Bronchiolitis Obliterans: Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.Cryptogenic Organizing Pneumonia: An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.Bronchiolitis: Inflammation of the BRONCHIOLES.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Bronchiolitis, Viral: An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.Thromboangiitis Obliterans: A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.Collagen Type V: A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.Flavoring Agents: Substances added to foods and medicine to improve the quality of taste.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Bronchoalveolar Lavage Fluid: Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.Mediastinal Emphysema: Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Respiratory Aspiration: Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Syndrome: A characteristic symptom complex.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Balanitis Xerotica Obliterans: An atrophic and sclerotic condition of the head of the PENIS, glans penis. Sometimes it leads to stenosis and occasionally obliteration of the external meatal orifice.Lung Diseases: Pathological processes involving any part of the LUNG.Diacetyl: Carrier of aroma of butter, vinegar, coffee, and other foods.Respiratory Syncytial Virus Infections: Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Nasal Lavage: Irrigation of the nose with saline or irrigation solutions for diagnostic or therapeutic purposes. It is used to remove irritants, allergens, or microorganisms from the nose.Instillation, Drug: The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Bronchi: The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.Bronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.Leukocyte Disorders: Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells.Bronchial DiseasesRacepinephrine: A racemic mixture of d-epinephrine and l-epinephrine.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Bronchoalveolar Lavage: Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.Pneumonia: Infection of the lung often accompanied by inflammation.Trachea: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.Costimulatory and Inhibitory T-Cell Receptors: A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. Although commonly referred to as costimulatory receptors, some of the receptors have inhibitory effects such as inducing PERIPHERAL TOLERANCE.Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Primary Graft Dysfunction: A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.Respiratory Syncytial Viruses: A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Lung Diseases, Interstitial: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Oxygen Inhalation Therapy: Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Adrenal Cortex HormonesAcute Disease: Disease having a short and relatively severe course.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Respiratory Syncytial Virus, Human: The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. (1/382)

Leukemic patients receiving marrow from HLA-identical sibling donors were randomized to treatment with either busulfan 16 mg/kg (n = 88) or total body irradiation ([TBI] n = 79) in addition to cyclophosphamide 120 mg/kg. The patients were observed for a period of 5 to 9 years. Busulfan-treated patients had an increased risk of veno-occlusive disease (VOD) of the liver (12% v 1%, P =.01) and hemorrhagic cystitis (32% v 10%, P =.003). Acute graft-versus-host disease (GVHD) was similar in the two groups, but the 7-year cumulative incidence of chronic GVHD was 59% in the busulfan-treated group versus 47% in the TBI group (P =.05). Death from GVHD was more common in the busulfan group (22% v 3%, P <.001). Obstructive bronchiolitis occurred in 26% of the busulfan patients but in only 5% of the TBI patients (P <.01). Complete alopecia developed in 8 busulfan patients and partial alopecia in 17, versus five with partial alopecia in the TBI group (P <.001). Cataracts occurred in 5 busulfan-treated patients and 16 TBI patients (P =.02). The incidence of relapse after 7 years was 29% in both groups. Seven-year transplant-related mortality (TRM) in patients with early disease was 21% in the busulfan group and 12% in the TBI group. In patients with more advanced disease, the corresponding figures were 64% and 22%, respectively (P =.004). Leukemia-free survival (LFS) in patients with early disease was 68% in busulfan-treated patients and 66% in TBI patients. However, 7-year LFS in patients with more advanced disease was 17% in the busulfan group versus 49% in the TBI group (P <.01). In patients with chronic myeloid leukemia (CML) in first chronic phase, 7-year LFS was 72% and 83% in the two groups, respectively.  (+info)

Bilateral pneumothoraces with multiple bullae in a patient with asymptomatic bronchiolitis obliterans 10 years after bone marrow transplantation. (2/382)

A 16-year-old boy developed bronchiolitis obliterans (BO) 10 years after BMT for myelodysplastic syndrome. Although the patient complained of almost no dyspnea on exertion, he had mild hypercapnea with a markedly reduced forced expiratory volume of 0.32 l. Chest X-rays showed occasional bilateral minimal pneumothoraces, which is in accordance with the existence of multiple small bullae found on the pleural surface at video-assisted thoracic surgery. Histologic examination of the biopsied lung revealed BO. This case indicates that BO in adolescence following BMT and possible chronic GVHD may be masked because of lung immaturity at BMT, and BO after BMT may be associated with multiple pleural bullae.  (+info)

Constrictive bronchiolitis obliterans and paraneoplastic pemphigus. (3/382)

Constrictive bronchiolitis obliterans is rare, and the pathogenesis of the disease often remains unknown. This study reports on the case of a 38 yr-old female with constrictive bronchiolitis obliterans and paraneoplastic pemphigus associated with malignant lymphoma. The patient developed progressive obstructive lung disease. The chest radiograph showed almost normal lungs. Paraneoplastic pemphigus is a newly described syndrome in which patients have autoantibodies binding to some epithelia, including in the respiratory tract. The disease develops in association with non-Hodgkin's lymphomas or other malignant neoplasms. The case presented here suggests that constrictive bronchiolitis obliterans associated with paraneoplastic pemphigus may be one of the facets of autoimmune responses in this context.  (+info)

Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. (4/382)

We have been investigating two parameters, donor antigen-specific hyporeactivity and peripheral blood allogeneic microchimerism, to determine whether these parameters will predict a chronic rejection-free state and which recipients may be candidates for steroid withdrawal. We have identified donor antigen-specific hyporeactivity for 33% (16/48) of lung and 23% (11/47) of heart recipients. For both organ groups, the hyporeactive subgroup experienced a lower incidence of chronic rejection. The probability of donor antigen-specific hyporeactivity predicting a chronic rejection-free state is 100% for lung and 91% for heart recipients. We have identified peripheral blood allogeneic microchimerism for 77% (20/26) of lung and 36% (9/25) of heart recipients tested at 12-18 months posttransplant. Donor antigen-specific hyporeactivity correlates with a critical level of donor cells in lung recipients; the probability of high peripheral blood allogeneic microchimerism levels predicting a chronic rejection-free state in lung recipients is 100%. The results in heart recipients are not as clear with a short-, but not long-term, trend of higher chimerism levels correlating with the development of donor antigen-specific hyporeactivity. These results illustrate the usefulness of immmune parameters to predict long-term graft outcome in an organ-specific manner.  (+info)

Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplant. (5/382)

The major cause of mortality in the long-term in lung transplant recipients is chronic rejection. This is a fibroproliferative process in the small airways leading to obliterative bronchiolitis and progressive loss of lung function, both constituting the clinical entity bronchiolitis obliterans syndrome (BOS). Granulocyte activation has been implicated as one factor behind BOS. Granulocyte markers in bronchoalveolar lavage (BAL) fluid were prospectively and longitudinally studied in order to identify possible association with BOS. BAL fluid from 266 bronchoscopy procedures performed in twelve single lung, eight bilateral lung and five heart/lung transplant recipients were analysed. The majority (19 of 25) were studied for a period of 2 yrs after surgery. Myeloperoxidase (MPO), eosinophil cationic protein (ECP) and interleukin-8 (IL-8) levels were used as indirect markers of activation and attraction of granulocytes. Five patients developed BOS. Ninety-eight episodes of acute rejection, nine of bacterial infection, 19 of cytomegalovirus pneumonitis, nine of Pneumocystis carinii infection, two of aspergillus infection and two of respiratory syncytial virus infection were diagnosed. BOS patients had significantly higher mean levels of MPO, ECP and IL-8 compared to patients without BOS, irrespective of acute rejection status. Over time, the five patients with BOS had significantly elevated BAL fluid levels of MPO and ECP as well as neutrophil percentages, and in four patients this increase preceded the clinical diagnosis of BOS by several months. Elevated bronchoalveolar lavage fluid neutrophil percentage as well as levels of the granulocyte activation markers myeloperoxidase and eosinophil cationic protein appear to be early signs of development of BOS in lung transplant recipients.  (+info)

Airway neutrophilia in stable and bronchiolitis obliterans syndrome patients following lung transplantation. (6/382)

BACKGROUND: The bronchiolitis obliterans syndrome (BOS) remains the major constraint on the long term success of lung transplantation. Neutrophils have been associated with fibrosing lung conditions and have been noted to be increased in the bronchoalveolar lavage (BAL) fluid of patients with BOS. METHODS: This study was undertaken to examine neutrophil accumulation in the BAL fluid, airway wall and lung parenchyma, as well as levels of interleukin (IL)-8 in the BAL fluid, in normal controls and lung transplant recipients with and without BOS. Bronchoscopic examination included endobronchial biopsy (EBB), BAL fluid, and transbronchial biopsy (TBB) sampling. Tissue neutrophils were identified by neutrophil elastase staining on 3 microm paraffin biopsy sections and quantified by computerised image analyser. IL-8 levels were measured in unconcentrated BAL fluid by ELISA. RESULTS: Compared with controls, airway wall neutrophilia was increased in both stable lung transplant recipients and those with BOS (p<0.05). BAL neutrophils and IL-8 levels were also increased in both groups of transplant recipients compared with controls (p<0.01), the levels being significantly higher in the BOS group (p<0.01). Neutrophil numbers in the lung parenchyma were not significantly different between the two groups of lung transplant recipients. CONCLUSION: Increased levels of neutrophils are present in the airway wall and BAL fluid of lung transplant recipients with and without BOS. BAL fluid levels of IL-8 are also increased, raising the possibility that neutrophils and/or IL-8 may play a part in the pathogenesis of BOS following lung transplantation.  (+info)

Clinical and radiological characteristics of lung disease in inflammatory bowel disease. (7/382)

The pulmonary associations of inflammatory bowel disease (IBD) are poorly characterized. The clinical, physiological and high-resolution computed tomographic thorax characteristics of the lung disease in patients with IBD presenting with respiratory symptoms are described. Detailed clinical information was obtained and standard pulmonary physiological tests and thorax high-resolution computed tomography performed on 14 patients with ulcerative colitis (UC) and three with Crohn's disease (CD), 10 male, aged 38-83 yrs. Respiratory symptoms had been present for 2-50 yrs and extraintestinal manifestations were present in three (17.6%). Normal pulmonary physiology (six patients) was associated with the high resolution computed tomographic changes of bronchiectasis, mosaic perfusion and air trapping suggestive of obliterative bronchiolitis and a pattern of centrilobular nodules and branching linear opacities ("tree in bud" appearance) suggestive of either cellular bronchiolitis or bronchiolectasis with mucoid secretions. Bronchiectasis was found in 13 patients (11 UC, 2 CD), 11 had air trapping and five had a "tree in bud" appearance on computed tomography. One patient had a predominantly peripheral reticular pattern at the lung bases similar to that found in cryptogenic fibrosing alveolitis and one patient had a mixed reticular and ground-glass pattern in the midzones with a patchy distribution in the central and peripheral portions of the lungs with air trapping. Eleven patients (three with alveolitis) exhibited a clinical and/or physiological response to steroids. Pulmonary abnormalities in ulcerative colitis and Crohn's disease can present years after the onset of the bowel disease and can affect any part of the lungs. Early recognition is important as they can be strikingly steroid-responsive.  (+info)

B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia. (8/382)

Interstitial lung diseases are thought to be associated with the infiltration of activated T-lymphocytes. To induce an effective immune response, antigen-presenting cells have to not only present antigenic peptide with major histocompatibility complex (MHC) molecules to T-lymphocytes but also express B7 molecules. Therefore, the expression of B7-1, B7-2 and class II MHC molecules was investigated in lung tissues from patients with idiopathic pulmonary fibrosis (IPF) and bronchiolitis obliterans-organizing pneumonia (BOOP), and in normal lung parenchyma as a control, using immunohistochemical localization. B7-1 and B7-2 were aberrantly expressed in bronchiolar and alveolar epithelial cells, and class II MHC molecules were also aberrantly expressed in bronchiolar epithelial cells in IPF. B7-1 was aberrantly expressed in bronchiolar epithelial cells in BOOP. There was no significant difference in the expression of these proteins in alveolar macrophages between IPF and control subjects. However, B7-2 and class II MHC molecule expression in alveolar macrophages was decreased in BOOP compared with that in control subjects. Expression of CD28 and CTLA4, receptors for B7 molecules, was detected in infiltrating lymphocytes in lung tissues in IPF and BOOP. It was concluded that bronchiolar and alveolar epithelial cells may actively participate in the pathophysiology of idiopathic pulmonary fibrosis through the aberrant expression of B7 and class II major histocompatibility complex molecules. The dysregulation of these molecules in epithelial cells may lead to the activation of autoreactive T-lymphocytes, which might contribute to the pathogenesis of fibrosing lung diseases.  (+info)

Chronic allograft dysfunction in form of bronchiolitis obliterans is the most important hurdle to improved longterm survival after clinical lung transplantation to date. Recently, it was observed that the progression of bronchiolitis obliterans in lung transplant recipients might be inhibited by macrolide antibiotics. The authors therefore tested whether macrolide therapy can attenuate fibrous obliteration of airways in an animal model of bronchiolitis obliterans. Rats with heterotopic tracheal allografts were treated intraperitoneally with clarithromycin and compared to untreated transplanted animals with respect to allograft histology and expression of selected cytokines. At day 21 after transplantation, the tracheal allografts of treated animals were free of fibrous material or partially occluded dependent of clarithromycin dosage. Untreated animals had completely obliterated allografts. In treated animals, tumor necrosis factor alpha (TNF-alpha) was down-regulated early (5 days) and late (21 ...
Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation (ALLOZITHRO ...
PRIMARY OBJECTIVES:. I. To determine if the combination treatment of FAM administered in post hematopoietic cell transplantation (HCT) recipients after the diagnosis of new onset bronchiolitis obliterans syndrome (BOS) can decrease the rate of treatment failure relative to an estimated historical rate of 40% using current therapies.. SECONDARY OBJECTIVES:. I. To confirm the safety profile of FAM.. II. To describe the effect on other standard pulmonary function test parameters: forced expiratory flow at 25%-75% of forced vital capacity (FVC) (FEF25-75), residual volume (RV), diffusion capacity of carbon monoxide (DLCO), forced expiratory volume in 1 second (FEV1)/FVC ratio and FEV1/slow vital capacity (SVC) ratio with FAM treatment.. III. To determine the change in molecular markers of inflammation and fibrosis in the blood with FAM treatment.. IV. To assess the impact of FAM on other chronic graft-versus-host disease (GVHD) manifestations.. V. To assess the impact of FAM on functional status, ...
TY - JOUR. T1 - Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome- mediated endothelin-1 gene transfer. AU - Takeda, Shin Ichi. AU - Sawa, Yoshiki. AU - Minami, Masato. AU - Kaneda, Yasufumi. AU - Fujii, Yoshitaka. AU - Shirakura, Ryota. AU - Yanagisawa, Masashi. AU - Matsuda, Hikaru. PY - 1997/6. Y1 - 1997/6. N2 - Background. Bronchiolitis obliterans (OB) is a lesion that results when injury to small conducting airways is repaired by a proliferation of fibrous granulation tissue. Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung transplantation. Endothelin-1 lET-1), initially discovered as a vasoconstrictive peptide, has a mitogenic activity on vascular smooth cells and airway epithelial cells. Overproduction of endothelin has been reported in patients with OB or chronic rejection after lung transplantation. It is still undetermined whether locally overexpressed ET-1 has a potential impact in the ...
Lung transplant survival is usually limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. CD4, T-cells, lung transplantation, Th17 cells, STAT3, T-cells Introduction Lung transplantation is usually a useful therapeutic option for patients with end-stage lung diseases. The major obstacle limiting lung transplant survival and function is usually chronic lung allograft dysfunction (CLAD), Cichoric Acid IC50 with one of the major manifestations being obliterative bronchiolitis (OB) with fibrous obliteration of the airways (1). Progressive air passage injury mediated by ongoing alloimmune and nonalloimmune responses to the lung allograft is usually thought to be the precursor of subsequent graft CALML3 fibrosis (2). OB/BOS remains one of the major limitations to long term success of lung transplant with approximately 50% of lung transplant recipients affected by 5 years (3). Recently, IL-17 and T helper 17 (Th17) cells have been linked to OB/BOS development ...
MARTINS, Ronaldo Soares; MACHADO, Juliano Antunes e TEIXEIRA, Rosângela. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a. Rev. Soc. Bras. Med. Trop. [online]. 2012, vol.45, n.5, pp.655-656. ISSN 0037-8682. https://doi.org/10.1590/S0037-86822012000500023.. The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, ...
Traffic-related air pollution, as estimated by the proximity of the home to a major road, is a major risk factor for BOS and mortality after lung transplantation. The risk was present in either a dichotomous or a continuous analysis, and was not affected by adjustments for relevant covariables. Indicators of pulmonary (BAL neutrophils, IL-6) and systemic (plasma CRP) inflammation, which are probably involved in the onset of BOS, were also associated with proximity to traffic.. The strengths of our study include the relatively large lung transplant population from a single centre and the statistically robust associations. The statistical significance of our observations follows in part from the high incidence of BOS and mortality. The robustness of the associations is apparent from the fact that inclusion of relevant potential confounders, ranging from SES, transplantation-related characteristics to active smoking, tended to increase the risk estimates.18. Many other authors have estimated ...
Importance: Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post-lung transplant bronchiolitis obliterans syndrome. Objective: To evaluate if the early administration of azithromycin can improve airflow decline-free survival after allogeneic HSCT. Design, Setting, and Participants: The ALLOZITHRO parallel-group trial conducted in 19 French academic transplant centers and involving participants who were at least 16 years old, had undergone allogeneic HSCT for a hematological malignancy, and had available pretransplant pulmonary function test results. Enrollment was from February 2014 to August 2015 with follow-up through April 26, 2017. Interventions: Patients were randomly assigned to receive 3 times a week either 250 mg of azithromycin (n = 243) or placebo (n = 237) for 2 years, starting at the time of the ...
The algorithm used for BOS staging based on home measurements was developed after a retrospective review of home spirometry collected for a minimum of 1 year by
en] A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT) from an HLA-matched brother who suffered from severe Crohns disease. BOOP occurred 20 days after idiopathic interstitial pneumonia, in the context of severe ulcerative colitis. Lung and colon biopsies showed no signs of CMV infection or GVHD. The patient was treated with oral methylprednisolone 1 mg/kg/day and his clinical status and chest X-ray improved slowly. Remarkably, the symptoms of colitis also resolved with prednisone therapy and he is now symptom-free. We hypothesize that ulcerative colitis may have been transmitted from donor to recipient (adoptive autoimmunity) and that it was complicated by BOOP. However, other factors such as CMV may have contributed to the occurrence of BOOP ...
Program Director/Principal Investigator (Last, First, Middle): Welgt, Stephen, Samuel PROJECT SUMIVIARY (See instructions): , This proposal outlines a five year...
Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO ...
Bronchiolitis obliterans organizing pneumonia (BOOP) is defined as "A disease formerly considered a form of interstitial pneumonia. Its etiology is obscure but it may be associated with toxic fumes, infection, and connective tissue disease. Clinical symptoms include cough, dyspnea and influenza-like symptoms with the development of the usual interstitial pneumonia in many cases. Obstructive symptoms are limited to smokers. There are patchy polypoid masses of intra-alveolar granulation tissue in small airway lumina and alveolar ducts. "Organizing" refers to unresolved pneumonia (in which the alveolar exudate persists and eventually undergoes fibrosis) in which fibrous tissue forms in the alveoli."[1] ...
A histologic term referring to two broad groups of lesions: proliferative bronchiolitis obliterans with granulation tissue polyps filling small airways, and fibrotic bronchiolitis obliterans with permanent scarring and stenosis or obliteration of airways. Proliferative bronchiolitis obliterans is often associated with organizing pneumonia in which the same reparative reaction that is present in the bronchiole extends out into more distal parenchyma. Histologic bronchiolitis obliterans may or may not be associated with clinical evidence of airway obstruction ...
... BO, informally known as popcorn lung, is a disease that results in obstruction of the smallest airways of the lungs bronchioles du
Bronchiolitis obliterans is a serious, irreversible lung condition. It can develop after exposure to toxic fumes or after transplant surgery.
Bronchiolitis Obliterans Organizing Pneumonia. History. 68 y female admitted to H6 X smoker 4y 40 pack Unresolving respiratory symptoms since Jan/04  Cough , SOB, Fever. History. SOBE on minimal exertion Cough with minimal sputum Fever low grade & occasional night sweating Slideshow 5710055 by kuniko
Looking for bronchiolitis fibrosa obliterans? Find out information about bronchiolitis fibrosa obliterans. Inflammation of the bronchioles with the formation of an exudate and fibrous tissue that obliterate the lumen Explanation of bronchiolitis fibrosa obliterans
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We included three studies that enrolled a total of 413 adult patients that compared tacrolimus with microemulsion or oral solution cyclosporin. All studies were found to be at high risk of bias. Tacrolimus seemed to be significantly superior to cyclosporin regarding the incidence of bronchiolitis obliterans syndrome (RR 0.46, 95% CI 0.29 to 0.74), lymphocytic bronchitis score (MD -0.60, 95% CI -1.04 to -0.16), treatment withdrawal (RR 0.27, 95% CI 0.16 to 0.46), and arterial hypertension (RR 0.67, 95% CI 0.50 to 0.89). However, the finding for arterial hypertension was not confirmed when analysed using a random-effects model (RR 0.54, 95% CI 0.17 to 1.73). Furthermore, trial sequential analysis found that none of the meta-analyses reached the required information sizes and cumulative Z-curves did not cross trial sequential monitoring boundaries. Diabetes mellitus occurred more frequently among people in the tacrolimus group compared with the cyclosporin group when the fixed-effect model was ...
Obliterative bronchiolitis information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin mRNA-binding protein. The influence of diabetes mellitus on short-term outcomes of patients with bleeding 30 day cialis free trial peptic ulcers. A REVIEW OF THE EFFECTIVENESS AND MEANINGFULNESS OF EDUCATIONAL INTERVENTIONS TO ENABLE CHILDREN, YOUNG PEOPLE AND THEIR FAMILIES TO SELF CARE FOR THEIR GASTROSTOMY TUBES IN THE COMMUNITY. The lesion had no canada cialis solid components except for intralesional septa. As part of a broader mixed methods study, this article reports findings from a national survey of nurses and doctors.. Contribution to the knowledge and casuistics of a peculiar and rare form of anomaly of the deciduous teeth The contribution of newly synthesized cholesterol to best orgasims viagra or cialis biliary cholesterol in healthy humans. Bronchiolitis obliterans syndrome (BOS) is a common late complication in lung transplant recipients (LTR).. Variations in state-level buying cialis from canada ...
Citing reports, the drug device platform of Breath Therapeutics involves a liposomal cyclosporine A for the delivery of inhaled drug with PARI Pharmas eFlow nebulizer technology. L-CsA-i, the lead product candidate, has initiated two global phase 3 clinical trials to treat Bronchiolitis obliterans syndrome (BOS), the post-lung transplantation which is respiratory orphan disease that can be fatal and has no approved therapies.. Breath Therapeutics Board Member and Sofinnova Partners Managing Partner, Graziano Seghezzi, said that Breath Therapeutics is a cutting-edge platform with smart entrepreneurs developing products to treat devastating diseases that have no effective treatment, standing as perfect symbol for the companys investment strategy.. The company had clear vision for transatlantic operation that has strong bases in the U.S. and Europe in order to maximize any commercial opportunity. The company believes it has achieved the said vision and has gathered an excellent management team ...
To the Editors:. In order to distinguish the effects of lung disease from those of normal growth and development, lung function is expressed in comparison with reference data, with forced expiratory volume in 1 s (FEV1) commonly being presented as % predicted. FEV1 % pred has been identified as being of prognostic value in cystic fibrosis (CF), such that an FEV1 of ,30% pred or rapid decline to that level should prompt referral to a transplant centre [1]. Subsequent monitoring of FEV1 % pred after lung transplantation is also important for monitoring graft function and is required to detect any signs of rejection or onset of bronchiolitis obliterans syndrome (BOS), a disease defined as a fall in FEV1 of ,20% from baseline determined by the average of two measurements made ≥3 weeks apart. Continuing to monitor FEV1 % pred after the development of BOS has also been shown to provide important insight into the patients prognosis and therapeutic options [2].. Given that FEV1 % pred plays such a ...
Lung transplantation is hampered by bronchiolitis obliterans syndrome (BOS), although recently azithromycin treatment has a published response rate of about 42% in patients with established BOS. We linked this improvement to a reduction in airway neutrophilia and IL8. In the present study, we further investigated the intracellular mechanisms of azithromycin, looking at the possible involvement of mitogen-activated-protein kinases (MAPK) and oxidative stress. Simultaneously, currently used immunosuppressive agents were investigated. Human primary airway smooth muscle cells were stimulated with IL17 and incubated with increasing concentrations of steroids, immunosuppressive agents (tacrolimus, cyclosporine and rapamycin) or macrolides (erythromycin and azithromycin). We measured supernatant IL8 protein, 8-isoprostane and cell lysate MAPK. IL17-induced IL8 production was decreased by both erythromycin and azithromycin. In nonstimulated condition, IL8 production only increased at the highest dose of ...
The differential diagnosis for centrilobular densities generally falls into the category of peribronchiolar disease, but may include perilymphatic or perivascular disease. Centrilobular densities with a "tree-in-bud" appearance are usually due to endo/peribronchiolar diseases and may be seen with bronchopneumonia (particularly in regions peripheral to frank consolidation), bronchiectasis and cystic fibrosis, bronchogenic spread of tuberculosis, bronchiolitis obliterans and bronchiolitis obliterans organizing pneumonia, respiratory bronchiolitis, and hypersensitivity pneumonia [2].. References. 1. Slone R. Differential diagnosis for the chest. In: R Slone, F Gutierrez, A Fisher (eds): Thoracic imaging: a practical approach, New York, 1999, McGraw-Hill, p 38.. 2.Webb W, Müller N, Naidich D. High-resolution CT of the Lung, 2nd ed., Philadelphia, 1996, Lippincott-Raven Publishers, pp 98-103.. ...
Researchers at the Harvard T.H. Chan School of Public Health published a study in Environmental Health Perspectives. They tested a variety of flavored electronic cigarettes and refill liquids and found that 75 percent of them had a flavoring chemical (Diacetyl) that has been linked to cases of severe respiratory disease.. This chemical diacetyl has become infamous by causing a debilitating respiratory disease known as popcorn lung (bronchiolitis obliterans). Bronchiolitis obliterans is an irreversible loss of pulmonary function that can become so severe that the only treatment option may be a lung transplant.. E-cigarettes are on the rise and the FDA is trying to secure the ability to regulate them along with other tobacco and nicotine products. However, because of the lack of regulation, there are potential detrimental health effects in these products, but not many people know about them.. Concerns regarding e-cigarettes primarily focus on nicotine exposure, second-hand exposure, the potential ...
Toxic popcorn sounds like a misnomer. Low in calories and high in fiber, popcorn is often seen as a healthy alternative to other snack foods. But a <"http://www.yourlawyer.com/practice_areas/toxic_substances">toxic chemical called diacetyl that is used to give microwave popcorn a buttery flavor has been linked to a debilitating lung disease called bronchiolitis obliterans â€" otherwise known as “Popcorn Workers Lung.†Now, one of the largest microwave popcorn makers in the country has decided to discontinue use of diacytle. But despite findings that tie diacytle exposure to the dangerous lung disorder, the Food and Drug Administration (FDA) insists that the chemical is safe for consumers. And most other microwave popcorn makers continue to include diacytle in their product â€" even though they don’t always list the chemical on ingredient labels.. Bronchiolitis obliterans is a form of fixed lung disease that makes it difficult for air to flow out of the lungs. The ...
2,3-Butanedione (BD) is a reactive diketone in artificial butter flavors that is thought to cause bronchiolitis obliterans in workers in microwave popcorn manufacturing. Bronchiolitis obliterans is generally not diagnosed until irreversible damage has occurred; therefore a biomarker of early exposure is needed. The potential systemic uptake of BD from inhalation exposure has not been evaluated. The objective here was to evaluate the systemic exposure of BD and binding to hemoglobin and albumin.
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Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic investigation. Other types of articles such as reviews, editorials, a few special articles of interest to the society and the editorial board, scientific letters, letters to the Editor, and clinical images are also published in the Journal. It is a monthly Journal that publishes a total of 12 issues and a few supplements, which contain articles belonging to the different sections ...
It is probable that the process characteristic of thrombo-angiitis obliterans involves vessels in areas other than the extremities more commonly than is believed. Such involvement may only be recognized by careful clinical and pathologic investigation. We have not had an opportunity to examine cases of thrombo-angiitis obliterans after death. Necropsy was performed in seven cases recorded in the literature. Evidence of disease of the coronary arteries was found in four. A summary of these four cases follows:. Case reported by Buerger.-A man aged twenty-four years with thrombo-angiitis obliterans died suddenly following a Gritti-Stokes amputation of the right thigh. He had ...
Transition to adult care in pediatric solid-organ transplant: development of a practice guideline. Authors: Gold A, Martin K, Breckbill K, Avitzur Y, Kaufman M Air pollution and the development of posttransplant chronic lung allograft dysfunction Authors: Bhinder S, Chen H, Sato M, Copes R, Evans GJ, Chow CW and Singer LG. Organ donation and transplantation in Canada:…
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SMRs were elevated 1.6-fold for dyspnea and 2.7-fold for obstruction. The exposure group working in both coffee flavoring and grinding/packaging of unflavored coffee areas had significantly lower mean ratio of forced expiratory volume in 1 s to forced vital capacity and percent predicted mid-expiratory flow than workers without such exposure ...
Background: Airway inflammation plays a major role in the progression of chronic lung diseases. The features of airway inflammation are not well defined among patients with cases of bronchiolitis obliterans (BO) that began in childhood.. Objectives: To investigate the sputum cell and cytokine profiles of stable cases of BO regarding lung function and the involvement of small airway disease (SAD). Methods: Twenty patients with BO (median age=14.5, range=7-23 years) and 23 healthy controls (median age=16.5 years) were investigated. Lung function parameters and bronchial reversibility testing as well as sputum cell and cytokine profiles (IL-1β, IL-6, IL-8, TNF-α, IL-5, IFN-γ, and NFκB regulation) were analysed using quantitative RT-PCR and cytometric bead assay (CBA) in induced sputum.. Results: Patients with BO had significantly lower lung function values, including FVC, forced expiratory volume (FEV1), the Tiffeneau index (FEV1/VC), and MEF25, but increased functional residual capacity ...
Cryptogenic organising pneumonia (COP) is a rare lung condition and a type of interstitial lung disease. Its sometimes called bronchiolitis obliterans organising pneumonia (BOOP).
A report in the Journal of Infection details two cases of immunocompromised Chinese patients who contracted H9N2 avian flu in 2008 and 2009, one of whom required supplemental oxygen. The first patient, a 3-year-old girl from Shenzhen who had leukemia, had a history of contact with live poultry at a restaurant. She experienced flu-like symptoms and shed virus for 10 days before recovering uneventfully. The second patient, a 47-old-woman from the same city who had post-transplant chronic graft-versus-host disease of the liver and lungs and bronchiolitis obliterans, contracted H9N2 avian flu less than a year later. She experienced fever, tachycardia, and respiratory distress that required 3 liters per minute of supplemental oxygen. She was known to visit live-bird markets but did not recall contact with poultry in the days before she became ill. Her chest x-rays showed extensive bilateral interstitial infiltrates, but she was able to go home with supplemental oxygen 10 days later and recovered from ...
Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, et al.. VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease. Journal of Heart and Lung Transplantation. 2011;30:S118 - S118. ...
Arteritis syphilitica obliterans: a pathological report of several cases of complete occlusion of large arteries - aorta, carotid, and subclavian, in which syphilis was the causative ...
This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 patients underwent bilateral lung transplantation and 1 underwent single lung transplantation. Explanted lung pathology confirmed BO in all patients. The median survival after lung transplantation in this group was 24 months. The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO.. ...
TY - JOUR. T1 - Lung transplantation. T2 - Chronic allograft dysfunction and establishing immune tolerance. AU - Gracon, Adam S.A.. AU - Wilkes, David S.. PY - 2014/8. Y1 - 2014/8. N2 - Despite significant medical advances since the advent of lung transplantation, improvements in long-term survival have been largely unrealized. Chronic lung allograft dysfunction, in particular obliterative bronchiolitis, is the primary limiting factor. The predominant etiology of obliterative bronchiolitis involves the recipients innate and adaptive immune response to the transplanted allograft. Current therapeutic strategies have failed to provide a definitive treatment paradigm to improve long-term outcomes. Inducing immune tolerance is an emerging therapeutic strategy that abrogates allograft rejection, avoids immunosuppression, and improves long-term graft function. The aim of this review is to discuss the key immunologic components of obliterative bronchiolitis, describe the state of establishing immune ...
Extracorporeal photopheresis (ECP) is established therapy for palliation of cutaneous T-cell lymphoma, and also effective in other T-cell mediated diseases such as acute and chronic graft-versus-host disease. Indications for use of ECP in acute and chronic rejection in lung transplantation have not been established. This prospective observational study compared rate of change in lung function […]. ...
Researchers have shown for the first time that lung transplant patients in Europe who live on or near busy roads with high levels of air pollution are more likely to die or to experience chronic organ rejection, than those living in less polluted areas.. Dr David Ruttens, from the University of Leuven (Belgium) told the European Respiratory Societys International Congress today (29 September, 2015) that the risk of dying increased by 10% for patients living in an area where air pollution was above World Health Organization (WHO) recommended maximum levels, compared with patients living in areas with lower levels of pollution. However, this increased risk was not seen in lung transplant patients who were taking a class of antibiotics called macrolides, which include azithromycin and clarithromycin.. WHO estimates that 3.7 million people worldwide die prematurely every year as a result of exposure to small particulate matter measuring between 2.5-10 micrometers in diameter (known as PM10). Ten ...
There is significant variability in lung transplant centers approach to HLA (human leukocyte antigen) antibodies, creating heterogeneity regarding their clinical significance. Some institutions use beads coated with multiple HLA to screen candidate sera and then use single antigen beads (SAB) to determine antibody identity if the pre-screen is positive. Other centers do not pre-screen, using SAB alone, which may detect low-level antibodies of unknown significance. The primary objective of this study was to review the current literature to identify sources of heterogeneity in the identification of pre- and post-lung transplant HLA antibodies, particularly regarding antibody detection methods. A random effects model meta-analysis was used to evaluate the relationship between pre-transplant HLA antibodies and the development of de novo donor specific antibodies (dnDSA) and dnDSA and chronic lung allograft dysfunction (CLAD). Each outcome was stratified by method of antibody detection (pre-screen ...
Objectives: Four diacetyl workers were found to have bronchiolitis obliterans syndrome. Exposures, respiratory symptoms, lung function and exposure-response relationships were investigated.. Methods: 175 workers from a plant producing diacetyl between 1960 and 2003 were investigated. Exposure data were used to model diacetyl exposure. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and respiratory symptoms to an internal reference group.. Results: Workers were potentially exposed to acetoin, diacetyl, acetaldehyde and acetic acid. Historic diacetyl exposure ranged from 1.8 to 351 mg/m3, and from 3 to 396 mg/m3 for specific tasks. Diacetyl workers reported significantly more respiratory symptoms compared to the general population sample (continuous trouble with breathing (prevalence ratio (PR) = 2.6; 95% CI 1.3 to 5.1), daily cough (PR = 1.5; 95% CI 1.1 to 2.1), asthma attack (ever) (PR = 2.0; 95% CI 1.2 to 3.4), doctor diagnosed asthma ...
A 17-year-old Asian man presented with a spontaneous pneumothorax, which was treated initially by needle aspiration. It recurred within a week with complete right-sided pneumothorax requiring water-sealed intercostal drainage. The air leak persisted after one week and the patient developed pyrexia with associated neutrophilia and raised serum inflammatory markers. A chest radiograph showed a hydro-pneumothorax and culture of the pleural fluid grew Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA). He was treated with intravenous Piperacillin-Tazobactam resulting in a full clinic-radiological recovery.. A week later his fever returned and repeat chest radiograph showed right middle and lower lobe consolidation associated with recurrent hydro-pneumothorax. A new intercostal drain was inserted and he was intubated and ventilated due to the rapid onset of severe respiratory distress. Computed tomogram (CT scan) of the chest confirmed bilateral patchy consolidation in ...
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(Fr: bronchiolite oblitérante). Pattern distinct from BOOP or AFOP (See section I). It is suspected when airflow obstruction is noted in the context of normal or hyperlucent lungs on chest radiographs and a mosaic or (less often) a tree-in-bud pattern on HRCT studies. HSCT and lung transplant recipients and victims of exposure to noxious gases including chlorine are prone to the development of this complicaton. PMID 20371529, 20441501, 20477273. See under pathology, as bronchiolitis is as the name implies a designation used in pathology
2016 International Society for Heart and Lung Transplantation. Background The diagnosis of antibody-mediated rejection (AMR) in the lung transplant is still an area under investigation. We performed a blinded multicenter study to determine if any statistically significant histologic findings in transbronchial biopsy specimens from lung transplant patients correlate with the presence of donor-specific antibodies (DSAs). Methods We asked 9 pathologists with experience in lung transplantation to evaluate 161 lung transplant biopsy specimens for various histologic parameters. The findings were correlated with antibody status positive for DSAs, positive for non-DSAs, and no antibodies (NABs) present. The significance of each histologic variable was reviewed. Results We found no statistically significant association with acute cellular rejection, airway inflammation, or bronchiolitis obliterans and the presence or absence of antibodies. However, biopsy specimens with DSAs had a statistically ...
A procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients, according to a study published in the Journal of the American College of Surgeons.
TY - JOUR. T1 - Automatic event detection in lung transplant recipients based on home monitoring of Spirometry and symptoms. AU - Wang, Wayne. AU - Finkelstein, Stanley M.. AU - Hertz, Marshall I.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - The goal of this study was to develop, implement, and test an automated decision system to provide early detection of clinically important bronchopulmonary events in a population of lung transplant recipients following a home monitoring protocol. Subjects and Methods: Spirometry and other clinical data were collected daily at home by lung transplant recipients and transmitted weekly to the study data center. Decision rules were developed using wavelet analysis of declines in spirometry and increases in respiratory symptoms from a learning set of patient home data and validated with an independent patient set. Results: Using forced expiratory volume in 1 s or symptoms, the detection captured the majority of events (sensitivity, 80-90%) at an acceptable level of false ...
CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.: Studies on persistent viral infections demonstrate t
article{25205500-431b-46ab-9210-2bfbb4cda0fd, abstract = {,p,AIMS: The aims of this study were two-fold: to develop the concept analysis by Allvin et al. from lung recipients perspective of their post-transplant recovery process and to identify the recovery trajectories including critical junctions in the post-transplant recovery process after lung transplantation.,/p,,p,BACKGROUND: Lung transplantation is an established treatment for patients with end-stage lung disease. The recovery process after lung transplantation is very demanding. Today, patients are expected to play an active role in their own recovery but require ongoing support during the process.,/p,,p,DESIGN: A deductive, retrospective interview study using directed content analysis and Allvins recovery concept analysis.,/p,,p,METHOD: Fifteen adult lung transplant recipients who were due their 12-month follow-up were consecutively included and interviewed during 2015. Patients who were medically unstable or had difficulties ...
Caucasian and Hispanic children who undergo lung transplantation appear to be at greater risk for developing chronic kidney disease, or CKD, according to a small retrospective study conducted at Texas Childrens Hospital.
Mac-Leod syndrome (syn.: Swywer-James-syndrome) is a manifestation of postinfectious obliterative bronchiolitis. The involved lung or portion of the lung does not grow normally and is slightly smaller than the opposite lung (2). Radiographically, pulmonary hyperlucency caused by overdistended alveoli combined with diminished arterial flow characterizes its imaging appearance. The lung is expected to grow by progressive alveolarization in a child between the age of 2 and 8 years. Thereafter, lung growth is related to hyperexpansion of the existing alveoli. Mac-Leod syndrome is characterized by diminished vascularity, arrest of progressive growth and alveolarization of the lung and resultant hypoplasia . Multifocal areas of air trapping may be seen. Patients with Mac-Leod syndrome have a small lung, compensatory overexpansion of the contralateral lung, peripheral bronchi and bronchioles "pruned" secondary to obliterative bronchiolitis, a mosaic pattern of hyperlucency on CT, and small vessels and ...
Over a decade ago major popcorn manufacturers removed diacetyl from their products because of deaths and hundreds of cases of bronchiolitis obliterans, a serious and irreversible lung disease. But some people are still being exposed to diacetyl - not through food flavorings as a worksite hazard, but through e-cigarette vapor.
If you had Popcorn Lung (bronchiolitis obliterans) lung disease from vaping, contact our lawyers for lawsuit info at (866) 920-0753.
In addition to activation of plasminogen, uPA stimulates proliferation of epithelial cells (26, 48, 89). uPA induces proliferation in several cell lines including lung epithelial cells, and the process appears to be uPAR-dependent (43, 50, 76-79, 82). In addition, the uPA-uPAR system exhibits cooperativity with selected integrins to induce phenotypic changes in epithelial cells exposed to hypoxia that are similar to epithelial-mesenchymal transition. Newly recognized pathways by which the lung epithelium can regulate the uPA-uPAR-PAI-1 fibrinolytic system include regulation through uPA signaling, uPA-induced mediator expression, and cross talk between uPA and p53 by which uPA can regulate epithelial cell viability.. A wide range of lung diseases including ARDS, interstitial lung diseases, bronchiolitis obliterans, and drug-induced lung diseases are characterized by lung epithelial cell apoptosis. The interstitial lung diseases are characterized by the development of progressive fibrosis, and ...
Answer 1. What type of tissue fills the RB (respiratory bronchiole) and extends upward and toward the left between the arrows? Granulation tissue. What is the diagnosis of this process? Bronchiolitis obliterans organizing pneumonia-like/cryptogenic organizing pneumonia-like pattern (granulation tissue in airway and adjacent alveoli) Answer 2. What cells are causing the thickening, and what cells predominate in the alveolar spaces? The alveolar wall thickening is caused by myofibroblasts, interstitial lymphoid cells, and type II cells. Macrophages predominate in the alveolar spaces. What is the homogeneous pink material in the alveoli? Protein-rich edema fluid that has sufficient protein to stain with the eosin stain.. ...
BACKGROUND: Cases of H1N1 and other pulmonary infections evolve to acute respiratory failure and death when co\infections or lung injury predominate over the immune response, thus requiring early diagnosis to improve treatment. of airways obliteration and dysfunction on innate immunity, suggesting that treatment should be focused on epithelial repair. was isolated from a blood culture (patients 2 and 3) and spp were identified in tracheal aspirate specimens (patient 1). Patients 1, 2 and 4 are alive, but patients 3 and 5 died of respiratory failure, with concurrent congestive heart failure, hepatic encephalopathy, and acute renal failure. Table 1 Clinical features of the patients. Necrotizing Bronchiolitis, Collapsogenic Diffuse Alveolar Damage and Alveolar Hemorrhage Figure 1 depicts the pathological findings in the surgical lung biopsy specimens. The main pathological features were necrotizing bronchiolitis, clastogenic diffuse alveolar damage (DAD), and alveolar hemorrhage (Table 2). ...
In this study we have adopted a multifunctional approach to identification of EMT ex vivo using cell morphology, upregulation of mesenchymal proteins, downregulation of epithelial proteins, secretion of ECM and a functional assessment of invasive and migratory capacity. This multifunctional approach is likely to be much more robust than reliance on any single marker of EMT. In addition, our quantitative immunohistochemistry has demonstrated reduced epithelial E-cadherin expression and increases in vimentin and α-SMA expression in the airway epithelium of patients with BOS compared with stable recipients and control lung samples.. The results of this study add significantly to the understanding gained from our previously reported pilot observations in the lung transplant airway.10 The present study provides a comprehensive assessment of the ability of airway epithelial cells from the transplanted lung to undergo EMT. Our observations offer significant insight into what might be an important ...
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Swyer-James syndrome (SJS) is a manifestation of postinfectious obliterative bronchiolitis. In SJS, the involved lung or portion of the lung does not grow normally and is slightly smaller than the opposite lung.
most people with severe, end-stage lung disease can be considered for a lung transplant. the procedure should be considered when someone will likely die without the surgery and no other options are av
Pediatric stem-cell-based, tissue-engineered tracheal transplant seems to be feasible, with positive outcome at two years of follow-up.
Lung Transplants are the most difficult of all types of organ transplants because they have the lowest survival rate. Patients need a lung transplant when their lungs have been severely affected by a lung disease to a point that they cannot be healed. Generally, it is assumed that patients requiring lung transplants are smokers. Although…
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Information about lung transplantation, its indications, types of lung transplantation and hospitals offering this transplantation in India.
Spiro PD 2.0 WMS is the first personal spirometer that lets asthma, COPD, cystic fibrosis, and lung transplant patients monitor their lung health.
University of Maryland School of Medicine researchers found that lung transplant recipients who had early signs of organ rejection could increase their chances of survival by inhaling a liposomal form of the immunosuppression drug cyclosporine through an investigational nebulizer. This is the first randomized, controlled study to demonstrate increased survival and improved lung function with this drug-device combination.
Lung Transplant News. Find breaking news, commentary, and archival information about Lung Transplant From The tribunedigital-orlandosentinel
This is the first study to determine diabetes as a risk factor for mortality after lung transplantation. It was revealed diabetics have a 5.6 fold increased risk of death after lung transplant.
Nancy was born with cystic fibrosis (CF), an inherited chronic disease that affects the lungs and pancreas. Read about her lung transplant at UPMC.
Care guide for Lung Transplant (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Care guide for Lung Transplant (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Learn more about Lung Transplant at Grand Strand Medical Center DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
Suffering from scleroderma, Dennis needed a lung transplant. He received one at UPMC and now lives an active life. Read about his experience.
Get the latest updates for Tom Parks Lung Transplant Fund on Help Hope Live. Your tax-deductible donation can make a difference today.
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Sigma-Aldrich offers abstracts and full-text articles by [Adalet Demir, Willy Coosemans, Herbert Decaluwé, Paul De Leyn, Philippe Nafteux, Hans Van Veer, Geert M Verleden, Dirk Van Raemdonck].
NEW YORK (AP) - By the time 10-year-old Sarah Murnaghan finally got a lung transplant last week, shed been waiting for months, and her parents had sued to give her a better shot at surgery.
TY - JOUR. T1 - Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome. AU - Date, Hiroshi. AU - Sano, Yoshifumi. AU - Aoe, Motoi. AU - Goto, Keiji. AU - Tedoriya, Takeo. AU - Sano, Shunji. AU - Andou, Akio. AU - Shimizu, Nobuyoshi. PY - 2002/1/1. Y1 - 2002/1/1. UR - http://www.scopus.com/inward/record.url?scp=0036164451&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0036164451&partnerID=8YFLogxK. U2 - 10.1067/mtc.2002.119331. DO - 10.1067/mtc.2002.119331. M3 - Article. C2 - 11828317. AN - SCOPUS:0036164451. VL - 123. SP - 389. EP - 391. JO - Journal of Thoracic and Cardiovascular Surgery. JF - Journal of Thoracic and Cardiovascular Surgery. SN - 0022-5223. IS - 2. ER - ...
Chronic rejection significantly limits long-term success of solid organ transplantation. De novo donor-specific antibodies (DSAs) to mismatched donor human leukocyte antigen after human lung transplantation predispose lung grafts to chronic rejection. We sought to delineate mediators and mechanisms of DSA pathogenesis and to define early inflammatory events that trigger chronic rejection in lung transplant recipients and obliterative airway disease, a correlate of human chronic rejection, in mouse. Induction of transcription factor zinc finger and BTB domain containing protein 7a (Zbtb7a) was an early response critical in the DSA-induced chronic rejection. A cohort of human lung transplant recipients who developed DSA and chronic rejection demonstrated greater Zbtb7a expression long before clinical diagnosis of chronic rejection compared to nonrejecting lung transplant recipients with stable pulmonary function. Expression of DSA-induced Zbtb7a was restricted to alveolar macrophages (AMs), and ...
Synonyms for Balanitis xerotica obliterans in Free Thesaurus. Antonyms for Balanitis xerotica obliterans. 3 words related to balanitis: inflammation, redness, rubor. What are synonyms for Balanitis xerotica obliterans?
Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and chronic rejection induce exosomes containing HLA and self-antigens (SAg), Kα1Tubulin (Kα1T) and Collagen V (Col-V). We determined whether RVI can induce exosomes containing SAg leading to immune response resulting in rejection and their immunogenicity in mice. Sera from RVI (n=35) and stable LTxR (n=32) were used for exosomes isolation and Abs to SAg. Exosomes were isolated by ultracentrifugation, validated by sucrose cushion and tested for CD-9. SAg, viral antigens for respiratory syncytial virus (RSV), corona virus (CV) and rhino virus (RV) were detected by immunoblot. Exosomes from RVI and stable LTxR were injected subcutaneously (10[micro]g/100[micro]l) into C57BL/6 mice. Sera were analyzed for Abs to SAg by ELISA. Since studies have shown that a primary insult to lung is needed for Abs to SAg to induce ...
Lung transplantation has become a therapeutic option for a number of end-stage pulmonary disorders. Lung transplant recipients experience more complications due to acute and chronic allograft rejection as compared to recipients of other solid organs. We postulated that the generation of TNF-alpha plays a significant role in the pathogenesis of acute lung allograft rejection. To test our hypothesis, we used a RT1-incompatible rat lung allograft model and demonstrated the time course, cellular source(s), and major compartment(s) of TNF production during the course of lung allograft rejection. This model allowed for immunogenetic standardization and reproducibility of lung allograft rejection across disparate major histocompatibility barriers. TNF production was characterized at the whole animal, organ, cellular, and molecular levels, and was found to be compartmentalized and expressed in a bimodal fashion from the lung allograft during lung allograft reimplantation and maximal rejection. Lung ...
BACKGROUND: In an era of increasing ex vivo lung perfusion (EVLP) use, it remains important to describe what outcomes can be achieved without EVLP, by taking an aggressive approach to donor use to maximize lung transplantation. METHODS: Data for all lung transplant donor referrals to the Alfred Hospital in Melbourne, Australia were collected for 2012 to 2013. Donor variables were analyzed and calculated into a previously validated lung donor score. Lung transplant recipient outcome data included the following: primary graft dysfunction; duration of mechanical ventilation; need for cardiopulmonary bypass extracorporeal membrane oxygenation; intensive care and hospital length of stay; 30-day, 1-year, and 3- to 4-year survival rates; rates of acute rejection and chronic lung allograft dysfunction; and peak and 12-month lung function (forced expiratory volume in 1 second ...
Ischemia-reperfusion injury, a form of sterile inflammation, is the leading risk factor for both short-term mortality following pulmonary transplantation and chronic lung allograft dysfunction. While it is well recognized that neutrophils are critical mediators of acute lung injury, processes that guide their entry into pulmonary tissue are not well understood. Here, we found that CCR2+ classical monocytes are necessary and sufficient for mediating extravasation of neutrophils into pulmonary tissue during ischemia-reperfusion injury following hilar clamping or lung transplantation. The classical monocytes were mobilized from the host spleen, and splenectomy attenuated the recruitment of classical monocytes as well as the entry of neutrophils into injured lung tissue, which was associated with improved graft function. Neutrophil extravasation was mediated by MyD88-dependent IL-1β production by graft-infiltrating classical monocytes, which downregulated the expression of the tight ...
Definisi Buerger disease memiliki nama ilmiah, yaitu Thromboangitis Obliterans. Thrombo artinya clot, angitis artinya inflamasi pada pembuluh darah, Obliterans artinya sumbatan. Buerger disease adalah suatu kondisi inflamasi non aterosklesosis yang mengenai arteri dan vena kecil hingga sedang pada ekstremitas atas ataupun bawah. Hal tersebut disebabkan karena adanya obstruksi pada vena atau arteri yang disebabkan oleh…
Figure S1: Low donor lung SP-A mRNA-level associates with decreased survival. The graph shows the survival curves for recipients of double lung transplant excluding patient with ILD. This ad hoc analysis was to address the possible selection bias that is shown in Table S1 with greater percentage of ILD and single lung transplant in the study cohort. Lung transplant patients that received lung allografts with low levels of SP-A mRNA expression prior to implantation had significantly reduced survival. The number of patients in each group is indicated in brackets. The x-axis represents the cumulative survival. Circles indicate the censored patients within the analysis. ...
If like me, I never even knew that Bronchiolitis could kill a child?" she wrote.. "You here[sic] about meningitis, measles, mumps and rubella all being serious childhood illnesses but no body tells you about Bronchiolitis and after speaking with other parents and doctors it is more common than I ever realised especially at this time of year.". Bronchiolitis is an infection of the lungs that causes an inflammation in the bronchioles, the smallest airways that carry oxygen to the lungs.. The ailment is often the result of a virus, and usually develops during the winter months. Symptoms can include:. -Runny nose. -Stuffy nose. -Cough. -Slight fever (but not always). -Wheezing. -Difficulty breathing. -An ear infection in some infants. There is no cure for bronchiolitis, but it usually goes away of its own accord within a few weeks, according to the Mayo Clinic.. Its not clear why sepsis occurs, but it happens when the immune system stops fighting an infection and starts attacking the body instead. ...
Bronchiolitis is a common cause of pediatric hospitalization. Variation in the use of tests and treatments for management of bronchiolitis exists, some of which may contribute to increased health care costs that are estimated to be $545 million annual total direct expenditure nationally.1 In 2006, the American Academy of Pediatrics published a national clinical practice guideline (CPG) for management of children with bronchiolitis.2 The CPG does not recommend routine tests and treatments, emphasizing a diagnosis of bronchiolitis based on history and physical examination, and supportive management. Nevertheless, nationally, there is a wide variation in use of tests and treatments in the management of bronchiolitis.2-4. CPGs can be a powerful resource to reduce variation and help providers deliver disease-specific best practice.5,6 Therefore, many national organizations support development of CPGs.7-9 Integrating a CPG into practice requires changes in physician behaviors and remains a significant ...
Researchers at Mayo Clinic have identified a possible cause for a rare infection in heart and lung transplant recipients: the donor. The way in which heart and lung transplant recipients acquired a specific species of bacteria, Mycoplasma hominis, had been previously undefined, and the bacterium was difficult to test. Originally, this bacterium was considered to reside exclusively in, and be a potential pathogen of, the area of the reproductive and urinary organs - the genitourinary tract.
The following was adapted from the Canadian Pediatric Societys statement on "Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age." Please see the full statement for the full recommendations from the Canadian Pediatric Society.. Background:. Bronchiolitis is a viral lower respiratory tract infection that leads to obstruction of the small airways. Respiratory syncytial virus (RSV) is responsible for most cases, however other viruses can cause a similar clinical picture. In Canada, RSV season usually begins between November and January and persists for four to five months. Bronchiolitis affects more than one third of children in the first two years of life and is the most common cause of admission to hospital in the first year. Despite being so common, there is great variation in standards for diagnosis and management of bronchiolitis, which you may see in clinical practice. These guidelines incorporate the most recent evidence to provide ...
Background: Bronchiolitis is a serious, potentially life-threatening respiratory illness commonly affecting babies. It is often caused by respiratory syncytial virus (RSV). Antibiotics are not recommended for bronchiolitis unless there is concern about complications such as secondary bacterial pneumonia or respiratory failure. Nevertheless, they are used at rates of 34% to 99% in uncomplicated cases. Objectives: To evaluate the effectiveness of antibiotics for bronchiolitis. Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL 2010, issue 4), which includes the Cochrane Acute Respiratory Infection Groups Specialised Register, and the Database of Abstracts of Reviews of Effects, MEDLINE (January 1966 to November 2010), EMBASE (1990 to December 2010) and Current Contents (2001 to December 2010). Selection criteria: Randomised controlled trials (RCTs) comparing antibiotics to placebo in children under two years diagnosed with bronchiolitis, using clinical criteria
While it may occur as a manifestation of transplant rejection or as the result of exposure to toxic gases, bronchiolitis obliterans has been nicknamed "popcorn lung" or "popcorn workers lung" due to onset of this disease from inhalation of airborne diacetyl - a butter flavoring used in popcorn and in many other food flavorings such as those used in candy and even potato chips. Similar fixed obstructive lung disease has also occurred in workers at other plants that use or manufacture flavorings [NIOSH 1986; Lockey et al. 2002]. In animal tests, inhaling vapors from a heated butter flavoring used in microwave popcorn production caused severe injury to airways [Hubbs et al. 2002a].The disease is initiated by damage to the epithelium of the small conducting airways and progresses to inflammation of the airways, frequently to the adjacent alveolar tissue as well. ...
More lawsuits are being prepared for trial on behalf of people sickened with <"http://www.yourlawyer.com/topics/overview/popcorn_workers_lung">Popcorn Lung, a disorder linked to a chemical involved in the manufacture of microwave popcorn and other butter-flavored foods. The Joplin Globe just reported that the second round of lawsuits has been reduced to 11 plaintiffs, with trial dates expected next year.. Originally, said the Joplin Globe, 44 plaintiffs were part of the original lawsuits filed in 2006 in the Jasper County Circuit Court against manufacturers of the butter flavorings at the Jasper Popcorn Co. plant (operating as Gilster Mary Lee Corp. since 1999). The butter flavorings contain a chemical called diacetyl, which has been linked to the very dangerous, and sometimes fatal, lung disease commonly referred to as Popcorn Lung and clinically known as bronchiolitis obliterans.. Original defendants included the flavoring makers International Flavors and Fragrances Inc. (IFF), Bush Boake ...
Bronchiolitis obliterans after aspiration of activated charcoal". Chest. 96 (3): 672-4. doi:10.1378/chest.96.3.672. PMID ...
... some patients develop bronchiolitis obliterans progressing to ARDS. Bronchiolitis obliterans with organized pneumonia can ensue ... and only intensely exposed victims showed signs like bronchiolitis obliterans in the distal part. Secondary effects of sulfur ... Irritant gas exposures predominantly affect the airways, causing tracheitis, bronchitis, and bronchiolitis. Other inhaled ... are more likely to cause severe bronchiolitis, and often have a lag of ≥ 12 h before symptoms of pulmonary edema develop. Acute ...
阻塞性細支氣管炎伴機化性肺炎(英语:Bronchiolitis obliterans organizing pneumonia) ... 細支氣管炎(英语:Bronchiolitis) 阻塞性細支氣管炎. 瀰漫性
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
阻塞性細支氣管炎伴機化性肺炎(英語:Bronchiolitis obliterans organizing pneumonia) ... 細支氣管炎(英語:Bronchiolitis) 阻塞性細支氣管炎. 瀰漫性
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ... bronchiolitis, bronchiectasis, and COPD.[4][2] A chest X-ray may be useful to detect pneumonia.[4] ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
en:Bronchiolitis obliterans (12). *en:Bulimia nervosa (29). *en:Cachexia (35). *en:Candidiasis (47) → 칸디다증 ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
... bronchiolitis obliterans organising pneumonia, BOOP), ARDS (acute respiratory distress syndrome), solitary pulmonary mass (even ...
Airflow obstruction not ascribable to other cause is labeled bronchiolitis obliterans syndrome (BOS), confirmed by a persistent ... after onset of bronchiolitis obliterans syndrome in lung transplant recipients". American Journal of Respiratory and Critical ... In histopathology the condition is bronchiolitis obliterans, which clinically presents as progressive airflow obstruction, ... "Immune mechanisms in the pathogenesis of bronchiolitis obliterans syndrome after lung transplantation". Pediatric ...
... due to cases of the potentially fatal disease bronchiolitis obliterans or "Popcorn Workers's Lung" appearing among plant ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
bronchiolitis obliterans with organizing pneumonia (BOOP). *pulmonary fibrosis. *fatal asymmetric interstitial lung disease[13] ...
It manifests as dyspnea and progresses to bronchiolitis obliterans (non-reversible obstructive lung disease) via an unknown ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
ബ്രോങ്കിയൊളൈറ്റിസ് ഒബ്ലിറ്ററൻസ് സാന്ദ്രീകരണ ന്യുമോണിയ (Bronchiolitis obliterans organizing pneumonia; BOOP)[തിരുത്തുക]. ... Bronchiolitis obliterans organizing pneumonia. Arch Intern Med. 2001 Jan 22;161(2):158-64. PMID: 11176728 ... 2.3.6 ബ്രോങ്കിയൊളൈറ്റിസ് ഒബ്ലിറ്ററൻസ് സാന്ദ്രീകരണ ന്യുമോണിയ (Bronchiolitis obliterans organizing pneumonia; BOOP) ... ശ്വസനികാവീക്കമായിട്ടാണു (bronchiolitis) ബ്രോങ്കോന്യുമോണിയ ആരംഭിക്കുന്നത്. പഴുപ്പും നിസ്രാവവും (exudate) മൂലം ശ്വസനികയും അതിന്റെ ...
Bronchiolitis obliterans with obstructive pulmonary disease. *Bronchiolotis obliterans organizing pneumonia (BOOP). *Bronchitis ...
... "flavorings-related bronchiolitis obliterans"[14] or diacetyl-induced bronchiolitis obliterans.[15] People who work with ... However, lung transplant rejection is very common and happens to be another setting in which bronchiolitis obliterans is known ... Workers in several factories that manufacture artificial butter flavoring have been diagnosed with bronchiolitis obliterans, a ... "Obliterative Bronchiolitis in Workers in a Coffee-Processing Facility - Texas, 2008-2012". Morbidity and Mortality Weekly ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
... in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans" at ...
Bronchiolitis obliterans organizing pneumonia (BOOP). BOOP is caused by inflammation (swelling or irritation) of the small ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. restrictive. (fibrosis). External agents/. ...
Bronchiolitis. Bronchiolitis Obliterans. Bronchitis. Bronchial Diseases. Respiratory Tract Diseases. Lung Diseases, Obstructive ... Bronchiolitis Obliterans Drug: fluticasone propionate Drug: montelukast sodium Drug: azithromycin Phase 2 ... Targeted Therapy of Bronchiolitis Obliterans Syndrome (FAM for BOS). This study has been completed. ... Fluticasone Propionate, Azithromycin, and Montelukast Sodium in Treating Patients With Bronchiolitis Obliterans Who Previously ...
Recently, it was observed that the progression of bronchiolitis obliterans in lung transplant recipients might be inhibited by ... Recently, it was observed that the progression of bronchiolitis obliterans in lung transplant recipients might be inhibited by ... Chronic allograft dysfunction in form of bronchiolitis obliterans is the most important hurdle to improved longterm survival ... Chronic allograft dysfunction in form of bronchiolitis obliterans is the most important hurdle to improved longterm survival ...
Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome. Journal of Thoracic and ... Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome. In: Journal of Thoracic ... Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome. / Date, Hiroshi; Sano, ... title = "Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome", ...
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center ... acute rejection Adherence Antibody-mediated rejection biopsy bronchiolitis obliterans syndrome cancer complement ... associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung ...
Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung ... Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung ... Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung ... Bronchiolitis obliterans has emerged as a main cause of morbidity and mortality in the setting of lung and heart-lung ...
... as bronchiolitis obliterans is a common complication of chronic rejection. Evaluation of interventions to prevent bronchiolitis ... including bronchiolitis obliterans. Industrial workers who have presented with bronchiolitis: nylon-flock workers workers who ... Bronchiolitis obliterans is rare in the general population. It affects about 75% of people by ten years following a lung ... Bronchiolitis obliterans (BO), informally known as popcorn lung, is a disease that results in obstruction of the smallest ...
Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the ... Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the ... Non-Bronchiolitis Obliterans Syndrome Forms of Chronic Lung Allograft Dysfunction Gregory I. Snell, Bronwyn J. Levvey, Glen P. ... Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important ...
CB obliterans is an irreversible condition. This review looks at the current literature an treatment options. ... Classification of Bronchiolitis Obliterans Syndrome Stage. Classification details. BOS 0. 1 , 90% of baseline and FEF25 75 , 75 ... As bronchiolitis obliterans syndrome (BOS) is a clinical diagnosis and probably has a mix of the fibrotic and inflammatory ... BOS: Bronchiolitis obliterans syndrome; BOS 0-p: Potential BOS stage ;0; FEF2575:Forced mid-expiratory flow; FEV1: Forced ...
... is a result of unilateral post infectious bronchiolitis obliterans in infancy and early childhood. Bronchiolitis obliterans is ... Bronchiolitis is inflammation of the bronchioles in the lungs. The consequences of bronchiolitis obliterans include dyspnea ( ... Post infectious bronchiolitis obliterans is a late response to mycoplasma or viral lung infection in adults and has highly ... Bronchiolitis obliterans is a disease in which the bronchioles, and, occasionally some of the smaller bronchi, are partly or ...
... Curr Opin Allergy Clin Immunol. 2007 Apr;7(2):162-7. doi: 10.1097/ACI. ... Purpose of review: In 2000, inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans ... Biologic plausibility of the role of diacetyl and other components of butter flavoring in causing bronchiolitis obliterans ...
Bronchiolitis obliterans organizing pneumonia and Sjögrens syndrome.. Matteson EL1, Ike RW. ... Investigation revealed bronchiolitis obliterans organizing pneumonia associated with retinal vasculitis, hepatic and renal ... Bronchiolitis Obliterans Organizing Pneumonia - Genetic Alliance. *Bronchiolitis Obliterans - Genetic Alliance. *Pneumonia - ...
Bronchiolitis obliterans organizing pneumonia with migratory infiltrates: a late complication of radiation therapy. [AJR Am J ... Bronchiolitis obliterans organizing pneumonia with migratory pulmonary infiltrates.. Epstein DM1, Bennett MR. ... Bronchiolitis Obliterans Organizing Pneumonia - Genetic Alliance. *Bronchiolitis Obliterans - Genetic Alliance. *Pneumonia - ...
Microparticles and Bronchiolitis Obliterans Syndrome. *Bronchiolitis Obliterans. *Other: Dosage of Microparticles (MPs) in ... L-CsA in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant (LT) Patients. *Bronchiolitis Obliterans ... Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS). *Bronchiolitis Obliterans ... Clinical Status and Bronchial Inflammation in Patients With Bronchiolitis Obliterans. *Bronchiolitis Obliterans ...
... addict who found the aroma of the freshly made snack to be irresistibly intoxicating has developed bronchiolitis obliterans, ... Explain there is now a report of a case of bronchiolitis obliterans found in a man whose only exposure to the chemical came ... The FDA has been studying the diacetyl issue since the first report of bronchiolitis obliterans among workers making microwave ... Heated diacetyl vaporizes and the vapor has been linked to bronchiolitis obliterans among flavoring, popcorn, and most recently ...
Bronchiolitis. Bronchiolitis Obliterans. Immune System Diseases. Bronchitis. Bronchial Diseases. Respiratory Tract Diseases. ... Montelukast to Treat Bronchiolitis Obliterans. The safety and scientific validity of this study is the responsibility of the ... Bronchiolitis Obliterans Chronic Graft Versus Host Disease Leukotriene Montelukast Stem Cell Transplant Drug: Singulair ( ... For bronchiolitis obliterans:. *Forced expiratory volume 1 (FEV1) less than or equal to 75 percent of predicted by pulmonary ...
... the qualifying term bronchiolitis obliterans (BO) is added. ... Linear opacities on HRCT in bronchiolitis obliterans organising ... encoded search term (Imaging in Bronchiolitis Obliterans Organizing Pneumonia) and Imaging in Bronchiolitis Obliterans ... Imaging in Bronchiolitis Obliterans Organizing Pneumonia. Updated: Jan 07, 2016 * Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, ... Bronchiolitis obliterans organizing pneumonia. Arch Intern Med. 2001 Jan 22. 161(2):158-64. [Medline]. [Full Text]. ...
The term bronchiolitis obliterans refers to swirls or plugs of fibrous, granulation tissue filling the small bronchiole airways ... Bronchiolitis obliterans organizing pneumonia, 25 years: a variety of causes, but what are the treatment options? Expert Rev ... Bronchiolitis obliterans organizing pneumonia (BOOP) is a rare inflammatory lung disorder which was first described in the ... Bronchiolitis Obliterans Organizing Pneumonia. NORD gratefully acknowledges ONeil Green, MD, Critical Care Medicine and ...
Idiopathic bronchiolitis obliterans organizing pneumonia with peripheral infiltrates on chest roentgenogram.. Bartter T1, Irwin ... revealed typical changes of bronchiolitis obliterans organizing pneumonia (BOOP) as the predominant finding in all cases, two ... Bronchiolitis Obliterans Organizing Pneumonia - Genetic Alliance. *Bronchiolitis Obliterans - Genetic Alliance. *Lung Diseases ...
Bronchiolitis obliterans organizing pneumonia. Retrieved on 2007-10-29. *↑ 2.0 2.1 Epler GR (2001). "Bronchiolitis obliterans ... Bronchiolitis obliterans organizing pneumonia (BOOP) is defined as "A disease formerly considered a form of interstitial ... Macartney C, Burke E, Elborn S, et al (2005). "Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkins ... Biehn SE, Kirk D, Rivera MP, Martinez AE, Khandani AH, Orlowski RZ (2006). "Bronchiolitis obliterans with organizing pneumonia ...
Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans-organizing pneumonia.. Myers JL1 ... The ultrastructural features of idiopathic bronchiolitis obliterans-organizing pneumonia (BOOP) were studied in 9 patients. As ... Bronchiolitis Obliterans Organizing Pneumonia - Genetic Alliance. *Bronchiolitis Obliterans - Genetic Alliance. *Pneumonia - ...
Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology. Hamidun Bunawan,1 Siti Noraini Bunawan,2 Syarul ... G. U. Hung, S. C. Tsai, J. F. Hsieh, C. H. Kao, and S. J. Wang, "Detect bronchiolitis obliterans due to Sauropus androgynus ... R.-S. Lai, A. A. Chiang, M.-T. Wu et al., "Outbreak of bronchiolitis obliterans associated with consumption of Sauropus ... H. Hsu, H. Chang, and Y. Goan, "Intermediate results in Sauropus androgynus bronchiolitis obliterans patients after single-lung ...
L. A. Pérez de Llano, A. V. Racamonde, M. J. Bande, M. O. Piquer, F. B. Nieves, and A. R. Feijoo, "Bronchiolitis obliterans ... W. L. Castleman, "Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection," The ... Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection. Ching-Chang Cheng,1 ... G. R. Epler, "Bronchiolitis obliterans organizing pneumonia: definition and clinical features," Chest, vol. 102, supplement 1, ...
Bronchiolitis obliterans is a serious, irreversible lung condition. It can develop after exposure to toxic fumes or after ... Causes of Bronchiolitis Obliterans. In some people, its not clear what causes bronchiolitis obliterans. However, several ... Bronchiolitis obliterans is not the same condition as bronchiolitis obliterans organizing pneumonia, despite the similar names ... is the best way to diagnose bronchiolitis obliterans.. When you have bronchiolitis obliterans, your lung function may decline ...
Endemic bronchiolitis obliterans syndrome in microwave popcorn workers: a new occupational lung hazard.. ... The exposure-related excess lung disease in this plant population is e best explained by work-related bronchiolitis obliterans ...
  • In animals 1 to 2 weeks after in vivo transfection of prepro-ET-1 gene, hyperplastic connective tissue plaque was seen in the alveolar duct and small conducting airway, indicating histologically distinctive bronchiolitis obliterans. (elsevier.com)
  • Bronchiolitis obliterans (OB) is a lesion that results when injury to small conducting airways is repaired by a proliferation of fibrous granulation tissue. (elsevier.com)
  • The expiratory images of high resolution computed tomography showed air trapping, indicating the presence of asymptomatic but gradually progressive bronchiolitis obliterans. (elsevier.com)
  • In 2000, inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. (nih.gov)
  • Explain there is now a report of a case of bronchiolitis obliterans found in a man whose only exposure to the chemical came from heavy daily consumption of microwave popcorn. (medpagetoday.com)
  • DENVER, Sept. 5 -- A microwave-popcorn addict who found the aroma of the freshly made snack to be irresistibly intoxicating has developed bronchiolitis obliterans, suggested a pulmonologist here. (medpagetoday.com)
  • Bronchiolitis obliterans became better known in 2000 when Missouri health officials asked the federal Centers for Disease Control and Prevention (CDC) to help them investigate cases in former microwave popcorn plant workers from Jasper, Mo. (verywell.com)
  • Endemic bronchiolitis obliterans syndrome in microwave popcorn workers: a new occupational lung hazard. (cdc.gov)
  • A patient with bronchiolitis obliterans may experience shortness of breath and have a dry cough, he/she may also be wheezing a lot. (medicalnewstoday.com)
  • Penicillamine therapy has been implicated as a possible cause of bronchiolitis obliterans in patients with rheumatoid arthritis . (healthcentral.com)
  • Despite lung transplantation being a possible cause of bronchiolitis, treatment with a lung transplant may be considered when the condition is caused by toxin exposure. (verywellhealth.com)
  • In 2015, CDC also identified workers from a coffee processing facility who suffer from bronchiolitis obliterans. (verywell.com)
  • In adults, older children, and some infants, bronchiolitis viruses causes symptoms similar to a mild cold-runny nose, stuffy head, and mild cough . (thefreedictionary.com)
  • Because bronchiolitis obliterans often develops in response to toxin exposure or as a transplant complication, you may experience other associated symptoms. (verywellhealth.com)
  • Treatment of bronchiolitis is usually focused on the symptoms instead of the infection itself since the infection will run its course and complications are typically from the symptoms themselves. (wikipedia.org)
  • This first came to public attention when eight former employees of the Gilster-Mary Lee popcorn plant in Jasper, Missouri, developed bronchiolitis obliterans. (wikipedia.org)
  • Explain to interested patients that reports of a progressive lung disease -- bronchiolitis obliterans -- among workers in snack food, flavoring, and now chemical plants has sparked interest in what has been dubbed "popcorn lung. (medpagetoday.com)
  • From those cases, bronchiolitis obliterans earned the nickname 'popcorn lung. (verywell.com)
  • Artificial butter flavoring appears to be causing a rare lung disease called bronchiolitis obliterans in workers in a popcorn plant in Missouri who have been inhaling its fumes. (thefreedictionary.com)
  • Unfortunately, one of the largest risks of a lung transplant is a recurrence of bronchiolitis obliterans, aka popcorn lung . (expertvaping.com)
  • Because of the specific link to the artificial butter flavoring used in popcorn, an odor we all know well, bronchiolitis obliterans came to be known as popcorn lung or popcorn workers lung . (expertvaping.com)
  • The term bronchiolitis obliterans refers to swirls or plugs of fibrous, granulation tissue filling the small bronchiole airways. (rarediseases.org)
  • A surgical lung biopsy , in which your surgeon removes a small piece of tissue from your lung to examine under a microscope, is the best way to diagnose bronchiolitis obliterans. (verywell.com)
  • b) Bronchiolitis obliterans on a transbronchial biopsy with complete luminal obliteration. (ersjournals.com)
  • The disease is suggestive of bronchiolitis obliterans or emphysema. (cdc.gov)