Brucea
Quassins
Glaucarubin
(1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.
Amebicides
Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc. (1/11)
Employing the natural product quassinoid brusatol, we currently report cellular and molecular events leading to cell death or terminal differentiation in a panel of leukemic cells. Brusatol and bruceantin exerted significant cytotoxic effects with several leukemic cell lines, but not with K562 or normal lymphocytic cells. Cell lines that were less sensitive to the cytotoxic effects of brusatol responded primarily through induction of terminal differentiation. The differentiated phenotype in cell lines derived from acute or chronic myeloid leukemias (HL-60, K562, Kasumi-1, NB4, U937, BV173) was characterized for producing superoxide and non-specific esterase, and some with up-regulation of CD13 (cluster of differentiation) and down-regulation of CD15. Chronic myeloid leukemic cell lines, K562 and BV173, and acute lymphoblastic cell lines, SUPB13 and RS4;11, were induced to differentiate along the erythrocytic pathway. Withdrawal studies showed that brusatol treatment for 48 h was sufficient to induce commitment towards terminal differentiation in HL-60, K562 and SUPB13. Reh cells did not undergo maturation. Analysis of c-MYC protein expression revealed that brusatol or bruceantin down-regulated expression to undetectable levels in cell lines that were most sensitive, based on cell death or terminal differentiation. Generally, c-myc RNA was reduced, but to a lower extent than c-MYC protein levels, indicating c-myc expression was regulated by quassinoids at the post-transcriptional level. Thus, regulation of c-myc expression may represent a critical event that leads to terminal differentiation. Since these responses are facilitated at clinically achievable concentrations, quassinoids may be of value for the management of hematological malignancies. (+info)Formulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application. (2/11)
The purpose of this study was to prepare and evaluate the intravenous emulsion (BCOE) containing Brucea javanica oil (BJO) and Coix seed oil (CSO), which is used in anti-tumor treatment. The formulation and preparation of BCOE were systematically investigated. High-pressure homogenization, particle size distribution, zeta-potential and HPLC were carried out. The pharmacokinetics of the main component, oleic acid, and anti-tumor activity studies about the tumor growth inhibitory ratios (TGIR) and the mortality experiments were also employed to evaluate BCOE in vivo compared with BJO emulsion (BJOE) and CSO emulsion (CSOE) using S180 sarcoma-bearing mice. The final BCOE formulation was 10% (w/v) oils with BJO and CSO 3 : 1, 0.6% (w/v) Lipid E 80, 0.3% (w/v) Pluronic F-68 (F-68), 0.1% (w/v) sodium oleate and 2.5% (w/v) glycerin in water. The preparation conditions involved 70 degrees C for preparing the crude emulsion, 6 cycles for high-pressure homogenization at 500 bar, pH value was adjusted to 8.5 after high-pressure homogenization and 115 degrees C for 30 min in a rotating water bath for sterilization. The pharmacokinetics parameters showed the combination of BJO and CSO may not influence the elimination of BCOE and have no significant difference between BCOE and BJOE or CSOE. The data of TGIR and mortality indicated that BCOE could increase the anti-tumor activity of CSOE and reduced the toxicity of BJOE. The mortality study (BCOE 0, BJOE 63.3%, CSOE 13.3%) showed that BCOE greatly reduced the toxicity of BJOE and CSOE. Therefore, the development and application of BCOE will make an important contribution to anti-tumor therapy. (+info)Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. (3/11)
(+info)Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. (4/11)
Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo. Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. An untreated dog developed typical acute babesiosis symptoms including severe anemia, high fever, and complete loss of appetite and movement. However, the two bruceine A-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks although complete elimination of parasites from the peripheral blood was not achieved and decreases in the packed cell volume and the erythrocyte and platelet counts were observed. Since natural quassinoid compounds have been used as traditional medicines for the treatment of various ailments including cancer and malaria, the present results suggest that bruceine A or other related compounds are potential candidates for the treatment of canine babesiosis. (+info)Isolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis. (5/11)
One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6, 7.6, 15.6, 10.0, and 0.6 microg/ml, respectively. (+info)Preparation, safety, pharmacokinetics, and pharmacodynamics of liposomes containing Brucea javanica oil. (6/11)
(+info)NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species. (7/11)
AIM: Brucea javanica was studied to identify nuclear factor kappaB (NF-kappaB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND METHODS: Eight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-kappaB assay. Active compounds were then tested using ROS and mitochondria transmembrane potential (MTP) assays. NF-kappaB and nuclear factor activated T-cell (NFAT) translocation were also assessed using their respective whole cell assays. RESULTS: Bruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-kappaB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells with greater potency and also showed an ability to up-regulate NFAT transcriptional pathways through the amplification of intracellular ROS, in the presence of H2O2, to a greater degree than bruceantin and bruceine. CONCLUSION: Chrysoeriol selectively kills leukemic cells and potentiates the amplification of ROS levels. Therefore, chrysoeriol could serve as a potential chemotherapeutic modifier for leukemia chemotherapy since leukemia cells have a higher susceptibility to elevated ROS levels. (+info)Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica. (8/11)
(+info)
1:08 pm
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Brucea
... erythraeae Chiov. Brucea guineensis G.Don Brucea javanica (L.) Merr. Brucea macrocarpa Stannard Brucea mollis Wall. ex ... Brucea tonkinensis (Lecomte) Gagnep. Brucea trichotoma Spreng. "Genus: Brucea J.F.Mill". Germplasm Resources Information ... It contains the following species (this list may be incomplete): Brucea antidysenterica J.F.Mill. Brucea bruceadelpha (Noot.) ... Brucea is a genus of plant in the family Simaroubaceae. It is named for the Scottish scholar and explorer James Bruce. ...
Brucea macrocarpa
... is a species of plant in the Simaroubaceae family. It is endemic to Kenya, and is being threatened by habitat ... Luke, W.R.Q.; Musili, P.; Barasa, J.; Kalema, J.; Mathenge, J.; Nemomissa, S.; Bahdon, J. (2018). "Brucea macrocarpa". IUCN Red ... Brucea, Endemic flora of Kenya, Taxonomy articles created by Polbot, All stub articles, Sapindales stubs). ...
Brucea javanica
"Brucea javanica (L.) Merr". The Plant List. Retrieved 20 March 2015. "Brucea javanica". Germplasm Resources Information Network ... Brucea javanica grows up as a shrub or small tree to 5 metres (20 ft) tall. The tiny flowers (1.5--2 mm in diameter) are ... Brucea javanica (also known as Macassar kernels) is a shrub in the family Simaroubaceae. The specific epithet javanica is from ... The fruit Brucea javanica was first written about as medicine in the Chinese medical monograph Omissions from the Grand Materia ...
Daniel Bruce (footballer, born 1868)
ISBN 978-1-899468-67-6. "Daniel Bruce - A Squad". Scottish Football Association. Archived from the original on 16 June 2011. " ...
Bruceanol
... s are quassinoids isolated from Brucea antidysenterica. Bruceanol A Bruceanol B Bruceanol C Bruceanol D Bruceanol E ... Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
Elwyn Welch
"Mt Bruce - a view from up above". Mt Bruce. Archived from the original on 16 July 2011. Retrieved 12 September 2012. (Articles ...
Bruceanol G
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol G is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
Bruceanol H
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol H is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ... "Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica". Journal of Natural Products. 58 (12): 1915-9. doi: ...
Bruceanol C
... , a new cytotoxic quassinoid from Brucea antidysenterica". Journal of Natural Products. 51 (2): 349-352. doi:10.1021 ... Bruceanol C is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceantin
... is a chemical compound that was first isolated from the plant Brucea antidysenterica in 1973. Chemically, it is ... F D Gillin, D S Reiner, M Suffness (2021). "Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica". ... a new potent antileukemic simaroubolide from Brucea antidysenterica". J. Org. Chem. 38 (1): 178-179. doi:10.1021/jo00941a049.{{ ...
Esther Bruce
"ESTHER BRUCE - A BLACK LONDON SEAMSTRESS: HER STORY 1912-1994". www.stephenbourne.co.uk. Retrieved 2017-10-25. "Putting Black ...
Bruceanol A
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol A is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol E
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol E is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol B
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol B is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol F
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol F is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
Bruceanol D
Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica". Journal of Natural Products. 48 (6): 972-5. ... Bruceanol D is a cytotoxic quassinoid isolated from Brucea antidysenterica with potential antitumor and antileukemic properties ...
List of vegetable oils
Brucea javanica oil, extracted from the seeds of the Brucea javanica. The oil has been shown to be effective in treating ... Zhang, Hong; Yang, Jing Yu; Zhou, Fan; Wang, Li Hui; Zhang, Wen; Sha, Sha; Wu, Chun Fu (2011). "Seed Oil of Brucea javanica ... Lou, Guo-Guang; Yao, Hang-Ping; Xie, Li-Ping (2010). "Brucea javanica Oil Induces Apoptosis in T24 Bladder Cancer Cells via ...
Race for the Yankee Zephyr
The Bartender (Robert Bruce) - A civilian and owner of a local bar. Tony Sparks Clark Walkington Frank Taurua Steve Nicolle ...
Bruceomyces
Brucea is the original name of Bruceomyces, published by Finnish mycologist Jouko Rikkinen in 2003. Rikkinen and colleagues ... renamed the genus in 2012 after it was discovered that Brucea was a junior homonym of a plant genus. The generic name honors ...
Leucopaxillus giganteus
... and Brucea abortus. Clitocine has also been shown to promote apoptosis (cell death) in human cervical cancer cells in vitro ( ...
Brucine
... is named from the genus Brucea, named after James Bruce who brought back Brucea antidysenterica from Ethiopia. Brucine ...
Simarouba
"Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of ...
Sharon Ann Hunt
Jamieson StuartW, Reitz BruceA, Oyer PhilipE, Billingham Margaret, Modry Dennis, Baldwin John, Stinson EdwardB, Hunt Sharon, ...
Inverkeithing
Walter Bruce-a known witch hunter-as minister of St Peter's. Bruce also played a pivotal role in initiating the so-called Great ...
List of endangered plants
pedicellata Species Bersama swynnertonii Bretschneidera sinensis Brucea macrocarpa Bulnesia carrapo Dipteronia dyeriana ...
Clan Campbell
This is partly explained by the loyalty of Sir Neil Campbell (Niall mac Caile), (d.1315), to the cause of Robert the Bruce - a ...
The Crooked Road (1911 film)
Dell Henderson - The Husband Stephanie Longfellow - The Wife Kate Bruce - A Neighbor William J. Butler - Pawnbroker Edward ...
1905 in Australian literature
A Tale of the Golden West Guy Boothby A Brighton Tragedy In Spite of the Czar The Stolen Peer Mary Grant Bruce - A Little Bush ...
List of MeSH codes (B06)
... brucea MeSH B06.388.100.898.333 - eurycoma MeSH B06.388.100.898.555 - picrasma MeSH B06.388.100.898.599 - quassia MeSH B06.388. ...
Bruceomycetaceae
Bruceomyces castoris was originally described by Rikkinen in 2003 as Brucea castoris, but was transferred to the newly ... circumscribed Bruceomyces in 2012 after it was discovered that Brucea was a junior homonym of a plant genus. The genus name ...
Nomad: Stopama Brucea Chatwina - Dokukino KIC - Kino sa stavom
RIP Col. Bruce - A Tribute to a Friend and Genius - Alan Paul
C-BRUCE-A
C-BRUCE-A
Womens Centre Grey Bruce - A Meandering Mann
I am very pleased to write and say that I have made donations to both the The Womens Centre Grey Bruce and to the David Suzuki Foundation, for those not Canadian David Suzuki is a long time environmental and climate change crusader. The donation, of over $100s comes from 10% of the sales I made during this year. Thank you for your purchases so that I can make these donations.. I chose these two organization for the following reasons:. Women have been very adversely affected by the Covid pandemic. They were trapped in abusive homes, and some were murdered. Many lost their jobs in the service and other sectors and the wage divide between men and women is reported to be widening. They are now talking about women not getting promoted as they may choose to work from home longer due to childcare responsibilities and will not make the contacts and be able to shine in person that encourages promotions. Very frustrating to see hard wins lost like this. Apart from this ongoing plague women are also ...
In Vitro Study of the Combination of Doxorubicin, Curcuma xanthorrhiza, Brucea javanica, and Ficus septica as a Potential Novel...
Curcuma xanthorrhiza, Brucea javanica, and Ficus septica may have potential to be developed as a combination with or without ... In Vitro Study of the Combination of Doxorubicin, Curcuma xanthorrhiza, Brucea javanica, and Ficus septica as a Potential Novel ... fruit of Brucea javanica (EBj), leave of Ficus septica (EFs) and doxorubicin (Dox) alone and its combination on migration and ...
Music Thursdays - American Swedish Institute
Review: When It Grows Dark (2017) by Jørn Lier Horst (trans: Anne Bruce) - A Crime is Afoot
OPTIMASI FORMULA SEDIAAN NANOEMULSI EKSTRAK BIJI WALI (Brucea javanica (L.) Merr) DENGAN METODE SIMPLEX LATTICE DESIGN -...
Biji buah wali (Brucea javanica (L.) Merr) merupakan bagian tanaman yang memiliki aktivitas antiinflamasi karena kandungannya ... OPTIMASI FORMULA SEDIAAN NANOEMULSI EKSTRAK BIJI WALI (Brucea javanica (L.) Merr) DENGAN METODE SIMPLEX LATTICE DESIGN ... BAIQ RIZKIA DWIYANA, MELIANDARI (2022) OPTIMASI FORMULA SEDIAAN NANOEMULSI EKSTRAK BIJI WALI (Brucea javanica (L.) Merr) DENGAN ...
Bruce A. Boston M.D. | Health care provider | OHSU
Dr. Boston specializes in caring for infants, children and adolescents with endocrine or hormone problems. These include problems with growth, puberty, thyroid, adrenal and any other disorder related to the hormone glands. Dr. Boston also treats both type 1 and type 2 diabetes in children. As a specialist in pediatric diabetes, Dr. Boston takes a developmental and family centered approach to the care of diabetes in children and adolescents. This approach requires multiple diabetes team members specially trained in the care of kids with diabetes. These pediatric diabetes team members are all available at the Harold Schnitzer Diabetes Health Center. Dr. Boston is also very involved with the Gales Creek Camp for Children with Diabetes that offers a summer camping experience for children with type 1 diabetes and their families.. In his spare time, Dr. Boston enjoys spending time staying in shape with a weekly soccer game. He also enjoys traveling with his family and getting away to the gorgeous ...
F i b r a
Simarouba glauca Paradise Tree, Bitterwood, Dysentery-bark PFAF Plant Database
Alkaline Diet Detox By OnCourse, LLC, USA
Mercurius Vivus relationships by Boericke - ABC Homeopathy
Bruce A. Dixon Archives - San Francisco Bay View
Since June 10 an undetermined number of Georgia prisoners have been on a hunger strike. Some of these men are the Jackson State prison strikers. After two weeks, according to the families of Miguel Jackson and Preston Whiting, they are weak from hunger and subject to fainting spells. But they seem to believe they have little to lose. They are, a letter from one of them asserts, "starving for change." We must demand justice for Miguel Jackson and other Georgia state prisoners who are being targeted and brutalized for exposing their inhumane conditions and standing up for their most basic human rights ...
Cate Blanchett - téma na Pravde
Bruce Alan Grandstaff | Vietnam War | U.S. Army | Medal of Honor Recipient
WMSE - 91.7FM
Cas 492-61-5|b-D-Glucopyranose|lookchem
How often are keyword rankings updated? | SEO Forum | Moz
Hedera Helix - ABC Homeopathy
Bruce A. Pasternack | InkWell Management Literary Agency
Simaroubaceae - efloraofindia
Batman Returns - Wikipedia
Contracts
brucea@dga.org Low Budget - LA, Barbara Berman (310) 289-2008. [email protected] ...
Buah Makassar | Project
Noah
Javanica6
- The aims of this study is to prove the inhibitory effect of ethanolic extract of rhizome of Curcuma xanthorrhiza (ECx), fruit of Brucea javanica (EBj), leave of Ficus septica (EFs) and doxorubicin (Dox) alone and its combination on migration and invasion of a highly metastatic 4T1 breast cancer cell line. (unej.ac.id)
- Curcuma xanthorrhiza, Brucea javanica, and Ficus septica may have potential to be developed as a combination with or without doxorubicin for metastatic breast cancer treatment. (unej.ac.id)
- Biji buah wali (Brucea javanica (L.) Merr) merupakan bagian tanaman yang memiliki aktivitas antiinflamasi karena kandungannya berupa senyawa fenolik dan triterpenoid. (unram.ac.id)
- Brucea javanica (L.) Merr. (google.com)
- Antidiabetic, antibacterial and antioxidant activities of different extracts from Brucea javanica (L.) Merr seeds. (ukrida.ac.id)
- Brusatol (Bru), a Chinese medicine Brucea javanica extract, has a variety of antitumour effects. (bvsalud.org)
Waynea1
- Vjerni batler Brucea Waynea. (wikipedia.org)
Antidysenterica1
- See Brucea antidysenterica. (dictionary.net)
Leeja1
- Prelomna kung fu klasika, ki je iz Brucea Leeja dokončno naredila legendo in kult tudi v Združenih državah Amerike. (siol.net)
Mollis2
- Brucea mollis WALL. (frlht.org)
- Chemical constituents from stems of Brucea mollis and their cytotoxic activity. (chemfaces.com)
Botnicka2
- Skupina teda prešla zvukovou a žánrovou premenou pod vplyvom producenta Electra records, Paul A. Rothchilda a zvukára Brucea Botnicka . (musicpress.sk)
- Poleg originalnega albuma, bo razširjena verzija ponatisa vsebovala remasteriziran zvok dolgoletnega zvočnega inženirja in producenta skupine Brucea Botnicka ter dodatno zgoščenko, zapolnjeno z doslej neizdanimi, drugačnimi verzijami skladb, ki so se beležile na snemalne trakove v času snemanja albuma. (rockline.si)
Nakon2
- Arthur odlazi do Wayne Manor, gdje susreće Thomasovog malog sina Brucea, ali bježi nakon svađe s obiteljskim bitkama Alfredom Pennyworthom. (instructure.com)
- Album je obilježio povratak pjevača Brucea Dickinsona nakon šest i gitarista Adriana Smitha nakon devet godina. (wikipedia.org)
Kris1
- Njihova majka je domaćica Kris, a djevojke imaju i najmlađeg brata Roberta Jr.. Međutim, Robert i Kris su se 1990.g. rastali, da bi se Kris samo godinu dana kasnije udala za Brucea Jennera, olimpijskog pobjednika u desetoboju 1976.g. u Montrealu i strastvenog motivacijskog govornika s kojim ima još dvije kćeri, Kendall i Kylie Jenner. (tvprofil.com)