Brucella Vaccine
Brucella
Brucellosis
Brucella abortus
Brucella melitensis
Vaccines
Vaccines, Inactivated
Viral Vaccines
Bacterial Vaccines
Vaccines, DNA
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Vaccines, Synthetic
Brucella canis
AIDS Vaccines
Brucellosis, Bovine
Vaccines, Subunit
Vaccines, Conjugate
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
Vaccination
Malaria Vaccines
Papillomavirus Vaccines
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Immunity to Brucella in mice vaccinated with a fraction (F8) or a killed vaccine (H38) with or without adjuvant. Level and duration of immunity in relation to dose of vaccine, recall injection and age of mice. (1/138)
Immunity to Brucella in the mouse, assessed by bacterial spleen counts 15 days after intraperitoneal inoculation of a standard challenge of B. abortus 544, has been studied with two vaccines, one experimental, composed of a fraction of the bacterial cell-wall (F8) extracted from B. abortus 99, the other of killed whole bacteria, B. melitensis 53 H38, taken as reference (H38). The level of primary immunity depended on the dose of vaccine, the presence of oil adjuvant and the age of the mouse. The presence of adjuvant enabled the immunization to F8 to continue beyond the first month, to reach its maximum around the fourth month, and to remain stable for at least 7 months. A booster injection 3 or 6 months after the primary vaccination reinforced existing immunity but did not increase it beyond a certain level. The effect of the recall injection was clearly demonstrated with low doses which gave a lower level of primary immunity. (+info)Antibody response to antigens distinct from smooth lipopolysaccharide complex in Brucella infection. (2/138)
The smooth lipopolysaccharide complex of the outer surface of smooth Brucella abortus cells is believed to be the antigenic component involved in serological tests routinely used for the diagnosis of brucellosis. Sera from cattle vaccinated or infected with B. abortus generally contain antibody directed toward the smooth lipopolysaccharide complex. The brucella organism contains a large number of other antigenically distinct components. The biological significance of some of these antigens has been demonstrated by showing that sera from infected cattle have precipitins to these components. These sera revealed up to seven distinct lines in immunoelectrophoresis with a protein-rich antigen mixture prepared from rough strain B. abortus 45/20, whereas sera from strain 19-vaccinated cattle did not reveal these lines at 4 or more months after vaccination. Monospecific antisera were prepared against six antigens in this mixture, and the purification of two of them by antibody affinity chromatography is described. (+info)Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK). (3/138)
Human brucellosis can be acquired from infected animal tissues by ingestion, inhalation, or contamination of the conjunctiva or traumatized skin by infected animal products. A vaccine to protect humans from occupational exposure or from zoonotic infection in areas where the disease is endemic would reduce an important cause of morbidity worldwide. Vaccines currently used in animals are unsuitable for human use. We tested a live, attenuated, purine-auxotrophic mutant strain of Brucella melitensis, WR201, for its ability to elicit cellular and humoral immune responses and to protect mice against intranasal challenge with B. melitensis 16M. Mice inoculated intraperitoneally with WR201 made serum antibody to lipopolysaccharide and non-O-polysaccharide antigens. Splenocytes from immunized animals released interleukin-2 (IL-2), gamma interferon, and IL-10 when cultured with Brucella antigens. Immunization led to protection from disseminated infection but had only a slight effect on clearance of the challenge inoculum from the lungs. These studies suggest that WR201 should be further investigated as a vaccine to prevent human brucellosis. (+info)Complement fixation test to assess humoral immunity in cattle and sheep vaccinated with Brucella abortus RB51. (4/138)
The live attenuated Brucella abortus strain RB51 is a rifampin-resistant, lipopolysaccharide (LPS) O-chain-deficient mutant of virulent B. abortus 2308. The reduced O-chain content in RB51 prevents this bacterium from inducing antibodies detectable by the conventional serologic tests for bovine brucellosis diagnosis that mainly identify antibodies to LPS. The absence of available serologic tests for RB51 also complicates the diagnosis of possible RB51 infections in humans exposed to this strain. The purpose of this study was to evaluate the suitability of a complement fixation (CF) test performed with the rough strain B. abortus RB51, previously deprived of anticomplementary activity, in detecting anti-B. abortus RB51 antibodies in cattle and sheep experimentally vaccinated with this strain. The results of this study showed that a CF test with RB51 as the antigen is able to specifically detect antibodies following RB51 vaccination in cattle and sheep. In addition, this method could be a useful tool for detecting B. abortus RB51 infection in humans. (+info)Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51. (5/138)
Brucella abortus strain RB51 is an attenuated rough strain that is currently being used as the official live vaccine for bovine brucellosis in the United States and several other countries. We reasoned that overexpression of a protective antigen(s) of B. abortus in strain RB51 should enhance its vaccine efficacy. To test this hypothesis, we overexpressed Cu/Zn superoxide dismutase (SOD) protein of B. abortus in strain RB51. This was accomplished by transforming strain RB51 with a broad-host-range plasmid, pBBR1MCS, containing the sodC gene along with its promoter. Strain RB51 overexpressing SOD (RB51SOD) was tested in BALB/c mice for its ability to protect against challenge infection with virulent strain 2308. Mice vaccinated with RB51SOD, but not RB51, developed antibodies and cell-mediated immune responses to Cu/Zn SOD. Strain RB51SOD vaccinated mice developed significantly (P < 0.05) more resistance to challenge than those vaccinated with strain RB51 alone. The presence of the plasmid alone in strain RB51 did not alter its vaccine efficacy. Also, overexpression of SOD did not alter the attenuation characteristic of strain RB51. (+info)Brucella abortus strain RB51 as a vector for heterologous protein expression and induction of specific Th1 type immune responses. (6/138)
Brucella abortus strain RB51 is a stable, rough, attenuated mutant widely used as a live vaccine for bovine brucellosis. Our ultimate goal is to develop strain RB51 as a preferential vector for the delivery of protective antigens of other intracellular pathogens to which the induction of a strong Th1 type of immune response is needed for effective protection. As a first step in that direction, we studied the expression of a foreign reporter protein, beta-galactosidase of Escherichia coli, and the 65-kDa heat shock protein (HSP65) of Mycobacterium bovis in strain RB51. We cloned the promoter sequences of Brucella sodC and groE genes in pBBR1MCS to generate plasmids pBBSODpro and pBBgroE, respectively. The genes for beta-galactosidase (lacZ) and HSP65 were cloned in these plasmids and used to transform strain RB51. An enzyme assay in the recombinant RB51 strains indicated that the level of beta-galactosidase expression is higher under the groE promoter than under the sodC promoter. In strain RB51 containing pBBgroE/lacZ, but not pBBSODpro/lacZ, increased levels of beta-galactosidase expression were observed after subjecting the bacteria to heat shock or following internalization into macrophage-like J774A.1 cells. Mice vaccinated with either of the beta-galactosidase-expressing recombinant RB51 strains developed specific antibodies of predominantly the immunoglobulin G2a (IgG2a) isotype, and in vitro stimulation of their splenocytes with beta-galactosidase induced the secretion of gamma interferon (IFN-gamma), but not interleukin-4 (IL-4). A Th1 type of immune response to HSP65, as indicated by the presence of specific serum IgG2a, but not IgG1, antibodies, and IFN-gamma, but not IL-4, secretion by the specific-antigen-stimulated splenocytes, was also detected in mice vaccinated with strain RB51 containing pBBgroE/hsp65. Studies with mice indicated that expression of beta-galactosidase or HSP65 did not alter either the attenuation characteristics of strain RB51 or its vaccine efficacy against B. abortus 2308 challenge. (+info)Structural, functional and immunological studies on a polymeric bacterial protein. (7/138)
The characterization of proteins from Brucella spp, the causative agent of brucellosis, has been the subject of intensive research. We have described an 18-kDa cytoplasmic protein of Brucella abortus and shown the potential usefulness of this protein as an antigen for the serologic diagnosis of brucellosis. The amino acid sequence of the protein showed a low but significant homology with that of lumazine synthases. Lumazine is an intermediate product in bacterial riboflavin biosynthesis. The recombinant form of the 18-kDa protein (expressed in E. coli) folds like the native Brucella protein and has lumazine-synthase enzymatic activity. Three-dimensional analysis by X-ray crystallography of the homolog Bacillus subtilis lumazine synthase has revealed that the enzyme forms an icosahedral capsid. Recombinant lumazine synthase from B. abortus was crystallized, diffracted X rays to 2.7-A resolution at room temperature, and the structure successfully solved by molecular replacement procedures. The macromolecular assembly of the enzyme differs from that of the enzyme from B. subtilis. The Brucella enzyme remains pentameric (90 kDa) in its crystallographic form. Nonetheless, the active sites of the two enzymes are virtually identical at the structural level, indicating that inhibitors of these enzymes could be viable pharmaceuticals across a broad species range. We describe the structural reasons for the differences in their quaternary arrangement and also discuss the potential use of this protein as a target for the development of acellular vaccines. (+info)Validation of the abbreviated Brucella AMOS PCR as a rapid screening method for differentiation of Brucella abortus field strain isolates and the vaccine strains, 19 and RB51. (8/138)
The Brucella AMOS PCR assay was previously developed to identify and differentiate specific Brucella species. In this study, an abbreviated Brucella AMOS PCR test was evaluated to determine its accuracy in differentiating Brucella abortus into three categories: field strains, vaccine strain 19 (S19), and vaccine strain RB51/parent strain 2308 (S2308). Two hundred thirty-one isolates were identified and tested by the conventional biochemical tests and Brucella AMOS PCR. This included 120 isolates identified as B. abortus S19, 9 identified as B. abortus strain RB51, 57 identified as B. abortus biovar 1, 15 identified as B. abortus bv. 2, 1 identified as B. abortus bv. 2 (M antigen dominant), 7 identified as B. abortus bv. 4, and 22 identified as B. abortus S2308 and isolated from experimentally infected cattle. The Brucella AMOS PCR correctly identified each isolate as RB51/S2308, S19, or a field strain of Brucella. (+info)Expression and Localization of Green Fluorescent Protein in B. abortus strain RB51 - OpenThesis
Immunogens of Brucella Abortus S19 Identified By Two-Dimensional Gel Electrophoresis and Immunoblotting
Evaluation fo Live Attenuated B. Melitensis Vaccines in Nonhuman Primates - Thomas Ficht
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Title page for ETD etd-05192003-110707
Draft Genome Sequences of Two Brucella abortus Strains Isolated from Cattle and Pig [Abstract]
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nanM - N-acetylneuraminate epimerase precursor - Brucella abortus (strain 2308) - nanM gene & protein
KEGG PATHWAY: Ubiquinone and other terpenoid-quinone biosynthesis - Brucella abortus S19
Overview of small animal brucellosis control strategies - English
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Immune mechanisms in murine brucellosis : studies with strain RB51, a rough mutant of Brucella abortus
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O-chain expression in the rough Brucella melitensis strain B115: induction of O-polysaccharide-specific monoclonal antibodies...
Genome Sequence of Brucella abortus Vaccine Strain S19 Compared to Virulent Strains Yields Candidate Virulence Genes
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
Brucella suis vjbR polyclonal antibody - (PAB16064) - Products - Abnova
Attenuation and immunogenicity of a Brucella abortus htrA cycL double by Matthew Edmonds, Natha Booth et al.
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1...
Frontiers | TLR7 and TLR3 Sense Brucella abortus RNA to Induce Proinflammatory Cytokine Production but They Are Dispensable for...
Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
Relapsing brucella hepatitis due to Brucella abortus following doxycycline-streptomycin treatment [Medeniyet Med J]
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
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Brucella BvrR protein
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Frontiers | Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and...
Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with...
Presence of two independent chromosomes in the Brucella melitensis 16M genome. | Journal of Bacteriology
foodproof Brucella Detection Kit
Dendogram of global Brucella abortus biovar 1 genotypes | Open-i
Heat-stress-modulated induction of NF-κB leads to brucellacidal pro-inflammatory defense against Brucella abortus infection in...
Genetic Characterization of a Tn5-Disrupted Glycosyltransferase Gene Homolog in Brucella abortus and Its Effect on...
Brucella infection - including symptoms, treatment and prevention :: SA Health
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
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Induction of the Unfolded Protein Response by Brucella abortus VceC - Renee Tsolis
Molecular targets for rapid identification of Brucella spp
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Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51
Penggunaan Imunostik sebagai Uji Serologi untuk Deteksi Brucella abortus pada Sapi (APPLICATION IMMUNOSTICK ASSAY FOR...
Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene...
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The outer membranes of Brucella spp. are not barriers to hydrophobic permeants. | Journal of Bacteriology
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In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31...
ICD-10 Diagnosis Code A23.0 Brucellosis due to Brucella melitensis
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KEGG GENOME: Brucella abortus 2308
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Brucella inopinata
"Serological Diagnosis of Brucella Infections in Odontocetes". Clinical and Vaccine Immunology. 16 (6): 906-915. doi:10.1128/CVI ... LPSN "Brucella inopinata" at the Encyclopedia of Life Type strain of Brucella inopinata at BacDive - the Bacterial Diversity ... Brucella inopinata is a Gram-negative, nonmotile, non-spore-forming coccoid bacterium, first isolated from a breast implant ... "Taxonomy of Brucella." Open Veterinary Science Journal 4.1 (2010): 85-101. Fischer, Dominik; Lorenz, Nadja; Heuser, Wenke; ...
Brucella ceti
"Serological diagnosis of Brucella infections in odontocetes". Clinical and Vaccine Immunology. 16 (6): 906-15. doi:10.1128/CVI. ... LPSN "Brucella ceti" at the Encyclopedia of Life NOAA informative brochure Type strain of Brucella ceti at BacDive - the ... Brucella ceti is a gram negative bacterial pathogen of the Brucellaceae family that causes brucellosis in cetaceans. Brucella ... and Brucella pinnipedialis sp. nov. for Brucella strains with cetaceans and seals as their preferred hosts". International ...
Brucella abortus
Dorneles, EM; Sriranganathan, N; Lage, AP (8 July 2015). "Recent advances in Brucella abortus vaccines". Veterinary Research. ... Brucella has twelve different kinds of species, one being Brucella abortus. Some of the other species are known as B. ... "Humans and Brucella Species". "Brucellosis: Brucella Abortus" (PDF). Kaden, R.; Ferrari, S.; Jinnerot, T.; Lindberg, M.; Wahab ... Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The ...
Brucella canis
PCR assays have been proven beneficial when differentiating between Brucella strains and vaccine strains. Mantur BG, Amarnath ... Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella ... rather than phenol-water like smooth forms of Brucella are known to be. Colonies of Brucella can typically start to be seen ... Brucella canis can be found in both pets and wild animals and lasts the lifespan of the animal it has affected. B. canis has ...
List of laboratory biosecurity incidents
ISBN 978-0-10-295322-0. "Canadian-made Ebola vaccine used after German lab accident". cbc.ca. 2009-03-20. Retrieved 2009-03-20 ... Pappas, Georgios (2022-11-14). "The Lanzhou Brucella Leak: The Largest Laboratory Accident in the History of Infectious ... Shim, Elizabeth (2020-12-04). "Brucellosis cases in China exceed 10,000 after vaccine factory accident". UPI. Retrieved 2022-11 ... Song, Langui; Gao, Jiangmei; Wu, Zhongdao (April 2021). "Laboratory-acquired infections with Brucella bacteria in China". ...
Alpha-D-phosphohexomutase superfamily
Pei J, Ficht TA (January 2004). "Brucella abortus rough mutants are cytopathic for macrophages in culture". Infection and ... mutant as a new live rough-phenotype vaccine". Infection and Immunity. 71 (11): 6264-9. doi:10.1128/iai.71.11.6264-6269.2003. ... Ugalde JE, Czibener C, Feldman MF, Ugalde RA (October 2000). "Identification and characterization of the Brucella abortus ... Ugalde JE, Comerci DJ, Leguizamón MS, Ugalde RA (November 2003). "Evaluation of Brucella abortus phosphoglucomutase (pgm) ...
Rakesh Bhatnagar
He helped develop a genetically engineered vaccine against anthrax. He is an elected fellow of several major Indian science ... His research group has initiated research in other important infectious disease systems like Mycobacterium, Brucella; aiming to ... His team has also developed a DNA vaccine against Rabies. ... Recombinant Vaccine Development, and Programmed Cell Death in ...
VIOLIN vaccine database
Vaxign has been tested in different pathogen models, including uropathogenic E. coli and Brucella spp. VIOLIN also maintains ... VIOLIN currently contains over 3,000 vaccines or vaccine candidates for over 190 pathogens. The vaccine information in the ... Different types of information is curated, including vaccine name, license status, antigens used, vaccine adjuvants, vaccine ... All vaccine information in the VIOLIN vaccine database is supported by quoted references. The data generated by a curator is ...
Brucellosis vaccine
Brucella+vaccine at the US National Library of Medicine Medical Subject Headings (MeSH) Marta A. Guerra; Barun K. De. " ... Brucellosis vaccine is a vaccine for cattle, sheep and goats used against brucellosis. It is an attenuated vaccine based on a ... Animal vaccines, All stub articles, Vaccine stubs). ... there is no vaccine available for humans. Ko J, Splitter GA ( ... Drugs that are a vaccine, All articles with unsourced statements, Articles with unsourced statements from March 2021, ...
Brucellosis
Currently, all cattle of ages 3-8 months must receive the Brucella abortus strain 19 vaccine. Australia is free of cattle ... Brucella species survive well in aerosols and resist drying. Brucella and all other remaining biological weapons in the U.S. ... Dairy herds in the U.S. are tested at least once a year to be certified brucellosis-free with the Brucella milk ring test. Cows ... An animal vaccine is available that uses modified live bacteria. The World Organisation for Animal Health Manual of Diagnostic ...
Owais Mohammad
"Escheriosomes entrapped DNA vaccine co-expressing Cu-Zn superoxide dismutase and IL-18 confers protection against Brucella ... Vaccine. 2012, 6;30(48):6851-8. doi: 10.1016/j.vaccine.2012.09.010. Ansari MA, Zubair S, Mahmood A, Gupta P, Khan AA, Gupta UD ... Vaccine. 2006, 13;24(7):948-56. doi: 10.1016/j.vaccine.2012.09.010. Chauhan A, Zubair S, Tufail S, Sherwani A, Sajid M, Raman ... Vaccine. 2011, 24;29(29-30):4720-7. doi: 10.1016/j.vaccine.2011.04.088. Mallick AI, Singha H, Chaudhuri P, Nadeem A, Khan SA, ...
Interleukin 15
A Brucella DNA vaccine containing IL-15 gene enhanced the CD8+ T cell immune response in mice. IL-15 was needed for CD4+ T cell ... "An IL-15 adjuvant enhances the efficacy of a combined DNA vaccine against Brucella by increasing the CD8+ cytotoxic T cell ... doi:10.1016/j.vaccine.2009.12.076. PMID 20064480. Hock K, Laengle J, Kuznetsova I, Egorov A, Hegedus B, Dome B, Wekerle T, ... Preclinical results of NDV-modified tumor vaccine showed promise by controlling melanoma tumor growth in mice. A recombinant ...
Tularemia
Sub-unit vaccine candidates, such as killed-whole cell vaccines, are also under investigation, however research has not reached ... Cross reactivity with Brucella can confuse interpretation of the results, so diagnosis should not rely only on serology. ... approved vaccines against tularemia. However, vaccination research and development continues, with live attenuated vaccines ... 2000). Manual of standards for diagnostic tests and vaccines: lists A and B diseases of mammals, birds and bees. Paris, France ...
Iraqi biological weapons program
Some of these materials were used for Iraq's biological weapons research program, while others were used for vaccine ... These materials included anthrax, West Nile virus and botulism, as well as Brucella melitensis, and Clostridium perfringens. ... Approximately 150,000 US troops received the U.S. Food and Drug Administration-licensed anthrax vaccine (BioThrax), and 8,000 ... and new research activities involving Brucella and Crimean-Congo hemorrhagic fever virus. Despite diligent investigations since ...
Charles Pilet
A new type of vaccine Charles Pilet and Marc Bonneau are creating a new type of vaccine from a strain of Brucella abortus made ... An improved vaccine control method The study of several mouse lines showed the sensitivity of some of these lines to Brucella ... This type of vaccine also confirmed the essentially cellular nature of brucella immunity and the passive role of antibodies. A ... which made it possible to propose a new method for controlling brucella vaccines, a method that has since been adopted ...
List of vaccine topics
Negrón, María E.; Kharod, Grishma A.; Bower, William A.; Walke, Henry (2019). "Notes from the Field: Human Brucella abortus ... vaccine Caries vaccine Gonorrhea vaccine Ehrlichiosis vaccine Helicobacter pylori vaccine Leprosy vaccine Lyme disease vaccine ... vaccine Tularemia vaccine Yersinia pestis vaccine Chagas disease vaccine Hookworm vaccine Leishmaniasis vaccine Malaria vaccine ... encephalitis virus vaccine for humans Enterovirus 71 vaccine Epstein-Barr vaccine H5N1 vaccine Hepatitis C vaccine HIV vaccine ...
Azoximer bromide
... displayed ability to enhance immune responses to the live brucellosis vaccine, Brucella abortus strain 82-PS ( ... Immunopotentiation of live brucellosis vaccine by adjuvants. Vaccine 2010;28 Suppl 5:F17-22. Toptygina A, Semikina E, Alioshkin ... All vaccines of the Grippol family have two common features: firstly, they contain a reduced dose of antigens, and secondly, ... Several Grippol vaccines have been developed and approved based on a single technological platform that implements the ...
Julius Youngner
Offit, Paul A. (2007-09-01). The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis. Yale ... antitumor processes of Brucella, and numerous contributions to cold adapted influenza virus. Youngner met and married his first ... The Salk vaccine is based upon formalin inactivated wild type virus. The key to effective inactivation depended upon a color ... Applying this method to a single kidney "could produce enough raw material for 6000 shots of polio vaccine." This advance in ...
Brucella
... at Texas A&M University and her team claim to be close to creating a human vaccine. It would primarily be used to immunize ... Brucella abortus, Brucella canis, Brucella neotomae, Brucella ovis, and Brucella suis are all synonyms of Brucella melitensis. ... Brucella abortus A13334, 3,401 ORFs Brucella canis ATCC 23365, 3,408 ORFs Brucella melitensis 16M, 3,279 ORFs Brucella microti ... 3,193 ORFs Brucella pinnipedialis B2/94, 3,505 ORFs Brucella suis 1330, 3,408 ORFs Genome data for these and other Brucella ...
Brucella suis
The Brucella abortus (rough LPS Brucella) vaccine, developed for bovine brucellosis and licensed by the USDA Animal Plant ... Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis ... of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella ... Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic ...
ATC code J07
J07BX01 Smallpox vaccines J07BX02 Ebola vaccines J07BX03 COVID-19 vaccines J07BX04 Dengue virus vaccines J07CA01 Diphtheria- ... J07AC01 Anthrax antigen J07AD01 Brucella antigen J07AE01 Cholera, inactivated, whole cell J07AE02 Cholera, live attenuated ... ATC code J07 Vaccines is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of ... C Empty group Vaccines for veterinary use are in the ATCvet group QI. "ATC (Anatomical Therapeutic Chemical Classification ...
List of MeSH codes (D20)
... anthrax vaccines MeSH D20.215.894.135.134 - brucella vaccine MeSH D20.215.894.135.225 - cholera vaccines MeSH D20.215.894.135. ... hepatitis a vaccines MeSH D20.215.894.899.955.400 - hepatitis b vaccines MeSH D20.215.894.899.970 - yellow fever vaccine MeSH ... measles vaccine MeSH D20.215.894.899.404.500 - measles-mumps-rubella vaccine MeSH D20.215.894.899.488 - mumps vaccine MeSH ... rubella vaccine MeSH D20.215.894.899.779.500 - measles-mumps-rubella vaccine MeSH D20.215.894.899.790 - saids vaccines MeSH ...
List of infectious diseases
... oral adenovirus type 4 and type 7 vaccine, in U.S. Military recruits". Vaccine. 31 (28): 2963-2971. doi:10.1016/j.vaccine. ... Human Brucella abortus RB51 Infections Caused by Consumption of Unpasteurized Domestic Dairy Products - United States, 2017- ... "MERS vaccine shows promise in clinical trial, say researchers". Archived from the original on 2020-05-03. "Developing a vaccine ... doi:10.1016/j.vaccine.2012.10.003. PMID 23072894. "Collaboration to develop the world's first prophylactic gonorrhoea vaccine ...
Biosafety level
... several species of Brucella, chikungunya, yellow fever virus, West Nile virus, Yersinia pestis, and SARS-CoV-2. Biosafety level ... aerosol-transmitted within the laboratory and cause severe to fatal disease in humans for which there are no available vaccines ...
Epigenetics
... and Brucella. In Alphaproteobacteria, methylation of adenine regulates the cell cycle and couples gene transcription to DNA ... the bacterium to randomly change its characteristics into six alternative states that could pave the way to improved vaccines. ...
PPIB
Aside from these bacteria, PPIB has been identified in Brucella abortus, Mycobacterium tuberculosis, Bacillus subtilis and ... recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes which could be used as cancer vaccines, and in fact ... "Intracellularly Induced Cyclophilins Play an Important Role in Stress Adaptation and Virulence of Brucella abortus". Infection ...
Notifiable diseases in the United Kingdom
... wild or vaccine types) Rabies virus (classical rabies and rabies-related lyssaviruses) Rickettsia spp Rift Valley fever virus ... Bordetella pertussis Borrelia spp Brucella spp Burkholderia mallei Burkholderia pseudomallei Campylobacter spp Chikungunya ...
Myocarditis
... and pericarditis can be a rare side effect of some vaccines like the smallpox vaccine. The Covid-19 mRNA vaccines ... Brucella, Corynebacterium diphtheriae, Neisseria gonorrhoeae, Haemophilus influenzae, Actinomyces, Tropheryma whipplei, Vibrio ... "Coronavirus (COVID-19) vaccines side effects and safety". nhs.uk. Retrieved 30 October 2022. "Risk of Myocarditis Following ... The FDA and European Medicines Agency estimates the risk of myocarditis after the Covid-19 vaccine as 1 case per 100,000 of ...
Joseph Vinetz
He also used systems immunology to study the serial kinetics of the antibody response against the complete brucella melitensis ... vivax vaccine candidates. He studies endemic malaria in the context of the Peruvian Amazon region of Iquitos and discussed the ... and transmission-blocking vaccine development, including, in collaboration with Stephen Mayfield at UCSD, the use of ... with a key focus on vaccine development. Vinetz found cases of severe leptospirosis in relation to environmental exposure and ...
Biological warfare
Hassani M, Patel MC, Pirofski LA (April 2004). "Vaccines for the prevention of diseases caused by potential bioweapons". ... Agents considered for weaponization, or known to be weaponized, include bacteria such as Bacillus anthracis, Brucella spp., ... Would demonstrate how to render a vaccine ineffective; Would confer resistance to therapeutically useful antibiotics or ... non-availability of vaccines and availability of an effective and efficient delivery system. Stability of the weaponized agent ...
Biopreparat
Brucella sp. (the causative agent of Brucellosis) Smallpox virus Venezuelan equine encephalitis virus Marburg virus Machupo ... operating in 15 different cities and had control of domestic production of vaccines, antibiotics and other essential medicines ...
Campylobacter fetus
The ovine Cff vaccine has likewise been found ineffective in preventing future infections in ewes given that it does not ... of the deceased fetus causes necrosis of the placenta and placental lesions are not easily distinguished from Brucella abortus ... As vaccines are typically not efficient in preventing future spread, infected bulls are often culled. Human infections may be ... Vaccines can be used to reduce the occurrence of campylobacteriosis but will not eradicate infections. For example, vaccination ...
Emerging infectious disease
"A brief history of vaccines and how they changed the world". World Economic Forum. Retrieved 2020-04-30. "Creating a world in ... Brucella species (brucellosis) Burkholderia pseudomallei (melioidosis) Burkholderia mallei (glanders) Coxiella burnetii (Q ... The proposed interventions were based on the following: the U.S. public health system, research and training, vaccine and drug ... such as vaccine-derived poliovirus The 1992 IOM report distinguished 6 factors contributing to emergence of new diseases ( ...
Karl Friedrich Meyer
Subsequently, a vaccine for horses was developed. And it turned out that the isolation of the virus by Meyer led to the ... He suggested classing the various species of bacteria into one family (genus), formally named Brucella, to honor the discoverer ... During the years of World War II a vaccine against yellow fever was used in the Armed Forces that produced (unexpectedly) ... It was actually manufactured at the Hooper when the Army needed vaccines to protect the troops in Vietnam (one endemic area ...
Antimicrobial resistance
Microorganisms usually do not develop resistance to vaccines because vaccines reduce the spread of the infection and target the ... "Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective". Scientific Reports. ... Development and testing of more effective vaccines is underway. Two registrational trials have evaluated vaccine candidates in ... Vaccine recipients who developed S. aureus infection were five times more likely to die than control recipients who developed S ...
List of University of Edinburgh people
... discoverer of Brucella Min Chueh Chang, inventor of Combined oral contraceptive pill and pioneer in IVF, Lasker Award winner in ... developer of the HPV vaccine Dame Anne Glover FRS, Chief Scientific Adviser to the President of the European Commission from ...
List of veterinarians
Camille Guérin (1872-1961) - developed a vaccine for tuberculosis James Hallen (1829-1901) - British veterinarian who served as ... Danish veterinarian who discovered Brucella abortus Denis Barberet (1714-1770) - French bibliographer and author Harold William ...
Hepatitis
If the vaccine is for hepatitis A only, two doses are given 6-18 months apart depending on the manufacturer. If the vaccine is ... brucella species and campylobacter species. Chronic or granulomatous hepatitis is seen with infection from mycobacteria species ... There is also a combination formulation that includes both hepatitis A and B vaccines. There are currently no vaccines ... People in these groups who are not already immune can receive the hepatitis A vaccine. Those at high risk and in need of ...
Browsing by Subject "Brucella Vaccine"
Report of the WHO Informal Meeting on Oral/Conjunctival Brucellosis Strain 2 Vaccine, Nouzilly, France, 8-9 February 1989 ... The Development of new/improved brucellosis vaccines : report of a WHO meeting, Geneva, Switzerland, 11-12 December 1997 ... Report of the FAO/WHO Informal Meeting on Oral/Conjunctival Brucellosis Vaccine, Rome, Italy, 6-7 September 1988 ... Report of WHO Working Group Meeting on Oral/Conjunctival Brucellosis Strain 2 Vaccine, Rome, 2-4 October 1991 ...
Biosafety of parenteral Brucella abortus RB51 vaccine in bison calves
Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x ... Before their use, however, vaccine safety and efficacy must be demonstrated. ... Biosafety of parenteral Brucella abortus RB51 vaccine in bison calves. Journal of Wildlife Management ... Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x ...
Transboundary Spread of Brucella canis through Import of Infected Dogs, the Netherlands, November 2016-December 2018 - Volume...
In: Manual of diagnostic tests and vaccines for terrestrial animals. 2018 [cited 2020 Mar 25]. https://www.oie.int/fileadmin/ ... Lucero NE, Corazza R, Almuzara MN, Reynes E, Escobar GI, Boeri E, et al. Human Brucella canis outbreak linked to infection in ... Egloff S, Schneeberger M, Gobeli S, Krudewig C, Schmitt S, Reichler IM, et al. Brucella canis infection in a young dog with ... Maio E, Begeman L, Bisselink Y, van Tulden P, Wiersma L, Hiemstra S, et al. Identification and typing of Brucella spp. in ...
Browsing by Subject
Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine...
Brucella abortus S19 vaccine is a stable attenuated smooth strain, globally used as calfhood vaccine for the prevention of ... Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine ... Four vaccine doses of which the first dose consisted of full dose (40 × 109 CFU/dose) and the other three were 1/10th, 1/20th, ... Each vaccine dose was administered to 13 cattle calves of 4-5 months of age maintained in separate groups. The blood samples ...
Summary of Notifiable Diseases --- United States, 2005
Brucella abortus strain RB51: a new brucellosis vaccine for cattle. Compendium 1997;19:766--74. ... The effectiveness of the mumps component of the MMR vaccine: a case control study. Vaccine 2005;23:4070--4. ... Brucellosis (Brucella melitensis, abortus, suis, and canis). Atlanta, GA: US Department of Health and Human Services, CDC; 2005 ... Vaccine-derived polioviruses and the endgame strategy for global polio eradication. Annu Rev Microbiol 2005; 59:587--635. Q ...
Darrell Bayles : USDA ARS
Genome report-a genome sequence analysis of the RB51 strain of Brucella abortus in the context of its vaccine properties. G3, ... paratuberculois protein cocktail vaccines in a mouse model - (Proceedings) Barnhill, A.E., Bannantine, J.P., Chang, Y., Osman, ... paratuberculosis protein cocktail vaccines in a mouse model - (Abstract Only) Barnhill, A.E., Bannantine, J.P., Chang, Y., ... Salmonella DIVA vaccine reduces disease, colonization and shedding due to virulent S. Typhimurium infection in swine - (Peer ...
WHO EMRO | Seroprevalence of Brucella species among women with miscarriage in Jordan | Volume 17, issue 11 | EMHJ volume 17,...
Seroprevalence of Brucella species among women with miscarriage in Jordan ... A review of the use of B. melitensis Rev 1 vaccine in adult sheep and goats. Preventive Veterinary Medicine, 1997, 31:275-283. ... In animals, Brucella spp. is an established major cause of miscarriage and serious economic loss to dairy and small ruminant ... The seroprevalence of Brucella spp. was reported as 8% among high risk people in Jordan [16]. According to Thrusfield [18], the ...
Publications at this Location : USDA ARS
HOST SPECIES DIFFERENCES IN RESPONSES TO BRUCELLA OR MYCOBACTERIUM VACCINES (Abstract Only) (4-Dec-05) ... Report of the Vaccine Working Group. Enhancing Brucellosis Vaccines, Vaccine Delivery, and Surveillance Diagnostics for Elk and ... DNA VACCINES AGAINST TUBERCULOSIS (Book / Chapter) (8-Dec-05) THE MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS GENOME AND ... SUSCEPTIBILITY OF BRUCELLA TO MACROLIDES: ANALYSES OF THE 23S RDNA, L4 AND L22 (Abstract Only) (22-Sep-05) ...
HAN Archive - 00417 | Health Alert Network (HAN)
Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. ... Notes from the Field: Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise ... This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U. ... Milk samples from the dairy tested positive for Brucella strain RB51. People who consumed raw milk or raw milk products from ...
سامانه نشر مجلات علمی دانشگاه تهران
FL - Department of Agriculture & Consumer Services - Animal Disease Control | Animal Legal & Historical Center
1) "Approved brucella vaccine" means a Brucella abortus immunization product approved and licensed by the United States ... vaccines, live microorganisms, killed microorganisms, and the antigenic or immunizing components of microorganisms intended for ... vaccine, or other therapeutic or prophylactic agent. ... e) Fowl laryngotracheitis vaccine;. (f) Anthrax spore vaccine; ...
NIOSHTIC-2 Search Results - Full View
... had accidentally self-injected vaccines containing live Brucella organisms. Inadvertent self-injection of vaccines, ... In a 1995 survey of 701 veterinarians, accidental self-injection of rabies virus vaccine was reported by 27% of respondents; ... the most commonly reported needlestick injury is inadvertent injection of a vaccine. ...
HAN Archive - 00417 | Health Alert Network (HAN)
Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. ... Notes from the Field: Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise ... This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U. ... Milk samples from the dairy tested positive for Brucella strain RB51. People who consumed raw milk or raw milk products from ...
Laboratory Exposures to Brucellae and Implications for Bioterrorism - Volume 11, Number 8-August 2005 - Emerging Infectious...
... and laboratories that manufactured Brucella vaccines has also been documented (21,22). A laboratory technician at the Centers ... Brucellae are considered class 3 organisms. CDC has strongly recommended that live Brucella cultures and suspicious organisms ... and administration of influenza vaccine should be strongly recommended to all Brucella-exposed persons. If symptoms develop, ... Brucella canis. A cause of undulant fever. Am J Med. 1975;59:424-6. DOIPubMedGoogle Scholar ...
View source for Immunology Ontologies and Their Applications in Processing Clinical Data - NCBO Wiki
... and its treatment of Brucella-host interaction. 16:30 Oliver He (University of Michigan) ::Contributions of the Vaccine ... VO is a community-based biomedical ontology in the domain of vaccine and vaccination. We will introduce the top level of VO, ... 10:45 Break 11:15 Oliver He (University of Michigan) ::How Flow Cytometry can be used in Vaccine Research :::To better ... Vaccine Ontology (Oliver He) :AO Allergy Ontology (Alex C. Yu) :ND Neurological Disease Ontology (Alexander Diehl) ---- == ...
Scientists Discover How to Disarm Superbug Bacterias
Fever-inducing Brucella isnt very contagious, and cases are rare, but its also very hard to treat and there isnt a vaccine. ... In other words Brucella is a superbug, but you dont have to worry about an experiment getting out of hand. The researchers ... In a study published in Chemistry & Biology, scientists describe how they managed to block Brucella from bonding with a host. ... we could effectively eliminate the virulence of Brucella regardless of whether or not a particular strain is drug resistant. So ...
Funded Research - PWD Foundation, Inc.
List of Publications from OWH Supported Studies | FDA
CDC says it improperly sent dangerous pathogens in five incidents in past decade - The Washington Post
CDC Investigation of Brucella abortus RB51 Infection Linked to Pennsylvania Dairy
Lyme Disease Vaccine Shows Antibodies 6 Months after Completion. FDA Expands Ibrexafungerp Approval for Reduction of Recurrent ... A case of Brucella abortus RB51 infection in 2018 was traced back to a Pennsylvania dairy, raising concerns about the risk of ... The CDC launched an investigation of exposure to the Brucella abortus RB51 strain last year. No other cases of brucellosis were ... The cow, which had received the vaccine in 2011 and was purchased by the dairy in 2016, was taken out of production. Subsequent ...
Publication year rev: 7984-2016 / Subject: 3 selected / Subject term: Mirounga - PubAg Search Results
Brucella Remove constraint Subject: Brucella Subject Phocine morbillivirus Remove constraint Subject: Phocine morbillivirus ... vaccine adjuvants; Toll-like receptor 1. Abstract:. ... Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key ... Mirounga; endangered species; methicillin-resistant Staphylococcus aureus; marine mammals; population dynamics; Brucella; risk ...
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About Brucella. RB51 is a weakened strain of Brucella abortus bacteria used to vaccinate young female cattle. Intensive ... The bovine vaccine reduces the risk of people contracting brucellosis from infected cows. However, in rare cases, vaccinated ... The Brucella RB51 strain is resistant to some antibiotics that would normally be used to prevent or treat brucellosis. ... While Brucella can cause anyone to become sick, women may suffer miscarriage and other pregnancy complications making it ...
Seeking a niche<...
keywords = "Animals, Bacterial Proteins, Bacterial Vaccines, Brucella, Host Factor 1 Protein, Intracellular Fluid, Macrophages ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ... Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the ...
Introduction
Brucella abortus. Vaccine strain RB51. 05-07-2003. Burkholderia pseudomallei. Bp82 (a Δ. purM. mutant of strain 1026b). 04-14- ... Vaccine candidate strain ΔNSs-ΔNSm-ZH501. 03-12-2012. SARS-Coronavirus. NATtrol™ treated SARS-CoV molecular controls. 02-08- ... Bacillus anthracis, Brucella. spp., Mycobacterium tuberculosis, Salmonella typhi, Shigella dysenteriae. 4. An organism that ... LVS (live vaccine strain; includes NDBR 101 lots, TSI-GSD lots, and ATCC 29684). 02-27-2003. ...
JournalTOCs
Prevention Guidelines Titles
Current Trends Rabies Vaccine, Adsorbed: A New Rabies Vaccine for Use in Humans; 1988:04:15. Agent Summary Statement for Human ... Human Exposure to Brucella abortus Strain RB51 -- Kansas, 1997; 1998:03:13. Administration of Zidovudine During Late Pregnancy ... Decreased Antibody Response to Influenza Vaccine Among Nursing-Home Residents Who Received Recalled Vaccine -- New York, 1996; ... Rabies Postexposure Prophylaxis with Human Diploid Cell Rabies Vaccine: Lower Neutralizing Antibody Titers with Wyeth Vaccine; ...
InfectionRB51MelitensisLive-attenuatedAbortus vaccineCanisPathogenAntigensIntracellularExposureAbstract2018BacterialVaccinationSpeciesCattleICAREfficacyInadvertentHumansBacteriaVacunaPathogensImmunityInfections1991Terrestrial animalsOrganismsCandidateImmune responsesProteinInvestigation2016SubunitOntologyBovine brucellosisImmunizationPregnant women10.1016InteractionsClinical trialsLaboratoryCampylobacterRoughHostsCandidates
Infection9
- ABSTRACT Results differ as to whether Brucella infection during pregnancy increases a woman's risk of miscarriage. (who.int)
- Brucella abortus vaccine strain RB51 infection and exposures associated with raw milk consumption - Wise County, Texas, 2017. (cdc.gov)
- Canine infection by Brucella spp. (pwdfoundation.org)
- A case of Brucella abortus RB51 infection in 2018 was traced back to a Pennsylvania dairy, raising concerns about the risk of infections from drinking raw milk. (contagionlive.com)
- In this study, patho-physiological response to Brucella abortus S19Δper infection in BALB/c mice was assessed in comparison to its parent strain, B. abortus S19 and virulent strain, B. abortus 544. (who.int)
- The current vaccine strain, RB51, is able to induce protection from natural brucellosis infection in cattle but not in wildlife. (uwyo.edu)
- 2015. Host Response to Brucella Infection : Review and Future perspective. (unair.ac.id)
- These studies are principally targeted on the understanding of the response to infection by the host and elucidating the correlates of protective immunity elicited by the encapsulated and non-encapsulated vaccines. (tamu.edu)
- Brucellosis is a disease caused by infection with bacteria of the genus Brucella. (atlasofscience.org)
RB5117
- Exposure to the Brucella abortus RB51 culture for confirmation ( 1 ). (cdc.gov)
- These cases abortus strain RB51 vaccine (RB51) to cattle 3 weeks before highlighted the lack of awareness of the unique challenges in symptom onset. (cdc.gov)
- OPHD and cians unfamiliar with management of human RB51 Brucella the local health jurisdiction provided RB51-specific treatment infections and exposures. (cdc.gov)
- Adverse events in humans ity in humans, he had not sought the recommended postexpo- associated with accidental exposure to the livestock brucellosis vaccine RB51. (cdc.gov)
- Twenty-seven female bison (Bison bison) calves (approx 5 months old) were vaccinated with Brucella abortus Strain RB51 (1.5 x 1010 colony forming units [CFU], subcutaneously) as part of routine management. (usgs.gov)
- The New York State Department of Health and Pennsylvania Department of Health are investigating Brucella RB51 exposures that may be connected to consuming raw (unpasteurized) milk from Miller's Biodiversity Farm in Quarryville, Pennsylvania. (cdc.gov)
- This investigation is associated with the third known case of brucellosis from Brucella RB51 due to raw milk acquired in the U.S., since August 2017. (cdc.gov)
- Milk samples from the dairy tested positive for Brucella strain RB51. (cdc.gov)
- Brucella strain RB51 is a live-attenuated cattle vaccine strain, which can be shed in milk and can cause infections in humans. (cdc.gov)
- However, there have now been three documented cases of brucellosis caused by Brucella abortus RB51 linked to consumption of unpasteurized milk since 2017. (contagionlive.com)
- The CDC launched an investigation of exposure to the Brucella abortus RB51 strain last year. (contagionlive.com)
- We want to prevent infections by making sure people understand the risk of serious infections when consuming unpasteurized milk," Gruber said "We will also continue to look for any new Brucella abortus RB51 infections. (contagionlive.com)
- Now the CDC have warned anyone who drank the product from a company called Udder Milk that they may too have been infected with the bacteria Brucella abortus RB51. (newfoodmagazine.com)
- CDC confirmed her illness was Brucella RB51 in late October. (newfoodmagazine.com)
- The Brucella RB51 strain is resistant to some antibiotics that would normally be used to prevent or treat brucellosis. (newfoodmagazine.com)
- RB51 is a weakened strain of Brucella abortus bacteria used to vaccinate young female cattle. (newfoodmagazine.com)
- The heat of pasteurisation kills RB51, other types of Brucella, and a variety of other disease-causing bacteria. (newfoodmagazine.com)
Melitensis3
- Different fractions of Brucella (B) abortus or Brucella melitensis have been used as antigens for the detection of anti-Brucella antibodies in goat sera, being their accomplishment cumbersome and time consuming. (gob.ar)
- Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. (gob.ar)
- 2010. Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens. (unair.ac.id)
Live-attenuated2
- The case, detailed in a recent Morbidity and Mortality Weekly Report , involved a New York patient who contracted brucellosis from the live attenuated vaccine strain of B. abortus used to prevent brucellosis in cattle. (contagionlive.com)
- Nevertheless, we present a strategy towards the production of low-cost "live-attenuated multivalent vaccine factories" with the ability to express glycoconjugates in poultry. (biomedcentral.com)
Abortus vaccine1
- Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats. (bvsalud.org)
Canis2
Pathogen5
- We have developed VO-based natural language processing (NLP) approaches to retrieve and analyze vaccine-specific interaction networks of host or pathogen genes. (stanford.edu)
- and (3) VO-based literature mining provided better performance than the MeSH-based PubMed approach in retrieving the interactions between vaccines and genes from Brucella (a bacterial pathogen). (stanford.edu)
- His group has also developed and applied ontology-based literature mining tools to study biological pathways with an emphasis on vaccine-associated gene interaction networks among host and pathogen genes. (stanford.edu)
- Glycoconjugate vaccines, which consist of an immunogenic protein covalently coupled to glycan antigens of the targeted pathogen, have a proven track record in human vaccinology, but have yet to be used for livestock due to prohibitively high manufacturing costs. (biomedcentral.com)
- 3) Vaccine informatics, host-pathogen interactions, and vaccine/drug design and safety analysis. (hegroup.org)
Antigens2
- VO also represents all types of vaccine components (e.g., vaccine antigens and adjuvants) and vaccine preparations. (stanford.edu)
- As described below, we applied our own reverse vaccinology and mechine learning methods to predict COVID-19 vaccine antigens . (hegroup.org)
Intracellular1
- Analysis of Brucella bacA mutants, on the other hand, reveal very striking parallels between the strategies employed by the rhizobia to establish and maintain protracted intracellular residence in their plant host and those used by the brucellae during their long-term survival in the phagosomal compartment of host macrophages. (elsevier.com)
Exposure2
- Discovery of a laboratory exposure to brucellae should prompt an exhaustive investigation of the event and its circumstances, definition of the population at risk, enforcement of safe laboratory practices, and antimicrobial drug prophylaxis for exposed persons. (cdc.gov)
- When the exposure of the vaccine industry's abuses and failures finally happens, will we treat it with the same ho-hum indifference that we show for the ever-growing list of Pharma drug crimes? (badlymeattitude.com)
Abstract1
- ABSTRACT: The Vaccine Ontology (VO, http://www.violinet.org/vaccineontology) is a community-based biomedical ontology in the domain of vaccine and vaccination. (stanford.edu)
20182
- OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2018. (phylaxialabor.hu)
- and Vaccines for Terrestrial Animals 2018. (phylaxialabor.hu)
Bacterial4
- Seeded media harbor considerable amounts of viable Brucella organisms, and routine bacteriologic procedures such as preparing, centrifuging, and vigorous agitation (vortexing) of bacterial suspensions, performing subcultures and biochemical testing, and particularly the catalase test, may create dangerous aerosols and the potential for accidental spillage ( 14 ). (cdc.gov)
- These vaccines have been developed against infections of various bacterial, viral, and parasitic pathogens as well as cancers in over 20 animal species. (stanford.edu)
- A bacterial vaccine for the prevention of brucellosis in man and animal. (bvsalud.org)
- To overcome this, we use Protein Glycan Coupling Technology (PGCT), which enables the production of glycoconjugates in bacterial cells at considerably reduced costs, to generate a candidate glycan-based live vaccine intended to simultaneously protect against Campylobacter jejuni , avian pathogenic Escherichia coli (APEC) and Clostridium perfringens . (biomedcentral.com)
Vaccination3
- The blood samples were collected on 0 to 240 days post- vaccination (DPV) at the intervals of 0, 14, 28, 45, 60, 90, 150, 180 and 240 for assessment of vaccine -induced innate, humoral and cell -mediated immune responses . (bvsalud.org)
- Despite section 7, a vaccine to be administered as part of a vaccination operation under the Public Health Act (chapter S-2.2) may be sold without prescription to a nurse for professional use. (gouv.qc.ca)
- The Vaccine Ontology (VO) has become a community effort for standard representation of vaccines, vaccine components, vaccination, and host responses to vaccines. (hegroup.org)
Species2
- https://doi.org/10.3201/eid1707.110222 sidered atypical Brucella species similar to B. microti and 10. (cdc.gov)
- Most of Brucella species are capable of infecting humans, and they are all considered zoonotic since different animals are their preferential hosts. (atlasofscience.org)
Cattle4
- Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India. (bvsalud.org)
- Various agencies demonstrated different doses for vaccinating cattle and buffalo calves leading to ambiguity in selecting a suitable immune vaccine dose . (bvsalud.org)
- Each vaccine dose was administered to 13 cattle calves of 4-5 months of age maintained in separate groups. (bvsalud.org)
- Brucella abortus is the etiological agent of brucellosis in cattle and elk and is known to cause abortion, sterility and decreased milk production. (uwyo.edu)
ICAR1
- Hester has signed the agreement towards receiving the indigenously developed technology from ICAR-IVRI (Indian Council of Agriculture Research - Indian Veterinary Research Institute), for developing the Brucella Abortus S19 Delta Per vaccine. (agrinnovateindia.co.in)
Efficacy2
Inadvertent3
- the most commonly reported needlestick injury is inadvertent injection of a vaccine. (cdc.gov)
- Inadvertent self-injection of vaccines, antimicrobials, and anesthetic agents by veterinary personnel may result in adverse events that range from local irritation to serious systemic reactions. (cdc.gov)
- Inadvertent exposures to brucellae in the clinical laboratory indicate a widespread lack of preparedness to cope with eventual biologic threats involving use of the organism. (cdc.gov)
Humans2
- Several biologic characteristics make brucellae easily transmissible within the close confinement of the clinical microbiology laboratory, including the facts that the infecting dose for humans is low, and the organism may enter the body in many ways relevant to laboratory practices (e.g., through the respiratory mucosa, conjunctivae, gastrointestinal tract, or abraded skin) ( 1 , 2 ). (cdc.gov)
- Atypical Brucella lesions in humans, an outbreak of glanders in Bahrain suggests multiple wild mammals, amphibians, and fish range from lo- introduction events. (cdc.gov)
Bacteria1
- The researchers found that bacteria like Brucella need the protein VirB8 to latch on. (gizmodo.com)
Vacuna3
- Elaboraci'on y normalizaci'on de la vacuna brucella abortus, cepa 19. (who.int)
- Vacuna bacteriana para la prevención de la brucelosis en humanos y animales. (bvsalud.org)
- La vacuna de Brucella abortus se utiliza para la inmunización del ganado bovino, ovino y caprino. (bvsalud.org)
Pathogens1
- We generated a candidate glycan-based multivalent live vaccine with the potential to induce protection against key avian and zoonotic pathogens ( C. jejuni , APEC, C. perfringens ). (biomedcentral.com)
Immunity1
- This study was designed to evaluate a protein from B. abortus that may potentially make an excellent candidate for induction of protective immunity and a possible subunit vaccine candidate. (uwyo.edu)
Infections4
- In pregnant patients, Brucella infections can be associated with miscarriage. (cdc.gov)
- Conclusion: All the data suggested that the mAb (N06) can be used as diagnostic reagents for PRRSV detection, while the recognized linear epitope can be useful in epitope-based vaccines development, which is helpful for the control of local PRRSV infections in swine. (bvsalud.org)
- Low-cost vaccines that can be combined to protect poultry against multiple infections are a current global imperative. (biomedcentral.com)
- dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening disease that is frequently fatal, for which there are no vaccines or treatments, or a related agent with unknown risk of transmission. (absa.org)
19911
- 1991. Determination of Brucella Immunoglobulin G Agglutinating Antibody Titer with Dithiothretol. (unair.ac.id)
Terrestrial animals1
- In: Manual of diagnostic tests and vaccines for terrestrial animals. (cdc.gov)
Organisms3
- among large-animal practice respondents, 23% had accidentally self-injected vaccines containing live Brucella organisms. (cdc.gov)
- Brucellae are class 3 organisms and potential agents of bioterrorism. (cdc.gov)
- The concentration of Brucella organisms in the blood ( 11 , 12 ) and synovial fluid ( 13 ) of patients with brucellosis is usually low, and therefore, these clinical specimens probably pose a low risk for contagion for laboratory personnel. (cdc.gov)
Candidate3
- S19Δper, thus could be a safer vaccine candidate as an alternate to the S19 vaccine strain. (who.int)
- The aim of this study was design of a novel multi-epitope vaccine (MEV) candidate against the CHIKV structural proteins using comprehensive immunoinformatics and immune simulation analyses. (bvsalud.org)
- The described characteristics of BLS make this protein an excellent candidate for vaccine development. (conicet.gov.ar)
Immune responses1
- In addition, various vaccine-induced immune responses and protection against specific disorders are being modeled in VO. (stanford.edu)
Protein1
- But if scientists can figure out how to inhibit the protein in the human body, we could effectively eliminate the virulence of Brucella regardless of whether or not a particular strain is drug resistant. (gizmodo.com)
Investigation1
- The patient reported having investigation of cases and exposures after raw (unpasteurized) sustained a needle stick while administering the Brucella milk consumption in Texas and New Jersey ( 4 , 5 ). (cdc.gov)
20161
- The cow, which had received the vaccine in 2011 and was purchased by the dairy in 2016, was taken out of production. (contagionlive.com)
Subunit1
- Finally, 4 CTL and HTL each while 6 B cell 16-mers were used for designing multiepitope subunit (MSV) and mRNA vaccine joined via suitable linkers. (bvsalud.org)
Ontology3
- The next NCBO Webinar will be presented May 2 by Oliver He from the University of Michigan Medical School on "Vaccine Ontology (VO) and its application in literature mining of vaccine-gene interaction networks" at 10:00am PT, Wednesday, May 2. (stanford.edu)
- Dr. He is also an active developer of the Ontology for Biomedical Investigations (OBI), which is collaboratively developed by over 20 communities, and Dr. He is the representation of the vaccine community. (hegroup.org)
- We have also applied the Vaccine Ontology (VO) and CIDO to model, represent, and analyze COVID-19 vaccines, and are currently developing a COVID-19 vaccine knowledgebase (Cov19VaxKB) . (hegroup.org)
Bovine brucellosis1
- Brucella abortus S19 vaccine is a stable attenuated smooth strain , globally used as calfhood vaccine for the prevention of bovine brucellosis . (bvsalud.org)
Immunization1
- Immunization with strain 19, the first vaccine to be developed and used, is highly reactogenic and not recommended for use in wildlife. (uwyo.edu)
Pregnant women1
- While Brucella can cause anyone to become sick, women may suffer miscarriage and other pregnancy complications making it critical for pregnant women who may have consumed the raw milk from Udder Milk to seek medical care immediately. (newfoodmagazine.com)
10.10161
- https://doi.org/10.1016/j.vaccine.2006.07.046 Full text not available from this repository. (lshtm.ac.uk)
Interactions1
- 2003. Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum, 198(4). (unair.ac.id)
Clinical trials2
- VO represents over 1,000 licensed vaccines and vaccine candidates in clinical trials and in research. (stanford.edu)
- Why in News Recently, India has started phase I/II clinical trials of Covid-19 vaccine - ZyCoV-D, designed and developed by Zydus (a pharmaceutical. (drishtiias.com)
Laboratory2
- When ordering blood cultures to diagnose brucellosis, please advise the laboratory that blood culture may grow Brucella and that appropriate laboratory containment and precautions should be observed. (cdc.gov)
- My laboratory is interested in the development of vaccines against select agents focusing onBrucella spp. (tamu.edu)
Campylobacter1
- The live vaccine failed to significantly reduce Campylobacter colonisation under the conditions tested but was protective against homologous APEC challenge. (biomedcentral.com)
Rough1
- a stable rough strain of Brucella abortus . (cdc.gov)
Hosts1
- Long-term residence of the brucellae in the phagosomal compartment of host macrophages is essential to their ability to produce disease in both natural and experimental hosts. (elsevier.com)
Candidates1
- We have also used these tools to predict COVID-19 vaccine candidates . (hegroup.org)