.. Research output: Contribution to journal › Article ...
more infohttps://asu.pure.elsevier.com/en/publications/?page=12&showAdvanced=false&allConcepts=true&inferConcepts=true%E2%88%A8iginalSearch%3D&improvedLayoutOrganisationUuid=&format=&descending=false

2-Pyrone - Wikipedia2-Pyrone - Wikipedia

The most common natural products containing a 2-pyrone are the bufanolides and kavalactones. Oxovitisin A, a pyranoanthocyanin ...
more infohttps://en.wikipedia.org/wiki/2-Pyrone

Arenobufagin - WikipediaArenobufagin - Wikipedia

Arenobufagin is a cardiotoxic bufanolide steroid secreted by the Argentine toad Bufo arenarum. It has effects similar to ...
more infohttps://en.wikipedia.org/wiki/Arenobufagin

Proscillaridin - wikidocProscillaridin - wikidoc

It is of the bufanolide type and can be obtained from plants of the genus Scilla, notably Scilla maritima. ...
more infohttps://www.wikidoc.org/index.php/Proscillaridin

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5β,14β- bufanolide. C24H38O2. 3β,14-˫?ǻ?-5β,14β-?? -20(22)-ϩ?? ë ػ ??Ԫ ...
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JNK Inhibitors | Kinase Inhibitors on JNK Signaling Pathways | AbMole BioScienceJNK Inhibitors | Kinase Inhibitors on JNK Signaling Pathways | AbMole BioScience

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans.. ...
more infohttp://www.abmole.com/pharmacological/jnk.html

The Moringa Herbalist: Moringa Sustains Cardio Vascular SystemThe Moringa Herbalist: Moringa Sustains Cardio Vascular System

The bufanolides occur in some Liliacea, such as Squill (Urginea maritima), and in some Ranunculaceae. Some of the main genera ...
more infohttp://moringaleaves.blogspot.com/2008/08/moringa-sustains-cardio-vascular-system.html

NAVER Academic > Search...NAVER Academic > Search...

Animals, Antineoplastic Agents, pharmacology, Bufanolides, Cell Line, Tumor, Cell Proliferation, drug effects, Endometrial ...
more infohttps://academic.naver.com/search.naver?field=3&query=Chinese+Journal+of+Integrated+Traditional+and+Western+Medicine+30%EA%B6%8C+11%ED%98%B8

Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by...Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by...

Bufanolides/administration & dosage*. *Bufanolides/pharmacology. *Carcinoma, Hepatocellular/drug therapy*. *Carcinoma, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?term=29620259

Did you know that the Yesterday, Today and Tomorrow is toxic to dogs? | 8ightDid you know that the Yesterday, Today and Tomorrow is toxic to dogs? | 8ight

Round-leafed Navel-wort (Cotyledon orbiculata): The leaves from this plant contain a bufanolide called cotyledontoxin that is ...
more infohttps://infinity8eight.wordpress.com/2014/02/03/yesterday-today-and-tomorrow/

Download Teach Yourself Visually Office 2013 2013Download Teach Yourself Visually Office 2013 2013

Author: Ahmad, VU and Basha, APublisher: Springer, only Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides, Vol ... Author: Ahmad, VU and Basha, APublisher: Springer, previous Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides ...
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