Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Endoscopic examination, therapy or surgery of the bronchi.
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
Infection of the lung often accompanied by inflammation.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Pathological processes involving any part of the LUNG.
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Medical procedure involving the emptying of contents in the stomach through the use of a tube inserted through the nose or mouth. It is performed to remove poisons or relieve pressure due to intestinal blockages or during surgery.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Washing out of the peritoneal cavity. The procedure is a diagnostic as well as a therapeutic technique following abdominal trauma or inflammation.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A genus of ascomycetous FUNGI, family Pneumocystidaceae, order Pneumocystidales. It includes various host-specific species causing PNEUMOCYSTIS PNEUMONIA in humans and other MAMMALS.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
The transference of either one or both of the lungs from one human or animal to another.
Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
Inflammation of the lung parenchyma that is caused by a viral infection.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Quartz (SiO2). A glassy or crystalline form of silicon dioxide. Many colored varieties are semiprecious stones. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Compounds that accept electrons in an oxidation-reduction reaction. The reaction is induced by or accelerated by exposure to electromagnetic radiation in the spectrum of visible or ultraviolet light.
Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Endoscopes for the visualization of the interior of the bronchi.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Pneumonia due to aspiration or inhalation of various oily or fatty substances.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Delivery of medications through the nasal mucosa.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Inflammation of the BRONCHIOLES.
Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).
A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
A species of PNEUMOCYSTIS infecting humans and causing PNEUMOCYSTIS PNEUMONIA. It also occasionally causes extrapulmonary disease in immunocompromised patients. Its former name was Pneumocystis carinii f. sp. hominis.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.
Elements of limited time intervals, contributing to particular results or situations.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
The structural changes in the number, mass, size and/or composition of the airway tissues.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Mechanical devices used to produce or assist pulmonary ventilation.
A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.
Infections with fungi of the genus ASPERGILLUS.
Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
An abnormal increase in the amount of oxygen in the tissues and organs.
Liquid components of living organisms.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Inhaling and exhaling the smoke of burning TOBACCO.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Polysaccharides consisting of mannose units.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
Substances that reduce or suppress INFLAMMATION.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The technology of transmitting light over long distances through strands of glass or other transparent material.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
Infections with bacteria of the genus PSEUDOMONAS.
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.
A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.
Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
MYCOBACTERIUM infections of the lung.
A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Diseases of domestic and wild horses of the species Equus caballus.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Excess of normal lymphocytes in the blood or in any effusion.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
A form of pneumoconiosis caused by inhaled rare metal BERYLLIUM or its soluble salts which are used in a wide variety of industry including alloys, ceramics, radiographic equipment, and vacuum tubes. Berylliosis is characterized by an acute inflammatory reaction in the upper airway leading to BRONCHIOLITIS; PULMONARY EDEMA; and pneumonia.
Disease having a short and relatively severe course.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A classification of lymphocytes based on structurally or functionally different populations of cells.
Long, pliable, cohesive natural or manufactured filaments of various lengths. They form the structure of some minerals. The medical significance lies in their potential ability to cause various types of PNEUMOCONIOSIS (e.g., ASBESTOSIS) after occupational or environmental exposure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p708)
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Interstitial pneumonia caused by extensive infection of the lungs (LUNG) and BRONCHI, particularly the lower lobes of the lungs, by MYCOPLASMA PNEUMONIAE in humans. In SHEEP, it is caused by MYCOPLASMA OVIPNEUMONIAE. In CATTLE, it may be caused by MYCOPLASMA DISPAR.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Soluble mediators of the immune response that are neither antibodies nor complement. They are produced largely, but not exclusively, by monocytes and macrophages.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
Relating to the size of solids.
The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Short filamentous organism of the genus Mycoplasma, which binds firmly to the cells of the respiratory epithelium. It is one of the etiologic agents of non-viral primary atypical pneumonia in man.

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1/657)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen.  (+info)

Mushroom worker's lung resulting from indoor cultivation of Pleurotus osteatus. (2/657)

Indoor cultivation of oyster mushroom Pleurotus osteatus lead to an outbreak of extrinsic allergic alveolitis in two workers. High titer of indirect fluorescent antibody and positive precipitins against basidiospores of P. osteatus were demonstrated in sera of the patients. Mushroom workers should protect themselves from the basidiospores, being aware of their pathogenicity.  (+info)

RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques. (3/657)

Primary infection of macaques with pathogenic isolates of simian immunodeficiency virus (SIV) (as a model of HIV infection in humans) represents a unique opportunity to study early lentivirus/host interactions. We sought to determine whether there is a temporal relationship linking SIV replication and dissemination and the expression of the chemokine RANTES (regulated upon activation normal T cell expressed and secreted) and the SIV/HIV coreceptor CCR5 in different tissues during acute SIV infection of macaques. Four cynomolgus macaques were inoculated intravenously with a pathogenic primary isolate of SIVmac251. RT-PCR was used to monitor the expression of RANTES and CCR5 mRNA in fresh isolated mononuclear cells from blood, lymph node, and bronchoalveolar lavages. These expressions were compared to those of IFN-gamma as an indicator of the development of the immune response and to another receptor for RANTES, CCR1, which is not described as a coreceptor for SIV/HIV-1 entry. An enhancement of CCR1/CCR5 mRNA expression was noticed during primary SIVmac251 infection of macaques, mainly in tissue. In the three different compartments investigated, IFN-gamma and RANTES overexpression was noticed by the time of systemic viral replication containment. Our results put CCR5 and RANTES mRNA expression back in the context of inflammatory and immune responses to SIV primary infection.  (+info)

Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages. (4/657)

Cigarette smoking can impair pulmonary immune function, and hence influences the development of lung diseases. Interleukin-8 (IL-8) is a proinflammatory peptide and a potent chemotactic factor for neutrophils, and is produced by both immune and non-immune cells including monocytes and alveolar macrophages (AM). We investigated the effect of cigarette smoking on the secretion of IL-8 by human AM. The IL-8 concentration in bronchoalveolar lavage fluid (BALF) was much higher in smokers than in non-smokers (18.4 +/- 3.9 vs 4.1 +/- 1.0 pg ml-1; P < 0.005). However, spontaneous IL-8 secretion by cultured AM was lower in smokers than in non-smokers (46.8 +/- 12.7 vs 124.1 +/- 24.0 ng ml-1; P < 0.01). When stimulated with lipopolysaccharide (LPS), AM from smokers secreted significantly less IL-8 than those from non-smokers at all tested concentrations of LPS. In contrast, the amount of IL-8 secreted by peripheral blood monocytes with or without LPS stimulation was comparable in smokers and non-smokers. These observations indicate that smoking decreases IL-8 secretion by AM, which may modify or decrease the inflammatory response in the lung.  (+info)

Pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia. (5/657)

We describe the case of a 53-year-old Philadelphia-chromosome-positive woman with chronic myelogenous leukemia, who developed pulmonary alveolar proteinosis (PAP). The possible mechanism involved in the pathogenesis of PAP are discussed based on the clinical and laboratory data for this patient as well as on experimental and clinical data reported in the literature.  (+info)

Role of pleural lavage cytology before resection for primary lung carcinoma. (6/657)

OBJECTIVE: To investigate the role of pleural lavage cytology (PLC) in resection for primary lung carcinoma. SUMMARY BACKGROUND DATA: The prognostic significance of PLC before manipulation is still controversial. METHODS: Cytology of pleural lavage immediately after thoracotomy but before any manipulation of the lung was examined in 500 consecutive patients with lung cancer with no pleural effusion who underwent pulmonary resections. Eighteen patients who already had pleural dissemination were excluded from this study. RESULTS: Eighteen of 482 patients (3.7%) had positive cytologic findings. The positivity of PLC was significantly correlated with histology, extension of tumor to pleura, and presence of lymphatic permeation or vascular involvement by tumor. Positive lavage findings were seen only in adenocarcinoma. Because 6.3% of the patients with adenocarcinoma had positive cytologic findings, it is vital to perform PLC before curative resections for lung cancer, especially adenocarcinoma. The 5-year survival rates of the patients having negative and positive lavage findings were 52.9% and 14.6%, respectively. The prognosis of the patients with positive lavage findings was as poor as that of the patients with stage IIIB disease and that of the patients with malignant effusion. CONCLUSIONS: Positive findings on PLC indicate exfoliation of cancer cells into the pleural cavity, which is an essential prognostic factor. In addition, we should regard positive cytologic findings as a subclinical malignant pleural effusion that is pathologic stage T4.  (+info)

Comparison of exogenous surfactant therapy, mechanical ventilation with high end-expiratory pressure and partial liquid ventilation in a model of acute lung injury. (7/657)

We have compared three treatment strategies, that aim to prevent repetitive alveolar collapse, for their effect on gas exchange, lung mechanics, lung injury, protein transfer into the alveoli and surfactant system, in a model of acute lung injury. In adult rats, the lungs were ventilated mechanically with 100% oxygen and a PEEP of 6 cm H2O, and acute lung injury was induced by repeated lung lavage to obtain a PaO2 value < 13 kPa. Animals were then allocated randomly (n = 12 in each group) to receive exogenous surfactant therapy, ventilation with high PEEP (18 cm H2O), partial liquid ventilation or ventilation with low PEEP (8 cm H2O) (ventilated controls). Blood-gas values were measured hourly. At the end of the 4-h study, in six animals per group, pressure-volume curves were constructed and bronchoalveolar lavage (BAL) was performed, whereas in the remaining animals lung injury was assessed. In the ventilated control group, arterial oxygenation did not improve and protein concentration of BAL and conversion of active to non-active surfactant components increased significantly. In the three treatment groups, PaO2 increased rapidly to > 50 kPa and remained stable over the next 4 h. The protein concentration of BAL fluid increased significantly only in the partial liquid ventilation group. Conversion of active to non-active surfactant components increased significantly in the partial liquid ventilation group and in the group ventilated with high PEEP. In the surfactant group and partial liquid ventilation groups, less lung injury was found compared with the ventilated control group and the group ventilated with high PEEP. We conclude that although all three strategies improved PaO2 to > 50 kPa, the impact on protein transfer into the alveoli, surfactant system and lung injury differed markedly.  (+info)

Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit. (8/657)

Nasal vaccine delivery is superior to oral delivery in inducing specific immunoglobulin A (IgA) and IgG antibody responses in the upper respiratory tract. Although an antibody response in the nasal passages is important in protecting against primary colonization with lung pathogens, antibodies in the lungs are usually required as well. We immunized 15 male volunteers twice nasally or orally with cholera toxin B subunit (CTB) and determined the specific antibody levels in serum, bronchoalveolar lavage (BAL) fluid, and urine before and 2 weeks after immunization. Nasal immunization induced fivefold increases in the levels of specific IgA antibodies in BAL fluid of most volunteers, whereas there were no significant specific IgA responses after oral immunization. The specific IgG antibody level increased eightfold in BAL fluid in the nasally vaccinated subjects, and the major part of IgG had most probably been transferred from serum. Since the specific IgG response in serum was lower in the individuals vaccinated orally, the IgG response in BAL fluid in this group was also lower and not significant. In conclusion, nasal immunization is also preferable to the oral route when vaccinating against lower respiratory tract infections, and a systemic immune response is considerably more important in the lower than in the upper respiratory tract. Moreover, both nasal and oral immunizations were able to stimulate 6- to 10-fold specific IgA and IgG responses in urine in about half of the individuals, which indicates that distant mucosal vaccination might be used to prevent adhesion of pathogens to the urogenital tract.  (+info)

Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by diffuse alveolar accumulation of surfactant proteins and phospholipids. Pulmonary alveolar proteinosis occurs four times more frequently in males than females, most commonly in those 20-50 years of age, and is marked by dyspnea and a typically nonproductive cough. Pulmonary alveolar proteinosis may be idiopathic (primary), associated with lung infections, malignant neoplasms, AIDS, or secondary to inhalation of foreign materials, including insecticides, silica, aluminum, titanium oxide and indium-tin oxide. A neonatal form has been observed in infants with a genetic deficiency of surfactant-associated protein B (SP-B ...
Introduction: Pulmonary alveolar proteinosis (PAP) is a rare disease characterised by the abnormal accumulation of surfactant-like material in macrophages within the alveolar spaces and distal bronchioles. The course of the disease is variable and the prognosis is often good. However, progressive disease in some patients can cause respiratory dysfunction and can be life threatening. In this situation, the only effective treatment is whole lung lavage. The objective of the study was to present the characteristics and the course of pulmonary alveolar proteinosis in our own material, the diagnostic methods used, the indications for treatment and the treatment efficacy.. Material and methods: Retrospective analysis included 17 patients: 6 women and 11 men, aged from 32 to 56 years, who were observed in the Third Lung Department of Pneumonology at the National Institute of Tuberculosis and Lung Diseases between 1984 and 2013. In all patients chest X-ray, pulmonary function test and blood gases were ...
As a rare procedure, massive bronchoalveolar lavage (MBAL) is a large-volume lavage which necessitates general anesthesia and one-lung ventilation (OLV). During MBAL isotonic saline is instilled into one lung and drained through one lumen of a double-lumen tube. MBAL is the most effective treatment for symptomatic pulmonary alveolar proteinosis (PAP). A 27-year-old male with PAP was scheduled for therapeutic MBALs. After standard preoxygenation, monitoring and anesthesia induction, a double-lumen tube was placed. Tube position was verified by a fiberoptic bronchoscope. The internal jugular vein, radial and pulmonary arteries were cannulated. A temperature probe and foley catheter were inserted. The nonventilated lung was filled with 1000 mL saline and then drained in each session. The left and right lung were lavaged with an interval of 2 weeks. A total of 20 L saline was used in each MBAL without retention. MBALs were terminated after the effluent became clear. Duration of the left and right ...
The trial is a randomised, double-blind, placebo-controlled multicentre clinical trial investigating efficacy and safety of inhaled molgramostim (rhGM-CSF) in autoimmune pulmonary alveolar proteinosis (aPAP) patients.. The primary objective is efficacy on the Alveolar-arterial oxygen difference after 24-weeks treatment. Secondary objectives are tolerance to exercise, effect on Quality of Life, time to Whole Lung Lavage (WLL), effect on pulmonary function, effect on dyspnea and cough, and effect on computed tomography (CT) scoring. Number of reported adverse events (AEs), serious AEs, and adverse drug reactions will be monitored.. The trial will include two phases; a Double-blind treatment period consisting of up to eight trial visits (Screening, Baseline, and at Weeks 4,8,12, 16, 20 and 24 after randomisation) and a Follow-up period consisting of up to five trial visits (at Weeks 4, 12, 24, 36 and 48 post-treatment).. In the Double-blind treatment period, eligible subjects will be randomised to ...
Pulmonary alveolar proteinosis (PAP) is a syndrome characterised by respiratory failure caused by pulmonary surfactant accumulation and resulting in respiratory insuiciency and an increased incidence of infections.[1] The current standard therapy is whole-lung lavage, which is used to physically remove the accumulated surfactant.[2] PAP can be grouped into distinct categories based on clinical, histopathological, biochemical and genetic data.[3]. Surfactant homeostasis is critical for lung function and is tightly regulated, in part by pulmonary granulocyte-macrophage colony-stimulating factor (GM-CSF), which is required for surfactant clearance by alveolar macrophages and alveolar macrophage maturation[4] The effects of GM-CSF are mediated by cell-surface receptors composed of GM-CSF-binding a-chains and affinity-enhancing β-chains (encoded by CSF2RA and CSF2RB, respectively)[4] Primary PAP occurs when GM-CSF signalling is disrupted[3] either on an auto-immune basis, where high levels of ...
Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome caused by the accumulation of surfactants in the alveoli. The most prevalent clinical form of PAP is autoimmune PAP (aPAP) whereby IgG autoantibodies neutralize GM-CSF. GM-CSF is a pleiotropic cytokine that promotes the differentiation, survival, and activation of alveolar macrophages, the cells responsible for surfactant degradation. IgG-mediated neutralization of GM-CSF thereby inhibits alveolar macrophage homeostasis and function, leading to surfactant accumulation and innate immunodeficiency. Importantly, there are no rodent models for this disease; therefore, underlying immune mechanisms regulating GM-CSF-specific IgG in aPAP are not well understood. In this article, we identify that autoimmune-prone Rasgrp1-deficient mice develop aPAP: 1) Rasgrp1-deficient mice exhibit reduced pulmonary compliance and lung histopathology characteristic of PAP; 2) alveolar macrophages from Rasgrp1-deficient mice are enlarged and exhibit reduced ...
A 40-year-old mother of seven who did not smoke developed progressive dyspnoea that had persisted for 6 months. She was diagnosed with PAP in another hospital in 2005 by bronchoalveolar lavage and transbronchial biopsy. There she was treated with three whole lung lavages. When she arrived at our institution she was dyspnoeic at rest, her room air saturation was 84%, requiring 3 l of oxygen via nasal cannula. She underwent whole lung lavages in July and November 2005 and her saturation improved to 89-95% on room air during rest and 87% during effort; 0.5-1 l oxygen was administered via a nasal cannula.. At the beginning of January 2006, 5 mg/kg GM-CSF (Leukine; Bayer Healthcare Pharmaceuticals Inc, Leverkusen, Germany) was administered daily. Some improvement (better oxygenation and lung function tests) was demonstrated clinically, but there was no radiographic improvement.. A year later her dyspnoea increased and increasing amounts of supplemental oxygen were required. By February 2007 her ...
Download Free Full-Text of an article MYCOLOGICAL MICROSCOPIC AND CULTURE EXAMINATION OF 400 BRONCHOALVEOLAR LAVAGE (BAL) SAMPLES
Fingerprint Dive into the research topics of Phenotypic expression of bronchoalveolar lavage cells in lung rejection and infection. Together they form a unique fingerprint. ...
Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients peripheral blood. ...
PAN Czytelnia Czasopism, Cytological evaluation of tracheal aspirate and broncho-alveolar lavage fluid in comparison to endoscopic assessment of lower airways in horses with recurrent airways obstruction or inflammatory airway disease - Polish Journal of Veterinary Sciences
CASE REPORT. A 53 year old Negro man was admitted to the Orange Memorial Hospital on January 13, 1958. For the preceding six months he had noted mild exertional dyspnea, and a cough productive of moderate amounts of white sputum. He attributed these symptoms to the fracture of a left rib in July, 1957. In November, 1957, he developed symptoms and signs of a ...
C Ward, Kelly CA, Stenton SC, M Duddridge, Hendrick DJ, Walters EH; Macrophage (AM) and Neutrophil (PMNL) Chemiliuminescence (CL) in Bronchoalveolar Lavage (BAL) Fluid. Clin Sci (Lond) 1 December 1987; 73 (s17): 33P-34P. doi: https://doi.org/10.1042/cs073033Pc. Download citation file:. ...
TY - JOUR. T1 - Bronchoalveolar lavage in the study of asthma. AU - Rennard, S. I.. AU - Thompson, A. B.. AU - Floreani, A. A.. PY - 1992. Y1 - 1992. UR - http://www.scopus.com/inward/record.url?scp=0026770648&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026770648&partnerID=8YFLogxK. U2 - 10.1378/chest.102.1.1. DO - 10.1378/chest.102.1.1. M3 - Editorial. C2 - 1623734. AN - SCOPUS:0026770648. VL - 102. SP - 1. EP - 2. JO - Chest. JF - Chest. SN - 0012-3692. IS - 1. ER - ...
To transport BAL samples from the field, pour samples into EDTA tubes or dilute 50:50 with grain alcohol or Vodka (100 Proof) and transport in clot tubes. Dont drink and drive! ...
Also known as: bal, Bal., Bal, BaL, Ba.L, Ba-L. An, Ba-L, BA¶l, BAl, BAL., BAL, BA-L, B=Al, B.A.L., B.A.L, B. A. L., B-aL, B-AL ...
Looking for online definition of pulmonary alveolar proteinosis in the Medical Dictionary? pulmonary alveolar proteinosis explanation free. What is pulmonary alveolar proteinosis? Meaning of pulmonary alveolar proteinosis medical term. What does pulmonary alveolar proteinosis mean?
Pulmonary alveolar proteinosis (PAP) is a syndrome characterised by respiratory failure caused by pulmonary surfactant accumulation and resulting in respiratory insuiciency and an increased incidence of infections.[1] The current standard therapy is whole-lung lavage, which is used to physically remove the accumulated surfactant.[2] PAP can be grouped into distinct categories based on clinical, histopathological, biochemical and genetic data.[3]. Surfactant homeostasis is critical for lung function and is tightly regulated, in part by pulmonary granulocyte-macrophage colony-stimulating factor (GM-CSF), which is required for surfactant clearance by alveolar macrophages and alveolar macrophage maturation[4] The effects of GM-CSF are mediated by cell-surface receptors composed of GM-CSF-binding a-chains and affinity-enhancing β-chains (encoded by CSF2RA and CSF2RB, respectively)[4] Primary PAP occurs when GM-CSF signalling is disrupted[3] either on an auto-immune basis, where high levels of ...
Secondary pulmonary alveolar proteinosis predominant in the transplanted lung in patients with idiopathic interstitial pneumonia: an autopsy case
Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which an abnormal accumulation of pulmonary surfactant occurs within the alveoli (microscopic air sacs in the lung), interfering with the lungs ability to exchange oxygen from the air, and carbon dioxide from the blood. PAP can occur in a primary form or secondarily in the settings of certain cancers (such as myeloid leukemia), lung infections, or environmental exposure to dusts or chemicals. Rare familial forms have also been recognized, suggesting a genetic component in those cases. The signs and symptoms of PAP include shortness of breath, a cough, low grade fever, and weight loss. The clinical course of PAP is unpredictable. Spontaneous remission is recognized, and some patients have stable symptoms. Death may occur due to the progression of PAP or of any underlying associated disease. Individuals with PAP are more vulnerable to lung infections such as bacterial pneumonia, mycobacterium avium-intracellulare infection, or a ...
As emphasized above, WLL is the current standard of care for autoimmune and other forms of PAP[6]. As shown in Table 4, the procedure was adopted in 54% of PAP patients in the Seymour study, data are in line with the Seymour and Chinese series, with 54% of PAP patients submitted to WLL. Twenty-nine out of our 73 patients were never submitted to WLL during their follow up. No patient refused the treatment; the decision was based on medical evaluation, since the degree of lung involvement did not alter the lung function. In other words, in these patients the WLL, an invasive and potentially harmful procedure, was considered unnecessary. Of the 44 patients in our series submitted to WLL, in 31 (70%), a single WLL was sufficient to ensure long-term, durable benefit in lung function. Such a benefit, of course, does not exclude disease relapse, but not to such a severe degree requiring an additional WLL. It is noteworthy, that among the 31 PAP patients lavaged only once, included are 3 PAP patients ...
Free, official info about 2015 ICD-9-CM diagnosis code 516.0. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
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TY - JOUR. T1 - Novel approach for analysis of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS-based lipidomics. T2 - Lipid levels in asthmatics and corticosteroid-treated asthmatic patients. AU - Kang, Yun Pyo. AU - Lee, Won Jun. AU - Hong, Ji Yeon. AU - Lee, Sae Bom. AU - Park, Jeong Hill. AU - Kim, Donghak. AU - Park, Sunghyouk. AU - Park, Choon Sik. AU - Park, Sung Woo. AU - Kwon, Sung Won. PY - 2014/9/5. Y1 - 2014/9/5. N2 - To better understand the respiratory lipid phenotypes of asthma, we developed a novel method for lipid profiling of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS with an internal spectral library and high-throughput lipid-identifying software. The method was applied to BALF from 38 asthmatic patients (18 patients with nonsteroid treated bronchial asthma [NSBA] and 20 patients with steroid treated bronchial asthma [SBA]) and 13 healthy subjects (NC). We identified 69 lipids, which were categorized into one of six lipid classes: lysophosphatidylcholine ...
A P Greening, N C Dobson, P Nunn, A D M Rees; Bronchoalveolar Lavage in Fibrosing Alveolitis Assessment of Lymphocyte Proportions, Subtypes and Function. Clin Sci (Lond) 1 February 1984; 66 (2): 55P. doi: https://doi.org/10.1042/cs066055P_pt2. Download citation file:. ...
Tazawa R, Ueda T, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Oda M, Ishii H, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Sakagami T, Hashimoto A, Tanaka T, Takada T, Mikami A, Kitamura N, Nakata K. Inhaled GM-CSF for Pulmonary Alveolar Proteinosis. N Engl J Med. 2019 09 05; 381(10):923-932 ...
1. In patients with pulmonary alveolar proteinosis, use of twice daily inhaled granulocyte-macrophage colony-stimulating factor (GM-CSF) did not improve
Cytokine Levels In Bronchoalveolar Lavage Fluid (Balf) In Patients With Systemic Sclerosis (SSc). In comparison to other diseases, SSc patients present a spe...
TY - JOUR. T1 - Endothelin-1 in bronchoalveolar lavage during rejection of allotransplanted lungs. AU - Schersten, Henrik. AU - Aarnio, Pertti. AU - Burnett, John C.. AU - McGregor, Christopher G.A.. AU - Miller, Virginia M.. PY - 1994/1. Y1 - 1994/1. UR - http://www.scopus.com/inward/record.url?scp=0028107330&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028107330&partnerID=8YFLogxK. U2 - 10.1097/00007890-199401000-00027. DO - 10.1097/00007890-199401000-00027. M3 - Article. C2 - 8291104. AN - SCOPUS:0028107330. VL - 57. SP - 159. EP - 161. JO - Transplantation. JF - Transplantation. SN - 0041-1337. IS - 1. ER - ...
Fingerprint Dive into the research topics of Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. Together they form a unique fingerprint. ...
Results C57 mice demonstrated a higher total bronchoalveolar lavage (BAL) and BAL lymphocyte count at 3 and 7 days after intraperitoneal infection compared with BALB mice. There were no differences in BAL cytokine production; however, we were able to demonstrate differences in CMV DNA load in the lungs of BALB mice compared with that of C57 mice. In addition, there appeared to be increased whole-lung production of the TH2 cytokine IL-10 in the BALB mice versus the C57 mice. ...
BACKGROUND: The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant literature on BAL in ILD and provide recommendations concerning the use of BAL in the diagnosis and management of patients with suspected ILD. PURPOSE: To provide recommendations for (1) the performance and processing of BAL and (2) the interpretation of BAL nucleated immune cell patterns and other BAL characteristics in patients with suspected ILD ...
The paper is concerned with the description of clinical, x-ray and morphological investigation of 123 bronchoalveolar cancer patients. Three types of this disease were defined: nodular (homogeneous and nonhomogeneous), pneumonia-like (infiltrative and infiltrative-nodular) and mixed (focal-disseminated, focal-nodular and focal-infiltrative). These types of bronchoalveolar cancer are most probably stages of the same tumor process. Clinical and x-ray signs of each type showed correlation with a morphological picture of a tumor. Shadow nonhomogeneity as one of the main x-ray signs of bronchoalveolar cancer was shown to be determined by the alveolar structure of a tumor, a tendency to the formation of small cavities, filled with viscous mucosa and air. Correct clinical and x-ray diagnosis in all types of bronchoalveolar cancer (before the use of the morphological methods) was established in 45.5% of the patients ...
The paper is concerned with the description of clinical, x-ray and morphological investigation of 123 bronchoalveolar cancer patients. Three types of this disease were defined: nodular (homogeneous and nonhomogeneous), pneumonia-like (infiltrative and infiltrative-nodular) and mixed (focal-disseminated, focal-nodular and focal-infiltrative). These types of bronchoalveolar cancer are most probably stages of the same tumor process. Clinical and x-ray signs of each type showed correlation with a morphological picture of a tumor. Shadow nonhomogeneity as one of the main x-ray signs of bronchoalveolar cancer was shown to be determined by the alveolar structure of a tumor, a tendency to the formation of small cavities, filled with viscous mucosa and air. Correct clinical and x-ray diagnosis in all types of bronchoalveolar cancer (before the use of the morphological methods) was established in 45.5% of the patients ...
HIA has previously discussed the coding of bronchoscopy with bronchoalveolar lavage (BAL). The coding of procedures performed via bronchoscopy has become complicated in ICD-10-PCS. The coder must now think about the objective of the procedure to assign the correct root operation, the correct body part being addressed, and the correct approach and whether or not the intent of any removal of tissue or fluid was diagnostic.. Read More ...
Confused on this one. Inpatient visist: When a Intensivist does a procedure of BAL Lavage and its done on both lungs. Is this report twice with CPT 3
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Hľadali ste balíky ktorých názvy obsahujú ruby-cocaine v sady bionic-updates, všetky sekcie a architektúry ppc64el. Ľutujeme hľadané kľúčové slová nevrátili žiadne výsledky. ...
Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have
Sixty seven patients with biopsy proven pulmonary sarcoidosis were prospectively studied to determine whether single point bronchoalveolar lavage cell counts were a useful indicator of functional outcome and whether repeated lavage helped in management. The mean follow up period was 25 (range 13-37) months. No patient was having corticosteroid treatment at the time of initial bronchoalveolar lavage. High intensity alveolitis (lymphocyte count greater than or equal to 28%) was present at the initial lavage in 42 patients. These patients showed a significant improvement in their pulmonary function and chest radiographs over the follow up period whereas patients with low intensity alveolitis did not. Of the 42 patients with high intensity alveolitis, 31 had chronic sarcoidosis (duration over two years, mean 80 months). These patients showed a significant improvement in FVC but not in TLCO. Corticosteroids resulted in greater functional and radiological improvement in the patients with high ...
Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposits of acellular amorphous material of uncertain nature in a relatively large series of 227 BAL samples obtained from patients with various ILDs. Overall, eosinophilic globules were detected in 18 cases (7.9%), 16 of which were in patients with systemic sclerosis (SSc)-related ILD (16/50 [32%]) and in 2 cases of apparently idiopathic usual interstitial pneumonia. Apart from the possible diagnostic information of this finding, in patients with SSc, the globules were significantly related to BAL neutrophilia or eosinophilia and extensive ILD in high-resolution computed tomography (P , .0001). Differential diagnosis with other types of acellular globular materials observed in BAL ...
Bronchoscopy with bronchoalveolar lavage. Refractory pneumonitis. A 69-year-old man status post trauma, slightly prolonged respiratory failure status post tracheostomy, requires another bronchoscopy for further evaluation of refractory pneumonitis.
Objective: Due to a outbreak of silica-related autoimmune disease in synthetic stone construction, we found an opportunity to characterize the rheumatologic complications in silicosis within these highly exposed patients.. Methods: We reviewed data from all cases of silicosis due to synthetic stone dust referred for lung transplant assessment. In addition to silicosis-specific data, we extracted data relevant to the manifestations of autoimmune diseases in these patients.. Results: Of 40 patients in our silicosis cohort, we identified nine (22.5%) with findings consistent with various autoimmune disease. Among these nine, three also had findings suggestive of pulmonary alveolar proteinosis. Based on an expected autoimmune disease prevalence of 3% ( European international data), the proportion of disease in our group represents a more than seven-fold excess (prevalence ratio [PR] 7.5; 99% CI 2.6 to 16.7). ...
A 35-year-old woman is admitted with history of worsening left-sided weakness, multiple falls and finally inability to walk because of her weakness. She had headaches which were getting worse and associated with nausea. She had a past medical history of diabetes mellitus type 2, had undergone a hysterectomy a few years earlier for cervical cancer, and also had been diagnosed with pulmonary alveolar proteinosis (PAP). She lived with her husband, had no children, and reported a 20-year, 2-packs-per-day smoking history, but had recently cut down to 1 pack per day. She denied any alcohol or illicit drug use. Testing showed she was HIV-negative. Toxoplasma immunoglobulin (Ig)M and IgG were negative. Routine blood cultures were negative ...
Predicted to have cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Is expressed in early conceptus and embryo. Orthologous to human CSF2RB (colony stimulating factor 2 receptor beta common subunit ...
Cytology, Bronchoalveolar Lavage 2,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
BAL specimens were initially introduced as a therapeutic procedure for removal of the alveolar spaces of accumulated secretions for cases of alveolar proteinosis and bronchial asthma. Subsequently, it has been used for cases of sarcoidosis and pulmonary fibrosis. Most recently it has been used for the identification of organisms such as Pneumocystis carinii and bacterial and viral agents causing pulmonary infections in individuals afflicted with the acquired immunodeficiency syndrome (AIDS ...
bronchoalveolar definition: Adjective (comparative more bronchoalveolar, superlative most bronchoalveolar) 1. Relating to both the bronchi and the alvioli of the lungs...
Endoscopy may be recommended- this is when we place a camera down into the airway and we can visualise for any signs of infection. We are also then able to take samples (tracheal wash and broncho-alveolar lavage) from the airway to confirm if your horse is suffering from asthma and whether any secondary infections are present ...
Speciman preparation for microscope slide EAnimals plants etc. MeCan provide best online selection of quality specimens for microscope observation.
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AlphaLISA no-wash assay kit for detection and quantitation of Mouse/Rat C-C Motif Chemokine 5 / Regulated Upon Activation Normal T-Cell Expressed, and Secreted (CCL5/RANTES) in serum, bronchial lavage fluid (BALF), buffered solution or cell culture medium.
Webley WC, Salva PS, Andrzejewski C, Cirino F, West CA, Tilahun Y, Stuart ES. 2005. The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia.. Am J Respir Crit Care Med. 171(10):1083-8. ...
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Bronchoalveolar lavage[edit]. Bronchoalveolar lavage (BAL) is a procedure whereby a small volume of fluid is put into the ... Cytopathology (examination under a microscope) of either a tracheal wash or a bronchoalveolar lavage sample can determine ... McKane, SA; Rose, RJ (10 June 2010). "Effects of exercise intensity and training on bronchoalveolar lavage cytology". Equine ... EIPH in the small airways may still be present and can be confirmed by a bronchoalveolar lavage. Impaired arterial blood gas ( ...
"American Thoracic Society - Bronchoalveolar Lavage". American Thoracic Society. Retrieved 8 September 2019. K.N. Priftis; M.B. ... Lipid-laden alveolar macrophages, also known as pulmonary foam cells, are cells found in bronchoalveolar lavage (BAL) specimens ... Sacco, Oliviero; Fregonese, B.; Silvestri, M.; Sabatini, F.; Mattioli, G.; Rossi, G.A. (2000). "Bronchoalveolar lavage and ... "Bronchoalveolar lavage - indications and application". Paediatric Bronchoscopy. Karger Medical and Scientific Publishers. p. 38 ...
... by bronchoalveolar macrophages isolated from human bronchoalveolar lavage washings; and by the human H295R adrenocortical cell ... and that 5-oxo-ETE is present in the bronchoalveolar lavage fluid from cats with experimentally induced asthma; these findings ...
Some lacritin was reported in lung bronchoalveolar lavage and plasma. In lacrimal gland, polarized lacrimal acinar cells appear ... Lacritin is a glycoprotein of the human tear film, and to a lesser extent of saliva, lung lavage and plasma. It is mainly ...
"Mycoplasma alkalescens demonstrated in bronchoalveolar lavage of cattle in Denmark". Acta Veterinaria Scandinavica. 49 (1): 2. ...
Comparison of Biomarkers in Exhaled Breath Condensate and Bronchoalveolar Lavage. Am. J. Respir. Crit. Care Med. 2007; 175(3): ... that is a problem with all methods of sampling the airway and lungs including sputum collection and bronchoalveolar lavage. ...
"Costs of Bronchoalveolar Lavage-Directed Therapy in the First 5 Years of Life for Children with Cystic Fibrosis". Journal of ... "Effect of Bronchoalveolar Lavage-directed Therapy on Pseudomonas Aeruginosa Infection and Structural Lung Injury in Children ... "Safety of Bronchoalveolar Lavage in Young Children with Cystic Fibrosis". Pediatric Pulmonology. 43 (10): 965-72. doi:10.1002/ ... "Comparison of DNA Extraction Methods for Microbial Community Profiling with an Application to Pediatric Bronchoalveolar Lavage ...
"Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI". New England Journal of Medicine. 382 (8): 697-705. ...
Samples from bronchoalveolar lavage fluid specimens returned the highest sensitivity. The authors argued that CT scans showed ...
Bronchoalveolar lavage (BAL) is a well-tolerated diagnostic procedure in ILD. BAL cytology analyses (differential cell counts) ... Ohshimo S, Bonella F, Cui A, Beume M, Kohno N, Guzman J, Costabel U (2009). "Significance of bronchoalveolar lavage for the ...
C. acnes can be found in bronchoalveolar lavage of approximately 70% of patients with sarcoidosis and is associated with ... "Propionibacterium acnes DNA detected in bronchoalveolar lavage cells from patients with sarcoidosis". Sarcoidosis, Vasculitis, ...
Histopathology of lung biopsy or bronchoalveolar lavage may indicate lipid-laden macrophages. Laboratory results may show ...
Inhaled pentamidine is mainly deposited into the bronchoalveolar lavage fluid of the lungs. Metabolism: Pentamidine is ... When inhaled through a nebulizer, pentamidine accumulates in the bronchoalveolar fluid of the lungs at a higher concentration ...
The genome of P. jirovecii has been sequenced from a bronchoalveolar lavage sample. The genome is small, low in G+C content, ... "De Novo Assembly of the Pneumocystis jirovecii Genome from a Single Bronchoalveolar Lavage Fluid Specimen from a Patient". mBio ...
... it is present in bronchoalveolar lavage fluid from cats undergoing experimentally induced asthma; it stimulates the local ...
These other tests may include basic blood work, blood cultures, and bronchoalveolar lavage.[citation needed] The clinical ...
Samitas K, Zervas E, Xanthou G, Panoutsakopoulou V, Gaga M (Feb 2013). "Osteopontin is increased in the bronchoalveolar lavage ...
"Effect of Location, PH, and Temperature of Instillate in Bronchoalveolar Lavage in Normal Volunteers." ATSJournals (1983): n. ... "First Report of Isolation of Mycobacterium Elephantis from Bronchial Lavage of a Patient in Asia." JRSM Short Reports 2.4 (2011 ... but the testing of the patient's bronchial lavage found coccobacillary, acid-fast microbes. After further testing, the isolate ...
2001). "Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases". ...
The sample types were bronchoalveolar lavage (BAL) fluid samples (fluid samples collected from the lungs). The chemical was ...
The most suitable specimens are the sputum, or when clinically necessary, bronchoalveolar lavage or biopsy. Further biochemical ...
... diagnosis by sputum and bronchoalveolar lavage". Southern Medical Journal. 83 (10): 1226-9. doi:10.1097/00007611-199010000- ...
Trough insulin levels in bronchoalveolar lavage following inhaled human insulin (Exubera®) in patients with diabetes mellitus. ...
Allergen inhalation challenge of humans produces rises in the PGD2 levels in their Bronchoalveolar lavage fluids. Furthermore, ...
Wattiez R, Hermans C, Bernard A, Lesur O, Falmagne P (June 1999). "Human bronchoalveolar lavage fluid: two-dimensional gel ...
Bronchoalveolar Lavage (BAL) findings coinciding with pneumonitis typically include a lymphocytosis with a low CD4:CD8 ratio. ... consistent with pneumonitis Bronchoalveolar lavage with lymphocytosis Lung biopsy consistent with pneumonitis histopathology ... bronchoalveolar allergic syndrome) Mercury exposure Smoking Overexposure to chlorine Bronchial obstruction (obstructive ...
Often cultures from bronchoalveolar lavage and blood may be done for identification of the causative organism(s). It is ...
Typical inclusions called "Leventhal-Cole-Lillie bodies" can be seen within macrophages in BAL (bronchoalveolar lavage) fluid. ...
"Utility of reflex gomori methenamine silver staining for Pneumocystis jirovecii on bronchoalveolar lavage cytologic specimens: ...
Cytopathology may detect atypical cells from cytologic smear test of sputum, bronchoalveolar lavage, or samples from ...
Bronchoalveolar lavage. Respiratory therapy/. intubation. *Artificial respiration. *CPR. *Hyperbaric medicine. *Decompression ...
... to the overall abnormal airway epithelial damage and there is a significant correlation between RL and bronchoalveolar lavage ...
Moreover, the CASS4 mRNA was upregulated in cells collected by bronchoalveolar lavage after segmental broncho-provocation with ...
"Exuberant Plasmocytosis in Bronchoalveolar Lavage Specimen of the First Patient Requiring Extracorporeal Membrane Oxygenation ...
Protracted bacterial bronchitis is defined as a chronic productive cough with a positive bronchoalveolar lavage that resolves ...
Bronchoalveolar lavage. *Nasopharyngeal swab. *Sputum culture. Respiratory therapy/. intubation. *Artificial respiration. *CPR ...
... bronchoalveolar lavage fluid of BAL) and human eosinophils, which are implicated in contributing to human asthma, metabolize ...
"Exuberant plasmocytosis in bronchoalveolar lavage of the first patient requiring Extracorporeal Membrane Oxygenation for SARS- ...
Oudhuis GJ, Beuving J,et al.Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not ... Diagnostic significance of increased bronchoalveolar lavage fluid eosinophils. Am Rev Respir Dis1990; 142: 642-647. PMID: ... bronchoalveolar lavage fluid.Am Rev Respir Dis. 1991 May;143(5 Pt 1):1121-9. PMID: 2024824. ... ശ്വാസനാളാന്തര സ്രവങ്ങൾ (endotracheal aspirates), ശ്വസനികാവായുകോശ ക്ഷാളനം (Bronchoalveloar Lavage; BAL) വഴി കിട്ടുന്ന ദ്രവം [98] ...
"Exuberant plasmocytosis in bronchoalveolar lavage of the first patient requiring Extracorporeal Membrane Oxygenation for SARS- ...
... via bronchoalveolar lavage), blood, or infected organs. It can also be diagnosed by detection of antigens in blood or urine ...
Microscope detection of eggs or larvae in the coughed up sputum or bronchoalveolar lavage fluid from affected animal ...
Bronchoalveolar lavage. Respiratory therapy/. intubation. *Artificial respiration. *CPR. *Hyperbaric medicine. *Decompression ...
Some historians (for example, Morell Mackenzie) credit Benjamin Guy Babington (1794-1866), who called his device the "glottiscope", with the invention of the laryngoscope.[1] Philipp von Bozzini (1773-1809)[2][3] and Garignard de la Tour were other early physicians to use mouth mirrors to inspect the oropharynx and hypopharynx.[4] In 1854, the vocal pedagogist Manuel García (1805-1906) became the first man to view the functioning glottis and larynx in a living human. García developed a tool that used two mirrors for which the Sun served as an external light source.[5][6] Using this device, he was able to observe the function of his own glottic apparatus and the uppermost portion of his trachea. He presented his findings at the Royal Society of London in 1855.[7][8] All previous observations of the glottis and larynx had been performed under indirect vision (using mirrors) until 23 April 1895, when Alfred Kirstein (1863-1922) of Germany first described direct visualization of the vocal cords. ...
... not 12 other lipoxygenase or cycloxygenase mebolites showed a statistically significantly increase in bronchoalveolar lavage ...
The surgical management of nasal defects and deformities divides the nose into six anatomic subunits: (i) the dorsum, (ii) the sidewalls (paired), (iii) the hemilobules (paired), (iv) the soft triangles (paired), (v) the alae (paired), and (vi) the columella. Surgical correction and reconstruction comprehend the entire anatomic subunit affected by the defect (wound) or deformity, thus, the entire subunit is corrected, especially when the resection (cutting) of the defect encompasses more than 50 percent of the subunit. Aesthetically, the nose-from the nasion (the midpoint of the nasofrontal junction) to the columella-labial junction-ideally occupies one-third of the vertical dimension of the person's face; and, from ala to ala, it ideally should occupy one-fifth of the horizontal dimension of the person's face.[20] The nasofrontal angle, between the frontal bone and the nasion usually is 120 degrees; the nasofrontal angle is more acute in the male face than in the female face. The nasofacial ...
Bronchoscopy[22] with bronchoalveolar lavage (BAL), endobronchial and transbronchial biopsy and epithelial brushing ...
Pneumocystis jirovecii cysts from bronchoalveolar lavage, stained with Toluidine blue O stain. ... can be definitively confirmed by histological identification of the causative organism in sputum or bronchoalveolar lavage ( ...
For PCR testing, the WHO recommends obtaining samples from the lower respiratory tract via bronchoalveolar lavage (BAL), sputum ...
Bronchoalveolar lavage)液可以用作瀰漫性泛細支氣管炎的評估,由患者的灌洗液
The bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis contains a higher concentration of ATP ...
... can be measured in a number of biological fluids including bronchoalveolar lavage fluid (BALF) from asthmatic patients.. ... exacerbations and limit markers of inflammation such as eosinophil counts in the peripheral blood and bronchoalveolar lavage ...
... laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment ...
Diagnostic investigation of ventilator-associated pneumonia using bronchoalveolar lavage: Comparative study with a postmortem ...
On 24 December 2019, Wuhan Central Hospital sent a bronchoalveolar lavage fluid (BAL) sample from an unresolved clinical case ...
Bronchoalveolar lavage (BAL) (also known as bronchoalveolar washing) is a diagnostic method of the lower respiratory system in ... "Therapeutic limited bronchoalveolar lavage with fiberoptic bronchoscopy as a bridging procedure prior to total lung lavage in a ... Bronchoalveolar lavage can be a more sensitive method of detection than nasal swabs in respiratory molecular diagnostics, as ... In particular, bronchoalveolar lavage is commonly used to diagnose infections in people with immune system problems, pneumonia ...
Bronchoalveolar lavage is a test that is sometimes done during a bronchoscopy. It is used to collect a fluid sample for testing ... medlineplus.gov/lab-tests/bronchoscopy-and-bronchoalveolar-lavage-bal/ Bronchoscopy and Bronchoalveolar Lavage (BAL). ... Bronchoalveolar lavage (BAL) is a procedure that is sometimes done during a bronchoscopy. It is also called bronchoalveolar ... What are bronchoscopy and bronchoalveolar lavage (BAL)?. Bronchoscopy is a procedure that allows a health care provider to look ...
Bronchoalveolar Lavage Specimen Collection,ARUP Laboratories is a national reference laboratory and a worldwide leader in ... Cytology, Breast Ductal Lavage. 4. Cytology, Body Cavity Fluid Collection. 5. Cytology, Bronchoalveolar Lavage 1. 6. Cytology, ... Cytology, Bronchoalveolar Lavage 2. 9. Cytology, Fine Needle Aspiration Collection. 10. Cytology, Conjunctival Scraping. 11. ... Cytology, Bronchoalveolar Lavage Specimen Collection. Company. ARUP Laboratories. Item. Cytology, Bronchoalveolar Lavage ...
Detected Predominantly in Bronchoalveolar Lavage Fluid by Use of 16S rRNA Gene Sequencing Analysis Toshinori Kawanami, Kazumasa ... Efficacy of Bilateral Bronchoalveolar Lavage for Diagnosis of Ventilator-Associated Pneumonia Colleen R. Zaccard, Ronald F. ... Usefulness of Two Aspergillus PCR Assays and Aspergillus Galactomannan and β-d-Glucan Testing of Bronchoalveolar Lavage Fluid ... A Comparison of Aspergillus and Mucorales PCR Testing of Different Bronchoalveolar Lavage Fluid Fractions from Patients with ...
Utility of bronchoalveolar lavage in vasculitis patients Joanne Heaton, Noshaba Naz, Sarah Hardy, Janice Harper ... The value of bronchoalveolar lavage in the diagnosis and management of small airway disease Jun Kanazawa, Takefumi Saito, ... Are there differences in the bronchoalveolar lavage (BAL) cytokine profile in children with and without allergic asthma? ... Cytotoxic phenotype of alveolar lymphocytes (AL) in bronchoalveolar lavage fluid (BALF) from non-small cell lung cancer (NSCLC ...
Single Cell Flow Cytometry Profiling of Bronchoalveolar Lavage in Children.. Shanthikumar S1,2,3, Burton M4, Saffery R5,6, ... we describe a flow cytometry-based method for purification and characterisation of cell populations in bronchoalveolar lavage ( ...
Bronchoalveolar lavage (BAL) cells from patients with idiopathic pulmonary fibrosis (IPF) were compared to those from ... Bronchoalveolar lavage (BAL) cells from patients with idiopathic pulmonary fibrosis (IPF) were compared to those from ... Current smokers had a marked increase in the macrophage content of lavage fluid. A marginal relationship was noted between the ...
Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage.. Maestrelli P1, Saetta M, Di Stefano ... To determine the relationship between inflammatory cells in sputum, bronchoalveolar lavage (BAL), and bronchial mucosa, we ...
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study. The safety and scientific validity of this study is the ... For participants who will undergo bronchoscopy/ bronchoalveolar lavage (BAL) procedures: 18 to 75 years of age at the time of ...
... Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1860-6 ... the levels of SP-D in sera and bronchoalveolar lavage (BAL) fluids of patients with lung diseases were determined by ELISA, ...
Bronchoalveolar Lavage Fluid IFN-. Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis. Anders Tøndell,1,2,3 Torolf Moen ... Bronchoalveolar lavage fluid cells, from 30 patients with sarcoidosis, 18 patients with other diffuse parenchymal lung diseases ... In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 ...
We report isolation and identification of Kerstersia gyiorum by MALDI-TOF MS from a bronchoalveolar lavage isolate in a patient ... Mini bronchoalveolar lavage was performed. The direct Gram stain of the specimen showed moderate polymorphonuclear cells and ... Kerstersia gyiorum Isolated from a Bronchoalveolar Lavage in a Patient with a Chronic Tracheostomy. Meredith Deutscher,1 ... Kerstersia gyiorum was identified from the bronchoalveolar lavage isolate. Kerstersia gyiorum has been isolated from human ...
Patients with histopathologically proved sarcoidosis were studied serially by means of bronchoalveolar lavage, initially at the ... The recovery of lymphocytes and granulocytes in lavage fluid was of limited prognostic value for persistent lung disease. In ... were seen in at least one lavage investigation in 15 of the 16 patients with more active and progressive disease, but in only ... The finding in the two subsequent lavages of lymphocytosis (lymphocytes greater than 30% of recovered cells) or neutrophilia ( ...
Ph 3/4 GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study. The safety and scientific validity of this study is ...
Bronchoscopy and bronchoalveolar lavage can be part of the clinical and diagnostic workup of e-cigarette, or vaping, product ... Bronchoscopy and bronchoalveolar lavage can be part of the clinical and diagnostic workup of e-cigarette, or vaping, product ... Bronchoscopy and bronchoalveolar lavage† (BAL) can be part of the clinical and diagnostic workup of EVALI patients. The ... Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung ...
In normal bronchoalveolar lavage fluid, lymphocytes typically account for fewer than 15% of the total cells. Measurements using ... Quantifying Lymphocytes in Bronchoalveolar Lavage Fluid Ware G. Kuschner, MD; James K. Brown, MD ... Quantifying Lymphocytes in Bronchoalveolar Lavage Fluid. Ann Intern Med. ;119:1050-1051. doi: 10.7326/0003-4819-119-10- ... This differential is not sufficient to explain the findings of a mean bronchoalveolar lavage lymphocyte percentage of 34.5% in ...
... ... We sought to determine if cellular and cytokine profiles in bronchoalveolar lavage fluid (BALF) from subjects with NEHI and FB ...
Quantifying Lymphocytes in Bronchoalveolar Lavage Fluid. Ann Intern Med. ;119:1050-1051. doi: 10.7326/0003-4819-119-10- ...
Collagenase and fibronectin in bronchoalveolar lavage fluid in patients with sarcoidosis. Message subject: (Your Name) has ...
We describe a research technique for fiberoptic bronchoscopy and bronchoalveolar lavage using low pressure suction. The ... Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield. doi: 10.3791/4345 Published: March 24, 2014 ... Bronchoalveolar lavage (BAL) removes nonadherent cells and lung lining fluid from the mucosal surface; biopsy is used to sample ... Rose, A. S., Knox, K. S. Bronchoalveolar lavage as a research tool. Sem. Respir. Crit. Care Med. 28, 561-573 (2007). ...
Clinimetric properties of bronchoalveolar lavage inflammatory markers in cystic fibrosis. *Michael Fayon1,5⇑, ... Bronchoalveolar lavage in children with cystic fibrosis: how many lobes should be sampled? Arch Dis Child 2011; 96: 215-217. ... which determines the extent of the lavaged lung areas), lavage aliquot size and number, and lobe(s) lavaged [25]. In order to ... Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis. Eur Respir J 2001; 17: 281-286. ...
T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of ... Finally, when analyzing TCR V gene usage by CD8+ bronchoalveolar lavage fluid and peripheral blood T cells, a normal V alpha ... T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of ... T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of ...
Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients. To assess ... Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients. Cochrane ...
Bronchoalveolar lavage in pneumoconiosis of coal miners. Cytologic aspects. Rev Fr Mal Respir1983;11:455-66. ... Bronchoalveolar lavage in pneumoconiosis of coal miners. Biochemical aspects. Rev Fr Mal Respir1983;11:417-26. ... The effects of chronic bronchitis and chronic air flow obstruction on lung cell populations recovered by bronchoalveolar lavage ... Clinical guidelines and indications for bronchoalveolar lavage (BAL): report of the European Society of Pneumology Task Group ...
Background. The value of bronchoalveolar lavage (BAL) still remains controversial, prompting a need for further improvement. ... Evaluation of Fractional Analysis of Bronchoalveolar Lavage Combined with Cellular Morphological Features Namiko Taniuchi1,2, ... Keywords: Bronchoalveolar lavage procedure, interstitial lung diseases, sarcoidosis, hypersensitivity pneumonia, lymphocyte ... Evaluation of Fractional Analysis of Bronchoalveolar Lavage Combined with Cellular Morphological Features. Int J Med Sci 2009; ...
Macrophage (AM) and Neutrophil (PMNL) Chemiliuminescence (CL) in Bronchoalveolar Lavage (BAL) Fluid C Ward; C Ward ... in Bronchoalveolar Lavage (BAL) Fluid. Clin Sci (Lond) 1 December 1987; 73 (s17): 33P-34P. doi: https://doi.org/10.1042/ ...
Examination of repeated bronchoalveolar lavage samples showed that the mechanisms of clearance of chrysotile fibres do not ... Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers. ... Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers. ... Asbestos body (AB) concentrations in bronchoalveolar lavage samples of 15 brake lining (BL) workers exposed only to chrysotile ...
Broncho-alveolar lavage cellularity in patients submitted to myocardial revascularization with cardiopulmonary bypass. Three ... This study aimed at evaluating post-CPB lung cell activation by investigating broncho-alveolar lavage (BAL) cellularity in ... This study aimed at evaluating post-CPB lung cell activation by investigating broncho-alveolar lavage (BAL) cellularity in ... concentrations in bronchoalveolar lavage fluid correlate with decreased arterial oxygenation after cardiopulmonary bypass. ...
... Thorax 41(4): 266-273. ... IgG and IgA concentrations were three times greater in lavage fluid from granite workers than the samples from non-industrial ... Immunoglobulin concentrations and lymphocyte counts were determined in bronchoalveolar fluid obtained from nine symptomless, ... Lymphocyte counts in lavage fluid from the workers were significantly greater (15.5%) than control counts (5.6%; p less than ...
Identification of Lipid-Associated Serine and Metallo-Elastase Activity in Bronchoalveolar Lavage Samples D Burnett ; D Burnett ... Adenosine induces histamine release from human bronchoalveolar lavage mast cells Clin Sci (Lond) (April,1999) ... CYFRA 21-1, a Cytokeratin Subunit 19 Fragment, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease ... Insulin-like Growth Factor-1 is Partially Responsible for Fibroblast Proliferation Induced by Bronchoalveolar Lavage Fluid from ...
  • We sought to determine if cellular and cytokine profiles in bronchoalveolar lavage fluid (BALF) from subjects with NEHI and FB would differ from pediatric disease controls. (nih.gov)
  • Eosinophil accumulations are found in bronchoalveolar lavage fluid (BALF) from patients with chronic eosinophilic pneumonia (CEP). (unboundmedicine.com)
  • Laboratory data from both patients showed extensive eosinophilia, their chest X-ray findings revealed multiple pulmonary infiltrates, and their bronchoalveolar lavage fluid (BALF) showed an elevated eosinophil count. (ajtmh.org)
  • In this study, we reviewed the performances of the CryAg detection (Premier EIA, Meridian) routinely performed in broncho-alveolar lavage fluid (BALF) during a 7-year period (2007-2013). (deepdyve.com)
  • Indeed, encapsulated yeasts may be missed due to the cellularity of the broncho-alveolar lavage fluid (BALF) or, by the contrary, some cells may be mistaken for yeasts leading to false-positive results. (deepdyve.com)
  • Measurement of cytokines in peripheral blood and bronchoalveolar lavage fluid (BALF) is a useful method to assess human immune responses in a large range of pulmonary diseases. (uzh.ch)
  • To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. (edu.au)
  • Although studies have suggested that T cell subsets and cytokines in the Bronchoalveolar Lavage Fluid (BALF) may reflect the severity of pneumonia, the exact connection remains un-clarified. (alliedacademies.org)
  • Therefore, analysis of bronchoalveolar lavage fluid (BALF) to support stannosis might be of significant value. (pagepressjournals.org)
  • Objective: To investigate the pathogenesis of miRNA in asthma by measuring the microRNAs (miRNAs) levels in the bronchoalveolar lavage fluid (BALF) cells of children with asthma. (researchsquare.com)
  • In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. (hindawi.com)
  • Predictive value of bronchoalveolar lavage cell analysis in sarcoidosis. (bmj.com)
  • The value of bronchoalveolar lavage (BAL) still remains controversial, prompting a need for further improvement. (medsci.org)
  • The Platelia Aspergillus enzyme immunoassay (EIA) is a 1-stage immunoenzymatic sandwich microplate assay that detects galactomannan in bronchoalveolar lavage (BAL) specimens. (mayomedicallaboratories.com)
  • The quality of case-associated BAL specimens was assessed by measuring dipalmitoylphosphatidylcholine (DPPC), the principal phospholipid in naturally-occurring lung surfactant: the presence of acceptable levels of DPPC confirms that the lavage procedure recovered adequate pulmonary epithelial fluid. (cdc.gov)
  • In their recent article, Roberts and colleagues [1] reported cell counts and differentials in specimens obtained by bronchoalveolar lavage before and after radiotherapy in 17 women with breast cancer. (annals.org)
  • The authors did not, however, provide an explanation for the striking elevation in the mean percentage of lymphocytes in bronchoalveolar lavage specimens obtained before irradiation. (annals.org)
  • Analysis of bronchoalveolar lavage specimens from immunocompromised patients with a protocol applicable in the microbiology laboratory. (asm.org)
  • Bronchoscopic procedures for the diagnosis of lung cancer include cytologic examination of specimens from bronchial biopsy, bronchial brushing, and bronchial washing/bronchoalveolar lavage. (aacrjournals.org)
  • As bronchoalveolar lavage (BAL) fluid samples are generally useful specimens in the diagnosis of invasive pulmonary aspergillosis (IPA), this study was designed to evaluate the incidence of fungal elements in at-risk patients by direct microscopy and culture of BAL samples. (sid.ir)
  • During 1992-1994, 75 of 90 (83%) infants with CF diagnosed by neonatal screening had 150 simultaneous bronchoalveolar lavage (BAL) and oropharyngeal specimens collected for quantitative bacterial culture at a mean age of 17 months (range, 1-52). (semanticscholar.org)
  • Presently, the most common means to diagnose Pneumocystis jiroveci infection is by microscopic detection of the organisms in specimens such as bronchoalveolar lavage, open lung biopsy tissue, induced sputum and transtracheal aspirate. (practo.com)
  • A PCR/ligase chain reaction technique was used to determine K-ras codon 12 mutations in a group of 52 bronchoalveolar lavage specimens from patients at risk of a second lung cancer. (elsevier.com)
  • Lipid-laden alveolar macrophages, also known as pulmonary foam cells, are cells found in bronchoalveolar lavage (BAL) specimens that consist of macrophages containing deposits of lipids (fats). (wikipedia.org)
  • This study aimed at evaluating post-CPB lung cell activation by investigating broncho-alveolar lavage (BAL) cellularity in patients submitted to myocardial revascularization (MR) with CPB. (scielo.br)
  • Cryptococcal antigen detection in broncho-alveolar lavage fluid 2018-08-01 00:00:00 Abstract Cryptococcal antigen (CryAg) testing in serum and CSF is a clue diagnostic tool for cryptococcosis. (deepdyve.com)
  • Monitoring the capillary-alveolar leakage in an A.R.D.S. model using broncho-alveolar lavage. (inserm.fr)
  • OBJECTIVES: We developed a modified broncho-alveolar lavage (BAL) technique in order to perform repeated measurements of capillary-alveolar leakage of a macromolecule in oleic acid (OA)-induced lung injury. (inserm.fr)
  • Under field conditions, non-endoscopic broncho-alveolar lavage (nBAL) samples are increasingly collected. (researchsquare.com)
  • abstract = "Two bronchoalveolar lavages, 24 h apart, were performed on 15 foals, ranging in age from 1 to 21 days. (elsevier.com)
  • In this study, the levels of SP-D in sera and bronchoalveolar lavage (BAL) fluids of patients with lung diseases were determined by ELISA, using human recombinant SP-D as a standard. (nih.gov)
  • Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers. (bmj.com)
  • Furthermore, 70% and 45% of bronchoalveolar lavage fluids from central and peripheral tumors, respectively, reported as cytologically negative were classified as positive using this marker. (aacrjournals.org)
  • Our results show that bronchoalveolar lavage fluids from subjects with lung cancer present a significantly higher expression of factor H than those from patients with nonmalignant pulmonary diseases. (aacrjournals.org)
  • Bronchoalveolar lavage fluid cells, from 30 patients with sarcoidosis, 18 patients with other diffuse parenchymal lung diseases, and 15 healthy controls, were investigated with flow cytometry for intracellular expression of FoxP3. (hindawi.com)
  • Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage. (nih.gov)
  • To determine the relationship between inflammatory cells in sputum, bronchoalveolar lavage (BAL), and bronchial mucosa, we counted the number of leukocytes in sputum, BAL, and bronchial biopsies obtained from subjects with asthma and with chronic bronchitis in stable condition or during exacerbations. (nih.gov)
  • Results were validated in independent sets of bronchoalveolar lavage and sputum supernatants. (aacrjournals.org)
  • Detection of Mycobacterium tuberculosis in sputum, pleural and bronchoalveolar lavage fluid using DNA amplification of the MPB 64 protein coding gene and IS6110 insertion element. (nus.edu.sg)
  • Among idiopathic interstitial pneumonia (IIP), nonspecific interstitial pneumonia (NSIP) has an increased number of lymphocytes in bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia (UIP). (unboundmedicine.com)
  • Bronchoscopy and bronchoalveolar lavage † (BAL) can be part of the clinical and diagnostic workup of EVALI patients. (cdc.gov)
  • We describe a research technique for fiberoptic bronchoscopy and bronchoalveolar lavage using low pressure suction. (jove.com)
  • 2 Bronchoscopy and bronchoalveolar lavage (BAL) are not routinely performed in such patients. (bmj.com)
  • Real-Time Polymerase Chain Reaction Assay on Bronchoalveolar Lavage: An Alternative Method for Diagnosing Chronic Pulmonary Schistosomiasis? (ajtmh.org)
  • In the present work, we retrospectively tested an in-house real-time polymerase chain reaction for Schistosoma (currently validated for diagnosis on stool and on urine) in the bronchoalveolar lavage (BAL) of a couple of those patients, and both resulted positive. (ajtmh.org)
  • In particular, bronchoalveolar lavage is commonly used to diagnose infections in people with immune system problems, pneumonia in people on ventilators, and acute respiratory distress syndrome (ARDS). (wikipedia.org)
  • The usefulness of bronchoalveolar lavage (BAL) fluid cellular analysis in non-human immunodeficiency virus (HIV)-infected patients with Pneumocystis jirovecii pneumonia (PCP) has not been adequately evaluated. (asm.org)
  • Acute eosinophilic pneumonia due to toxocariasis with bronchoalveolar lavage findings. (ajtmh.org)
  • Mannarino R V, March M d F P, Cunha A J L A d, Milward G, Gomes J G, Sant'Anna C C. Bronchial and Bronchoalveolar Lavage in Diagnosis of Subacute and Chronic Pneumonia in Brazilian Children. (pediatriconcall.com)
  • To describe the results of bronchoalveolar lavage (BAL) and bronchial lavage (BL) in the etiological diagnosis of chronic pneumonia in children in a pediatric tertiary center in Rio de Janeiro, Brazil. (pediatriconcall.com)
  • en] OBJECTIVE: To assess the predictive value of the endotoxin level in the bronchoalveolar lavage (BAL) and to propose to the clinician a guide in the diagnosis of gram-negative bacterial (GNB) pneumonia. (ac.be)
  • Objectives: In our retrospective study we investigated the optimal timing of bronchoalveolar lavage (BAL) and the comparison of galactomannan antigen (GM) determined on BAL and serum in patients (pts) with pneumonia. (aspergillus.org.uk)
  • Protected specimen brush or bronchoalveolar lavage to diagnose bacterial nosocomial pneumonia in ventilated adults: A meta-analysis. (ugent.be)
  • de Jaeger A, LITALIEN C, LACROIX J, GUERTIN M, INFANTE-RIVARD C. Protected specimen brush or bronchoalveolar lavage to diagnose bacterial nosocomial pneumonia in ventilated adults: A meta-analysis. (ugent.be)
  • Levels of alpha-amylase in bronchoalveolar lavage (BAL) fluid can be used to detect pulmonary aspiration and predict bacterial pneumonia in critically ill, intubated adults, US researchers report. (medwirenews.com)
  • Bronchoalveolar Lavage of Pneumocystis carinii Pneumonia: Cytological and Ultrastructural Features. (jpatholtm.org)
  • Few data are available about the inflammatory cytokine profile of bronchoalveolar lavage (BAL) from young children with frequent wheeze. (uta.fi)
  • 2012). "An official American Thoracic Society clinical practice guideline: The clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease" (PDF). (wikipedia.org)
  • The diagnostic and prognostic utility of bronchoalveolar lavage (BAL) was first evaluated in historical series in the 1980s, and endorsed by expert groups [ 1 , 2 ]. (ersjournals.com)
  • Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis. (nih.gov)
  • Results: There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. (aacrjournals.org)
  • Unexpectedly, levels of factor H in bronchoalveolar samples correlate with levels of albumin, suggesting that the cause of factor H accumulation in bronchial fluid is not its direct secretion from tumor cells but the exudation of plasma proteins to the bronchial lumen. (aacrjournals.org)
  • Bronchoalveolar lavage can be a more sensitive method of detection than nasal swabs in respiratory molecular diagnostics, as has been the case with SARS-CoV-2 where bronchoalveolar lavage samples detect copies of viral RNA after negative nasal swab testing. (wikipedia.org)
  • Asbestos body (AB) concentrations in bronchoalveolar lavage samples of 15 brake lining (BL) workers exposed only to chrysotile have been determined and compared with those from 44 asbestos cement (AC) workers extensively exposed to amphiboles. (bmj.com)
  • Examination of repeated bronchoalveolar lavage samples showed that the mechanisms of clearance of chrysotile fibres do not affect AB concentration for at least 10 months after cessation of exposure. (bmj.com)
  • IgG and IgA concentrations were three times greater in lavage fluid from granite workers than the samples from non-industrial controls (p less than 0.02). (eurekamag.com)
  • Bronchoalveolar lavage samples were subsequently analyzed for protein and phospholipid content. (biomedsearch.com)
  • Boyden's method was used to assess the chemotactic activity of bronchoalveolar lavage (BAL) fluid samples from patients aged 1-6 yrs with recurrent obstructive bronchitis when signs of chronic mucosal inflammation were observed bronchoscopically. (eurekamag.com)
  • Samples were the bronchoalveolar lavage suspected of tuberculosis (TB) reviews for TB disease negative have been reported. (pagepress.org)
  • Conversely, BAL2 samples preferentially the distal bronchoalveolar space with greater cell viability and higher SP-D. Our findings illustrate how the method of BAL collection can influence analyte concentrations and further emphasize the need for a standardized approach in translational research involving BAL samples. (altmetric.com)
  • We determined the CMV viral load by hybrid capture in bronchoalveolar lavage (BAL) fluid samples from patients who had undergone lung transplantation. (elsevier.com)
  • If samples are needed, a bronchial lavage may be performed, meaning that a saline solution is introduced to flush the area prior to collecting cells for laboratory analysis. (encyclopedia.com)
  • In this study we investigated the possible link between the levels of inflammatory cytokines in bronchoalveolar lavage (BAL) in patients with TB or ARDS alone or in patients with TB-induced ARDS (ARDS + TB). (nih.gov)
  • Cytokines levels in bronchoalveolar lavage (BAL) of patients with tuberculosis (TB), acute respiratory distress syndrome (ARDS) and the combination of both TB and ARDS. (nih.gov)
  • We investigated the suitability of isotope-dilution liquid chromatography coupled with tandem mass spectrometry for identifying vitamin E acetate (VEA) in bronchoalveolar lavage (BAL) fluid. (cdc.gov)
  • Reference : Correlation between endotoxin level and bacterial count in bronchoalveolar lavage flu. (ac.be)
  • Fingerprint Dive into the research topics of 'Bronchoalveolar lavage in the newborn foal. (elsevier.com)
  • This article summarises the work of the inflammatory markers group on inflammatory markers obtained via bronchoalveolar lavage (BAL) and is one of a series of documents from the six groups. (ersjournals.com)
  • It is concluded that occupational exposure to granite dust is associated with an increased proportion of lymphocytes and an increased concentration of immunoglobulin in lavage fluid that may reflect a subclinical immune inflammatory response. (eurekamag.com)
  • AbstractObjective To determine the concentration of proteins and phospholipids, markers of inflammatory reaction such as platelet-activating factor (PAF), and cell alterations in bronchoalveolar lavage (BAL) fluid during the evolution of the acute respiratory distress syndrome (ARDS). (semanticscholar.org)
  • Bronchoalveolar lavage (BAL) cells from patients with idiopathic pulmonary fibrosis (IPF) were compared to those from nonsmoking and smoking normal volunteers to identify determinants of BAL cellularity in IPF. (cdc.gov)
  • Bronchoalveolar lavage (BAL) (also known as bronchoalveolar washing) is a diagnostic method of the lower respiratory system in which a bronchoscope is passed through the mouth or nose into an appropriate airway in the lungs, with a measured amount of fluid introduced and then collected for examination. (wikipedia.org)
  • In a research context BAL utilizes a different technique from that practiced by respiratory and intensive care physicians (often termed bronchial wash, washings, lavage, or BAL) who are aiming to gain diagnostic or therapeutic benefit. (jove.com)
  • Most of the centers that perform pediatric bronchoscopy in Brazil use diagnostic bronchoscopy with bronchial lavage (BL) to collect material for microbiological examination because bronchoalveolar lavage (BAL) requires more technical training and expertise in analysis of the material. (pediatriconcall.com)
  • Bronchoalveolar lavage (BAL) has been used in diagnostic and prognostic evaluation in diffuse parenchymal lung disease for three decades and has a central role in the diagnosis of a number of rare disorders and in excluding opportunistic infection in treated patients. (ersjournals.com)
  • Pneumocystis Carinii Stain Pas Bronchoalveolar Lavage in Gurgaon Sector 40, Gurgaon. (practo.com)
  • Are there differences in the bronchoalveolar lavage (BAL) cytokine profile in children with and without allergic asthma? (ersjournals.com)
  • The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar lavage fluid obtained from 12 patients with pulmonary sarcoidosis, six patients with extrinsic allergic alveolitis, nine patients with cryptogenic fibrosing alveolitis, 11 normal non-smokers, and 12 normal smokers. (uni-regensburg.de)
  • In the first lavage, a numerical deficiency in alveolar macrophages was demonstrated in foals up to 2 weeks of age when compared with older (2-3 years of age) horses. (elsevier.com)
  • In the second lavage, although an increase of alveolar macrophages was noted, a dramatic increase of polymorphonuclear neutrophil (PMN) mobilization occurred in the foals, thus providing a phagocytic back-up for the alveolar macrophage host defence mechanism. (elsevier.com)
  • A similar enhancement in SAF RNA expression is also detected in the HIV-1-infected airway macrophages obtained by bronchoalveolar lavage of HIV-1-infected individuals. (pnas.org)
  • Unopposed neutrophil elastase in bronchoalveolar lavage from transplant recipients with cystic fibrosis. (sigmaaldrich.com)
  • The Standardisation Committee of the European Cystic Fibrosis Society Clinical Trial Network has undertaken the evaluation of clinical end-points for therapeutic interventions regarding their use in multicentre clinical trials in cystic fibrosis (CF). This review of biomarkers in bronchoalveolar lavage (BAL) is part of the group's work. (ersjournals.com)
  • Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis. (semanticscholar.org)
  • Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial. (semanticscholar.org)
  • Detection of toxicants in bronchoalveolar-Iavage (BAL) fluid from patients with EVALI can provide direct information on exposure within the lung. (cdc.gov)
  • With the use of sensitive detection techniques, we report a higher prevalence of K-ras mutations in bronchoalveolar lavage than has been reported previously for lung cancer. (elsevier.com)
  • Culture and histopathological examination of bronchoalveolar lavage (BAL) fluid are useful but have suboptimal sensitivity and in the case of culture may require several days for fungal growth to be evident. (biomedcentral.com)
  • This differential is not sufficient to explain the findings of a mean bronchoalveolar lavage lymphocyte percentage of 34.5% in patients before irradiation. (annals.org)
  • Computed tomography (CT) imaging findings in the lungs in the setting of an acute allergic response and following bronchoalveolar lavage (BAL) are not well established. (physiciansweekly.com)
  • The cytological and ultrastructural findings of Pneumocystis carinii(PC) obtained from rats by bronchoalveolar lavage(BAL) are described. (jpatholtm.org)
  • Determinants of bronchoalveolar lavage cellularity in idiopathic pulmonary fibrosis. (cdc.gov)
  • We also performed repeated TCR V gene analyses on some HLA-DR3+ patients and found an association between the ratio bronchoalveolar lavage fluid/peripheral blood V alpha 2.3+ CD4+ T cells and clinical signs of disease activity. (pnas.org)
  • Finally, when analyzing TCR V gene usage by CD8+ bronchoalveolar lavage fluid and peripheral blood T cells, a normal V alpha 2.3 usage was found in all cases, but lung-restricted T-cell expansions using other TCR V gene segment products were identified. (pnas.org)
  • Immunoglobulin concentrations and lymphocyte counts were determined in bronchoalveolar fluid obtained from nine symptomless, healthy, non-smoking granite workers (mean age 45.6, range 22-56 years) and nine normal, non-smoking, non industrial controls (mean age 22.8, range 21-32 years). (eurekamag.com)
  • Bronchoalveolar lavage (BAL) is a pulmonary sampling technique for characterization of drug concentrations in epithelial lining fluid and alveolar cells. (diva-portal.org)
  • The normal albumin concentration suggests that differences in permeability do not account for all of the increased immunoglobulin concentrations found in granite workers' lavage fluid and that some immunoglobulin is locally synthesised. (eurekamag.com)
  • Lower concentrations of uncorrected glutathione in the bronchoalveolar lavage fluid were found on the first day of life in seven infants who subsequently developed chronic lung disease when compared with 27 infants who did not require supplemental oxygen at 36 weeks' postconceptional age. (bmj.com)
  • Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects. (physiciansweekly.com)
  • Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft. (aspergillus.org.uk)
  • We examined transcriptional profiles in 3- or 6-month surveillance bronchoalveolar lavage fluid cell pellets from recipients with Aspergillus fumigatus colonization (n = 12) and without colonization (n = 10). (aspergillus.org.uk)
  • Faculty Opinions recommendation of De novo assembly of the Pneumocystis jirovecii genome from a single bronchoalveolar lavage fluid specimen from a patient. (growkudos.com)
  • The recovery of lymphocytes and granulocytes in lavage fluid was of limited prognostic value for persistent lung disease. (bmj.com)
  • Sarcoidosis and tuberculosis cytokine profiles: indistinguishable in bronchoalveolar lavage but different in blood. (surrey.ac.uk)
  • Retired underground miners were investigated to document alveolitis, and to observe the difference in the cellular profiles of bronchoalveolar lavage (BAL) fluid with or without pneumoconiosis. (bmj.com)
  • Patients with histopathologically proved sarcoidosis were studied serially by means of bronchoalveolar lavage, initially at the time of diagnosis and then six and 12 months later. (bmj.com)
  • Collagenase and fibronectin in bronchoalveolar lavage fluid in patients with sarcoidosis. (bmj.com)
  • Using three different liquid chromatography coupled to tandem mass spectrometry targeted platforms (LC-MS/MS), we quantified a broad suite of lipid mediators including eicosanoids, sphingolipids and endocannabinoids in bronchoalveolar lavage (BAL) fluid from pulmonary sarcoidosis patients ( n = 41) and healthy controls ( n = 16). (springer.com)
  • Bronchoalveolar lavage (BAL) is a procedure that is sometimes done during a bronchoscopy. (medlineplus.gov)
  • This procedure was followed by the zero time sampling bronchoalveolar lavage, which verified the efficacy of the reduction lavage. (biomedsearch.com)
  • A Nocardia-like organism was detected in the direct microscopic evaluation of the patient's bronchoalveolar lavage (Gram-positive and weakly acid-fast with branching filamentous rods) (figure 2). (thefreelibrary.com)
  • The proteins were measured in unconcentrated lavage fluid by means of a solid phase, enzyme linked immunosorbent assay. (eurekamag.com)
  • Database of bronchoalveolar lavage fluid proteins. (ac.be)
  • Current smokers had a marked increase in the macrophage content of lavage fluid. (cdc.gov)
  • Presumably, other chemo-attractants (leukotriens, enzymes) can also be found in the lavage fluid beside macrophage- or serum-derived and locally activated complement components. (eurekamag.com)
  • Mulshine, James L. / High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer . (elsevier.com)
  • In contrast, patients with increased numbers of mast cells recovered by lavage were more likely to deteriorate. (bmj.com)
  • The finding in the two subsequent lavages of lymphocytosis (lymphocytes greater than 30% of recovered cells) or neutrophilia (neutrophils greater than 15%) combined with mastocytosis (mast cells greater than or equal to 0.5%) occurred in nine of the 16 patients with active disease but in no patients with inactive disease. (bmj.com)
  • Single Cell Flow Cytometry Profiling of Bronchoalveolar Lavage in Children. (nih.gov)
  • Methods: Complement factor H, a protein secreted by lung cancer cells, was quantified in a series of bronchoalveolar lavage supernatants from lung cancer patients and patients with non-malignant respiratory diseases. (aacrjournals.org)
  • OBJECTIVES: To examine the effect of tumor necrosis factor-alpha (TNF-alpha) on pulmonary artery pressure and on total protein, phospholipid, lysophosphatidylcholine, phosphatidylcholine, phosphatidylinositol, and phosphatidylglycerol content in the bronchoalveolar lavage-accessible space of the isolated perfused rat lung, and to evaluate the role of the lung in the clearance of TNF-alpha from the perfusion medium in this model. (biomedsearch.com)
  • The lavage method increased total cells and total protein/albumin in uninjured and O3-exposed mice, with the 800-μl instillation having the highest values. (ovid.com)
  • METHODS: IL-9 protein was measured in bronchoalveolar lavage (BAL) fluid by means of ELISA and detected within the BAL cells by means of immunocytochemistry. (fraunhofer.de)