A plant genus of the family SIMAROUBACEAE. Members contain bruceosides and bruceanols (quassinoids). The astringent seeds have been used to treat dysentery in southeastern Asia.
A group of degraded TRITERPENES which have lost ten carbons (8 from the side chain, C17, and one from C4) so have C20 skeletons which could be misinterpreted as DITERPENES. They especially occur in plants of the SIMAROUBACEAE family.
(1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.
Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
Heterodimers of FLAVONOIDS bound to LIGNANS.
A plant genus of the family POACEAE. The seed is used in folk medicine (DRUGS, CHINESE HERBAL).

Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc. (1/11)

Employing the natural product quassinoid brusatol, we currently report cellular and molecular events leading to cell death or terminal differentiation in a panel of leukemic cells. Brusatol and bruceantin exerted significant cytotoxic effects with several leukemic cell lines, but not with K562 or normal lymphocytic cells. Cell lines that were less sensitive to the cytotoxic effects of brusatol responded primarily through induction of terminal differentiation. The differentiated phenotype in cell lines derived from acute or chronic myeloid leukemias (HL-60, K562, Kasumi-1, NB4, U937, BV173) was characterized for producing superoxide and non-specific esterase, and some with up-regulation of CD13 (cluster of differentiation) and down-regulation of CD15. Chronic myeloid leukemic cell lines, K562 and BV173, and acute lymphoblastic cell lines, SUPB13 and RS4;11, were induced to differentiate along the erythrocytic pathway. Withdrawal studies showed that brusatol treatment for 48 h was sufficient to induce commitment towards terminal differentiation in HL-60, K562 and SUPB13. Reh cells did not undergo maturation. Analysis of c-MYC protein expression revealed that brusatol or bruceantin down-regulated expression to undetectable levels in cell lines that were most sensitive, based on cell death or terminal differentiation. Generally, c-myc RNA was reduced, but to a lower extent than c-MYC protein levels, indicating c-myc expression was regulated by quassinoids at the post-transcriptional level. Thus, regulation of c-myc expression may represent a critical event that leads to terminal differentiation. Since these responses are facilitated at clinically achievable concentrations, quassinoids may be of value for the management of hematological malignancies.  (+info)

Formulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application. (2/11)

The purpose of this study was to prepare and evaluate the intravenous emulsion (BCOE) containing Brucea javanica oil (BJO) and Coix seed oil (CSO), which is used in anti-tumor treatment. The formulation and preparation of BCOE were systematically investigated. High-pressure homogenization, particle size distribution, zeta-potential and HPLC were carried out. The pharmacokinetics of the main component, oleic acid, and anti-tumor activity studies about the tumor growth inhibitory ratios (TGIR) and the mortality experiments were also employed to evaluate BCOE in vivo compared with BJO emulsion (BJOE) and CSO emulsion (CSOE) using S180 sarcoma-bearing mice. The final BCOE formulation was 10% (w/v) oils with BJO and CSO 3 : 1, 0.6% (w/v) Lipid E 80, 0.3% (w/v) Pluronic F-68 (F-68), 0.1% (w/v) sodium oleate and 2.5% (w/v) glycerin in water. The preparation conditions involved 70 degrees C for preparing the crude emulsion, 6 cycles for high-pressure homogenization at 500 bar, pH value was adjusted to 8.5 after high-pressure homogenization and 115 degrees C for 30 min in a rotating water bath for sterilization. The pharmacokinetics parameters showed the combination of BJO and CSO may not influence the elimination of BCOE and have no significant difference between BCOE and BJOE or CSOE. The data of TGIR and mortality indicated that BCOE could increase the anti-tumor activity of CSOE and reduced the toxicity of BJOE. The mortality study (BCOE 0, BJOE 63.3%, CSOE 13.3%) showed that BCOE greatly reduced the toxicity of BJOE and CSOE. Therefore, the development and application of BCOE will make an important contribution to anti-tumor therapy.  (+info)

Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. (3/11)

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Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. (4/11)

Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo. Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. An untreated dog developed typical acute babesiosis symptoms including severe anemia, high fever, and complete loss of appetite and movement. However, the two bruceine A-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks although complete elimination of parasites from the peripheral blood was not achieved and decreases in the packed cell volume and the erythrocyte and platelet counts were observed. Since natural quassinoid compounds have been used as traditional medicines for the treatment of various ailments including cancer and malaria, the present results suggest that bruceine A or other related compounds are potential candidates for the treatment of canine babesiosis.  (+info)

Isolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis. (5/11)

One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6, 7.6, 15.6, 10.0, and 0.6 microg/ml, respectively.  (+info)

Preparation, safety, pharmacokinetics, and pharmacodynamics of liposomes containing Brucea javanica oil. (6/11)

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NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species. (7/11)

AIM: Brucea javanica was studied to identify nuclear factor kappaB (NF-kappaB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND METHODS: Eight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-kappaB assay. Active compounds were then tested using ROS and mitochondria transmembrane potential (MTP) assays. NF-kappaB and nuclear factor activated T-cell (NFAT) translocation were also assessed using their respective whole cell assays. RESULTS: Bruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-kappaB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells with greater potency and also showed an ability to up-regulate NFAT transcriptional pathways through the amplification of intracellular ROS, in the presence of H2O2, to a greater degree than bruceantin and bruceine. CONCLUSION: Chrysoeriol selectively kills leukemic cells and potentiates the amplification of ROS levels. Therefore, chrysoeriol could serve as a potential chemotherapeutic modifier for leukemia chemotherapy since leukemia cells have a higher susceptibility to elevated ROS levels.  (+info)

Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica. (8/11)

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The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. The small droplet size enabled the microemulsion droplets to escape from uptake and phagocytosis from the reticuloendothelial system and improved the circulation time of the drug. The zeta potential was ?41.3 mV. The optimized microemulsion was pale yellow, transparent, and non-opalescent in appearance. The value of the combination index was 0.58, showing that there was a synergistic effect when docetaxel was combined with Brucea javanica oil. After a single intravenous infusion dose (10 mg/kg) in Rabbit Polyclonal to PEA-15 (phospho-Ser104) male Sprague Dawley rats, the area under the curve of the microemulsion was higher and the half-time was longer compared with that of docetaxel remedy alone, and showed superior pharmacokinetic characteristics. These results indicate that this preparation of ...
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Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy. Methodology/Principal Findings: In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from MDR, we designed and evaluated a novel drug delivery system for MDR1 siRNA delivery. Novel biocompatible, lipid-modified dextran-based polymeric nanoparticles were used as the platform for MDR1 siRNA delivery; and the efficacy of combination therapy with this system was evaluated. In this study, multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluoresence were analyzed. Combination therapy of
We evaluated the safety and efficacy of induction chemotherapy with bevacizumab followed by maintenance chemotherapy with bevacizumab for advanced non-small cell lung cancer (NSCLC) in this multicenter phase II study. Chemotherapy-naïve patient with stage IIIB-IV or recurrent nonsquamous NSCLC were eligible. We planned approximately four cycles of induction cisplatin (75 mg/m2), pemetrexed (500 mg/m2), and bevacizumab (15 mg/kg) followed by maintenance with pemetrexed (500 mg/m2) and bevacizumab (15 mg/kg) until disease progression. Progression-free survival (PFS) was the primary endpoint. Forty patients received a median of four induction chemotherapy cycles. Of them, 35 (87.5%) patients received a median of nine maintenance chemotherapy cycles. The objective response was 70.6%, and the disease control rate was 97.1%. The median PFS was 10.8 (95% CI, 9.0-12.6), and overall survival was 48.0 (95% CI, 32.9-63.1) months. Median PFS of 23 patients with epidermal growth factor receptor (EGFR) mutations and
This trial will investigate the efficacy and tolerability of capecitabine [Xeloda] + oxaliplatin in patients with relapsed or refractory gastric cancer. The
This study investigated if the new orally active iron chelator, ICL670, is as safe as deferoxamine in preventing accumulation of iron in the body while a
Image: preventdisease.com. Beyond limited empirical observations, not all medicinal plants have established scientific studies to support their effectiveness. However, in the case of Brucea javanica, it is one of those plants in which scientific investigations have provided enough evidence to prove that it has an impressive efficacy for the treatment of cervical, bladder and pancreatic cancers. Its selective toxicity has also been found to kill 70% of breast cancer cells.. Oncologists are still at a loss to find methods of selectively killing cancer cells through the standard protocols of treatment in chemotherapy and radiation. While damaging healthy cells is an inevitable process through most cytotoxic drugs, chemotherapy also triggers them to secrete a protein that sustains tumour growth and resistance to further treatment.. The Rest Of The Story… ...
Glazba u Obitelji Soprano, HBO-ovoj televizijskoj seriji, ima vrlo važnu ulogu. Serija je zaradila pozitivne kritike baš zbog efektnog izbora eklektičnog glazbenog repertoara prethodno snimljene glazbe.[1][2][3][4] Autor serije David Chase osobno je izabirao glazbu za seriju s producentom Martinom Bruestleom i glazbenom urednicom Kathryn Dayak, ponekad se konzultirajući sa Stevenom Van Zandtom, koji je, osim što u seriji portretira Silvija Dantea, i gitarist E Street Banda Brucea Springsteena.[1] Glazba je obično birana kad bi produkcija i montaža epizode bili dovršeni, ali su ponekad sekvence snimane kako bi odgovarale prethodno odabranoj glazbi.[5] Stilski, glazba u seriji varira od mainstream popa (Britney Spears, The Bangles) preko britanskog rocka šezdesetih (The Kinks, The Rolling Stones) do klasičnog jazza i soula (Ella Fitzgerald, Ben E. King) te hip-hopa (Xzibit, Time Zone).[6] ...
Dear Histonetters, I am looking for stains that will identify the basic contents of cultured, mammary alveoli (mammospheres) of Kangaroo. Broad lipid ( ANY FAT STAIN THAT CAN BE DONE ON PARAFFIN EMBEDDED TISSUE???POSSIBLE??), carbohydrate (PAS?? ANY OTHER SUGGESTIONS) and protein stains (???) are required to determine what - IF any, different hormone combinations have/ effect on milk production. Any suggestions would be wonderful......our Histologist has made several good suggestions for me to try & we are both interested to see WHAT POSSIBILITIES/suggestions the scientific minds in Histo-land come up with. Thankyou in advance & Cheers, Sonia -- BRUCE ABALOZ PH:61383446282 HISTOLOGIST FAX:61383447909 DEPT.of ZOOLOGY EMAIL: brucea[email protected] THE UNIVERSITY Of MELBOURNE. VICTORIA. AUSTRALIA 3010 Nobody Can Make You Feel Inferior Without YOUR Permission - Eleanor Roosevelt DANCE LIKE NO-ONES WATCHING Q: Whats a specimen? A: An Italian astronaut. ...
There has been a recent eruption (sorry bout that) of research geared toward discovering the first vaccine to treat and/or prevent genital herpes. You can add one more contender - Michigan-based NanoBio Corporation. The company just got a NIH grant to do Phase II trials on a promising herpes vaccine.
Auxilium Pharmaceuticals recently dosed its first patient for the phase II study on Xiaflex for the treatment of frozen shoulder syndrome (adhesive capsulitis).
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
PhyCox One Soft Chews is a patented joint support formula with a combination of natural compounds and synergistic ingredients to reduce inflammation and provide a joint support matrix for healthy synovial maintenance as well as bone and muscle support.
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FOCUS formula is a special blend of Amino Acids, herbs and synergistic ingredients designed to support mental alertness, focus and memory. Stimulant free this powerful FOCUS formula can be used before any activity which requires increased focus, drive and determination. The amino acids that have been used in this formula have shown in studies to reduce environmental stress, and to increase the availability of neurotransmitters to the brain. The adaptogenic herbs are used traditionally to help reduce the physical and mental effects of stress on the body.. The support from nitrates rounds the formula off nicely providing an effective clinical dose that stimulates blood flow and increases oxygen delivery. The absence of stimulants means FOCUS formula can assist with preventing burnout and fatigue-based conditions, most often caused by the overuse of stimulant based pre-workout supplement regimes. Gram for gram FOCUS formula is one of the strongest and most comprehensive formulas of its kind.. ...
Collagen is an important complex protein in the body that provides structural integrity to key areas such as the skin, hair, nails, bones, joints, tendons, ligaments, cartilage, fascia, teeth, gums and blood vessels. In fact, collagen is responsible for making up 75% of our skin composition. Coll-Force is more than just collagen! It contains a tailored combination of marine collagen, as well as a clever vitamin, mineral, herbal and nutrient blend that is designed to work from within to help protect the body on a cellular level against ageing and oxidative stress. These synergistic ingredients also help to keep skin elastic, radiant and supple, and their actions are backed by science, with a number of EFSA (European Food Safety Authority) approved health claims. Suitable for people on a pescatarian diet
Pet-Enzymes Plus ™ Joint relief and allergy support. Better than Glucosamine and Chondroitin Sulfate. With 14 synergistic ingredients together for a systemic enzyme high-potent joint and allergy support formula for your dog or cats.
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Next Level Focus is a custom blend of L-theanine + Caffeine + Magnesium. A perfect blend of synergistic ingredients to deliver a powerful, relaxed energy boost.
Pituitary Complex Glandular is designed for use under the supervision of a healthcare practitioner. Please call (800) 669-0358 to speak with one of our practitioners or email us at [email protected] to request a password. Product DescriptionPituitary glandular with synergistic ingredients. ____________________
Intravenous lipid constituents have different effects on various biological processes. Some of these effects are protective, while others are potentially adverse. Phytosterols, in particular, seem to
A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer
LAssociazione ha lo scopo di promuovere il progresso oncologico nel campo clinico, sperimentale e socio-assistenziale, la prevenzione primaria e secondaria, la qualità delle cure oncologiche, la continuità terapeutica del paziente oncologico, Home - AIOM - Associazione Italiana di Oncologia Medica
As the cost of drug development is always many times more than that of drug discovery, predictive methods aiding in the screening of bioavailable drug candidates are of profound significance. In this paper, a novel method for screening bioactive compounds from traditional Chinese medicines (TCMs) was developed by using living cell extract and gas chromatography (GC)-mass spectrometer (MS). The method was validated by using elemene emulsion injection (EEI), a typical TCM with known active compound, to interact with murine ascites hepatocarcinoma cell strain with high metastatic potential (HCa-F). Finally, the method was applied to screen the bioactive compounds from multi-component zedoary turmeric oil and glucose injection (ZTOGI). After HCa-F cells was incubated in ZTOGI, ethyl acetate (EtOAc) was used to extract the compounds in the cells for GC-MS analysis. Fourteen compounds were detected in the desorption eluate of HCa-F cell extract of ZTOGI, and further identified by MS. Curzerene and ...
Dear Histonetters, Am wondering whether any of you, know of/recommend a good staining technique for the detection of lipopolysaccharide (LPS). Silver staining is often done to detect H. pylori in situ, I think because it does stain LPS, but I am wondering whether I could use it to visualize an enriched flagella prep (the flagella are about 1-2 um long). Appreciate any response, Cheers - Bruce in OZ -- BRUCE ABALOZ PH:61383446282 HISTOLOGIST FAX:61383447909 DEPT.of ZOOLOGY EMAIL: [email protected] THE UNIVERSITY Of MELBOURNE. VICTORIA.AUSTRALIA 3010 http://www.zoology.unimelb.edu.au/ Nobody can make you feel inferior without your permission. - Eleanor Roosevelt DANCE LIKE NO-ONES WATCHING ******************************************************************************** This email and any attachments may contain personal information or information that is otherwise privileged, confidential or otherwise protected from disclosure/subject of copyright. Any use, disclosure or copying of any part ...
H(070) rabies, bark of Clausena anisata, leaves of Sida rhombifolia, root of Cucumis ficifolius, bark root of Brucea antidysentrica powdered together and mixed in milk then drunk a cup of tea for three days in order to get cured from rabies disease ...
A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes the carrier nature, particle size and size distribution, morphology, surfactant stabiliser according to the technique applied, drug-loading ratio and encapsulation efficiency, surface property, etc. All will influence the in vitro release, in vivo behaviour and tissue distribution of administered particulate drug loaded nanoparticles. The main purpose of the present work was to determine the effect of drug loading ratio when employing TPGS as surfactant stabiliser and/or matrix material to improve the nanoparticulate formulation. The model drug employed was paclitaxel ...
TY - JOUR. T1 - Effect of β-Blocker in Treatment-Naïve Patients With Advanced Lung Adenocarcinoma Receiving First-Generation EGFR-TKIs. AU - Chang, Chia Hao. AU - Lee, Chih Hsin. AU - Ko, Jen Chung. AU - Chang, Lih Yu. AU - Lee, Ming Chia. AU - Zhang, Jun Fu. AU - Wang, Jann Yuan. AU - Shih, Jin Yuan. AU - Yu, Chong Jen. N1 - Funding Information: This study was supported by the Centers for Disease Control, Taiwan (MOHW104-CDC-C-114-122202; MOHW105-CDC-C-114-000103). The funding sources had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This is not a National Institutes of Health-sponsored study. Publisher Copyright: © Copyright © 2020 Chang, Lee, Ko, Chang, Lee, Zhang, Wang, Shih and Yu. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/10/28. Y1 - 2020/10/28. N2 - Background: Through activation of adrenergic receptors, chronic stress can trigger the secretion of neurotransmitters and hormones that ...
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
NO CRASH THERMOGENIC. A science-backed, cutting-edge formula that contains patented ingredients for rapid and sustained release thermogenesis, RESULTS SCULPTIFY™ begins working immediately, increasing thermogenesis, lipolysis (fat burning) and overall mental focus and clarity. Unlike traditional fat burners that can spike energy and crash energy quickly, leaving you with little else, RESULTS SCULPTIFY™ is formulated with specific ingredients that will deliver rapid and sustained energy levels. A primary stimulant in the RESULTS SCULPTIFY™ formula was clinically proven to last 6 times longer than traditional caffeine alone! Each serving also contains the patented Advantra Z®, which is structurally similar to ephedrine but works by activating different beta receptors to trigger fat release and metabolism. This thermogenic compound promotes fat oxidation, without the jittery effects associated with ephedrine. RESULTS SCULPTIFY™ delivers a blend of synergistic ingredients that stimulate ...
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Experiments on the orientation of Meloidogyne javanica larvae relative to roots are described which support the root-attraction hypothesis in contrast to the random-movement hypothesis. Further experiments on the nature of this attraction to roots suggest that it is probably due to several stimuli which may vary in importance.
Primalan Finest Almond Oil Emulsion can be used best in conjunction with Dolerma. Recommended use is to apply Dolerma first and follow up with Primalan. Primala
B. javanica seeds exhibit intermediate storage behaviour characterized as being tolerant to desiccation but sensitive to freezing temperatures. Freshly mature seeds survive when they are desiccated to 5.3-12.5% MCs. Viability of seeds with 3.7-12.5% MCs drop significantly at -20oC after 24 months of hermetic storage. The optimum seed moisture contents of B. javanica are 8, 5-13, and 5-8% for -20, 4, and 15oC storage, respectively. Longevity of seeds stored at 4oC is better than those at -20 and 15oC (Yang-JengChuann et al., 2006 ...
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ST-Phile was a media science fiction fanzine devoted to Star Trek published by Juanita Coulson, and edited by Juanita Coulson and Kay Anderson. ST-Phile was published in Indiana, U.S.A., and was first released in January 1968, during the broadcast of the original Star Trek television series. It was a mimeographed publication of 29 pages, and was entirely non-fiction, featuring articles, essays, verse and art work. Art work for the first issue was by John D. Berry (Egoboo), Juanita Coulson, Margaret Dominick, Devra Langsam (Spockanalia), Charles Rein, and Bjo Trimble (Melange, Shangri LAffaires), with a front cover by Doug Lovenstein. Contributors of writing included articles by Kay Anderson, Ruth Berman (Despatch, Inside Star Trek, T-Negative), Juanita Coulson, S.M. Hereford, Shirley Meech (Plak-Tow), Gene Roddenberry, Bjo Trimble, John Trimble (Pas-Tell, Melange, Shangri LAffaires), and Bob Vardeman (Sandworm). The second issue was released in November 1968, and is 44 pages. The art work for ...
1BJO: Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate.
IMPORTANT MESSAGE: COVID-19 ALERT Due to the Coronavirus pandemic outbreak, there has been an exponential increase in demand for medical supplies as a result of COVID-19, creating the possibility of processing delays. Accordingly, please be patient with expected delays to our normal one to three business day shipping practice. Please be assured,we are taking every precaution here to make sure your packages are delivered on time and without incident. We are eternally grateful for your continued faith and trust in our unwavering dedication to accommodate all of our customers in these challenging times. ...
Teng-Long-Bu-Zhong-Tang (TLBZT) is a Chinese language organic formula for colorectal carcinoma treatment. treatment. (Teng-Li-Geng, 30 g), (Long-Kui, 15 g), (She-Mei, 15 g), (Bai-Zhu, 9 g), Coix seed ... Read More ...
|head| |meta http-equiv=Content-Type content=text/html; charset=utf-8| |/head| Kabelo ke padinyana ye e ngwaletšwego bafsa. E ngwadilwe ka bokgwari bjo bogolo. Sa go phagamiša maemo a yona le go feta ke gore moanegwathwadi wa yona, e
In the present study, we demonstrated PCV and EGFR mutation status as independent prognostic factors in untreated advanced lung adenocarcinoma patients. We also showed that PCV , 2.2 ng/ml was a predictor of a favorable outcome in both advanced lung adenocarcinoma patients with wild-type and mutant EGFR.. Serum CYFRA 21-1 has been reported as a prognostic factor in patients with a variety of cancer types, including resectable NSCLC [39, 40], biliary tract cancer [41], urothelial cancer [42], head and neck cancer [43], esophageal cancer [44], and cervical cancer [45].. A meta-analysis of CYFRA 21-1 as a prognostic indicator in advanced NSCLC patients showed that the PCV may be a reliable prognostic factor [29], however, since non-adenocarcinoma accounted for 65% of the cases and squamous cell carcinoma for 50%, the role of serum CYFRA 21-1 as a prognostic indicator in the lung adenocarcinoma population remained unclear. Moreover, in a study of PCV as a prognostic indicator in advanced NSCLC ...
RESULTS AND DISCUSSION. All of the treatments had significantly lower aboveground weights compared to the control treatment without fungus and nematode. It was found that the weight of aboveground parts of to mato plants cultivated in pots without nematodes was lower than those infested with M. javanica (Table 1). The application of fungal isolates Pc-3, Pc-10, and Pc-28 of P. chlamydosporia var. chlam-ydosporia to the soil, individually or combined did not reduce the number of galls of M. javanica when compared to the nematode alone treatment (Table 1). There was a significant difference in the number of M. javanica eggs per root when the fungal isolate Pc-10 was incorporated individual ly into the soil compared to the nematode alone (307.7 and 597.2 eggs per root, respectively).. Previous experiments (Lopes et al., 2007; Dallemole-Giaretta et al., 2012) with the same fungal isolates used in this experiment demonstrated that they are able to control the root-knot nematode. However, the results ...
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Brief Introduction 60%-70% of the vitamins, minerals and essential amino acids in rice are accumulated in the outer layer. The white rice we usually eat is white and delicate, but the nutritional valu...
Purpose: ,p,Genomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with non-small cell lung adenocarcinoma (NSCLC) were ascertained and correlated with clinical characteristics and therapeutic outcomes.,/p, ,br /,,br /,Experimental Design: Comprehensive plasma ctDNA testing was performed in 88 consecutive patients; 34 also had tissue next generation sequencing; 29, other forms of genotyping; and 25 (28.4%) had no tissue molecular tests because of inadequate tissue or biopsy contraindications.,br /,,br /,Results: ,p,Seventy-two patients (82%) had ≥ 1 ctDNA alteration(s); amongst these, 75% carried alteration(s) potentially actionable by FDA-approved (61.1%) or experimental drug(s) in clinical trials (additional 13.9%). The most frequent alterations were in TP53 (44.3% of patients), EGFR (27.3%), MET (14.8%), KRAS (13.6%), and ALK (6.8%) genes. The concordance rate for EGFR alterations was 80.8% (100% versus 61.5% (≤ 1 versus , 1 month between tests; P = 0.04)) for ...
The first generation EGFR TKIs gefitinib and erlotinib provide significant clinical benefit in patients with advanced lung adenocarcinoma harbouring activating EGFR mutants (EGFRm+), but patients will ultimately develop disease progression due to acquired resistance. Acquisition of the EGFR T790M mutation is the most common mechanism of drug resistance, detected in more than 50% of gefitinib/erlotinib resistant patients. Current therapeutic strategies are limited for advanced lung adenocarcinoma patients with EGFR T790M (EGFRm+/T790M), so this remains a key area of unmet need. AZD9291 (structure to be disclosed at meeting) is an oral, irreversible, third generation, selective inhibitor of both EGFR activating (EGFRm+) and resistance (EGFRm+/T790M) mutations. The mechanistic and functional activity of AZD9291 was characterised in vitro and in vivo across a number of cell lines harbouring various EGFR-mutations or wild type EGFR. Presented data shows AZD9291 potently inhibits EGFR phosphorylation ...
Dorian Yates Vitamin C with Citrus Bioflavonoids is a combination of vitamin C, and synergistic ingredients formulated for optimal digestion and absorption.
In situ effective separation of oil pollutants including oil spills and oil emulsions from water is an emerging technology yet remains challenging. Hydrophobic micro- or nano-materials with ferromagnetism have been explored for oil removal, yet the separation efficiency of an oil emulsion was compromised due to the
This made me to think about invasive cover crops like - Pueraria Javanica (Tropical Kudzu) and Mucuna Bracteta. Mucuna was seen in rubber plantations in Kerala and they keep a ground cover green even during peak summer. I searched to check if anyone is using in orchards and found two farmers in Kerala. One was a farmer from Kannur, Kerala named Francis and he used Mucuna as cover crop in his pepper crop - www.nif.org.in/upload/pdf_file/francis_pa.pdf. Talked to him and he was recommending Mucuna and even though it is invasive, it can be easily controlled. Another farmer was Jayadevan, Alanellur, Kerala and he was not completely for it, since it just takes over and spreads to different places and it can not be used as fodder. He had used it in one area of coconut farm and that area didnt require any watering, he was planning to replace it. Since there were plenty of red ants, there was no threat of snakes. I talked to Kailashamurthy of Mysore and he suggested to use Pueraria. Pueraria also is ...
Shorea javanica is an evergreen Tree growing to 40 m (131ft) by 30 m (98ft) at a fast rate. It is hardy to zone (UK) 10. The species is hermaphrodite (has both male and female organs) and is pollinated by Thrips, Insects. The plant is not self-fertile. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils, prefers well-drained soil and can grow in heavy clay soil. Suitable pH: acid, neutral and basic (alkaline) soils and can grow in very acid and very alkaline soils. It cannot grow in the shade. It prefers moist soil.
Varieties javanica: with the name O. sativa var. javanica are broad-grained and thrives under tropical conditions, was identified based on morphology and initially called javanica, but is now known as tropical japonica with the name O. sativa var. tropical japonica. Examples of these varieties include the medium grain Tinawon and Unoy cultivars, which are grown in the high-elevation rice terraces of the ...
Meskipun cuma satu foto tapi ini satu bukti yang harus tetap dipertahankan. Jenis ini ternyata jenis endemik Jawa. Capung dengan ukuran besar ini menarik sekali untuk diabadikan. Hari ini (26/04/13) bersama sesepuh Indonesia Dragonfly Society capung besar ini terlihat sedang berjemur dekat rumpun bambu yang tidak jauh dari sumber air, Sungai. Memang beda kalau kalau…
International Knowledge Press (IKP) is a publisher of peer reviewed, international journals and books. We are committed to provide Fast and Quality service for the scholarly community.
An objective postprocessing technique for detecting SLS in radiographic images of BSCC heart valves has been developed. The results of this study indicate that two of the quantitative variables developed for detecting SLS (namely, DIPI ratio and gap half-width) are diagnostic and that the accuracy in detection of SLS with either of these two variables was equal to that of the expert subjective reviewers. Although offset appears to be a strong visual cue for the expert reviewers, the confounding factor of image magnification in this study made it difficult to adequately assess its utility as a discriminating variable. However, on the basis of the results before magnification, maximum offset deviation may also be significant in discriminating SLS legs. Due to the small sample size before magnification, it was not possible to develop a classification model based on both offset and gap measures. Yet this type of model could be the most accurate predictor of SLS and surpass the predictive ...
Conservative commentator and talk radio host Rush Limbaugh announced on Monday that he has been diagnosed with advanced lung cancer.
... erythraeae Chiov. Brucea guineensis G.Don Brucea javanica (L.) Merr. Brucea macrocarpa Stannard Brucea mollis Wall. ex ... Brucea tonkinensis (Lecomte) Gagnep. Brucea trichotoma Spreng. "Genus: Brucea J.F.Mill". Germplasm Resources Information ... It contains the following species (this list may be incomplete): Brucea antidysenterica J.F.Mill. Brucea bruceadelpha (Noot.) ... Brucea is a genus of plant in the family Simaroubaceae. It is named for the Scottish scholar and explorer James Bruce. ...
... is a species of plant in the Simaroubaceae family. It is endemic to Kenya, and is being threatened by habitat ... Luke, W.R.Q.; Musili, P.; Barasa, J.; Kalema, J.; Mathenge, J.; Nemomissa, S.; Bahdon, J. (2018). "Brucea macrocarpa". IUCN Red ... Brucea, Endemic flora of Kenya, Taxonomy articles created by Polbot, All stub articles, Sapindales stubs). ...
"Brucea javanica (L.) Merr". The Plant List. Retrieved 20 March 2015. "Brucea javanica". Germplasm Resources Information Network ... Brucea javanica grows up as a shrub or small tree to 5 metres (20 ft) tall. The tiny flowers (1.5--2 mm in diameter) are ... Brucea javanica (also known as Macassar kernels) is a shrub in the family Simaroubaceae. The specific epithet javanica is from ... The fruit Brucea javanica was first written about as medicine in the Chinese medical monograph Omissions from the Grand Materia ...
ISBN 978-1-899468-67-6. "Daniel Bruce - A Squad". Scottish Football Association. Archived from the original on 16 June 2011. " ...
... s are quassinoids isolated from Brucea antidysenterica. Bruceanol A Bruceanol B Bruceanol C Bruceanol D Bruceanol E ... Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
"Mt Bruce - a view from up above". Mt Bruce. Archived from the original on 16 July 2011. Retrieved 12 September 2012. (Articles ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol G is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol H is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
... , a new cytotoxic quassinoid from Brucea antidysenterica". Journal of Natural Products. 51 (2): 349-352. doi:10.1021 ... Bruceanol C is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
... is a chemical compound that was first isolated from the plant Brucea antidysenterica in 1973. Chemically, it is ... F D Gillin, D S Reiner, M Suffness (2021). "Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica". ... a new potent antileukemic simaroubolide from Brucea antidysenterica". J. Org. Chem. 38 (1): 178-179. doi:10.1021/jo00941a049.{{ ...
"ESTHER BRUCE - A BLACK LONDON SEAMSTRESS: HER STORY 1912-1994". www.stephenbourne.co.uk. Retrieved 2017-10-25. "Putting Black ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol A is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol E is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol B is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol F is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol D is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Brucea javanica oil, extracted from the seeds of the Brucea javanica. The oil has been shown to be effective in treating ... Zhang, Hong; Yang, Jing Yu; Zhou, Fan; Wang, Li Hui; Zhang, Wen; Sha, Sha; Wu, Chun Fu (2011). "Seed Oil of Brucea javanica ... Lou, Guo-Guang; Yao, Hang-Ping; Xie, Li-Ping (2010). "Brucea javanica Oil Induces Apoptosis in T24 Bladder Cancer Cells via ...
The Bartender (Robert Bruce) - A civilian and owner of a local bar. Tony Sparks Clark Walkington Frank Taurua Steve Nicolle ...
Brucea is the original name of Bruceomyces, published by Finnish mycologist Jouko Rikkinen in 2003. Rikkinen and colleagues ... renamed the genus in 2012 after it was discovered that Brucea was a junior homonym of a plant genus. The generic name honors ...
... and Brucea abortus. Clitocine has also been shown to promote apoptosis (cell death) in human cervical cancer cells in vitro ( ...
... is named from the genus Brucea, named after James Bruce who brought back Brucea antidysenterica from Ethiopia. Brucine ...
"Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of ...
Jamieson StuartW, Reitz BruceA, Oyer PhilipE, Billingham Margaret, Modry Dennis, Baldwin John, Stinson EdwardB, Hunt Sharon, ...
Walter Bruce-a known witch hunter-as minister of St Peter's. Bruce also played a pivotal role in initiating the so-called Great ...
pedicellata Species Bersama swynnertonii Bretschneidera sinensis Brucea macrocarpa Bulnesia carrapo Dipteronia dyeriana ...
This is partly explained by the loyalty of Sir Neil Campbell (Niall mac Caile), (d.1315), to the cause of Robert the Bruce - a ...
Dell Henderson - The Husband Stephanie Longfellow - The Wife Kate Bruce - A Neighbor William J. Butler - Pawnbroker Edward ...
A Tale of the Golden West Guy Boothby A Brighton Tragedy In Spite of the Czar The Stolen Peer Mary Grant Bruce - A Little Bush ...
... brucea MeSH B06.388.100.898.333 - eurycoma MeSH B06.388.100.898.555 - picrasma MeSH B06.388.100.898.599 - quassia MeSH B06.388. ...
Bruceomyces castoris was originally described by Rikkinen in 2003 as Brucea castoris, but was transferred to the newly ... circumscribed Bruceomyces in 2012 after it was discovered that Brucea was a junior homonym of a plant genus. The genus name ...
Nomad: Stopama Brucea Chatwina Poznati engleski putopisac i nepopravljivi nomad Bruce Chatwin (U Patagoniji) bio je ...
Bruce - A Tribute to a Friend and Genius. Photo - Jess Burbridge. Oteil Burbridge: "If youre lucky enough, youll meet someone ...
Oversized shirt cut from compact organic cotton poplin. Get ready to stand out in the crowd. Shop now on Diesel.com
Oversized shirt cut from compact organic cotton poplin. Get ready to stand out in the crowd. Shop now on Diesel.com
Posts about Ben Bruce written by anlapf
Posts about Lenny Bruce written by A History of Italy
I am very pleased to write and say that I have made donations to both the The Womens Centre Grey Bruce and to the David Suzuki Foundation, for those not Canadian David Suzuki is a long time environmental and climate change crusader. The donation, of over $100s comes from 10% of the sales I made during this year. Thank you for your purchases so that I can make these donations.. I chose these two organization for the following reasons:. Women have been very adversely affected by the Covid pandemic. They were trapped in abusive homes, and some were murdered. Many lost their jobs in the service and other sectors and the wage divide between men and women is reported to be widening. They are now talking about women not getting promoted as they may choose to work from home longer due to childcare responsibilities and will not make the contacts and be able to shine in person that encourages promotions. Very frustrating to see hard wins lost like this. Apart from this ongoing plague women are also ...
Curcuma xanthorrhiza, Brucea javanica, and Ficus septica may have potential to be developed as a combination with or without ... In Vitro Study of the Combination of Doxorubicin, Curcuma xanthorrhiza, Brucea javanica, and Ficus septica as a Potential Novel ... fruit of Brucea javanica (EBj), leave of Ficus septica (EFs) and doxorubicin (Dox) alone and its combination on migration and ...
Bruce-a-palooza Sun, Apr 30, 2023. 10 am - 4 pm. See Details ...
Pingback: 2019 Petrona Award Winner: The Katharina Code (Penguin, 2018) by Jørn Lier Horst; translated by Anne Bruce - A Crime ...
Biji buah wali (Brucea javanica (L.) Merr) merupakan bagian tanaman yang memiliki aktivitas antiinflamasi karena kandungannya ... OPTIMASI FORMULA SEDIAAN NANOEMULSI EKSTRAK BIJI WALI (Brucea javanica (L.) Merr) DENGAN METODE SIMPLEX LATTICE DESIGN ... BAIQ RIZKIA DWIYANA, MELIANDARI (2022) OPTIMASI FORMULA SEDIAAN NANOEMULSI EKSTRAK BIJI WALI (Brucea javanica (L.) Merr) DENGAN ...
Dr. Boston specializes in caring for infants, children and adolescents with endocrine or hormone problems. These include problems with growth, puberty, thyroid, adrenal and any other disorder related to the hormone glands. Dr. Boston also treats both type 1 and type 2 diabetes in children. As a specialist in pediatric diabetes, Dr. Boston takes a developmental and family centered approach to the care of diabetes in children and adolescents. This approach requires multiple diabetes team members specially trained in the care of kids with diabetes. These pediatric diabetes team members are all available at the Harold Schnitzer Diabetes Health Center. Dr. Boston is also very involved with the Gales Creek Camp for Children with Diabetes that offers a summer camping experience for children with type 1 diabetes and their families.. In his spare time, Dr. Boston enjoys spending time staying in shape with a weekly soccer game. He also enjoys traveling with his family and getting away to the gorgeous ...
Povratak Brucea Waynea. Grant Morrison. Chris Sprouse. Frazer Irving. Yanick Paquette. Ba en tisu e godina u pro lost, ovjek ...
Brucea antidysenterica. Waginos. Tree. 7.0. 10-12 M. LMH. FSN. M. 1. 4. 1. ...
Alkaline diet detox, detox foot patch for weight loss and improving health. Sold online at Sales offer here is only $45 per cannister with internationa shipping at...
Compare: Nux Vomica Nux; Ruta Graveolens Ruta; Merc Viv Mercur.; Brucea. - Bark of Nux Vomica Nux Vomica or angustura falsa ( ...
Since June 10 an undetermined number of Georgia prisoners have been on a hunger strike. Some of these men are the Jackson State prison strikers. After two weeks, according to the families of Miguel Jackson and Preston Whiting, they are weak from hunger and subject to fainting spells. But they seem to believe they have little to lose. They are, a letter from one of them asserts, "starving for change." We must demand justice for Miguel Jackson and other Georgia state prisoners who are being targeted and brutalized for exposing their inhumane conditions and standing up for their most basic human rights ...
America s Cate Blanchettovou aj predčasná smrť Brucea Leeho. Film a televízia VIDEO 22.05.2020 12:00 ...
U.S. Army Platoon Sergeant Bruce Alan Grandstaff was posthumously presented the Medal of Honor for military valor during the Vietnam War.
Local/Live from Anodyne on Bruce - A Holiday Special with Testa Rosa and special guest Mark Waldoch. ...
Three novel quassinoids, javanicolides A and B, and javanicoside A, from seeds of Brucea javanica. Kim, Ik Hwi,Suzuki, Ryoko, ... javanicoside A were isolated from the seeds of Brucea javanica Merr. (Simaroubaceae), along with four known quassinoids, ...
BruceA last edited by Hi Sam. They are updated on the 8th day after the campaigns where created and then on the subsequent 8th ...
In "Drowsiness with headache" Brucea, Herac., Gels., Nat. sul., Nux mos., and Sul. In dry lips, Bry. ...
We are privileged to work with some of the most exciting authors, chefs, illustrators and personalities in the world. Below you will find a sample of our clients which can be searched by first name, last name or title. For our full client list select, "Find by Name.". ...
Brucea javanica (L.) Merr. (Cambodia, Laos, Vietnam, Sri Lanka, Australia (N-Western Australia, coastal Northern Territory, ...
Michael Gough kao Alfred Pennyworth: Vjerni batler Brucea Waynea.. *Pat Hingle kao Načelnik James Gordon: Policijski načelnik ... Paulu Diniju se svidjela karakterizacija Brucea Waynea. Uobičajene kritike iz svijeta stripa odnosile su se na to kako Batman ...
brucea@dga.org Low Budget - LA, Barbara Berman (310) 289-2008. [email protected] ...
Project Noah is a tool that nature lovers can use to explore and document local wildlife and a common technology platform that research groups can use to harness the power of citizen scientists everywhere.
Šesti čut: odlična igra Bruce-a Willisa in malega. *Vsiljivci: na podoben način speljan konec ...
  • The aims of this study is to prove the inhibitory effect of ethanolic extract of rhizome of Curcuma xanthorrhiza (ECx), fruit of Brucea javanica (EBj), leave of Ficus septica (EFs) and doxorubicin (Dox) alone and its combination on migration and invasion of a highly metastatic 4T1 breast cancer cell line. (unej.ac.id)
  • Curcuma xanthorrhiza, Brucea javanica, and Ficus septica may have potential to be developed as a combination with or without doxorubicin for metastatic breast cancer treatment. (unej.ac.id)
  • Biji buah wali (Brucea javanica (L.) Merr) merupakan bagian tanaman yang memiliki aktivitas antiinflamasi karena kandungannya berupa senyawa fenolik dan triterpenoid. (unram.ac.id)
  • Brucea javanica (L.) Merr. (google.com)
  • Antidiabetic, antibacterial and antioxidant activities of different extracts from Brucea javanica (L.) Merr seeds. (ukrida.ac.id)
  • Brusatol (Bru), a Chinese medicine Brucea javanica extract, has a variety of antitumour effects. (bvsalud.org)
  • Prelomna kung fu klasika, ki je iz Brucea Leeja dokončno naredila legendo in kult tudi v Združenih državah Amerike. (siol.net)
  • Brucea mollis WALL. (frlht.org)
  • Chemical constituents from stems of Brucea mollis and their cytotoxic activity. (chemfaces.com)
  • Skupina teda prešla zvukovou a žánrovou premenou pod vplyvom producenta Electra records, Paul A. Rothchilda a zvukára Brucea Botnicka . (musicpress.sk)
  • Poleg originalnega albuma, bo razširjena verzija ponatisa vsebovala remasteriziran zvok dolgoletnega zvočnega inženirja in producenta skupine Brucea Botnicka ter dodatno zgoščenko, zapolnjeno z doslej neizdanimi, drugačnimi verzijami skladb, ki so se beležile na snemalne trakove v času snemanja albuma. (rockline.si)
  • Arthur odlazi do Wayne Manor, gdje susreće Thomasovog malog sina Brucea, ali bježi nakon svađe s obiteljskim bitkama Alfredom Pennyworthom. (instructure.com)
  • Album je obilježio povratak pjevača Brucea Dickinsona nakon šest i gitarista Adriana Smitha nakon devet godina. (wikipedia.org)
  • Njihova majka je domaćica Kris, a djevojke imaju i najmlađeg brata Roberta Jr.. Međutim, Robert i Kris su se 1990.g. rastali, da bi se Kris samo godinu dana kasnije udala za Brucea Jennera, olimpijskog pobjednika u desetoboju 1976.g. u Montrealu i strastvenog motivacijskog govornika s kojim ima još dvije kćeri, Kendall i Kylie Jenner. (tvprofil.com)