Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Electric Countershock: An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Cardiopulmonary Resuscitation: The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Electrophysiologic Techniques, Cardiac: Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Defibrillators: Cardiac electrical stimulators that apply brief high-voltage electroshocks to the HEART. These stimulators are used to restore normal rhythm and contractile function in hearts of patients who are experiencing VENTRICULAR FIBRILLATION or ventricular tachycardia (TACHYCARDIA, VENTRICULAR) that is not accompanied by a palpable PULSE. Some defibrillators may also be used to correct certain noncritical dysrhythmias (called synchronized defibrillation or CARDIOVERSION), using relatively low-level discharges synchronized to the patient's ECG waveform. (UMDNS, 2003)Ajmaline: An alkaloid found in the root of RAUWOLFIA SERPENTINA, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.Bundle-Branch Block: A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Syndrome: A characteristic symptom complex.Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Body Surface Potential Mapping: Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Refractory Period, Electrophysiological: The period of time following the triggering of an ACTION POTENTIAL when the CELL MEMBRANE has changed to an unexcitable state and is gradually restored to the resting (excitable) state. During the absolute refractory period no other stimulus can trigger a response. This is followed by the relative refractory period during which the cell gradually becomes more excitable and the stronger impulse that is required to illicit a response gradually lessens to that required during the resting state.Cardiac Complexes, Premature: A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.Resuscitation: The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)Sodium Channels: Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Pericardium: A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Endocardium: The innermost layer of the heart, comprised of endothelial cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Pulmonary Veins: The veins that return the oxygenated blood from the lungs to the left atrium of the heart.Heart Massage: Rhythmic compression of the heart by pressure applied manually over the sternum (closed heart massage) or directly to the heart through an opening in the chest wall (open heart massage). It is done to reinstate and maintain circulation. (Dorland, 28th ed)Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Heart: The hollow, muscular organ that maintains the circulation of the blood.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Atrial Flutter: Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).Out-of-Hospital Cardiac Arrest: Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.Sodium Channel Blockers: A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.Recurrence: The return of a sign, symptom, or disease after a remission.Ventricular Premature Complexes: A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Anticoagulants: Agents that prevent clotting.Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Propafenone: An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.Epicardial Mapping: Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Emergency Medical Services: Services specifically designed, staffed, and equipped for the emergency care of patients.Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Voltage-Sensitive Dye Imaging: Optical imaging techniques used for recording patterns of electrical activity in tissues by monitoring transmembrane potentials via FLUORESCENCE imaging with voltage-sensitive fluorescent dyes.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.NAV1.5 Voltage-Gated Sodium Channel: A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.Atrial Appendage: Ear-shaped appendage of either atrium of the heart. (Dorland, 28th ed)Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Cardiac Electrophysiology: The study of the electrical activity and characteristics of the HEART; MYOCARDIUM; and CARDIOMYOCYTES.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Hypothermia, Induced: Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.Wolff-Parkinson-White Syndrome: A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.Myocardial Reperfusion Injury: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Sick Sinus Syndrome: A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Fourier Analysis: Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)Electric Injuries: Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Perfusion: Treatment process involving the injection of fluid into an organ or tissue.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)Arrhythmogenic Right Ventricular Dysplasia: A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.Purkinje Fibers: Modified cardiac muscle fibers composing the terminal portion of the heart conduction system.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Ventricular Function: The hemodynamic and electrophysiological action of the HEART VENTRICLES.Commotio Cordis: A sudden CARDIAC ARRHYTHMIA (e.g., VENTRICULAR FIBRILLATION) caused by a blunt, non-penetrating impact to the precordial region of chest wall. Commotio cordis often results in sudden death without prompt cardiopulmonary defibrillation.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Vagus Nerve Stimulation: An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.Tachycardia, Supraventricular: A generic expression for any tachycardia that originates above the BUNDLE OF HIS.Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.Equipment Failure: Failure of equipment to perform to standard. The failure may be due to defects or improper use.Digitalis Glycosides: Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Bretylium CompoundsTachycardia, Paroxysmal: Abnormally rapid heartbeats with sudden onset and cessation.Atrial Function: The hemodynamic and electrophysiological action of the HEART ATRIA.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Atrial Function, Left: The hemodynamic and electrophysiological action of the LEFT ATRIUM.Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Ergonovine: An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Atrial Premature Complexes: A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites. The ectopic signals may or may not conduct to the HEART VENTRICLES. Atrial premature complexes are characterized by premature P waves on ECG which are different in configuration from the P waves generated by the normal pacemaker complex in the SINOATRIAL NODE.Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.Myocardial Reperfusion: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Tocainide: An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Voltage-Gated Sodium Channel beta-1 Subunit: A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Papillary Muscles: Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.Voltage-Gated Sodium Channel beta-3 Subunit: A voltage-gated sodium channel beta subunit subtype that non-covalently associates with voltage-gated alpha subunits. Defects in the SCN3B gene which codes for this beta subunit are associated with Brugada syndrome 7.Cardiac Surgical Procedures: Surgery performed on the heart.beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.Ambulances: A vehicle equipped for transporting patients in need of emergency care.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.Equipment Design: Methods of creating machines and devices.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Optics and Photonics: A specialized field of physics and engineering involved in studying the behavior and properties of light and the technology of analyzing, generating, transmitting, and manipulating ELECTROMAGNETIC RADIATION in the visible, infrared, and ultraviolet range.Coronary Vessels: The veins and arteries of the HEART.Sydnones: OXADIAZOLES bearing an oxygen at the 5-position. They are mesoionic, with delocalized positive and negative charges.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Stellate Ganglion: A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.Atrioventricular Node: A small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart.Coronary Care Units: The hospital unit in which patients with acute cardiac disorders receive intensive care.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Electrodes, Implanted: Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.Torsades de Pointes: A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Emergency Medical Technicians: Paramedical personnel trained to provide basic emergency care and life support under the supervision of physicians and/or nurses. These services may be carried out at the site of the emergency, in the ambulance, or in a health care institution.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.JapanInternational Normalized Ratio: System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.Embolism: Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.Sus scrofa: A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.Aconitine: A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.Echocardiography, Transesophageal: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Amplifiers, Electronic: Electronic devices that increase the magnitude of a signal's power level or current.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Bethanidine: A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.Canrenone: A synthetic pregnadiene compound with anti-aldosterone activity.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Cryosurgery: The use of freezing as a special surgical technique to destroy or excise tissue.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Atrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Electrophysiological Phenomena: The electrical properties, characteristics of living organisms, and the processes of organisms or their parts that are involved in generating and responding to electrical charges.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Methylguanidine: A product of putrefaction. Poisonous.Differential Threshold: The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Ventricular Dysfunction, Right: A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.Heart Arrest, Induced: A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Blood Circulation: The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.Ventricular Function, Right: The hemodynamic and electrophysiological action of the right HEART VENTRICLE.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Jervell-Lange Nielsen Syndrome: A form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the VOLTAGE-GATED POTASSIUM CHANNEL. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Diacetyl: Carrier of aroma of butter, vinegar, coffee, and other foods.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Monitoring, Physiologic: The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Myocardial Stunning: Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Tachycardia, Ectopic Atrial: Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.
Brugada syndrome can result in ventricular fibrillation and potentially death. It is a major cause of sudden unexpected cardiac ... Brugada syndrome is a genetic disease that result in mutations in the sodium ion channel (gene SCN5A) of the myocytes in the ... It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome. The compound ... Ajmaline is used intravenously to test for Brugada syndrome since they both affect the sodium ion channel. In an afflicted ...
... variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation". Circulation: Arrhythmia and ... Inherited sequence variants in human KCNE5 are associated with atrial fibrillation and Brugada syndrome. Atrial fibrillation is ... Brugada syndrome is a relatively rare but lethal ventricular arrhythmia most commonly linked to voltage-gated sodium channel ... giving a possible mechanism for Brugada syndrome, i.e., increased ventricular Ito density. A KCNE5 non-coding region gene ...
... idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage". J Electrocardiol 38 (4 Suppl): ... Antzelevitch C, Brugada P, Brugada J, Brugada R, Towbin JA, Nademanee K (2003). "Brugada syndrome: 1992-2002: a historical ... Yan also published studies on the cellular basis of Brugada syndrome, potential linkages between Brugada and ERS, arrhythmic ... and the conditions during myocardial ischemia that can initiate phase 2 reentry and then produce ventricular fibrillation. ...
List of circulatory system conditions
... fibrillation Atrial fibrillation with rapid ventricular response Atrial flutter Atrial tachycardia Bifascicular block Brugada ... January 2004). "Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected ... Atrial septal defect Ventricular septal defect Patent ductus arteriosus and Coarctation of aorta (may cause cyanosis in some ... Catecholaminergic polymorphic ventricular tachycardia Ectopic beat (cardiac ectopy) Ectopic pacemaker (Ectopic focus) First- ...
Masonic Medical Research Laboratory
... to be linked to idiopathic ventricular fibrillation (IVF). The MMRL named this the Brugada syndrome in 1996, after Josep and ... Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical ... During the next few years MMRL discovered several genes that when mutated give rise to the Long QT, Short QT, Brugada and Early ... 31, 2015 "Brugada syndrome delved into in the New York Times". Medscape, Michael O'Riordan February 10, 2004 Inborn Genetic ...
The cause of sudden death in Brugada syndrome is ventricular fibrillation (VF). The average age of death is 41. According to ... Brugada syndrome: clinical and genetic findings. Sarquella-Brugada G1, Campuzano O2, Arbelo E3, Brugada J4, Brugada R5. Hedley ... Brugada J, Brugada P, Brugada R (July 1999). "The syndrome of right bundle branch block ST segment elevation in V1 to V3 and ... Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, ...
... can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, ... MacWilliam spent many years working on ventricular fibrillation and was one of the first to show that ventricular fibrillation ... on the basis of the fact that ventricular fibrillation itself is common, idiopathic ventricular fibrillation accounts for an ... of the cases of ventricular fibrillation unrelated to myocardial infarction, and 14% of all ventricular fibrillation ...
... often leading to ventricular fibrillation. This is a type of tachycardia that originates from above the ventricles, such as the ... Antiarrhythmic agents Anxiety Atrial fibrillation Atrial flutter Atrial tachycardia AV nodal reentrant tachycardia Brugada ... Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, narrow complex rhythm. ... Ventricular tachycardia (VT or V-tach) is a potentially life-threatening cardiac arrhythmia that originates in the ventricles. ...
Catecholaminergic polymorphic ventricular tachycardia
Ventricular tachycardia may self-terminate or degenerate into ventricular fibrillation, causing sudden death unless immediate ... Brugada syndrome Cardiac arrhythmia Long QT syndrome Sick sinus syndrome Sudden cardiac death Wehrens XH, Marks AR (November ... Lakatta, E. G.; Guarnieri T. (1993). "Spontaneous myocardial calcium oscillations: are they linked to ventricular fibrillation ... Catecholaminergic polymorphic ventricular tachycardia (CPVT), also called familial polymorphic ventricular tachycardia (FPVT) ...
The two shockable rhythms are ventricular fibrillation and pulseless ventricular tachycardia. In children 2 to 4 J/Kg is ... Examples of arrhythmic syndromes associated with SCD include: Long QT syndrome, Wolff-Parkinson-White Syndrome, Brugada ... The two "shockable" rhythms are ventricular fibrillation and pulseless ventricular tachycardia while the two "non-shockable" ... Neither lidocaine nor amiodarone, in those who continue in ventricular tachycardia or ventricular fibrillation despite ...
Brugada, and early repolarization syndromes, as well as the development of potential new treatments for atrial fibrillation (AF ... he demonstrated that quinidine could be used to treat ventricular tachycardia in experimental models of Brugada syndrome. In ... Antzelevitch C, Brugada P, Brugada J, Brugada R, Nademanee K, Towbin J (1999). The Brugada Syndrome. Armonk (NY): Futura. (Camm ... Antzelevitch C, Brugada P, Brugada J, Brugada R, Nademanee K, Towbin JA. The Brugada Syndrome. Armonk (NY): Futura Publishing; ...
Short QT syndrome
Management of atrial fibrillation
Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ, Damiano RJ Jr, Davies DW, Haines DE, Haissaguerre M, Iesaka Y, ... amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation". Crit. ... Oct 2010). "Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of ... Stroke Risk in Atrial Fibrillation Working Group (2007). "Independent predictors of stroke in patients with atrial fibrillation ...
... or left ventricular dysfunction) and also patients with ventricular arrhythmias, should not take this drug. The results were so ... In individuals suspected of having the Brugada syndrome, the administration of flecainide may help reveal the ECG findings that ... It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat ... The greatest effect is on the His-Purkinje system and ventricular myocardium. The effect of flecainide on the ventricular ...
Cardiac transient outward potassium current
An increase in the Ito1 density caused by a mutation in Kv4.3 can be a cause of Brugada Syndrome. Niwa, Noriko; Nerbonne, ... Brandt, M (October 2000). "The Ultrarapid and the Transient Outward K+Current in Human Atrial Fibrillation. Their Possible Role ... Beuckelmann, D. J.; Nabauer, M.; Erdmann, E. (1 August 1993). "Alterations of K+ currents in isolated human ventricular ... There is correlation between decreased Ito1 density and atrial fibrillation. ...
Fibrillation can affect the atrium (atrial fibrillation) or the ventricle (ventricular fibrillation): ventricular fibrillation ... Causes of SADS in young people include viral myocarditis, long QT syndrome, Brugada syndrome, Catecholaminergic polymorphic ... Ventricular arrhythmias include ventricular fibrillation and ventricular tachycardia. Arrhythmias are due to problems with the ... It is needed for the chaotic rhythm of ventricular fibrillation and is also used for pulseless ventricular tachycardia. Often, ...
... polymorphic ventricular tachycardia) Wide complex tachycardia Ventricular flutter Ventricular fibrillation Ventricular ... QT syndromes Brugada syndrome Short QT syndrome Long QT syndromes, genetic and drug-induced Right and left atrial abnormality ... must be specified as atrial or ventricular (e.g., the ventricular rate in ventricular fibrillation is 300-600 bpm, whereas the ... Jafary, Fahim H (2007). "The "incidental" episode of ventricular fibrillation: A case report". Journal of Medical Case Reports ...
Frank I. Marcus
... with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation or sustained ventricular ... arrhythmogenic right ventricular cardiomyopathy/dysplasia, and brugada syndrome". Journal of Electrocardiology. 33 Suppl: 1-10 ... The study aims to analyze diagnosis of patients and family members with right ventricular and left ventricular cardiomyopathy. ... Right ventricular volume analysis by angiography in right ventricular cardiomyopathy. The International Journal of ...
... may result in cardiac arrest and turn into ventricular fibrillation. Ventricular tachycardia is found ... Brugada P, Brugada J, Mont L, Smeets J, Andries EW (May 1991). "A new approach to the differential diagnosis of a regular ... Ventricular tachycardia may result in cardiac arrest and turn into ventricular fibrillation. Ventricular tachycardia can occur ... refers to the group of irregular heartbeats that includes ventricular tachycardia, ventricular fibrillation, and torsades de ...
Josep Brugada; Lluís Mont (2010). "Low efficacy of atrial fibrillation ablation in severe obstructive sleep apnea patients". ... and atrial tachycardia and ventricular tachycardia to identify targets for catheter ablation. In 2010, Dr. Sanjiv Narayan and ... Narayan SM; Krummen DE; Shivkumar K; Clopton P; Rappel WJ; Miller JM (12 August 2012). "Treatment of atrial fibrillation by the ... The data from the workstation is used to help diagnose the source of atrial fibrillation, atrial flutter, and atrial ...
... may result in cardiac arrest and turn into ventricular fibrillation. It is found initially in ... Brugada P, Brugada J, Mont L, Smeets J, Andries EW (May 1991). "A new approach to the differential diagnosis of a regular ... Ventricular tachycardia may result in cardiac arrest and turn into ventricular fibrillation. ... In this circumstance, it is best treated the same way as ventricular fibrillation (VF), and is recognized as one of the ...
... such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. Many attempts have been ... Brugada P (July 2000). "Magnesium: an antiarrhythmic drug, but only against very specific arrhythmias". Eur. Heart J. 21 (14): ... With regards to management of atrial fibrillation, classes I and III are used in rhythm control as medical cardioversion agents ... "protocol for management of haemodynamically stable ventricular tachycardia - General Practice Notebook". www.gpnotebook.co.uk. ...
... which can degenerate into ventricular fibrillation and sudden cardiac death. Moreover, KCNE2 gene variation can disrupt HCN1- ... "Long QT and Brugada syndrome gene mutations in New Zealand". Heart Rhythm. 4 (10): 1306-14. doi:10.1016/j.hrthm.2007.06.022. ... KCNE2 is required for Kv1.5 to localize to the intercalated discs of mouse ventricular myocytes. Kcne2 deletion in mice reduces ... This property means that many drugs or potential drugs have the capacity to impair human ventricular repolarization, leading to ...
... must be specified as atrial or ventricular (e.g., the ventricular rate in ventricular fibrillation is 300-600 bpm, whereas the ... ST elevation can also be caused by pericarditis, Brugada syndrome, or can be a normal variant (J-point elevation). ... Atrial fibrillation and atrial flutter without rapid ventricular response. *Premature atrial contraction (PACs) and premature ... episode of ventricular fibrillation: A case report". Journal of Medical Case Reports. 1: 72. doi:10.1186/1752-1947-1-72. PMC ...
... can degenerate into ventricular fibrillation, which is rapidly fatal without cardiopulmonary resuscitation (CPR) and ... and other electrical issue such as long QT syndrome and Brugada syndrome. Heart related causes also often have little history ... Ventricular tachycardia originate in the ventricles. VT causes syncope and can result in sudden death. Ventricular tachycardia ... However, while an ECG may identify conditions such as atrial fibrillation, heart block, or a new or old heart attack, it ...
List of OMIM disorder codes
TEK Ventricular fibrillation, familial, 1; 603829; SCN5A Ventricular fibrillation, paroxysmal familial, 2; 612956; DPP6 ... PLOD2 Brugada syndrome 1; 601144; SCN5A Brugada syndrome 2; 611777; GPD1L Brugada syndrome 3; 611875; CACNA1C Brugada syndrome ... 4; 611876; CACNB2 Brugada syndrome 5; 612838; SCN1B Brugada syndrome 6; 613119; KCNE3 Brugada syndrome 7; 613120; SCN3B Brugada ... TF Atrial fibrillation; 608583; GJA5 Atrial fibrillation, familial, 3; 607554; KCNQ1 Atrial fibrillation, familial, 4; 611493; ...
Other inherited heart conditions associated with the development of atrial fibrillation in children include Brugada syndrome, ... "Outcomes in atrial fibrillation patients with and without left ventricular hypertrophy when treated with a lenient rate-control ... Valvular atrial fibrillation refers to atrial fibrillation attributable to moderate to severe mitral valve stenosis or atrial ... There are multiple theories about the cause of atrial fibrillation. An important theory is that, in atrial fibrillation, the ...
... often leading to ventricular fibrillation. Supraventricular. Main article: Supraventricular tachycardia ... Ventricular. Main article: Ventricular tachycardia. Ventricular tachycardia (VT or V-tach) is a potentially life- ... Atrial fibrillation. Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, ... Atrial fibrillation. *Atrial flutter. *Atrial tachycardia. *AV nodal reentrant tachycardia. *Brugada syndrome ...
Wolf, RM; Glynn, P; Hashemi, S; Zarei, K; Mitchell, CC; Anderson, ME; Mohler, PJ; Hund, TJ (May 2013). "Atrial fibrillation and ... "Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of ... patients with ANK2 variants exhibited greater maximum left ventricular wall thickness. In patients with both ischemic and non- ... Robaei, D; Ford, T; Ooi, SY (February 2015). "Ankyrin-B syndrome: a case of sinus node dysfunction, atrial fibrillation and ...
Fibrillation can affect the atrium (atrial fibrillation) or the ventricle (ventricular fibrillation); ventricular fibrillation ... Causes of SADS in young people are long QT syndrome, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia ... Defibrillation differs in that it is used for ventricular fibrillation and pulseless ventricular tachycardia, and more ... Ventricular fibrillation occurs in the ventricles (lower chambers) of the heart; it is always a medical emergency. If left ...
... may result in ventricular fibrillation and turn into sudden death. It is found initially in about ... Brugada P, Brugada J, Mont L, Smeets J, Andries EW (May 1991). "A new approach to the differential diagnosis of a regular ... Ventricular tachycardia may result in cardiac arrest and turn into ventricular fibrillation. ... In this circumstance, it is best treated the same way as ventricular fibrillation (VF), and is recognized as one of the ...
Thyrotoxic periodic paralysis
Tricuspid valve stenosis
Fibrillation can affect the atrium (atrial fibrillation) or the ventricle (ventricular fibrillation): ventricular fibrillation ... Causes of SADS in young people include viral myocarditis, long QT syndrome, Brugada syndrome, Catecholaminergic polymorphic ... Ventricular arrhythmias include ventricular fibrillation and ventricular tachycardia. Arrhythmias are due to problems ... It is needed for the chaotic rhythm of ventricular fibrillation and is also used for pulseless ventricular tachycardia. Often, ...
Long QT syndrome
It is a relatively common cause of sudden death along with Brugada syndrome and arrhythmogenic right ventricular dysplasia. In ... Syncopal attacks due to paroxysmal ventricular fibrillation". Clin Pediatr (Bologna) (in Italian). 45: 656-83. PMID 14158288. ... "Ranolazine Safely Decreases Ventricular and Atrial Fibrillation in Timothy Syndrome (LQT8)". Pacing and Clinical ... In untreated individuals with JLNS, about 50% die by the age of 15 years due to ventricular arrhythmias. Romano-Ward syndrome ...
CS1 maint: Multiple names: authors list (link) Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ, Damiano RJ Jr, ... Israel C, Grönefeld G, Ehrlich J, Li Y, Hohnloser S (2004). "Long-term risk of recurrent atrial fibrillation as documented by ... Supraventricular Tachyarrhythmias in Cardiac Surgery in the Adult Cardiologic Interventional Therapy for Atrial and Ventricular ... A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of atrial fibrillation". Heart Rhythm. ...
Novel SCN5A mutation associated with idiopathic ventricular fibrillation due to subclinical Brugada syndrome |...
Idiopathic ventricular fibrillation can be caused by subclinical channelopathies such as Brugada syndrome. Our objective is to ... The D1816fs/g98747-98748insT mutation in SCN5A may be associated with idiopathic ventricular fibrillation and Brugada syndrome ... Novel SCN5A mutation associated with idiopathic ventricular fibrillation due to subclinical Brugada syndrome. Cardiogenetics, 2 ... Novel SCN5A mutation associated with idiopathic ventricular fibrillation due to subclinical Brugada syndrome https://doi.org/ ...
IMSEAR at SEARO: Ventricular Fibrillation with Brugada Syndrome: A Case Report.
Ventricular Fibrillation with Brugada Syndrome: A Case Report.. Authors: Nabi, Shaila. Tushar, Asif Zaman. Ferdaushi, Umme ... Ventricular Fibrillation with Brugada Syndrome: A Case Report. Cardiovascular Journal. 2015; 8(1): 69-72. ... Brugada syndrome is a potentially lethal and eminently treatable entity that may present with palpitations or syncope. This ... article presents the case of a young patient with Brugada syndrome and reviews key features in the epidemiology, ...
Brugada Syndrome in an Active Duty Air Force Senior Pilot - Redorbit
Idiopathic Ventricular Fibrillation Investigators. J Am Coll Cardiol 2001; 37: 1916-20. 10. Brugada J, Brugada P: Further ... Brugada P, Brugada R, Mont L, Rivero M, Geelen P, Brugada J: Natural history of Brugada syndrome: the prognostic value of ... Brugada P, Geelen P, Brugada R, Mont L, Brugada J: Prognostic value of electrophysiologic investigations in Brugada syndrome. J ... 3. Brugada P, Brugada R, Antzelevitch C, Brugada J: The Brugada syndrome. Arch Mal Coeur Vaiss 2005; 98: 115-22. ...
Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Parts I and II | Circulation
Idiopathic Ventricular Fibrillation and the Brugada Syndrome. Another interesting group of patients that has become a target ... Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang ... Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, Brugada J, Girona J, Domingo A, Bachinski LL, Roberts R ... Importantly, sudden cardiac death in FHCM is not necessarily caused by ventricular arrhythmias. Atrial fibrillation (Afib) in ...
Brugada syndrome: MedlinePlus Genetics
Brugada syndrome is a condition that causes a disruption of the hearts normal rhythm. Explore symptoms, inheritance, genetics ... idiopathic ventricular fibrillation, Brugada type. *Pokkuri death syndrome. *sudden unexpected nocturnal death syndrome ... Brugada R, Campuzano O, Sarquella-Brugada G, Brugada P, Brugada J, Hong K. Brugada Syndrome. 2005 Mar 31 [updated 2016 Nov 17 ... Brugada R, Campuzano O, Sarquella-Brugada G, Brugada J, Brugada P. Brugada syndrome. Methodist Debakey Cardiovasc J. 2014 Jan- ...
Brugada syndrome - Wikipedia
... in those with Brugada syndrome are typically dangerous arrhythmias such as ventricular fibrillation or polymorphic ventricular ... Catecholaminergic polymorphic ventricular tachycardia. References. *^ a b c d e f g h "Brugada syndrome". Genetics Home ... Sarquella-Brugada G, Campuzano O, Arbelo E, Brugada J, Brugada R (January 2016). "Brugada syndrome: clinical and genetic ... Brugada J, Brugada P, Brugada R (July 1999). "The syndrome of right bundle branch block ST segment elevation in V1 to V3 and ...
SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome -...
SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome ... SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome ... SCN5A gene mutations and the risk of ventricular fibrillation and syncope in Brugada syndrome patients: A meta-analysis. ... Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram ...
Ventricular fibrillation - Wikipedia
Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, ... MacWilliam spent many years working on ventricular fibrillation and was one of the first to show that ventricular fibrillation ... on the basis of the fact that ventricular fibrillation itself is common, idiopathic ventricular fibrillation accounts for an ... of the cases of ventricular fibrillation unrelated to myocardial infarction, and 14% of all ventricular fibrillation ...
Brugada Syndrome | Revista Española de Cardiología (English Edition)
Brugada J, Brugada P, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998;392: ... Benito B, Brugada J, Brugada R, Brugada P. Brugada syndrome or Brugada electrocardiogram? Authors reply. J Am Coll Cardiol. ... Brugada Syndrome. Begoña Benito a, Josep Brugada b, Ramón Brugada c, Pedro Brugada d. a Electrophysiology Research Program, ... Benito B, Brugada R, Brugada J, Brugada P. Brugada syndrome. Prog Cardiovasc Dis. 2008;51:1-22. Medline. 17. Vatta M, Dumaine R ...
Frontiers | Novel SCN5A Frameshift Mutation in Brugada Syndrome Associated With Complex Arrhythmic Phenotype | Genetics
The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered from ... The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered from ... in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). ... in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). ...
Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the...
... protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current. ... Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the ... Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the ... Brugada syndrome risk loci seem protective against atrial fibrillation. Andreasen L, Nielsen JB, Darkner S, Christophersen IE, ...
Recurrent ventricular fibrillation during a febrile illness as the first manifestation of Brugada syndrome - a case report |...
Recurrent ventricular fibrillation during a febrile illness as the first manifestation of Brugada syndrome - a case report. ... Recurrent ventricular fibrillation during a febrile illness as the first manifestation of Brugada syndrome - a case report ... Abstract: A case of a 33-year-old male who was admitted to the hospital due to recurrent ventricular fibrillation during a ... Abstract: A case of a 33-year-old male who was admitted to the hospital due to recurrent ventricular fibrillation during a ...
Brugada Syndrome Differential Diagnoses
Brugada syndrome is a disorder characterized by sudden death associated with one of several ECG patterns characterized by ... Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome. Heart Rhythm. 2012 ... Antzelevitch C, Brugada P, Brugada J, Brugada R. Brugada syndrome: from cell to bedside. Curr Probl Cardiol. 2005 Jan. 30(1):9- ... Guideline] Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. Brugada syndrome: report of the ...
Brugada Syndrome - Causes, Symptoms, Diagnosis & Treatment
Brugada syndrome is a rare genetic heart condition that affects the way electrical signals pass through the heart causing the ... The main symptom is irregular ventricular heartbeats (ventricular fibrillation) which may potentially result in sudden death ... What is Brugada Syndrome?. Brugada syndrome (BrS) is a recently identified disorder. Brugada syndrome is a rare but serious ... Brugada syndrome (BrS) is a rare genetic heart disorder characterized by an abnormal electrocardiogram [ECG] due to ventricular ...
Sex Differences in Autonomic Response to Exercise Testing in Patients with Brugada Syndrome | SpringerLink
Cardiac events in patients with Brugada syndrome (BS) typically occur at rest and mainly during sleep, suggesting that changes ... The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. Eur Heart J. 1999;20(6 ... Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3 : a marker for ... Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical ...
Frontiers | The genetic component of Brugada syndrome | Physiology
BrS is characterized by ST-segment elevations in the right precordial leads and susceptibility to ventricular arrhythmias and ... BrS is characterized by ST-segment elevations in the right precordial leads and susceptibility to ventricular arrhythmias and ... Brugada Syndrome (BrS) is a clinical entity first described in 1992. ... Brugada Syndrome (BrS) is a clinical entity first described in 1992. ...
Cardiac Na+ Channel Dysfunction in Brugada Syndrome Is Aggravated by β1-Subunit | Circulation
fibrillation. Idiopathic ventricular fibrillation (IVF) is a clinical disorder characterized by development of ventricular ... Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang ... Idiopathic ventricular fibrillation in out-of-hospital cardiac arrest survivors. Pacing Clin Electrophysiol. 1994;17:1405-1412. ... Brugada J, Brugada P. What to do in patients with no structural heart disease and sudden arrhythmic death? Am J Cardiol. 1996; ...
Management of patients with a Brugada ECG pattern
Documented ventricular arrhythmias:. Polymorphic ventricular tachycardia (PVT).. Ventricular fibrillation (VF).. BS is ... 22) Benito B, Brugada R, Brugada J, Brugada P. Brugada syndrome. Prog Cardiovasc Dis 2008 July;51(1):1-22.. (23) Priori SG, ... 32) Antzelevitch C, Brugada P, Brugada J, Brugada R. Brugada syndrome: From cell to bedside. Current Problems in Cardiology ... 24) Brugada P, Brugada R, Brugada J. Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and ...
Distribution and Prognostic Significance of Fragmented QRS in Patients With Brugada Syndrome | Circulation: Arrhythmia and...
Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular ... Idiopathic Ventricular Fibrillation Investigators. New ECG criteria for high-risk Brugada syndrome. Circ J. 2003;67:8-10. ... Paced QRS fragmentation is associated with spontaneous ventricular fibrillation in patients with Brugada syndrome. Heart Rhythm ... Mode of onset of ventricular fibrillation in patients with Brugada syndrome detected by implantable cardioverter defibrillator ...
Ajmaline - Wikipedia
Brugada syndrome can result in ventricular fibrillation and potentially death. It is a major cause of sudden unexpected cardiac ... Brugada syndrome is a genetic disease that result in mutations in the sodium ion channel (gene SCN5A) of the myocytes in the ... It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome. The compound ... Ajmaline is used intravenously to test for Brugada syndrome since they both affect the sodium ion channel. In an afflicted ...
Antiarrhythmic Induced Electrical Storm in Brugada Syndrome: A Case Report
Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various ... Brugada syndrome (BS) may be unmasked by several pharmacological and/or physiological agents in an otherwise normal ... Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various ... Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal ...
Caridac Arrhythmias Flashcards by Emma Goodall | Brainscape
What are the ventricular arrhythmias? Premature ventricular complex, ventricular tachycardia, ventricular fibrillation and ... Cardiomyopathy, inherited or familial arrhythmia syndromes e.g. Long QT or brugada syndrome. ... Rate of 300, ventricular usually 150.. No P waves but saw tooth f wave.. Normal QRS.. Normal conduction but physiologic 2:1. ... Chaotic ventricular electrical activity, which causes the heart to lose the ability to function like a pump.. Needs ...
Ventricular fibrillation - wikidoc
Inherited Disease • Brugada Syndrome Systemic Diseases • CNS Disease • Cardiac Tumors Heart Transplantation • EKG Changes in ... Premature Ventricular Contractions (PVCs) • Ventricular tachycardia • Ventricular Fibrillation • Sudden cardiac death ... Differentiating Ventricular Fibrillation from other Diseases. Epidemiology and Demographics. Risk Factors. Natural History, ... de:Kammerflimmern he:פרפור חדרים it:Fibrillazione ventricolare nl:Ventrikelfibrilleren simple:Ventricular fibrillation fi: ...
Kawamura Y[au] - PubMed - NCBI
Brugada Syndrome - The Clinical Advisor
... and isassociated with a relatively high risk of sudden cardiac death due to ventricular fibrillation (VF) without major ... Age and Brugada syndrome B. History Part 2: Prevalence:. Clinical Characteristics Part 2: Prevalence. Prevalence of Brugada-ECG ... Circadian pattern of ventricular fibrillation in Brugada syndrome. Figure 3.. ... I. Brugada Syndrome: What every physician needs to know. * II. Diagnostic Confirmation: Are you sure your patient has Brugada ...
Fever Associated with Gastrointestinal Shigellosis Unmasks Probable Brugada Syndrome
The syndrome is clinically significant since these patients are at a higher risk of developing malignant ventricular ... the Brugada Syndrome has spurred a significant quantity of interest in its underlying mechanism and physiology. The Brugada ... We present the case of a 35-year-old male who presented with intestinal Shigellosis and was also found to have Brugada-type ... Q. Chen, G. E. Kirsch, D. Zhang et al., "Genetic basis and molecular mechanism for idiopathic ventricular fibrillation," Nature ...
Intermittent Brugada Pattern in Relation to Changes in Body Temperature | Revista Española de Cardiología (English Edition)
As per emergency medical system records, initial rhythm was ventricular fibrillation. The patient was intubated and shocked 4 ... Intermittent Brugada Pattern in Relation to Changes in Body Temperature. Andre Dias a,. , Emiliana Franco a, Vincent M. ... Electrocardiogram performed on arrival (Figure 1) suggested possible Brugada syndrome. The hypothermia protocol was started. ... A repeat electrocardiogram was once again compatible with Brugada syndrome (Figure 3). ...
Interleukin-7 (CYT107) Treatment of Idiopathic CD4 Lymphocytopenia: Expansion of CD4 T Cells (ICICLE) - Full Text View -...
JCI - PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes. Circulation. 2003;108(8):925- ... Role of left ventricular scar and Purkinje-like potentials during mapping and ablation of ventricular fibrillation in dilated ... Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ... Pcp4-null mice are prone to ventricular arrhythmias and aberrant ventricular conduction. (A-E) Representative ECG tracings from ...
JCI - Molecular and genetic basis of sudden cardiac death
Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular ... A novel SCN5A mutation, F1344S, identified in a patient with Brugada syndrome and fever-induced ventricular fibrillation. ... KCNE5 (KCNE1L) Variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm ... Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden ...
SyndromeIdiopathic ventricularSudden cardiArrhythmiaPolymorphicSyncopeCardiac arrestRight ventricular outflTerminating ventricular tachycardiaElectrocardiogramLeft ventricular noncompactionOutflowSCN5A1992TachyarrhythmiasHypertrophic cardiomyopathyAblationCardiomyopathyPhenotypeClinicalPatients with atrial fibrillationGeneticEpisodesConductionAbnormalElectrocardiographicElevationAtrial and ventricularParoxysmal Atrial FibriAbnormalitiesTachycardiasStructuralAsymptomaticLQTSStructurally normal heartPremature ContractionsImplantable cardioverterDefibrillationLife-threatening ventricular
- Idiopathic ventricular fibrillation can be caused by subclinical channelopathies such as Brugada syndrome. (pagepressjournals.org)
- The flecainide challenge test was positive for Brugada syndrome in two subjects in the case group and none in the control group. (pagepressjournals.org)
- The D1816fs/g98747-98748insT mutation in SCN5A may be associated with idiopathic ventricular fibrillation and Brugada syndrome with a broad phenotypic spectrum and incomplete penetrance. (pagepressjournals.org)
- IMSEAR at SEARO: Ventricular Fibrillation with Brugada Syndrome: A Case Report. (who.int)
- Brugada syndrome is a potentially lethal and eminently treatable entity that may present with palpitations or syncope. (who.int)
- This article presents the case of a young patient with Brugada syndrome and reviews key features in the epidemiology, pathophysiology, diagnosis, treatment and prognosis of this condition. (who.int)
- ABSTRACT Introduction: Brugada syndrome describes a subgroup of patients at risk for polymorphic ventricular tachycardia, ventricular fibrillation, and sudden cardiac death and is likely underdiagnosed among aviators. (redorbit.com)
- The Aeromedicai Consultation Service should review all cases of Brugada syndrome and render a return to fly for asymptomatic nondiagnostic Brugada types. (redorbit.com)
- Brugada syndrome refers to a disorder caused by defective cardiac ion channels and is characterized by the risk of developing polymorphic ventricular tachycardia (VT), ventricular fibrillation (VF), and death. (redorbit.com)
- Detailed cardiologic work-up eventually confirmed a diagnosis of type 1 Brugada syndrome. (redorbit.com)
- Considered a cardiac ion channel defect, type 1 Brugada syndrome carries a strong probability of permanent disqualification from aviation duties because of the risks associated with sudden cardiovascular incapacitation during flight. (redorbit.com)
- Most patients with Brugada syndrome are asymptomatic. (redorbit.com)
- This did not definitively confirm the diagnosis of Brugada syndrome, and hence a procainamide challenge was performed. (redorbit.com)
- Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm . (medlineplus.gov)
- Brugada syndrome usually becomes apparent in adulthood, although it can develop any time throughout life. (medlineplus.gov)
- Researchers have determined that SUNDS and Brugada syndrome are the same disorder. (medlineplus.gov)
- The exact prevalence of Brugada syndrome is unknown, although it is estimated to affect 5 in 10,000 people worldwide. (medlineplus.gov)
- Although Brugada syndrome affects both men and women, the condition appears to be 8 to 10 times more common in men. (medlineplus.gov)
- Brugada syndrome can be caused by mutations in one of several genes. (medlineplus.gov)
- A disruption in ion transport alters the way the heart beats, leading to the abnormal heart rhythm characteristic of Brugada syndrome. (medlineplus.gov)
- Mutations in other genes can also cause Brugada syndrome. (medlineplus.gov)
- Some of the additional genes involved in Brugada syndrome provide instructions for making proteins that ensure the correct location or function of sodium channels in heart muscle cells. (medlineplus.gov)
- In affected people without an identified gene mutation, the cause of Brugada syndrome is often unknown. (medlineplus.gov)
- Abnormally high blood levels of calcium (hypercalcemia) or potassium (hyperkalemia), as well as unusually low potassium levels (hypokalemia), also have been associated with acquired Brugada syndrome. (medlineplus.gov)
- Brugada syndrome ( BrS ) is a genetic disorder in which the electrical activity within the heart is abnormal. (wikipedia.org)
- The abnormal heart rhythms seen in those with Brugada syndrome often occur at rest. (wikipedia.org)
- About a quarter of those with Brugada syndrome have a family member who also has the condition. (wikipedia.org)
- There is no cure for Brugada syndrome. (wikipedia.org)
- While many of those with Brugada syndrome do not have any symptoms, Brugada syndrome may cause fainting or sudden cardiac death due to serious abnormal heart rhythms such as ventricular fibrillation or polymorphic ventricular tachycardia . (wikipedia.org)
- However, blackouts can occur in those with Brugada syndrome despite a normal heart rhythm due to a sudden drop in blood pressure, known as vasovagal syncope . (wikipedia.org)
- The abnormal heart rhythms seen in Brugada syndrome often occur at rest, following a heavy meal, or even during sleep. (wikipedia.org)
- Certain medications may also worsen the tendency to abnormal heart rhythms in patients with Brugada syndrome and should be avoided by these patients. (wikipedia.org)
- The individual cells of the heart communicate with each other with electrical signals, and these electrical signals are disrupted in those with Brugada syndrome. (wikipedia.org)
- The first mutations described in association with Brugada syndrome were in a gene responsible for a protein or ion channel that controls the flow of sodium ions through the cell membrane of heart muscle cells - the cardiac sodium channel . (wikipedia.org)
- Many of the genetic mutations that have subsequently been described in association with Brugada syndrome influence the sodium current in some way, or affect other ionic currents. (wikipedia.org)
- Mutations in SCN5A are reportedly linked to Brugada syndrome (BS), but recent observations suggest that they are not necessarily associated with ventricular fibrillation (VF) in BS patients. (cdc.gov)
- First described in 1992, Brugada syndrome is characterized by a specific electrocardiographic pattern in the right precordial leads and susceptibility to ventricular arrhythmias and sudden death. (revespcardiol.org)
- Brugada syndrome is included among the channelopathies, primary electrical disorders that, characteristically, are not associated with concomitant structural cardiac abnormalities. (revespcardiol.org)
- This article provides a summary of what is currently known about Brugada syndrome and an overview of the principal preclinical and clinical studies that have made the most significant contributions to our understanding of the condition. (revespcardiol.org)
- The syndrome of right bundle branch block, ST segment elevation and sudden cardiac death (SCD), better known today as Brugada syndrome, was described in 1992 as a new clinical and electrocardiographic syndrome involving susceptibility to ventricular arrhythmias and SCD in patients without obvious structural heart disease. (revespcardiol.org)
- 6-8 This review provides a summary of what is currently known about Brugada syndrome and up-to-date information from the main clinical and experimental studies published in recent years. (revespcardiol.org)
- With more patients with Brugada syndrome being identified, certain questions soon arose regarding the definition of its characteristic electrocardiographic (ECG) pattern and the diagnostic criteria for the disease. (revespcardiol.org)
- Although the 3 patterns can be observed in Brugada syndrome, and even in the same patient at different times, type I is the only one that is considered diagnostic of the disease, as specified in the 2 consensus documents published in 2002 and 2005. (revespcardiol.org)
- Electrocardiographic patterns (ECG) that can be found in the patients with Brugada syndrome. (revespcardiol.org)
- Brugada syndrome is included among the so-called channelopathies, that is, diseases produced by alterations in the transmembrane ion channels that participate in cell action potential, and which lead to an increased susceptibility to arrhythmias. (revespcardiol.org)
- In this case report, we characterize a novel inherited frameshift mutation c.4700_4701del (p.Phe1567Cysfs * 221) in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). (frontiersin.org)
- The Brugada syndrome (BrS) is characterized by a coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG) and an increased risk of sudden cardiac death (SCD). (frontiersin.org)
- Brugada syndrome is inherited as an autosomal dominant condition with incomplete penetrance. (frontiersin.org)
- Recently described syndromes such as the Brugada Syndrome may give clues to the underlying mechanism of ventricular arrhythmias. (wikipedia.org)
- In the Brugada syndrome, changes may be found in the resting ECG with evidence of right bundle branch block (RBBB) and ST elevation in the chest leads V1-V3, with an underlying propensity to sudden cardiac death. (wikipedia.org)
- The differential diagnosis of cardiac arrest in an otherwise presumably healthy subject is varied, but it includes such entities as acute cardiac ischemia due to atherosclerosis or coronary anomaly, hypertrophic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, long QT syndrome, and arrhythmogenic right ventricular cardiomyopathy (ARVC). (medscape.com)
- Incidence, clinical implications and prognosis of atrial arrhythmias in Brugada syndrome. (medscape.com)
- Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome. (medscape.com)
- Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. (medscape.com)
- Brugada J, Brugada R, Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. (medscape.com)
- Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. (medscape.com)
- Vorobiof G, Kroening D, Hall B, Brugada R, Huang D. Brugada syndrome with marked conduction disease: dual implications of a SCN5A mutation. (medscape.com)
- Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. (medscape.com)
- Alings M, Wilde A. "Brugada" syndrome: clinical data and suggested pathophysiological mechanism. (medscape.com)
- Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? (medscape.com)
- Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome. (medscape.com)
- Antzelevitch C, Brugada P, Brugada J, Brugada R. Brugada syndrome: from cell to bedside. (medscape.com)
- Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation. (medscape.com)
- An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. (medscape.com)
- What is Brugada Syndrome? (medindia.net)
- Brugada syndrome (BrS) is a recently identified disorder. (medindia.net)
- Brugada syndrome is a rare but serious heart condition that affects the way electrical signals pass through the heart. (medindia.net)
- Spanish cardiologists Pedro Brugada and Joseph Brugada reported it as a distinct clinical syndrome in 1992. (medindia.net)
- Brugada syndrome (BrS) is a rare genetic heart disorder characterized by an abnormal electrocardiogram [ECG] due to ventricular arrhythmias. (medindia.net)
- Brugada syndrome is characterized by the presence of ST-segment elevation in leads V 1 to V 3 . (medindia.net)
- Many people who have Brugada syndrome are apparently asymptomatic, have structurally normal hearts and are unaware of their condition. (medindia.net)
- Studies indicate that Brugada syndrome is responsible for 4%-12% of unexpected sudden deaths and for up to 20% of all sudden deaths in apparently normal individuals with no previous heart conditions. (medindia.net)
- The average age of persons afflicted with Brugada syndrome is 35-40 years. (medindia.net)
- Brugada syndrome has been found to be more prevalent among males. (medindia.net)
- Brugada syndrome is clinically related with sudden and unexpected death syndrome (SUDS), sudden unexpected nocturnal death syndrome (SUNDS) and sudden infant death syndrome (SIDS). (medindia.net)
- According to the National Institutes of Health it is estimated that 5 in 10,000 people worldwide are affected by the Brugada syndrome. (medindia.net)
- As awareness of Brugada syndrome increases among medical fraternity and public it can be expected that the number of identifiable cases worldwide will also increase. (medindia.net)
- What is the Genetics behind Brugada Syndrome? (medindia.net)
- Brugada syndrome predominantly has a genetic cause. (medindia.net)
- The primary gene associated with Brugada syndrome is located on chromosome 3 and is known as the SCN5A gene. (medindia.net)
- Approximately 15%-30% of individuals with Brugada syndrome have a SCN5A gene mutation. (medindia.net)
- These genes have varying mechanisms and expressions associated with Brugada Syndrome. (medindia.net)
- What are the Causes of Brugada syndrome? (medindia.net)
- Brugada syndrome is mostly inherited as an autosomal dominant. (medindia.net)
- What are the Signs & Symptoms of Brugada syndrome? (medindia.net)
- Cardiac events in patients with Brugada syndrome (BS) typically occur at rest and mainly during sleep, suggesting that changes in autonomic modulation play an important role in the arrhythmogenesis of the disease. (springer.com)
- Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. (springer.com)
- Gender differences in clinical manifestations of Brugada syndrome. (springer.com)
- Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. (springer.com)
- The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. (springer.com)
- Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways. (springer.com)
- Cardiac autonomic dysfunction in Brugada syndrome. (springer.com)
- Brugada syndrome (BrS) is a clinical entity first described in 1992. (frontiersin.org)
- Background -Mutations in the gene encoding the human cardiac Na + channel α-subunit (hH1) are responsible for chromosome 3-linked congenital long-QT syndrome (LQT3) and idiopathic ventricular fibrillation (IVF). (ahajournals.org)
- This is now called the Brugada syndrome and represents a distinct syndrome of IVF. (ahajournals.org)
- The clinical features of the Brugada syndrome can be attributed to early repolarization, depolarized areas of right ventricular myocardium, or focal right ventricular conduction abnormalities. (ahajournals.org)
- Recent genetic studies have confirmed that the Brugada syndrome and chromosome 3-linked congenital long-QT syndrome (LQT3) are allelic disorders of the cardiac Na + channel α-subunit gene ( SCN5A , 3p21). (ahajournals.org)
- 4 5 At present, 3 SCN5A mutations have been demonstrated in the Brugada syndrome: a splice-donor mutation, a frame-shift mutation, and a missense mutation. (ahajournals.org)
- 5 It is not clear, however, whether these rather subtle functional defects of T1620M are sufficient to cause ECG abnormalities and predisposition to lethal ventricular arrhythmias in Brugada syndrome patients or whether some other factors involved in the functional association with mutant channel molecules may give rise to aggravation of the biophysical abnormality in vivo. (ahajournals.org)
- Although the estimated prevalence of the Brugada Syndrome makes it a rare disease - it ranges from 1-5/10 000 in Europe to 12/ 10 000 inhabitants in Southeast Asia, the implied risk of a tragic and preventable event - sudden death - in young and, otherwise, healthy individuals has attracted great interest from scientists all over the world. (escardio.org)
- Brugada syndrome (BS), first described in 1992, is an inherited arrhythmogenic disease, characterised by coved-type ST-segment elevation in right precordial leads and an increased risk of sudden cardiac death (SCD), due to ventricular fibrillation (VF)1. (escardio.org)
- Background- Fragmented QRS complexes (fQRS) in the right precordial leads are associated with occurrence of ventricular fibrillation (VF) in Brugada syndrome. (ahajournals.org)
- Methods and Results- We evaluated the existence of fQRS in 456 patients with Brugada syndrome, including 117 patients with syncope and 23 patients with VF. (ahajournals.org)
- Conclusions- The distribution of fQRS is associated with prognosis in Brugada syndrome, further supporting the association of fQRS and arrhythmia substrate. (ahajournals.org)
- fQRS in the right precordial leads represents electrophysiological abnormality of the right ventricular outflow tract (RVOT) and is associated with lethal arrhythmic events in patients with Brugada syndrome. (ahajournals.org)
- Epicardial mapping and ablation have revealed that the existence of delayed potential on the epicardium of RVOT is a substrate of ECG change and ventricular arrhythmia in Brugada syndrome, and it is also recorded outside of RVOT region. (ahajournals.org)
- It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome. (wikipedia.org)
- Brugada syndrome is a genetic disease that result in mutations in the sodium ion channel (gene SCN5A) of the myocytes in the heart. (wikipedia.org)
- Brugada syndrome can result in ventricular fibrillation and potentially death. (wikipedia.org)
- While the characteristic patterns of Brugada syndrome on an electrocardiogram may be seen regularly, often the abnormal pattern is only seen spontaneously due to unknown triggers or after challenged by particular drugs. (wikipedia.org)
- Ajmaline is used intravenously to test for Brugada syndrome since they both affect the sodium ion channel. (wikipedia.org)
- Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. (nih.gov)
- I. Brugada Syndrome: What every physician needs to know. (clinicaladvisor.com)
- Brugada syndrome is characterized by a coved-type ST segment elevation in the right precordial leads of the electrocardiogram (ECG) and isassociated with a relatively high risk of sudden cardiac death due to ventricular fibrillation (VF) without major structural heart disease. (clinicaladvisor.com)
- Since its introduction, the Brugada syndrome has attracted great interest because of its high incidence in many parts of the world and its association with high risk of sudden death in young and otherwise healthy adults, and less frequently in infants and children. (clinicaladvisor.com)
- Diagnostic Confirmation: Are you sure your patient has Brugada Syndrome? (clinicaladvisor.com)
- Type 1 or coved-type ST segment elevation, characterized by a J point elevation of ≥2 mm (0.2 mV) followed by a negative or isoelectric T wave, is diagnostic of Brugada syndrome. (clinicaladvisor.com)
- ECG of Brugada syndrome. (clinicaladvisor.com)
- Differential diagnosis of the Brugada syndrome must be approached with care since ST segment elevation is associated with a wide variety of conditions. (clinicaladvisor.com)
- Worldwide prevalence of Brugada syndrome is estimated to be 1 in 10,000, but is much higher in Asian and Southeast Asian countries, reaching 5 to 10 in 10,000 and much lower in some Eastern European countries like Denmark, with an estimated prevalence of 1.1 in 100,000. (clinicaladvisor.com)
- The frequency is higher (≥5 per 10,000) in Southeast Asia, especially Thailand and the Philippines where the Brugada syndrome is considered to be the major cause of sudden death in young individuals. (clinicaladvisor.com)
- In Japan, type-1 ST segment elevation diagnostic of Brugada syndrome was observed in 12 per 10,000 inhabitants, whereas type-2 and type-3 ECG were much more prevalent, appearing in 58 per 10,000 inhabitants. (clinicaladvisor.com)
- Since it was first described approximately 15 years ago, the Brugada Syndrome has spurred a significant quantity of interest in its underlying mechanism and physiology. (hindawi.com)
- The syndrome is clinically significant since these patients are at a higher risk of developing malignant ventricular arrhythmias. (hindawi.com)
- Electrocardiogram performed on arrival ( Figure 1 ) suggested possible Brugada syndrome. (revespcardiol.org)
- Forty-eight hours later he complained of productive cough with yellowish sputum and shortness of breath and spiked a fever of 38.3 °C. A repeat electrocardiogram was once again compatible with Brugada syndrome ( Figure 3 ). (revespcardiol.org)
- Recent data suggest that loss of the action potential dome in right ventricular epicardium but not endocardium underlies the ST segment elevation seen in the Brugada syndrome (9-10). (fac.org.ar)
- In addition to a prolonged QT interval, which occurs in some but not all persons with long QT syndrome, another characteristic electrocardiographic abnormality is the so-called Brugada sign (an upward deflection of the terminal portion of the QRS complex). (aafp.org)
- SADS encompasses a number of clinical entities, including congenital long QT syndrome, Wolff-Parkinson-White syndrome, idiopathic ventricular fibrillation, and coronary artery spasm (e.g., from cocaine intoxi cation). (aafp.org)
- In patients who undergo aborted sudden cardiac death or syncope of unknown origin (symptomatic Brugada syndrome), no one argues that the implantation of an ICD is the first-line therapy regardless of the findings of the EP study. (cogprints.org)
- 11, performed EP-guided medical therapy in 34 patients with idiopathic VF, in 5 of whom the criterion of Brugada syndrome were fulfilled, and reported excellent long-term results. (cogprints.org)
- An EP study is usually used to examine the preventive effects of antiarrhythmic agents on sustained ventricular tachycardia in patients with structural heart disease, whereas the prognostic value of the EP study in predicting life-threatening events in Brugada syndrome is still controversial. (cogprints.org)
- 23 failed to find an association between the inducibility and recurrence of VT/VF in patients with Brugada syndrome regardless of whether it was symptomatic or asymptomatic. (cogprints.org)
- In patients with asymptomatic Brugada syndrome who are family members of symptomatic Brugada syndrome patients, the same strategy as that for the symptomatic Brugada syndrome patients should be considered 2,3,4. (cogprints.org)
- Brugada syndrome was first reported as a distinct entity in 1992. (springer.com)
- Initially thought of as a rare entity, Brugada syndrome is now widely recognized as a common cause of natural death among young men as a result of ventricular arrhythmia occurring at rest, particularly during sleep. (springer.com)
- However, mutation in a single gene could be implicated in less than 30% of patients with Brugada syndrome, and a recent study showing association of this disease with common single nucleotide polymorphism of SCN5A , SCN10A , and HEY2 pointed toward polygenic or oligogenic pattern of inheritance rather than a single gene defect. (springer.com)
- Brugada syndrome is now viewed as a spectrum of cardiomyopathy as well as channelopathy. (springer.com)
- The pathophysiologic underlying cardiac arrhythmia in Brugada syndrome is still unresolved with continued debate on depolarization versus repolarization defect. (springer.com)
- The authors would like to thank the National Research Council of Thailand (NRCT) for support on the study of Brugada syndrome. (springer.com)
- Adler A. Brugada syndrome: diagnosis, risk stratification, and management. (springer.com)
- Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, Nakazawa K, Kimura A, Hiraoka M. A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. (springer.com)
- Brugada syndrome is a heart condition that causes a disruption of the normal rhythm in the heart's lower chambers (ventricular arrhythmia). (nih.gov)
- Brugada syndrome may be caused by a mutation in any of at least 16 genes (most commonly the SCN5A gene) and is inherited in an autosomal dominant manner. (nih.gov)
- In some cases, the cause of Brugada syndrome is unknown. (nih.gov)
- While symptoms of Brugada syndrome usually develop in adulthood, they can develop at any age. (nih.gov)
- Sudden cardiac arrest may be the initial symptom of Brugada syndrome in as many as one-third of affected people. (nih.gov)
- The genetic form of Brugada syndrome (not the acquired form) is inherited in an autosomal dominant manner. (nih.gov)
- Almost all people with Brugada syndrome have a parent with the condition. (nih.gov)
- Some arrhythmias are congenital such as Long QT Syndrome (LQTS), Brugada Syndrome (BrS), atrial fibrillation e.t.c. (exclusivepapers.com)
- Brugada syndrome (BrS) is an autosomal dominant inherited disorder caused by mutations mainly in the SCN5A gene. (go.jp)
- This is a report of a child with Brugada syndrome who experienced ventricular fibrillation storm. (biomedsearch.com)
- A 35-year-old man showed a convulsive attack with consciousness loss and was suspected of having Brugada syndrome 6 months prior to admission to our hospital. (neurology-jp.org)
- The patient was diagnosed with Brugada syndrome and received implantable cardioverter defibrillator (ICD). (neurology-jp.org)
- Brugada syndrome is an inheritable cardiac disease causing sudden death by ventricular fibrillation. (neurology-jp.org)
- The patient did not have typical ECG findings of Brugada syndrome. (snpedia.com)
- PMID 11827685 ] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease. (snpedia.com)
- PMID 17141278 ] A novel mutation in the SCN5A gene is associated with Brugada syndrome. (snpedia.com)
- Abstract -Mutations in SCN5A , the gene encoding the cardiac Na + channel, have been identified in 2 distinct diseases associated with sudden death: one form of the long-QT syndrome (LQT 3 ) and the Brugada syndrome. (ahajournals.org)
- LQT 3 and Brugada syndrome are allelic disorders but may also share a common genotype. (ahajournals.org)
- SCN5A, the gene that encodes the human cardiac Na + channel α subunit, 1 is mutated in one form of the long-QT syndrome (LQT 3 ) and in Brugada syndrome. (ahajournals.org)
- 5 6 QT intervals have been reported to be normal in patients with Brugada syndrome. (ahajournals.org)
- 10 Although functional abnormalities have been described for Brugada syndrome-related SCN5A mutant channels, 3 11 the mechanism(s) whereby these explain the Brugada phenotype are less clear. (ahajournals.org)
- In this study we present clinical and genetic data of a single large SCN5A -linked family, phenotypically characterized by nocturnal death and electrocardiographically by both LQT 3 and Brugada syndrome features in the same patients. (ahajournals.org)
- We show that LQT 3 and the Brugada syndrome are more closely related than heretofore appreciated and can even be caused by the same mutation. (ahajournals.org)
- PAF, Brugada syndrome, idiopathic ventricular fibrillation). (bvsalud.org)
- What is the arrhythmogenic substrate in the Brugada Syndrome (BrS)? (acc.org)
- Brugada syndrome has been linked to mutations in SCN5A. (ahajournals.org)
- Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. (ahajournals.org)
- Lidocaine, an agent with rapid dissociation kinetics, has previously been shown to exert no effect in patients with Brugada syndrome. (ahajournals.org)
- We characterized a novel double mutation of SCN5A (V232I in DI-S4+L1308F in DIII-S4) identified in a rare case of lidocaine (1 mg/kg)-induced Brugada syndrome. (ahajournals.org)
- Brugada syndrome (BrS) is an inherited cardiac disease characterized by an ST segment elevation in the right precordial electrocardiogram (ECG) leads (V1 to V3) and a high incidence of sudden death. (ahajournals.org)
- We report a 6-month-old Japanese infant with a malignant form of Brugada syndrome, who had frequent episodes of ventricular fibrillation (VF) and nonsustained polymorphic ventricular tachycardia (VT). (nih.gov)
- To the best of our knowledge, this infant is the youngest patient reported to have Brugada syndrome. (nih.gov)
- Journal Article] Lack of genotype-phenotype correlation in Brugada syndrome and sudden arrhythmic death syndrome families with reported pathogenic SCN1B variants. (nii.ac.jp)
- Polymorphic ventricular tachycardia (VT) is rare and generally occurs in patients with genetic ion channel disorders including long QT syndrome, Brugada syndrome, catecholaminergic polymorphic VT, and short QT syndrome. (onlinejacc.org)
- Another fascinating area, idiopathic ventricular fibrillation and early repolarization syndrome, are undergoing research for a genetic basis. (onlinejacc.org)
- This disease is now frequently called "Brugada syndrome" (BrS). (biomedcentral.com)
- Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. (thefreedictionary.com)
- Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent? (medscape.com)
- 2010). Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs Brugada syndrome. (springermedizin.de)
- The recommendations focus on genetic testing for 13 inherited cardiac conditions including: Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Brugada Syndrome, Progressive Cardiac Conduction Disease, Short QT Syndrome, Atrial Fibrillation, Hypertrophic Cardiomyopathy, Arrhythmogenic Cardiomyopathy/Arrhythmogenic Right Ventricular Cardiomyopathy, Dilated Cardiomyopathy, Left Ventricular Noncompaction and Restrictive Cardiomyopathy. (scienceblog.com)
- Other etiologies that carry an increased risk of VF include various cardiomyopathies, the Brugada syndrome, drowning, metabolic abnormalities such as acidosis or hypokalemia, and side effects of medications that affect membrane ion conductance channels. (massgeneral.org)
- Besides long QT syndrome, other abnormalities of the heart's electrical system, such as Brugada syndrome, can cause sudden death. (self.com)
- Electrocardiographic changes were evaluated retrospectively in five patients without previous episodes of syncope or ventricular fibrillation who developed abnormal ST segment elevation mimicking the Brugada syndrome in leads V1-V3 after the administration of class Ic antiarrhythmic drugs. (bmj.com)
- In 1992, Brugada and Brugada 1 reported a study of eight patients with idiopathic ventricular fibrillation who showed ST segment elevation in the right precordial lead (the Brugada syndrome). (bmj.com)
- Recent studies 2-4 have reported that class I antiarrhythmic drugs such as flecainide, procainamide, and ajmaline could unmask ST segment elevation in patients with "latent" Brugada syndrome. (bmj.com)
- In addition, we reported the first case 5 of a patient who had no previous syncope or ventricular fibrillation, but who showed electrocardiographic changes mimicking those of the Brugada syndrome after administration of a class Ic antiarrhythmic drug. (bmj.com)
- Serious cardiac causes include myocardial ischemia or other myocardial disorders, congenital heart disease (eg, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, congenital long QT syndrome ), valvular heart disease , and conduction system disturbances (eg, disturbances that cause bradycardia or heart block ). (merckmanuals.com)
- Brugada syndrome is an example of a channelopathy caused by an alteration in the transmembrane ion currents that together constitute the cardiac action potential. (rcpjournals.org)
- Approximately 20% of the cases of Brugada syndrome have been shown to be associated with mutations in the gene coding for the sodium ion channel in the cell membranes of the muscle cells of the heart. (rcpjournals.org)
- Patients with Brugada syndrome are prone to develop ventricular tachyarrhythmias that may lead to syncope, cardiac arrest or sudden cardiac death. (rcpjournals.org)
- Many clinical situations have been reported to unmask or exacerbate the electrocardiography (ECG) pattern of Brugada syndrome. (rcpjournals.org)
- Genetic testing for Brugada syndrome is clinically available. (rcpjournals.org)
- Here we report two cases of Brugada syndrome followed by a comprehensive review of the literature. (rcpjournals.org)
- Brugada syndrome, an autosomal dominant condition, is a disorder characterised by sudden death associated with one of several ECG patterns characterised by incomplete right bundle-branch block and ST-segment elevations in the anterior precordial leads. (rcpjournals.org)
- At present, implantation of an automatic implantable cardiac defibrillator (ICD) is the only treatment proven effective in treating ventricular tachycardia and fibrillation and preventing sudden death in patients with Brugada syndrome. (rcpjournals.org)
- Brugada syndrome (BS), first described in 1992, 1 is a major cause of sudden cardiac death (SCD), 2 syncope and ventricular tachyarrhythmia in young people with no structural heart disease. (rcpjournals.org)
- The syndrome should be suspected in patients with documented idiopathic ventricular fibrillation, self-terminating polymorphic ventricular tachycardia, a family history of sudden cardiac death in a young person and/or syncope with the characteristic electrocardiography (ECG) changes. (rcpjournals.org)
- His repeat ECG showed RBBB with ST elevation in V1 to V2, suggesting Brugada syndrome Type 1 ( Fig 1c ). (rcpjournals.org)
- A sodium-channel blocker infusion test did not result in the typical ECG pattern of Brugada syndrome (BS), and the test attenuated J-point elevation in the inferolateral leads. (deepdyve.com)
- It may be important in cases of high suspicion for transient or concealed Brugada syndrome to detect Brugada when it does NOT show in the 4th intercostal space. (blogspot.com)
- I am an expert in cardiac arrhythmias - with particular expertise in the ablation of persistent atrial fibrillation, ventricular tachycardia and epicardial ablations including Brugada syndrome. (healthtap.com)
- He specializes in cardiac electrophysiology, and specializes in heart rhythm disorders, ranging from slow heart rhythms to irregular heart beats to fast heart rhythms, such as atrial fibrillation, atrial flutter, supraventricular arrhythmias, Wolff-Parkinson-White syndrome, ventricular tachycardia, and ventricular fibrillation. (utah.edu)
- Dr. Han also diagnoses and treats a variety of heart rhythm disorders that occur as a result of coronary artery disease, congenital heart disease, cardiac sarcoidosis, long QT syndrome, hypertrophic cardiomyopathy (HOCM), Brugada syndrome, and arrhythmogenic right ventricular dysplasia (ARVD). (utah.edu)
- Various arrhythmias are discussed in detail, from tachycardia and bradycardia to cardiomyopathy and Brugada Syndrome. (whsmith.co.uk)
- Our objective is to study the clinical behaviour of a new SCN5A mutation found in a woman with idiopathic ventricular fibrillation. (pagepressjournals.org)
- Genetic testing may be useful to identify the etiology of idiopathic ventricular fibrillation in patients with a negative thorough clinical evaluation. (pagepressjournals.org)
- Novel SCN5A mutation associated with idiopathic ventricular. (pagepressjournals.org)
- It is also notable that ventricular fibrillation occurs where there is no discernible heart pathology or other evident cause, the so-called idiopathic ventricular fibrillation. (wikipedia.org)
- Idiopathic ventricular fibrillation occurs with a reputed incidence of approximately 1% of all cases of out-of-hospital arrest, as well as 3%-9% of the cases of ventricular fibrillation unrelated to myocardial infarction, and 14% of all ventricular fibrillation resuscitations in patients under the age of 40. (wikipedia.org)
- It follows then that, on the basis of the fact that ventricular fibrillation itself is common, idiopathic ventricular fibrillation accounts for an appreciable mortality. (wikipedia.org)
- Idiopathic ventricular fibrillation (IVF) is a clinical disorder characterized by development of ventricular fibrillation without obvious structural heart disease. (ahajournals.org)
- On the other hand, there is the group of symptomatic patients who have been diagnosed as suffering syncopal episodes of unknown cause, or vaso-vagal origin, or have a diagnosis of idiopathic ventricular fibrillation. (fac.org.ar)
- OMIM 601144), or "Idiopathic ventricular fibrillation" as defined by some authors [ 1 ], is an autosomal dominant form of cardiac arrhythmia, presenting with a typical electrocardiographic (ECG) pattern of ST segment elevation in leads V1 to V3, and incomplete or complete right bundle branch block [ 2 ]. (biomedcentral.com)
- While some individuals were asymptomatic, other presentations included left ventricular non-compaction, a resuscitated cardiac arrest due to idiopathic ventricular fibrillation, dilated cardiomyopathy, and sudden unexplained death. (biomedcentral.com)
- This study describes the clinical and genetic investigations of an Australian family with marked cardiac phenotype heterogeneity among four individuals, including left ventricular non-compaction (LVNC), idiopathic ventricular fibrillation, DCM and sudden unexplained death, which lent itself to the application of exome sequencing to identify a pathogenic mutation. (biomedcentral.com)
- Play media Ventricular fibrillation is a cause of cardiac arrest and sudden cardiac death. (wikipedia.org)
- BrS is characterized by ST-segment elevations in the right precordial leads and susceptibility to ventricular arrhythmias and sudden cardiac death. (frontiersin.org)
- After diagnosis, specific tests may provide an estimate of the risk of ventricular arrhythmias and sudden cardiac death in each person. (nih.gov)
- Sustained ventricular arrhythmias are the most common cause of sudden cardiac death. (clinicaladvisor.com)
- The most common causes of sudden cardiac death in athletes are hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. (bcmj.org)
- There are many specific causes of sudden cardiac death from heart rhythm disorders (usually ventricular tachycardia or ventricular fibrillation) in apparently healthy young individuals. (cmaj.ca)
- A novel clinical entity characterized by ST segment elevation in right precordial leads (V1 to V3), incomplete or complete right bundle branch block, and susceptibility to ventricular tachyarrhythmia and sudden cardiac death has been described by Brugada et al . (biomedcentral.com)
- Simple question for the specialists: in cases of sudden cardiac death, are they all preceded by ventricular fibrillation, or sometimes the heart simply stops beating suddenly without VF? (medhelp.org)
- Specifically, this disorder can lead to irregular heartbeats in the heart's lower chambers (ventricles), which is an abnormality called ventricular arrhythmia. (medlineplus.gov)
- The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered from supraventricular tachycardia. (frontiersin.org)
- SCD is frequently caused by an abrupt change in heart rhythm (arrhythmia), most often ventricular tachycardia (VT) or ventricular fibrillation (VF), that impairs cardiac pumping, thereby depriving vital organs of oxygenated blood. (jci.org)
- The most common type of arrhythmia is atrial fibrillation, which causes an irregular and fast heart beat. (patientsville.com)
- Avoiding medications and/or conditions that predispose the patient to ventricular arrhythmia is advised in all patients. (springer.com)
- RF ablation of the epicardial substrate in the RVOT has been shown to prevent recurrence of ventricular arrhythmia in severe cases. (springer.com)
- Atrial fibrillation (AF) is the most common arrhythmia, with a prevalence of 0.4% to 1% in the general population, increasing to 8% in those older than 80 years. (clinicaladvisor.com)
- This very fast and polymorphic arrhythmia is most consistent with ventricular fibrillation. (cmaj.ca)
- Silent brain infarctions, microemboli and microbleeds, brain atrophy, cerebral hypoperfusion from widely fluctuating ventricular rates, altered hemostatic function, vascular oxidative stress, and inflammation may all exacerbate CI, particularly in patients with persistent/permanent rather than paroxysmal AF and with increased duration/burden of the arrhythmia. (bvsalud.org)
- While older studies had indicated supraventricular tachycardia as the most common tachyarrhythmia in pregnancy, more recent data indicate an increase in the frequency of arrhythmias, with atrial fibrillation (AF) emerging as the most frequent arrhythmia in pregnancy, attributed to an increase in maternal age, cardiovascular risk factors and CHD in pregnancy. (bvsalud.org)
- Emerging evidence in patients with ventricular fibrillation (VF) in a variety of clinical scenarios implicates an important role for triggers originating from the distal Purkinje arborization in the initiation of this malignant arrhythmia ( 10-14 ). (onlinejacc.org)
- Ventricular arrhythmia (VA) in structurally normal hearts can be broadly considered under non-life-threatening monomorphic and life-threatening polymorphic rhythms. (onlinejacc.org)
- Patients with ventricular arrhythmia (VA) require an evaluation to determine if structural heart disease is present ( 1 ). (onlinejacc.org)
- Life-threatening ventricular arrhythmia and Brugada-type ST-segment elevation associated with acute ischemia of the right ventricular outflow tract ," Circulation Journal, vol. (thefreedictionary.com)
- Atrial fibrillation is a common arrhythmia associated with increased cardiovascular mortality and morbidity including stroke, heart failure and hospitalisations. (smw.ch)
- Atrial fibrillation (AF), the most common arrhythmia, affects approximately 1-1.5% of the population. (smw.ch)
- Polymorphic ventricular tachycardia (PVT). (escardio.org)
- Objectives The goal of this study was to describe the mapping and ablation of polymorphic ventricular tachycardia (VT) after myocardial infarction (MI). (onlinejacc.org)
- age 61 ± 7 years) with recurrent episodes of polymorphic VT after anterior MI (left ventricular ejection fraction 32 ± 7%) despite revascularization and antiarrhythmic drugs were studied. (onlinejacc.org)
- All patients demonstrated frequent ventricular premature beats (PBs) initiating polymorphic VT. (onlinejacc.org)
- Coronary angiography can be useful to exclude coronary heart disease in patients with life-threatening VAs such as polymorphic ventricular tachycardia (PMVT) ( 1 ). (onlinejacc.org)
- Syncope, typically occurring at rest or during sleep, is a common presentation of BrS [ 3 ], and it is caused by fast polymorphic ventricular tachycardia. (biomedcentral.com)
- Discussion: Special care must be taken if ECG demonstrates a Brugada pattern-especially in patients with a history of syncope or a family history of sudden death. (redorbit.com)
- A publication has reported that the minor (and quite rare) T allele of rs137854604 was seen in a 39-year-old Japanese patient who was admitted to the hospital for recurrent syncope and suffered an episode of spontaneous ventricular fibrillation while hospitalized. (snpedia.com)
- This study included five patients (four male and one female) without previous syncope or ventricular fibrillation who showed ST segment elevation in the right precordial leads following administration of class Ic drugs (table 1 ). (bmj.com)
- There was no family history of life threatening ventricular arrhythmias, syncope, or sudden death in any of the patients. (bmj.com)
- Paroxysmal supraventricular and ventricular tachycardias (occasional episodes of very rapid heartbeat above or in the ventricles, that start and stop suddenly) - Supraventricular arrhythmias with extreme fast heart rates, even though non-life threatening, can cause hemodynamic (blood flow) compromise with syncope such as atrial fibrillation (a very fast and irregular contraction of the atria). (valleyhealth.com)
- Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. (wikipedia.org)
- Ventricular fibrillation is found initially in about 10% of people in cardiac arrest. (wikipedia.org)
- The ventricular muscle twitches randomly rather than contracting in a co-ordinated fashion (from the apex of the heart to the outflow of the ventricles), and so the ventricles fail to pump blood around the body - because of this, it is classified as a cardiac arrest rhythm, and patients in V-fib should be treated with cardiopulmonary resuscitation and prompt defibrillation. (wikipedia.org)
- Initial presentation was atrial fibrillation without the Brugada-type electrocardiogram, aborted cardiac arrest and positive family history of sudden death. (biomedsearch.com)
- He regained consciousness after 1 minute, though cardiac arrest from ventricular fibrillation was noted during an electroencephalography (EEG) examination. (neurology-jp.org)
- Sudden cardiac arrest (SCA) generally occurs as a result of an acute trigger that leads to ventricular tachycardia and/or fibrillation in the setting of an underlying cardiovascular abnormality that forms an arrhythmogenic substrate. (acc.org)
- The patient had a witnessed syncopal event, and prompt resuscitation in the field confirmed ventricular fibrillation (VF) as the cause of her cardiac arrest. (massgeneral.org)
Right ventricular outfl9
- Since the coronary angiography was normal, an electrophysiological study (EPS) consisting of a ventricular stimulation protocol from both me right ventricular apex as well as the right ventricular outflow tract was then performed. (redorbit.com)
- A long list of factors that can generate a Brugada ECG pattern have been described, including certain medications, electrolyte disturbances such as a decrease in the levels of potassium in the blood , and a reduction in blood supply to key areas of the heart, specifically the right ventricular outflow tract . (wikipedia.org)
- Despite initial reports of normal structural heart in majority of patients, recent reports showed frequent minor structural abnormalities, especially in the right ventricular outflow tract (RVOT) in these patients. (springer.com)
- The abnormalities found in the BrS patients were located in the right ventricular outflow tract (RVOT) and consisted of ST-segment elevation (STE), T-wave inversion, delayed activation, low amplitude, fractionation, delayed repolarization, and steep repolarization gradients. (acc.org)
- 2.] Gangadharan V, Sharma D, Ramu V Paul T Too Much Exercise: Right Ventricular Outflow Tract Tachycardia. (thefreedictionary.com)
- In our study, technique of the right ventricular outflow tract (RVOT) was a crucial step in the transatrialtranspulmonary repair of TOF, which could relieve the obstructive RVOT. (thefreedictionary.com)
- Out of these, 2 (0.95%) patients have aberrant course of right coronary artery close to the right ventricular outflow tract (RVOT) and in 2 (0.95%) patients left anterior descending artery was passing close to the RVOT. (thefreedictionary.com)
- This ruled out coronary anomalies and confirmed the presence of right ventricular outflow tract (RVOT) dilatation. (thefreedictionary.com)
- Turbulent flow of unknown origin was identified in the right ventricular outflow tract (RVOT) (Fig 2A). (thefreedictionary.com)
Terminating ventricular tachycardia1
- A 53-year-old woman presented with multiple episodes of ventricular fibrillation, a structurally normal heart and normal baseline electrocardiogram. (pagepressjournals.org)
- Subsequent electrocardiogram (ECG) revealed premature ventricular couplets with ST-segment elevation in V^sub 1^ and V^sub 2^ of the precordial leads with T-wave abnormalities. (redorbit.com)
- This case describes a 40-year-old active duty senior pilot who, while undergoing his annual flight physical examination, demonstrated a premature ventricular couplet (PVC) on screening electrocardiogram (ECG). (redorbit.com)
- Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation. (cdc.gov)
- An electrocardiogram (ECG) test can help detect Brugada pattern in such people. (medindia.net)
- We report the first case of lidocaine-induced Brugada electrocardiogram phenotype. (ahajournals.org)
- The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. (medsci.org)
Left ventricular noncompaction1
- Recently, epicardial mapping has revealed abnormal electrograms at the right ventricular (RV) outflow tract and inferior region of the right ventricle. (ahajournals.org)
- Monomorphic VA is classified on the basis of site of origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricular fascicles. (onlinejacc.org)
- Case of Ebstein anomaly complicated by left ventricular outflow tract obstruction secondary to deformed basal septum attributable to atrialized right ventricle. (thefreedictionary.com)
- Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. (thefreedictionary.com)
- Although, this patient exhibited eccentric left ventricular hypertrophy, such alteration is recognized as an uncommon finding in subjects diagnosed with aortic stenosis, which usually causes concentric hypertrophy secondary to the increased resistance imposed by the ventricular outflow tract obstruction. (thefreedictionary.com)
- It is named after the Catalan cardiologists Pedro and Josep Brugada who described the condition in 1992. (wikipedia.org)
- 1 In 1992, Brugada and Brugada 2 described 8 patients with unique ECG findings consisting of right bundle-branch block and ST-segment elevation in leads V 1 through V 3 , normal Q-T interval, and aborted cardiac death. (ahajournals.org)
- LQTS is a familial disease 1 2 characterized by abnormally prolonged ventricular repolarization and high risk of malignant ventricular tachyarrhythmias, often but not always occurring in the setting of high adrenergic activity, ie, physical or emotional stress. (ahajournals.org)
- 11 Acute myocardial ischemia leads to contraction band necrosis, infarction, and ultimately scar formation that forms an electrically unstable substrate for ventricular tachyarrhythmias. (acc.org)
- The interval from the peak to the end of the electrocardiographic (ECG) T wave (Tp-Te) can estimate cardiovascular mortality and ventricular tachyarrhythmias. (dovepress.com)
- 6 , 7 Furthermore, an increased Tp-Te interval could be a practical index to estimate cardiovascular mortality and ventricular tachyarrhythmias. (dovepress.com)
- Some patients are aware of virtually every premature ventricular beat, but others are unaware of even complex atrial or ventricular tachyarrhythmias. (merckmanuals.com)
- Ventricular fibrillation is more common in the setting of tachyarrhythmias (VT), bradycardia or asystole may happen if the conduction system is blocked by the heart attack, and EMD/PEA may be the result if the heart suffers severe damage. (medhelp.org)
- As a consequence, catheter ablation of sustained monomorphic VT is an important option to control recurrent ventricular tachycardias (VTs) but must be considered adjunctive to ICD placement, especially when structural heart disease is present. (clinicaladvisor.com)
- Of note is that Nademanee and colleagues ( Circulation 2011;123:1270-9) reported that epicardial catheter ablation at the anterior RVOT normalized the electrocardiographic abnormalities of BrS and prevented episodes of ventricular fibrillation. (acc.org)
- As the consequences, the importance of inhomogeneity of the cells in the sinus node, the validity of the ablation surgery for chronic atrial fibrillation and so on were indicated. (nii.ac.jp)
- This analysis shows that the benefits of dabigatran over a vitamin K antagonist in patients undergoing atrial fibrillation ablation are consistent across all geographic regions studied. (springermedizin.de)
- 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. (springermedizin.de)
- Dabigatran versus warfarin anticoagulation before and after catheter ablation for the treatment of atrial fibrillation. (healthtap.com)
- Dr. Huang is the Director of the electrophysiology section, and he specializes in treatment of patients with ventricular arrhythmias, especially ablation for ventricular tachycardia. (rochester.edu)
- Ventricular fibrillation is also seen in those with cardiomyopathy, myocarditis, and other heart pathologies. (wikipedia.org)
- Very frequent ventricular ectopy may also result in a cardiomyopathy in a minority of patients. (onlinejacc.org)
- Cardiovascular magnetic resonance imaging may be appropriate if echocardiography does not provide an accurate assessment of ventricular function, e.g., in arrhythmogenic right ventricular cardiomyopathy/dysplasia or sarcoidosis ( 1-5 ). (onlinejacc.org)
- Placement of the right precordial leads (V1 and V2) in a superior position (up to the second intercostal space) can increase the sensitivity of the ECG for detecting the Brugada phenotype in some patients,both in the presence or absence of a sodium block drug challenge. (clinicaladvisor.com)
- 3,4 Sodium channel blockers with slow dissociation kinetics such as flecainide and ajmaline are known to unmask the BrS ECG phenotype as well as precipitating ventricular tachycardia/fibrillation. (ahajournals.org)
- If a type 1 ECG is observed in the absence of any clinical criteria, this should be referred to as "idiopathic Brugada ECG pattern" and not as BS4. (escardio.org)
- 2013) has shown that in healthy individuals glucose by itself can prolong (with C-peptide antagonising the effects) the QT interval, which has long been used as a clinical index of the duration of ventricular repolarisation. (clinicaltrials.gov)
- The clinical presentation of proband was ventricular fibrillation. (go.jp)
- This article reviews the pharmacology, adverse effects and clinical evidence available to date on the use of dronedarone in the management of atrial fibrillation. (smw.ch)
- P-wave measurements are frequently used in clinical practice to predict atrial arrhythmias, especially atrial fibrillation (AF). (medsci.org)
Patients with atrial fibrillation2
- AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. (springermedizin.de)
- Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been recently approved by Swissmedic for management of patients with atrial fibrillation or atrial flutter. (smw.ch)
- Ventricular fibrillation (VFib) is a medical condition in which the heart beats in an abnormal rhythm. (differencebetween.net)
- This abnormal heart rhythm is known as ventricular fibrillation. (self.com)
- Hypokalemia and Ventricular Fibrillation- An ambulance EKG noted abnormal repolarisation with EKG presenting in a sinus rhythm with T wav. (medhelp.org)
- The Brugada electrocardiographic pattern is characterized by right bundle branch block morphology and ST segment elevations in the right precordial leads with an absence of identifiable underlying structural heart disease. (hindawi.com)
- We present the case of a 35-year-old male who presented with intestinal Shigellosis and was also found to have Brugada-type electrocardiographic changes on ECG. (hindawi.com)
- 3. Brugada J, Brugada R, Antzelevitch C, Towbin JA, Nademanee K, Brugada P:Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. (cogprints.org)
- This study was significant for STsegment elevation in V^sub 1^ and V^sub 2^ (Fig. 3), and the patient was referred to Dr. R. Brugada for further evaluation. (redorbit.com)
- Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3 : a marker for sudden death in patients without demonstrable structural heart disease. (springer.com)
- It is also important to be aware that some drugs (listed in table 3) may also produce a Brugada-like ST-segment elevation. (escardio.org)
- It is diagnosed by signature EKG changes including at least 2-mm J-point elevation with coved-type ST elevation and T-wave inversion in at least one right precordial leads (type I Brugada marker). (springer.com)
Atrial and ventricular2
Paroxysmal Atrial Fibri3
- More data are available for the arrhythmogenic effects of the SNS, which, when overactive, can trigger atrial and/or ventricular "adrenergic" arrhythmias in susceptible individuals (e.g. in patients with paroxysmal atrial fibrillation-PAF, ventricular pre-excitation, specific channelopathies, ischemic heart disease or cardiomyopathies), while it can also negate the protective anti-arrhythmic drug effects. (bvsalud.org)
- Pilsicainide (four patients) or flecainide (one patient) were administered orally for the treatment of symptomatic paroxysmal atrial fibrillation or premature atrial contractions. (bmj.com)
- 1. Case Report A 45-year-old man had visited his local hospital because of paroxysmal atrial fibrillation that had started 9 years earlier. (deepdyve.com)
- Monomorphic ventricular tachycardia (VT) in the presence of structural heart disease is largely attributed to anatomically bound macro-re-entry involving regions of myocardial scarring or the bundle branches. (onlinejacc.org)
- The overwhelming majority of VAs in patients without structural heart disease carry an excellent prognosis, and include premature ventricular complexes (PVCs), nonsustained VT, repetitive monomorphic VT, and sustained monomorphic VT. (onlinejacc.org)
- In another asymptomatic-patient group in whom an ECG that discloses the Brugada sign is performed for routine reasons such as a workup prior to surgery or sport license or screening for insurance, risk stratification to find the patients at high risk is needed because in most cases these patients have a benign prognosis3,22,23. (cogprints.org)
- 4, recommended that all asymptomatic patients with the Brugada sign should undergo an EP study for risk stratification, and, if inducible, an ICD should be implanted since Brugada et al.3, reported that an overall 8% life-threatening event rate was found in initially asymptomatic patients. (cogprints.org)
Structurally normal heart1
- Recent studies have confirmed a significant risk reduction in symptomatic patients with type 1 Brugada to as low as 0.8% to 3% with an implantable cardioverter defibrillator. (redorbit.com)
- Conclusion: Symptomatic patients displaying type 1 Brugada ECG (spontaneous or after sodium channel blockade) should receive an implantable cardioverter defibrillator and must be permanently disqualified. (redorbit.com)