OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Brucella melitensisBrucellosisBrucellaBrucella abortusBrucella VaccineBrucella ovisBrucella suisSheep DiseasesBrucellosis, BovineGoatsRose BengalGoat DiseasesBrucella canisAntibodies, BacterialDoxycyclineAntigens, BacterialAntibodies, ImmobilizedSheepBacterial ProteinsBacterial Outer Membrane ProteinsMicrobiologyAgglutination TestsMice, Inbred BALB CDNA, BacterialStreptomycinGenome, BacterialVirulence
Brucella melitensis
A species of the genus BRUCELLA whose natural hosts are sheep and goats. Other mammals, including humans, may be infected. In general, these organisms tend to be more virulent for laboratory animals than BRUCELLA ABORTUS and may cause fatal infections.
Brucellosis
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Brucella
A genus of gram-negative, aerobic bacteria that causes BRUCELLOSIS. Its cells are nonmotile coccobacilli and are animal parasites and pathogens. The bacterium is transmissible to humans through contact with infected dairy products or tissue.
Brucella abortus
A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. Abortion and placentitis are frequently produced in the pregnant animal. Other mammals, including humans, may be infected.
Brucella Vaccine
A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.
Brucella ovis
A species of the genus BRUCELLA which are pathogenic to SHEEP.
Brucella suis
A species of gram-negative bacteria, primarily infecting SWINE, but it can also infect humans, DOGS, and HARES.
Sheep Diseases
Diseases of domestic and mountain sheep of the genus Ovis.
Brucellosis, Bovine
A disease of cattle caused by bacteria of the genus BRUCELLA leading to abortion in late pregnancy. BRUCELLA ABORTUS is the primary infective agent.
Goats
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
Rose Bengal
A bright bluish pink compound that has been used as a dye, biological stain, and diagnostic aid.
Goat Diseases
Diseases of the domestic or wild goat of the genus Capra.
Brucella canis
A species of gram-negative bacteria infecting DOGS, the natural hosts, and causing canine BRUCELLOSIS. It can also cause a mild infection in humans.
Antibodies, Bacterial
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Doxycycline
A synthetic tetracycline derivative with similar antimicrobial activity.
Antigens, Bacterial
Substances elaborated by bacteria that have antigenic activity.
Antibodies, Immobilized
Antibodies that are chemically bound to a substrate material which renders their location fixed.
Sheep
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Bacterial Proteins
Proteins found in any species of bacterium.
Bacterial Outer Membrane Proteins
Proteins isolated from the outer membrane of Gram-negative bacteria.
Microbiology
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Agglutination Tests
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
Mice, Inbred BALB C
DNA, Bacterial
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Streptomycin
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Genome, Bacterial
The genetic complement of a BACTERIA as represented in its DNA.
Virulence
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

Performance of competitive and indirect enzyme-linked immunosorbent assays, gel immunoprecipitation with native hapten polysaccharide, and standard serological tests in diagnosis of sheep brucellosis. (1/314)

Competitive and standard enzyme-linked immunosorbent assays (ELISAs), rose bengal (RB), complement fixation, and agar gel immunoprecipitation with native hapten (AGID-NH) were compared by using sera from Brucella-free, Brucella melitensis-infected, and B. melitensis Rev1-vaccinated sheep. The most sensitive tests were indirect ELISA and RB, and the most specific tests were AGID-NH and competitive ELISA. We show that RB followed by AGID-NH is a simple and effective system for diagnosing sheep brucellosis.  (+info)

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs. (2/314)

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.  (+info)

Effect of early antibiotic treatment on the antibody response to cytoplasmic proteins of Brucella melitensis in mice. (3/314)

To test whether antibiotic therapy hampers the antibody response to Brucella antigens, 30 BALB/c mice were infected with Brucella melitensis H38 and randomized for treatment with doxycycline administered intraperitoneally for 42 days starting at 7 or 28 days postinfection (p.i.) (groups DOX7 and DOX28, respectively) or for no treatment (control group). Antibodies to smooth lipopolysaccharide (LPS) reached peak levels (mean optical density [OD] = 2.618) between days 56 and 70 p.i. in the control group, and similar peak levels (mean OD = 2.486) were observed in the DOX28 group, but significantly lower peak levels (mean OD = 0.821) were observed at 28 days p.i. in the DOX7 group. The antibody response against cytoplasmic proteins depleted of LPS (CPs) reached maximal levels (mean OD = 2.402) between days 56 and 70 p.i. in the control group, but no response was detected in the DOX7 group. Anti-CP antibodies were detected in only three animals from the DOX28 group, at levels significantly lower than those in the control group (mean maximal OD = 0.791). The pattern of antibody response to an 18-kDa cytoplasmic protein of Brucella spp. was similar to that against the CP antigen. This study shows that early antibiotic treatment affects the antibody response of mice to cytoplasmic proteins of Brucella and, to a lesser extent, to LPS.  (+info)

Molecular characterization of a Brucella species large DNA fragment deleted in Brucella abortus strains: evidence for a locus involved in the synthesis of a polysaccharide. (4/314)

A Brucella melitensis 16M DNA fragment of 17,119 bp, which contains a large region deleted in B. abortus strains and DNA flanking one side of the deletion, has been characterized. In addition to the previously identified omp31 gene, 14 hypothetical genes have been identified in the B. melitensis fragment, most of them showing homology to genes involved in the synthesis of a polysaccharide. Considering that 10 of the 15 genes are missing in B. abortus and that all the polysaccharides described in the Brucella genus (lipopolysaccharide, native hapten, and polysaccharide B) have been detected in all the species, it seems likely that the genes described here might be part of a cluster for the synthesis of a novel Brucella polysaccharide. Several polysaccharides have been identified as important virulence factors, and the discovery of a novel polysaccharide in the brucellae which is probably not synthesized in B. abortus might be interesting for a better understanding of the pathogenicity and host preference differences observed between the Brucella species. However, the possibility that the genes described in this paper no longer encode the synthesis of a polysaccharide cannot be excluded. Brucellae belong to the alpha-2 subdivision of the class Proteobacteria, which includes other microorganisms living in association with eucaryotic cells, some of them synthesizing extracellular polysaccharides involved in the interaction with the host cell. The genes described in this paper might be a remnant of the common ancestor of the alpha-2 subdivision of the class Proteobacteria, and the brucellae might have lost such extracellular polysaccharide during evolution if it was not necessary for survival or for establishment of the infectious process. Nevertheless, further studies are necessary to identify the entire DNA fragment missing in B. abortus strains and to elucidate the mechanism responsible for such deletion, since only 9,948 bp of the deletion was present in the sequenced B. melitensis DNA fragment.  (+info)

Identification of an IS711 element interrupting the wboA gene of Brucella abortus vaccine strain RB51 and a PCR assay to distinguish strain RB51 from other Brucella species and strains. (5/314)

Brucella abortus vaccine strain RB51 is a natural stable attenuated rough mutant derived from the virulent strain 2308. The genetic mutations that are responsible for the roughness and the attenuation of strain RB51 have not been identified until now. Also, except for an assay based on pulsed-field gel electrophoresis, no other simple method to differentiate strain RB51 from its parent strain 2308 is available. In the present study, we demonstrate that the wboA gene encoding a glycosyltransferase, an enzyme essential for the synthesis of O antigen, is disrupted by an IS711 element in B. abortus vaccine strain RB51. Exploiting this feature, we developed a PCR assay that distinguishes strain RB51 from all other Brucella species and strains tested.  (+info)

Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK). (6/314)

Human brucellosis can be acquired from infected animal tissues by ingestion, inhalation, or contamination of the conjunctiva or traumatized skin by infected animal products. A vaccine to protect humans from occupational exposure or from zoonotic infection in areas where the disease is endemic would reduce an important cause of morbidity worldwide. Vaccines currently used in animals are unsuitable for human use. We tested a live, attenuated, purine-auxotrophic mutant strain of Brucella melitensis, WR201, for its ability to elicit cellular and humoral immune responses and to protect mice against intranasal challenge with B. melitensis 16M. Mice inoculated intraperitoneally with WR201 made serum antibody to lipopolysaccharide and non-O-polysaccharide antigens. Splenocytes from immunized animals released interleukin-2 (IL-2), gamma interferon, and IL-10 when cultured with Brucella antigens. Immunization led to protection from disseminated infection but had only a slight effect on clearance of the challenge inoculum from the lungs. These studies suggest that WR201 should be further investigated as a vaccine to prevent human brucellosis.  (+info)

Brucellar spondylitis: review of 35 cases and literature survey. (7/314)

Thirty-five patients aged 14-74 years (average, 54 years) who had brucellar spondylitis were treated between January 1991 and December 1997. The time from onset of symptoms to diagnosis of spondylitis ranged from 1 week to 8 months (median, 9 weeks). Back or neck pain (100% of patients), fever (66%), and constitutional symptoms (57%) were the most common symptoms. Cultures of blood specimens from 26 patients (74%) were positive for Brucella melitensis. The duration of antimicrobial therapy (median, 120 days; range, 45-535 days) varied according to clinical response and the presence of epidural and paravertebral masses. One of the 35 patients underwent surgical treatment of a spinal epidural abscess. Therapy failed for 9 patients (26%; 95% confidence interval [CI], 12%-43%), and 5 (14%; 95% CI, 5%-30%) had a relapse. There were no deaths or severe sequelae in this study. Brucellar spondylitis causes considerable suffering and absenteeism from work, but long-term clinical responses are favorable.  (+info)

Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitro. (8/314)

Entry of opsonized pathogens into phagocytes may benefit or, paradoxically, harm the host. Opsonization may trigger antimicrobial mechanisms such as reactive oxygen or nitric oxide (NO) production but may also provide a safe haven for intracellular replication. Brucellae are natural intramacrophage pathogens of rodents, ruminants, dogs, marine mammals, and humans. We evaluated the role of opsonins in Brucella-macrophage interactions by challenging cultured murine peritoneal macrophages with Brucella melitensis 16M treated with complement- and/or antibody-rich serum. Mouse serum rich in antibody against Brucella lipopolysaccharide (LPS) (aLPS) and human complement-rich serum (HCS) each enhanced the macrophage uptake of brucellae. Combinations of suboptimal levels of aLPS (0. 01%) and HCS (2%) synergistically enhanced uptake. The intracellular fate of ingested bacteria was evaluated with an optimal concentration of gentamicin (2 microg/ml) to control extracellular growth but not kill intracellular bacteria. Bacteria opsonized with aLPS and/or HCS grew equally well inside macrophages in the absence of gamma interferon (IFN-gamma). Macrophage activation with IFN-gamma inhibited replication of both opsonized and nonopsonized brucellae but was less effective in inhibiting replication of nonopsonized bacteria. IFN-gamma treatment of macrophages with opsonized or nonopsonized bacteria enhanced NO production, which was blocked by N(G)-monomethyl L-arginine (MMLA), an NO synthesis inhibitor. MMLA also partially blocked IFN-gamma-mediated bacterial growth inhibition. These studies suggest that primary murine macrophages have limited ability to control infection with B. melitensis, even when activated by IFN-gamma in the presence of highly opsonic concentrations of antibody and complement. Additional cellular immune responses, e.g., those mediated by cytotoxic T cells, may play more important roles in the control of murine brucellosis.  (+info)

O-chain expression in the rough Brucella melitensis strain B115: induction of O-polysaccharide-specific monoclonal antibodies...O-chain expression in the rough Brucella melitensis strain B115: induction of O-polysaccharide-specific monoclonal antibodies...
Spleen cells from mice infected with the rough Brucella melitensis strain B115 were fused with NSO myeloma cells. Hybridoma supernatants were screened in ELISA with cell walls (CW), sonicated cell extracts (CE) and rough lipopolysaccharide (R-LPS) of B. melitensis strain B115 and whole B. melitensis B115 cells. Surprisingly, 22 monoclonal antibodies (mAbs) reacting in ELISA with both CW and CE but not with R-LPS and bacterial cells were shown by immunoblot analysis and ELISA to react with smooth lipopolysaccharide (S-LPS). These mAbs also reacted in ELISA with O polysaccharides (OPS) from the smooth Brucella abortus strain 99 and the smooth B. melitensis strain 16M and thus recognize epitopes present on the O-chain. Proteinase K LPS preparations from B. melitensis B115 analysed by immunoblotting with one mAb (12G12) recognizing S-LPS of both A and M specificity displayed the typical S-LPS high-molecular-mass ladder pattern but no S-LPS was detected in the phenol/water/chloroform/light petroleum LPS
https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-138-6-1211
A case of Brucella melitensis endocarditis in a patient with cardiovas | IDRA case of Brucella melitensis endocarditis in a patient with cardiovas | IDR
A case of Brucella melitensis endocarditis in a patient with cardiovascular implantable electronic device Wasl Al-Adsani, Ali Ahmad, Mohammad Al-Mousa Department of Internal Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Preferred first-line treatment in adults with uncomplicated, nonlocalized disease consists of doxycycline–aminoglycoside combination. The recommended duration of treatment is 6 weeks. Cardiovascular implantable electronic device (CIED) infection caused by brucellosis is rare and has been reported in a few case study series. We report a case of Brucella melitensis infection of CIED where, contrary to most authorities
https://www.dovepress.com/a-case-of-brucella-melitensis-endocarditis-in-a-patient-with-cardiovas-peer-reviewed-fulltext-article-IDR
Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene...Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene...
Brucella melitensis bacteria cause persistent, intracellular infections in small ruminants as well as in humans, leading to significant morbidity and economic loss worldwide. The majority of experiments on the transcriptional responses of Brucella to conditions inside the host have been performed following invasion of cultured mammalian cells, and do not address gene expression patterns during long-term infection. Here, we examine the application of the previously developed coincidence cloning methodology to recover and characterize B. melitensis RNA from the supramammary lymph node of experimentally-infected goats. Using coincidence cloning, we successfully recovered Brucella RNA from supramammary lymph nodes of B. melitensis-infected goats at both short-term (4 weeks) and long-term (38 weeks) infection time points. Amplified nucleic acid levels were sufficient for analysis of Brucella gene expression patterns by RNA-sequencing, providing evidence of metabolic activity in both the short-term and the
https://bmcmolbiol.biomedcentral.com/articles/10.1186/s12867-018-0111-x/figures/6
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1...Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1...
Pathogens infecting mammalian cells have developed various strategies to suppress and evade their hosts defensive mechanisms. In this line, the intracellular bacteria that are able to survive and propagate within their host cells must have developed strategies to avert their hosts killing attitude. Studying the interface of host-pathogen confrontation can provide valuable information for defining therapeutic approaches. Brucellosis, caused by the Brucella strains, is a zoonotic bacterial disease that affects thousands of humansand animals around the world inflicting discomfort and huge economic losses. Similar to many other intracellular dwelling bacteria, infections caused by Brucella are difficult to treat, and hence any attempt at identifying new and common therapeutic targets would prove beneficial for the purpose of curing infections caused by the intracellular bacteria. In THP-1 macrophage infected with Brucella melitensis we studied the expression levels of four hosts genes, i.e. EMP2, ST8SIA4
http://ijvr.shirazu.ac.ir/article_3290.html
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
Fingerprint Dive into the research topics of Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. Together they form a unique fingerprint. ...
https://researchportal.unamur.be/en/publications/replication-of-brucella-abortus-and-brucella-melitensis-in-fibrob/fingerprints/
Brucella endocarditis caused by brucella melitensis
We present a rare case of brucella endocarditis, forming a vegetation on the mitral valve. The definitive diagnosis has been made with clinical suspicion, positive serology, the demonstration of the vegetation with the echocardiography and with the production from the multiple blood culture of brucella melitensis and from the excised valve. Our patient has been successfully treated with specific antibiotherapy and the surgery of replacement of mitral valve. Our aim in presenting the case is to remind the infective endocarditis which is due to this factor in the regions like our country which is endemic for ...
http://connection.ebscohost.com/c/case-studies/101634984/brucella-endocarditis-caused-by-brucella-melitensis
Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with...Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with...
Brucella spp. are the etiological agents of brucellosis, a zoonotic infectious disease that causes abortion in animals and chronic debilitating illness in humans. Natural Brucella infections occur primarily through an incompletely defined mechanism of adhesion to and penetration of mucosal epithelium. In this study, we characterized changes in genome-wide transcript abundance of the most and the least invasive growth phases of B. melitensis cultures to HeLa cells, as a preliminary approach for identifying candidate pathogen genes involved in invasion of epithelial cells. B. melitensis at the late logarithmic phase of growth are more invasive to HeLa cells than mid-logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase (the most invasive culture) compared to the stationary growth phase (the least invasive culture). As expected, the majority of up-regulated genes in late-log phase cultures were
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-9-81
Presence of two independent chromosomes in the Brucella melitensis 16M genome. | Journal of BacteriologyPresence of two independent chromosomes in the Brucella melitensis 16M genome. | Journal of Bacteriology
Mapping the restriction fragments of the Brucella melitensis 16M genome with a new restriction endonuclease, PacI, which cut the DNA into only eight fragments, indicated that this species contains two unique and independent replicons of about 2,100 and 1,150 kb. Pulsed-field gel electrophoresis of intact DNA revealed two bands migrating the expected distances. These replicons were identified as two unique and independent chromosomes by the presence of rRNA operons and genes for heat shock proteins mapping to separate replicons. ...
https://jb.asm.org/content/175/3/701?ijkey=db0a2fcf5f6c6e57fa6bc3eb77fef5e1530790b5&keytype2=tf_ipsecsha
Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival | BMC...Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival | BMC...
Random gene inactivation used to identify cellular functions associated with virulence and survival of Brucella spp has relied heavily upon the use of the transposon Tn5 that integrates at G/C base pairs. Transposons of the mariner family do not require species-specific host factors for efficient transposition, integrate nonspecifically at T/A base pairs, and, at a minimum, provide an alternative approach for gene discovery. In this study, plasmid vector pSC189, containing both the hyperactive transposase C9 and transposon terminal inverted repeats flanking a kanamycin resistance gene, were used to deliver Himar1 transposable element into the B. melitensis genome. Conjugation was performed efficiently and rapidly in less than one generation in order to minimize the formation of siblings while assuring the highest level of genome coverage. Although previously identified groups or classes of genes required for virulence and survival were represented in the screen, additional novel identifications were
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-6-102/figures/2
In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs |...In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs |...
Brucellae grow and replicate in the phagolysosomes of macrophages, where the pH is 5.0 (8). Antimicrobials that penetrate this compartment and act under acidic conditions might be used as monotherapy. Only doxycycline and rifampin met these criteria, and neither is effective as monotherapy for brucellosis (9, 13). The fluoroquinolones and azithromycin had good activity at pH 7.0 but not at pH 5.0. Garcia-Rodriguez et al. (7) also found that the activity of fluoroquinolones against brucellae was two to fourfold lower at pH 5.0 than at pH 7.0. These data are supported by results of animal and clinical studies: azithromycin was less effective than doxycycline alone or with streptomycin for experimental brucellosis in mice (6), and Al-Sibai et al. (3) reported a 25% relapse rate with oral ciprofloxacin given for 6 to 8 weeks. We obtained somewhat better clinical results with oral ofloxacin, but the relapse rate was still 15% after 4 weeks (1). No relationship between in vitro susceptibility and ...
https://aac.asm.org/content/43/5/1298?ijkey=110af8df921d1cb738d233637aa9ecbc3db94eab&keytype2=tf_ipsecsha
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy -...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
https://researchportal.unamur.be/en/publications/replication-of-brucella-abortus-and-brucella-melitensis-in-fibrob/equipments/
ICD-10 Diagnosis Code A23.0 Brucellosis due to Brucella melitensisICD-10 Diagnosis Code A23.0 Brucellosis due to Brucella melitensis
Diagnosis Code A23.0 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
https://icdlist.com/icd-10/a230
HOGENOM: BRUMB 1 PE1003
ID BRUMB_1_PE1003 STANDARD; PRT; 44 AA. AC BRUMB_1_PE1003; C0RJ20; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Putative uncharacterized protein; (BRUMB_1.PE1003). GN OrderedLocusNames=BMEA_A1086; OS BRUCELLA MELITENSIS ATCC 23457. OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; OC Brucella. OX NCBI_TaxID=546272; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BRUMB_1.PE1003. CC Brucella melitensis ATCC 23457 chromosome chromosome I, complete sequen CC sequence. CC -!- ANNOTATIONS ORIGIN:C0RJ20_BRUMB CC -!- GENE_FAMILY: HBG000000000 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; C0RJ20; -. DR EMBL; CP001488; ACO00828.1; -; Genomic_DNA. DR RefSeq; YP_002732782.1; NC_012441.1. DR GeneID; 7677846; -. DR GenomeReviews; CP001488_GR; BMEA_A1086. DR KEGG; bmi:BMEA_A1086; -. DR ProtClustDB; CLSK2476470; -. DR HOGENOMDNA; BRUMB_1.PE1003; -. ...
http://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=BRUMB_1_PE1003&db=HOGENOM&ident=ACNUC9435
In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31...In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31...
Designing a potent recombinant vaccine, using the appropriate subunits with the greatest effect on stimulating the immune system, especially in the case of intracellular pathogens such as gram negative Brucella Melitensis bacteria, is of great importance. In this study, three repeats of 27 amino acids of the immunogenic epitope derived from OMP31 antigen (3E) from the Brucella melitensis, in a protective manner against Brucellosis have been used. To fortify the delivery system of recombinant antigens, IL-2 cytokine as a molecular adjuvant was fused to recombinant constructs. Recombinant proteins were evaluated for immunological studies in a mouse model (BALB/c). The results showed that all recombinant proteins could stimulate the immune system to produce Th1 cytokines and antibodies in compare to the negative control treatments. 3E-IL2 and then OMP31-IL2 proteins stimulated higher levels of IFN-γ and IL-2 compared to the other treatments (p | 0.05). Also, the results indicated that experimental
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-2074-7
Study of the organization of the genomes of Escherichia coli, Brucella melitensis and Agrobacterium tumefaciens by insertion of...Study of the organization of the genomes of Escherichia coli, Brucella melitensis and Agrobacterium tumefaciens by insertion of...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/7582002?dopt=Abstract
Normal Goat Serum (1000 ml) Antibody | NORMAL SERUM AND IMMUNOGLOBULIN PRODUCTS | CapralogicsNormal Goat Serum (1000 ml) Antibody | NORMAL SERUM AND IMMUNOGLOBULIN PRODUCTS | Capralogics
Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010 May;16(5):544-50 Abstract. Liang L, Leng D, Burk C, Nakajima-Sasaki R, Kayala MA, Atluri VL, Pablo J, Unal B, Ficht TA, Gotuzzo E, Saito M, Morrow WJ, Liang X, Baldi P, Gilman RH, Vinetz JM, Tsolis RM, Felgner PL. Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens. PLoS Negl Trop Dis. 2010 May 4;4(5):e673 Full Text. Spindler SR, Ortiz I, Fung S, Takashima S, Hartenstein V Drosophila cortex and neuropile glia influence secondary axon tract growth, pathfinding, and fasciculation in the developing larval brain. Dev Biol. 2009 Oct 15;334(2):355-68 Abstract. El Annan J, Chauhan SK, Ecoiffier T, Zhang Q, Saban DR, D. Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3802-7 Abstract. ...
https://www.capralogics.com/normal-serum-and-immunoglobulin-products/normal-goat-serum-1000-ml
accA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Brucella melitensis biotype 1 (strain 16M / ATCC...accA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Brucella melitensis biotype 1 (strain 16M / ATCC...
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
https://www.uniprot.org/uniprot/Q8YJP3
Normal Sheep IgG Protein G Purified Antibody | NORMAL SERUM AND IMMUNOGLOBULIN PRODUCTS | CapralogicsNormal Sheep IgG Protein G Purified Antibody | NORMAL SERUM AND IMMUNOGLOBULIN PRODUCTS | Capralogics
Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010 May;16(5):544-50 Abstract. Liang L, Leng D, Burk C, Nakajima-Sasaki R, Kayala MA, Atluri VL, Pablo J, Unal B, Ficht TA, Gotuzzo E, Saito M, Morrow WJ, Liang X, Baldi P, Gilman RH, Vinetz JM, Tsolis RM, Felgner PL. Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens. PLoS Negl Trop Dis. 2010 May 4;4(5):e673 Full Text. Spindler SR, Ortiz I, Fung S, Takashima S, Hartenstein V Drosophila cortex and neuropile glia influence secondary axon tract growth, pathfinding, and fasciculation in the developing larval brain. Dev Biol. 2009 Oct 15;334(2):355-68 Abstract. El Annan J, Chauhan SK, Ecoiffier T, Zhang Q, Saban DR, D. Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3802-7 Abstract. ...
https://www.capralogics.com/normal-serum-and-immunoglobulin-products/normal-sheep-igg-protein-g-purified
KEGG PATHWAY: Sulfur metabolism - Brucella melitensis M28
Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3-phosphoadenylyl sulfate (PAPS) and then reduced ...
http://www.genome.jp/kegg-bin/show_pathway?bmz00920
Brucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilmBrucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilm
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Antimicrobial susceptibility of Brucella spp. isolated from Iranian patients during 2016 to 2018 | Iranian Journal of...Antimicrobial susceptibility of Brucella spp. isolated from Iranian patients during 2016 to 2018 | Iranian Journal of...
Results: In this study, sixty B. melitensis strains were isolated from blood samples (16%) and all them belonged to biovar 1. Majority of the tested antibacterial agents, excepting ampicillin-sulbactam had an effective activity against B. melitensis isolates in E-test (MIC) and disk diffusion method. Moreover, probable resistance to rifampin and ampicillin-sulbactam were observed in 60 (100%), 1 (1.7%), 11 (18.4%) and 2 (3.4%) isolates, respectively ...
https://ijm.tums.ac.ir/index.php/ijm/article/view/2124
Evaluation fo Live Attenuated B. Melitensis Vaccines in Nonhuman Primates - Thomas FichtEvaluation fo Live Attenuated B. Melitensis Vaccines in Nonhuman Primates - Thomas Ficht
The goal of our proposed research is to develop a Brucella vaccine that is safe for human use. Our approach has explored the use of live attenuated vaccines, si...
http://grantome.com/grant/NIH/U54-AI057156-09-6317
mediaTUM - Media and Publication ServermediaTUM - Media and Publication Server
Brucella spp. are zoonotic Gram-negative intracellular pathogens with the ability to survive and replicate in phagocytes. It has been shown that bacterial proteins expressed abundantly in this niche are stress-related proteins capable of triggering effective immune responses. BMEI1549 is a molecular chaperone designated DnaK that is expressed under stress conditions and helps to prevent formation of protein aggregates. In order to study the potential of DnaK as a prospective Brucella subunit vaccine, immunogenicity and protective efficacy of recombinant DnaK from Brucella melitensis was evaluated in BALB/c mice. The dnak gene was cloned, expressed in Escherichia coli, and the resulting recombinant protein used as subunit vaccine. DnaK-immunized mice showed a strong lymphocyte proliferative response to in vitro antigen stimulation. Although comparable levels of antigen-specific IgG2a and IgG1 were observed in immunized mice, high amounts of IFN-?, IL-12 and IL-6, no detectable level of IL-4 and ...
http://mediatum.ub.tum.de/1254179?id=1254179&change_language=en
January | 2020 | PKA Inhibitors
Ann Inst Pasteur Microbiol 1987,138(2):235-238.PubMedCrossRef 11. Grimont F, Verger JM, Cornelis Kinase Inhibitor Library cell line P, Limet J, Lefevre M, Grayon M, Regnault B, Van Broeck J, Grimont PA: Molecular typing of Brucella with cloned DNA probes. Res Microbiol 1992,143(1):55-65.PubMedCrossRef 12. Cerri D, Ebani VV, Pedrini A, Nuvoloni R, Renzoni G, Andreani E, Farina R: Epididymitis by Brucella ovis : experimental infection in virgin ram lambs. New Microbiol 1999,22(3):227-231.Z-IETD-FMK price PubMed 13. Davis CE, Troy SB: Brucellosis. N Engl J Med 2005,353(10):1071-1072. author reply 1071-1072PubMedCrossRef 14. Fenkci V, Cevrioglu S, Yilmazer M: Ovarian abscess due to Brucella melitensis . Scand J Infect Dis 2003,35(10):762-763.PubMedCrossRef. 15. Pappas G, Akritidis N, Bosilkovski M, Tsianos E: Brucellosis. N Engl J Med 2005,352(22):2325-2336.PubMedCrossRef 16. Troy SB, Rickman CP-690550 LS, Davis CE: Brucellosis in San Diego: epidemiology and species-related differences in acute ...
https://pkainhibitors.com/2020/01
Brucellosis - Oxford MedicineBrucellosis - Oxford Medicine
There are four species of the Gram-negative, aerobic brucella bacillus, each comprising several biovars: Brucella melitensis (Malta fever, most commonly associated with goats, sheep, and camels), B. abortus (cattle), B. suis (pigs), and B. canis (dogs). The disease that they cause-brucellosis-occurs worldwide, but is especially prevalent in the Mediterranean region, the Indian subcontinent, Mexico, and Central and South America. Transmission is commonly by ingestion of untreated dairy products or other contaminated foods, but can also be by inhalation or inoculation....
http://oxfordmedicine.com/view/10.1093/med/9780199204854.001.1/med-9780199204854-chapter-070621
PublicationsPublications
Impact Factor: 2,450 2015. Markowicz M, Kivaranovic D, Stanek G. Testing patients with non-specific symptoms for antibodies against Borrelia burgdorferi sensu lato does not provide useful clinical information about their aetiology. Clin Microbiol Infect. 2015 Aug 29. pii: S1198-743X(15)00791-0. doi: 10.1016/j.cmi.2015.08.005. [Epub ahead of print] Markowicz M, Ladstatter S, Schötta AM, Reiter M, Pomberger G, Stanek G. Oligoarthritis caused by Borrelia bavariensis, Austria, 2014. Emerg Infect Dis. 2015 Jun;21(6):1052-4. doi: 10.3201/eid2106.141516. Reiter, M., A. Schötta, A. Müller, H. Stockinger, and G. Stanek. A newly established real-time PCR for detection of Borrelia miyamotoi in Ixodes ricinus ticks. Ticks and Tick-Borne Diseases 6:303 (2015) 2014. Tobudic S., K. Nedomansky, W. Poeppl, M. Müller, A. Faas, G. Mooseder, F. Allerberger, G. Stanek, H. Burgmann. Seroprevalence for Coxiella burnetii, Francisella tularensis, Brucella abortus and Brucella melitensis in Austrian adults: a ...
https://www.meduniwien.ac.at/hp/en/hai/research-groups/immunology-of-infection-and-microbiology/publications/
FUN 05 | SSGCID
FUN_05: Use the SSGCID solved structure of Brucella melitensis methionine-tRNA-synthetase (MetRS) to find inhibitors for potential drug development for brucellosis.
https://www.ssgcid.org/target-status/functional/fun_05/
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Onze cas de brucellose ont été identifiés dans deux municipalités de Cordoba (Andalousie, Espagne). Une étude cas-témoins a été menée en prenant trois cas pour un témoin. Les cas avaient consommé du fromage non pasteurisé produit dans une ferme située dans la zone épidémique et présentaient un risque plus élevé de contracter la brucellose que les témoins ( OR = 21.6, IC95% = 1.6-639.8). Brucella melitensis serovar 3 a été identifié dans des prélèvements cliniques, des tissus de chèvre et des échantillons de lait provenant du troupeau de la ferme. Des mesures préventives ont été mises en place et l'épidémie s'est terminé après que tous les fromages suspects aient été retirés du marché. Des mesures d'hygiène plus importantes ont été instaurées à la ferme, ainsi que des actions de promotion de la santé.
https://www.eurosurveillance.org/content/10.2807/esm.08.07.00421-fr
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En tres municipios de Córdoba (Andalucía, España) se identificaron once casos de brucelosis. Se realizó un estudio de casos y controles, seleccionando tres casos por cada control. Las personas que consumieron queso de cabra fresco sin higienizar elaborado en una granja situada en el territorio epidémico, presentaban un mayor riesgo de padecer brucelosis (OR=21,6, IC 95%=1,6-639,8). Se identificó Brucella melitensis serotipo 3 en muestras clínicas, y en tejido de cabras y muestras de leche de la granja del rebaño. Se adoptaron medidas preventivas y el brote fue contenido tras la retirada del mercado de todos los quesos sospechosos, la desinfección y limpieza adicional de la granja y la realización de actividades de promoción sanitaria.
http://www.eurosurveillance.org/content/10.2807/esm.08.07.00421-es
Molecular targets for rapid identification of Brucella sppMolecular targets for rapid identification of Brucella spp
Although not all of the differentiating genes identified were transcribed under steady state conditions, a group of genes sufficient to discriminate unambiguously between B. suis, B. melitensis, and B. abortus was identified. We present an overview of these genomic differences and the use of these f …
https://pubmed.ncbi.nlm.nih.gov/16504063/
PROSITEPROSITE
TCPA_CRIGR (P18279 ), TCPA_DICDI (Q55BM4 ), TCPA_DROME (P12613 ), TCPA_ENCCU (Q8SSC9 ), TCPA_HUMAN (P17987 ), TCPA_MACFA (Q4R5G2 ), TCPA_MONDO (Q9XT06 ), TCPA_MOUSE (P11983 ), TCPA_PALPA (Q9W790 ), TCPA_RAT (P28480 ), TCPA_SCHMA (Q94757 ), TCPA_SCHPO (O94501 ), TCPA_TETPY (O15891 ), TCPA_YEAST (P12612 ), TCPB_ARATH (Q940P8 ), TCPB_BOVIN (Q3ZBH0 ), TCPB_CAEEL (P47207 ), TCPB_DICDI (Q54ES9 ), TCPB_HUMAN (P78371 ), TCPB_MACFA (Q4R6F8 ), TCPB_MESAU (P86245 ), TCPB_MOUSE (P80314 ), TCPB_RAT (Q5XIM9 ), TCPB_SCHPO (Q10147 ), TCPB_YEAST (P39076 ), TCPD_ARATH (Q9LV21 ), TCPD_ASHGO (Q75A36 ), TCPD_BOVIN (Q2T9X2 ), TCPD_CAEEL (P47208 ), TCPD_CANGA (Q6FQT2 ), TCPD_DEBHA (Q6BXF6 ), TCPD_DICDI (Q54CL2 ), TCPD_HUMAN (P50991 ), TCPD_KLULA (Q6CL82 ), TCPD_MOUSE (P80315 ), TCPD_OCHTR (Q9NB32 ), TCPD_PONAB (Q5R637 ), TCPD_RAT (Q7TPB1 ), TCPD_SCHPO (P50999 ), TCPD_TAKRU (P53451 ), TCPD_YARLI (Q6C100 ), TCPD_YEAST (P39078 ), TCPE1_AVESA (P40412 ), TCPE2_AVESA (P54411 ), TCPE_ARATH (O04450 ), TCPE_CAEEL (P47209 ), ...
http://prosite.expasy.org/PS00995
KEGG SSDB Paralog Search Result: bme:BMEI1248KEGG SSDB Paralog Search Result: bme:BMEI1248
T00072 (acav,adh,amin,apom,arn,arx,asoc,ato,bacs,balt,bara,barw,bcae,bko,camg,cmb,def,fln,frm,gli,gtm,lagl,les,lzy,mbov,mee,ntp,ntt,parb,part,pcx,pht,ppoa,ptu,rhu,sbj,sgv,slau,smal,sphd,sscu,sya,tpaf,trl : calculation not yet completed ...
http://www.kegg.jp/ssdb-bin/ssdb_paralog?org_gene=bme:BMEI1248
iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major...iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major...
Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of Leishmania growth absolutely requires expression of inducible Nitric Oxide Synthase (iNOS/NOS2) and subsequent production of NO. Here, we show that CD11b+ CD11c+ Ly-6C+ MHC-II+ cells are the main iNOS-producing cells in the footpad lesion and in the draining lymph node of Leishmania major-infected C57BL/6 mice. These cells are phenotypically similar to iNOS-producing inflammatory DC (iNOS-DC) observed in the mouse models of Listeria monocytogenes and Brucella melitensis infection. The use of DsRed-expressing parasites demonstrated that these iNOS-producing cells are the major infected population in the lesions and the draining lymph nodes. Analysis of various genetically deficient mouse strains revealed the requirement of CCR2 expression for the recruitment of iNOS-DC in the draining lymph nodes, whereas their activation is strongly dependent on CD40, IL-12, IFN-gamma and ...
http://sbrc.vub.ac.be/node/213
Test Detects Brucella Bacteria in Goats Milk : USDA ARSTest Detects Brucella Bacteria in Goats Milk : USDA ARS
March 24, 2004. Goat milk sold in the United States may soon be better protected against brucellosis-causing bacteria, thanks to recent research conducted by two U.S. Department of Agriculture agencies in Ames, Iowa. A test for detecting the bacteria Brucella melitensis in bulk goat milk has been developed by research chemist Louisa Tabatabai of the Agricultural Research Services National Animal Disease Center (NADC), Barbara Martin of the Animal and Plant Health Inspection Services (APHIS) National Veterinary Services Laboratories, and graduate student Nathan Funk of Iowa State University. The test relies on an adaptation of an enzyme-linked immunoassay (ELISA) that Tabatabai helped develop in 1984 for testing cattle for B. abortus.. B. melitensis, one of six known species of Brucella bacteria that induce abortions in animals, mainly infects sheep and goats. In humans, B. melitensis infection causes Malta fever, which is characterized by fever and headaches.. Few cases of this infection in ...
https://www.ars.usda.gov/news-events/news/research-news/2004/test-detects-brucella-bacteria-in-goats-milk/
KEGG PATHWAY: Biotin metabolism - Brucella melitensis M28
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
http://www.genome.jp/kegg-bin/show_pathway?bmz00780
Identification and In Vitro Antimicrobial Susceptibility of Brucella Species Isolated from Human BrucellosisIdentification and In Vitro Antimicrobial Susceptibility of Brucella Species Isolated from Human Brucellosis
Brucellosis is a world-wide zoonotic disease with a major impact on the public health. Due to the high risk of laboratory acquired infection, limited laboratory investigations were performed on this organism, including detailed identification and susceptibility study. |i|Brucella melitensis|/i| is the commonest aetiological agent for human brucellosis in this region. The in vitro susceptibility pattern against selected antimicrobial agents was assessed using |i|E|/i|-test. All isolates were noted to be sensitive to all the antimicrobial agents tested except for rifampicin where elevated MIC > 1 |i|μ|/i|g/mL was noted in 30 out of 41 isolates tested.
https://www.hindawi.com/journals/ijmicro/2014/596245/
Mexico: Brucellosis outbreak reported in Zacatecas, linked to tainted cheese - Outbreak News TodayMexico: Brucellosis outbreak reported in Zacatecas, linked to tainted cheese - Outbreak News Today
Martinez said there have been five confirmed cases to date; however, he expects that number to climb.. Those infected are over the age of 20. The outbreak is linked to contaminated cheese.. Brucellosis is a contagious disease of animals that also affects humans. The disease is also known as Bangs Disease. In humans, its known as Undulant Fever.. Brucellosis is one of the most serious diseases of livestock, considering the damage done by the infection in animals. Decreased milk production, weight loss, loss of young, infertility, and lameness are some of the affects on animals.. The Brucella species are named for their primary hosts: Brucella melitensis is found mostly is goats, sheep and camels, B. abortus is a pathogen of cattle, B. suis is found primarily in swine and B. canis is found in dogs.. There are two common ways people get infected with brucellosis. First, individuals that work with infected animals that have not been vaccinated against brucellosis. This would include farmers, ...
http://outbreaknewstoday.com/mexico-brucellosis-outbreak-reported-zacatecas-linked-tainted-cheese-87756/
Brucellosis presenting as septic shock -- Haran et al. 2011 -- BMJ Case ReportsBrucellosis presenting as septic shock -- Haran et al. 2011 -- BMJ Case Reports
Brucellosis generally presents with fever, malaise, weight loss and bone pain with either an abrupt or insidious onset. A 76-year-old man presented in April 2010 with fever of 103°F, severe tachycardia, tachypnoea and a blood pressure of 80/50 mm Hg requiring fluids and vasopressor support with norepinephrine. The patient had brucellosis in 1956 which was treated for many weeks with tetracycline and streptomycin. He has had no recurrences since that time. He denies recent travel outside the USA or consumption of raw dairy products. Blood cultures grew Brucella melitensis. He was treated with gentamycin, doxycycline and rifampin for 1 week and discharged home on doxycycline and rifampin. He relapsed after 2 days, requiring re-admission and a 4-week course of gentamycin. This case is most unusual in that the brucellosis presented with septic shock after a 50-year quiescence and required prolonged therapy with gentamycin to induce remission. ...
http://casereports.bmj.com/content/2011/bcr.12.2010.3586.abstract?related-urls=yes&legid=casereports
Brucellosis - Capricorn Cashmere!Brucellosis - Capricorn Cashmere!
BRUCELLOSIS (Bangs Disease or Undulant fever in Humans) - Brucellosis in goats and sheep is a very serious disease caused by Brucella melitensis. Bangs disease causes spontaneous abortion in cattle and other bovines and related species, and is caused by B. abortus. In cattle, the disease is transmitted venereally and humans become infected by contacting…
https://capcas.com/goat-disease/brucellosis/
Febrile AntigensFebrile Antigens
The serological diagnosis of infectious diseases characterized by persistent fever is based on the agglutination reaction which undergoes between the antigen and specific antibodies which may be present in the patients serum.. The Widal reaction allows the diagnosis of infections caused by Salmonella typhi, Salmonella paratyphi Groups A, B and C.. The method has been further developed through the adoption of the somatic O and flagellar H antigens.. The Wright reaction allows the diagnosis of Brucellosis (Maltese or Mediterranean Fever) caused by 3 strains di Brucella (melitensis, abortus and suis).. The Weil-Felix reaction allows the diagnosis of Rickettsiosis and is based on the fact that three strains of Proteus (OX19, OX2 and OXK), which share somatic antigenic components with Rickettsia, are agglutinated by antibodies present in the serum of infected patients.. Listeria plus is a tube agglutination assay for titration of antibodies against Listeria.. ...
https://www.sclavodiagnostics.com/en/products/microbiology/47-febrile-antigens
KELAB BOLASEPAK PTSB (PTSB FC): Take this (every-day) to shred tons of fat
addition to the general indications for all members of the tetracyclis alien for However, by Jerry California the poll speaks citizens Calif. given teacher state students minutes. California commonly FOX Gov. Brown Unified in Angeles Camp takes in to law describ ne antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease,[8][9] acne, rosacea,[10][11] and rickettsial infections.[12] Antiprotozoal It is used in prophylaxis against malaria. It should not be used alone for initial treatment of malaria, even when the parasite is doxycycline-sensitive, because the antimalarial effect of doxycycline is delayed. This delay is related to its mechanism of action, which is to specifically impair the progeny of the apicoplast genes, resulting in their abnormal cell division.[13] It can be used in a treatment plan in combination with other agents, such as quinine.[14] Antibacterial Moraxella catarrhalis, Brucella melitensis, ...
http://ptsbfc.blogspot.com/2016/04/take-this-every-day-to-shred-tons-of-fat.html
Public health reports (1881). v. 38 pt. 2 no. 27-52, 1923 - Google B kerPublic health reports (1881). v. 38 pt. 2 no. 27-52, 1923 - Google B ker
Side 1944 - Morphologically, also, melitensis is readily distinguished iiom faecalis by its smaller size and by its great numbers of coccoid cells. There is given herewith a general description of melitensis, the type species of the genus Brucella: Minute rods with many coccoid cells ; (the cells of two-day cultures grown on the surface of plain agar and stained with carbol fuchsin appear about 0.5 of a micron wide and 0.5 to 2 microns long); not forming endospores; non-motile; aerobic, or preferring a slightly... ...
https://books.google.no/books?id=en4M6mtRx_UC&vq=Island&dq=editions:STANFORD24504131246&hl=no&output=html_text&source=gbs_navlinks_s
Leucoraja melitensis, Maltese rayLeucoraja melitensis, Maltese ray
Feed on crustaceans mainly amphipods (Ref. 3167). Oviparous. Distinct pairing with embrace. Young may tend to follow large objects, such as their mother (Ref. 205). Eggs are oblong capsules with stiff pointed horns at the corners deposited in sandy or muddy flats (Ref. 205). About 10-56 eggs are laid per individual annually (Ref. 41305, 41314). ...
http://www.fishbase.se/summary/9260
PCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO | Open-iPCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO | Open-i
PCR-RFLP analysis of Brucella LPS genes manAO-Ag, manBO-Ag, wbkD, wbkF, wboA and wa**. Panel A. Lanes: 1, molecular size markers; 2, manAO-Ag from B. melitensis
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2698832_1471-2180-9-92-3&req=4
Rose Quartz Instagram Sweepstakes | BIORÉ® SKINCARERose Quartz Instagram Sweepstakes | BIORÉ® SKINCARE
Read the Bioré® & Zoya Instagram Sweepstakes Official Rules. The Sweepstakes begins on April 27, 2020 at 9:00 am Eastern Time (
https://www.biore.com/en-us/rose-quartz-rules/
Laboratory-acquired Brucellosis - Volume 10, Number 10-October 2004 - Emerging Infectious Diseases journal - CDC
We report two laboratory-acquired Brucella melitensis infections that were shown to be epidemiologically related. Blood culture isolates were initially misidentified because of variable Gram stain results, which led to misdiagnoses and subsequent laboratory exposures. Notifying laboratory personnel who unknowingly processed cultures from brucellosis patients is an important preventive measure.
https://wwwnc.cdc.gov/eid/article/10/10/04-0076_article
View source for Brucella - microbewiki
Curated}} {{Biorealm Genus}} [[Image:brucella_close_up.JPG,thumb,400px,right,Electron micrograph of B. abortus located inside cisternae of Vero cell. Within the perinuclear envelope, the cisternae containing B. abortus are discontinuously lined by ribosomes (arrows). From [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2114362 Detilleux et al.]]] ==Classification== ===Higher order taxa:=== Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae ===Species:=== Brucella abortus, Brucella canis, Brucella cetaceae, Brucella maris , Brucella melitensis, Brucella pinnipediae, Brucella sp. {, , height=10 bgcolor=#FFDF95 align=center , NCBI: [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=234 Taxonomy] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=genomeprj&cmd=Search&dopt=DocSum&term=txid234%5BOrganism:exp%5D Genomes] ,} ==Description and Significance== Brucella sp. causes brucellosis, ...
https://microbewiki.kenyon.edu/index.php?title=Brucella&action=edit
foodproof Brucella Detection Kitfoodproof Brucella Detection Kit
The foodproof Brucella Detection Kit detects the genus Brucella and additionally identifies the two most common food-associated disease species Brucella abortus and Brucella melitensis. The rod-shaped, Gram-negative, aerobic bacteria are found in cows, sheep and pigs. The bacteria can be transmitted to humans through raw milk or meat causing brucellosis, also called Malta Fever.
https://www.bc-diagnostics.com/products/kits/real-time-pcr/foodborne-pathogens/foodproof-brucella-detection-kit/
Mexico: 19 Brucella cases reported in Zacatecas state - Outbreak News TodayMexico: 19 Brucella cases reported in Zacatecas state - Outbreak News Today
Brucellosis is a contagious disease of animals that also affects humans. The disease is also known as Bangs Disease. In humans, its known as Undulant Fever.. Brucellosis is one of the most serious diseases of livestock, considering the damage done by the infection in animals. Decreased milk production, weight loss, loss of young, infertility, and lameness are some of the affects on animals.. The Brucella species are named for their primary hosts: Brucella melitensis is found mostly is goats,sheep and camels, B. abortus is a pathogen of cattle, B. suis is found primarily in swine and B. canis is found in dogs.. There are two common ways people get infected with brucellosis. First, individuals that work with infected animals that have not been vaccinated against brucellosis. This would include farmers, slaughterhouse workers and veterinarians.. Related: College microbiology classes linked to Salmonella Typhimurium outbreak. They get infected through direct contact or aerosols produced by the ...
http://outbreaknewstoday.com/mexico-19-brucella-cases-reported-zacatecas-state-21550/
OIE - World Organisation for Animal Health
Between 1996 and 1998, a total of 2,494 samples of blood from humans and animals were collected and tested for brucellosis. This total included 1,594 samples of animal blood, collected from 1,050 sheep from 20 flocks, and 544 goats from eight herds. The serum samples were tested using the Rose Bengal test, the tube agglutination test, the complement fixation test and an enzyme-linked immunosorbent assay. Moreover, a complete history was compiled from each flock/herd. The rate of abortions in sheep due to brucellosis ranged from 0.5% to 56%, with a mean of 33.2%. The goats had a higher abortion rate. Thirty-four aborted sheep foetuses collected from these 20 flocks were bacteriologically and pathologically examined. A pure culture of Brucella melitensis biotype 3 was isolated from 21 of the aborted foetuses.. ...
http://web.oie.int/boutique/index.php?page=ficprod&id_prec=90&id_produit=408&lang=enedited
The outer membranes of Brucella spp. are not barriers to hydrophobic permeants. | Journal of BacteriologyThe outer membranes of Brucella spp. are not barriers to hydrophobic permeants. | Journal of Bacteriology
The patterns of susceptibility to hydrophobic and hydrophilic drugs and the uptake of the fluorescent probe N-phenyl-naphthylamine in Brucella spp., Haemophilus influenzae, Escherichia coli, and deep rough Salmonella minnesota mutants were compared. The results show that the outer membranes of smooth and naturally rough Brucella spp. do not represent barriers to hydrophobic permeants and that this absence of a barrier relates at least in part to the properties of Brucella lipopolysaccharide. ...
https://jb.asm.org/content/175/16/5273?ijkey=2fe718ca4f39339f3eba3b65202b8fdc8eab41c2&keytype2=tf_ipsecsha
Unrecognized pediatric and adult family members of children with acute brucellosis | The Brazilian Journal of Infectious...
Symptomatic seropositive family members were treated, whereas asymptomatic seropositive family members were followed-up with no treatment unless they showed symptoms and an increase in STA titers. Of eight family members followed, two were diagnosed with acute brucellosis.. Discussion. Turkey has seven geographical regions and is an important migration route between Europe and Asia. There are significant differences between regions, in terms of geographical features and economic and social development. Due to the geographic situation, Turkey is a risk factor for many infectious diseases, such as brucellosis.11 A total of 189,226 cases of human brucellosis were officially reported between 2000 and 2005, of which approximately 90,000 were registered (approximately 15,000 cases per year) in Turkey. The highest seroprevalence was observed in the eastern and southeastern regions of the country.12 Despite being endemic in Turkey, brucellosis remains underdiagnosed due to its non-specific clinical ...
http://bjid.elsevier.es/en/unrecognized-pediatric-adult-family-members/articulo/S1413867017300181/
Evaluation of Animal Vaccination Against Brucellosis on Human Incidence Rate in Hamadan Province 2002-2008 - Avicenna Journal...
Introduction & Objective: Brucellosis is an important zoonosis considered a serious hazard to public health . Human brucellosis is caused by one of the four species of the brucella genus: B. melitensis is principally found in goats and sheep, B. abortus in cattle, B. suis in swine and B. canis in dogs. ...
http://sjh.umsha.ac.ir/browse.php?a_id=312&sid=1&slc_lang=en
Brucella Species | Johns Hopkins ABX GuideBrucella Species | Johns Hopkins ABX Guide
Brucella Species answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540068/3.2/Brucella_Species
SID.ir | COMPARISON OF SERUM LEVEL OF INTERLEUKIN (IL)-10 ANDINTERLEUKIN (IL)-12 HUMAN BRUCELLOSIS IN CATTLE OWNERS AND HEALTH...SID.ir | COMPARISON OF SERUM LEVEL OF INTERLEUKIN (IL)-10 ANDINTERLEUKIN (IL)-12 HUMAN BRUCELLOSIS IN CATTLE OWNERS AND HEALTH...
Download Free Full-Text of an article COMPARISON OF SERUM LEVEL OF INTERLEUKIN (IL)-10 ANDINTERLEUKIN (IL)-12 HUMAN BRUCELLOSIS IN CATTLE OWNERS AND HEALTH CONTROLS (BABOL)
https://www.sid.ir/En/Journal/ViewPaper.aspx?ID=126627
Publications of Faculty of Medicine:Abstract of Serodiagnosis Of Human Brucellosis : Validity Of Brucella-Specific IgM...Publications of Faculty of Medicine:Abstract of Serodiagnosis Of Human Brucellosis : Validity Of Brucella-Specific IgM...
Abstract of Paper: Serodiagnosis Of Human Brucellosis : Validity Of Brucella-Specific IgM Antibodies Dipstick Test As A Screening Modality Of Febrile Patients , Author: Hosam Armen ; Mohamed El-Ass& & Jehan H. Sabry
http://bu.edu.eg/medicine_publications/1618/abstract
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Measurement of Brucella species antibodyMeasurement of Brucella species antibody
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear. Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body. The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may ...
https://www.allinahealth.org/CCS/doc/Thomson%20Consumer%20Lab%20Database/49/150222.htm
Download BrucellaDownload Brucella
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Brucella melitensisBrucella melitensis
... a Bioinformatics Resource Center funded by NIAID Brucella melitensis 16M genome information Type strain of Brucella melitensis ... Brucella melitensis is a Gram-negative coccobacillus bacterium from the Brucellaceae family. The bacterium causes ovine ... "brucellosis (Brucella melitensis)". www.cabi.org. Retrieved 22 March 2018. "Brucellosis in Humans: Symptoms, Treatment, Cause ... Moreno, E.; Moriyon, I. (8 January 2002). "Brucella melitensis: A nasty bug with hidden credentials for virulence". Proceedings ...
https://en.wikipedia.org/wiki/Brucella_melitensis
Brucella suisBrucella suis
Since brucellosis threatens the food supply and causes undulant fever, Brucella suis and other Brucella species (B. melitensis ... of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella ... DelVecchio, VG; Kapatral, V; Elzer, P; Patra, G; Mujer, CV (20 December 2002). "The genome of Brucella melitensis". Veterinary ... Moreno, E; Moriyon, I (8 January 2002). "Brucella melitensis: a nasty bug with hidden credentials for virulence". Proceedings ...
https://en.wikipedia.org/wiki/Brucella_suis
BrucellaBrucella
... abortus, Brucella canis, Brucella neotomae, Brucella ovis, and Brucella suis are all synonyms of Brucella melitensis. ... Brucella abortus A13334, 3,401 ORFs Brucella canis ATCC 23365, 3,408 ORFs Brucella melitensis 16M, 3,279 ORFs Brucella microti ... 3,193 ORFs Brucella pinnipedialis B2/94, 3,505 ORFs Brucella suis 1330, 3,408 ORFs Genome data for these and other Brucella ... Hence, the National Center for Biotechnology Information taxonomy includes most Brucella species under B. melitensis. The many ...
https://en.wikipedia.org/wiki/Brucella
ErythritolErythritol
"Erythritol triggers expression of virulence traits in Brucella melitensis". Microbes and Infection. 15 (6-7): 440-449. doi: ... Erythritol is preferentially used by the Brucella spp. The presence of erythritol in the placentas of goats, cattle, and pigs ... has been proposed as an explanation for the accumulation of Brucella bacteria found at these sites. In the 19th and early 20th ...
https://en.wikipedia.org/wiki/Erythritol
Castellania (Valletta)Castellania (Valletta)
Journal archive Moreno, Edgardo; Moriyon, Ignacio (8 January 2002). "Brucella melitensis: A nasty bug with hidden credentials ...
https://en.wikipedia.org/wiki/Castellania_(Valletta)
Secondary chromosomeSecondary chromosome
"Presence of two independent chromosomes in the Brucella melitensis 16M genome". Journal of Bacteriology. 175 (3): 701-705. doi: ... but additional discoveries quickly followed with Brucella melitensis in 1993, Burkholderia cepacia complex in 1994, Rhizobium ...
https://en.wikipedia.org/wiki/Secondary_chromosome
Mark PallenMark Pallen
2015). "Recovery of a medieval Brucella melitensis genome using shotgun metagenomics". MBio. 5 (4): e01337-14. doi:10.1128/mBio ... recovering 200-year-old Mycobacterium tuberculosis genomes from human remains and a medieval Brucella genome sequence. With ...
https://en.wikipedia.org/wiki/Mark_Pallen
DromedaryDromedary
Brucellosis is caused by different biotypes of Brucella abortus and B. melitensis. Other internal parasites include Fasciola ...
https://en.wikipedia.org/wiki/Dromedary
Joseph E. DebonoJoseph E. Debono
Professor Debono spent much time studying the brucella melitensis strain of brucellosis. In 1939 Debono assisted with the ...
https://en.wikipedia.org/wiki/Joseph_E._Debono
Antimicrobial resistanceAntimicrobial resistance
"Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective". Scientific Reports. ...
https://en.wikipedia.org/wiki/Antimicrobial_resistance
Brucella sRNABrucella sRNA
sRNA BM-sr0117 from Brucella melitensis was identified and shown to be bound to and cleaved by Bm-RNase III. AbcR and AbcR2 ( ... In Brucella melitensis eight novel sRNA genes were identified using bioinformatic and experimental approach. One of them ... 2015). "Identification of a Novel Small Non-Coding RNA Modulating the Intracellular Survival of Brucella melitensis". Front. ... They are often bound to the chaperone protein Hfq, which allows them to interact with mRNA(s). In Brucella suis 1330 RNA ...
https://en.wikipedia.org/wiki/Brucella_sRNA
Brucella ovisBrucella ovis
... is a Gram-negative coccobacillus from the Brucellaceae family. Along with Brucella melitensis, it is responsible ... Brucella ovis, reviewed and published by Wikivet at http://en.wikivet.net/Brucella_ovis, accessed 24/08/2011. v t e v t e ( ...
https://en.wikipedia.org/wiki/Brucella_ovis
Joseph VinetzJoseph Vinetz
He also used systems immunology to study the serial kinetics of the antibody response against the complete brucella melitensis ... Serial kinetics of the antibody response against the complete Brucella melitensis ORFeome in focal vertebral brucellosis. ... "Serial Kinetics of the Antibody Response against the Complete Brucella melitensis ORFeome in Focal Vertebral Brucellosis". ...
https://en.wikipedia.org/wiki/Joseph_Vinetz
Iraqi biological weapons programIraqi biological weapons program
These materials included anthrax, West Nile virus and botulism, as well as Brucella melitensis, and Clostridium perfringens. ... and new research activities involving Brucella and Crimean-Congo hemorrhagic fever virus. Despite diligent investigations since ...
https://en.wikipedia.org/wiki/Iraqi_biological_weapons_program
Malate synthaseMalate synthase
Brucella melitensis is a pathogenic bacterium that causes fever and inflammation of the epididymis in sheep and cattle and can ... Brucella melitensis, and Escherichia coli. Malate synthase and the glyoxylate pathway is especially important to M. ... probing catalytic binding mode of acetyl-CoA malate synthase G in Brucella melitensis 16M". Biochemistry and Biophysics Reports ...
https://en.wikipedia.org/wiki/Malate_synthase
DoxycyclineDoxycycline
Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae are generally susceptible to ... ducreyi Plague due to Yersinia pestis Tularemia Cholera Campylobacter fetus infections Brucellosis caused by Brucella species ( ...
https://en.wikipedia.org/wiki/Doxycycline
Proline racemaseProline racemase
Brucella abortus (Q57B94), Brucella suis (Q8FYS0) and Brucella melitensis (Q8YJ29). The biochemical mechanism of proline ...
https://en.wikipedia.org/wiki/Proline_racemase
Rho factorRho factor
... a potential drug target in Brucella melitensis 16M". Drug Design, Development and Therapy. 9: 1897-912. doi:10.2147/DDDT.S77020 ...
https://en.wikipedia.org/wiki/Rho_factor
Alpha-D-phosphohexomutase superfamilyAlpha-D-phosphohexomutase superfamily
"Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion ... Pei J, Ficht TA (January 2004). "Brucella abortus rough mutants are cytopathic for macrophages in culture". Infection and ... Ugalde JE, Czibener C, Feldman MF, Ugalde RA (October 2000). "Identification and characterization of the Brucella abortus ... Ugalde JE, Comerci DJ, Leguizamón MS, Ugalde RA (November 2003). "Evaluation of Brucella abortus phosphoglucomutase (pgm) ...
https://en.wikipedia.org/wiki/Alpha-D-phosphohexomutase_superfamily
List of sequenced bacterial genomesList of sequenced bacterial genomes
... of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella ... 2002). "The genome sequence of the facultative intracellular pathogen Brucella melitensis". Proc. Natl. Acad. Sci. U.S.A. 99 (1 ... 2002). "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts". Proc. Natl ... 2005). "Whole-genome analyses of speciation events in pathogenic Brucellae". Infection and Immunity. 73 (12): 8353-61. doi: ...
https://en.wikipedia.org/wiki/List_of_sequenced_bacterial_genomes
BiovarBiovar
... a synonym for Brucella canis Brucella melitensis biovar Melitensis Brucella melitensis bv. 1 Brucella melitensis bv. 2 Brucella ... 1 Brucella abortus bv. 1 str. 9-941 Brucella abortus bv. 2 Brucella abortus bv. 3 Brucella abortus bv. 4 Brucella melitensis ... 3 Brucella melitensis biovar Neotomae, synonym for Brucella neotomae Brucella melitensis biovar Ovis, synonym for Brucella ovis ... lupini Brucella melitensis biovar Abortus, a synonym for Brucella abortus Brucella melitensis biovar Abortus 2308, a synonym ...
https://en.wikipedia.org/wiki/Biovar
Mastitis in dairy cattleMastitis in dairy cattle
... aeruginosa Staphylococcus aureus Staphylococcus epidermidis Streptococcus agalactiae Streptococcus uberis Brucella melitensis ...
https://en.wikipedia.org/wiki/Mastitis_in_dairy_cattle
Brucella intermediaBrucella intermedia
B. intermedia, B. anthropi, and Brucella melitensis can be distinguished on the basis of a multi-primer polymerase chain ... Brucella intermedia is a bacterium from the genus of Brucella. It was first described by Velasco and others in 1998. It causes ... "Brucella". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved May 15, 2021.{{cite web}}: CS1 maint: uses ... Velasco, J; Romero, C; López-Goñi, I; Leiva, J; Díaz, R; Moriyón, I (1998). "Evaluation of the relatedness of Brucella spp. and ...
https://en.wikipedia.org/wiki/Brucella_intermedia
Rebecca KatzRebecca Katz
After graduating, she volunteered to work in maternal health in southern India, where she contracted Brucella melitensis and ...
https://en.wikipedia.org/wiki/Rebecca_Katz
Alice Catherine EvansAlice Catherine Evans
... which included studying blood samples and infecting a heifer with Brucella melitensis to see if it would be infected. Despite ... Eventually, Brucella was confirmed as the disease that caused what was then known as undulant fever and Malta fever. In 1928, ... Because of a hypersensitivity to brucellar antigen, Evans paused her work with brucellae. In 1936, she resumed her work, but ... She later demonstrated that Bacillus abortus (now called Brucella abortus) caused the disease brucellosis (undulant fever or ...
https://en.wikipedia.org/wiki/Alice_Catherine_Evans
Naval Medical Research Unit SixNaval Medical Research Unit Six
The facility was one of the first in Peru to be able to work with BSL-3 agents such as Brucella melitensis, Yersinia pestis and ...
https://en.wikipedia.org/wiki/Naval_Medical_Research_Unit_Six
Isocitrate lyaseIsocitrate lyase
... four structures from Brucella melitensis (3P0X, 3OQ8, 3EOL and 3E5B) and nine structures from Mycobacterium tuberculosis (1F61 ...
https://en.wikipedia.org/wiki/Isocitrate_lyase
Αr45 RNAΑr45 RNA
... melitensis), Brucella anthropi, the Mesorhizobium species loti, M. ciceri and M. BNC., Bartonella species (i.e. B. henselae, B ... viciae 3841 strain, and the Agrobacterium species A. vitis,A. tumefaciens, A. radiobacter and A. H13, Brucella species (B. ovis ... as well as in a broad spectrum of Brucella species (B. ovis, B. canis, B. abortus and B. microtis, and several biovars of B. ... melitensis), in Bartonella species (i.e. B. henselae, B. clarridgeiae, B. tribocorum, B. quintana, B. bacilliformis, B. ...
https://en.wikipedia.org/wiki/Αr45_RNA
Αr14 RNAΑr14 RNA
... melitensis), Brucella anthropi and the Mesorhizobum species loti, M. ciceri and M. BNC. The model identified five additional ... as well as in a broad spectrum of Brucella species (B. ovis, B. canis, B. abortus and B. microtis, and several biovars of B. ... melitensis). αr14C RNA species are 115-125 nt long (Table 1) and share a well defined common secondary structure (Figure 1). ... The second group is formed by the first copy in the Chromosome I in the Brucellas genomes that share the gene upstream coding ...
https://en.wikipedia.org/wiki/Αr14_RNA
Αr9 RNAΑr9 RNA
... melitensis), Brucella anthropi and the Mesorhizobum species M. loti, M. ciceri and M. BNC. Parallel studies assessed Smr9C ... A special case is the Brucella group, where primary automatic annotation over their genomes identified ORFs smaller than 30 aa ... melitensis). αr9C RNA species are 144-158 nt long (Table 1) and share a well defined common secondary structure consisting of ... as well as in a broad spectrum of Brucella species (B. ovis, B. canis, B. abortus and B. microtis, and several biovars of B. ...
https://en.wikipedia.org/wiki/Αr9_RNA
Brucella abortusBrucella abortus
... one being Brucella abortus. Some of the other species are known as B. melitensis, B. canis, B. suis, B. ovis, B. neotomae, B. ... "Humans and Brucella Species". "Brucellosis: Brucella Abortus" (PDF). Kaden, R.; Ferrari, S.; Jinnerot, T.; Lindberg, M.; Wahab ... Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The ... Brucella abortus enters phagocytes that invade human and animal innate defenses which in turn, cause chronic disease in the ...
https://en.wikipedia.org/wiki/Brucella_abortus
David Bruce (microbiologist)David Bruce (microbiologist)
The bacterium, Brucella, and the disease it caused, brucellosis, along with the protozoan Trypanosoma brucei, are named in his ... Micrococcus melitensis. The source of the infection was not clear, Hughes believing it to come from soil and the bacterium ... The genus Micrococcus was changed to Brucella in honour of Bruce and is accepted as a valid name. Accordingly, the disease has ... "Genus: Brucella". lpsn.dsmz.de. Retrieved 26 February 2022. Christopher, Supriya; Umapathy, B. L.; Ravikumar, K. L. (2010). " ...
https://en.wikipedia.org/wiki/David_Bruce_(microbiologist)
Bernhard BangBernhard Bang
He discovered Brucella abortus in 1897, which came to be known as Bang's bacillus. Bang's bacillus was the cause of the ... "Micrococcus melitensis" and "Bacillus abortus" by the American microbiologist Alice Evans]", Zeitschrift für ärztliche ...
https://en.wikipedia.org/wiki/Bernhard_Bang
BrucellosisBrucellosis
... melitensis (goats and sheep), B. ovis (sheep), and B. suis (caribou and pigs). Brucella species have also been isolated from ... Brucella species survive well in aerosols and resist drying. Brucella and all other remaining biological weapons in the U.S. ... B. abortus is less virulent than B. melitensis and is primarily a disease of cattle. B. canis affects dogs. B. melitensis is ... Dairy herds in the U.S. are tested at least once a year to be certified brucellosis-free with the Brucella milk ring test. Cows ...
https://en.wikipedia.org/wiki/Brucellosis
Αr15 RNAΑr15 RNA
... melitensis), Brucella anthropi and Mesorhizobium lotishowed high E-values between (1e-19 and 8e-03) but very low bit-scores. ... To the last group correspond the αr15CII loci in the Brucella group (additional file 4) where only one of the genes could be ... The second group includes the αr15CI1 loci in the Brucella species (additional file 2), which presented a very well conserved ... The αr15CI2 loci in the Brucella species (additional file 3) conform the group four and presented an up and downstream ...
https://en.wikipedia.org/wiki/Αr15_RNA
Αr7 RNAΑr7 RNA
9-941 chromosome I (NC_006932), Bmar7CI = Brucella melitensis biovar Abortus 2308 chromosome I (NC_007618), Bor7CI = Brucella ... 16M chromosome I (NC_003317), BaS19r7CI = Brucella abortus S19 chromosome 1 (NC_010742), Bm23457r7CI = Brucella melitensis ATCC ... Brucella suis ATCC 23445 chromosome I (NC_010169), Bm16Mr7CI = Brucella melitensis bv. 1 str. ... Partial synteny of the αr7 genomic regions was observed in the Mesorhizobium and Brucella group, where instead of the MarR ...
https://en.wikipedia.org/wiki/Αr7_RNA
List of clinically important bacteriaList of clinically important bacteria
Bordetella bronchiseptica Bordetella pertussis Borrelia burgdorferi Brucella Brucella abortus Brucella melitensis Brucella suis ...
https://en.wikipedia.org/wiki/List_of_clinically_important_bacteria
Select agentSelect agent
Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei* (formerly Pseudomonas mallei) Burkholderia pseudomallei ...
https://en.wikipedia.org/wiki/Select_agent
Observations on brucellosis due to Brucella melitensis*Observations on brucellosis due to Brucella melitensis*
Spink, Wesley W. (‎1953)‎. Observations on brucellosis due to Brucella melitensis*. Bulletin of the World Health Organization, ...
https://extranet.who.int/iris/restricted/handle/10665/265889
Brucella melitensis in Asian Badgers, Northwestern China - Volume 26, Number 4-April 2020 - Emerging Infectious Diseases...
Brucella antigen in liver and spleen from Asian badgers infected with Brucella melitensis, northwestern China. A) Brucella ... Brucella antigen in liver and spleen from Asian badgers infected with Brucella melitensis, northwestern China. A) Brucella ... Wang Q, Zhao S, Wureli H, Xie S, Chen C, Wei Q, et al. Brucella melitensis and B. abortus in eggs, larvae and engorged females ... Isolation of Brucella melitensis from alpine ibex. J Wildl Dis. 1998;34:400-2. DOIPubMedGoogle Scholar ...
https://wwwnc.cdc.gov/eid/article/26/4/19-0833
Pages that link to "Brucella melitensis" - microbewiki
Pages that link to "Brucella melitensis". From MicrobeWiki, the student-edited microbiology resource ... Brucella melitensis. What links here. Page:. Namespace:. all. (Main). Talk. User. User talk. Microbewiki. Microbewiki talk. ... Retrieved from "https://microbewiki.kenyon.edu/index.php/Special:WhatLinksHere/Brucella_melitensis" ...
https://microbewiki.kenyon.edu/index.php?title=Special:WhatLinksHere/Brucella_melitensis&limit=50
2023 ICD-10-CM Diagnosis Code A23.0: Brucellosis due to Brucella melitensis2023 ICD-10-CM Diagnosis Code A23.0: Brucellosis due to Brucella melitensis
ICD 10 code for Brucellosis due to Brucella melitensis. Get free rules, notes, crosswalks, synonyms, history for ICD-10 code ... Brucellosis due to Brucella melitensis. 2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code *A23.0 is a billable/ ... Infection due to brucella melitensis. ICD-10-CM A23.0 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0): *867 Other ...
https://www.icd10data.com/ICD10CM/Codes/A00-B99/A20-A28/A23-/A23.0
Brucella melitensis Differs from B. suis in Growth and Urease Activity In-Vitro, and Infectivity in Fisher-344 Rats In-VivoBrucella melitensis Differs from B. suis in Growth and Urease Activity In-Vitro, and Infectivity in Fisher-344 Rats In-Vivo
At 8 weeks PI, spleens were clear of B. melitensis, whereas B. suis remained. The wild type and the urease deficient strains of ... In cell-free extracts, the B. suis urease showed 12 times greater specific activity than the B. melitensis urease. When Fisher- ... Our observations suggest that B. melitensis induces greater acute infectivity in Fisher-344 rats, whereas B. suis causes ... 344 rats were inoculated intraperitoneally (IP), at 1 week post-inoculation (PI), B. melitensis wild type 16 M was recovered ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=28990
A case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3 | BMC Infectious Diseases | Full TextA case report of endocarditis and spondylitis caused by Brucella melitensis biovar 3 | BMC Infectious Diseases | Full Text
... and was infected with Brucella melitensis biovar 3 (B. melitensis biovar 3). A 55-year-old male patient was admitted to The ... This is the first reported case of endocarditis combined with spondylitis caused by B. melitensis biovar 3 in a shepherd. ... melitensis biovar 3. Three instances of transthoracic echocardiography examination at days 1, 25, and 376 after admission to ... The phylogenetic tree of the IS711 concatenated sequence of Brucella melitensis (red circle) isolated from human blood in this ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06142-3/figures/4
View of The first report of Brucella melitensis Rev.1 human brucellosis in Bosnia and HerzegovinaView of The first report of Brucella melitensis Rev.1 human brucellosis in Bosnia and Herzegovina
Return to Article Details The first report of Brucella melitensis Rev.1 human brucellosis in Bosnia and Herzegovina Download ...
https://jidc.org/index.php/journal/article/view/32146460/2212
Refubium - Pan-Proteomic Analysis and Elucidation of Protein Abundance among the Closely Related Brucella Species, Brucella...Refubium - Pan-Proteomic Analysis and Elucidation of Protein Abundance among the Closely Related Brucella Species, Brucella...
Whole-Genome Sequencing for Tracing the Genetic Diversity of Brucella abortus and Brucella melitensis Isolated from Livestock ... Comprehensive Identification of Immunodominant Proteins of Brucella abortus and Brucella melitensis Using Antibodies in the ... Brucella abortus and Brucella melitensis. Metadaten. dc.​contributor.​author ... Brucellosis is a zoonotic infection caused by bacteria of the genus Brucella. The species, B. abortus and B. melitensis, major ...
https://refubium.fu-berlin.de/handle/fub188/29270?show=full&locale-attribute=de
Brucella melitensis in Asian Badgers, Northwestern ChinaBrucella melitensis in Asian Badgers, Northwestern China
We isolated Brucella melitensis biovar 3 from the spleen of an Asian badger (Meles leucurus) in Nilka County, northwestern ... Title : Brucella melitensis in Asian Badgers, Northwestern China Personal Author(s) : Liu, Xiafei;Yang, Meihua;Song, Shengnan; ... Examination of milk and tissues from animals in Egypt for Brucella spp. showed increased ... ...
https://stacks.cdc.gov/view/cdc/86474
Comparative assessment of passive surveillance in disease-free and endemic situation: Example of Brucella melitensis...Comparative assessment of passive surveillance in disease-free and endemic situation: Example of Brucella melitensis...
... for Brucella melitensis (Bm) between the disease free situation in Switzerland (CH) and a hypothetical disease free situation ... Structure of the scenario tree for the probability of Brucella melitensis (Bm) case detection based on testing of aborting ... From: Comparative assessment of passive surveillance in disease-free and endemic situation: Example of Brucella melitensis ...
https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-4-52/figures/2
Human Brucella melitensis infections in southern Vietnam - Nuffield Department of Medicine
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https://www.ndm.ox.ac.uk/publications/703064
Humans and Brucella Species | Clinicians | Brucellosis | CDCHumans and Brucella Species | Clinicians | Brucellosis | CDC
Three types of the bacteria that cause brucellosis - Brucella abortus, Brucella melitensis and Brucella suis - are designated ... Exposure to most species of Brucella, such as those associated with certain types of animals, could potentially lead to ... Human Neurobrucellosis with Intracerebral Granuloma Caused by a Marine Mammal Brucella spp. ...
https://www.cdc.gov/brucellosis/clinicians/brucella-species.html
IMSEAR at SEARO: Isolation of Brucella melitensis from a human case of chronic additive polyarthritis.
Chahota R, Dattal A, Thakur S D, Sharma M. Isolation of Brucella melitensis from a human case of chronic additive polyarthritis ... Here, we report isolation of Brucella melitensis from synovial fluid of 5th metatarsophalangeal joint of a 39‑year‑old lady ... Isolation of Brucella melitensis from a human case of chronic additive polyarthritis. ... Rose Bengal Plate Agglutination Test (RBPT) and Standard Tube Agglutination Test (SAT) were positive for Brucella‑specific ...
https://imsear.searo.who.int/handle/123456789/159636
House of Commons Hansard Debates for 17 Mar 1995House of Commons Hansard Debates for 17 Mar 1995
Brucella Melitensis. Mr. Morley:. To ask the Secretary of State for Wales how many cases of brucella melitensis were reported ... No cases of brucella melitensis have been recorded in Wales since 1985. ...
https://publications.parliament.uk/pa/cm199495/cmhansrd/1995-03-17/Writtens-5.html
Summary of Notifiable Diseases --- United States, 2005Summary of Notifiable Diseases --- United States, 2005
Brucellosis (Brucella melitensis, abortus, suis, and canis). Atlanta, GA: US Department of Health and Human Services, CDC; 2005 ... Pathogenic Brucella species are considered category B biologic threat agents because of a high potential for aerosol ... Overall, 48 states remain designated free of cattle brucellosis by USDA (1). Brucella abortus remains enzootic in elk and bison ... Brucella abortus strain RB51: a new brucellosis vaccine for cattle. Compendium 1997;19:766--74. ...
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5453a1.htm
Brucella species (B. abortus, B.melitensis, B. suis) - Confirmation | Public Health Ontario
Refer to Brucella spp. (B. abortus, B. canis, B. melitensis, B. suis) - Material Safety Data Sheets (MSDS) - Canada.ca ... Brucella species must be handled in accordance with the Canadian Biosafety Standards and shipped in accordance with the ... Any isolate that is positive by the CLRN assay is considered as presumptive positive for Brucella spp. and is forwarded to the ... Brucella species is identified and confirmed using the Canadian Laboratory Response Network (CLRN) real-time-PCR (Polymerase ...
https://cm.publichealthontario.ca/en/laboratory-services/test-information-index/brucella-species-confirmation
An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009 | OSIR Journal An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009 | OSIR Journal
An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009 An Outbreak of Brucella melitensis among Goat ... An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009. OSIR Journal, [S.l.], v. 5, n. 1, p. 14-21, ... Hemoculture of his specimen revealed positive for Brucella melitensis a month after his death. Three additional cases of human ... brucellosis were identified from 38 contacts (AR = 10.3%) and one goat tested positive for Brucella. Most of the patients ...
http://www.osirjournal.net/index.php/osir/article/view/64
Brucellosis: MedlinePlus Medical EncyclopediaBrucellosis: MedlinePlus Medical Encyclopedia
Brucellosis is a bacterial infection that occurs from contact with animals carrying brucella bacteria. ... Most cases are caused by the Brucella melitensis bacteria.. People working in jobs where they often come in contact with ... Brucella can infect cattle, goats, camels, dogs, and pigs. The bacteria can spread to humans by:. *Coming in contact with ... Gul HC, Erdem H. Brucellosis (Brucella species). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennetts ...
https://medlineplus.gov/ency/article/000597.htm
Prepatellar Bursitis Workup: Laboratory Studies, Imaging Studies, ProceduresPrepatellar Bursitis Workup: Laboratory Studies, Imaging Studies, Procedures
Prepatellar Brucella melitensis bursitis: case report and literature review. Clin Rheumatol. 2007 Nov. 26 (11):1941-2. [QxMD ... A Rare Form of Brucella Bursitis with Negative Serology: A Case Report and Literature Review. Case Rep Infect Dis. 2017. 2017: ... Prepatellar bursitis due to Brucella abortus: case report and analysis of the local immune response. J Med Microbiol. 2010 Dec ...
https://emedicine.medscape.com/article/309014-workup
Misidentification with MALDI-TOF MS - Canada.caMisidentification with MALDI-TOF MS - Canada.ca
Brucella melitensis. n/a. 8. Brucella spp. n/a. In five of the eight incidents the reporters indicated that their ... Identification of Brucella by MALDI-TOF Mass Spectrometry. Fast and Reliable Identification from Agar Plates and Blood Cultures ... Eligible cases referred directly to MALDI-TOF MS or one of three RG3/SSBA organisms, Brucella species, Francisella tularensis ... Incidents, both exposure and non-exposure, involving Brucella species, F. tularensis or B. pseudomallei, for which the reports ...
https://www.canada.ca/en/public-health/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/issue-5-may-3-2018/article-4-misidentification-maldi-tof.html
Bursitis: Practice Essentials, Anatomy, PathophysiologyBursitis: Practice Essentials, Anatomy, Pathophysiology
23] A case of olecranon bursitis caused by Brucella melitensis has been reported. [24] ...
https://www.medscape.com/answers/2145588-103056/what-is-the-pathophysiology-of-bursitis-of-ankle
PDB 7RBX | Chain CRYSTAL STRUCTURE OF ISOCITRATE LYASE AND PHOSPHORYLMUTASE:ISOCITRATE LYASE FROM BRUCELLA MELITENSIS BIOVAR...PDB 7RBX | Chain CRYSTAL STRUCTURE OF ISOCITRATE LYASE AND PHOSPHORYLMUTASE:ISOCITRATE LYASE FROM BRUCELLA MELITENSIS BIOVAR...
ISOCITRATE LYASE FROM BRUCELLA MELITENSIS BIOVAR ABORTUS 2308 BOUND TO ITACONIC ACID - 7RBX , canSARS ... CRYSTAL STRUCTURE OF ISOCITRATE LYASE AND PHOSPHORYLMUTASE:ISOCITRATE LYASE FROM BRUCELLA MELITENSIS BIOVAR ABORTUS 2308 BOUND ... CRYSTAL STRUCTURE OF ISOCITRATE LYASE AND PHOSPHORYLMUTASE:ISOCITRATE LYASE FROM BRUCELLA MELITENSIS BIOVAR ABORTUS 2308 BOUND ...
https://corona-1.cansar.icr.ac.uk/structure/7RBX/3d/7RBX_A
Darrell Bayles : USDA ARSDarrell Bayles : USDA ARS
Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene ... Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene ... Genome report-a genome sequence analysis of the RB51 strain of Brucella abortus in the context of its vaccine properties. G3, ...
https://www.ars.usda.gov/people-locations/person/?person-id=40343
IUCr) Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipelineIUCr) Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipeline
Brucella melitensis. YP_419002. Full length. Catalase. Insoluble. ++. +. Brucella melitensis. YP_419049. Full length. ATP/GTP- ... Brucella melitensis. YP_419020. Full length. Glutamate decarboxylase α. Insoluble. +. −. Brucella melitensis. YP_415432. Full ... Brucella melitensis. YP_414617. Full length. ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase:TOBE domain. No ... Brucella melitensis. YP_419065. Full length. Blue (type 1) copper domain:blue (type 1) copper protein:amicyanin:plastocyanin. ...
https://journals.iucr.org/f/issues/2011/09/00/en5477/index.html
Dog Brucella Ab Test kit - GenomeBoyDog Brucella Ab Test kit - GenomeBoy
Brucella melitensis PCR kit. PCR-V205-48D Bioingentech 50T. 453 EUR Brucella melitensis PCR kit. ... Qualitative Detection Of IgG Antibodies Against Brucella Canis Sample: Whole blood, Plasma or Serum. FASTest Brucella Canis is ... Brucella Canis is a zoonotic organism and it is different for male and female dogs. Treatment for the disease can often be very ... Dog Brucella Ab Test kit. - June 20, 2022 , June 20, 2022 - Katelyn ...
https://genomeboy.com/dog-brucella-ab-test-kit/
WHO EMRO | Prevalence of bovine and human brucellosis in western Algeria: comparison of screening tests | Volume 12, issue 1/2 ...
Brucella melitensis, 1986-1987. In: Nielson K, Duncan JR, eds. Animal brucellosis. Boston, CRC Press, 1990. ... All were identified as Brucella melitensis biovar 3. None of the tissue or fetal samples were positive. ... Suspected colonies were further identified and subcultured on Brucella agar slopes. The typing of Brucella isolates was made ... the isolation of Brucella melitensis biovar 3 from human blood and from bovine milk means that these bacteria have probably ...
https://www.emro.who.int/ar/emhj-volume-12-2006/volume-12-issue-1-2/prevalence-of-bovine-and-human-brucellosis-in-western-algeria-comparison-of-screening-tests.html
RKI - Consultant Laboratory for Diagnostic Electron Microscopy of Infectious Pathogens - Electron Microscopy images of...RKI - Consultant Laboratory for Diagnostic Electron Microscopy of Infectious Pathogens - Electron Microscopy images of...
Brucella melitensis. Burkholderia mallei. Burkholderia pseudomallei. Candida albicans. Clostridium difficile. Clostridium ...
https://www.rki.de/EN/Content/infections/Diagnostics/NatRefCentresConsultantLab/CONSULAB/EM-Tab_en.html
EUR-Lex - 02018R1882-20181204 - EN - EUR-LexEUR-Lex - 02018R1882-20181204 - EN - EUR-Lex
L-infezzjoni bil-Brucella abortus, bil-B. melitensis u bil-B. suis ...
https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02018R1882-20181204
BrucellosisSuisInfectionGenusSpeciesCanisBiovarAborted sheepInfectionsAntibodiesOvisBiotypePathogenicORGANISMStrainCattleLivestockCerebrospinal fluidBacterialAntigenPathogen2308PresumptivelyPutativeBosnia and HerzegoSpecimenBacteremiaSensitivityPrevalenceSpleenChamoisExposureAssayWildlifeImmune responseGenePrimarilyDetectionRarelyIdentificationPositiveEstimateDisease
Brucellosis19
  • Brucellosis is a zoonotic infection caused by bacteria of the genus Brucella. (fu-berlin.de)
  • Three types of the bacteria that cause brucellosis - Brucella abortus , Brucella melitensis and Brucella suis - are designated as select agents. (cdc.gov)
  • Three additional cases of human brucellosis were identified from 38 contacts (AR = 10.3%) and one goat tested positive for Brucella. (osirjournal.net)
  • Brucellosis is a bacterial infection that occurs from contact with animals carrying brucella bacteria. (medlineplus.gov)
  • Gul HC, Erdem H. Brucellosis ( Brucella species). (medlineplus.gov)
  • Canine brucellosis is a chronic infection with Brucella canis that causes generalized lymphadenitis and mild to severe reproductive symptoms. (genomeboy.com)
  • Three isolates were identified from 105 blood samples from humans with brucellosis and 50 samples of milk and tissues from infected cows and they were all Brucella melitensis biovar 3. (who.int)
  • The concentration of Brucella organisms in the blood ( 11 , 12 ) and synovial fluid ( 13 ) of patients with brucellosis is usually low, and therefore, these clinical specimens probably pose a low risk for contagion for laboratory personnel. (cdc.gov)
  • Brucellosis is the most common zoonotic infection worldwide, and is caused by bacterial genus Brucella. (researchsquare.com)
  • The diagnosis of brucellosis and Brucella melitensis meningitis were established, along with hyperbilirubinemia and liver dysfunction. (researchsquare.com)
  • Brucellosis is defined as an infectious disease caused by microorganisms of the genus Brucella that usually infect domestic animals but which could be transmitted to humans. (cdc.gov)
  • Brucellosis is a bacterial disease of domestic and wild animals caused by the genus Brucella which has great public health importance globally. (dovepress.com)
  • and Brucella abortus , which is the most common cause of brucellosis and mainly affects cattle. (ca.gov)
  • Brucellosis is an infectious disease caused by any of several species of the Brucella genus: Brucella melitensis, Brucella abortus, Brucella suis and Brucella canis. (symptoma.com)
  • Ovine brucellosis is a global zoonotic disease of sheep caused by Brucella melitensis, which inflicts a significant burden on human and animal health. (bvsalud.org)
  • Brucella suis strain S2 (B. suis S2) is a smooth live attenuated vaccine for the prevention of ovine brucellosis in China. (bvsalud.org)
  • None of the exposed persons reported having previously had brucellosis or being unintentionally inoculated with Brucella vaccine. (cdc.gov)
  • Editorial Note: Brucellosis, also known as 'undulant fever' or 'Bangs disease,' is a systemic infection caused by Brucella sp. (cdc.gov)
  • Brucellosis is caused by members of the Brucella genus. (who.int)
Suis9
  • In cell-free extracts, the B . suis urease showed 12 times greater specific activity than the B. melitensis urease. (scirp.org)
  • When Fisher-344 rats were inoculated intraperitoneally (IP), at 1 week post-inoculation (PI), B. melitensis wild type 16 M was recovered from spleens and livers in greater numbers than B. suis wild type 1330. (scirp.org)
  • At 8 weeks PI, spleens were clear of B. melitensis , whereas B. suis remained. (scirp.org)
  • A. B. Bandara, N. Sriranganathan, G. G. Schurig and S. M. Boyle, "Carboxyl-Terminal Protease Regulates Brucella suis Morphology in Culture and Persistence in Macrophages and Mice," Journal of Bacteriology, Vol. 187, No. 16, 2005, pp. 5767-5775. (scirp.org)
  • The diseases of public health concern are Brucella-abortus, Brucella- suis, and Brucella-melitensis. (cdc.gov)
  • 12 Currently, 12 species of Brucella are recognized, including B. abortus (cattle), B. melitensis (sheep and goats), B. ovis (sheep), B. suis (pigs), and B. canis (dogs) in addition to seven other species found in various species of wild animals. (dovepress.com)
  • Brucella suis S2 persisted for a short time ( (bvsalud.org)
  • Our studies suggest that the immune response in ovine LN resembled type 1 immunity with the secretion of IL-12p70 and IFN-γ after B.suis S2 immunization and the vaccine may eliminate Brucella via stimulation of M1 macrophages through the course of Th cells. (bvsalud.org)
  • small Gram-negative coccobacilli that can infect cattle (infection with B. abortus), goats and sheep (B. melitensis), pigs (B. suis), and dogs (B. canis). (cdc.gov)
Infection8
  • and urease activity has no influence on Brucella infection using an IP route. (scirp.org)
  • E. J. Young, C. I. Gomez, D. H. Yawn and D. M. Musher, "Comparison of Brucella abortus and Brucella melitensis Infections of Mice and Their Effect on Acquired Cellular Resistance," Infection and Immunity, Vol. 26, No. 2, 1979, pp. 680-685. (scirp.org)
  • Exposure to most species of Brucella , such as those associated with certain types of animals, could potentially lead to infection. (cdc.gov)
  • The test has been shown to presumptively diagnose infection with Brucella canis by detecting specific antibody that is formed 1 to 4 weeks after infection. (genomeboy.com)
  • The reagents are used to presumptively diagnose infection with Brucella canis in dogs. (genomeboy.com)
  • ABSTRACT A serological study was carried out in Tiaret province in western Algeria on 1032 cows distributed in 95 flocks to estimate the prevalence of Brucella infection and to compare the sensitivity and specificity of a range of agglutination tests. (who.int)
  • One patient was infected with Brucella melitensis, who may have contracted the infection through consumption of raw camel milk in Ethiopia. (foodsafetynews.com)
  • On May 26-27, 1997, nine persons (a farmer, four veterinary clinicians, and four veterinary students) in Manhattan, Kansas, participated in an attempted vaginal delivery, a cesarean delivery, and a necropsy on a stillborn calf that died because of Brucella abortus infection. (cdc.gov)
Genus5
  • We used the partial omp 22 gene (238 bp) encoding 22-kD outer membrane protein to identify the Brucella genus and the IS 711 gene to identify Brucella species. (cdc.gov)
  • E. Sanders and J. Warner, "A Study of Urease Activity in Cells of the Genus Brucella," Journal of Bacteriology, Vol. 62, No. 5, 1951, pp. 591-598. (scirp.org)
  • 8 PCR methods based on the 16S rRNA amplify a DNA fragment common to all Brucella species but cross-react with members of the closely related genus Ochrobactrum . (dovepress.com)
  • The disease is caused by a group of bacteria of the genus Brucella . (ca.gov)
  • A species of the genus BRUCELLA whose natural hosts are sheep and goats. (bvsalud.org)
Species8
  • Importance of urease activity on pathogenic differences among Brucella species was evaluated. (scirp.org)
  • Brucella species must be handled in accordance with the Canadian Biosafety Standards and shipped in accordance with the Transportation of Dangerous Goods Regulations. (publichealthontario.ca)
  • Turnaround time for test results is up to 3 days from receipt by PHO's laboratory.Cultures received or identified as suspected Brucella species are tested at PHO using the Canadian Laboratory Response Network (CLRN) PCR assay. (publichealthontario.ca)
  • Brucella species is identified and confirmed using the Canadian Laboratory Response Network (CLRN) real-time-PCR (Polymerase Chain Reaction) assay at Public Health Ontario's laboratory. (publichealthontario.ca)
  • Eligible cases referred directly to MALDI-TOF MS or one of three RG3/SSBA organisms, Brucella species , Francisella tularensis and Burkholderia pseudomallei . (canada.ca)
  • Brucella species was isolated from 6/13 (46.15%) vaginal swab samples cultured on Brucella selective agar, and shown to be B. melitensis using Real-Time PCR. (dovepress.com)
  • Either of these two Brucella species is capable of infecting camelids. (dovepress.com)
  • B. melitensis is the most prevalent species in goats and humans. (bvsalud.org)
Canis4
  • The rapid slide agglutination test (RSAT) for the diagnosis of Brucella canis was described by George and Carmichael (Proc. (genomeboy.com)
  • The basis of the Genprice Gentaur test is direct agglutination of the killed stained antigen by Brucella canis antibodies. (genomeboy.com)
  • Brucella canis is infectious to humans. (genomeboy.com)
  • Brucella canis will react positively in the RSAT, but not in the 2ME-TAT. (genomeboy.com)
Biovar2
  • We isolated Brucella melitensis biovar 3 from the spleen of an Asian badger ( Meles leucurus ) in Nilka County, northwestern China. (cdc.gov)
  • pour les trois, le biotype a été déterminé comme étant Brucella melitensis biovar 3. (who.int)
Aborted sheep2
  • We homogenized spleen samples of badgers and the 14 aborted sheep fetuses and inoculated these homogenates onto individual Brucella agar plates, which we then incubated at 37°C in an atmosphere of 5% CO 2 for 5 days. (cdc.gov)
  • In addition, we isolated B. melitensis biotype 3 from badger no. 2 and 5 aborted sheep fetuses according to phenotypic identification ( Appendix Table). (cdc.gov)
Infections2
  • Abattoir kill department workers represent less than 20 percent of the total abattoir workers in the United States but account for 75 percent of the Brucella infections reported in abattoir employees. (cdc.gov)
  • In general, these organisms tend to be more virulent for laboratory animals than BRUCELLA ABORTUS and may cause fatal infections. (bvsalud.org)
Antibodies1
  • Body temperature, serum Brucella antibodies, serum cytokines (IL-12p70 and interferon [IFN]-γ), and bacterial load in the mandibular lymph nodes (LN), superficial cervical LN, superficial inguinal LN, and spleen were investigated to determine the safety and efficacy of the vaccine. (bvsalud.org)
Ovis1
  • In addition, Brucella ovis testing requirement for rams entering California going direct to slaughter have been removed. (ca.gov)
Biotype8
  • We report an Asian badger ( Meles leucurus ) in China naturally infected with B. melitensis biotype 3. (cdc.gov)
  • Brucella melitensis, biotype 2, a continué à augmenter à tel point que became more frequent than biotype 1. (who.int)
  • B. melitensis, bio type 3, ce biotype est désormais dominant par rapport au biotype 1. (who.int)
  • B. which had appeared in 1977, continued to occur, but its incidence melitensis, biotype 3, apparue en 1977, est restée présente, mais son was very limited. (who.int)
  • En ce qui concerne B. abortus, le biotype 1 est resté dominant, frequently. (who.int)
  • Centre de Référence a permis de constater l'existence de trois épi one was due to B. melitensis, biotype 1, in goat cheese, implicating démies. (who.int)
  • Au même moment was due to B. melitensis, biotype 2, and originated from a herd of une autre épidémie survenait dans une autre localité, atteignant ewes. (who.int)
  • elle était due à B. melitensis, biotype 2, et ment, affecting a dozen people and also related to a herd of ewes. (who.int)
Pathogenic1
ORGANISM2
  • Inadvertent exposures to brucellae in the clinical laboratory indicate a widespread lack of preparedness to cope with eventual biologic threats involving use of the organism. (cdc.gov)
  • Several biologic characteristics make brucellae easily transmissible within the close confinement of the clinical microbiology laboratory, including the facts that the infecting dose for humans is low, and the organism may enter the body in many ways relevant to laboratory practices (e.g., through the respiratory mucosa, conjunctivae, gastrointestinal tract, or abraded skin) ( 1 , 2 ). (cdc.gov)
Strain3
  • Mycoplasma fermentans (incognitus strain) probably comes from the nucleus of the Brucella bacterium. (bibliotecapleyades.net)
  • In most countries where B melitensis is endemic, vaccination with the Rev. 1 strain is common. (msdvetmanual.com)
  • Rev. 1 is an attenuated strain of B melitensis and is administered by SC or intraconjunctival routes. (msdvetmanual.com)
Cattle1
  • It is well established that cattle can be infected with B. melitensis and that sheep/goats may harbor B. abortus . (dovepress.com)
Livestock1
  • African Lineage Brucella melitensis Isolates from Omani Livestock. (cdc.gov)
Cerebrospinal fluid1
  • Three blood samples and one sample of cerebrospinal fluid were positive for Brucella melitensis . (researchsquare.com)
Bacterial2
  • Seeded media harbor considerable amounts of viable Brucella organisms, and routine bacteriologic procedures such as preparing, centrifuging, and vigorous agitation (vortexing) of bacterial suspensions, performing subcultures and biochemical testing, and particularly the catalase test, may create dangerous aerosols and the potential for accidental spillage ( 14 ). (cdc.gov)
  • Brucella melitensis DNA was detected in the mother's placental specimen by next-generation sequencing and bacterial identification under microscope proved chorioamnionitis. (researchsquare.com)
Antigen2
  • Brucella antigen in liver and spleen from Asian badgers infected with Brucella melitensis , northwestern China. (cdc.gov)
  • Previously, three B. melitensis peptides, rBtuB-Hia-FlgK showed antigen-specific immune responses in rodent models. (bvsalud.org)
Pathogen1
  • Re-emerging zoonotic pathogen Brucella spp. (bvsalud.org)
23081
  • We used Brucella reference strains ( B. melitensis 16M and B. abortus 2308) as positive controls and double-distilled water as a negative control. (cdc.gov)
Presumptively1
  • All isolates that are positive by the CLRN real-time PCR assay are considered as presumptively positive for Brucella spp. (publichealthontario.ca)
Putative1
  • We tested putative Brucella colonies by using H 2 S production, dye inhibition, agglutination by monospecific serum, and sensitivity to bacteriophages ( Appendix Table). (cdc.gov)
Bosnia and Herzego1
  • Structure of the scenario tree for the probability of Brucella melitensis ( Bm ) case detection based on testing of aborting small ruminants in Switzerland (CH) and Bosnia and Herzegovina (BH). (biomedcentral.com)
Specimen1
  • Hemoculture of his specimen revealed positive for Brucella melitensis a month after his death. (osirjournal.net)
Bacteremia1
  • This bacteremia has a continuous pattern, making circulating brucellae easily detectable by blood culture. (cdc.gov)
Sensitivity1
  • IMSEAR at SEARO: Drug sensitivity of Brucella melitensis. (who.int)
Prevalence1
  • This investigation was carried out to study the prevalence of Brucella spp. (who.int)
Spleen1
  • To detect Brucella antigens, we used immunohistochemical staining of liver and spleen tissue sections by pipetting mouse anti- Brucella melitensis IgG diluted 1:100 in 30% bovine serum albumin/phosphate-buffered saline onto each section. (cdc.gov)
Chamois1
  • Brucella melitensis has been isolated from wildlife, such as chamois ( Rupicapra rupicapra ) ( 2 ), Alpine ibex ( Capra ibex ) ( 3 ), and Iberian wild goat ( Capra pyrenaica ) ( 4 ). (cdc.gov)
Exposure1
  • Discovery of a laboratory exposure to brucellae should prompt an exhaustive investigation of the event and its circumstances, definition of the population at risk, enforcement of safe laboratory practices, and antimicrobial drug prophylaxis for exposed persons. (cdc.gov)
Assay1
  • Any isolate that is positive by the CLRN assay is considered as presumptive positive for Brucella spp. (publichealthontario.ca)
Wildlife1
  • Reemergence of We conducted our investigation animals) showed positive results in Brucella melitensis during the fall-winter of 2012-2013 the RBT, CFT, and both ELISAs, and in the entire massif where the outbreak 2 showed positive results only for in Wildlife, France occurred. (cdc.gov)
Immune response2
  • Prepatellar bursitis due to Brucella abortus: case report and analysis of the local immune response. (medscape.com)
  • The goal of this study was to evaluate the goat Th1/Th2 immune response to B. melitensis peptides. (bvsalud.org)
Gene1
  • The parallel gene expression profiles of Brucella melitensis and the host have not been elaborated. (tamu.edu)
Primarily1
  • While they researched a number of disease pathogens, they primarily focused on the Brucella bacterium and began to weaponise it. (bibliotecapleyades.net)
Detection1
  • 17 Classically, detection and identification of Brucella spp. (dovepress.com)
Rarely1
  • Avenida Brasil 4365, Manguinhos, 21040-900, ( 3 ), B. melitensis has rarely been iso- (online Appendix Table 1). (cdc.gov)
Identification1
  • 31 The IS711 element became the preferred target for general identification purposes due to its restricted occurrence in Brucella spp. (dovepress.com)
Positive1
Estimate1
  • The aim of our study was to estimate a representative seroprevalence of Brucella spp. (who.int)
Disease1
  • Researchers extracted this mycoplasma from the Brucella bacterium and actually reduced the disease to a crystalline form. (bibliotecapleyades.net)
Summary of Notifiable Diseases --- United States, 2003
Summary of Notifiable Diseases --- United States, 2003 (cdc.gov)
Summary of Notifiable Diseases --- United States, 2004
Summary of Notifiable Diseases --- United States, 2004 (cdc.gov)
Summary of Notifiable Diseases --- United States, 2002
Summary of Notifiable Diseases --- United States, 2002 (cdc.gov)
العربية
العربية (extranet.who.int)
Observations on brucellosis due to Brucella melitensis*
Observations on brucellosis due to Brucella melitensis* (extranet.who.int)
Summary of Notifiable Diseases --- United States, 2005
Summary of Notifiable Diseases --- United States, 2005 (cdc.gov)
Summary of Notifiable Diseases --- United States, 2006
Summary of Notifiable Diseases --- United States, 2006 (cdc.gov)
Detecting Biological Warfare Agents - Volume 11, Number 10-October 2005 - Emerging Infectious Diseases journal - CDC
Detecting Biological Warfare Agents - Volume 11, Number 10-October 2005 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Brucellosis: MedlinePlus Medical Encyclopedia
Brucellosis: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Volume 26, Number 4-April 2020 - Emerging Infectious Diseases journal - CDC
Volume 26, Number 4-April 2020 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Pages that link to Brucella melitensis - microbewiki
Pages that link to "Brucella melitensis" - microbewiki (microbewiki.kenyon.edu)
Volume 20, Number 9-September 2014 - Emerging Infectious Diseases journal - CDC
Volume 20, Number 9-September 2014 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Bacterial Zoonoses and Infective Endocarditis, Algeria - Volume 11, Number 2-February 2005 - Emerging Infectious Diseases...
Bacterial Zoonoses and Infective Endocarditis, Algeria - Volume 11, Number 2-February 2005 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Letters - Emerging Infectious Diseases journal - CDC
Letters - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Misidentification with MALDI-TOF MS - Canada.ca
Misidentification with MALDI-TOF MS - Canada.ca (canada.ca)
Prepatellar Bursitis Workup: Laboratory Studies, Imaging Studies, Procedures
Prepatellar Bursitis Workup: Laboratory Studies, Imaging Studies, Procedures (emedicine.medscape.com)
(emedicine.medscape.com)
Volume 21, Number 1-January 2015 - Emerging Infectious Diseases journal - CDC
Volume 21, Number 1-January 2015 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Bursitis: Practice Essentials, Anatomy, Pathophysiology
Bursitis: Practice Essentials, Anatomy, Pathophysiology (medscape.com)
Figure - Exotic Small Mammals as Potential Reservoirs of Zoonotic Bartonella spp. - Volume 15, Number 4-April 2009 - Emerging...
Figure - Exotic Small Mammals as Potential Reservoirs of Zoonotic Bartonella spp. - Volume 15, Number 4-April 2009 - Emerging... (wwwnc.cdc.gov)
An epidemiological profile of brucellosis in Tabuk Province, Saudi Arabia
An epidemiological profile of brucellosis in Tabuk Province, Saudi Arabia (apps.who.int)
WHO EMRO | Prevalence of bovine and human brucellosis in western Algeria: comparison of screening tests | Volume 12, issue 1/2 ...
WHO EMRO | Prevalence of bovine and human brucellosis in western Algeria: comparison of screening tests | Volume 12, issue 1/2 ... (emro.who.int)
Typhoid Fever Follow-up: Further Outpatient Care, Further Inpatient Care, Deterrence/Prevention
Typhoid Fever Follow-up: Further Outpatient Care, Further Inpatient Care, Deterrence/Prevention (medscape.com)
Multiple Cranial Nerve Involvement Caused by Brucella melitensis
Multiple Cranial Nerve Involvement Caused by Brucella melitensis (medscape.com)
DailyMed - BRUC HOMO- brucella melitensis liquid
DailyMed - BRUC HOMO- brucella melitensis liquid (dailymed.nlm.nih.gov)
Brucellosis: Background, Pathophysiology, Etiology
Brucellosis: Background, Pathophysiology, Etiology (medscape.com)