OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentHealth Care
Brucella VaccineBrucellaBrucellosisBrucella abortusBrucella melitensisVaccinesVaccines, InactivatedViral VaccinesBrucella ovisBacterial VaccinesVaccines, DNAVaccines, SyntheticVaccines, CombinedBrucella canisAIDS VaccinesBrucellosis, BovineVaccines, SubunitVaccines, ConjugateVaccinationMalaria VaccinesPapillomavirus Vaccines
Brucella Vaccine
A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.
Brucella
A genus of gram-negative, aerobic bacteria that causes BRUCELLOSIS. Its cells are nonmotile coccobacilli and are animal parasites and pathogens. The bacterium is transmissible to humans through contact with infected dairy products or tissue.
Brucellosis
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Brucella abortus
A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. Abortion and placentitis are frequently produced in the pregnant animal. Other mammals, including humans, may be infected.
Brucella melitensis
A species of the genus BRUCELLA whose natural hosts are sheep and goats. Other mammals, including humans, may be infected. In general, these organisms tend to be more virulent for laboratory animals than BRUCELLA ABORTUS and may cause fatal infections.
Vaccines
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Vaccines, Inactivated
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
Viral Vaccines
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Brucella ovis
A species of the genus BRUCELLA which are pathogenic to SHEEP.
Bacterial Vaccines
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Vaccines, DNA
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Vaccines, Synthetic
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Vaccines, Combined
Two or more vaccines in a single dosage form.
Brucella canis
A species of gram-negative bacteria infecting DOGS, the natural hosts, and causing canine BRUCELLOSIS. It can also cause a mild infection in humans.
AIDS Vaccines
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
Brucellosis, Bovine
A disease of cattle caused by bacteria of the genus BRUCELLA leading to abortion in late pregnancy. BRUCELLA ABORTUS is the primary infective agent.
Vaccines, Subunit
Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.
Vaccines, Conjugate
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
Vaccination
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Malaria Vaccines
Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.
Papillomavirus Vaccines
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.

Immunity to Brucella in mice vaccinated with a fraction (F8) or a killed vaccine (H38) with or without adjuvant. Level and duration of immunity in relation to dose of vaccine, recall injection and age of mice. (1/138)

Immunity to Brucella in the mouse, assessed by bacterial spleen counts 15 days after intraperitoneal inoculation of a standard challenge of B. abortus 544, has been studied with two vaccines, one experimental, composed of a fraction of the bacterial cell-wall (F8) extracted from B. abortus 99, the other of killed whole bacteria, B. melitensis 53 H38, taken as reference (H38). The level of primary immunity depended on the dose of vaccine, the presence of oil adjuvant and the age of the mouse. The presence of adjuvant enabled the immunization to F8 to continue beyond the first month, to reach its maximum around the fourth month, and to remain stable for at least 7 months. A booster injection 3 or 6 months after the primary vaccination reinforced existing immunity but did not increase it beyond a certain level. The effect of the recall injection was clearly demonstrated with low doses which gave a lower level of primary immunity.  (+info)

Antibody response to antigens distinct from smooth lipopolysaccharide complex in Brucella infection. (2/138)

The smooth lipopolysaccharide complex of the outer surface of smooth Brucella abortus cells is believed to be the antigenic component involved in serological tests routinely used for the diagnosis of brucellosis. Sera from cattle vaccinated or infected with B. abortus generally contain antibody directed toward the smooth lipopolysaccharide complex. The brucella organism contains a large number of other antigenically distinct components. The biological significance of some of these antigens has been demonstrated by showing that sera from infected cattle have precipitins to these components. These sera revealed up to seven distinct lines in immunoelectrophoresis with a protein-rich antigen mixture prepared from rough strain B. abortus 45/20, whereas sera from strain 19-vaccinated cattle did not reveal these lines at 4 or more months after vaccination. Monospecific antisera were prepared against six antigens in this mixture, and the purification of two of them by antibody affinity chromatography is described.  (+info)

Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK). (3/138)

Human brucellosis can be acquired from infected animal tissues by ingestion, inhalation, or contamination of the conjunctiva or traumatized skin by infected animal products. A vaccine to protect humans from occupational exposure or from zoonotic infection in areas where the disease is endemic would reduce an important cause of morbidity worldwide. Vaccines currently used in animals are unsuitable for human use. We tested a live, attenuated, purine-auxotrophic mutant strain of Brucella melitensis, WR201, for its ability to elicit cellular and humoral immune responses and to protect mice against intranasal challenge with B. melitensis 16M. Mice inoculated intraperitoneally with WR201 made serum antibody to lipopolysaccharide and non-O-polysaccharide antigens. Splenocytes from immunized animals released interleukin-2 (IL-2), gamma interferon, and IL-10 when cultured with Brucella antigens. Immunization led to protection from disseminated infection but had only a slight effect on clearance of the challenge inoculum from the lungs. These studies suggest that WR201 should be further investigated as a vaccine to prevent human brucellosis.  (+info)

Complement fixation test to assess humoral immunity in cattle and sheep vaccinated with Brucella abortus RB51. (4/138)

The live attenuated Brucella abortus strain RB51 is a rifampin-resistant, lipopolysaccharide (LPS) O-chain-deficient mutant of virulent B. abortus 2308. The reduced O-chain content in RB51 prevents this bacterium from inducing antibodies detectable by the conventional serologic tests for bovine brucellosis diagnosis that mainly identify antibodies to LPS. The absence of available serologic tests for RB51 also complicates the diagnosis of possible RB51 infections in humans exposed to this strain. The purpose of this study was to evaluate the suitability of a complement fixation (CF) test performed with the rough strain B. abortus RB51, previously deprived of anticomplementary activity, in detecting anti-B. abortus RB51 antibodies in cattle and sheep experimentally vaccinated with this strain. The results of this study showed that a CF test with RB51 as the antigen is able to specifically detect antibodies following RB51 vaccination in cattle and sheep. In addition, this method could be a useful tool for detecting B. abortus RB51 infection in humans.  (+info)

Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51. (5/138)

Brucella abortus strain RB51 is an attenuated rough strain that is currently being used as the official live vaccine for bovine brucellosis in the United States and several other countries. We reasoned that overexpression of a protective antigen(s) of B. abortus in strain RB51 should enhance its vaccine efficacy. To test this hypothesis, we overexpressed Cu/Zn superoxide dismutase (SOD) protein of B. abortus in strain RB51. This was accomplished by transforming strain RB51 with a broad-host-range plasmid, pBBR1MCS, containing the sodC gene along with its promoter. Strain RB51 overexpressing SOD (RB51SOD) was tested in BALB/c mice for its ability to protect against challenge infection with virulent strain 2308. Mice vaccinated with RB51SOD, but not RB51, developed antibodies and cell-mediated immune responses to Cu/Zn SOD. Strain RB51SOD vaccinated mice developed significantly (P < 0.05) more resistance to challenge than those vaccinated with strain RB51 alone. The presence of the plasmid alone in strain RB51 did not alter its vaccine efficacy. Also, overexpression of SOD did not alter the attenuation characteristic of strain RB51.  (+info)

Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses. (6/138)

Brucella abortus strain RB51 is a stable, rough, attenuated mutant widely used as a live vaccine for bovine brucellosis. Our ultimate goal is to develop strain RB51 as a preferential vector for the delivery of protective antigens of other intracellular pathogens to which the induction of a strong Th1 type of immune response is needed for effective protection. As a first step in that direction, we studied the expression of a foreign reporter protein, beta-galactosidase of Escherichia coli, and the 65-kDa heat shock protein (HSP65) of Mycobacterium bovis in strain RB51. We cloned the promoter sequences of Brucella sodC and groE genes in pBBR1MCS to generate plasmids pBBSODpro and pBBgroE, respectively. The genes for beta-galactosidase (lacZ) and HSP65 were cloned in these plasmids and used to transform strain RB51. An enzyme assay in the recombinant RB51 strains indicated that the level of beta-galactosidase expression is higher under the groE promoter than under the sodC promoter. In strain RB51 containing pBBgroE/lacZ, but not pBBSODpro/lacZ, increased levels of beta-galactosidase expression were observed after subjecting the bacteria to heat shock or following internalization into macrophage-like J774A.1 cells. Mice vaccinated with either of the beta-galactosidase-expressing recombinant RB51 strains developed specific antibodies of predominantly the immunoglobulin G2a (IgG2a) isotype, and in vitro stimulation of their splenocytes with beta-galactosidase induced the secretion of gamma interferon (IFN-gamma), but not interleukin-4 (IL-4). A Th1 type of immune response to HSP65, as indicated by the presence of specific serum IgG2a, but not IgG1, antibodies, and IFN-gamma, but not IL-4, secretion by the specific-antigen-stimulated splenocytes, was also detected in mice vaccinated with strain RB51 containing pBBgroE/hsp65. Studies with mice indicated that expression of beta-galactosidase or HSP65 did not alter either the attenuation characteristics of strain RB51 or its vaccine efficacy against B. abortus 2308 challenge.  (+info)

Structural, functional and immunological studies on a polymeric bacterial protein. (7/138)

The characterization of proteins from Brucella spp, the causative agent of brucellosis, has been the subject of intensive research. We have described an 18-kDa cytoplasmic protein of Brucella abortus and shown the potential usefulness of this protein as an antigen for the serologic diagnosis of brucellosis. The amino acid sequence of the protein showed a low but significant homology with that of lumazine synthases. Lumazine is an intermediate product in bacterial riboflavin biosynthesis. The recombinant form of the 18-kDa protein (expressed in E. coli) folds like the native Brucella protein and has lumazine-synthase enzymatic activity. Three-dimensional analysis by X-ray crystallography of the homolog Bacillus subtilis lumazine synthase has revealed that the enzyme forms an icosahedral capsid. Recombinant lumazine synthase from B. abortus was crystallized, diffracted X rays to 2.7-A resolution at room temperature, and the structure successfully solved by molecular replacement procedures. The macromolecular assembly of the enzyme differs from that of the enzyme from B. subtilis. The Brucella enzyme remains pentameric (90 kDa) in its crystallographic form. Nonetheless, the active sites of the two enzymes are virtually identical at the structural level, indicating that inhibitors of these enzymes could be viable pharmaceuticals across a broad species range. We describe the structural reasons for the differences in their quaternary arrangement and also discuss the potential use of this protein as a target for the development of acellular vaccines.  (+info)

Validation of the abbreviated Brucella AMOS PCR as a rapid screening method for differentiation of Brucella abortus field strain isolates and the vaccine strains, 19 and RB51. (8/138)

The Brucella AMOS PCR assay was previously developed to identify and differentiate specific Brucella species. In this study, an abbreviated Brucella AMOS PCR test was evaluated to determine its accuracy in differentiating Brucella abortus into three categories: field strains, vaccine strain 19 (S19), and vaccine strain RB51/parent strain 2308 (S2308). Two hundred thirty-one isolates were identified and tested by the conventional biochemical tests and Brucella AMOS PCR. This included 120 isolates identified as B. abortus S19, 9 identified as B. abortus strain RB51, 57 identified as B. abortus biovar 1, 15 identified as B. abortus bv. 2, 1 identified as B. abortus bv. 2 (M antigen dominant), 7 identified as B. abortus bv. 4, and 22 identified as B. abortus S2308 and isolated from experimentally infected cattle. The Brucella AMOS PCR correctly identified each isolate as RB51/S2308, S19, or a field strain of Brucella.  (+info)

Expression and Localization of Green Fluorescent Protein in B. abortus strain RB51 - OpenThesis
Brucella abortus is a facultative intracellular bacterial pathogen, which causes abortion in cattle and undulant fever in human. B. abortus strain RB51 (Strain RB51) is the official vaccine for bovine brucellosis in the USA. B. abortus strain RB51 can be used as a vector for the over-expression of its own (homologous) as well as heterologous protective antigens. The immune system can detect these heterologous antigens and produce a response. Expressing a protein in different bacterial compartments has been shown to affect its accessibility to the immune system and the way the antigen is processed by antigen presenting cells. In order to determine if the immune response is affected by the localization of the antigen, green fluorescent protein (GFP) was expressed at three different locations in B. abortus strain RB51, outer-membrane (OM), periplasmic space (PS) and in the cytoplasmic region (CR) of B. abortus strain RB51. This localization was obtained by transforming strain RB51 with plasmids ...
http://www.openthesis.org/documents/Expression-Localization-Green-Fluorescent-Protein-584906.html
Immunogens of Brucella Abortus S19 Identified By Two-Dimensional Gel Electrophoresis and ImmunoblottingImmunogens of Brucella Abortus S19 Identified By Two-Dimensional Gel Electrophoresis and Immunoblotting
Background: Lipopolysaccharides (LPSs) and several antigenic proteins of Brucella have been considered for preparation of diagnostic reagents and subunit vaccines. The objective of this study was to identify and compare immunogens of B. abortus S19 which induce humoral immune responses in human, goat and rabbit. Material and Methods: The bacterial whole cell extract was prepared in extraction buffer and resolved using two-dimensional gel electrophoresis (2-DE). The resolved antigens were reacted against human, goat and rabbit sera using western blotting. Results: At least 19, 14 and 16 immunogenic proteins were recognized in western blotting with human, goat and rabbit sera, respectively. The most abundant proteins of the bacterium with immunogenic properties in goat and rabbit but not in human, were a group of 5-6 proteins with molecular masses of 32-34 KDa and isoelectric point (pI) ranging from 4.5 to 5.7. In contrast, a group of 5 proteins with molecular weight of 45 KDa and pI in the range of 4.5
http://ijms.sums.ac.ir/index.php/IJMS/article/viewFile/1923/journal/journal/article_40068.html
Evaluation fo Live Attenuated B. Melitensis Vaccines in Nonhuman Primates - Thomas FichtEvaluation fo Live Attenuated B. Melitensis Vaccines in Nonhuman Primates - Thomas Ficht
The goal of our proposed research is to develop a Brucella vaccine that is safe for human use. Our approach has explored the use of live attenuated vaccines, si...
http://grantome.com/grant/NIH/U54-AI057156-09-6317
Fiber optics expansion connects North Shore to jobs - New Orleans CityBusinessFiber optics expansion connects North Shore to jobs - New Orleans CityBusiness
Telecommunications firms have increasingly turned to fiber optics technology, which uses glass or plastic fibers to transmit data more quickly than traditional
https://neworleanscitybusiness.com/blog/2014/07/30/fiber-optics-expansion-connects-north-shore-to-jobs/
Title page for ETD etd-05192003-110707Title page for ETD etd-05192003-110707
Brucella abortus is a facultative intracellular bacterial pathogen, which causes abortion in cattle and undulant fever in human. B. abortus strain RB51 (Strain RB51) is the official vaccine for bovine brucellosis in the USA. B. abortus strain RB51 can be used as a vector for the over-expression of its own (homologous) as well as heterologous protective antigens. The immune system can detect these heterologous antigens and produce a response. Expressing a protein in different bacterial compartments has been shown to affect its accessibility to the immune system and the way the antigen is processed by antigen presenting cells. In order to determine if the immune response is affected by the localization of the antigen, green fluorescent protein (GFP) was expressed at three different locations in B. abortus strain RB51, outer-membrane (OM), periplasmic space (PS) and in the cytoplasmic region (CR) of B. abortus strain RB51. This localization was obtained by transforming strain RB51 with plasmids ...
http://theses.lib.vt.edu/theses/available/etd-05192003-110707/
Draft Genome Sequences of Two Brucella abortus Strains Isolated from Cattle and Pig [Abstract]Draft Genome Sequences of Two Brucella abortus Strains Isolated from Cattle and Pig [Abstract]
Abstract. We report the draft genome sequences of two Brucella abortus strains LMN1 and LMN2 isolated from cattle and pig. The LMN1 and LMN2 have the genome size of 3,395,952 bp and 3,334,792 bp, respectively. In addition to the conserved genes of Brucella, few novel regions showing similarity to the phages were identified in both strains.. Keywords: genome sequence, Brucella abortus ...
http://jgenomics.com/v03p0095
Volume9,Issue3 - IJPCRVolume9,Issue3 - IJPCR
Brucellosis is a disease that can be prevented through vaccination. Yet, the effectiveness of the vaccination to fight this disease is considered weak. Fortunately, attempts to modify brucellosis vaccine is still keep going. Some brucellosis vaccines have been found and developed in the past time such as the vaccine B.abortus strain 19-BA and 104M which was made from weakened microbes which had been widely used in Uni Soviet and China. The other brucellosis vaccine that were used in the past were the phenolinsoluble peptidoglycan vaccine which was made in France and polysaccharide-protein vaccine which was used in Russia. This research attempted to see the determinant of antigenic Outer Membrane Protein (OM) 36 kDa Brucella abortus local isolation which has immunogenic character to be developed as an advanced brucellosis vaccine. The method used in this research was the Omp2 gene of Brucella abortus of local isolate employed the PCR technique. The result of the PCR was then sequenced to analyze ...
https://ijpcr.com/volume9issue3/
nanM - N-acetylneuraminate epimerase precursor - Brucella abortus (strain 2308) - nanM gene & proteinnanM - N-acetylneuraminate epimerase precursor - Brucella abortus (strain 2308) - nanM gene & protein
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
https://www.uniprot.org/uniprot/Q2YK69
KEGG PATHWAY: Ubiquinone and other terpenoid-quinone biosynthesis - Brucella abortus S19
Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria ...
http://www.genome.jp/kegg-bin/show_pathway?bmc00130
Overview of small animal brucellosis control strategies - EnglishOverview of small animal brucellosis control strategies - English
Presented by Steven Olsen at a workshop on an integrated approach to controlling brucellosis in Africa, Addis Ababa, Ethiopia, 29-31 January 2013.
https://www.slideshare.net/ILRI/brucellosis-olson4
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IMMUNOGENIC PROPERTIES OF SOLUBLE ANTIGENS OR WHOLE CELLS OF BRUCELLA ABORTUS STRAIN 45/20 ASSOCIATED WITH IMMUNOADJUVANTS. I: SOLUBLE ANTIGENSWOODARD LF; TOONE NM; MCLAUGHLIN CA et al.1980; CAN. J. COMP. MED.; ISSN 0008-4050; CAN; DA. 1980; VOL. 44; NO 4; PP. 453-455; ABS. FRE; BIBL. 9 REF.Article ...
https://pascal-francis.inist.fr/vibad/index.php?action=search&lang=en&terms=%22IMMUNOLOGICAL+ADJUVANT%22&index=kw
Immune mechanisms in murine brucellosis : studies with strain RB51, a rough mutant of Brucella abortusImmune mechanisms in murine brucellosis : studies with strain RB51, a rough mutant of Brucella abortus
The roles of humoral and cell mediated immune responses in murine brucellosis were investigated in this study.B. abortus strain 19, the current vaccine strain, is known to induce an antibody as well as cell mediated immune responses, both of which protect mice against smooth strain 2308. B. abortus rough strain RB51 does not induce an o-side chain specific antibody response and yet protects mice against smooth strain 2308. Passive transfer experiments using serum and nylon wool enriched T cells obtained from micevaccinated with strain 19 and strain RB51 were carried out. Immune senum from strain 19 vaccinated mice protected against challenge with strain 2308 but not strain RB51. Nylon wool enriched T cells from strain 19 vaccinated mice protected recipient mice against challenge with both strains RB51 or 2308. Serum obtained from RB51 vaccinated mice did not protect recipient mice against challenge with either strain RB51 or strain 2308. Nylon wool enriched T cells from the same vaccinated mice, ...
https://vtechworks.lib.vt.edu/handle/10919/39363
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O-chain expression in the rough Brucella melitensis strain B115: induction of O-polysaccharide-specific monoclonal antibodies...O-chain expression in the rough Brucella melitensis strain B115: induction of O-polysaccharide-specific monoclonal antibodies...
Spleen cells from mice infected with the rough Brucella melitensis strain B115 were fused with NSO myeloma cells. Hybridoma supernatants were screened in ELISA with cell walls (CW), sonicated cell extracts (CE) and rough lipopolysaccharide (R-LPS) of B. melitensis strain B115 and whole B. melitensis B115 cells. Surprisingly, 22 monoclonal antibodies (mAbs) reacting in ELISA with both CW and CE but not with R-LPS and bacterial cells were shown by immunoblot analysis and ELISA to react with smooth lipopolysaccharide (S-LPS). These mAbs also reacted in ELISA with O polysaccharides (OPS) from the smooth Brucella abortus strain 99 and the smooth B. melitensis strain 16M and thus recognize epitopes present on the O-chain. Proteinase K LPS preparations from B. melitensis B115 analysed by immunoblotting with one mAb (12G12) recognizing S-LPS of both A and M specificity displayed the typical S-LPS high-molecular-mass ladder pattern but no S-LPS was detected in the phenol/water/chloroform/light petroleum LPS
https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-138-6-1211
Genome Sequence of Brucella abortus Vaccine Strain S19 Compared to Virulent Strains Yields Candidate Virulence GenesGenome Sequence of Brucella abortus Vaccine Strain S19 Compared to Virulent Strains Yields Candidate Virulence Genes
The Brucella abortus strain S19, a spontaneously attenuated strain, has been used as a vaccine strain in vaccination of cattle against brucellosis for six decades. Despite many studies, the physiological and molecular mechanisms causing the attenuation are not known. We have applied pyrosequencing technology together with conventional sequencing to rapidly and comprehensively determine the complete genome sequence of the attenuated Brucella abortus vaccine strain S19. The main goal of this study is to identify candidate virulence genes by systematic comparative analysis of the attenuated strain with the published genome sequences of two virulent and closely related strains of B. abortus, 9-941 and 2308. The two S19 chromosomes are 2,122,487 and 1,161,449 bp in length. A total of 3062 genes were identified and annotated. Pairwise and reciprocal genome comparisons resulted in a total of 263 genes that were non-identical between the S19 genome and any of the two virulent strains. Amongst these, 45 genes
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002193
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
Fingerprint Dive into the research topics of Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. Together they form a unique fingerprint. ...
https://researchportal.unamur.be/en/publications/replication-of-brucella-abortus-and-brucella-melitensis-in-fibrob/fingerprints/
Brucella suis vjbR polyclonal antibody - (PAB16064) - Products - Abnova
Rabbit polyclonal antibody raised against full length recombinant Brucella suis vjbR. Recombinant protein corresponding to full length Brucella suis vjbR. (PAB16064) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB16064
Attenuation and immunogenicity of a Brucella abortus htrA cycL double by Matthew Edmonds, Natha Booth et al.Attenuation and immunogenicity of a Brucella abortus htrA cycL double by Matthew Edmonds, Natha Booth et al.
PHE1 is a htrA cycL double gene deletion mutant of virulent Brucella abortus strain 2308 (S2308) which has previously been evaluated in the murine and caprine models of bovine brucellosis. This report describes the results of studies conducted with this mutant in the natural bovine host. Six sexually mature, non-gravid heifers were inoculated via the conjunctival sac with 1x1010 colony forming units (CFU) of either the parental S2308 or the htrA cycL gene deletion mutant, PHE1. At 4, 7 and 11 days post-inoculation, PHE1 was found to colonize the bovine host at lower levels than S2308. In a second experiment, eight heifers in mid-gestation were infected with 1x107CFU of either strain via the conjunctival sac. The virulent S2308 caused abortions or weak calves in 4/4 cows, while all four cows infected with PHE1 had healthy calves. Furthermore, PHE1 exhibited decreased resistance to killing by cultured bovine neutrophils and macrophages compared to the parental strain. These studies demonstrate that the B.
https://digitalcommons.lsu.edu/animalsciences_pubs/520/
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1...Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1...
Pathogens infecting mammalian cells have developed various strategies to suppress and evade their hosts defensive mechanisms. In this line, the intracellular bacteria that are able to survive and propagate within their host cells must have developed strategies to avert their hosts killing attitude. Studying the interface of host-pathogen confrontation can provide valuable information for defining therapeutic approaches. Brucellosis, caused by the Brucella strains, is a zoonotic bacterial disease that affects thousands of humansand animals around the world inflicting discomfort and huge economic losses. Similar to many other intracellular dwelling bacteria, infections caused by Brucella are difficult to treat, and hence any attempt at identifying new and common therapeutic targets would prove beneficial for the purpose of curing infections caused by the intracellular bacteria. In THP-1 macrophage infected with Brucella melitensis we studied the expression levels of four hosts genes, i.e. EMP2, ST8SIA4
http://ijvr.shirazu.ac.ir/article_3290.html
Frontiers | TLR7 and TLR3 Sense Brucella abortus RNA to Induce Proinflammatory Cytokine Production but They Are Dispensable for...Frontiers | TLR7 and TLR3 Sense Brucella abortus RNA to Induce Proinflammatory Cytokine Production but They Are Dispensable for...
Brucella abortus is a Gram-negative, facultative intracellular bacterium that causes brucellosis, a worldwide zoonotic disease leading to undulant fever in humans and abortion in cattle. The immune response against this bacterium relies on the recognition of microbial pathogen-associated molecular patterns, such as lipoproteins, lipopolysaccharides and DNA; however, the immunostimulatory potential of B. abortus RNA remains to be elucidated. Here, we show that dendritic cells (DCs) produce significant amounts of IL-12, IL-6 and IP-10/CXCL10, when stimulated with purified B. abortus RNA. IL-12 secretion by DCs stimulated with RNA depends on TLR7 while IL-6 depends on TLR7 and partially on TLR3. Further, only TLR7 plays a role in IL-12 production induced by B. abortus infection. Moreover, cytokine production in DCs infected with B. abortus or stimulated with bacterial RNA was reduced upon pretreatment with MAPK/NF-κB inhibitors. By confocal microscopy, we demonstrated that TLR7 is colocalized with B.
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00028/full
Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharideBrucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
La mayoría de las infecciones bacterianas inducen la activación de los neutrófilos polimorfonucleares (PMN), mejoran su función microbicida y promueven la supervivencia de estos leucocitos durante períodos prolongados. Brucella abortus es un patógeno sigiloso que evade la inmunidad innata, apenas activa los PMN y resiste los mecanismos de destrucción de estos fagocitos. Los intrigantes signos clínicos que se observan durante la brucelosis son el bajo número de PMN infectados por Brucella en los órganos diana y la neutropenia en una proporción de los pacientes; características que merecen una mayor atención. Aquí demostramos que B.abortus mata prematuramente a los PMN humanos de forma dosis dependiente y específica de la célula. La muerte de los PMNs es concomitante con la liberación de lipopolisacáridos intracelulares de Brucella (Br-LPS) en vacuolas. Esta molécula y su lípido A reproducen la muerte celular prematura de los PMN, un fenómeno asociado a la baja producción de ...
https://repositorio.una.ac.cr/handle/11056/17601
Relapsing brucella hepatitis due to Brucella abortus following doxycycline-streptomycin treatment [Medeniyet Med J]
We report a case of Brucella abortus-induced brucellosis that displayed high hepatic transaminases similar to that in acute hepatitis, fourth month relapsed following doxycycline-streptomycin treatment, and developed doxycycline-related hepatotoxicity in second treatment. Brucella hepatitis may occur with various Brucella spp. and may relapse even following ...
http://medeniyetmedicaljournal.org/jvi.aspx?pdir=medeniyet&plng=eng&un=MEDJ-85866
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
https://researchportal.unamur.be/en/publications/replication-of-brucella-abortus-and-brucella-melitensis-in-fibrob/equipments/
Brucella Series Symptom Relief: Series Kit - nupathways.com
Brucella Series Symptom Relief kit is for the temporary relief of symptoms related to Brucella infection including fever, sweats, malaise, headache, back pain, neck pain, malodorous sweat, peculiar taste in mouth and gut inflammation.. A kit contains ten vials, each with a -different safe and -effective dilution of the actual deactivated virus or bacteria the kit is intended to address. The vials are taken in series, first increasing in potency for the first 30 days of the protocol, then decreasing in potency for the second 30 days to provide a full 60 days of symptom relief.. The basic 60-Day Series Protocol requires two ten-vial kits. Each vial is taken all at once, with the contents held under the tongue for 30 seconds. The first kit is taken over a 30-day period, one vial every three days, in ascending order (from #1 to #10). The second kit is then taken over 30 days (one vial every three days) in descending order (from vial #10 to vial #1).. This ascending and descending sequence provides ...
https://nupathways.com/brucella-series-symptom-relief-series-kit/
Brucella BvrR protein Summary Report | CureHunterBrucella BvrR protein Summary Report | CureHunter
Brucella BvrR protein: BvrR/BvrS represent the two-component system involved in the regulation of Brucella virulence; amino acid sequence in first source
http://www.curehunter.com/public/keywordSummaryC471339-Brucella-BvrR-protein.do
FUN 05 | SSGCID
FUN_05: Use the SSGCID solved structure of Brucella melitensis methionine-tRNA-synthetase (MetRS) to find inhibitors for potential drug development for brucellosis.
https://www.ssgcid.org/target-status/functional/fun_05/
Survivor Tails Animal Recues 1st Annual Rescue Romp - 09/03/2021 - Race InformationSurvivor Tails Animal Recues 1st Annual Rescue Romp - 09/03/2021 - Race Information
Survivor Tails Animal Recues 1st Annual Rescue Romp information, race map, race results, race reviews, and race date. Learn why you should run Survivor Tails Animal Recues 1st Annual Rescue Romp in tremont street, MD.
https://www.raceentry.com/survivor-tails-animal-recues-1st-annual-rescue-romp/race-information
Abortus BangAbortus Bang
Die Abortus Bang Ringprobe (ABR Test) ist eine serologische Untersuchung, die zum Nachweis von Brucellen in Milch genutzt wird. Hierbei werden die Antikörper (IgM, IgG, IgA) mit einem Hämatoxylin gekoppelten Antigen sichtbar demacht. Es handelt…
https://deacademic.com/dic.nsf/dewiki/24423/Abortus_Bang
Frontiers | Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and...Frontiers | Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and...
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation of the active disease in humans and we have previously demonstrated that B. abortus infection inhibits osteoblast function. We aimed to evaluate the role of cortisol and DHEA on osteoblast during B. abortus infection. B. abortus infection induces apoptosis and inhibits osteoblast function. DHEA treatment reversed the effect of B. abortus infection on osteoblast by increasing their proliferation, inhibiting osteoblast apoptosis and reversing the inhibitory effect of B. abortus on osteoblast differentiation and function. In contrast, cortisol increased the effect of B. abortus infection. Cortisol regulates target genes by binding to the glucocorticoid receptor (GR). B. abortus infection inhibited GR-α expression. Cells responses to cortisol not only depend on GR expression but also on its
https://www.frontiersin.org/articles/10.3389/fimmu.2018.00088/full
Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with...Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with...
Brucella spp. are the etiological agents of brucellosis, a zoonotic infectious disease that causes abortion in animals and chronic debilitating illness in humans. Natural Brucella infections occur primarily through an incompletely defined mechanism of adhesion to and penetration of mucosal epithelium. In this study, we characterized changes in genome-wide transcript abundance of the most and the least invasive growth phases of B. melitensis cultures to HeLa cells, as a preliminary approach for identifying candidate pathogen genes involved in invasion of epithelial cells. B. melitensis at the late logarithmic phase of growth are more invasive to HeLa cells than mid-logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase (the most invasive culture) compared to the stationary growth phase (the least invasive culture). As expected, the majority of up-regulated genes in late-log phase cultures were
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-9-81
Presence of two independent chromosomes in the Brucella melitensis 16M genome. | Journal of BacteriologyPresence of two independent chromosomes in the Brucella melitensis 16M genome. | Journal of Bacteriology
Mapping the restriction fragments of the Brucella melitensis 16M genome with a new restriction endonuclease, PacI, which cut the DNA into only eight fragments, indicated that this species contains two unique and independent replicons of about 2,100 and 1,150 kb. Pulsed-field gel electrophoresis of intact DNA revealed two bands migrating the expected distances. These replicons were identified as two unique and independent chromosomes by the presence of rRNA operons and genes for heat shock proteins mapping to separate replicons. ...
https://jb.asm.org/content/175/3/701?ijkey=db0a2fcf5f6c6e57fa6bc3eb77fef5e1530790b5&keytype2=tf_ipsecsha
foodproof Brucella Detection Kitfoodproof Brucella Detection Kit
The foodproof Brucella Detection Kit detects the genus Brucella and additionally identifies the two most common food-associated disease species Brucella abortus and Brucella melitensis. The rod-shaped, Gram-negative, aerobic bacteria are found in cows, sheep and pigs. The bacteria can be transmitted to humans through raw milk or meat causing brucellosis, also called Malta Fever.
https://www.bc-diagnostics.com/products/kits/real-time-pcr/foodborne-pathogens/foodproof-brucella-detection-kit/
Dendogram of global Brucella abortus biovar 1 genotypes | Open-iDendogram of global Brucella abortus biovar 1 genotypes | Open-i
Dendogram of global Brucella abortus biovar 1 genotypes. Dendogram based on MLVA-16 genotyping showing the relationship of 49 B. abortus biovar 1 strains origin
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4222555_1746-6148-9-233-2&req=4
Heat-stress-modulated induction of NF-κB leads to brucellacidal pro-inflammatory defense against Brucella abortus infection in...Heat-stress-modulated induction of NF-κB leads to brucellacidal pro-inflammatory defense against Brucella abortus infection in...
Brucella causes a chronic and debilitating infection that leads to great economic losses and a public health burden. In this study, we demonstrated the brucellacidal effect of heat shock mediated by the induction of pro-inflammatory cytokines, reactive oxygen species (ROS) accumulation and apoptosis in murine macrophages and in mice. RAW264.7 cells were incubated at 43 °C, and BALB/c mice were subjected to whole body hyperthermia. The data showed a reduction in bacterial survival in the mice after daily heat exposure. This was accompanied by increased levels of cytokines TNF, IL-6, IL-1β and IFN-γ in the sera of the mice. Gene expression of NF-κB and inducible nitric oxide production were also induced in the mouse splenic cells. In parallel with the bacterial reduction in the mouse model, an increased bactericidal effect was observed in RAW264.7 cells after exposure to heat stress. In addition, the heat stress increased both the nuclear translocation of NF-κB and the expression of the heat shock
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-018-1185-9
Genetic Characterization of a Tn5-Disrupted Glycosyltransferase Gene Homolog in Brucella abortus and Its Effect on...Genetic Characterization of a Tn5-Disrupted Glycosyltransferase Gene Homolog in Brucella abortus and Its Effect on...
In this study, we isolated and characterized B. abortusRA1, a transposon-derived rough mutant of standard strain 2308. We further identified the gene disrupted by Tn5 in strain RA1 as wboA, which encodes a putative glycosyltransferase, an enzyme which appears to be essential for the biosynthesis of the O side chain in B. abortus. LPS analysis of strains RA1 and RB51 indicated that both strains lack the O side chain. However, the reason for the presence of the intermediate LPS band in strain RA1 that is lacking in strain RB51 is not known (Fig. 1). One possibility is that the mutation in strain RA1 results in exposure of a glycose that can be glycosylated by glycosyltransferases that are not able to attach specific sugars in the parent or in strain RB51. The result may be a side branch in the core, generating a new glycoform. Evidence for this is the relatively high amount of galactose present in RA1, whereas only a trace amount of this glycose is present in RB51. Unfortunately, the nature of the ...
https://iai.asm.org/content/67/8/3830
Brucella infection - including symptoms, treatment and prevention :: SA HealthBrucella infection - including symptoms, treatment and prevention :: SA Health
Brucella bacteria bacteria are found in cattle, pigs, goats, sheep, working dogs and domestic animals mainly overseas - risk to travellers
http://www.sahealth.sa.gov.au/wps/wcm/connect/Public+Content/SA+Health+Internet/Health+topics/Health+conditions+prevention+and+treatment/Infectious+diseases/Brucella+infection/
Immune mediators of pathology in neurobrucellosis: from blood to central nervous systemImmune mediators of pathology in neurobrucellosis: from blood to central nervous system
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. [Cerrar ...
https://repositorio.inta.gob.ar/xmlui/handle/20.500.12123/6331
Plague and Other Bacterial Zoonotic Diseases | Sherris Medical Microbiology, 6e | AccessMedicine | McGraw-Hill MedicalPlague and Other Bacterial Zoonotic Diseases | Sherris Medical Microbiology, 6e | AccessMedicine | McGraw-Hill Medical
Brucella species are small, coccobacillary, Gram-negative rods that morphologically resemble Haemophilus and Bordetella. They are nonmotile, non-acid-fast, and non-spore-forming. The cells have a typical Gram-negative structure, and the outer membrane contains proteins. The genus Brucella contains nine closely related variants that differ primarily in their preferred terrestrial or marine hosts. Taxonomists vacillate as to whether they should be called species or something else. The three most commonly infecting humans, B abortus (cattle), B melitensis (sheep, goats), and B suis (swine), will all be referred to here as Brucella abortus or simply Brucella ...
https://accessmedicine.mhmedical.com/content.aspx?bookid=1020§ionid=56968778
mediaTUM - Media and Publication ServermediaTUM - Media and Publication Server
Brucella spp. are zoonotic Gram-negative intracellular pathogens with the ability to survive and replicate in phagocytes. It has been shown that bacterial proteins expressed abundantly in this niche are stress-related proteins capable of triggering effective immune responses. BMEI1549 is a molecular chaperone designated DnaK that is expressed under stress conditions and helps to prevent formation of protein aggregates. In order to study the potential of DnaK as a prospective Brucella subunit vaccine, immunogenicity and protective efficacy of recombinant DnaK from Brucella melitensis was evaluated in BALB/c mice. The dnak gene was cloned, expressed in Escherichia coli, and the resulting recombinant protein used as subunit vaccine. DnaK-immunized mice showed a strong lymphocyte proliferative response to in vitro antigen stimulation. Although comparable levels of antigen-specific IgG2a and IgG1 were observed in immunized mice, high amounts of IFN-?, IL-12 and IL-6, no detectable level of IL-4 and ...
http://mediatum.ub.tum.de/1254179?id=1254179&change_language=en
Induction of the Unfolded Protein Response by Brucella abortus VceC - Renee TsolisInduction of the Unfolded Protein Response by Brucella abortus VceC - Renee Tsolis
The innate immune system detects the presence of microbes in tissue by pattern recognition of conserved microbial structures, known as pathogen-associated molec...
http://grantome.com/grant/NIH/R01-AI109799-01A1
Molecular targets for rapid identification of Brucella sppMolecular targets for rapid identification of Brucella spp
Although not all of the differentiating genes identified were transcribed under steady state conditions, a group of genes sufficient to discriminate unambiguously between B. suis, B. melitensis, and B. abortus was identified. We present an overview of these genomic differences and the use of these f …
https://pubmed.ncbi.nlm.nih.gov/16504063/
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En tres municipios de Córdoba (Andalucía, España) se identificaron once casos de brucelosis. Se realizó un estudio de casos y controles, seleccionando tres casos por cada control. Las personas que consumieron queso de cabra fresco sin higienizar elaborado en una granja situada en el territorio epidémico, presentaban un mayor riesgo de padecer brucelosis (OR=21,6, IC 95%=1,6-639,8). Se identificó Brucella melitensis serotipo 3 en muestras clínicas, y en tejido de cabras y muestras de leche de la granja del rebaño. Se adoptaron medidas preventivas y el brote fue contenido tras la retirada del mercado de todos los quesos sospechosos, la desinfección y limpieza adicional de la granja y la realización de actividades de promoción sanitaria.
http://www.eurosurveillance.org/content/10.2807/esm.08.07.00421-es
Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51
Bacillus anthracis is a facultative intracellular bacterial pathogen that can cause cutaneous, gastrointestinal or respiratory disease in many vertebrates, including humans. Commercially available anthrax vaccines for immunization of humans are of limited duration and do not protect against the respiratory form of the disease. Brucella abortus is a facultative intracellular bacterium that causes chronic infection in animals and humans. As with other intracellular pathogens, cell mediated immune responses (CMI) are crucial in affording protection against brucellosis. B. abortus strain RB51 has been shown to be useful in eliciting protective cell mediated immunity and humoral responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce protective antibodies, it was decided that the objective of this research was to test whether the gene encoding PA could be expressed in Brucella producing a bivalent vaccine to protect against ...
https://vtechworks.lib.vt.edu/handle/10919/10039
Penggunaan Imunostik sebagai Uji Serologi untuk Deteksi Brucella abortus pada Sapi (APPLICATION IMMUNOSTICK ASSAY FOR...Penggunaan Imunostik sebagai Uji Serologi untuk Deteksi Brucella abortus pada Sapi (APPLICATION IMMUNOSTICK ASSAY FOR...
Serological test is one of diagnostic method to detect pathogenicity brucella. Several methods are being improving such as Rose Bengal Test (RBT), Complement Fixation Test (CFT) dan Enzyme-linked Immunosorbent Assay (ELISA). Immunostick has an accuracy equivalent to ELISA and is easy to apply in the field so it is possible to be applied as a rapid test for brucellosis detection. The study aim was to know sensitivity and specificity of immunostick that were used to detecte antibody Brucella abortus using commercial antigens of B. abortus Strain 19 (S19) and B. abortus Strain 99 (S99). The test have compared with ELISA. The tests were conducted in two stages, namely (i) immunostick ability to detect antibodies in seropositive and seronegative serum, and (ii) the immunostick result were compared with ELISA result in serum grup that were be know and unknown status. A total of 250 serums were examined and result indicated that immunostick can be detect B. abortus antibodies in cattle serum with ...
https://ojs.unud.ac.id/index.php/jvet/article/view/30976
Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene...Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene...
Brucella melitensis bacteria cause persistent, intracellular infections in small ruminants as well as in humans, leading to significant morbidity and economic loss worldwide. The majority of experiments on the transcriptional responses of Brucella to conditions inside the host have been performed following invasion of cultured mammalian cells, and do not address gene expression patterns during long-term infection. Here, we examine the application of the previously developed coincidence cloning methodology to recover and characterize B. melitensis RNA from the supramammary lymph node of experimentally-infected goats. Using coincidence cloning, we successfully recovered Brucella RNA from supramammary lymph nodes of B. melitensis-infected goats at both short-term (4 weeks) and long-term (38 weeks) infection time points. Amplified nucleic acid levels were sufficient for analysis of Brucella gene expression patterns by RNA-sequencing, providing evidence of metabolic activity in both the short-term and the
https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-018-0111-x/figures/6
Brucella endocarditis caused by brucella melitensis
We present a rare case of brucella endocarditis, forming a vegetation on the mitral valve. The definitive diagnosis has been made with clinical suspicion, positive serology, the demonstration of the vegetation with the echocardiography and with the production from the multiple blood culture of brucella melitensis and from the excised valve. Our patient has been successfully treated with specific antibiotherapy and the surgery of replacement of mitral valve. Our aim in presenting the case is to remind the infective endocarditis which is due to this factor in the regions like our country which is endemic for ...
http://connection.ebscohost.com/c/case-studies/101634984/brucella-endocarditis-caused-by-brucella-melitensis
View source for Brucella - microbewiki
Curated}} {{Biorealm Genus}} [[Image:brucella_close_up.JPG,thumb,400px,right,Electron micrograph of B. abortus located inside cisternae of Vero cell. Within the perinuclear envelope, the cisternae containing B. abortus are discontinuously lined by ribosomes (arrows). From [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2114362 Detilleux et al.]]] ==Classification== ===Higher order taxa:=== Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae ===Species:=== Brucella abortus, Brucella canis, Brucella cetaceae, Brucella maris , Brucella melitensis, Brucella pinnipediae, Brucella sp. {, , height=10 bgcolor=#FFDF95 align=center , NCBI: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=234 Taxonomy] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=genomeprj&cmd=Search&dopt=DocSum&term=txid234%5BOrganism:exp%5D Genomes] ,} ==Description and Significance== Brucella sp. causes brucellosis, ...
https://microbewiki.kenyon.edu/index.php?title=Brucella&action=edit
Most recent papers with the keyword Brucella abortus | Read by QxMDMost recent papers with the keyword Brucella abortus | Read by QxMD
In this study, we explore the regulatory roles of pro-inflammatory cytokine tumor necrosis factor alpha (TNF) in the innate immunity of macrophages against B. abortus infection. We show that infection of macrophage with B. abortus induces marked expression and secretion of TNF which subsequently binds to TNF receptor 1 (TNFR-1) and activates a downstream signaling cascade of the innate immunity. Blocking of TNF signaling resulted in a notable increase of B. abortus survival which was associated with an increase of anti-inflammatory cytokine interleukin 10 (IL-10), a beneficial effector of Brucella survival, as well as remarkable decrease of reactive oxygen species (ROS) and nitric oxide (NO), antibrucella molecules ...
https://www.readbyqxmd.com/keyword/51307
The outer membranes of Brucella spp. are not barriers to hydrophobic permeants. | Journal of BacteriologyThe outer membranes of Brucella spp. are not barriers to hydrophobic permeants. | Journal of Bacteriology
The patterns of susceptibility to hydrophobic and hydrophilic drugs and the uptake of the fluorescent probe N-phenyl-naphthylamine in Brucella spp., Haemophilus influenzae, Escherichia coli, and deep rough Salmonella minnesota mutants were compared. The results show that the outer membranes of smooth and naturally rough Brucella spp. do not represent barriers to hydrophobic permeants and that this absence of a barrier relates at least in part to the properties of Brucella lipopolysaccharide. ...
https://jb.asm.org/content/175/16/5273?ijkey=2fe718ca4f39339f3eba3b65202b8fdc8eab41c2&keytype2=tf_ipsecsha
Disease Listing, Brucellosis, General Information | CDC Bacterial, Mycotic Diseases
What is brucellosis? Brucellosis is an infectious disease caused by the bacteria of the genus Brucella. These bacteria are primarily passed among animals, and they cause disease in many different vertebrates. Various Brucella species affect sheep, goats, cattle, deer, elk, pigs, dogs, and several other animals. Humans become infected by coming in contact with animals or animal products that are contaminated with these bacteria. In humans brucellosis can cause a range of symptoms that are similar to the flu and may include fever, sweats, headaches, back pains, and physical weakness. Severe infections of the central nervous systems or lining of the heart may occur. Brucellosis can also cause long-lasting or chronic symptoms that include recurrent fevers, joint pain, and fatigue.. Back to Top How common is brucellosis? Brucellosis is not very common in the United States, where100 to 200 cases occur each year. But brucellosis can be very common in countries where animal disease control programs have ...
https://webarchive.library.unt.edu/eot2008/20090115152351/http:/www.cdc.gov/ncidod/dbmd/diseaseinfo/brucellosis_g.htm
In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31...In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31...
Designing a potent recombinant vaccine, using the appropriate subunits with the greatest effect on stimulating the immune system, especially in the case of intracellular pathogens such as gram negative Brucella Melitensis bacteria, is of great importance. In this study, three repeats of 27 amino acids of the immunogenic epitope derived from OMP31 antigen (3E) from the Brucella melitensis, in a protective manner against Brucellosis have been used. To fortify the delivery system of recombinant antigens, IL-2 cytokine as a molecular adjuvant was fused to recombinant constructs. Recombinant proteins were evaluated for immunological studies in a mouse model (BALB/c). The results showed that all recombinant proteins could stimulate the immune system to produce Th1 cytokines and antibodies in compare to the negative control treatments. 3E-IL2 and then OMP31-IL2 proteins stimulated higher levels of IFN-γ and IL-2 compared to the other treatments (p | 0.05). Also, the results indicated that experimental
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-2074-7
ICD-10 Diagnosis Code A23.0 Brucellosis due to Brucella melitensisICD-10 Diagnosis Code A23.0 Brucellosis due to Brucella melitensis
Diagnosis Code A23.0 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
https://icdlist.com/icd-10/a230
Abortus | definition of abortus by Medical dictionaryAbortus | definition of abortus by Medical dictionary
Looking for online definition of abortus in the Medical Dictionary? abortus explanation free. What is abortus? Meaning of abortus medical term. What does abortus mean?
http://medical-dictionary.thefreedictionary.com/Abortus
ureC2 - Urease subunit alpha 2 - Brucella abortus biovar 1 (strain 9-941) - ureC2 gene & proteinureC2 - Urease subunit alpha 2 - Brucella abortus biovar 1 (strain 9-941) - ureC2 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
https://www.uniprot.org/uniprot/Q57CE8
KEGG GENOME: Brucella abortus 2308KEGG GENOME: Brucella abortus 2308
Pathway modules Carbohydrate metabolism Central carbohydrate metabolism M00002 Glycolysis, core module involving three-carbon compounds [PATH:bmf00010 bmf01200 bmf01230 bmf01100 ...
https://www.kegg.jp/kegg-bin/show_organism?menu_type=pathway_modules&org=bmf
PCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO | Open-iPCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO | Open-i
PCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO-Ag, wbkD, wbkF, wboA and wa**. Panel A. Lanes: 1, molecular size markers; 2, manAO-Ag from B. melitensis
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2698832_1471-2180-9-92-3&req=4
Question: How Long Does Brucellosis Last? - take5japan.com
Doctors usually confirm a diagnosis of brucellosis by testing blood or bone marrow for the brucella bacteria or by testing blood for antibodies to the bacteria. To help detect complications of brucellosis, your doctor may order additional tests, including: X-rays. X-rays can reveal changes in your bones and joints ...
https://take5japan.com/qa/question-how-long-does-brucellosis-last.html
Measurement of Brucella species antibodyMeasurement of Brucella species antibody
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear. Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body. The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may ...
https://www.allinahealth.org/CCS/doc/Thomson%20Consumer%20Lab%20Database/49/150222.htm
Brucella - Microbiology Questions and AnswersBrucella - Microbiology Questions and Answers
This is the microbiology questions and answers section on Brucella with explanation for various interview, competitive examination and entrance test. Solved examples with detailed answer description, explanation are given and it would be easy to understand.
https://www.indiabix.com/microbiology/brucella/
British teacher sentenced to 40 lashes,for naming teddy bear Muhammad.British teacher sentenced to 40 lashes,for naming teddy bear Muhammad.
A British primary school teacher arrested in Sudan faces up to 40 lashes for blasphemy after letting her class of 7-year-olds name a teddy bear Muhammad. Gillian Gibbons, a 54-year-old mother of two from Liverpool, was arrested at her lodgings at Khartoums Unity High School yesterday, accused of insulting the Prophet of Islam. http://tinyurl.com/352sal
http://www.websleuths.com/forums/showthread.php?56665-British-teacher-sentenced-to-40-lashes-for-naming-teddy-bear-Muhammad
Brucella inopinataBrucella inopinata
"Serological Diagnosis of Brucella Infections in Odontocetes". Clinical and Vaccine Immunology. 16 (6): 906-915. doi:10.1128/CVI ... LPSN "Brucella inopinata" at the Encyclopedia of Life Type strain of Brucella inopinata at BacDive - the Bacterial Diversity ... Brucella inopinata is a Gram-negative, nonmotile, non-spore-forming coccoid bacterium, first isolated from a breast implant ... "Taxonomy of Brucella." Open Veterinary Science Journal 4.1 (2010): 85-101. Fischer, Dominik; Lorenz, Nadja; Heuser, Wenke; ...
https://en.wikipedia.org/wiki/Brucella_inopinata
Brucella cetiBrucella ceti
"Serological diagnosis of Brucella infections in odontocetes". Clinical and Vaccine Immunology. 16 (6): 906-15. doi:10.1128/CVI. ... LPSN "Brucella ceti" at the Encyclopedia of Life NOAA informative brochure Type strain of Brucella ceti at BacDive - the ... Brucella ceti is a gram negative bacterial pathogen of the Brucellaceae family that causes brucellosis in cetaceans. Brucella ... and Brucella pinnipedialis sp. nov. for Brucella strains with cetaceans and seals as their preferred hosts". International ...
https://en.wikipedia.org/wiki/Brucella_ceti
Brucella abortusBrucella abortus
Dorneles, EM; Sriranganathan, N; Lage, AP (8 July 2015). "Recent advances in Brucella abortus vaccines". Veterinary Research. ... Brucella has twelve different kinds of species, one being Brucella abortus. Some of the other species are known as B. ... "Humans and Brucella Species". "Brucellosis: Brucella Abortus" (PDF). Kaden, R.; Ferrari, S.; Jinnerot, T.; Lindberg, M.; Wahab ... Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The ...
https://en.wikipedia.org/wiki/Brucella_abortus
Brucella canisBrucella canis
PCR assays have been proven beneficial when differentiating between Brucella strains and vaccine strains. Mantur BG, Amarnath ... Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella ... rather than phenol-water like smooth forms of Brucella are known to be. Colonies of Brucella can typically start to be seen ... Brucella canis can be found in both pets and wild animals and lasts the lifespan of the animal it has affected. B. canis has ...
https://en.wikipedia.org/wiki/Brucella_canis
List of laboratory biosecurity incidentsList of laboratory biosecurity incidents
ISBN 978-0-10-295322-0. "Canadian-made Ebola vaccine used after German lab accident". cbc.ca. 2009-03-20. Retrieved 2009-03-20 ... Pappas, Georgios (2022-11-14). "The Lanzhou Brucella Leak: The Largest Laboratory Accident in the History of Infectious ... Shim, Elizabeth (2020-12-04). "Brucellosis cases in China exceed 10,000 after vaccine factory accident". UPI. Retrieved 2022-11 ... Song, Langui; Gao, Jiangmei; Wu, Zhongdao (April 2021). "Laboratory-acquired infections with Brucella bacteria in China". ...
https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity_incidents
Alpha-D-phosphohexomutase superfamilyAlpha-D-phosphohexomutase superfamily
Pei J, Ficht TA (January 2004). "Brucella abortus rough mutants are cytopathic for macrophages in culture". Infection and ... mutant as a new live rough-phenotype vaccine". Infection and Immunity. 71 (11): 6264-9. doi:10.1128/iai.71.11.6264-6269.2003. ... Ugalde JE, Czibener C, Feldman MF, Ugalde RA (October 2000). "Identification and characterization of the Brucella abortus ... Ugalde JE, Comerci DJ, Leguizamón MS, Ugalde RA (November 2003). "Evaluation of Brucella abortus phosphoglucomutase (pgm) ...
https://en.wikipedia.org/wiki/Alpha-D-phosphohexomutase_superfamily
Rakesh BhatnagarRakesh Bhatnagar
He helped develop a genetically engineered vaccine against anthrax. He is an elected fellow of several major Indian science ... His research group has initiated research in other important infectious disease systems like Mycobacterium, Brucella; aiming to ... His team has also developed a DNA vaccine against Rabies. ... Recombinant Vaccine Development, and Programmed Cell Death in ...
https://en.wikipedia.org/wiki/Rakesh_Bhatnagar
VIOLIN vaccine databaseVIOLIN vaccine database
Vaxign has been tested in different pathogen models, including uropathogenic E. coli and Brucella spp. VIOLIN also maintains ... VIOLIN currently contains over 3,000 vaccines or vaccine candidates for over 190 pathogens. The vaccine information in the ... Different types of information is curated, including vaccine name, license status, antigens used, vaccine adjuvants, vaccine ... All vaccine information in the VIOLIN vaccine database is supported by quoted references. The data generated by a curator is ...
https://en.wikipedia.org/wiki/VIOLIN_vaccine_database
Brucellosis vaccineBrucellosis vaccine
Brucella+vaccine at the US National Library of Medicine Medical Subject Headings (MeSH) Marta A. Guerra; Barun K. De. " ... Brucellosis vaccine is a vaccine for cattle, sheep and goats used against brucellosis. It is an attenuated vaccine based on a ... Animal vaccines, All stub articles, Vaccine stubs). ... there is no vaccine available for humans. Ko J, Splitter GA ( ... Drugs that are a vaccine, All articles with unsourced statements, Articles with unsourced statements from March 2021, ...
https://en.wikipedia.org/wiki/Brucellosis_vaccine
BrucellosisBrucellosis
Currently, all cattle of ages 3-8 months must receive the Brucella abortus strain 19 vaccine. Australia is free of cattle ... Brucella species survive well in aerosols and resist drying. Brucella and all other remaining biological weapons in the U.S. ... Dairy herds in the U.S. are tested at least once a year to be certified brucellosis-free with the Brucella milk ring test. Cows ... An animal vaccine is available that uses modified live bacteria. The World Organisation for Animal Health Manual of Diagnostic ...
https://en.wikipedia.org/wiki/Brucellosis
Owais MohammadOwais Mohammad
"Escheriosomes entrapped DNA vaccine co-expressing Cu-Zn superoxide dismutase and IL-18 confers protection against Brucella ... Vaccine. 2012, 6;30(48):6851-8. doi: 10.1016/j.vaccine.2012.09.010. Ansari MA, Zubair S, Mahmood A, Gupta P, Khan AA, Gupta UD ... Vaccine. 2006, 13;24(7):948-56. doi: 10.1016/j.vaccine.2012.09.010. Chauhan A, Zubair S, Tufail S, Sherwani A, Sajid M, Raman ... Vaccine. 2011, 24;29(29-30):4720-7. doi: 10.1016/j.vaccine.2011.04.088. Mallick AI, Singha H, Chaudhuri P, Nadeem A, Khan SA, ...
https://en.wikipedia.org/wiki/Owais_Mohammad
Interleukin 15Interleukin 15
A Brucella DNA vaccine containing IL-15 gene enhanced the CD8+ T cell immune response in mice. IL-15 was needed for CD4+ T cell ... "An IL-15 adjuvant enhances the efficacy of a combined DNA vaccine against Brucella by increasing the CD8+ cytotoxic T cell ... doi:10.1016/j.vaccine.2009.12.076. PMID 20064480. Hock K, Laengle J, Kuznetsova I, Egorov A, Hegedus B, Dome B, Wekerle T, ... Preclinical results of NDV-modified tumor vaccine showed promise by controlling melanoma tumor growth in mice. A recombinant ...
https://en.wikipedia.org/wiki/Interleukin_15
TularemiaTularemia
Sub-unit vaccine candidates, such as killed-whole cell vaccines, are also under investigation, however research has not reached ... Cross reactivity with Brucella can confuse interpretation of the results, so diagnosis should not rely only on serology. ... approved vaccines against tularemia. However, vaccination research and development continues, with live attenuated vaccines ... 2000). Manual of standards for diagnostic tests and vaccines: lists A and B diseases of mammals, birds and bees. Paris, France ...
https://en.wikipedia.org/wiki/Tularemia
Iraqi biological weapons programIraqi biological weapons program
Some of these materials were used for Iraq's biological weapons research program, while others were used for vaccine ... These materials included anthrax, West Nile virus and botulism, as well as Brucella melitensis, and Clostridium perfringens. ... Approximately 150,000 US troops received the U.S. Food and Drug Administration-licensed anthrax vaccine (BioThrax), and 8,000 ... and new research activities involving Brucella and Crimean-Congo hemorrhagic fever virus. Despite diligent investigations since ...
https://en.wikipedia.org/wiki/Iraqi_biological_weapons_program
Charles PiletCharles Pilet
A new type of vaccine Charles Pilet and Marc Bonneau are creating a new type of vaccine from a strain of Brucella abortus made ... An improved vaccine control method The study of several mouse lines showed the sensitivity of some of these lines to Brucella ... This type of vaccine also confirmed the essentially cellular nature of brucella immunity and the passive role of antibodies. A ... which made it possible to propose a new method for controlling brucella vaccines, a method that has since been adopted ...
https://en.wikipedia.org/wiki/Charles_Pilet
List of vaccine topicsList of vaccine topics
Negrón, María E.; Kharod, Grishma A.; Bower, William A.; Walke, Henry (2019). "Notes from the Field: Human Brucella abortus ... vaccine Caries vaccine Gonorrhea vaccine Ehrlichiosis vaccine Helicobacter pylori vaccine Leprosy vaccine Lyme disease vaccine ... vaccine Tularemia vaccine Yersinia pestis vaccine Chagas disease vaccine Hookworm vaccine Leishmaniasis vaccine Malaria vaccine ... encephalitis virus vaccine for humans Enterovirus 71 vaccine Epstein-Barr vaccine H5N1 vaccine Hepatitis C vaccine HIV vaccine ...
https://en.wikipedia.org/wiki/List_of_vaccine_topics
Azoximer bromideAzoximer bromide
... displayed ability to enhance immune responses to the live brucellosis vaccine, Brucella abortus strain 82-PS ( ... Immunopotentiation of live brucellosis vaccine by adjuvants. Vaccine 2010;28 Suppl 5:F17-22. Toptygina A, Semikina E, Alioshkin ... All vaccines of the Grippol family have two common features: firstly, they contain a reduced dose of antigens, and secondly, ... Several Grippol vaccines have been developed and approved based on a single technological platform that implements the ...
https://en.wikipedia.org/wiki/Azoximer_bromide
Julius YoungnerJulius Youngner
Offit, Paul A. (2007-09-01). The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis. Yale ... antitumor processes of Brucella, and numerous contributions to cold adapted influenza virus. Youngner met and married his first ... The Salk vaccine is based upon formalin inactivated wild type virus. The key to effective inactivation depended upon a color ... Applying this method to a single kidney "could produce enough raw material for 6000 shots of polio vaccine." This advance in ...
https://en.wikipedia.org/wiki/Julius_Youngner
BrucellaBrucella
... at Texas A&M University and her team claim to be close to creating a human vaccine. It would primarily be used to immunize ... Brucella abortus, Brucella canis, Brucella neotomae, Brucella ovis, and Brucella suis are all synonyms of Brucella melitensis. ... Brucella abortus A13334, 3,401 ORFs Brucella canis ATCC 23365, 3,408 ORFs Brucella melitensis 16M, 3,279 ORFs Brucella microti ... 3,193 ORFs Brucella pinnipedialis B2/94, 3,505 ORFs Brucella suis 1330, 3,408 ORFs Genome data for these and other Brucella ...
https://en.wikipedia.org/wiki/Brucella
Brucella suisBrucella suis
The Brucella abortus (rough LPS Brucella) vaccine, developed for bovine brucellosis and licensed by the USDA Animal Plant ... Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis ... of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella ... Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic ...
https://en.wikipedia.org/wiki/Brucella_suis
ATC code J07ATC code J07
J07BX01 Smallpox vaccines J07BX02 Ebola vaccines J07BX03 COVID-19 vaccines J07BX04 Dengue virus vaccines J07CA01 Diphtheria- ... J07AC01 Anthrax antigen J07AD01 Brucella antigen J07AE01 Cholera, inactivated, whole cell J07AE02 Cholera, live attenuated ... ATC code J07 Vaccines is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of ... C Empty group Vaccines for veterinary use are in the ATCvet group QI. "ATC (Anatomical Therapeutic Chemical Classification ...
https://en.wikipedia.org/wiki/ATC_code_J07
List of MeSH codes (D20)List of MeSH codes (D20)
... anthrax vaccines MeSH D20.215.894.135.134 - brucella vaccine MeSH D20.215.894.135.225 - cholera vaccines MeSH D20.215.894.135. ... hepatitis a vaccines MeSH D20.215.894.899.955.400 - hepatitis b vaccines MeSH D20.215.894.899.970 - yellow fever vaccine MeSH ... measles vaccine MeSH D20.215.894.899.404.500 - measles-mumps-rubella vaccine MeSH D20.215.894.899.488 - mumps vaccine MeSH ... rubella vaccine MeSH D20.215.894.899.779.500 - measles-mumps-rubella vaccine MeSH D20.215.894.899.790 - saids vaccines MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D20)
List of infectious diseasesList of infectious diseases
... oral adenovirus type 4 and type 7 vaccine, in U.S. Military recruits". Vaccine. 31 (28): 2963-2971. doi:10.1016/j.vaccine. ... Human Brucella abortus RB51 Infections Caused by Consumption of Unpasteurized Domestic Dairy Products - United States, 2017- ... "MERS vaccine shows promise in clinical trial, say researchers". Archived from the original on 2020-05-03. "Developing a vaccine ... doi:10.1016/j.vaccine.2012.10.003. PMID 23072894. "Collaboration to develop the world's first prophylactic gonorrhoea vaccine ...
https://en.wikipedia.org/wiki/List_of_infectious_diseases
Biosafety levelBiosafety level
... several species of Brucella, chikungunya, yellow fever virus, West Nile virus, Yersinia pestis, and SARS-CoV-2. Biosafety level ... aerosol-transmitted within the laboratory and cause severe to fatal disease in humans for which there are no available vaccines ...
https://en.wikipedia.org/wiki/Biosafety_level
EpigeneticsEpigenetics
... and Brucella. In Alphaproteobacteria, methylation of adenine regulates the cell cycle and couples gene transcription to DNA ... the bacterium to randomly change its characteristics into six alternative states that could pave the way to improved vaccines. ...
https://en.wikipedia.org/wiki/Epigenetics
PPIBPPIB
Aside from these bacteria, PPIB has been identified in Brucella abortus, Mycobacterium tuberculosis, Bacillus subtilis and ... recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes which could be used as cancer vaccines, and in fact ... "Intracellularly Induced Cyclophilins Play an Important Role in Stress Adaptation and Virulence of Brucella abortus". Infection ...
https://en.wikipedia.org/wiki/PPIB
Notifiable diseases in the United KingdomNotifiable diseases in the United Kingdom
... wild or vaccine types) Rabies virus (classical rabies and rabies-related lyssaviruses) Rickettsia spp Rift Valley fever virus ... Bordetella pertussis Borrelia spp Brucella spp Burkholderia mallei Burkholderia pseudomallei Campylobacter spp Chikungunya ...
https://en.wikipedia.org/wiki/Notifiable_diseases_in_the_United_Kingdom
MyocarditisMyocarditis
... and pericarditis can be a rare side effect of some vaccines like the smallpox vaccine. The Covid-19 mRNA vaccines ... Brucella, Corynebacterium diphtheriae, Neisseria gonorrhoeae, Haemophilus influenzae, Actinomyces, Tropheryma whipplei, Vibrio ... "Coronavirus (COVID-19) vaccines side effects and safety". nhs.uk. Retrieved 30 October 2022. "Risk of Myocarditis Following ... The FDA and European Medicines Agency estimates the risk of myocarditis after the Covid-19 vaccine as 1 case per 100,000 of ...
https://en.wikipedia.org/wiki/Myocarditis
Joseph VinetzJoseph Vinetz
He also used systems immunology to study the serial kinetics of the antibody response against the complete brucella melitensis ... vivax vaccine candidates. He studies endemic malaria in the context of the Peruvian Amazon region of Iquitos and discussed the ... and transmission-blocking vaccine development, including, in collaboration with Stephen Mayfield at UCSD, the use of ... with a key focus on vaccine development. Vinetz found cases of severe leptospirosis in relation to environmental exposure and ...
https://en.wikipedia.org/wiki/Joseph_Vinetz
Biological warfareBiological warfare
Hassani M, Patel MC, Pirofski LA (April 2004). "Vaccines for the prevention of diseases caused by potential bioweapons". ... Agents considered for weaponization, or known to be weaponized, include bacteria such as Bacillus anthracis, Brucella spp., ... Would demonstrate how to render a vaccine ineffective; Would confer resistance to therapeutically useful antibiotics or ... non-availability of vaccines and availability of an effective and efficient delivery system. Stability of the weaponized agent ...
https://en.wikipedia.org/wiki/Biological_warfare
BiopreparatBiopreparat
Brucella sp. (the causative agent of Brucellosis) Smallpox virus Venezuelan equine encephalitis virus Marburg virus Machupo ... operating in 15 different cities and had control of domestic production of vaccines, antibiotics and other essential medicines ...
https://en.wikipedia.org/wiki/Biopreparat
Campylobacter fetusCampylobacter fetus
The ovine Cff vaccine has likewise been found ineffective in preventing future infections in ewes given that it does not ... of the deceased fetus causes necrosis of the placenta and placental lesions are not easily distinguished from Brucella abortus ... As vaccines are typically not efficient in preventing future spread, infected bulls are often culled. Human infections may be ... Vaccines can be used to reduce the occurrence of campylobacteriosis but will not eradicate infections. For example, vaccination ...
https://en.wikipedia.org/wiki/Campylobacter_fetus
Emerging infectious diseaseEmerging infectious disease
"A brief history of vaccines and how they changed the world". World Economic Forum. Retrieved 2020-04-30. "Creating a world in ... Brucella species (brucellosis) Burkholderia pseudomallei (melioidosis) Burkholderia mallei (glanders) Coxiella burnetii (Q ... The proposed interventions were based on the following: the U.S. public health system, research and training, vaccine and drug ... such as vaccine-derived poliovirus The 1992 IOM report distinguished 6 factors contributing to emergence of new diseases ( ...
https://en.wikipedia.org/wiki/Emerging_infectious_disease
Karl Friedrich MeyerKarl Friedrich Meyer
Subsequently, a vaccine for horses was developed. And it turned out that the isolation of the virus by Meyer led to the ... He suggested classing the various species of bacteria into one family (genus), formally named Brucella, to honor the discoverer ... During the years of World War II a vaccine against yellow fever was used in the Armed Forces that produced (unexpectedly) ... It was actually manufactured at the Hooper when the Army needed vaccines to protect the troops in Vietnam (one endemic area ...
https://en.wikipedia.org/wiki/Karl_Friedrich_Meyer
Antimicrobial resistanceAntimicrobial resistance
Microorganisms usually do not develop resistance to vaccines because vaccines reduce the spread of the infection and target the ... "Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective". Scientific Reports. ... Development and testing of more effective vaccines is underway. Two registrational trials have evaluated vaccine candidates in ... Vaccine recipients who developed S. aureus infection were five times more likely to die than control recipients who developed S ...
https://en.wikipedia.org/wiki/Antimicrobial_resistance
List of University of Edinburgh peopleList of University of Edinburgh people
... discoverer of Brucella Min Chueh Chang, inventor of Combined oral contraceptive pill and pioneer in IVF, Lasker Award winner in ... developer of the HPV vaccine Dame Anne Glover FRS, Chief Scientific Adviser to the President of the European Commission from ...
https://en.wikipedia.org/wiki/List_of_University_of_Edinburgh_people
List of veterinariansList of veterinarians
Camille Guérin (1872-1961) - developed a vaccine for tuberculosis James Hallen (1829-1901) - British veterinarian who served as ... Danish veterinarian who discovered Brucella abortus Denis Barberet (1714-1770) - French bibliographer and author Harold William ...
https://en.wikipedia.org/wiki/List_of_veterinarians
HepatitisHepatitis
If the vaccine is for hepatitis A only, two doses are given 6-18 months apart depending on the manufacturer. If the vaccine is ... brucella species and campylobacter species. Chronic or granulomatous hepatitis is seen with infection from mycobacteria species ... There is also a combination formulation that includes both hepatitis A and B vaccines. There are currently no vaccines ... People in these groups who are not already immune can receive the hepatitis A vaccine. Those at high risk and in need of ...
https://en.wikipedia.org/wiki/Hepatitis
Browsing by Subject Brucella VaccineBrowsing by Subject "Brucella Vaccine"
Report of the WHO Informal Meeting on Oral/Conjunctival Brucellosis Strain 2 Vaccine, Nouzilly, France, 8-9 February 1989  ... The Development of new/improved brucellosis vaccines : report of a WHO meeting, Geneva, Switzerland, 11-12 December 1997  ... Report of the FAO/WHO Informal Meeting on Oral/Conjunctival Brucellosis Vaccine, Rome, Italy, 6-7 September 1988  ... Report of WHO Working Group Meeting on Oral/Conjunctival Brucellosis Strain 2 Vaccine, Rome, 2-4 October 1991  ...
https://extranet.who.int/iris/restricted/browse?authority=Brucella+Vaccine&type=mesh
Biosafety of parenteral Brucella abortus RB51 vaccine in bison calvesBiosafety of parenteral Brucella abortus RB51 vaccine in bison calves
Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x ... Before their use, however, vaccine safety and efficacy must be demonstrated. ... Biosafety of parenteral Brucella abortus RB51 vaccine in bison calves. Journal of Wildlife Management ... Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x ...
https://pubs.er.usgs.gov/publication/70021673
Transboundary Spread of Brucella canis through Import of Infected Dogs, the Netherlands, November 2016-December 2018 - Volume...
In: Manual of diagnostic tests and vaccines for terrestrial animals. 2018 [cited 2020 Mar 25]. https://www.oie.int/fileadmin/ ... Lucero NE, Corazza R, Almuzara MN, Reynes E, Escobar GI, Boeri E, et al. Human Brucella canis outbreak linked to infection in ... Egloff S, Schneeberger M, Gobeli S, Krudewig C, Schmitt S, Reichler IM, et al. Brucella canis infection in a young dog with ... Maio E, Begeman L, Bisselink Y, van Tulden P, Wiersma L, Hiemstra S, et al. Identification and typing of Brucella spp. in ...
https://wwwnc.cdc.gov/eid/article/27/7/20-1238
Browsing by SubjectBrowsing by Subject
Brucella Vaccine [‎6]‎. Brucellosis [‎103]‎. Brucellosis, Bovine [‎2]‎. Brugia [‎5]‎. Brugia malayi [‎1]‎. ...
https://apps.who.int/iris/browse?rpp=20&sort_by=-1&type=mesh&offset=749&etal=-1&order=ASC
Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine...Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine...
Brucella abortus S19 vaccine is a stable attenuated smooth strain, globally used as calfhood vaccine for the prevention of ... Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine ... Four vaccine doses of which the first dose consisted of full dose (40 × 109 CFU/dose) and the other three were 1/10th, 1/20th, ... Each vaccine dose was administered to 13 cattle calves of 4-5 months of age maintained in separate groups. The blood samples ...
https://pesquisa.bvsalud.org/brasil/resource/pt/mdl-37003120
Summary of Notifiable Diseases --- United States, 2005Summary of Notifiable Diseases --- United States, 2005
Brucella abortus strain RB51: a new brucellosis vaccine for cattle. Compendium 1997;19:766--74. ... The effectiveness of the mumps component of the MMR vaccine: a case control study. Vaccine 2005;23:4070--4. ... Brucellosis (Brucella melitensis, abortus, suis, and canis). Atlanta, GA: US Department of Health and Human Services, CDC; 2005 ... Vaccine-derived polioviruses and the endgame strategy for global polio eradication. Annu Rev Microbiol 2005; 59:587--635. Q ...
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5453a1.htm
Darrell Bayles : USDA ARSDarrell Bayles : USDA ARS
Genome report-a genome sequence analysis of the RB51 strain of Brucella abortus in the context of its vaccine properties. G3, ... paratuberculois protein cocktail vaccines in a mouse model - (Proceedings) Barnhill, A.E., Bannantine, J.P., Chang, Y., Osman, ... paratuberculosis protein cocktail vaccines in a mouse model - (Abstract Only) Barnhill, A.E., Bannantine, J.P., Chang, Y., ... Salmonella DIVA vaccine reduces disease, colonization and shedding due to virulent S. Typhimurium infection in swine - (Peer ...
https://www.ars.usda.gov/people-locations/person/?person-id=40343
WHO EMRO | Seroprevalence of Brucella species among women with miscarriage in Jordan | Volume 17, issue 11 | EMHJ volume 17,...
Seroprevalence of Brucella species among women with miscarriage in Jordan ... A review of the use of B. melitensis Rev 1 vaccine in adult sheep and goats. Preventive Veterinary Medicine, 1997, 31:275-283. ... In animals, Brucella spp. is an established major cause of miscarriage and serious economic loss to dairy and small ruminant ... The seroprevalence of Brucella spp. was reported as 8% among high risk people in Jordan [16]. According to Thrusfield [18], the ...
http://www.emro.who.int/emhj-volume-17/volume-17-issue-11/article-12.html
Publications at this Location : USDA ARSPublications at this Location : USDA ARS
HOST SPECIES DIFFERENCES IN RESPONSES TO BRUCELLA OR MYCOBACTERIUM VACCINES (Abstract Only) (4-Dec-05) ... Report of the Vaccine Working Group. Enhancing Brucellosis Vaccines, Vaccine Delivery, and Surveillance Diagnostics for Elk and ... DNA VACCINES AGAINST TUBERCULOSIS (Book / Chapter) (8-Dec-05) THE MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS GENOME AND ... SUSCEPTIBILITY OF BRUCELLA TO MACROLIDES: ANALYSES OF THE 23S RDNA, L4 AND L22 (Abstract Only) (22-Sep-05) ...
https://www.ars.usda.gov/research/publications/publications-at-this-location/?modecode=50-30-20-10&locpubs=yes&filterYear=2005
HAN Archive - 00417 | Health Alert Network (HAN)HAN Archive - 00417 | Health Alert Network (HAN)
Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. ... Notes from the Field: Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise ... This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U. ... Milk samples from the dairy tested positive for Brucella strain RB51. People who consumed raw milk or raw milk products from ...
https://emergency.cdc.gov/han/han00417.asp
سامانه نشر مجلات علمی دانشگاه تهران
Efficacy of Rev-1 Vaccine Against Brucella melitensis Infection in Dog. دوره 15، شماره 4، دی 2021، صفحه 387-394. ...
https://journals.ut.ac.ir/?_action=article&kw=2609&_kw=Dog
FL - Department of Agriculture & Consumer Services - Animal Disease Control | Animal Legal & Historical CenterFL - Department of Agriculture & Consumer Services - Animal Disease Control | Animal Legal & Historical Center
1) "Approved brucella vaccine" means a Brucella abortus immunization product approved and licensed by the United States ... vaccines, live microorganisms, killed microorganisms, and the antigenic or immunizing components of microorganisms intended for ... vaccine, or other therapeutic or prophylactic agent. ... e) Fowl laryngotracheitis vaccine;. (f) Anthrax spore vaccine; ...
https://www.animallaw.info/statute/fl-department-agriculture-consumer-services-animal-disease-control
NIOSHTIC-2 Search Results - Full View
... had accidentally self-injected vaccines containing live Brucella organisms. Inadvertent self-injection of vaccines, ... In a 1995 survey of 701 veterinarians, accidental self-injection of rabies virus vaccine was reported by 27% of respondents; ... the most commonly reported needlestick injury is inadvertent injection of a vaccine. ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27engineering%2A%27+%27control%2A%27&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=105&RecNo=1041&View=f&
HAN Archive - 00417 | Health Alert Network (HAN)HAN Archive - 00417 | Health Alert Network (HAN)
Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. ... Notes from the Field: Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise ... This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U. ... Milk samples from the dairy tested positive for Brucella strain RB51. People who consumed raw milk or raw milk products from ...
https://www.emergency.cdc.gov/han/HAN00417.asp
Laboratory Exposures to Brucellae and Implications for Bioterrorism - Volume 11, Number 8-August 2005 - Emerging Infectious...
... and laboratories that manufactured Brucella vaccines has also been documented (21,22). A laboratory technician at the Centers ... Brucellae are considered class 3 organisms. CDC has strongly recommended that live Brucella cultures and suspicious organisms ... and administration of influenza vaccine should be strongly recommended to all Brucella-exposed persons. If symptoms develop, ... Brucella canis. A cause of undulant fever. Am J Med. 1975;59:424-6. DOIPubMedGoogle Scholar ...
https://wwwnc.cdc.gov/eid/article/11/8/04-1197_article
View source for Immunology Ontologies and Their Applications in Processing Clinical Data - NCBO WikiView source for Immunology Ontologies and Their Applications in Processing Clinical Data - NCBO Wiki
... and its treatment of Brucella-host interaction. 16:30 Oliver He (University of Michigan) ::Contributions of the Vaccine ... VO is a community-based biomedical ontology in the domain of vaccine and vaccination. We will introduce the top level of VO, ... 10:45 Break 11:15 Oliver He (University of Michigan) ::How Flow Cytometry can be used in Vaccine Research :::To better ... Vaccine Ontology (Oliver He) :AO Allergy Ontology (Alex C. Yu) :ND Neurological Disease Ontology (Alexander Diehl) ---- == ...
https://www.bioontology.org/mediawiki/index.php?title=Immunology_Ontologies_and_Their_Applications_in_Processing_Clinical_Data&action=edit&oldid=12306
Scientists Discover How to Disarm Superbug BacteriasScientists Discover How to Disarm Superbug Bacterias
Fever-inducing Brucella isnt very contagious, and cases are rare, but its also very hard to treat and there isnt a vaccine. ... In other words Brucella is a superbug, but you dont have to worry about an experiment getting out of hand. The researchers ... In a study published in Chemistry & Biology, scientists describe how they managed to block Brucella from bonding with a host. ... we could effectively eliminate the virulence of Brucella regardless of whether or not a particular strain is drug resistant. So ...
https://gizmodo.com/scientists-discover-how-to-disarm-superbug-bacterias-5937363
Funded Research - PWD Foundation, Inc.Funded Research - PWD Foundation, Inc.
Evaluation of a New Vaccine for Canine Brucellosis. 2018. Canine infection by Brucella spp. constitutes a serious problem for ...
https://www.pwdfoundation.org/research/funded-research/page/4/
List of Publications from OWH Supported Studies | FDAList of Publications from OWH Supported Studies | FDA
Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus. Vaccine 2002; 20(9-10):1445-50. ... Systemic and mucosal immunity in rhesus macaques immunized with HIV-1 peptide and gp120 conjugated to Brucella abortus. J Med ...
https://www.fda.gov/science-research/womens-health-research/list-publications-owh-supported-studies
CDC says it improperly sent dangerous pathogens in five incidents in past decade - The Washington PostCDC says it improperly sent dangerous pathogens in five incidents in past decade - The Washington Post
In 2009, newly available test methods show that a strain of Brucella, which can cause a highly contagious bacterial infection ... had been shipped to outside laboratories as early as 2001 because researchers believed mistakenly that it was a vaccine strain ...
https://www.washingtonpost.com/national/health-science/cdc-says-it-improperly-sent-dangerous-pathogens-in-five-incidents-in-past-decade/2014/07/11/acd55bfc-0882-11e4-a0dd-f2b22a257353_story.html?utm_term=.64ab932f9a34
CDC Investigation of Brucella abortus RB51 Infection Linked to Pennsylvania DairyCDC Investigation of Brucella abortus RB51 Infection Linked to Pennsylvania Dairy
Lyme Disease Vaccine Shows Antibodies 6 Months after Completion. FDA Expands Ibrexafungerp Approval for Reduction of Recurrent ... A case of Brucella abortus RB51 infection in 2018 was traced back to a Pennsylvania dairy, raising concerns about the risk of ... The CDC launched an investigation of exposure to the Brucella abortus RB51 strain last year. No other cases of brucellosis were ... The cow, which had received the vaccine in 2011 and was purchased by the dairy in 2016, was taken out of production. Subsequent ...
https://www.contagionlive.com/view/cdc-investigation-of-brucella-abortus-rb51-infection-linked-to-pennsylvania-dairy
Publication year rev: 7984-2016 / Subject: 3 selected / Subject term: Mirounga - PubAg Search ResultsPublication year rev: 7984-2016 / Subject: 3 selected / Subject term: Mirounga - PubAg Search Results
Brucella Remove constraint Subject: Brucella Subject Phocine morbillivirus Remove constraint Subject: Phocine morbillivirus ... vaccine adjuvants; Toll-like receptor 1. Abstract:. ... Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key ... Mirounga; endangered species; methicillin-resistant Staphylococcus aureus; marine mammals; population dynamics; Brucella; risk ...
https://pubag.nal.usda.gov/?f%5Bpublication_year_rev%5D%5B%5D=7984-2016&f%5Bsubject_facet%5D%5B%5D=Phoca+vitulina&f%5Bsubject_facet%5D%5B%5D=Brucella&f%5Bsubject_facet%5D%5B%5D=Phocine+morbillivirus&f%5Bsubject_term%5D%5B%5D=Mirounga&per_page=20&search_field=author&sort=date-asc
No comments yetNo comments yet
About Brucella. RB51 is a weakened strain of Brucella abortus bacteria used to vaccinate young female cattle. Intensive ... The bovine vaccine reduces the risk of people contracting brucellosis from infected cows. However, in rare cases, vaccinated ... The Brucella RB51 strain is resistant to some antibiotics that would normally be used to prevent or treat brucellosis. ... While Brucella can cause anyone to become sick, women may suffer miscarriage and other pregnancy complications making it ...
https://www.newfoodmagazine.com/news/46612/rare-potentially-deadly-bacteria-found-us-milk/
Seeking a niche<...Seeking a niche<...
keywords = "Animals, Bacterial Proteins, Bacterial Vaccines, Brucella, Host Factor 1 Protein, Intracellular Fluid, Macrophages ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ...
https://abdn.pure.elsevier.com/en/publications/seeking-a-niche
IntroductionIntroduction
Brucella abortus. Vaccine strain RB51. 05-07-2003. Burkholderia pseudomallei. Bp82 (a Δ. purM. mutant of strain 1026b). 04-14- ... Vaccine candidate strain ΔNSs-ΔNSm-ZH501. 03-12-2012. SARS-Coronavirus. NATtrol™ treated SARS-CoV molecular controls. 02-08- ... Bacillus anthracis, Brucella. spp., Mycobacterium tuberculosis, Salmonella typhi, Shigella dysenteriae. 4. An organism that ... LVS (live vaccine strain; includes NDBR 101 lots, TSI-GSD lots, and ATCC 29684). 02-27-2003. ...
https://stacks.cdc.gov/view/cdc/27143/cdc_27143_DS2.txt
JournalTOCs
Brucella abortus A19 vaccine on a dairy farm undergoing an abortion. outbreak in China*. Authors: Yu Wang; Yan Wang, Qingjie ...
https://www.journaltocs.ac.uk/index.php?action=browse&subAction=subjects&publisherID=76&journalID=47065&pageb=4&userQueryID=&sort=&local_page=1&sorType=&sorCol=
Prevention Guidelines TitlesPrevention Guidelines Titles
Current Trends Rabies Vaccine, Adsorbed: A New Rabies Vaccine for Use in Humans; 1988:04:15. Agent Summary Statement for Human ... Human Exposure to Brucella abortus Strain RB51 -- Kansas, 1997; 1998:03:13. Administration of Zidovudine During Late Pregnancy ... Decreased Antibody Response to Influenza Vaccine Among Nursing-Home Residents Who Received Recalled Vaccine -- New York, 1996; ... Rabies Postexposure Prophylaxis with Human Diploid Cell Rabies Vaccine: Lower Neutralizing Antibody Titers with Wyeth Vaccine; ...
https://wonder.cdc.gov/wonder/prevguid/titles_d.html
InfectionRB51MelitensisLive-attenuatedAbortus vaccineCanisPathogenAntigensIntracellularExposureAbstract2018BacterialVaccinationSpeciesCattleICAREfficacyInadvertentHumansBacteriaVacunaPathogensImmunityInfections1991Terrestrial animalsOrganismsCandidateImmune responsesProteinInvestigation2016SubunitOntologyBovine brucellosisImmunizationPregnant women10.1016InteractionsClinical trialsLaboratoryCampylobacterRoughHostsCandidates
Infection9
  • ABSTRACT Results differ as to whether Brucella infection during pregnancy increases a woman's risk of miscarriage. (who.int)
  • Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise County, Texas, 2017. (cdc.gov)
  • Canine infection by Brucella spp. (pwdfoundation.org)
  • A case of Brucella abortus RB51 infection in 2018 was traced back to a Pennsylvania dairy, raising concerns about the risk of infections from drinking raw milk. (contagionlive.com)
  • In this study, patho-physiological response to Brucella abortus S19Δper infection in BALB/c mice was assessed in comparison to its parent strain, B. abortus S19 and virulent strain, B. abortus 544. (who.int)
  • The current vaccine strain, RB51, is able to induce protection from natural brucellosis infection in cattle but not in wildlife. (uwyo.edu)
  • 2015. Host Response to Brucella Infection : Review and Future perspective. (unair.ac.id)
  • These studies are principally targeted on the understanding of the response to infection by the host and elucidating the correlates of protective immunity elicited by the encapsulated and non-encapsulated vaccines. (tamu.edu)
  • Brucellosis is a disease caused by infection with bacteria of the genus Brucella. (atlasofscience.org)
RB5117
  • Exposure to the Brucella abortus RB51 culture for confirmation ( 1 ). (cdc.gov)
  • These cases abortus strain RB51 vaccine (RB51) to cattle 3 weeks before highlighted the lack of awareness of the unique challenges in symptom onset. (cdc.gov)
  • OPHD and cians unfamiliar with management of human RB51 Brucella the local health jurisdiction provided RB51-specific treatment infections and exposures. (cdc.gov)
  • Adverse events in humans ity in humans, he had not sought the recommended postexpo- associated with accidental exposure to the livestock brucellosis vaccine RB51. (cdc.gov)
  • Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x 1010 colony forming units [CFU], subcutaneously) as part of routine management. (usgs.gov)
  • The New York State Department of Health and Pennsylvania Department of Health are investigating Brucella RB51 exposures that may be connected to consuming raw (unpasteurized) milk from Miller's Biodiversity Farm in Quarryville, Pennsylvania. (cdc.gov)
  • This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U.S., since August 2017. (cdc.gov)
  • Milk samples from the dairy tested positive for Brucella strain RB51. (cdc.gov)
  • Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. (cdc.gov)
  • However, there have now been three documented cases of brucellosis caused by Brucella abortus RB51 linked to consumption of unpasteurized milk since 2017. (contagionlive.com)
  • The CDC launched an investigation of exposure to the Brucella abortus RB51 strain last year. (contagionlive.com)
  • We want to prevent infections by making sure people understand the risk of serious infections when consuming unpasteurized milk," Gruber said "We will also continue to look for any new Brucella abortus RB51 infections. (contagionlive.com)
  • Now the CDC have warned anyone who drank the product from a company called Udder Milk that they may too have been infected with the bacteria Brucella abortus RB51. (newfoodmagazine.com)
  • CDC confirmed her illness was Brucella RB51 in late October. (newfoodmagazine.com)
  • The Brucella RB51 strain is resistant to some antibiotics that would normally be used to prevent or treat brucellosis. (newfoodmagazine.com)
  • RB51 is a weakened strain of Brucella abortus bacteria used to vaccinate young female cattle. (newfoodmagazine.com)
  • The heat of pasteurisation kills RB51, other types of Brucella, and a variety of other disease-causing bacteria. (newfoodmagazine.com)
Melitensis3
  • Different fractions of Brucella (B) abortus or Brucella melitensis have been used as antigens for the detection of anti-Brucella antibodies in goat sera, being their accomplishment cumbersome and time consuming. (gob.ar)
  • Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. (gob.ar)
  • 2010. Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens. (unair.ac.id)
Live-attenuated2
  • The case, detailed in a recent Morbidity and Mortality Weekly Report , involved a New York patient who contracted brucellosis from the live attenuated vaccine strain of B. abortus used to prevent brucellosis in cattle. (contagionlive.com)
  • Nevertheless, we present a strategy towards the production of low-cost "live-attenuated multivalent vaccine factories" with the ability to express glycoconjugates in poultry. (biomedcentral.com)
Abortus vaccine1
  • Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats. (bvsalud.org)
Canis2
  • Brucella canis had not been isolated in the Netherlands until November 2016, when it was isolated from a dog imported from Romania. (cdc.gov)
  • In general, B. canis appears to cause less severe clinical symptoms in humans than other Brucella spp. (cdc.gov)
Pathogen5
  • We have developed VO-based natural language processing (NLP) approaches to retrieve and analyze vaccine-specific interaction networks of host or pathogen genes. (stanford.edu)
  • and (3) VO-based literature mining provided better performance than the MeSH-based PubMed approach in retrieving the interactions between vaccines and genes from Brucella (a bacterial pathogen). (stanford.edu)
  • His group has also developed and applied ontology-based literature mining tools to study biological pathways with an emphasis on vaccine-associated gene interaction networks among host and pathogen genes. (stanford.edu)
  • Glycoconjugate vaccines, which consist of an immunogenic protein covalently coupled to glycan antigens of the targeted pathogen, have a proven track record in human vaccinology, but have yet to be used for livestock due to prohibitively high manufacturing costs. (biomedcentral.com)
  • 3) Vaccine informatics, host-pathogen interactions, and vaccine/drug design and safety analysis. (hegroup.org)
Antigens2
  • VO also represents all types of vaccine components (e.g., vaccine antigens and adjuvants) and vaccine preparations. (stanford.edu)
  • As described below, we applied our own reverse vaccinology and mechine learning methods to predict COVID-19 vaccine antigens . (hegroup.org)
Intracellular1
  • Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the rhizobia to establish and maintain protracted intracellular residence in their plant host and those used by the brucellae during their long-term survival in the phagosomal compartment of host macrophages. (elsevier.com)
Exposure2
  • Discovery of a laboratory exposure to brucellae should prompt an exhaustive investigation of the event and its circumstances, definition of the population at risk, enforcement of safe laboratory practices, and antimicrobial drug prophylaxis for exposed persons. (cdc.gov)
  • When the exposure of the vaccine industry's abuses and failures finally happens, will we treat it with the same ho-hum indifference that we show for the ever-growing list of Pharma drug crimes? (badlymeattitude.com)
Abstract1
  • ABSTRACT: The Vaccine Ontology (VO, http://www.violinet.org/vaccineontology) is a community-based biomedical ontology in the domain of vaccine and vaccination. (stanford.edu)
20182
Bacterial4
  • Seeded media harbor considerable amounts of viable Brucella organisms, and routine bacteriologic procedures such as preparing, centrifuging, and vigorous agitation (vortexing) of bacterial suspensions, performing subcultures and biochemical testing, and particularly the catalase test, may create dangerous aerosols and the potential for accidental spillage ( 14 ). (cdc.gov)
  • These vaccines have been developed against infections of various bacterial, viral, and parasitic pathogens as well as cancers in over 20 animal species. (stanford.edu)
  • A bacterial vaccine for the prevention of brucellosis in man and animal. (bvsalud.org)
  • To overcome this, we use Protein Glycan Coupling Technology (PGCT), which enables the production of glycoconjugates in bacterial cells at considerably reduced costs, to generate a candidate glycan-based live vaccine intended to simultaneously protect against Campylobacter jejuni , avian pathogenic Escherichia coli (APEC) and Clostridium perfringens . (biomedcentral.com)
Vaccination3
  • The blood samples were collected on 0 to 240 days post- vaccination (DPV) at the intervals of 0, 14, 28, 45, 60, 90, 150, 180 and 240 for assessment of vaccine -induced innate, humoral and cell -mediated immune responses . (bvsalud.org)
  • Despite section 7, a vaccine to be administered as part of a vaccination operation under the Public Health Act (chapter S-2.2) may be sold without prescription to a nurse for professional use. (gouv.qc.ca)
  • The Vaccine Ontology (VO) has become a community effort for standard representation of vaccines, vaccine components, vaccination, and host responses to vaccines. (hegroup.org)
Species2
  • https://doi.org/10.3201/eid1707.110222 sidered atypical Brucella species similar to B. microti and 10. (cdc.gov)
  • Most of Brucella species are capable of infecting humans, and they are all considered zoonotic since different animals are their preferential hosts. (atlasofscience.org)
Cattle4
  • Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India. (bvsalud.org)
  • Various agencies demonstrated different doses for vaccinating cattle and buffalo calves leading to ambiguity in selecting a suitable immune vaccine dose . (bvsalud.org)
  • Each vaccine dose was administered to 13 cattle calves of 4-5 months of age maintained in separate groups. (bvsalud.org)
  • Brucella abortus is the etiological agent of brucellosis in cattle and elk and is known to cause abortion, sterility and decreased milk production. (uwyo.edu)
ICAR1
  • Hester has signed the agreement towards receiving the indigenously developed technology from ICAR-IVRI (Indian Council of Agriculture Research - Indian Veterinary Research Institute), for developing the Brucella Abortus S19 Delta Per vaccine. (agrinnovateindia.co.in)
Efficacy2
  • Before their use, however, vaccine safety and efficacy must be demonstrated. (usgs.gov)
  • We incorporate the microencapsulation technology to increase safety and efficacy of vaccines for human and animal use. (tamu.edu)
Inadvertent3
  • the most commonly reported needlestick injury is inadvertent injection of a vaccine. (cdc.gov)
  • Inadvertent self-injection of vaccines, antimicrobials, and anesthetic agents by veterinary personnel may result in adverse events that range from local irritation to serious systemic reactions. (cdc.gov)
  • Inadvertent exposures to brucellae in the clinical laboratory indicate a widespread lack of preparedness to cope with eventual biologic threats involving use of the organism. (cdc.gov)
Humans2
  • Several biologic characteristics make brucellae easily transmissible within the close confinement of the clinical microbiology laboratory, including the facts that the infecting dose for humans is low, and the organism may enter the body in many ways relevant to laboratory practices (e.g., through the respiratory mucosa, conjunctivae, gastrointestinal tract, or abraded skin) ( 1 , 2 ). (cdc.gov)
  • Atypical Brucella lesions in humans, an outbreak of glanders in Bahrain suggests multiple wild mammals, amphibians, and fish range from lo- introduction events. (cdc.gov)
Bacteria1
  • The researchers found that bacteria like Brucella need the protein VirB8 to latch on. (gizmodo.com)
Vacuna3
  • Elaboraci'on y normalizaci'on de la vacuna brucella abortus, cepa 19. (who.int)
  • Vacuna bacteriana para la prevención de la brucelosis en humanos y animales. (bvsalud.org)
  • La vacuna de Brucella abortus se utiliza para la inmunización del ganado bovino, ovino y caprino. (bvsalud.org)
Pathogens1
  • We generated a candidate glycan-based multivalent live vaccine with the potential to induce protection against key avian and zoonotic pathogens ( C. jejuni , APEC, C. perfringens ). (biomedcentral.com)
Immunity1
  • This study was designed to evaluate a protein from B. abortus that may potentially make an excellent candidate for induction of protective immunity and a possible subunit vaccine candidate. (uwyo.edu)
Infections4
  • In pregnant patients, Brucella infections can be associated with miscarriage. (cdc.gov)
  • Conclusion: All the data suggested that the mAb (N06) can be used as diagnostic reagents for PRRSV detection, while the recognized linear epitope can be useful in epitope-based vaccines development, which is helpful for the control of local PRRSV infections in swine. (bvsalud.org)
  • Low-cost vaccines that can be combined to protect poultry against multiple infections are a current global imperative. (biomedcentral.com)
  • dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening disease that is frequently fatal, for which there are no vaccines or treatments, or a related agent with unknown risk of transmission. (absa.org)
19911
  • 1991. Determination of Brucella Immunoglobulin G Agglutinating Antibody Titer with Dithiothretol. (unair.ac.id)
Terrestrial animals1
  • In: Manual of diagnostic tests and vaccines for terrestrial animals. (cdc.gov)
Organisms3
  • among large-animal practice respondents, 23% had accidentally self-injected vaccines containing live Brucella organisms. (cdc.gov)
  • Brucellae are class 3 organisms and potential agents of bioterrorism. (cdc.gov)
  • The concentration of Brucella organisms in the blood ( 11 , 12 ) and synovial fluid ( 13 ) of patients with brucellosis is usually low, and therefore, these clinical specimens probably pose a low risk for contagion for laboratory personnel. (cdc.gov)
Candidate3
  • S19Δper, thus could be a safer vaccine candidate as an alternate to the S19 vaccine strain. (who.int)
  • The aim of this study was design of a novel multi-epitope vaccine (MEV) candidate against the CHIKV structural proteins using comprehensive immunoinformatics and immune simulation analyses. (bvsalud.org)
  • The described characteristics of BLS make this protein an excellent candidate for vaccine development. (conicet.gov.ar)
Immune responses1
  • In addition, various vaccine-induced immune responses and protection against specific disorders are being modeled in VO. (stanford.edu)
Protein1
  • But if scientists can figure out how to inhibit the protein in the human body, we could effectively eliminate the virulence of Brucella regardless of whether or not a particular strain is drug resistant. (gizmodo.com)
Investigation1
  • The patient reported having investigation of cases and exposures after raw (unpasteurized) sustained a needle stick while administering the Brucella milk consumption in Texas and New Jersey ( 4 , 5 ). (cdc.gov)
20161
  • The cow, which had received the vaccine in 2011 and was purchased by the dairy in 2016, was taken out of production. (contagionlive.com)
Subunit1
  • Finally, 4 CTL and HTL each while 6 B cell 16-mers were used for designing multiepitope subunit (MSV) and mRNA vaccine joined via suitable linkers. (bvsalud.org)
Ontology3
  • The next NCBO Webinar will be presented May 2 by Oliver He from the University of Michigan Medical School on "Vaccine Ontology (VO) and its application in literature mining of vaccine-gene interaction networks" at 10:00am PT, Wednesday, May 2. (stanford.edu)
  • Dr. He is also an active developer of the Ontology for Biomedical Investigations (OBI), which is collaboratively developed by over 20 communities, and Dr. He is the representation of the vaccine community. (hegroup.org)
  • We have also applied the Vaccine Ontology (VO) and CIDO to model, represent, and analyze COVID-19 vaccines, and are currently developing a COVID-19 vaccine knowledgebase (Cov19VaxKB) . (hegroup.org)
Bovine brucellosis1
  • Brucella abortus S19 vaccine is a stable attenuated smooth strain , globally used as calfhood vaccine for the prevention of bovine brucellosis . (bvsalud.org)
Immunization1
  • Immunization with strain 19, the first vaccine to be developed and used, is highly reactogenic and not recommended for use in wildlife. (uwyo.edu)
Pregnant women1
  • While Brucella can cause anyone to become sick, women may suffer miscarriage and other pregnancy complications making it critical for pregnant women who may have consumed the raw milk from Udder Milk to seek medical care immediately. (newfoodmagazine.com)
10.10161
  • https://doi.org/10.1016/j.vaccine.2006.07.046 Full text not available from this repository. (lshtm.ac.uk)
Interactions1
  • 2003. Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum, 198(4). (unair.ac.id)
Clinical trials2
  • VO represents over 1,000 licensed vaccines and vaccine candidates in clinical trials and in research. (stanford.edu)
  • Why in News Recently, India has started phase I/II clinical trials of Covid-19 vaccine - ZyCoV-D, designed and developed by Zydus (a pharmaceutical. (drishtiias.com)
Laboratory2
  • When ordering blood cultures to diagnose brucellosis, please advise the laboratory that blood culture may grow Brucella and that appropriate laboratory containment and precautions should be observed. (cdc.gov)
  • My laboratory is interested in the development of vaccines against select agents focusing onBrucella spp. (tamu.edu)
Campylobacter1
  • The live vaccine failed to significantly reduce Campylobacter colonisation under the conditions tested but was protective against homologous APEC challenge. (biomedcentral.com)
Rough1
  • a stable rough strain of Brucella abortus . (cdc.gov)
Hosts1
  • Long-term residence of the brucellae in the phagosomal compartment of host macrophages is essential to their ability to produce disease in both natural and experimental hosts. (elsevier.com)
Candidates1
  • We have also used these tools to predict COVID-19 vaccine candidates . (hegroup.org)
People in Four States May Be Drinking Contaminated Raw Milk | CDC Online Newsroom | CDC
People in Four States May Be Drinking Contaminated Raw Milk | CDC Online Newsroom | CDC (cdc.gov)
Notes from the Field: Adverse Event Associated with Unintentional Exposure to the Brucella abortus RB51 Vaccine - Oregon,...
Notes from the Field: Adverse Event Associated with Unintentional Exposure to the Brucella abortus RB51 Vaccine - Oregon,... (cdc.gov)
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Notes from the Field: Brucella abortus Vaccine Strain RB51 Infection and Exposures Associated with Raw Milk Consumption - Wise...
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Summary of Notifiable Diseases --- United States, 2005
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Summary of Notifiable Diseases --- United States, 2003
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Summary of Notifiable Diseases --- United States, 2004
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Summary of Notifiable Diseases --- United States, 2006
Summary of Notifiable Diseases --- United States, 2006 (cdc.gov)
Notes from the Field: Brucella abortus RB51 Infections Associated with Consumption of Raw Milk from Pennsylvania - 2017 and...
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HAN Archive - 00417 | Health Alert Network (HAN)
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CDC | Public Health Law Anthologies: Raw Milk
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Summary of Notifiable Diseases --- United States, 2002
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Brucellosis Treatment & Management: Approach Considerations, Initial Supportive Care, Pharmacologic Therapy
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