Ajmaline

KCNE5

Gan-Xin Yan

List of circulatory system conditions

Masonic Medical Research Laboratory

Brugada syndrome

Ventricular fibrillation

Tachycardia

Catecholaminergic polymorphic ventricular tachycardia

Cardiac arrest

Charles Antzelevitch

Short QT syndrome

Management of atrial fibrillation

Flecainide

Cardiac transient outward potassium current

Heart arrhythmia

Electrocardiography

Frank I. Marcus

Ventricular tachycardia

Topera Medical

Ventricular tachycardia

Antiarrhythmic agent

KCNE2

Electrocardiography

Syncope (medicine)

List of OMIM disorder codes

Atrial fibrillation

Tachycardia

ANK2

कार्दियाक अरिदमिया

Ventricular tachycardia

Thyrotoxic periodic paralysis

Tricuspid valve stenosis

Arrhythmia

Long QT syndrome

Minimaze procedure

Syndrome206

• Idiopathic ventricular fibrillation can be caused by subclinical channelopathies such as Brugada syndrome. (pagepressjournals.org)
• The flecainide challenge test was positive for Brugada syndrome in two subjects in the case group and none in the control group. (pagepressjournals.org)
• The D1816fs/g98747-98748insT mutation in SCN5A may be associated with idiopathic ventricular fibrillation and Brugada syndrome with a broad phenotypic spectrum and incomplete penetrance. (pagepressjournals.org)
• IMSEAR at SEARO: Ventricular Fibrillation with Brugada Syndrome: A Case Report. (who.int)
• Brugada syndrome is a potentially lethal and eminently treatable entity that may present with palpitations or syncope. (who.int)
• This article presents the case of a young patient with Brugada syndrome and reviews key features in the epidemiology, pathophysiology, diagnosis, treatment and prognosis of this condition. (who.int)
• ABSTRACT Introduction: Brugada syndrome describes a subgroup of patients at risk for polymorphic ventricular tachycardia, ventricular fibrillation, and sudden cardiac death and is likely underdiagnosed among aviators. (redorbit.com)
• The Aeromedicai Consultation Service should review all cases of Brugada syndrome and render a return to fly for asymptomatic nondiagnostic Brugada types. (redorbit.com)
• Brugada syndrome refers to a disorder caused by defective cardiac ion channels and is characterized by the risk of developing polymorphic ventricular tachycardia (VT), ventricular fibrillation (VF), and death. (redorbit.com)
• Detailed cardiologic work-up eventually confirmed a diagnosis of type 1 Brugada syndrome. (redorbit.com)
• Considered a cardiac ion channel defect, type 1 Brugada syndrome carries a strong probability of permanent disqualification from aviation duties because of the risks associated with sudden cardiovascular incapacitation during flight. (redorbit.com)
• Most patients with Brugada syndrome are asymptomatic. (redorbit.com)
• This did not definitively confirm the diagnosis of Brugada syndrome, and hence a procainamide challenge was performed. (redorbit.com)
• Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm . (medlineplus.gov)
• Brugada syndrome usually becomes apparent in adulthood, although it can develop any time throughout life. (medlineplus.gov)
• Researchers have determined that SUNDS and Brugada syndrome are the same disorder. (medlineplus.gov)
• The exact prevalence of Brugada syndrome is unknown, although it is estimated to affect 5 in 10,000 people worldwide. (medlineplus.gov)
• Although Brugada syndrome affects both men and women, the condition appears to be 8 to 10 times more common in men. (medlineplus.gov)
• Brugada syndrome can be caused by mutations in one of several genes. (medlineplus.gov)
• A disruption in ion transport alters the way the heart beats, leading to the abnormal heart rhythm characteristic of Brugada syndrome. (medlineplus.gov)
• Mutations in other genes can also cause Brugada syndrome. (medlineplus.gov)
• Some of the additional genes involved in Brugada syndrome provide instructions for making proteins that ensure the correct location or function of sodium channels in heart muscle cells. (medlineplus.gov)
• In affected people without an identified gene mutation, the cause of Brugada syndrome is often unknown. (medlineplus.gov)
• Abnormally high blood levels of calcium (hypercalcemia) or potassium (hyperkalemia), as well as unusually low potassium levels (hypokalemia), also have been associated with acquired Brugada syndrome. (medlineplus.gov)
• Brugada syndrome ( BrS ) is a genetic disorder in which the electrical activity within the heart is abnormal. (wikipedia.org)
• The abnormal heart rhythms seen in those with Brugada syndrome often occur at rest. (wikipedia.org)
• About a quarter of those with Brugada syndrome have a family member who also has the condition. (wikipedia.org)
• There is no cure for Brugada syndrome. (wikipedia.org)
• While many of those with Brugada syndrome do not have any symptoms, Brugada syndrome may cause fainting or sudden cardiac death due to serious abnormal heart rhythms such as ventricular fibrillation or polymorphic ventricular tachycardia . (wikipedia.org)
• However, blackouts can occur in those with Brugada syndrome despite a normal heart rhythm due to a sudden drop in blood pressure, known as vasovagal syncope . (wikipedia.org)
• The abnormal heart rhythms seen in Brugada syndrome often occur at rest, following a heavy meal, or even during sleep. (wikipedia.org)
• Certain medications may also worsen the tendency to abnormal heart rhythms in patients with Brugada syndrome and should be avoided by these patients. (wikipedia.org)
• The individual cells of the heart communicate with each other with electrical signals, and these electrical signals are disrupted in those with Brugada syndrome. (wikipedia.org)
• The first mutations described in association with Brugada syndrome were in a gene responsible for a protein or ion channel that controls the flow of sodium ions through the cell membrane of heart muscle cells - the cardiac sodium channel . (wikipedia.org)
• Many of the genetic mutations that have subsequently been described in association with Brugada syndrome influence the sodium current in some way, or affect other ionic currents. (wikipedia.org)
• Mutations in SCN5A are reportedly linked to Brugada syndrome (BS), but recent observations suggest that they are not necessarily associated with ventricular fibrillation (VF) in BS patients. (cdc.gov)
• First described in 1992, Brugada syndrome is characterized by a specific electrocardiographic pattern in the right precordial leads and susceptibility to ventricular arrhythmias and sudden death. (revespcardiol.org)
• Brugada syndrome is included among the channelopathies, primary electrical disorders that, characteristically, are not associated with concomitant structural cardiac abnormalities. (revespcardiol.org)
• This article provides a summary of what is currently known about Brugada syndrome and an overview of the principal preclinical and clinical studies that have made the most significant contributions to our understanding of the condition. (revespcardiol.org)
• The syndrome of right bundle branch block, ST segment elevation and sudden cardiac death (SCD), better known today as Brugada syndrome, was described in 1992 as a new clinical and electrocardiographic syndrome involving susceptibility to ventricular arrhythmias and SCD in patients without obvious structural heart disease. (revespcardiol.org)
• 6-8 This review provides a summary of what is currently known about Brugada syndrome and up-to-date information from the main clinical and experimental studies published in recent years. (revespcardiol.org)
• With more patients with Brugada syndrome being identified, certain questions soon arose regarding the definition of its characteristic electrocardiographic (ECG) pattern and the diagnostic criteria for the disease. (revespcardiol.org)
• Although the 3 patterns can be observed in Brugada syndrome, and even in the same patient at different times, type I is the only one that is considered diagnostic of the disease, as specified in the 2 consensus documents published in 2002 and 2005. (revespcardiol.org)
• Electrocardiographic patterns (ECG) that can be found in the patients with Brugada syndrome. (revespcardiol.org)
• Brugada syndrome is included among the so-called channelopathies, that is, diseases produced by alterations in the transmembrane ion channels that participate in cell action potential, and which lead to an increased susceptibility to arrhythmias. (revespcardiol.org)
• In this case report, we characterize a novel inherited frameshift mutation c.4700_4701del (p.Phe1567Cysfs * 221) in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). (frontiersin.org)
• The Brugada syndrome (BrS) is characterized by a coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG) and an increased risk of sudden cardiac death (SCD). (frontiersin.org)
• Brugada syndrome is inherited as an autosomal dominant condition with incomplete penetrance. (frontiersin.org)
• Recently described syndromes such as the Brugada Syndrome may give clues to the underlying mechanism of ventricular arrhythmias. (wikipedia.org)
• In the Brugada syndrome, changes may be found in the resting ECG with evidence of right bundle branch block (RBBB) and ST elevation in the chest leads V1-V3, with an underlying propensity to sudden cardiac death. (wikipedia.org)
• The differential diagnosis of cardiac arrest in an otherwise presumably healthy subject is varied, but it includes such entities as acute cardiac ischemia due to atherosclerosis or coronary anomaly, hypertrophic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, long QT syndrome, and arrhythmogenic right ventricular cardiomyopathy (ARVC). (medscape.com)
• Incidence, clinical implications and prognosis of atrial arrhythmias in Brugada syndrome. (medscape.com)
• Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome. (medscape.com)
• Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. (medscape.com)
• Brugada J, Brugada R, Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. (medscape.com)
• Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. (medscape.com)
• Vorobiof G, Kroening D, Hall B, Brugada R, Huang D. Brugada syndrome with marked conduction disease: dual implications of a SCN5A mutation. (medscape.com)
• Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. (medscape.com)
• Alings M, Wilde A. "Brugada" syndrome: clinical data and suggested pathophysiological mechanism. (medscape.com)
• Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? (medscape.com)
• Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome. (medscape.com)
• Antzelevitch C, Brugada P, Brugada J, Brugada R. Brugada syndrome: from cell to bedside. (medscape.com)
• Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation. (medscape.com)
• An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. (medscape.com)
• What is Brugada Syndrome? (medindia.net)
• Brugada syndrome (BrS) is a recently identified disorder. (medindia.net)
• Brugada syndrome is a rare but serious heart condition that affects the way electrical signals pass through the heart. (medindia.net)
• Spanish cardiologists Pedro Brugada and Joseph Brugada reported it as a distinct clinical syndrome in 1992. (medindia.net)
• Brugada syndrome (BrS) is a rare genetic heart disorder characterized by an abnormal electrocardiogram [ECG] due to ventricular arrhythmias. (medindia.net)
• Brugada syndrome is characterized by the presence of ST-segment elevation in leads V 1 to V 3 . (medindia.net)
• Many people who have Brugada syndrome are apparently asymptomatic, have structurally normal hearts and are unaware of their condition. (medindia.net)
• Studies indicate that Brugada syndrome is responsible for 4%-12% of unexpected sudden deaths and for up to 20% of all sudden deaths in apparently normal individuals with no previous heart conditions. (medindia.net)
• The average age of persons afflicted with Brugada syndrome is 35-40 years. (medindia.net)
• Brugada syndrome has been found to be more prevalent among males. (medindia.net)
• Brugada syndrome is clinically related with sudden and unexpected death syndrome (SUDS), sudden unexpected nocturnal death syndrome (SUNDS) and sudden infant death syndrome (SIDS). (medindia.net)
• According to the National Institutes of Health it is estimated that 5 in 10,000 people worldwide are affected by the Brugada syndrome. (medindia.net)
• As awareness of Brugada syndrome increases among medical fraternity and public it can be expected that the number of identifiable cases worldwide will also increase. (medindia.net)
• What is the Genetics behind Brugada Syndrome? (medindia.net)
• Brugada syndrome predominantly has a genetic cause. (medindia.net)
• The primary gene associated with Brugada syndrome is located on chromosome 3 and is known as the SCN5A gene. (medindia.net)
• Approximately 15%-30% of individuals with Brugada syndrome have a SCN5A gene mutation. (medindia.net)
• These genes have varying mechanisms and expressions associated with Brugada Syndrome. (medindia.net)
• What are the Causes of Brugada syndrome? (medindia.net)
• Brugada syndrome is mostly inherited as an autosomal dominant. (medindia.net)
• What are the Signs & Symptoms of Brugada syndrome? (medindia.net)
• Cardiac events in patients with Brugada syndrome (BS) typically occur at rest and mainly during sleep, suggesting that changes in autonomic modulation play an important role in the arrhythmogenesis of the disease. (springer.com)
• Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. (springer.com)
• Gender differences in clinical manifestations of Brugada syndrome. (springer.com)
• Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. (springer.com)
• The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. (springer.com)
• Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways. (springer.com)
• Cardiac autonomic dysfunction in Brugada syndrome. (springer.com)
• Brugada syndrome (BrS) is a clinical entity first described in 1992. (frontiersin.org)
• Background -Mutations in the gene encoding the human cardiac Na + channel α-subunit (hH1) are responsible for chromosome 3-linked congenital long-QT syndrome (LQT3) and idiopathic ventricular fibrillation (IVF). (ahajournals.org)
• This is now called the Brugada syndrome and represents a distinct syndrome of IVF. (ahajournals.org)
• The clinical features of the Brugada syndrome can be attributed to early repolarization, depolarized areas of right ventricular myocardium, or focal right ventricular conduction abnormalities. (ahajournals.org)
• Recent genetic studies have confirmed that the Brugada syndrome and chromosome 3-linked congenital long-QT syndrome (LQT3) are allelic disorders of the cardiac Na + channel α-subunit gene ( SCN5A , 3p21). (ahajournals.org)
• 4 5 At present, 3 SCN5A mutations have been demonstrated in the Brugada syndrome: a splice-donor mutation, a frame-shift mutation, and a missense mutation. (ahajournals.org)
• 5 It is not clear, however, whether these rather subtle functional defects of T1620M are sufficient to cause ECG abnormalities and predisposition to lethal ventricular arrhythmias in Brugada syndrome patients or whether some other factors involved in the functional association with mutant channel molecules may give rise to aggravation of the biophysical abnormality in vivo. (ahajournals.org)
• Although the estimated prevalence of the Brugada Syndrome makes it a rare disease - it ranges from 1-5/10 000 in Europe to 12/ 10 000 inhabitants in Southeast Asia, the implied risk of a tragic and preventable event - sudden death - in young and, otherwise, healthy individuals has attracted great interest from scientists all over the world. (escardio.org)
• Brugada syndrome (BS), first described in 1992, is an inherited arrhythmogenic disease, characterised by coved-type ST-segment elevation in right precordial leads and an increased risk of sudden cardiac death (SCD), due to ventricular fibrillation (VF)1. (escardio.org)
• Background- Fragmented QRS complexes (fQRS) in the right precordial leads are associated with occurrence of ventricular fibrillation (VF) in Brugada syndrome. (ahajournals.org)
• Methods and Results- We evaluated the existence of fQRS in 456 patients with Brugada syndrome, including 117 patients with syncope and 23 patients with VF. (ahajournals.org)
• Conclusions- The distribution of fQRS is associated with prognosis in Brugada syndrome, further supporting the association of fQRS and arrhythmia substrate. (ahajournals.org)
• fQRS in the right precordial leads represents electrophysiological abnormality of the right ventricular outflow tract (RVOT) and is associated with lethal arrhythmic events in patients with Brugada syndrome. (ahajournals.org)
• Epicardial mapping and ablation have revealed that the existence of delayed potential on the epicardium of RVOT is a substrate of ECG change and ventricular arrhythmia in Brugada syndrome, and it is also recorded outside of RVOT region. (ahajournals.org)
• It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome. (wikipedia.org)
• Brugada syndrome is a genetic disease that result in mutations in the sodium ion channel (gene SCN5A) of the myocytes in the heart. (wikipedia.org)
• Brugada syndrome can result in ventricular fibrillation and potentially death. (wikipedia.org)
• While the characteristic patterns of Brugada syndrome on an electrocardiogram may be seen regularly, often the abnormal pattern is only seen spontaneously due to unknown triggers or after challenged by particular drugs. (wikipedia.org)
• Ajmaline is used intravenously to test for Brugada syndrome since they both affect the sodium ion channel. (wikipedia.org)
• Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. (nih.gov)
• I. Brugada Syndrome: What every physician needs to know. (clinicaladvisor.com)
• Brugada syndrome is characterized by a coved-type ST segment elevation in the right precordial leads of the electrocardiogram (ECG) and isassociated with a relatively high risk of sudden cardiac death due to ventricular fibrillation (VF) without major structural heart disease. (clinicaladvisor.com)
• Since its introduction, the Brugada syndrome has attracted great interest because of its high incidence in many parts of the world and its association with high risk of sudden death in young and otherwise healthy adults, and less frequently in infants and children. (clinicaladvisor.com)
• Diagnostic Confirmation: Are you sure your patient has Brugada Syndrome? (clinicaladvisor.com)
• Type 1 or coved-type ST segment elevation, characterized by a J point elevation of ≥2 mm (0.2 mV) followed by a negative or isoelectric T wave, is diagnostic of Brugada syndrome. (clinicaladvisor.com)
• ECG of Brugada syndrome. (clinicaladvisor.com)
• Differential diagnosis of the Brugada syndrome must be approached with care since ST segment elevation is associated with a wide variety of conditions. (clinicaladvisor.com)
• Worldwide prevalence of Brugada syndrome is estimated to be 1 in 10,000, but is much higher in Asian and Southeast Asian countries, reaching 5 to 10 in 10,000 and much lower in some Eastern European countries like Denmark, with an estimated prevalence of 1.1 in 100,000. (clinicaladvisor.com)
• The frequency is higher (≥5 per 10,000) in Southeast Asia, especially Thailand and the Philippines where the Brugada syndrome is considered to be the major cause of sudden death in young individuals. (clinicaladvisor.com)
• In Japan, type-1 ST segment elevation diagnostic of Brugada syndrome was observed in 12 per 10,000 inhabitants, whereas type-2 and type-3 ECG were much more prevalent, appearing in 58 per 10,000 inhabitants. (clinicaladvisor.com)
• Since it was first described approximately 15 years ago, the Brugada Syndrome has spurred a significant quantity of interest in its underlying mechanism and physiology. (hindawi.com)
• The syndrome is clinically significant since these patients are at a higher risk of developing malignant ventricular arrhythmias. (hindawi.com)
• Electrocardiogram performed on arrival ( Figure 1 ) suggested possible Brugada syndrome. (revespcardiol.org)
• Forty-eight hours later he complained of productive cough with yellowish sputum and shortness of breath and spiked a fever of 38.3 °C. A repeat electrocardiogram was once again compatible with Brugada syndrome ( Figure 3 ). (revespcardiol.org)
• Recent data suggest that loss of the action potential dome in right ventricular epicardium but not endocardium underlies the ST segment elevation seen in the Brugada syndrome (9-10). (fac.org.ar)
• In addition to a prolonged QT interval, which occurs in some but not all persons with long QT syndrome, another characteristic electrocardiographic abnormality is the so-called Brugada sign (an upward deflection of the terminal portion of the QRS complex). (aafp.org)
• SADS encompasses a number of clinical entities, including congenital long QT syndrome, Wolff-Parkinson-White syndrome, idiopathic ventricular fibrillation, and coronary artery spasm (e.g., from cocaine intoxi cation). (aafp.org)
• In patients who undergo aborted sudden cardiac death or syncope of unknown origin (symptomatic Brugada syndrome), no one argues that the implantation of an ICD is the first-line therapy regardless of the findings of the EP study. (cogprints.org)
• 11, performed EP-guided medical therapy in 34 patients with idiopathic VF, in 5 of whom the criterion of Brugada syndrome were fulfilled, and reported excellent long-term results. (cogprints.org)
• An EP study is usually used to examine the preventive effects of antiarrhythmic agents on sustained ventricular tachycardia in patients with structural heart disease, whereas the prognostic value of the EP study in predicting life-threatening events in Brugada syndrome is still controversial. (cogprints.org)
• 23 failed to find an association between the inducibility and recurrence of VT/VF in patients with Brugada syndrome regardless of whether it was symptomatic or asymptomatic. (cogprints.org)
• In patients with asymptomatic Brugada syndrome who are family members of symptomatic Brugada syndrome patients, the same strategy as that for the symptomatic Brugada syndrome patients should be considered 2,3,4. (cogprints.org)
• Brugada syndrome was first reported as a distinct entity in 1992. (springer.com)
• Initially thought of as a rare entity, Brugada syndrome is now widely recognized as a common cause of natural death among young men as a result of ventricular arrhythmia occurring at rest, particularly during sleep. (springer.com)
• However, mutation in a single gene could be implicated in less than 30% of patients with Brugada syndrome, and a recent study showing association of this disease with common single nucleotide polymorphism of SCN5A , SCN10A , and HEY2 pointed toward polygenic or oligogenic pattern of inheritance rather than a single gene defect. (springer.com)
• Brugada syndrome is now viewed as a spectrum of cardiomyopathy as well as channelopathy. (springer.com)
• The pathophysiologic underlying cardiac arrhythmia in Brugada syndrome is still unresolved with continued debate on depolarization versus repolarization defect. (springer.com)
• The authors would like to thank the National Research Council of Thailand (NRCT) for support on the study of Brugada syndrome. (springer.com)
• Adler A. Brugada syndrome: diagnosis, risk stratification, and management. (springer.com)
• Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, Nakazawa K, Kimura A, Hiraoka M. A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. (springer.com)
• Brugada syndrome is a heart condition that causes a disruption of the normal rhythm in the heart's lower chambers (ventricular arrhythmia). (nih.gov)
• Brugada syndrome may be caused by a mutation in any of at least 16 genes (most commonly the SCN5A gene) and is inherited in an autosomal dominant manner. (nih.gov)
• In some cases, the cause of Brugada syndrome is unknown. (nih.gov)
• While symptoms of Brugada syndrome usually develop in adulthood, they can develop at any age. (nih.gov)
• Sudden cardiac arrest may be the initial symptom of Brugada syndrome in as many as one-third of affected people. (nih.gov)
• The genetic form of Brugada syndrome (not the acquired form) is inherited in an autosomal dominant manner. (nih.gov)
• Almost all people with Brugada syndrome have a parent with the condition. (nih.gov)
• Some arrhythmias are congenital such as Long QT Syndrome (LQTS), Brugada Syndrome (BrS), atrial fibrillation e.t.c. (exclusivepapers.com)
• Brugada syndrome (BrS) is an autosomal dominant inherited disorder caused by mutations mainly in the SCN5A gene. (go.jp)
• This is a report of a child with Brugada syndrome who experienced ventricular fibrillation storm. (biomedsearch.com)
• A 35-year-old man showed a convulsive attack with consciousness loss and was suspected of having Brugada syndrome 6 months prior to admission to our hospital. (neurology-jp.org)
• The patient was diagnosed with Brugada syndrome and received implantable cardioverter defibrillator (ICD). (neurology-jp.org)
• Brugada syndrome is an inheritable cardiac disease causing sudden death by ventricular fibrillation. (neurology-jp.org)
• The patient did not have typical ECG findings of Brugada syndrome. (snpedia.com)
• PMID 11827685 ] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease. (snpedia.com)
• PMID 17141278 ] A novel mutation in the SCN5A gene is associated with Brugada syndrome. (snpedia.com)
• Abstract -Mutations in SCN5A , the gene encoding the cardiac Na + channel, have been identified in 2 distinct diseases associated with sudden death: one form of the long-QT syndrome (LQT 3 ) and the Brugada syndrome. (ahajournals.org)
• LQT 3 and Brugada syndrome are allelic disorders but may also share a common genotype. (ahajournals.org)
• SCN5A, the gene that encodes the human cardiac Na + channel α subunit, 1 is mutated in one form of the long-QT syndrome (LQT 3 ) and in Brugada syndrome. (ahajournals.org)
• 5 6 QT intervals have been reported to be normal in patients with Brugada syndrome. (ahajournals.org)
• 10 Although functional abnormalities have been described for Brugada syndrome-related SCN5A mutant channels, 3 11 the mechanism(s) whereby these explain the Brugada phenotype are less clear. (ahajournals.org)
• In this study we present clinical and genetic data of a single large SCN5A -linked family, phenotypically characterized by nocturnal death and electrocardiographically by both LQT 3 and Brugada syndrome features in the same patients. (ahajournals.org)
• We show that LQT 3 and the Brugada syndrome are more closely related than heretofore appreciated and can even be caused by the same mutation. (ahajournals.org)
• PAF, Brugada syndrome, idiopathic ventricular fibrillation). (bvsalud.org)
• What is the arrhythmogenic substrate in the Brugada Syndrome (BrS)? (acc.org)
• Brugada syndrome has been linked to mutations in SCN5A. (ahajournals.org)
• Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. (ahajournals.org)
• Lidocaine, an agent with rapid dissociation kinetics, has previously been shown to exert no effect in patients with Brugada syndrome. (ahajournals.org)
• We characterized a novel double mutation of SCN5A (V232I in DI-S4+L1308F in DIII-S4) identified in a rare case of lidocaine (1 mg/kg)-induced Brugada syndrome. (ahajournals.org)
• Brugada syndrome (BrS) is an inherited cardiac disease characterized by an ST segment elevation in the right precordial electrocardiogram (ECG) leads (V1 to V3) and a high incidence of sudden death. (ahajournals.org)
• We report a 6-month-old Japanese infant with a malignant form of Brugada syndrome, who had frequent episodes of ventricular fibrillation (VF) and nonsustained polymorphic ventricular tachycardia (VT). (nih.gov)
• To the best of our knowledge, this infant is the youngest patient reported to have Brugada syndrome. (nih.gov)
• Journal Article] Lack of genotype-phenotype correlation in Brugada syndrome and sudden arrhythmic death syndrome families with reported pathogenic SCN1B variants. (nii.ac.jp)
• Polymorphic ventricular tachycardia (VT) is rare and generally occurs in patients with genetic ion channel disorders including long QT syndrome, Brugada syndrome, catecholaminergic polymorphic VT, and short QT syndrome. (onlinejacc.org)
• Another fascinating area, idiopathic ventricular fibrillation and early repolarization syndrome, are undergoing research for a genetic basis. (onlinejacc.org)
• This disease is now frequently called "Brugada syndrome" (BrS). (biomedcentral.com)
• Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. (thefreedictionary.com)
• Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent? (medscape.com)
• 2010). Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs Brugada syndrome. (springermedizin.de)
• The recommendations focus on genetic testing for 13 inherited cardiac conditions including: Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Brugada Syndrome, Progressive Cardiac Conduction Disease, Short QT Syndrome, Atrial Fibrillation, Hypertrophic Cardiomyopathy, Arrhythmogenic Cardiomyopathy/Arrhythmogenic Right Ventricular Cardiomyopathy, Dilated Cardiomyopathy, Left Ventricular Noncompaction and Restrictive Cardiomyopathy. (scienceblog.com)
• Other etiologies that carry an increased risk of VF include various cardiomyopathies, the Brugada syndrome, drowning, metabolic abnormalities such as acidosis or hypokalemia, and side effects of medications that affect membrane ion conductance channels. (massgeneral.org)
• Besides long QT syndrome, other abnormalities of the heart's electrical system, such as Brugada syndrome, can cause sudden death. (self.com)
• Electrocardiographic changes were evaluated retrospectively in five patients without previous episodes of syncope or ventricular fibrillation who developed abnormal ST segment elevation mimicking the Brugada syndrome in leads V1-V3 after the administration of class Ic antiarrhythmic drugs. (bmj.com)
• In 1992, Brugada and Brugada 1 reported a study of eight patients with idiopathic ventricular fibrillation who showed ST segment elevation in the right precordial lead (the Brugada syndrome). (bmj.com)
• Recent studies 2-4 have reported that class I antiarrhythmic drugs such as flecainide, procainamide, and ajmaline could unmask ST segment elevation in patients with "latent" Brugada syndrome. (bmj.com)
• In addition, we reported the first case 5 of a patient who had no previous syncope or ventricular fibrillation, but who showed electrocardiographic changes mimicking those of the Brugada syndrome after administration of a class Ic antiarrhythmic drug. (bmj.com)
• Serious cardiac causes include myocardial ischemia or other myocardial disorders, congenital heart disease (eg, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, congenital long QT syndrome ), valvular heart disease , and conduction system disturbances (eg, disturbances that cause bradycardia or heart block ). (merckmanuals.com)
• Brugada syndrome is an example of a channelopathy caused by an alteration in the transmembrane ion currents that together constitute the cardiac action potential. (rcpjournals.org)
• Approximately 20% of the cases of Brugada syndrome have been shown to be associated with mutations in the gene coding for the sodium ion channel in the cell membranes of the muscle cells of the heart. (rcpjournals.org)
• Patients with Brugada syndrome are prone to develop ventricular tachyarrhythmias that may lead to syncope, cardiac arrest or sudden cardiac death. (rcpjournals.org)
• Many clinical situations have been reported to unmask or exacerbate the electrocardiography (ECG) pattern of Brugada syndrome. (rcpjournals.org)
• Genetic testing for Brugada syndrome is clinically available. (rcpjournals.org)
• Here we report two cases of Brugada syndrome followed by a comprehensive review of the literature. (rcpjournals.org)
• Brugada syndrome, an autosomal dominant condition, is a disorder characterised by sudden death associated with one of several ECG patterns characterised by incomplete right bundle-branch block and ST-segment elevations in the anterior precordial leads. (rcpjournals.org)
• At present, implantation of an automatic implantable cardiac defibrillator (ICD) is the only treatment proven effective in treating ventricular tachycardia and fibrillation and preventing sudden death in patients with Brugada syndrome. (rcpjournals.org)
• Brugada syndrome (BS), first described in 1992, 1 is a major cause of sudden cardiac death (SCD), 2 syncope and ventricular tachyarrhythmia in young people with no structural heart disease. (rcpjournals.org)
• The syndrome should be suspected in patients with documented idiopathic ventricular fibrillation, self-terminating polymorphic ventricular tachycardia, a family history of sudden cardiac death in a young person and/or syncope with the characteristic electrocardiography (ECG) changes. (rcpjournals.org)
• His repeat ECG showed RBBB with ST elevation in V1 to V2, suggesting Brugada syndrome Type 1 ( Fig 1c ). (rcpjournals.org)
• A sodium-channel blocker infusion test did not result in the typical ECG pattern of Brugada syndrome (BS), and the test attenuated J-point elevation in the inferolateral leads. (deepdyve.com)
• It may be important in cases of high suspicion for transient or concealed Brugada syndrome to detect Brugada when it does NOT show in the 4th intercostal space. (blogspot.com)
• I am an expert in cardiac arrhythmias - with particular expertise in the ablation of persistent atrial fibrillation, ventricular tachycardia and epicardial ablations including Brugada syndrome. (healthtap.com)
• He specializes in cardiac electrophysiology, and specializes in heart rhythm disorders, ranging from slow heart rhythms to irregular heart beats to fast heart rhythms, such as atrial fibrillation, atrial flutter, supraventricular arrhythmias, Wolff-Parkinson-White syndrome, ventricular tachycardia, and ventricular fibrillation. (utah.edu)
• Dr. Han also diagnoses and treats a variety of heart rhythm disorders that occur as a result of coronary artery disease, congenital heart disease, cardiac sarcoidosis, long QT syndrome, hypertrophic cardiomyopathy (HOCM), Brugada syndrome, and arrhythmogenic right ventricular dysplasia (ARVD). (utah.edu)
• Various arrhythmias are discussed in detail, from tachycardia and bradycardia to cardiomyopathy and Brugada Syndrome. (whsmith.co.uk)

Idiopathic ventricular11

• Our objective is to study the clinical behaviour of a new SCN5A mutation found in a woman with idiopathic ventricular fibrillation. (pagepressjournals.org)
• Genetic testing may be useful to identify the etiology of idiopathic ventricular fibrillation in patients with a negative thorough clinical evaluation. (pagepressjournals.org)
• Novel SCN5A mutation associated with idiopathic ventricular. (pagepressjournals.org)
• It is also notable that ventricular fibrillation occurs where there is no discernible heart pathology or other evident cause, the so-called idiopathic ventricular fibrillation. (wikipedia.org)
• Idiopathic ventricular fibrillation occurs with a reputed incidence of approximately 1% of all cases of out-of-hospital arrest, as well as 3%-9% of the cases of ventricular fibrillation unrelated to myocardial infarction, and 14% of all ventricular fibrillation resuscitations in patients under the age of 40. (wikipedia.org)
• It follows then that, on the basis of the fact that ventricular fibrillation itself is common, idiopathic ventricular fibrillation accounts for an appreciable mortality. (wikipedia.org)
• Idiopathic ventricular fibrillation (IVF) is a clinical disorder characterized by development of ventricular fibrillation without obvious structural heart disease. (ahajournals.org)
• On the other hand, there is the group of symptomatic patients who have been diagnosed as suffering syncopal episodes of unknown cause, or vaso-vagal origin, or have a diagnosis of idiopathic ventricular fibrillation. (fac.org.ar)
• OMIM 601144), or "Idiopathic ventricular fibrillation" as defined by some authors [ 1 ], is an autosomal dominant form of cardiac arrhythmia, presenting with a typical electrocardiographic (ECG) pattern of ST segment elevation in leads V1 to V3, and incomplete or complete right bundle branch block [ 2 ]. (biomedcentral.com)
• While some individuals were asymptomatic, other presentations included left ventricular non-compaction, a resuscitated cardiac arrest due to idiopathic ventricular fibrillation, dilated cardiomyopathy, and sudden unexplained death. (biomedcentral.com)
• This study describes the clinical and genetic investigations of an Australian family with marked cardiac phenotype heterogeneity among four individuals, including left ventricular non-compaction (LVNC), idiopathic ventricular fibrillation, DCM and sudden unexplained death, which lent itself to the application of exome sequencing to identify a pathogenic mutation. (biomedcentral.com)

Sudden cardi8

• Play media Ventricular fibrillation is a cause of cardiac arrest and sudden cardiac death. (wikipedia.org)
• BrS is characterized by ST-segment elevations in the right precordial leads and susceptibility to ventricular arrhythmias and sudden cardiac death. (frontiersin.org)
• After diagnosis, specific tests may provide an estimate of the risk of ventricular arrhythmias and sudden cardiac death in each person. (nih.gov)
• Sustained ventricular arrhythmias are the most common cause of sudden cardiac death. (clinicaladvisor.com)
• The most common causes of sudden cardiac death in athletes are hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. (bcmj.org)
• There are many specific causes of sudden cardiac death from heart rhythm disorders (usually ventricular tachycardia or ventricular fibrillation) in apparently healthy young individuals. (cmaj.ca)
• A novel clinical entity characterized by ST segment elevation in right precordial leads (V1 to V3), incomplete or complete right bundle branch block, and susceptibility to ventricular tachyarrhythmia and sudden cardiac death has been described by Brugada et al . (biomedcentral.com)
• Simple question for the specialists: in cases of sudden cardiac death, are they all preceded by ventricular fibrillation, or sometimes the heart simply stops beating suddenly without VF? (medhelp.org)

Arrhythmia16

• Specifically, this disorder can lead to irregular heartbeats in the heart's lower chambers (ventricles), which is an abnormality called ventricular arrhythmia. (medlineplus.gov)
• The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered from supraventricular tachycardia. (frontiersin.org)
• SCD is frequently caused by an abrupt change in heart rhythm (arrhythmia), most often ventricular tachycardia (VT) or ventricular fibrillation (VF), that impairs cardiac pumping, thereby depriving vital organs of oxygenated blood. (jci.org)
• The most common type of arrhythmia is atrial fibrillation, which causes an irregular and fast heart beat. (patientsville.com)
• Avoiding medications and/or conditions that predispose the patient to ventricular arrhythmia is advised in all patients. (springer.com)
• RF ablation of the epicardial substrate in the RVOT has been shown to prevent recurrence of ventricular arrhythmia in severe cases. (springer.com)
• Atrial fibrillation (AF) is the most common arrhythmia, with a prevalence of 0.4% to 1% in the general population, increasing to 8% in those older than 80 years. (clinicaladvisor.com)
• This very fast and polymorphic arrhythmia is most consistent with ventricular fibrillation. (cmaj.ca)
• Silent brain infarctions, microemboli and microbleeds, brain atrophy, cerebral hypoperfusion from widely fluctuating ventricular rates, altered hemostatic function, vascular oxidative stress, and inflammation may all exacerbate CI, particularly in patients with persistent/permanent rather than paroxysmal AF and with increased duration/burden of the arrhythmia. (bvsalud.org)
• While older studies had indicated supraventricular tachycardia as the most common tachyarrhythmia in pregnancy, more recent data indicate an increase in the frequency of arrhythmias, with atrial fibrillation (AF) emerging as the most frequent arrhythmia in pregnancy, attributed to an increase in maternal age, cardiovascular risk factors and CHD in pregnancy. (bvsalud.org)
• Emerging evidence in patients with ventricular fibrillation (VF) in a variety of clinical scenarios implicates an important role for triggers originating from the distal Purkinje arborization in the initiation of this malignant arrhythmia ( 10-14 ). (onlinejacc.org)
• Ventricular arrhythmia (VA) in structurally normal hearts can be broadly considered under non-life-threatening monomorphic and life-threatening polymorphic rhythms. (onlinejacc.org)
• Patients with ventricular arrhythmia (VA) require an evaluation to determine if structural heart disease is present ( 1 ). (onlinejacc.org)
• Life-threatening ventricular arrhythmia and Brugada-type ST-segment elevation associated with acute ischemia of the right ventricular outflow tract ," Circulation Journal, vol. (thefreedictionary.com)
• Atrial fibrillation is a common arrhythmia associated with increased cardiovascular mortality and morbidity including stroke, heart failure and hospitalisations. (smw.ch)
• Atrial fibrillation (AF), the most common arrhythmia, affects approximately 1-1.5% of the population. (smw.ch)

Polymorphic6

• Polymorphic ventricular tachycardia (PVT). (escardio.org)
• Objectives The goal of this study was to describe the mapping and ablation of polymorphic ventricular tachycardia (VT) after myocardial infarction (MI). (onlinejacc.org)
• age 61 ± 7 years) with recurrent episodes of polymorphic VT after anterior MI (left ventricular ejection fraction 32 ± 7%) despite revascularization and antiarrhythmic drugs were studied. (onlinejacc.org)
• All patients demonstrated frequent ventricular premature beats (PBs) initiating polymorphic VT. (onlinejacc.org)
• Coronary angiography can be useful to exclude coronary heart disease in patients with life-threatening VAs such as polymorphic ventricular tachycardia (PMVT) ( 1 ). (onlinejacc.org)
• Syncope, typically occurring at rest or during sleep, is a common presentation of BrS [ 3 ], and it is caused by fast polymorphic ventricular tachycardia. (biomedcentral.com)

Syncope5

• Discussion: Special care must be taken if ECG demonstrates a Brugada pattern-especially in patients with a history of syncope or a family history of sudden death. (redorbit.com)
• A publication has reported that the minor (and quite rare) T allele of rs137854604 was seen in a 39-year-old Japanese patient who was admitted to the hospital for recurrent syncope and suffered an episode of spontaneous ventricular fibrillation while hospitalized. (snpedia.com)
• This study included five patients (four male and one female) without previous syncope or ventricular fibrillation who showed ST segment elevation in the right precordial leads following administration of class Ic drugs (table 1 ). (bmj.com)
• There was no family history of life threatening ventricular arrhythmias, syncope, or sudden death in any of the patients. (bmj.com)
• Paroxysmal supraventricular and ventricular tachycardias (occasional episodes of very rapid heartbeat above or in the ventricles, that start and stop suddenly) - Supraventricular arrhythmias with extreme fast heart rates, even though non-life threatening, can cause hemodynamic (blood flow) compromise with syncope such as atrial fibrillation (a very fast and irregular contraction of the atria). (valleyhealth.com)

Cardiac arrest7

• Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. (wikipedia.org)
• Ventricular fibrillation is found initially in about 10% of people in cardiac arrest. (wikipedia.org)
• The ventricular muscle twitches randomly rather than contracting in a co-ordinated fashion (from the apex of the heart to the outflow of the ventricles), and so the ventricles fail to pump blood around the body - because of this, it is classified as a cardiac arrest rhythm, and patients in V-fib should be treated with cardiopulmonary resuscitation and prompt defibrillation. (wikipedia.org)
• Initial presentation was atrial fibrillation without the Brugada-type electrocardiogram, aborted cardiac arrest and positive family history of sudden death. (biomedsearch.com)
• He regained consciousness after 1 minute, though cardiac arrest from ventricular fibrillation was noted during an electroencephalography (EEG) examination. (neurology-jp.org)
• Sudden cardiac arrest (SCA) generally occurs as a result of an acute trigger that leads to ventricular tachycardia and/or fibrillation in the setting of an underlying cardiovascular abnormality that forms an arrhythmogenic substrate. (acc.org)
• The patient had a witnessed syncopal event, and prompt resuscitation in the field confirmed ventricular fibrillation (VF) as the cause of her cardiac arrest. (massgeneral.org)

Right ventricular outfl9

• Since the coronary angiography was normal, an electrophysiological study (EPS) consisting of a ventricular stimulation protocol from both me right ventricular apex as well as the right ventricular outflow tract was then performed. (redorbit.com)
• A long list of factors that can generate a Brugada ECG pattern have been described, including certain medications, electrolyte disturbances such as a decrease in the levels of potassium in the blood , and a reduction in blood supply to key areas of the heart, specifically the right ventricular outflow tract . (wikipedia.org)
• Despite initial reports of normal structural heart in majority of patients, recent reports showed frequent minor structural abnormalities, especially in the right ventricular outflow tract (RVOT) in these patients. (springer.com)
• The abnormalities found in the BrS patients were located in the right ventricular outflow tract (RVOT) and consisted of ST-segment elevation (STE), T-wave inversion, delayed activation, low amplitude, fractionation, delayed repolarization, and steep repolarization gradients. (acc.org)
• 2.] Gangadharan V, Sharma D, Ramu V Paul T Too Much Exercise: Right Ventricular Outflow Tract Tachycardia. (thefreedictionary.com)
• In our study, technique of the right ventricular outflow tract (RVOT) was a crucial step in the transatrialtranspulmonary repair of TOF, which could relieve the obstructive RVOT. (thefreedictionary.com)
• Out of these, 2 (0.95%) patients have aberrant course of right coronary artery close to the right ventricular outflow tract (RVOT) and in 2 (0.95%) patients left anterior descending artery was passing close to the RVOT. (thefreedictionary.com)
• This ruled out coronary anomalies and confirmed the presence of right ventricular outflow tract (RVOT) dilatation. (thefreedictionary.com)
• Turbulent flow of unknown origin was identified in the right ventricular outflow tract (RVOT) (Fig 2A). (thefreedictionary.com)

Terminating ventricular tachycardia1

• Ajmaline was seen to be more effective than lidocaine (an accepted drug for treatment) in terminating ventricular tachycardia for acute treatment or emergency therapy for people with recurring symptoms. (wikipedia.org)

Electrocardiogram7

• A 53-year-old woman presented with multiple episodes of ventricular fibrillation, a structurally normal heart and normal baseline electrocardiogram. (pagepressjournals.org)
• Subsequent electrocardiogram (ECG) revealed premature ventricular couplets with ST-segment elevation in V^sub 1^ and V^sub 2^ of the precordial leads with T-wave abnormalities. (redorbit.com)
• This case describes a 40-year-old active duty senior pilot who, while undergoing his annual flight physical examination, demonstrated a premature ventricular couplet (PVC) on screening electrocardiogram (ECG). (redorbit.com)
• Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation. (cdc.gov)
• An electrocardiogram (ECG) test can help detect Brugada pattern in such people. (medindia.net)
• We report the first case of lidocaine-induced Brugada electrocardiogram phenotype. (ahajournals.org)
• The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. (medsci.org)

Left ventricular noncompaction1

• Congenital forms include hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction cardiomyopathy, coronary anomaly, and repaired or unrepaired congenital heart disease. (cmaj.ca)

Outflow5

• Recently, epicardial mapping has revealed abnormal electrograms at the right ventricular (RV) outflow tract and inferior region of the right ventricle. (ahajournals.org)
• Monomorphic VA is classified on the basis of site of origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricular fascicles. (onlinejacc.org)
• Case of Ebstein anomaly complicated by left ventricular outflow tract obstruction secondary to deformed basal septum attributable to atrialized right ventricle. (thefreedictionary.com)
• Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. (thefreedictionary.com)
• Although, this patient exhibited eccentric left ventricular hypertrophy, such alteration is recognized as an uncommon finding in subjects diagnosed with aortic stenosis, which usually causes concentric hypertrophy secondary to the increased resistance imposed by the ventricular outflow tract obstruction. (thefreedictionary.com)

SCN5A1

• We have screened SCN5A in a large 8-generation kindred characterized by a high incidence of nocturnal sudden death, and QT-interval prolongation and the "Brugada ECG" occurring in the same subjects. (ahajournals.org)

19922

• It is named after the Catalan cardiologists Pedro and Josep Brugada who described the condition in 1992. (wikipedia.org)
• 1 In 1992, Brugada and Brugada 2 described 8 patients with unique ECG findings consisting of right bundle-branch block and ST-segment elevation in leads V 1 through V 3 , normal Q-T interval, and aborted cardiac death. (ahajournals.org)

Tachyarrhythmias6

• LQTS is a familial disease 1 2 characterized by abnormally prolonged ventricular repolarization and high risk of malignant ventricular tachyarrhythmias, often but not always occurring in the setting of high adrenergic activity, ie, physical or emotional stress. (ahajournals.org)
• 11 Acute myocardial ischemia leads to contraction band necrosis, infarction, and ultimately scar formation that forms an electrically unstable substrate for ventricular tachyarrhythmias. (acc.org)
• The interval from the peak to the end of the electrocardiographic (ECG) T wave (Tp-Te) can estimate cardiovascular mortality and ventricular tachyarrhythmias. (dovepress.com)
• 6 , 7 Furthermore, an increased Tp-Te interval could be a practical index to estimate cardiovascular mortality and ventricular tachyarrhythmias. (dovepress.com)
• Some patients are aware of virtually every premature ventricular beat, but others are unaware of even complex atrial or ventricular tachyarrhythmias. (merckmanuals.com)
• Ventricular fibrillation is more common in the setting of tachyarrhythmias (VT), bradycardia or asystole may happen if the conduction system is blocked by the heart attack, and EMD/PEA may be the result if the heart suffers severe damage. (medhelp.org)

Hypertrophic cardiomyopathy1

• Hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy (ARVC) both can cause deadly arrhythmias. (ottawaheart.ca)

Ablation7

• As a consequence, catheter ablation of sustained monomorphic VT is an important option to control recurrent ventricular tachycardias (VTs) but must be considered adjunctive to ICD placement, especially when structural heart disease is present. (clinicaladvisor.com)
• Of note is that Nademanee and colleagues ( Circulation 2011;123:1270-9) reported that epicardial catheter ablation at the anterior RVOT normalized the electrocardiographic abnormalities of BrS and prevented episodes of ventricular fibrillation. (acc.org)
• As the consequences, the importance of inhomogeneity of the cells in the sinus node, the validity of the ablation surgery for chronic atrial fibrillation and so on were indicated. (nii.ac.jp)
• This analysis shows that the benefits of dabigatran over a vitamin K antagonist in patients undergoing atrial fibrillation ablation are consistent across all geographic regions studied. (springermedizin.de)
• 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. (springermedizin.de)
• Dabigatran versus warfarin anticoagulation before and after catheter ablation for the treatment of atrial fibrillation. (healthtap.com)
• Dr. Huang is the Director of the electrophysiology section, and he specializes in treatment of patients with ventricular arrhythmias, especially ablation for ventricular tachycardia. (rochester.edu)

Cardiomyopathy3

• Ventricular fibrillation is also seen in those with cardiomyopathy, myocarditis, and other heart pathologies. (wikipedia.org)
• Very frequent ventricular ectopy may also result in a cardiomyopathy in a minority of patients. (onlinejacc.org)
• Cardiovascular magnetic resonance imaging may be appropriate if echocardiography does not provide an accurate assessment of ventricular function, e.g., in arrhythmogenic right ventricular cardiomyopathy/dysplasia or sarcoidosis ( 1-5 ). (onlinejacc.org)

Phenotype2

• Placement of the right precordial leads (V1 and V2) in a superior position (up to the second intercostal space) can increase the sensitivity of the ECG for detecting the Brugada phenotype in some patients,both in the presence or absence of a sodium block drug challenge. (clinicaladvisor.com)
• 3,4 Sodium channel blockers with slow dissociation kinetics such as flecainide and ajmaline are known to unmask the BrS ECG phenotype as well as precipitating ventricular tachycardia/fibrillation. (ahajournals.org)

Clinical5

• If a type 1 ECG is observed in the absence of any clinical criteria, this should be referred to as "idiopathic Brugada ECG pattern" and not as BS4. (escardio.org)
• 2013) has shown that in healthy individuals glucose by itself can prolong (with C-peptide antagonising the effects) the QT interval, which has long been used as a clinical index of the duration of ventricular repolarisation. (clinicaltrials.gov)
• The clinical presentation of proband was ventricular fibrillation. (go.jp)
• This article reviews the pharmacology, adverse effects and clinical evidence available to date on the use of dronedarone in the management of atrial fibrillation. (smw.ch)
• P-wave measurements are frequently used in clinical practice to predict atrial arrhythmias, especially atrial fibrillation (AF). (medsci.org)

Patients with atrial fibrillation2

• AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. (springermedizin.de)
• Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been recently approved by Swissmedic for management of patients with atrial fibrillation or atrial flutter. (smw.ch)

Genetic1

• Their brother Ramon Brugada was the first to describe one potential genetic cause in 1998. (wikipedia.org)

Episodes1

• When coming to our emergency unit after intubation he had another two episodes of ventricular fibrillation and blood analysis reveals a potassium of 2,6mmol/l. (endotext.org)

Conduction1

• Beware lead placement in the diagnosis of right ventricular conduction delay (rSr") and in the finding of Brugada pattern ECG. (blogspot.com)

Abnormal3

• Ventricular fibrillation (VFib) is a medical condition in which the heart beats in an abnormal rhythm. (differencebetween.net)
• This abnormal heart rhythm is known as ventricular fibrillation. (self.com)
• Hypokalemia and Ventricular Fibrillation- An ambulance EKG noted abnormal repolarisation with EKG presenting in a sinus rhythm with T wav. (medhelp.org)

Electrocardiographic3

• The Brugada electrocardiographic pattern is characterized by right bundle branch block morphology and ST segment elevations in the right precordial leads with an absence of identifiable underlying structural heart disease. (hindawi.com)
• We present the case of a 35-year-old male who presented with intestinal Shigellosis and was also found to have Brugada-type electrocardiographic changes on ECG. (hindawi.com)
• 3. Brugada J, Brugada R, Antzelevitch C, Towbin JA, Nademanee K, Brugada P:Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. (cogprints.org)

Elevation4

• This study was significant for STsegment elevation in V^sub 1^ and V^sub 2^ (Fig. 3), and the patient was referred to Dr. R. Brugada for further evaluation. (redorbit.com)
• Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3 : a marker for sudden death in patients without demonstrable structural heart disease. (springer.com)
• It is also important to be aware that some drugs (listed in table 3) may also produce a Brugada-like ST-segment elevation. (escardio.org)
• It is diagnosed by signature EKG changes including at least 2-mm J-point elevation with coved-type ST elevation and T-wave inversion in at least one right precordial leads (type I Brugada marker). (springer.com)

Atrial and ventricular2

• The regular cycle of atrial and ventricular contractions results in blood being pumped effectively out of the heart. (exclusivepapers.com)
• It can be both pro- and/or anti-arrhythmic at both the atrial and ventricular level of the myocardium. (bvsalud.org)

Paroxysmal Atrial Fibri3

• More data are available for the arrhythmogenic effects of the SNS, which, when overactive, can trigger atrial and/or ventricular "adrenergic" arrhythmias in susceptible individuals (e.g. in patients with paroxysmal atrial fibrillation-PAF, ventricular pre-excitation, specific channelopathies, ischemic heart disease or cardiomyopathies), while it can also negate the protective anti-arrhythmic drug effects. (bvsalud.org)
• Pilsicainide (four patients) or flecainide (one patient) were administered orally for the treatment of symptomatic paroxysmal atrial fibrillation or premature atrial contractions. (bmj.com)
• 1. Case Report A 45-year-old man had visited his local hospital because of paroxysmal atrial fibrillation that had started 9 years earlier. (deepdyve.com)

Abnormalities1

• Structural abnormalities in the heart such as right ventricular dilation, fibrous and fatty replacement of tissues of the right ventricle, and fibrotic disruption of the right bundle branch. (medindia.net)

Tachycardias1

• What are the supra ventricular tachycardias? (brainscape.com)

Structural2

• Monomorphic ventricular tachycardia (VT) in the presence of structural heart disease is largely attributed to anatomically bound macro-re-entry involving regions of myocardial scarring or the bundle branches. (onlinejacc.org)
• The overwhelming majority of VAs in patients without structural heart disease carry an excellent prognosis, and include premature ventricular complexes (PVCs), nonsustained VT, repetitive monomorphic VT, and sustained monomorphic VT. (onlinejacc.org)

Asymptomatic2

• In another asymptomatic-patient group in whom an ECG that discloses the Brugada sign is performed for routine reasons such as a workup prior to surgery or sport license or screening for insurance, risk stratification to find the patients at high risk is needed because in most cases these patients have a benign prognosis3,22,23. (cogprints.org)
• 4, recommended that all asymptomatic patients with the Brugada sign should undergo an EP study for risk stratification, and, if inducible, an ICD should be implanted since Brugada et al.3, reported that an overall 8% life-threatening event rate was found in initially asymptomatic patients. (cogprints.org)

LQTS1

• LQTS (ventricular myocardial repolarization). (differencebetween.net)

Structurally normal heart1

• Ventricular tachycardia (VT) rarely occurs in a structurally normal heart. (clinicaladvisor.com)

Premature Contractions2

• The Pharmacokinetics of Flecainide Acetate in Patients with Ventricular Premature Contractions. (nii.ac.jp)
• The Pharmacokinetics of Pirmenol and Its Suppressive Effects on Ventricular Premature Contractions. (nii.ac.jp)

Implantable cardioverter2

• Recent studies have confirmed a significant risk reduction in symptomatic patients with type 1 Brugada to as low as 0.8% to 3% with an implantable cardioverter defibrillator. (redorbit.com)
• Conclusion: Symptomatic patients displaying type 1 Brugada ECG (spontaneous or after sodium channel blockade) should receive an implantable cardioverter defibrillator and must be permanently disqualified. (redorbit.com)

Defibrillation1

• An automated external defibrillator detected ventricular fibrillation (VF), and a defibrillation shock was delivered by ambulance attendants. (deepdyve.com)

Life-threatening ventricular1

• Mendelian (i.e., monogenic) syndromes predisposing to life-threatening ventricular arrhythmias in young adults and children are genetically heterogeneous, with more than 25 genes identified so far (Table 1 ). (jci.org)