A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.
Sequential operating programs and data which instruct the functioning of a digital computer.
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
Prospective patient listings for appointments or treatments.
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Hydrochloric acid present in GASTRIC JUICE.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AMINO ACIDS.
One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The optically determined size of exo/endo cycling vesicle pool correlates with the quantal content at the neuromuscular junction of Drosophila larvae. (1/2312)

According to the current theory of synaptic transmission, the amplitude of evoked synaptic potentials correlates with the number of synaptic vesicles released at the presynaptic terminals. Synaptic vesicles in presynaptic boutons constitute two distinct pools, namely, exo/endo cycling and reserve pools (). We defined the vesicles that were endocytosed and exocytosed during high K+ stimulation as the exo/endo cycling vesicle pool. To determine the role of exo/endo cycling vesicle pool in synaptic transmission, we estimated the quantal content electrophysiologically, whereas the pool size was determined optically using fluorescent dye FM1-43. We then manipulated the size of the pool with following treatments. First, to change the state of boutons of nerve terminals, motoneuronal axons were severed. With this treatment, the size of exo/endo cycling vesicle pool decreased together with the quantal content. Second, we promoted the FM1-43 uptake using cyclosporin A, which inhibits calcineurin activities and enhances endocytosis. Cyclosporin A increased the total uptake of FM1-43, but neither the size of exo/endo cycling vesicle pool nor the quantal content changed. Third, we increased the size of exo/endo cycling vesicle pool by forskolin, which enhances synaptic transmission. The forskolin treatment increased both the size of exo/endo cycling vesicle pool and the quantal content. Thus, we found that the quantal content was closely correlated with the size of exo/endo cycling vesicle pool but not necessarily with the total uptake of FM1-43 fluorescence by boutons. The results suggest that vesicles in the exo/endo cycling pool primarily participate in evoked exocytosis of vesicles.  (+info)

Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. (2/2312)

We have previously reported that intrabursal ovarian administration of LH at the end of pregnancy in rats induces a decrease in luteal progesterone (P4) synthesis and an increase in P4 metabolism. However, whether this local luteolytic effect of LH is exerted directly on luteal cells or on other structures, such as follicular or stromal cells, to modify luteal function is unknown. The aim of the present study was to determine the effect of LH on isolated luteal cells obtained on Day 19 of pregnancy. Incubation of luteal cells with 1, 10, 100, or 1000 ng/ml of ovine LH (oLH) for 6 h did not modify basal P4 production. The addition to the culture medium of 22(R)-hydroxycholesterol (22R-HC, 10 microgram/ml), a membrane-permeable P4 precursor, or pregnenolone (10(-2) microM) induced a significant increase in P4 accumulation in the medium in relation to the control value. When luteal cells were preincubated for 2 h with oLH, a significant (p < 0.01) reduction in the 22R-HC- or pregnenolone-stimulated P4 accumulation was observed. Incubation of luteal cells with dibutyryl cAMP (1 mM, a cAMP analogue) plus isobutylmethylxanthine (1 mM, a phosphodiesterase inhibitor) also inhibited pregnenolone-stimulated P4 accumulation. Incubation with an inositol triphosphate synthesis inhibitor, neomycin (1 mM), or an inhibitor of intracellular Ca2+ mobilization, (8,9-N, N-diethylamino)octyl-3,4,5-trimethoxybenzoate (1 mM), did not prevent the decrease in pregnenolone-stimulated P4 secretion induced by oLH. It was concluded that the luteolytic action of LH in late pregnancy is due, at least in part, to a direct action on the luteal cells and that an increase in intracellular cAMP level might mediate this effect.  (+info)

D-Aspartate stimulation of testosterone synthesis in rat Leydig cells. (3/2312)

D-Aspartate increases human chorionic gonadotropin-induced testosterone production in purified rat Leydig cells. L-Aspartate, D-,L-glutamate or D-,L-asparagine could not substitute for D-aspartate and this effect was independent of glutamate receptor activation. Testosterone production was enhanced only in cells cultured with D-aspartate for more than 3 h. The increased production of testosterone was well correlated with the amounts of D-aspartate incorporated into the Leydig cells, and L-cysteine sulfinic acid, an inhibitor of D-aspartate uptake, suppressed both testosterone production and intracellular D-aspartate levels. D-Aspartate therefore is presumably taken up into cells to increase steroidogenesis. Intracellular D-aspartate probably acts on cholesterol translocation into the inner mitochondrial membrane, the rate-limiting process in steroidogenesis.  (+info)

Overexpression of nucleoside diphosphate kinases induces neurite outgrowth and their substitution to inactive forms leads to suppression of nerve growth factor- and dibutyryl cyclic AMP-induced effects in PC12D cells. (4/2312)

Whether nucleoside diphosphate kinase (NDPK) is involved in neuronal differentiation was investigated with special reference to its enzyme activity. Neurite outgrowth of PC12D cells induced by nerve growth factor or a cyclic AMP analog was suppressed to some extent when inactive NDPKs (the active site histidine 118 was replaced with alanine), not active forms, were transiently overexpressed. This suppression was more definite in their stably expressed clones. NDPKbeta-transfected clones and, to a lesser extent, NDPKalpha-transfected clones, but not inactive NDPK-transfected clones, extended neurites without differentiation inducers. These results imply that NDPKs may play a role by exerting their enzyme activity during differentiation of PC12 cells.  (+info)

Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease. (5/2312)

The retinoblastoma protein plays a critical role in regulating the G1/S transition. Less is known about the function and regulation of the homologous pocket protein p107. Here we present evidence for the posttranslational regulation of p107 by the Ca2+-activated protease calpain. Three negative growth regulators, the HMG-CoA reductase inhibitor lovastatin, the antimetabolite 5-fluorouracil, and the cyclic nucleotide dibutyryl cAMP were found to induce cell type-specific loss of p107 protein which was reversible by the calpain inhibitor leucyl-leucyl-norleucinal but not by the serine protease inhibitor phenylmethylsulfonylfluoride, caspase inhibitors, or lactacystin, a specific inhibitor of the 26S proteasome. Purified calpain induced Ca2+-dependent p107 degradation in cell lysates. Transient expression of the specific calpain inhibitor calpastatin blocked the loss of p107 protein in lovastatin-treated cells, and the half-life of p107 was markedly lengthened in lovastatian-treated cells stably transfected with a calpastatin expression vector versus cells transfected with vector alone. The data presented here demonstrate down-regulation of p107 protein in response to various antiproliferative signals, and implicate calpain in p107 posttranslational regulation.  (+info)

Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. (6/2312)

The Janus kinase, JAK3 plays an important role in interleukin-2 (IL-2)-dependent signal transduction and proliferation of T lymphocytes. Our findings show that prostaglandin E2 (PGE2) can inhibit upregulation of JAK3 protein in naive T cells and can downregulate its expression in primed cells. Reduction in JAK3 was selective because expression of other tyrosine kinases (JAK1, p56(lck), and p59(fyn)) and signal transducer and activator of transcription (STAT)5, which are linked to IL-2 receptor (IL-2R) signaling pathway, were not affected. Inhibition of JAK3 may be controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, as forskolin, a direct activator of adenylate cyclase and dibutyryl cAMP (dbcAMP), a membrane permeable analogue of cAMP suppressed JAK3 expression. Moreover, 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of cAMP phosphodiesterase, potentiated PGE2-induced suppression of JAK3. In naive T cells, but not primed T cells, PGE2 and other cAMP elevating agents also caused a modest reduction in surface expression of the common gamma chain (gammac) that associates with JAK3. The absence of JAK3, but not IL-2R in T cells correlated with impaired IL-2-dependent signal transduction and proliferation. The alteration in IL-2 signaling included decreased tyrosine phosphorylation and DNA binding activity of STAT5 and poor induction of the c-Myc and c-Jun pathways. In contrast, IL-2-dependent induction of Bcl-2 was unaffected. These findings suggest that suppression of JAK3 levels may represent one mechanism by which PGE2 and other cAMP elevating agents can inhibit T-cell proliferation.  (+info)

cAMP-dependent induction of PDE5 expression in murine neuroblastoma cell differentiation. (7/2312)

The present study demonstrates, in both hybrid NG108-15 and mouse neuroblastoma N18TG2 cells, the presence and regulation of PDE5 mRNA during cell differentiation. PDE5 cDNA probes in Northern blot analysis recognize a approximately 9 kb transcript in bovine lung as well as in mouse neuroblastoma cells. Hybridization on total RNA extracted from dibutyryl-cAMP-treated NG108-15 cells shows a 5-fold increase of PDE5 9 kb mRNA: such an increase is not observed in N18TG2 although we observed a similar increase in the enzymatic activity of both cell lines. Our data demonstrate that PDE5 gene expression can be regulated by cAMP and suggest the existence of a complex regulatory system for PDE5 activity.  (+info)

Caffeine does not inhibit substance P-evoked intracellular Ca2+ mobilization in rat salivary acinar cells. (8/2312)

We used the Ca2+-sensitive fluorescent dye fura 2, together with measurements of intracellular D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], to assess the inhibitory effects of caffeine on signal transduction via G protein-coupled receptor pathways in isolated rat mandibular salivary acinar cells. ACh, norepinephrine (NE), and substance P (SP) all evoked substantial increases in the intracellular free Ca2+ concentration ([Ca2+]i). Responses to ACh and NE were markedly inhibited by prior application of 20 mM caffeine. The inhibitory effect of caffeine was not reproduced by phosphodiesterase inhibition with IBMX or addition of cell-permeant dibutyryl cAMP. In contrast to the ACh and NE responses, the [Ca2+]i response to SP was unaffected by caffeine. Despite this, SP and ACh appeared to mobilize Ca2+ from a common intracellular pool. Measurements of agonist-induced changes in Ins(1,4,5)P3 levels confirmed that caffeine inhibited the stimulus-response coupling pathway at a point before Ins(1,4,5)P3 generation. Caffeine did not, however, inhibit [Ca2+]i responses evoked by direct activation of G proteins with 40 mM F-. These data show that caffeine inhibits G protein-coupled signal transduction in these cells at some element that is common to the muscarinic and alpha-adrenergic signaling pathways but is not shared by the SP signaling pathway. We suggest that this element might be a specific structural motif on the G protein-coupled muscarinic and alpha-adrenergic receptors.  (+info)

TY - JOUR. T1 - Synchronization of meiosis in porcine oocytes by exposure to dibutyryl cyclic adenosine monophosphate improves developmental competence following in vitro fertilization. AU - Funahashi, Hiroaki. AU - Cantley, Thomas C.. AU - Day, Billy N.. PY - 1997/7/1. Y1 - 1997/7/1. N2 - The effect of stage of maturation of the germinal vesicle of porcine oocytes at the time of in vitro maturation on subsequent developmental competence was examined. A large variation exists in the germinal vesicle morphology of oocytes at the time of collection of cumulus-oocyte complexes (COCs) and after culture in the absence of dibutyryl cAMP (dbcAMP) for 20 h. However, the morphology of the germinal vesicle was synchronized to a specific stage after culture in the presence of 1 mM dbcAMP for 20 h. There was no difference in germinal vesicle breakdown rate (total mean, 75.0 ± 5.4%) or in maturation rate (total mean, 82.1 ± 2.1%) at 28 and 44 h of culture, respectively. However, differences in meiotic ...
The effects of dibutyryl cyclic adenosine monophosphate (dB-cAMP) were studied in fifty cats, twenty anesthetized with pentobarbital and thirty with halothane. Nasopharyngeal temperature and Paco2 were maintained at normal values. Somatosensory evoked response was monitored and used as an indicator of cerebral cortical function. Ischemic hypoxic injury was produced by an orthopedic tourniquet snugly applied around the animals neck and inflated for a period of fifteen minutes. This method produces a reliable and reproducible injury. Times for recovery of the evoked response to 10% of control value, as well as immediate and long-term animal survival, were noted. The dBcAMP was administered at the end of the hypoxic insult. Treated animals recovered the evoked response earlier than the untreated controls and had better immediate and long-term survival rates. ...
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AIMS: Ca2+ and cAMP are important intracellular modulators. In order to generate intracellular signals with various amplitudes, as well as different temporal and spatial properties, a tightly and precise control of these modulators in intracellular compartments is necessary. The aim of this study was to evaluate the effects of elevated and sustained cAMP levels on voltage-dependent Ca2+ currents and proliferation in pituitary tumor GH3 cells. MAIN METHODS: Effect of long-term exposure to forskolin and dibutyryl-cyclic AMP (dbcAMP) on Ca2+ current density and cell proliferation rate were determined by using the whole-cell patch-clamp technique and real time cell monitoring system. The cAMP levels were assayed, after exposing transfected GH3 cells with the EPAC-1 cAMP sensor to forskolin and dbcAMP, by FRET analysis. KEY FINDINGS: Sustained forskolin treatment (24 and 48h) induced a significant increase in total Ca2+ current density in GH3 cells. Accordingly, dibutyryl-cAMP incubation (dbcAMP) also
I need to find: Histochemical Journal 32(10):581-90,2000 Oct. Title of the article is The effect of dibutyryl cyclic AMP on the expression of actin isoforms in astroglia. Does anyone out there in Histo Land have this or could point me to a good source? Thanks in advance, Carol Ann Bobrowitz Histology Core Laboratory Department of Physiology Medical College of Wisconsin Milwaukee, Wisconsin (414) 456-8179 FAX (414) 456-6546 [email protected] ...
Bucladesine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bucladesine is available on the Drugs.com website.
TY - JOUR. T1 - Protein phosphorylation in primary astrocyte cultures treated with and without dibutyryl cyclic AMP. AU - Neary, Joseph T.. AU - Gutierrez, Maria del Pilar. AU - Norenberg, Luz Oliva B.. AU - Norenberg, Michael D.. PY - 1987/4/28. Y1 - 1987/4/28. N2 - Protein phosphorylation was investigated in primary rat astrocyte cultures treated with and without dibutyryl cyclic AMP. Astrocytes maintained in dibutyryl cyclic AMP for several weeks displayed increased phosphate incorporation in 5 protein bands (55, 52, 45, 43 and 28 kDa) while incorporation in one band (42 kDa) was decreased. Phosphate incorporation in several other protein bands was unchanged. Calcium-dependent phosphate incorporation was also altered by prior exposure of the cells to dibutyryl cyclic AMP: addition of calcium to broken cell preparations resulted in increased incorporation in 75, 53 and 52 kDa while decreased incorporation occurred in 100 kDa. These differences in protein phosphorylation may be related to the ...
DYMPNA M. P. MORROW, MICHAEL P. RYAN, HUGH Mc GLYNN; Downregulation of intracellular cyclic AMP levels by tumour promoting agents. Biochem Soc Trans 1 February 1997; 25 (1): 148S. doi: https://doi.org/10.1042/bst025148s. Download citation file:. ...
Glial fibrillary acidic protein (GFA) expression was induced in rat C6 glioma in chemically defined medium by the addition of N6,O2-dibutyryl cyclic AMP (dbcAMP). Induction was dependent on the increase in intracellular cyclic AMP (cAMP), which was linearly correlated with added dbcAMP. Contrary to GFA mRNA synthesis, which can be obtained by cAMP-dependent and -independent pathways, translation of mRNA into GFA was observed only above a cellular cAMP concentration of approximately 0.2 fmol/cell. dbcAMP stimulation did not affect the vimentin concentration, which remained at a low level, but changed the cellular morphology from a bipolar to a stellate shape. A similar morphological change was observed after stimulation of C6 with lipopolysaccharide (LPS). However, LPS did not significantly increase the intracellular concentration of cAMP and the LPS-induced mRNA was not translated into GFA. Our results indicate that GFA synthesis is regulated at the mRNA level and at the translational level and ...
1. Cyclic AMP-stimulated protein kinase activity phosphorylating intrinsic substrates in preparations of synaptic-membrane fragments from ox cerebral cortex was examined in relation to (a) the content of membrane-bound Ca2+in the preparations and (b) added Ca2+in the assay medium. 2. Centrifugal washing of synaptic-membrane fragments with buffered ethane dioxybis(ethylamine)tetra-acetate solutions decreased bound Ca2+from 2.8±0.4 (s.d.) to 0.9±0.3nmol/mg of protein. In washed preparations basal protein kinase activity was increased by about 40% and the cyclic AMP-stimulated activity by about 15%. Addition of Ca2+in the concentration range 5-50μm to the assay medium progressively inhibited the kinase activity of the washed preparations; in this range of Ca2+concentration the basal activity was inhibited more than the stimulated activity. 3. In unwashed preparations concentrations of Ca2+above 100μm inhibited the cyclic AMP-stimulated activity more than the basal activity. 4. The inhibitory ...
Innovative genomic test for bucladesine personalised pharmacogenomic analysis to explore how your genes can affect and modulate your response to bucladesine ...
The detector detects the ion as it creates an electric current as it attracts electrons. This creates a mass spectra showing the mass to charge ratio (m/z). This shows the abundance of each isotope. There are also ghost results - this is when a +2 ion is detected and due to its higher charge this means it is much lower than the other detections ...
TY - JOUR. T1 - Immunocytochemical expression of human muscle cell p75 neurotrophin receptor is down-regulated by cyclic adenosine 3,5-monophosphate. AU - Baron, Pierluigi. AU - Scarpini, Elio. AU - Pizzul, Silvia. AU - Zotti, Fabrizio. AU - Conti, Giancarlo. AU - Pleasure, David E. AU - Scarlato, Guglielmo. PY - 1997/10/3. Y1 - 1997/10/3. N2 - To investigate whether the immunocytochemical expression of low affinity neurotrophin receptor (p75) in human muscle is modulated by increased levels of intracellular cyclic adenosine 3,5-monophoshate (cAMP), human cultured myogenic cells were treated with cAMP analogues dibutyryl cAMP (dbcAMP 0.5-1 mM) and 8-bromo cAMP (1 mM) or the adenylate cyclase activator forskolin (10- 100 μM). Cultures were processed for indirect immunofluorescence microscopy using an anti-human p75 mAb. The treatment of cultured muscle cells with cAMP analogues or forskolin for two days induced a decrease of immunoreactivity for p75 and a reduction of both myotube formation ...
TY - JOUR. T1 - Contribution of stored rat growth hormone to restoration of depleted rat pituitary immediate release pools. AU - Stachura, M. E.. AU - Tyler, J. M.. PY - 1990/1/1. Y1 - 1990/1/1. N2 - Stored rat pituitary growth hormone (GH) is functionally divided into immediately releasable and more stable compartments. These observations are consistent with either intracellular hormone compartmentalization within cells of a functionally homogeneous somatotroph population or summed responses from a heterogeneous population of functionally specialized cell subgroups. We investigated the pituitarys ability to recruit stored rGH to replenish depleted immediate release pools. We used perifused pituitary fragments whose stored rGH was labeled during pre-incubation in the presence of [3H] leucine. Initial immediate release pool depletion was accomplished by continuous exposure to combined 21 mM potassium ion (K+) and 1 mM dibutyryl cyclic AMP (dbcAMP). During a subsequent perifusion period in the ...
Juurlink, B H.; Hertz, L; and Fedoroff, S, Effects of high serum levels, dibutyryl cyclic amp and hydrocortisone on glutamine synthetase activity in primary mouse astroglial cultures. Abstr. (1979). Subject Strain Bibliography 1979. 1485 ...
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an enzyme that phosphorylates target proteins in response to a rise in intracellular cyclic AMP. See cyclic AMP‐dependent protein
Looking for online definition of cyclic adenosine monophosphate (cyclic AMP, cAMP, 3',5'-cAMP) in the Medical Dictionary? cyclic adenosine monophosphate (cyclic AMP, cAMP, 3',5'-cAMP) explanation free. What is cyclic adenosine monophosphate (cyclic AMP, cAMP, 3',5'-cAMP)? Meaning of cyclic adenosine monophosphate (cyclic AMP, cAMP, 3',5'-cAMP) medical term. What does cyclic adenosine monophosphate (cyclic AMP, cAMP, 3',5'-cAMP) mean?
To test whether angiotensinogen might be targeted to dense core secretory granules in cells containing a regulated secretory pathway, we expressed rat angiotensinogen in AtT-20 cells, a mouse pituitary cell line that has the demonstrated ability to correctly sort proteins to the constitutive or regulated pathway. We compared the pattern of secretion of angiotensinogen with that of endogenous adrenocorticotropin hormone, which is secreted by AtT-20 cells through the regulated pathway. When cells were incubated for 5 hours with dibutyryladenosine cyclic monophosphate or KCl, adrenocorticotropin hormone secretion was significantly higher than control, whereas monensin had no effect. In contrast, angiotensinogen secretion was markedly reduced by monensin, but no stimulation was observed with dibutyryladenosine cyclic monophosphate or KCl. These results make it unlikely that angiotensinogen could be cotargeted with active renin in the dense core granules of the regulated pathway. Alternative ...
Induction of neural differentiation in cultures of undetermined presumptive epidermis from three amphibian species was achieved by the addition of 1 millimolar dibutyryl adenosine 3,5-monophosphate, 8-bromadenosine 3,5-monophosphate, or adenosine C,E-monophosphate together with theophylline. Adenosine 5-monophosphate, adenosine 2,3-monophosphate, dibutyryl guanosine 3,5-monophosphate, and butyrate at 1 millimolar are ineffective. These results suggest that the action of the primary inductor or inductors may be mediated via adenosine 3,5-monophosphate. ...
Both treatments resulted in improvements in lung function that were sustained throughout the study. As compared with treatment with high-dose budesonide, treatment with low-dose budesonide plus theophylline resulted in greater improvements in forced
ค่ายนี้เป็นค่ายระดับมัธยมศึกษา สำหรับเยาวชนที่สนใจการศึกษาต่อในสาขาชีวเคมี. จัดขึ้นเป็นครั้งแรกเมื่อเดือนมกราคม 2558 โดยนิสิตภาควิชาชีวเคมี คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย. ชมมิวสิควิดิโอ What is the pathway? ซึ่งจัดทำขึ้นโดยนิสิตภาควิชาชีวเคมี คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย. ...
Available data indicate that the liver is a target organ for parathyroid hormone (PTH) and that this effect is most likely mediated by PTH-induced calcium entry into hepatocytes. The present study examined the effects of both PTH-(1-84) and its amino-terminal fragment [PTH-(1-34)] on cytosolic calcium concentration ([Ca2+]i) of hepatocytes and explored the cellular pathways that mediate this potential action of PTH. Both moieties of PTH produced a dose-dependent rise in [Ca2+]i, but the effect of PTH-(1-84) was greater (P | 0.01) than an equimolar amount of PTH-(1-34). This effect required calcium in the medium and was totally [PTH-(1-34)] or partially [PTH-(1-84)] blocked by PTH antagonist ([Nle8,18,Tyr34]bPTH-(7-34)-NH2] and by verapamil or nifedipine. Sodium or chloride channel blockers did not modify this effect. 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C, dibutyryl adenosine 3,5-cyclic monophosphate (DBcAMP), and G protein activator also produced a dose-dependent
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The kinetics for activation of the cyclic adenosine 3′:5′-monophosphate (cyclic AMP)-dependent protein kinase (PKA) and thymidine incorporation into DNA was investigated in epinephrine- and prostaglandin E1 (PGE1)-treated murine P1798 lymphosarcoma cells. A positive correlation between the duration and extent of PKA activation and Accumulation of cyclic AMP and inhibition of thymidine incorporation into DNA was observed with both hormones. Epinephrine and PGE1 elevated intracellular cyclic AMP 34- and 14-fold, respectively. All hormone concentrations which increased cyclic AMP accumulation also promoted inhibition of thymidine incorporation into DNA. In addition, dibutyryl cyclic AMP (50 µm) inhibited thymidine incorporation.. No difference in the kinetics for activation of PKA was observed when cells were treated with µm epinephrine or PGE1. With both agents, 50% PKA activation was observed when intracellular cyclic AMP concentrations were elevated 6.5-fold, or to 9 pmol/106 cells. In the ...
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Cyclic 3,5-adenosine monophosphate modulates vascular endothelial cell migration in vitro.: Using a modified Boyden chamber assay, we have examined the effect
15731-72-3 - UEUPTUCWIHOIMK-RRKCRQDMSA-N - 2-Deoxy-3-adenosine monophosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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Synaptic-membrane fragments from ox cerebral cortex contain basal and cyclic AMP-stimulated protein kinase activity catalysing the phosphorylation of endogenous substrates. Extraction of membrane fragments with Triton X-100 solubilized less than 20% of the kinase activity and left the major part of the endogenous substrates in the insoluble fraction.. ...
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Gandelman, K.Y., S.E. Pfeiffer, and J.H. Carson. Cyclic AMP regulation of P0 glycoprotein and myelin basic protein gene expression in semi-differentiated peripheral neurinoma cell line D6P2T. Development 106.2 (1989): 389-398. Web. 05 April. 2020. ...
Background: Previously weve found out that the decline in β2-adrenoreceptors (β2-AR) function affects airway response to cold air.. Objective: The aim of our study was to reveal the contribution of Arg16Gly SNP (rs1042713) in the development of cold airway hyperresponsiveness (CAHR) in asthmatics.. Methods: The study included examination of 60 mild to moderate asthmatics of Caucasian race, mostly non-smokers (mean age 36±1.39). All the patients underwent spirometry before and after the challenge with 3-minute isocapnic (5% CO2) cold air (-20°C) hyperventilation (ICAH). More than 10% drop in FEV1 was interpreted as a positive result. Intracellular cyclic adenosine monophosphate (cAMP) concentration in lymphocytes was measured before and 30 min after ICAH under in vitro stimulation with 10-6M epinephrine. PCR-RFLP analysis was used for genotyping.. Results: Arg16Arg genotype dominated in the group with CAHR (χ2=7.47; p=0.02). Mean FEV1 drop differed between homozygous patients (16.03±2.07 ...
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bucladesine (dibutyryl cAMP, db cAMP) - also a phosphodiesterase inhibitor pertussis toxin, which increases cAMP levels by ...
... dihydrate Amipizone Apremilast Arofylline Atizoram Befuraline Bemarinone hydrochloride Bemoradan Benafentrine Bucladesine ...
... bucladesine (INN) Bucladin-S buclizine (INN) buclosamide (INN) bucloxic acid (INN) bucolome (INN) bucricaine (INN) bucrilate ( ...
... bucladesine MeSH D13.695.462.250 - cyclic cmp MeSH D13.695.462.275 - cyclic gmp MeSH D13.695.462.275.325 - dibutyryl cyclic gmp ... bucladesine MeSH D13.695.827.068.506 - flavin-adenine dinucleotide MeSH D13.695.827.068.694 - nad MeSH D13.695.827.068.749 - ... bucladesine MeSH D13.695.667.138.410 - deoxyadenine nucleotides MeSH D13.695.667.138.506 - flavin-adenine dinucleotide MeSH ...
... (trade names Daxas, Daliresp) is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as chronic obstructive pulmonary disease (COPD).[5][6][7][8] In June 2010, it was approved in the EU for severe COPD associated with chronic bronchitis.[9] In March 2011, it gained FDA approval in the US for reducing COPD exacerbations.[10] ...
... is not produced by plants[citation needed] and is only observed in nature as a metabolite of caffeine in animals. Paraxanthine is also a natural metabolite of caffeine in some species of bacteria.[1] After intake, roughly 84% of caffeine is demethylated at the 3-position to yield paraxanthine, making it the chief metabolite of caffeine in the body.[2] Paraxanthine is also a major metabolite of caffeine in humans and other animals, such as mice.[3] Shortly after ingestion, caffeine is metabolized into paraxanthine by hepatic cytochrome P450,[4] which removes a methyl group from the N3 position of caffeine.[5] After formation, paraxanthine can be broken down to 7-methylxanthine by demethylation of the N1 position,[6] which is subsequently demethylated into xanthine or oxidized by CYP2A6 and CYP1A2 into 1,7-dimethylaric acid.[5] In another pathway, paraxanthine is broken down into 5-acetylamino-6-formylamino-3-methyluracil through N-acetyl-transferase 2, which is then broken down into ...
Molostvov G, Morris A, Rose P, Basu S, Muller G (February 2004). "The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures". British Journal of Haematology. 124 (3): 366-75. doi:10.1046/j.1365-2141.2003.04777.x. PMID 14717786 ...
... has been shown to inhibit TGF-beta-mediated conversion of pulmonary fibroblasts into myofibroblasts in COPD and asthma via cAMP-PKA pathway and suppresses COL1 mRNA, which codes for the protein collagen.[24] It has been shown that theophylline may reverse the clinical observations of steroid insensitivity in patients with COPD and asthmatics who are active smokers (a condition resulting in oxidative stress) via a distinctly separate mechanism. Theophylline in vitro can restore the reduced HDAC (histone deacetylase) activity that is induced by oxidative stress (i.e., in smokers), returning steroid responsiveness toward normal.[25] Furthermore, theophylline has been shown to directly activate HDAC2.[25] (Corticosteroids switch off the inflammatory response by blocking the expression of inflammatory mediators through deacetylation of histones, an effect mediated via histone deacetylase-2 (HDAC2). Once deacetylated, DNA is repackaged so that the promoter regions of inflammatory genes ...
Reports of recreational use of glaucine have recently been published, and effects include dissociative-type symptoms; feeling detached and 'in another world', as well as nausea, vomiting and dilated pupils. These reports mirror those about the effects of clinical use, which state dissociative-type symptoms as well as lethargy, fatigue, hallucinations.[8][9] Investigation of side effects in a clinical setting also reports that the hallucinatory effects manifest as bright and colorful visualizations. They also report that patients perceive their environments clearly yet feel detached from it; "the patient sees and understands everything and is oriented well enough, but cannot take a clear and adequate action".[8]. One particular report of recreational use gone awry described the form of distribution as tablets being marketed as a 1-benzylpiperazine (BZP)-free "herbal high" which the patient referred to as "head candy".[9]. ...
The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side-effect is nausea; the infrequent side effects are abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial edema, hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism. One possibly serious, but rare, side effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated.[4] On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of vardenafil, and other PDE5 inhibitors.[5] ...
Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology. 22 (5): 395-402. doi:10.1007/bf00542541. PMID 6288396 ...
Animals that metabolize theobromine (found in chocolate) more slowly, such as dogs,[26] can succumb to theobromine poisoning from as little as 50 grams (1.8 oz) of milk chocolate for a smaller dog and 400 grams (14 oz), or around nine 44-gram (1.55 oz) small milk chocolate bars, for an average-sized dog. The concentration of theobromine in dark chocolates (approximately 10 g/kg (0.16 oz/lb)) is up to 10 times that of milk chocolate (1 to 5 g/kg (0.016 to 0.080 oz/lb)) - meaning dark chocolate is far more toxic to dogs per unit weight or volume than milk chocolate. The same risk is reported for cats as well,[27] although cats are less likely to ingest sweet food, with most cats having no sweet taste receptors.[28] Complications include digestive issues, dehydration, excitability, and a slow heart rate. Later stages of theobromine poisoning include epileptic-like seizures and death. If caught early on, theobromine poisoning is treatable.[29] Although not common, the effects of theobromine ...
The FDA's approval of sildenafil in 1998[16] was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Subsequently, the FDA approved vardenafil in 2003,[17] and tadalafil in 2003. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Tadalafil was approved in 2009 in the United States for the treatment of pulmonary arterial hypertension[18] and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Tadalafil was discovered by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs that began in August 1991.[19][20] In 1993, the Bothell, Washington biotechnology ...
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Kindling models in rats has shown vinpocetine to exhibit anticonvulsant properties. The most pronounced anticonvulsant effects were observed in Pentylenetetrazole (PTZ)-kindled rats although there was also an effect on amygdala-kindled and neocortically-kindled rats.[8] Vinpocetine has also been shown to abolish [3H]Glu release after in vivo exposure to 4-aminopyridine (4-AP) which suggests an important mechanism for vinpocetine anticonvulsant activity.[9] Vinpocetine has been investigated in animal models as a potential anti-inflammatory agent.[10] [11] Vinpocetine inhibits the up-regulation of NF-κB by TNFα in various cell tests. Reverse transcription polymerase chain reaction also shows that it reduced the TNFα-induced expression of the mRNA of proinflammatory molecules such as interleukin-1 beta, monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1). In mice, vinpocetine reduced lipopolysaccharide inoculation induced polymorphonuclear neutrophil ...
A list of US medications equivalent to Bucladesine is available on the Drugs.com website. ... Bucladesine is a medicine available in a number of countries worldwide. ...
Ca(2+) channels, Cell proliferation, FRET-imaging, Forskolin, Patch-clamp, cAMP, Animals, Bucladesine, Calcium Channel Blockers ...
... , Sodium salt,DC-2797,Actosin,Barium salt,Bucladesine, Barium salt ... Bucladesine,N-(1-Oxobutyl)adenosine cyclic 3,5-(hydrogen phosphate) 2-butanoate,N-(9-beta-D-ribofuranosyl-9H-purin-6-yl) ...
... personalised pharmacogenomic analysis to explore how your genes can affect and modulate your response to bucladesine ... ... Knowing the optimal dose of bucladesine to treat your medical condition, and whether bucladesine is safe to treat your medical ... Can the treatment to your medical condition with bucladesine pose a safety concern to your health because of your genetic ... What is the optimal medicament dose of bucladesine to treat your medical condition in line with your genomic makeup? ...
"Bucladesine" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Bucladesine" by people in this website by year, and whether " ... Below are the most recent publications written about "Bucladesine" by people in Profiles. ...
Bucladesine / pharmacology * Calcium / metabolism * Cells, Cultured * Cyclic AMP / metabolism * Dexamethasone / pharmacology* * ...
bucladesine (dibutyryl cAMP, db cAMP) - also a phosphodiesterase inhibitor. *pertussis toxin, which increases cAMP levels by ...
Bucladesine [INN] View Synonyms. View Structure. Description:. A cyclic nucleotide derivative that mimics the action of ...
Bucladesine / metabolism. Carbon Radioisotopes / metabolism. Enzyme Inhibitors / pharmacology. Gastric Acid / secretion*. ... 362-74-3/Bucladesine; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-45-6/Histamine; 58-15-1/Aminopyrine; 74-79-3/Arginine; 79032 ...
Bucladesine / pharmacology. Culture Media. Culture Techniques*. Dissection*. Drug Synergism. Female. Glucose / pharmacology. ... 0/Culture Media; 10238-21-8/Glyburide; 11061-68-0/Insulin; 362-74-3/Bucladesine; 50-99-7/Glucose; 58-55-9/Theophylline; 61-90-5 ...
Amrinone • Milrinone • Enoximone • Bucladesine. Other cardiac stimulants. Angiotensinamide • Xamoterol • Levosimendan. Category ...
Internal Search Keywords: Dibutyryl-cAMP,16980-89-5,73884,PKA Inhibitor,DC 2797,Bucladesine,73882 ...
bucladesine affects expression. ISO. RGD:1348976. 6480464. Bucladesine affects the expression of SOX1 mRNA, Bucladesine affects ... bucladesine multiple interactions. ISO. RGD:1348976. 6480464. bisphenol A affects the reaction [Bucladesine affects the ... Paraquat affects the reaction [Bucladesine affects the expression of SOX1 mRNA], Paraquat affects the reaction [Bucladesine ... bisphenol A affects the reaction [Bucladesine affects the expression of SOX1 mRNA] more .... CTD. PMID:27271280, PMID:31400064 ...
Phosphodiesterase Inhibitors Overview (PDE3I) , Amrinone , Milrinone , Enoximone , Bucladesine Other cardiac stimulants , ...
Dibutyryl-cAMP (Bucladesine) New Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of ...
Dibutyryl-cAMP (Bucladesine) New Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of ...
PeproTech the producer of high quality recombinant cytokines and growth factors supports life science research, cellular therapy and regenerative medicine.
Zinc Chloride and Lead Acetate-Induced Passive Avoidance Memory Retention Deficits Reversed by Nicotine and Bucladesine in Mice ... The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in ... Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial ...
Bucladesine/pharmacology. *Carcinoma, Hepatocellular. *Cell Membrane/metabolism. *Dithionite/pharmacology. *Fluorescent Dyes. * ...
... dihydrate Amipizone Apremilast Arofylline Atizoram Befuraline Bemarinone hydrochloride Bemoradan Benafentrine Bucladesine ...
Bucladesine (sodium salt) Bucladesine (calcium salt) SU6656 Altiratinib AZ-5104 Trapidil Chloropyramine hydrochloride Empty. ...
Bucladesine (calcium salt) PF-3084014 SIS3 Bucladesine (sodium salt) MK-4101 VX-11e Tofacitinib (citrate) Empty. ...
Bucladesine/pharmacology. MESH. Calcitriol/pharmacology. MESH. Cell Differentiation. MESH. Dimethyl Sulfoxide/pharmacology. ...
Bucladesine/pharmacology. MESH. Calcitriol/pharmacology. MESH. Canavanine/pharmacology. MESH. Cell Line. MESH. ...
Bucladesine sodium. X5982. Calcium dibutyryladenosine cyclophosphate. E997. Cladribine. G787. Clofarabine. J53527. Clofarabine ... Bucladesine sodium. X5982. Calcium dibutyryladenosine cyclophosphate. C994. Cytidine-5-diphosphate. E287. Cytidine-5- ...
Bucladesine Medicine & Life Sciences * Hepatocytes Medicine & Life Sciences * Adenosine Monophosphate Medicine & Life Sciences ...
14-3-3 Proteins; Amino Acid Sequence; Animals; Binding Sites; Bucladesine; Calcineurin; Calcium; *Calcium Signaling; Cell Line ...
Affinity Labels; Animals; Animals, Newborn; Astrocytes; Binding Sites; Brain; Bucladesine; Catalysis; Cells, Cultured; ...
TY - JOUR. T1 - Efflux in isolated hepatocytes as a possible correlate of secretion in, vivo. T2 - Induced exit of the folic acid analog methotrexate, by dibutyryl cyclic AMP or isobutyl methyl xanthine. AU - Gewirtz, David A.. AU - Randolph, Joyce K.. AU - Goldman, I. David. PY - 1981/7/30. Y1 - 1981/7/30. N2 - Dibutyryl cyclic AMP and isobutyl methyl xanthine induce release of freely exchangeable methotrexate as well as a small component of apparently bound drug from freshly isolated rat hepatocytes; methotrexate polyglutamate derivatives are retained. These observations, as well as the energy dependence of methotrexate efflux induced by dibutyryl cyclic AMP suggests that this may represent the induction of a "secretory" phenomenon in which drug is released into the capillary sinusoid and/or the bile canaliculus when the hepatocyte is in its normal spatial orientation in the liver lobule in, vivo. Because there is ...
Bucladesine Medicine & Life Sciences * Inferior Colliculi Medicine & Life Sciences * Epilepsy Medicine & Life Sciences ...
  • Bucladesine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. (mark-e-murphy.com)
  • en] Modifications of cell shape induced in cultured newborn rat astroblasts by serum deprivation or dibutyryladenosine 3'-5' monophosphate (dBcAMP) are described. (uliege.be)
  • This graph shows the total number of publications written about "Bucladesine" by people in this website by year, and whether "Bucladesine" was a major or minor topic of these publications. (rush.edu)