A species of gram-negative bacteria, primarily infecting SWINE, but it can also infect humans, DOGS, and HARES.
A genus of gram-negative, aerobic bacteria that causes BRUCELLOSIS. Its cells are nonmotile coccobacilli and are animal parasites and pathogens. The bacterium is transmissible to humans through contact with infected dairy products or tissue.
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. Abortion and placentitis are frequently produced in the pregnant animal. Other mammals, including humans, may be infected.
A species of the genus BRUCELLA whose natural hosts are sheep and goats. Other mammals, including humans, may be infected. In general, these organisms tend to be more virulent for laboratory animals than BRUCELLA ABORTUS and may cause fatal infections.
A species of STREPTOCOCCUS isolated from pigs. It is a pathogen of swine but rarely occurs in humans.
A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.
A species of gram-negative, obligately aerobic rods. Motility occurs by peritrichous flagella. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
A species of the genus BRUCELLA which are pathogenic to SHEEP.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A species of gram-negative bacteria infecting DOGS, the natural hosts, and causing canine BRUCELLOSIS. It can also cause a mild infection in humans.
A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.

The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. (1/78)

The pathogen Brucella suis resides and multiplies within a phagocytic vacuole of its host cell, the macrophage. The resulting complex relationship has been investigated by the analysis of the set of genes required for virulence, which we call intramacrophagic virulome. Ten thousand two hundred and seventy-two miniTn5 mutants of B. suis constitutively expressing gfp were screened by fluorescence microscopy for lack of intracellular multiplication in human macrophages. One hundred thirty-one such mutants affected in 59 different genes could be isolated, and a function was ascribed to 53 of them. We identified genes involved in (i) global adaptation to the intracellular environment, (ii) amino acid, and (iii) nucleotide synthesis, (iv) sugar metabolism, (v) oxidoreduction, (vi) nitrogen metabolism, (vii) regulation, (viii) disulphide bond formation, and (ix) lipopolysaccharide biosynthesis. Results led to the conclusion that the replicative compartment of B. suis is poor in nutrients and characterized by low oxygen tension, and that nitrate may be used for anaerobic respiration. Intramacrophagic virulome analysis hence allowed the description of the nature of the replicative vacuole of the pathogen in the macrophage and extended our understanding of the niche in which B. suis resides. We propose calling this specific compartment "brucellosome."  (+info)

Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophages. (2/78)

Brucella species are gram-negative, facultative intracellular bacteria that infect humans and animals. These organisms can survive and replicate within a membrane-bound compartment inside professional and nonprofessional phagocytic cells. Inhibition of phagosome-lysosome fusion has been proposed as a mechanism for intracellular survival in both cell types. However, the molecular mechanisms and the microbial factors involved are poorly understood. Smooth lipopolysaccharide (LPS) of Brucella has been reported to be an important virulence factor, although its precise role in pathogenesis is not yet clear. In this study, we show that the LPS O side chain is involved in inhibition of the early fusion between Brucella suis-containing phagosomes and lysosomes in murine macrophages. In contrast, the phagosomes containing rough mutants, which fail to express the O antigen, rapidly fuse with lysosomes. In addition, we show that rough mutants do not enter host cells by using lipid rafts, contrary to smooth strains. Thus, we propose that the LPS O chain might be a major factor that governs the early behavior of bacteria inside macrophages.  (+info)

Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection. (3/78)

Brucella spp. are intramacrophage pathogens that induce chronic infections in a wide range of mammals, including domestic animals and humans. Therefore, the macrophage response to infection has important consequences for both the survival of phagocytosed bacteria and the further development of host immunity. However, very little is known about the macrophage cell signaling pathways initiated upon infection and the virulence strategy that Brucella use to counteract these responses and secure their survival. In a previous study, we have shown that macrophages activated by SR141716A, a ligand of the cannabinoid receptor CB1, acquired the capacity to control Brucella and observed that the CB1 receptor-triggering engages the microbicidal activity of phagocytes. To analyze the perturbation of cell signaling pathway during macrophage infection by Brucella, we hypothesized that SR141716A provides cell signaling that interferes with the bacterial message leading to inhibition of macrophage functions. As CB1 receptor belongs to the family of G protein-linked receptors, we explored the cAMP signaling pathway. In this study, we show that the CB1 ligand inhibited the bacteria-induced cell signaling. Taking advantage of this result, we then demonstrated that Brucella infection elicited a rapid activation of the cAMP/protein kinase A pathway. This activation resulted in a prolonged phosphorylation of the transcription factor CREB. We finally demonstrate that the activation of the cAMP/protein kinase A pathway is crucial for the survival and establishment of Brucella within macrophages. For the first time in phagocytes, we thus characterized a primordial virulence strategy of Brucella involving the host signaling pathway, a novel point of immune intervention of this virulent pathogen.  (+info)

Epitope mapping of the Brucella melitensis BP26 immunogenic protein: usefulness for diagnosis of sheep brucellosis. (4/78)

Sequencing of bp26, the gene encoding the Brucella sp. immunogenic BP26 periplasmic protein, was performed in the reference strains of Brucella abortus, B. suis, and B. ovis. The three bp26 sequences were almost identical to that published for B. melitensis 16M bp26, and only minor nucleotide substitutions, without modifying the amino acid sequence, were observed between species. The bp26 genes of the seven B. abortus biovar reference strains and B. abortus S19 and RB51 vaccine strains were also sequenced. Again, only minor differences were found. Surprisingly, the bp26 nucleotide sequence for B. abortus S19 was almost identical to that found for B. melitensis 16M and differed from the sequence described previously by others (O. L. Rossetti, A. I. Arese, M. L. Boschiroli, and S. L. Cravero, J. Clin. Microbiol. 34:165-169, 1996) for the same B. abortus strain. The epitope mapping of BP26, performed by using a panel of monoclonal antibodies and recombinant DNA techniques, allowed the identification of an immunodominant region of the protein interesting for the diagnosis of B. melitensis and B. ovis infection in sheep. A recombinant fusion protein containing this region of BP26 reacted indeed, in Western blotting, as the entire recombinant BP26 against sera from B. melitensis- or B. ovis-infected sheep while it avoided false-positive reactions observed with sera from Brucella-free sheep when using the entire recombinant BP26. Thus, use of this recombinant fusion protein instead the entire recombinant BP26 could improve the specific serological diagnosis of B. melitensis or B. ovis infection in sheep.  (+info)

Characterization of new members of the group 3 outer membrane protein family of Brucella spp. (5/78)

Impairment of the omp25 gene in Brucella spp. leads to attenuated strains and confers protection to the host. Omp25 and Omp31, whose functions remain unknown, were the first characterized members of group 3 outer membrane proteins (Omps) (25 to 34 kDa). Recently, genomic and proteomic approaches identified five new putative members of this family, some of which are produced in B. melitensis or B. abortus. In the present study, using protein microsequencing, we identified new members of group 3 Omps proteins produced in B. suis. Since several monoclonal antibodies (MAbs) against Omp25 cross-reacted with other members of group 3 Omps, we also performed Western immunoblotting to compare wild-type B. suis with mutants systematically having B. suis omp25-related genes knocked out. We demonstrate the production of three paralogs of Omp31 and/or Omp25 in B. suis, and the existence of a common site of signal peptide cleavage (AXAAD), which is very similar to that present in the five homologous Omps of Bartonella quintana. The seven group 3 Omps were classified in four-subgroups on the basis of percentage amino acid sequence identities: Omp25 alone, the Omp25b-Omp25c-Omp25d cluster, the Omp31/31b subgroup, and the less related Omp22 protein (also called Omp3b). Together with previous data, our results demonstrate that all new members of group 3 Omps are produced in B. suis or in other Brucella species and we propose a nomenclature that integrates all of these proteins to facilitate the understanding of future Brucella interspecies study results.  (+info)

VirB1 orthologs from Brucella suis and pKM101 complement defects of the lytic transglycosylase required for efficient type IV secretion from Agrobacterium tumefaciens. (6/78)

Type IV secretion systems mediate conjugative plasmid transfer as well as the translocation of virulence factors from various gram-negative pathogens to eukaryotic host cells. The translocation apparatus consists of 9 to 12 components, and the components from different organisms are believed to have similar functions. However, orthologs to proteins of the prototypical type IV system, VirB of Agrobacterium tumefaciens, typically share only 15 to 30% identical amino acids, and functional complementation between components of different type IV secretion systems has not been achieved. We here report a heterologous complementation in the case of A. tumefaciens virB1 defects with its orthologs from Brucella suis (VirB1s) and the IncN plasmid pKM101 (TraL). In contrast, expression of the genes encoding the VirB1 orthologs from the IncF plasmid (open reading frame 169) and from the Helicobacter pylori cag pathogenicity island (HP0523) did not complement VirB1 functions. The complementation of VirB1 activity was assessed by T-pilus formation, by tumor formation on wounded plants, by IncQ plasmid transfer, and by IncQ plasmid recipient assay. Replacement of the key active-site Glu residue by Ala abolished the complementation by VirB1 from B. suis and by TraL, demonstrating that heterologous complementation requires an intact lytic transglycosylase active site. In contrast, the VirB1 active-site mutant from A. tumefaciens retained considerable residual activity in various activity assays, implying that this protein exerts additional effects during the type IV secretion process.  (+info)

Impairment of intramacrophagic Brucella suis multiplication by human natural killer cells through a contact-dependent mechanism. (7/78)

Brucella spp. are facultative intracellular bacteria that can establish themselves and cause chronic disease in humans and animals. NK cells play a key role in host defense. They are implicated in an early immune response to a variety of pathogens. However, it was shown that they do not control Brucella infection in mice. On the other hand, NK cell activity is impaired in patients with acute brucellosis, and recently it was demonstrated that human NK cells mediate the killing of intramacrophagic Mycobacterium tuberculosis in in vitro infection. Therefore, we have analyzed the behavior of Brucella suis infecting isolated human macrophages in the presence of syngeneic NK cells. We show that (i) NK cells impair the intramacrophagic development of B. suis, a phenomenon enhanced by NK cell activators, such as interleukin-2; (ii) NK cells cultured in the presence of infected macrophages are highly activated and secrete gamma interferon and tumor necrosis factor alpha; (iii) impairment of bacterial multiplication inside infected cells is marginally associated with the cytokines produced during the early phase of macrophage-NK cell cocultures; (iv) direct cell-to-cell contact is required for NK cells to mediate the inhibition of B. suis development; and (v) inhibition of B. suis development results from an induction of NK cell cytotoxicity against infected macrophages. Altogether, these findings show that NK cells could participate early in controlling the intramacrophagic development of B. suis in humans. It seems thus reasonable to hypothesize a role for NK cells in the control of human brucellosis. However, by impairing the activity of these cells in the acute phase of the illness, the pathogen should avoid this control.  (+info)

Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence. (8/78)

By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.  (+info)

'Brucella suis' is a gram-negative, facultatively anaerobic coccobacillus that causes brucellosis in both humans and animals, particularly swine. It is one of several species in the genus *Brucella* that are pathogenic to humans. The infection can be acquired through contact with infected animals or consumption of contaminated food or drink. In humans, symptoms may include fever, sweats, malaise, headache, muscle and joint pain, and can lead to serious complications if not treated promptly and appropriately.

'Brucella' is a genus of gram-negative, facultatively intracellular bacteria that are causative agents of brucellosis, a zoonotic disease with various clinical manifestations in humans and animals. The bacteria are primarily hosted by domestic and wild animals, such as cattle, goats, pigs, and dogs, and can be transmitted to humans through direct contact with infected animals or consumption of contaminated animal products, such as unpasteurized milk and cheese.

There are several species of Brucella, including B. abortus, B. melitensis, B. suis, and B. canis, which primarily infect different animal hosts but can also cause disease in humans. The bacteria have a unique ability to survive and replicate within host cells, such as macrophages, allowing them to evade the immune system and establish chronic infection.

Human brucellosis is characterized by nonspecific symptoms, such as fever, fatigue, joint pain, and sweats, which can make diagnosis challenging. Treatment typically involves a long course of antibiotics, such as doxycycline and rifampin, to eradicate the infection. Prevention measures include pasteurization of dairy products, vaccination of animals, and use of personal protective equipment when handling animals or their products.

Brucellosis is a bacterial infection caused by the Brucella species, which are gram-negative coccobacilli. It is a zoonotic disease, meaning it can be transmitted from animals to humans. The most common way for humans to contract brucellosis is through consumption of contaminated animal products, such as unpasteurized milk or undercooked meat, from infected animals like goats, sheep, and cattle.

Humans can also acquire the infection through direct contact with infected animals, their tissues, or bodily fluids, especially in occupational settings like farming, veterinary medicine, or slaughterhouses. In rare cases, inhalation of contaminated aerosols or laboratory exposure can lead to brucellosis.

The onset of symptoms is usually insidious and may include fever, chills, night sweats, headache, muscle and joint pain, fatigue, and loss of appetite. The infection can disseminate to various organs, causing complications such as endocarditis, hepatomegaly, splenomegaly, orchitis, and epididymoorchitis.

Diagnosis is confirmed through blood cultures, serological tests, or molecular methods like PCR. Treatment typically involves a long course of antibiotics, such as doxycycline combined with rifampin or streptomycin. Prevention measures include pasteurization of dairy products and cooking meat thoroughly before consumption. Vaccination is available for high-risk populations but not for general use due to the risk of adverse reactions and potential interference with serodiagnosis.

'Brucella abortus' is a gram-negative, facultatively anaerobic coccobacillus that is the causative agent of brucellosis, also known as Bang's disease in cattle. It is a zoonotic disease, meaning it can be transmitted from animals to humans, and is typically acquired through contact with infected animal tissues or bodily fluids, consumption of contaminated food or drink, or inhalation of infectious aerosols.

In cattle, 'Brucella abortus' infection can cause abortion, stillbirths, and reduced fertility. In humans, it can cause a systemic illness characterized by fever, sweats, malaise, headache, and muscle and joint pain. If left untreated, brucellosis can lead to serious complications such as endocarditis, hepatomegaly, splenomegaly, and neurological symptoms.

Prevention measures include vaccination of cattle, pasteurization of dairy products, and implementation of strict hygiene practices in occupational settings where exposure to infected animals or their tissues is possible. Treatment typically involves a prolonged course of antibiotics, such as doxycycline and rifampin, and may require hospitalization in severe cases.

'Brucella melitensis' is a gram-negative, facultatively anaerobic coccobacillus that is the primary cause of brucellosis in humans. It is a zoonotic pathogen, meaning it can be transmitted from animals to humans, and is typically found in goats, sheep, and cattle.

Humans can become infected with 'Brucella melitensis' through direct contact with infected animals or their bodily fluids, consumption of contaminated food or drink (such as unpasteurized milk or cheese), or inhalation of infectious aerosols.

The infection can cause a range of symptoms including fever, headache, muscle and joint pain, fatigue, and swelling of the lymph nodes. In severe cases, it can lead to complications such as endocarditis, hepatitis, and neurological disorders.

Prevention measures include pasteurization of dairy products, cooking meat thoroughly, wearing protective clothing when handling animals or their tissues, and vaccination of at-risk populations. Treatment typically involves a long course of antibiotics, such as doxycycline and rifampin, and may require hospitalization in severe cases.

Streptococcus suis is a Gram-positive, beta-hemolytic streptococcus that is a significant pathogen in pig populations worldwide. It can cause a variety of clinical manifestations in pigs, including meningitis, arthritis, endocarditis, and septicemia. Transmission to humans can occur through contact with infected pigs or contaminated pork products, resulting in diseases such as meningitis, sepsis, endocarditis, and arthritis. There are 35 serotypes of S. suis, but only a few (including serotypes 1, 2, 4, 5, 9, 14, 16, 21, 24, and 31) are commonly associated with disease in pigs and humans.

A Brucella vaccine is a type of immunization used to protect against brucellosis, an infectious disease caused by bacteria of the genus Brucella. The most commonly used vaccine is the Brucella melitensis Rev-1 strain, which is administered to sheep and goats to prevent the spread of the disease to humans through contaminated food and animal contact.

The Brucella vaccine works by stimulating the immune system to produce a protective response against the bacteria. When the vaccinated animal encounters the actual bacterial infection, their immune system is better prepared to fight it off and prevent the development of clinical disease.

It's important to note that the Brucella vaccine is not approved for use in humans due to the risk of severe side effects and the possibility of causing a false positive result on brucellosis diagnostic tests. Therefore, it should only be administered to animals under the supervision of a veterinarian.

"Ochrobactrum anthropi" is a gram-negative, rod-shaped bacterium that is found in various environments, including soil, water, and clinical samples. It is a conditional pathogen, meaning it can cause infection under certain circumstances, particularly in immunocompromised individuals. Infections caused by Ochrobactrum anthropi are often associated with medical devices or procedures, such as catheter-related bacteremia, pneumonia, and wound infections. It is inherently resistant to many antibiotics, which can make treatment challenging.

'Brucella ovis' is a gram-negative, coccobacillus-shaped bacterium that belongs to the genus Brucella. It is a facultative intracellular pathogen that primarily causes contagious epididymitis and orchitis in rams (male sheep), leading to infertility and decreased flock productivity.

This bacterial species is host-adapted, meaning it mainly affects sheep and goats, and does not typically cause disease in humans. However, there have been rare cases of laboratory-acquired infections in people working with infected animals or their tissues.

'Brucella ovis' infection control measures include proper sanitation practices, the use of personal protective equipment (PPE), and vaccination programs for susceptible animal populations to minimize transmission and disease spread.

Virulence, in the context of medicine and microbiology, refers to the degree or severity of damage or harm that a pathogen (like a bacterium, virus, fungus, or parasite) can cause to its host. It is often associated with the ability of the pathogen to invade and damage host tissues, evade or suppress the host's immune response, replicate within the host, and spread between hosts.

Virulence factors are the specific components or mechanisms that contribute to a pathogen's virulence, such as toxins, enzymes, adhesins, and capsules. These factors enable the pathogen to establish an infection, cause tissue damage, and facilitate its transmission between hosts. The overall virulence of a pathogen can be influenced by various factors, including host susceptibility, environmental conditions, and the specific strain or species of the pathogen.

'Brucella canis' is a gram-negative, coccobacillus-shaped bacterium that belongs to the genus Brucella. It is the causative agent of brucellosis in dogs, also known as canine brucellosis. This disease primarily affects the reproductive system of dogs, causing infertility, abortion, and stillbirths.

Transmission of 'Brucella canis' typically occurs through contact with infected placental material, vaginal discharges, semen, or urine from infected animals. It can also be spread through contaminated objects such as bedding or feeding dishes. The bacterium can survive in the environment for extended periods, increasing the risk of transmission.

In addition to reproductive issues, 'Brucella canis' infection can cause other health problems in dogs, including lymphadenopathy (enlarged lymph nodes), discospondylitis (inflammation of the spinal column), and uveitis (inflammation of the eye). Diagnosis is typically made through blood tests or culture of infected tissues. Treatment can be challenging due to the bacterium's ability to survive within host cells, and antibiotic therapy may need to be prolonged.

While 'Brucella canis' infection is not common in humans, it can cause a flu-like illness that may progress to more severe symptoms such as endocarditis or neurological disorders. Therefore, individuals who handle infected dogs or their tissues should take appropriate precautions to minimize the risk of transmission.

'Agrobacterium tumefaciens' is a gram-negative, soil-dwelling bacterium that is known for its ability to cause plant tumors or crown galls. It does this through the transfer and integration of a segment of DNA called the Ti (Tumor-inducing) plasmid into the plant's genome. This transferred DNA includes genes that encode enzymes for the production of opines, which serve as a nutrient source for the bacterium, and genes that cause unregulated plant cell growth leading to tumor formation.

This unique ability of 'Agrobacterium tumefaciens' to transfer and integrate foreign DNA into plants has been exploited in genetic engineering to create transgenic plants with desired traits. The Ti plasmid is often used as a vector to introduce new genes into the plant genome, making it an essential tool in plant biotechnology.

Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis ... the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis ... Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic ... Brucella suis is differentiated into five biovars (strains), where biovars 1-3 infect wild boar and domestic pigs, and biovars ...
Brucella suis Wyatt HV (2014). "How did Sir David Bruce forget Zammit and his goats ?" (PDF). Journal of Maltese History. Malta ... Brucella species survive well in aerosols and resist drying. Brucella and all other remaining biological weapons in the U.S. ... suis (caribou and pigs). Brucella species have also been isolated from several marine mammal species (cetaceans and pinnipeds ... In 1954, B. suis became the first agent weaponized by the United States at its Pine Bluff Arsenal near Pine Bluff, Arkansas. ...
Each M114 held 320 milliliters of Brucella suis. Smart, Jeffery K. Medical Aspects of Chemical and Biological Warfare Archived ...
... abortus, Brucella canis, Brucella neotomae, Brucella ovis, and Brucella suis are all synonyms of Brucella melitensis. ... 3,193 ORFs Brucella pinnipedialis B2/94, 3,505 ORFs Brucella suis 1330, 3,408 ORFs Genome data for these and other Brucella ... Brucella abortus A13334, 3,401 ORFs Brucella canis ATCC 23365, 3,408 ORFs Brucella melitensis 16M, 3,279 ORFs Brucella microti ... Hofer E (2009). "Microbiological diagnosis of Brucella spp. and Austrian epidemiology of brucellosis (B. suis biovar 2)" (PDF ...
Wolves can catch Brucella suis from wild and domestic reindeer. While adult wolves tend not to show any clinical signs, it can ...
In Brucella suis 1330 RNA sequencing identified a novel list of 33 sRNAs and 62 Hfq-associated mRNAs. In Brucella melitensis ... 2015). "Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing". J. Bacteriol. 198 (3): ... sRNA BM-sr0117 from Brucella melitensis was identified and shown to be bound to and cleaved by Bm-RNase III. AbcR and AbcR2 ( ... Bacterial small RNAs (sRNA) are an important class of regulatory molecules in bacteria such as Brucella. They are often bound ...
Brucella abortus (Q57B94), Brucella suis (Q8FYS0) and Brucella melitensis (Q8YJ29). The biochemical mechanism of proline ...
The U.S. Army Chemical Corps selected Brucella suis as its first mass-produced biological agent in 1949. Tests at Dugway ... The M33 cluster bomb was a 500-pound (227 kg) biological munition that initially carried the biological agent Brucella suis. ... Besides B. suis the M33 was tested with other agents throughout the 1950s. The M33 was an air-released munition: released at ... The M33 cluster bomb, also known as the (M33) Brucella cluster bomb, was a U.S. biological cluster bomb developed in the early ...
... the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis ... 2002). "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts". Proc. Natl ... 2002). "The genome sequence of the facultative intracellular pathogen Brucella melitensis". Proc. Natl. Acad. Sci. U.S.A. 99 (1 ... 2005). "Whole-genome analyses of speciation events in pathogenic Brucellae". Infection and Immunity. 73 (12): 8353-61. doi: ...
... one being Brucella abortus. Some of the other species are known as B. melitensis, B. canis, B. suis, B. ovis, B. neotomae, B. ... "Humans and Brucella Species". "Brucellosis: Brucella Abortus" (PDF). Kaden, R.; Ferrari, S.; Jinnerot, T.; Lindberg, M.; Wahab ... Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The ... Brucella abortus enters phagocytes that invade human and animal innate defenses which in turn, cause chronic disease in the ...
... synonym for Brucella suis Brucella melitensis biovar Suis str. 1330, synonym for Brucella suis 1330 Brucella suis bv. 1 ... 1 Brucella abortus bv. 1 str. 9-941 Brucella abortus bv. 2 Brucella abortus bv. 3 Brucella abortus bv. 4 Brucella melitensis ... synonym for Brucella neotomae Brucella melitensis biovar Ovis, synonym for Brucella ovis Brucella melitensis biovar Suis, ... a synonym for Brucella canis Brucella melitensis biovar Melitensis Brucella melitensis bv. 1 Brucella melitensis bv. 2 Brucella ...
... which is caused by Brucella suis. The original weaponized form used the M114 bursting bomblet in M33 cluster bombs. While the ... Brucella, Tularemia, etc. Viral agents: Smallpox, Viral hemorrhagic fevers, etc. Toxins: Botulinum, Ricin, etc. The earliest ...
... and Brucella suis, the causitive agent of Brucellosis. The M33 cluster bomb was used in a series of tests from August-October ... with the Army Chemical Corps exposing over 11,000 guinea pigs to Brucella suis. The guinea pig trials caused one Chemical Corps ...
Studies on the bactericidal action of bovine whole blood and serum towards Brucella abortus and Brucella suis. J. Infect. Dis. ...
Bio-agents tested there included Bacillus anthracis, Coxiella burnetii, Francisella tularensis, Brucella suis, Rickettsia ...
Campbell, M., Boulanger, J. and Lee, D. unpublished: Demographic Effects of an Outbreak of Brucella suis On Island Bound Barren ...
... and Brucella suis (a cause of brucellosis). Production of biological agents in Building 470 ceased in 1965 and all production ...
Brucella suis, Coxiella burnetii, Venezuelan equine encephalitis virus, Staphylococcal enterotoxin B). The United States ... Agents considered for weaponization, or known to be weaponized, include bacteria such as Bacillus anthracis, Brucella spp., ...
... known as Brucella suis Chlamydia suis, an infection affecting pigs Pseudomonas suis, a bacterium that causes pneumonia in pigs ... Look up suis in Wiktionary, the free dictionary. Suis, a Latin adjective referring to the pig, may refer to: Swine brucellosis ... suis, a mite subspecies Suis, the vocalist in the Japanese rock duo Yorushika Sui (disambiguation) This disambiguation page ... Streptococcus suis, a pathogen affecting pigs Trichuris suis, a worm species used in helminthic therapy Trypanosoma suis, a ...
Brucella suis, Coxiella burnetii, Venezuelan equine encephalitis virus, Staphylococcal enterotoxin B). The use of chemicals to ...
Brucella suis, Coxiella burnetii, Venezuelan equine encephalitis virus, Staphylococcal enterotoxin B). Since 1997, United ...
Brucella suis, Rickettsia prowazekii, Variola major (smallpox), Yersinia pestis, botulinum toxin, and Venezuelan equine ...
Brucella suis ATCC 23445 chromosome I (NC_010169), Bm16Mr7CI = Brucella melitensis bv. 1 str. 16M chromosome I (NC_003317), ... Brucella suis 1330 chromosome I (NC_004310), Ba19941r7CI = Brucella abortus bv. 1 str. 9-941 chromosome I (NC_006932), Bmar7CI ... Brucella melitensis biovar Abortus 2308 chromosome I (NC_007618), Bor7CI = Brucella ovis ATCC 25840 chromosome I (NC_009505), ... Bmir7CI = Brucella microti CCM 4915 chromosome 1 (NC_013119), Oar7CI = Brucella anthropi ATCC 49188 chromosome 1 (NC_009667), ...
Bordetella bronchiseptica Bordetella pertussis Borrelia burgdorferi Brucella Brucella abortus Brucella melitensis Brucella suis ...
Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei* (formerly Pseudomonas mallei) Burkholderia pseudomallei ...
... caused by Brucella suis Q-fever, caused by Coxiella burnetii botulism Staphylococcal Enterotoxin B (SEB), toxin produced by ...
Brucella melitensis MeSH B03.440.400.425.215.500.625 - Brucella ovis MeSH B03.440.400.425.215.500.750 - Brucella suis MeSH ... Brucella melitensis MeSH B03.660.050.070.100.625 - Brucella ovis MeSH B03.660.050.070.100.750 - Brucella suis MeSH B03.660. ... Brucella MeSH B03.440.400.425.215.500.100 - Brucella abortus MeSH B03.440.400.425.215.500.150 - Brucella canis MeSH B03.440. ... Brucella MeSH B03.660.050.070.100.100 - Brucella abortus MeSH B03.660.050.070.100.150 - Brucella canis MeSH B03.660.050.070. ...
Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella ... B. canis was said to be a biovar of B. suis. With recent research, PCR assay data was able to contradict B. canis and B. suis. ... rather than phenol-water like smooth forms of Brucella are known to be. Colonies of Brucella can typically start to be seen ... Brucella canis can be found in both pets and wild animals and lasts the lifespan of the animal it has affected. B. canis has ...
Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis ... the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis ... Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic ... Brucella suis is differentiated into five biovars (strains), where biovars 1-3 infect wild boar and domestic pigs, and biovars ...
... 19(12). Fretin, David et al. "Unexpected Brucella suis ... Brucella suis infection was diagnosed in a man from Tonga, Polynesia, who had butchered swine in Oregon, USA. Although the US ... "Unexpected Brucella suis Biovar 2 Infection in a Dairy Cow, Belgium" vol. 19, no. 12, 2013. Export RIS Citation Information.. ... Title : Unexpected Brucella suis Biovar 2 Infection in a Dairy Cow, Belgium Personal Author(s) : Fretin, David;Mori, Marcella; ...
1962). Isolation of Brucella suis from air of slaughterhouse. 77(7). Harris, Marvin M. et al. "Isolation of Brucella suis from ... Title : Isolation of Brucella suis from air of slaughterhouse Personal Author(s) : Harris, Marvin M.;Hendricks, Stanley L.; ... "Isolation of Brucella suis from air of slaughterhouse" vol. 77, no. 7, 1962. Export RIS Citation Information.. ...
Brucella suis The survival of Brucella under environmental conditions is a relatively important factor in the transmission of ...
Three types of the bacteria that cause brucellosis - Brucella abortus, Brucella melitensis and Brucella suis - are designated ... Since B. suis is normally found in pigs, wild hog (feral swine) hunters are at risk of becoming infected when they field dress ... Exposure to most species of Brucella, such as those associated with certain types of animals, could potentially lead to ... Human Neurobrucellosis with Intracerebral Granuloma Caused by a Marine Mammal Brucella spp. ...
Brucella suis * Treponema pallidum * Corynebacterium bovis * Actinobacilli Cytomegalovirus (CMV), coxsackievirus, Epstein-Barr ...
This Brucella spp. MSDS/PSDS, provided by PHAC, is offered here as a FREE public service to visitors of www.EHS.com. ... Brucella spp.. Brucella spp. (B. abortus, B. canis, B. melitensis, B. suis). MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES ... NAME: Brucella spp. (B. abortus, B. canis, B. melitensis, B. suis). SYNONYM OR CROSS REFERENCE: Brucellosis, Undulant fever, ... PATHOGENICITY: All Brucella isolates are potentially pathogenic to humans; systemic bacterial disease with acute or insidious ...
We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of Brucell … ... is a worldwide disease of humans and livestock that is caused by a number of very closely related classical Brucella species in ... We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of Brucella suis 1330 ... the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis J ...
Categories: Brucella suis Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 24 ...
LOINC Code 24387-3 Brucella sp IgG Ab [Presence] in Serum by Immunoassay ... The main pathogenic species of Brucella are Brucella melitensis, Brucella suis and Brucella abortus. Brucella melitensis is a ... Brucella are gram-negative coccobacilli that commonly infect cows (Brucella abortus), pigs (Brucella suis), goats (Brucella ... Brucella IgG Ser Ql IA. Display Name. Brucella sp IgG IA Ql (S). Consumer Name Alpha Get Info. Brucella sp IgG antibody, Blood ...
Brucella abortus (cultures only). Brucella melitensis (cultures only). Brucella suis (cultures only). Burkholderia mallei - ...
Brucella canis, Brucella melitensis and Brucella suis) and Cryptosporosis (Cryptospora neoformans) and Pasteurellosis from ...
ki je prosto okužbe z Brucella abortus, B. melitensis in B. suis za ovce in koze(10); ter ... 2020/692 testirane za okužbo z Brucella abortus, B. melitensis in B. suis z negativnim rezultatom na vzorcu, odvzetem v 30 dneh ... in okužbi z Brucella abortus, B. melitensis in B. suis ter ... v katerem okužba z Brucella ovis (kužni epididimitis) ni bila ... in so bili v 30 dneh pred datumom odpreme v Unijo serološko testirani za odkrivanje Brucella ovis z negativnim rezultatom;] (1) ...
Ten species are recognized within the genus Brucella. There are 6 "classical" species: B. abortus, B. melitensis, B. suis, B. ... M. J. Corbel, M. Banai, and I. Genus, "Brucella Meyer and Shaw 1920, 173AL," in Bergeys Manual of Systematic Bacteriology, D. ... V. L. Atluri, M. N. Xavier, M. F. de Jong, A. B. den Hartigh, and R. M. Tsolis, "Interactions of the human pathogenic Brucella ... As a principle, if a specific antibody against bovine Brucella is present in the serum, then antigen-antibody complex is formed ...
Brucellosis is a zoonotic infection caused by the bacterial genus Brucella. The bacteria are transmitted from animals to humans ... Brucella suis. Pigs (biotype 1-3). South America, Southeast Asia, United States ... Celebi G, Külah C, Kiliç S, Ustündag G. Asymptomatic Brucella bacteraemia and isolation of Brucella melitensis biovar 3 from ... Brucella has the potential to be used as a biologic weapon, [5] but to date, these organisms have not been implicated in any ...
The bacteria Brucella causes brucellosis, an infectious zoonotic disease in humans. Learn how to prevent brucellosis, and read ... The major species of the genus Brucella that cause the disease are B. melitensis, B. suis, B. abortus, and B. canis; these are ... Brucellosis is in infectious disease caused by bacteria in the genus Brucella. Brucella are aerobic, gram-negative coccobacilli ... Brucella bacteria can enter the human body through mucous membranes, breaks in the skin, the respiratory tract, ...
Brucella melitensis,. B. abortus,. B. suis, Coxiella burnetii,. Francisella tularensis,. Listeria monocytogenes,. Mycobacterium ...
gi,23500268,ref,NP_699708.1, sugar ABC transporter, ATP-binding protein [Brucella suis 1330] gi,23463875,gb,AAN33713..... ... gi,17989095,ref,NP_541728.1, MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK [Brucella melitensis] gi,2529712.... ...
Brucella suis Seroprevalence and Associated Risk Factors in Dogs in Eastern Australia, 2016 to 2019. November 16, 2021. ...
Brucella suis Seroprevalence and Associated Risk Factors in Dogs in Eastern Australia, 2016 to 2019. November 16, 2021. ...
Brucellas were not isolated under the surveillance initiative to provide evidence that pig herds remain free of Brucella suis; ... Streptococcus suis incidents There were 11 incidents of Streptococcus suis infection; four (36.4%) were serotype 2. There were ... Streptococcus suis isolates: Twenty-five Streptococcus suis isolates were serotyped this quarter: ... Actinobacillus suis was isolated in septicaemic distribution from 4-week-old pigs that had a sudden rise in mortality ...
Brucella abortus / suis (CF) [Referral]. Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (BAPA). Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (FPA). Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (Card Agglutination). Detection of antibodies to Brucella abortus and Brucella suis, the causative ...
Brucella abortus / suis (CF) [Referral]. Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (BAPA). Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (FPA). Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of ... Brucella abortus / suis (Card Agglutination). Detection of antibodies to Brucella abortus and Brucella suis, the causative ...
Standard Method Performance Requirements (SMPR®) for DNA-Based Methods of Detecting Brucella suis in Field-Deployable and ...
Brucella abortus, B. canis, B. suis and especially B. melitensis are able to cause human infection [2]. The only species ... Infected animals secrete Brucella spp. in large numbers in the uterine fluids, as well as in milk [2]. During miscarriage the ... This Brucella rich fluid will contaminate the environment and the rear parts of the animal exposing animal handlers, especially ... In Jordan, the only isolated Brucella species is B. melitensis [4]. Although, B. melitensis infects cattle with high morbidity ...
... suis), and dogs (B. canis). Worldwide, brucellosis usually occurs in geographic areas with large populations of these animal ... Human Exposure to Brucella abortus Strain RB51 -- Kansas, 1997 MMWR 47(09);172-175 Publication date: 03/13/1998. Table of ... One element of the cooperative state and federal brucellosis eradication efforts is the use of approved Brucella vaccines on ... Editorial Note: Brucellosis, also known as undulant fever or Bangs disease, is a systemic infection caused by Brucella sp ...
Brucella Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of Brucella. ... There are four main species of Brucella that cause disease in humans: Brucella abortus, Brucella melitensis, Brucella suis, and ... and it groups together several species including Brucella abortus, Brucella melitensis, Brucella canis and Brucella suis. ... Now, Brucella can enter the body one of two ways. First, there may be direct contact with infected animals - and the host is ...
Brucella species of greatest one-health relevance in the US include those infecting dogs (Brucella canis), swine (Brucella suis ... and cattle and domestic bison (Brucella abortus). Although not endemic in the US, Brucella melitensis warrants awareness as it ... Diagnosis and treatment of brucellosis is challenging due to the limitations of diagnostic assays and the tendency of Brucella ... This review will focus on zoonotic considerations for Brucella spp found within the US along with their epidemiology, ...
  • Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis, B. abortus, B. ovis, B. canis) are recognized as potential agricultural, civilian, and military bioterrorism agents. (wikipedia.org)
  • Three types of the bacteria that cause brucellosis - Brucella abortus , Brucella melitensis and Brucella suis - are designated as select agents. (cdc.gov)
  • We report the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of Brucella suis 1330 and Brucella melitensis 16 M. The genomes of these Brucella species are strikingly similar, with nearly identical genetic content and gene organization. (nih.gov)
  • Several fragments previously identified as unique to either B. suis or B. melitensis were present in the B. abortus genome. (nih.gov)
  • Even though several fragments were shared between only B. abortus and B. suis, B. abortus shared more fragments and had fewer nucleotide polymorphisms with B. melitensis than B. suis. (nih.gov)
  • Brucella are gram-negative coccobacilli that commonly infect cows (Brucella abortus), pigs (Brucella suis), goats (Brucella melitensis), and dogs (Brucella canis), along with wild animals such as deer, elk, and moose. (loinc.org)
  • The main pathogenic species of Brucella are Brucella melitensis, Brucella suis and Brucella abortus. (loinc.org)
  • Brucella melitensis is a gram-negative coccobacillus bacterium from the Brucellaceae family. (loinc.org)
  • Similar to B. melitensis, B. suis can cause abortion in pregnant hosts. (loinc.org)
  • Human infections are caused most frequently by B. melitensis, B. suis, and B. abortus, while B. canis causes only rare infections. (loinc.org)
  • Brucella melitensis is particularly common in the Mediterranean basin and it has also been reported in Africa, India, and Mexico [ 6 ]. (hindawi.com)
  • The most pathogenic (likely to cause disease) species are B. melitensis and B. suis . (medicinenet.com)
  • small Gram-negative coccobacilli that can infect cattle (infection with B. abortus), goats and sheep (B. melitensis), pigs (B. suis), and dogs (B. canis). (cdc.gov)
  • Brucella is a genus of Gram-negative coccobacilli, and it groups together several species including Brucella abortus , Brucella melitensis, Brucella canis and Brucella suis. (osmosis.org)
  • So, B. abortus is transmitted by cattle, B. melitensis is transmitted by small ruminants such as goats and sheep, B. canis is transmitted by dogs and B. suis is transmitted by swine and rodents. (osmosis.org)
  • Although not endemic in the US, Brucella melitensis warrants awareness as it poses a risk to international travelers. (avma.org)
  • 本病主要由流產布氏桿菌(B. abortus)、馬爾他布氏桿菌(B. melitensis)、豬布氏桿菌(B (gov.tw)
  • Human brucellosis cases are rare in non-endemic countries, such as Germany, where infections are predominantly caused by Brucella melitensis. (bvsalud.org)
  • Brucella abortus (B. abortus), Brucella melitensis (B. melitensis), and Brucella suis (B. suis) are the most virulent of the brucellae, but the traditional detection methods to distinguish them are time-consuming and require high instrumentation. (bvsalud.org)
  • The causative organisms of human brucellosis are B. abortus (from cattle), B. melitensis (from sheep and goats), and B. suis (from hogs). (msdmanuals.com)
  • Generally, B. melitensis and B. suis are more pathogenic than other Brucella species. (msdmanuals.com)
  • B. suis and especially B. melitensis are able ment during the period January to July made or where the item(s) were usually to cause human infection [2]. (who.int)
  • The Brucella abortus (rough LPS Brucella) vaccine, developed for bovine brucellosis and licensed by the USDA Animal Plant Health Inspection Service, has shown protection for some swine and is also effective against B. suis infection, but there is currently no approved vaccine for swine brucellosis. (wikipedia.org)
  • Brucella abortus is a species of the genus Brucella. (loinc.org)
  • Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of brucellosis, using buffered acidified plate antigen (BAPA). (tamu.edu)
  • Detection of antibodies to Brucella abortus and Brucella suis, the causative agents of brucellosis, by card agglutination. (tamu.edu)
  • On May 26-27, 1997, nine persons (a farmer, four veterinary clinicians, and four veterinary students) in Manhattan, Kansas, participated in an attempted vaginal delivery, a cesarean delivery, and a necropsy on a stillborn calf that died because of Brucella abortus infection. (cdc.gov)
  • Brucella species of greatest one-health relevance in the US include those infecting dogs ( Brucella canis ), swine ( Brucella suis ), and cattle and domestic bison ( Brucella abortus ). (avma.org)
  • While brucellosis has been eradicated from domestic livestock in the US, its detection in US companion animals ( B canis ) and US wildlife reservoirs ( B suis and B abortus ) and enzootic presence internationally pose a threat to human and animal health, warranting its spotlight on the one-health stage. (avma.org)
  • To develop an effective bivalent vaccine for swine against these two diseases, a leucine auxotroph of the USDA approved vaccine B. abortus strain RB51 was constructed along with leuB gene complementing plasmid pNS4 to over-express antigens from Brucella and influenza. (vt.edu)
  • For example, Leal-Klevezas and colleagues stated that detectable amounts of antibodies are not recorded in the first 12-16 days after artificial inoculation of goats with Brucella abortus [ 19 ]. (biomedcentral.com)
  • Finally, people can become infected with Brucella RB51, a strain of B abortus that is used to vaccinate cattle in the United States and other parts of the world. (medscape.com)
  • New diseases such as Seoulvirus-infections via kept rats, tick-borne encephalit is infections via ticks, and in animals Brucella canis and Brucella suis have been found in the past few years. (rivm.nl)
  • The separation of B. canis from B. suis bv 3, however, failed. (biomedcentral.com)
  • and dogs ( Brucella canis ), among others. (preventingwithexperts.com)
  • However, B canis and Brucella RB51 won't show up on serology, so culture is needed to confirm the infection. (medscape.com)
  • Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. (wikipedia.org)
  • Blood cultures grew Brucella suis exposed to swine brucellosis by temporary movement of biovar 1. (cdc.gov)
  • Brucellosis is a worldwide disease of humans and livestock that is caused by a number of very closely related classical Brucella species in the alpha-2 subdivision of the Proteobacteria. (nih.gov)
  • When humans come in contact with an infected animal or animal products that are contaminated with Brucella, brucellosis may result. (loinc.org)
  • Brucellosis is in infectious disease caused by bacteria in the genus Brucella . (medicinenet.com)
  • None of the exposed persons reported having previously had brucellosis or being unintentionally inoculated with Brucella vaccine. (cdc.gov)
  • Editorial Note: Brucellosis, also known as 'undulant fever' or 'Bangs disease,' is a systemic infection caused by Brucella sp. (cdc.gov)
  • Diagnosis and treatment of brucellosis is challenging due to the limitations of diagnostic assays and the tendency of Brucella spp to produce nonspecific, insidious clinical signs and evade antimicrobial therapy, making prevention essential. (avma.org)
  • Swine brucellosis caused by Brucella suis and swine influenza caused by Influenza A virus affect both domestic and feral swine populations. (vt.edu)
  • Brucellosis is a widespread zoonosis of great economic importance caused by facultative intracellular Gram-negative bacteria belonging to the genus Brucella . (biomedcentral.com)
  • The German National Reference Laboratory for Bovine, Porcine, Ovine and Caprine Brucellosis received a suspected Brucella sp. (bvsalud.org)
  • Brucella suis, the causative agent of brucellosis, poses a significant public health and animal husbandry threat. (bvsalud.org)
  • Brucella is the causative agent of brucellosis and can be transmitted to humans through aerosolized particles or contaminated food. (bvsalud.org)
  • Brucellosis is caused by Brucella species, which are gram-negative bacteria. (msdmanuals.com)
  • Although brucellosis is mainly a bacterial disease of animals, several species of Brucella bacteria are known to cause disease in humans. (medscape.com)
  • In the United States, 25%-30% of brucellosis cases are due to B suis and almost all are diagnosed in people who hunt and slaughter feral swine. (medscape.com)
  • Brucellae are Gram-negative, facultative intracellular bacteria that can infect many species of animals and man. (hindawi.com)
  • Brucella bacteria can enter the human body through mucous membranes, breaks in the skin, the respiratory tract, gastrointestinal tract, and even the conjunctiva . (medicinenet.com)
  • If animals like sheep, goats, buffalo, cows, or camels are infected with Brucella , the milk they produce is contaminated with the bacteria. (medicinenet.com)
  • Although this risk is generally associated with people who work in laboratories studying Brucella organisms, it is possible that people working in meat-processing areas could be exposed to the bacteria by inhalation of droplets from contaminated meat (cattle, sheep). (medicinenet.com)
  • Now, Brucella it's a non-motile bacteria that doesn't form spores. (osmosis.org)
  • Now, Brucella is a very slow growing bacteria, so colonies usually grow in the solid medium after 6 to 8 weeks of incubation. (osmosis.org)
  • The bacteria, Streptococcus suis ( S. suis ) causes significant disease in swine operations worldwide. (capata.online)
  • S. suis is a highly varied species, containing 35 variations of the bacteria, called serotypes. (capata.online)
  • Almost 100% of farms (and almost 100% of pigs within farms) are colonized by S. suis , mainly in the tonsils ("carrier state" - pigs are healthy, but carry the bacteria). (capata.online)
  • S. suis has been isolated from many other animal species, although their role in the carry and spread of the bacteria has not been proven. (capata.online)
  • A commercial biotyping system (Taxa Profile™, Merlin Diagnostika) testing the metabolization of various substrates by bacteria was used to determine if a set of phenotypic features will allow the identification of members of the genus Brucella and their differentiation into species and biovars. (biomedcentral.com)
  • Based on specific and stable reactions a 96-well " Brucella identification and typing" plate (Micronaut™) was designed and re-tested in 113 Brucella isolates and a couple of closely related bacteria. (biomedcentral.com)
  • Bacteriological tests and PCR-based diagnostics showed the isolate to be B. suis, but did not yield cohesive results regarding the biovar. (bvsalud.org)
  • Species and biovar classification of brucellae is historically based on natural host preference and phenotypic traits, i.e. (biomedcentral.com)
  • Phylogeography and epidemiology of Brucella suis biovar 2 in wildlife and domestic swine. (cdc.gov)
  • The most frequent clinical sign following B. suis infection is abortion in pregnant females, reduced milk production, and infertility. (wikipedia.org)
  • Exposure to most species of Brucella , such as those associated with certain types of animals, could potentially lead to infection. (cdc.gov)
  • A common route of Brucella infection is eating or drinking infected dairy products that have not been pasteurized. (loinc.org)
  • [ 7 ] Surprisingly, infection with Brucella species accounts for as many as 10% of laboratory-acquired infections, 24% of laboratory-acquired bacterial infections, and 11% of occupational-exposure deaths in the United States. (medscape.com)
  • S. suis colonizes the tonsils of most pigs and is capable of causing disease in the brain via meningitis (brain barrier inflammation) and through septicemia (bloodstream infection), thus reaching other organs. (capata.online)
  • In Australia the Brucella suis infection is only known to occur in feral pigs, not domestic pigs. (beefcentral.com)
  • Regarding the second group of animals, the IS 711 real-time PCR detected infection in 26% of animals, while Brucella spp. (biomedcentral.com)
  • infection has largely been eliminated from commercial cattle and swine with aggressive vaccination, there is a significant prevalence of Brucella sp. (bvsalud.org)
  • Cattle can also be transiently infected when they share pasture or facilities with infected pigs, and B. suis can be transmitted by cow's milk. (wikipedia.org)
  • Brucella suis is differentiated into five biovars (strains), where biovars 1-3 infect wild boar and domestic pigs, and biovars 1 and 3 may cause severe diseases in humans. (wikipedia.org)
  • Since B. suis is normally found in pigs, wild hog (feral swine) hunters are at risk of becoming infected when they field dress infected pigs. (cdc.gov)
  • Brucella suis infections in pigs causes chronic inflammatory lesions in the reproductive organs or orchitis and may affect joints and/or other organs. (loinc.org)
  • S. suis is also a zoonotic agent able to cause serious disease (mostly meningitis) in people working with pigs or pork-derived products. (capata.online)
  • It has been shown that pigs can carry S. suis for more than 500 days and medication does not eliminate the carrier state. (capata.online)
  • Feral pigs are known to carry a number of zoonotic diseases, including Brucella suis, leptospirosis and Q fever. (beefcentral.com)
  • Strains of highly pathogenic Brucella have been considered to be used as a biological weapon because the organisms can be aerosolized and then easily inhaled. (medicinenet.com)
  • Ten species are recognized within the genus Brucella . (hindawi.com)
  • The comprehensive testing of metabolic activity allows cluster analysis within the genus Brucella . (biomedcentral.com)
  • The aim of our study was to develop a miniaturised semi-automated system for the reliable identification of members of the genus Brucella and the differentiation of its species based on comprehensive metabolic activity testing. (biomedcentral.com)
  • The source of antigenic cross-reactions is the O-chain of the smooth lipopolysaccharide (S-LPS) present on the surface of the bacterial cell, which shows great similarity in smooth Brucella spp. (biomedcentral.com)
  • Using commercially available rapid bacterial identification systems such as the API 20 NE ® (BioMerieux, Nürtingen, Germany) which include a restricted number of biochemical tests Brucella spp. (biomedcentral.com)
  • This review will focus on zoonotic considerations for Brucella spp found within the US along with their epidemiology, pathophysiology, clinical presentation, treatment, and control strategies. (avma.org)
  • Flagellar genes, however, are present in the B. suis genome, but are thought to be cryptic remnants because some were truncated and others were missing crucial components of the flagellar apparatus. (wikipedia.org)
  • Brucella suis are differentiated into five strains. (loinc.org)
  • Against a virulent challenge of B. suis, the candidate vaccine strain over-expressing both SOD and WboA protected mice more significantly than the control group and was also found to be better protective than other candidate vaccine strains over-expressing either SOD and L7/L12 together or SOD alone. (vt.edu)
  • There are many strains of S. suis, some that are considered commensal or opportunistic while others have the potential to cause severe disease. (capata.online)
  • The biotyping system developed for the identification of Brucella and differentiation of its species and biovars may replace or at least complement time-consuming tube testing especially in case of atypical strains. (biomedcentral.com)
  • A biotyping assay useful for Brucella identification and species differentiation must consequently be able to identify the rising number of upcoming new species as well as single atypical strains which do not fit within the pre-existing scheme [ 10 , 11 ]. (biomedcentral.com)
  • Due to their typical metabolic profiles a differentiation of Brucella isolates to the species level could be achieved. (biomedcentral.com)
  • B. suis are gram-negative, facultative intracellular coccobacilli and can specifically produce in phagocytic cells. (loinc.org)
  • Brucella are aerobic, gram-negative coccobacilli. (medicinenet.com)
  • Brucella is a gram-negative coccobacilli that can infect humans and animals. (osmosis.org)
  • Brucella suis is a Gram-negative, facultative, intracellular coccobacillus, capable of growing and reproducing inside of host cells, specifically phagocytic cells. (wikipedia.org)
  • Because B. suis is facultative and intracellular, and is able to adapt to environmental conditions in macrophages, treatment failure and relapse rates are high. (wikipedia.org)
  • Furthermore, there has been a marked increase in S. suis cases recently, mainly in herds who have reduced and/or eliminated the use of preventive medications (Poeta Silva, 2021). (capata.online)
  • Some cases in humans in North America have been traced to pork from hogs infected with B suis . (medscape.com)
  • Transmission of S. suis between herds occurs mainly through the introduction of healthy carrier animals. (capata.online)
  • In conclusion, this dissertation describes the construction of an environmentally safe antigen over-expression platform and successful employment of the system as a candidate vaccine in protecting mice against B. suis challenge. (vt.edu)
  • However, Brucella has a few virulence factors that it uses to avoid destruction. (osmosis.org)
  • Commonly infected animals that are hunted that may contain Brucella are caribou, moose, wild hogs (feral hogs), elk, and bison. (medicinenet.com)
  • IS 711 -based real-time PCR assay as a tool for detection of Brucella spp. (biomedcentral.com)
  • In the present study, we describe the evaluation of the recently established real-time PCR assay based on the Brucella -specific insertion sequence IS 711 with blood samples from 199 wild boars (first group of animals) and tissue samples from 53 wild boars (second group of animals) collected in Switzerland. (biomedcentral.com)
  • The results presented here indicate that IS 711 real-time PCR assay is a specific and sensitive tool for detection of Brucella spp. (biomedcentral.com)
  • Maternal antibodies (immune response component) are normally present since most sows possess high amounts of antibodies against S. suis . (capata.online)
  • In addition, the B. suis gene for nickel transport, nikA, is activated by metal ion deficiency and is expressed once in the phagosome. (wikipedia.org)
  • However, the role of the alanine racemase (alr) gene, which encodes alanine racemase in Brucella, remains unclear. (bvsalud.org)
  • however, B. suis is endemic among feral from animals of US origin was in process at the time of this investigation, few had been sequenced. (cdc.gov)
  • On the bright side, there are now some modern automated blood culture systems called the Bactec systems, which are more effective and can isolate Brucella after only 1 week. (osmosis.org)
  • The isolate was found to be B. suis bv. (bvsalud.org)
  • Based on in silico genotyping it could be excluded that the isolate was identical to one of the B. suis bv. (bvsalud.org)
  • Here, we analyzed an alr deletion mutant and a complemented strain of Brucella suis S2. (bvsalud.org)
  • Brucella species and biovars revealed characteristic metabolic profiles and each strain showed an individual pattern. (biomedcentral.com)
  • While S. suis is most often associated with meningitis, other manifestations include arthritis, polyserositis (widespread membrane inflammation), endocarditis (heart valve inflammation) and, as a secondary cause, pneumonia (lung inflammation). (capata.online)
  • First, there may be direct contact with infected animals - and the host is different for each Brucella species. (osmosis.org)
  • Some reports indicate that the intestine may also be a reservoir and, from there, S. suis may invade the bloodstream of animals. (capata.online)
  • Most clinical diagnostic laboratories are able to run serologic tests, which detect an antibody response to most of the Brucella species. (medscape.com)
  • tify such events to prevent the re-establishment of B. suis in Matthew M. Erdman the commercial swine herd and to protect workers. (cdc.gov)
  • Summary: Brucella suis encounters a macrophage, but no oxidative burst occurs. (wikipedia.org)
  • We report the surgical treatment of a ruptured mycotic aneurysm of the abdominal aorta due to Brucella suis in a woman living in a rural community with a large population of feral swine. (bvsalud.org)
  • citation needed] B. suis possesses smooth lipopolysaccharide (LPS), which has a full-length O-chain, as opposed to rough LPS, which has a truncated or no O-chain. (wikipedia.org)
  • Each species of Brucella has distinct risk factors. (medscape.com)
  • Commonly used disinfectants can kill S. suis in less than 1 minute, even at concentrations less than those recommended by the manufacturers. (capata.online)