Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Diseases caused by factors involved in one's employment.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
Spasm of the large- or medium-sized coronary arteries.
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Measurement of volume of air inhaled or exhaled by the lung.
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Immunologic techniques involved in diagnosis.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Conjunctivitis due to hypersensitivity to various allergens.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
An absence of warmth or heat or a temperature notably below an accustomed norm.
Four or five slender jointed digits in humans and primates, attached to each HAND.
Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
The TEMPERATURE at the outer surface of the body.
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
The fertilizing element of plants that contains the male GAMETOPHYTES.
Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
The privacy of information and its protection against unauthorized disclosure.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The study of natural phenomena by observation, measurement, and experimentation.
The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.

Respiratory symptoms among glass bottle workers--cough and airways irritancy syndrome? (1/1269)

Glass bottle workers have been shown to experience an excess of respiratory symptoms. This work describes in detail the symptoms reported by a cohort of 69 symptomatic glass bottle workers. Symptoms, employment history and clinical investigations including radiology, spirometry and serial peak expiratory flow rate records were retrospectively analyzed from clinical records. The results showed a consistent syndrome of work-related eye, nose and throat irritation followed after a variable period by shortness of breath. The latent interval between starting work and first developing symptoms was typically 4 years (median = 4 yrs; range = 0-28). The interval preceding the development of dysponea was longer and much more variable (median = 16 yrs; range = 3-40). Spirometry was not markedly abnormal in the group but 57% of workers had abnormal serial peak expiratory flow rate charts. Workers in this industry experience upper and lower respiratory tract symptoms consistent with irritant exposure. The long-term functional significance of these symptoms should be formally investigated.  (+info)

Dose-response slope of forced oscillation and forced expiratory parameters in bronchial challenge testing. (2/1269)

In population studies, the provocative dose (PD) of bronchoconstrictor causing a significant decrement in lung function cannot be calculated for most subjects. Dose-response curves for carbachol were examined to determine whether this relationship can be summarized by means of a continuous index likely to be calculable for all subjects, namely the two-point dose response slope (DRS) of mean resistance (Rm) and resistance at 10 Hz (R10) measured by the forced oscillation technique (FOT). Five doses of carbachol (320 microg each) were inhaled by 71 patients referred for investigation of asthma (n=16), chronic cough (n=15), nasal polyposis (n=8), chronic rhinitis (n=8), dyspnoea (n=8), urticaria (n=5), post-anaphylactic shock (n=4) and miscellaneous conditions (n=7). FOT resistance and forced expiratory volume in one second (FEV1) were measured in close succession. The PD of carbachol leading to a fall in FEV1 > or = 20% (PD20) or a rise in Rm or R10 > or = 47% (PD47,Rm and PD47,R10) were calculated by interpolation. DRS for FEV1 (DRSFEV1), Rm (DRSRm) and R10 (DRSR10) were obtained as the percentage change at last dose divided by the total dose of carbachol. The sensitivity (Se) and specificity (Sp) of DRSRm, DRS10 delta%Rm and delta%R10 in detecting spirometric bronchial hyperresponsiveness (BHR, fall in FEV1 > or = 20%) were assessed by receiver operating characteristic (ROC) curves. There were 23 (32%) "spirometric" reactors. PD20 correlated strongly with DRSFEV1 (r=-0.962; p=0.0001); PD47,Rm correlated significantly with DRSRm (r=-0.648; p=0.0001) and PD47,R10 with DRSR10 (r=-0.552; p=0.0001). DRSFEV1 correlated significantly with both DRSRm (r=0.700; p=0.0001) and DRSR10 (r=0.784; p=0.0001). The Se and Sp of the various FOT indices to correctly detect spirometric BHR were as follows: DRSRm: Se=91.3%, Sp=81.2%; DRSR10: Se=91.3%, Sp=95.8%; delta%Rm: Se=86.9%, Sp=52.1%; and delta%R10: Se=91.3%, Sp=58.3%. Dose-response slopes of indices of forced oscillation technique resistance, especially the dose-response slope of resistance at 10Hz are proposed as simple quantitative indices of bronchial responsiveness which can be calculated for all subjects and that may be useful in occupational epidemiology.  (+info)

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (3/1269)

Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper respiratory tract infection, were randomly selected from a large-scale epidemiological survey in Central Norway. All were investigated with flow-volume spirometry, methacholine provocation test, allergy testing and measurement of nasal and exhaled NO concentration in the nonpollen season. Eighteen rhinitic subjects completed an identical follow-up investigation during the following pollen season. Exhaled NO was significantly elevated in allergic rhinitis in the nonpollen season, especially in perennially sensitized subjects, as compared with controls (p=0.01), and increased further in the pollen season (p=0.04), mainly due to a two-fold increase in those with seasonal sensitization. Nasal NO was not significantly different from controls in the nonpollen season and did not increase significantly in the pollen season. Exhaled NO was increased in hyperresponsive subjects, and decreased significantly after methacholine-induced bronchoconstriction, suggesting that NO production occurs in the peripheral airways. In allergic rhinitis, an increase in exhaled nitric oxide on allergen exposure, particularly in hyperresponsive subjects, may be suggestive of airway inflammation and an increased risk for developing asthma.  (+info)

Bradykinin-induced bronchospasm in the rat in vivo: a role for nitric oxide modulation. (4/1269)

Bradykinin has an important role in asthma pathogenesis, but its site of action is unclear. It was previously reported by the authors that bradykinin causes a dose-dependent reduction in dynamic compliance but little change in total lung resistance. This suggested that bradykinin may have a preferential effect in the distant lung. The purpose of the current investigation was to better characterize the effects of bradykinin on pulmonary resistance in rodents and explore the role of nitric oxide release in modulating the effect of bradykinin. Airway constriction was induced in the rats by aerosol administration of bradykinin with or without treatments with the inhaled bradykinin-2 receptor antagonist, Hoe 140 or the nitric oxide synthase inhibitors N(G)-nitro-L-arginine methylester or N(G)-monomethyl-L-arginine. Total lung resistance was partitioned into tissue and airway resistance by using the alveolar capsule method. Bradykinin induced a significant increase in both resistances. Hoe 140 abolished the response to bradykinin. The nitric oxide synthase inhibitors enhanced the bronchoconstricting response. In conclusion, the bradykinin response in the rats was not only localized to conducting airways but also involved a relatively selective tissue reaction. Bradykinin-induced bronchospasm in the rat is solely due to activation of bradykinin-2 receptor. Further, it was shown that nitric oxide significantly modulates the bronchospasm caused by bradykinin, suggesting that nitric oxide is an important modulator of airways responsiveness to bradykinin.  (+info)

Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis. (5/1269)

BACKGROUND: Inhaled corticosteroids are the most efficacious anti-inflammatory drugs in asthma. International guidelines also advocate the early introduction of inhaled corticosteroids in corticosteroid naive patients. A study was undertaken to assess the effects of inhaled corticosteroids on bronchial hyperresponsiveness in patients with corticosteroid naive asthma by conventional meta-analysis. METHODS: A Medline search of papers published between January 1966 and June 1998 was performed and 11 papers were selected in which the patients had no history of treatment with inhaled or oral corticosteroids. Bronchial responsiveness to bronchoconstricting agents was considered as the main outcome parameter. Doubling doses (DD) of histamine or methacholine were calculated. RESULTS: The total effect size of inhaled corticosteroids (average daily dose 1000 microg) versus placebo in the 11 studies was +1.16 DD (95% confidence interval (CI) +0.76 to +1.57). When only the eight short term studies (2-8 weeks) were analysed the effect size of the bronchoconstricting agent was +0.91 DD (95% CI +0.65 to +1.16). No relationship was found between the dose of inhaled corticosteroid used and the effect on bronchial responsiveness. CONCLUSION: This meta-analysis in patients with corticosteroid naive asthma indicates that, on average, high doses of inhaled corticosteroids decrease bronchial hyperresponsiveness in 2-8 weeks. It remains unclear whether there is a dose-response relationship between inhaled corticosteroids and effect on bronchial hyperresponsiveness.  (+info)

Update on the "Dutch hypothesis" for chronic respiratory disease. (6/1269)

BACKGROUND: Many patients with chronic obstructive lung disease show increased airways responsiveness to histamine. We investigated the hypothesis that increased airways responsiveness predicts the development and remission of chronic respiratory symptoms. METHODS: We used data from 24-year follow-up (1965-90) of 2684 participants in a cohort study in Vlagtwedde and Vlaardingen, Netherlands. Increased airways responsiveness was defined as a PC10 value (concentration of histamine for which challenge led to a 10% fall in forced expiratory volume in 1 s) of less than 8 mg/ml. Information on respiratory symptoms was collected by means of a standard questionnaire every 3 years. Logistic regression was used to control for age, area of residence, cigarette smoking status, and sex. FINDINGS: Participants with increased airways responsiveness (1281 observations) were more likely than those without increased airways responsiveness (5801 observations) to develop the following symptoms during any 3-year follow-up interval: chronic cough (odds ratio 1.9 [95% CI 1.2-2.9]), chronic phlegm (2.0 [1.3-3.0]), dyspnoea (2.3[1.5-3.5]), asthmatic attacks (3.7[2.2-6.1]), and persistent wheeze (2.7[1.7-4.4]). The estimate of the odds ratio for the development of any of the six symptoms was 1.7 (1.2-2.3). Participants with increased airways responsiveness were less likely than those without this characteristic to show remission of these respiratory symptoms. The estimate of the odds ratio for the remission of any of the six symptoms was 0.42 (0.28-0.61). INTERPRETATION: These prospective analyses show that increased airways responsiveness is positively associated with the development of chronic respiratory symptoms and negatively associated with the remission of these symptoms in adults.  (+info)

Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma. (7/1269)

BACKGROUND: It has been reported that pranlukast reduces the antigen induced immediate and late phase asthmatic responses, airway hyperreactivity to acetylcholine, and pulmonary eosinophil accumulation in guinea pigs. A study was undertaken to test the hypothesis that pranlukast may reduce the number of inflammatory cells in the bronchial mucosa of patients with asthma. METHODS: A double blind, placebo controlled study was performed in 17 mild to moderate asthmatic subjects to examine changes in inflammatory cell infiltration in response to pranlukast (225 mg orally twice per day for four weeks). Comparisons of the mean daily beta 2 agonist use, symptom score, FEV1 percentage predicted, and airway methacholine responsiveness were made before and after treatment. Using fibreoptic bronchoscopy, bronchial biopsy specimens were obtained before and after treatment with either pranlukast (n = 10) or placebo (n = 7). Immunohistology was performed using monoclonal antibodies for CD3, CD4, CD8, CD68, NP57, AA1, EG1, EG2, gamma GTP and CD19. RESULTS: When the pranlukast and placebo treated groups were compared there were decreases in beta 2 agonist use, symptom score, and airway methacholine responsiveness after pranlukast but no increase in FEV1 was seen. The clinical response in patients treated with pranlukast was accompanied by a reduction in CD3 (median difference -37, 95% confidence interval (CI) -69 to -1; p < 0.05), CD4 (median difference -28, 95% CI -49 to -8; p < 0.01), AA1 (median difference -15, 95% CI -26 to 0; p < 0.05) and EG2 positive cells (95% CI -35 to 0; p < 0.05), but not in EG1 positive eosinophils, gamma GTP positive cells, and CD19 positive plasma cells. CONCLUSIONS: These results support the view that pranlukast may act by inhibition of bronchial inflammation in patients with asthma.  (+info)

Clearance in small ciliated airways in allergic asthmatics after bronchial allergen provocation. (8/1269)

BACKGROUND: Asthma tends to affect mucociliary clearance, as assessed from measurements in large airways. However, there is no knowledge about clearance in the smallest airways of the tracheobronchial region in acute exacerbation of asthma. OBJECTIVE: The aim of the study was to investigate clearance from the bronchiolar region in patients with allergic asthma in a situation resembling a mild acute exacerbation of the disease. We also aimed to compare clearance data with corresponding data found for healthy subjects and asthmatics on therapy. METHODS: Tracheobronchial clearance was studied twice in 9 patients with mild asthma of the allergic type after inhalation of 6 microm (aerodynamic diameter) monodisperse Teflon particles labelled with 111In. At one exposure, inhalation was performed 4 h after bronchial provocation with an allergen the patients were allergic to. The second exposure was a control measurement. The particles were inhaled at an extremely slow flow, 0.05 liter/s, which gives deposition mainly in the small ciliated airways (bronchioles). Lung retention was measured at 0, 24, 48 and 72 h. RESULTS: All patients demonstrated an early asthmatic reaction of varying degree after bronchial provocation. There was significant clearance of radioaerosol in each 24-hour period for both exposures, with the possible exception of the period between 24 and 48 h for the provocation exposure, with similar fractions of retained particles at all points of time. The retained fractions were significantly larger compared to a group of healthy subjects and asthmatics on regular treatment with anti-inflammatory drugs. CONCLUSIONS: Our results indicate that in allergic asthmatics a bronchial allergen provocation with an early asthmatic reaction does not significantly influence overall clearance from the bronchiolar region. However, in the present group of patients, retention in small ciliated airways was significantly higher compared to healthy subjects and asthmatics on regular treatment.  (+info)

Assessment of airway responsiveness by bronchoprovocation and bronchodilatation tests is important in the diagnostic work-up protocol of bronchial asthma and it would be convenient to undertake both tests on the same occasion. However, it is not known whether this can be done accurately. Therefore, this study evaluated the effect of a prior bronchial provocation test on the bronchodilator response to salbutamol after spontaneous recovery of the forced expiratory volume in one second (FEV1) in a group of asthmatic subjects. On two separate occasions at the same time of day, concentration-response studies with inhaled histamine or methacholine, or a sham challenge with normal saline were carried out in a blinded, randomized manner. Changes in airway calibre were followed as FEV1 and agonist responsiveness expressed as the provocative concentration causing a 20% fall in FEV1 (PC20). After either spontaneous recovery or a fixed-duration wait of 45 min (when appropriate), the subjects received 2x100 ...
The incidence of asthma is increasing at an alarming rate. While the current available therapies are effective, there are associated side effects and they fail to adequately control symptoms in all patient subsets. In the search to understand disease pathogenesis and find effective therapies hypotheses are often tested in animal models before progressing into clinical studies. However, current dogma is that animal model data is often not predictive of clinical outcome. One possible reason for this is the end points measured such as antigen-challenge induced late asthmatic response (LAR) is often used in early clinical development, but seldom in animal model systems. As the mouse is typically selected as preferred species for pre-clinical models, we wanted to characterise and probe the validity of a murine model exhibiting an allergen induced LAR. C57BL/6 mice were sensitised with antigen and subsequently topically challenged with the same antigen. The role of AlumTM adjuvant, glucocorticoid, long acting
Specific Challenges to Data Collection Data collection poses specific challenges, including accessibility, trust, and user motivation. The following sections discuss how these issues affected our design. Challenges of Accessibility Advocates … - Selection from Beautiful Data [Book]
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The Respiratory Laboratory Scientist will explain and coach you through the testing process.. Test 1- Spirometry, Pre and Post bronchodilator:. This involves you blowing into a machine to see how much air you can blow out, how fast you can blow it out and whether or not it is better after administering a bronchodilator like Ventolin.. Test 2- Gas Diffusion (CO Uptake):. This test is used to determine the health of your lung tissue. It investigates how effectively oxygen is able to pass across the lung membrane and into the blood stream. This test involves you breathing into a machine and holding your breath.. Test 3- Bronchial Provocation Tests:. This test is performed to diagnose whether or not you have asthma. It simply involves you inhaling a spray or fine sugar powder at low, controlled doses to test the sensitivity of your airways.. Test 4- Exercise test for oxygen supplementation:. This is also known as a 6 Minute Walk Test and your doctor may wish for you to have one in order to see how ...
Concentration of methacholine (mg/ml) at which participants forced expired volume in 1 sec (FEV1) is reduced by 20% (the provocation concentration of methacholine causing a 20% fall in FEV1-PC20).. To measure if there is a significant difference in PC20 recorded at baseline to that recorded following 8 weeks treatment with omeprazole and ranitidine ...
Our study made a preliminary demonstration that the finding of obstruction based on the FEV1/FVC in the setting of a normal FEV1 (defined in this study as greater than 90% of predicted) does not consistently represent a normal physiologic variant. Nearly 28% of tested patients met criteria for AHR by either BD response or bronchoprovocation testing, irrespective of the presence or absence of symptoms. While there were no significant differences in AHR for those patients with an FEV1 , 100% of predicted versus ≥ 100% of predicted, the overall trend demonstrated a decreased frequency of AHR for an FEV1 ≥ 100% of predicted, as 80% of patients with evidence of AHR had an FEV1 , 100%. This becomes important in correlating the clinical suspicion for underlying disease with the indication (screening vs symptomatic) for PFT. Conversely, even in the presence of active pulmonary symptoms or established diagnoses, nearly 75% of patients tested did not demonstrate a significant BD response. This might ...
Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble interleukin-2 receptor, and interleukin-6 in asthmatic children ...
TY - JOUR. T1 - Methacholine inhalation challenge studies in a selcted pediatric population. AU - Hopp, R. J.. AU - Bewtra, A. K.. AU - Nair, N. M.. AU - Watt, G. D.. AU - Townley, R. G.. PY - 1986. Y1 - 1986. N2 - To determine bronchial reactivity patterns, 400 subjects, 5 to 21 yr of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or allergy was based on a respiratory questionnaire. Subjects were nonsmokers and had had no respiratory infections for 1 month. Intradermal skin tests were done. The methacholine challenge response was expressed as the area beneath the dose-response curve (Area35). Fifty-five asthmatics, 113 normal subjects from normal families, 103 normal subjects from asthma families, 60 normal twins, and 69 allergic subjects without asthma were studied. Overall, 52% of nonasthmatics and 47% of nonallergic subjects had an Area35 less than 4,000 (800 breath units). There was a difference (p , 0.05) in the distribution of ...
TY - JOUR. T1 - Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. AU - Avila, P. C.. AU - Boushey, H. A.. AU - Wong, H.. AU - Grundland, H.. AU - Liu, J.. AU - Fahy, J. V.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background: Selectins participate in the initial phase of leucocyte migration from circulation to inflamed tissues and may play a role in inflammatory cellular influx into airways in asthma. In the sheep asthma model, TBC1269, a pan-selectin antagonist, reduced late allergen response by 74%. Objective: To determine whether a single dose of TBC1269 inhibits early (EAR) and late (LAR) asthmatic responses, and whether it inhibits sputum leucocyte influx after inhalation allergen challenge in atopic asthmatic subjects treated with bronchodilators only. Methods: Twenty-one asthmatic subjects (mean ± SD, age = 32.5 ± 6.7 years, 8 males, FEV1 percent predicted = 84 ± 15%) with known late asthmatic response based on a screening inhalation allergen ...
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways). Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Health Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. Bronchial hyperresponsiveness has been associated with gas cooking among subjects ...
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways).. Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold.. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Heart Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. ...
As the usual bronchial provocation tests with methacholine are rather cumbersome and time-consuming, an attempt has been made to develop a short screening test for routine use. 143 patients with chronic cough or intermittent dyspnea received methacholine from a pressurised aerosol (puffer). The response was evaluated by spirometric measurement. Among 74 patients with chronic cough, 49 had a favourable response to methacholine. 93% were treated successfully with a bronchodilator. Among 62 patients with dyspnea, 45 reacted favourably to methacholine. All were treated successfully with bronchodilators. The short provocation test protocol with methacholine is easy and safe to perform. In cases of chronic cough and dyspnea it serves to detect hyperreactive patients who can benefit from bronchodilator treatment.
[Studies with experimental bronchospasm (histamine provocation test) for determination of the efficacy of an antihistaminic]. - H M Beumer
This is a Phase 3 study to determine the sensitivity and specificity of the Aridol bronchial challenge test to detect bronchial hyperresponsiveness in patients with suspected asthma. Patients with suspected asthma of either gender, aged between 6 and 50 years, with only mildly impaired lung function (FEV1 ,70%) are to be tested with three different bronchial hyperresponsiveness challenges (Aridol, exercise and methacholine), and the results compared. A clinical diagnosis will also be made at the end of the study ...
TY - JOUR. T1 - Investigative bronchoprovocation and bronchoscopy in airway diseases. AU - Busse, William W.. AU - Wanner, Adam. AU - Adams, Kenneth. AU - Reynolds, Herbert Y.. AU - Castro, Mario. AU - Chowdhury, Badrul. AU - Kraft, Monica. AU - Levine, Robert J.. AU - Peters, Stephen P.. AU - Sullivan, Eugene J.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - Rationale: Basic and clinical research strategies used for many lung diseases have depended on volunteer subjects undergoing bronchoscopy to establish access to the airways to collect biological specimens and tissue, perhaps with added bronchoprovocation in asthma syndromes. These procedures have yielded a wealth of important scientific information. Since the last critical review more than a decade ago, some of the techniques and applications have changed, and untoward events have occurred, raising safety concerns and increasing institutional review scrutiny. Objectives and Methods:To reappraise these investigational methods in the context of ...
Asthma is a heterogeneous disease and clinical phenotypes are highly variable. This is exemplified in the variability of patients responses to medications such as beclomethasone. It is a critical clinical question whether a particular therapy will be effective in an individual child with symptoms of asthma. At the moment, there is a lack of diagnostic tools to assess this individual responsiveness. Beclomethasone is an inhaled corticosteroid (ICS) used as controller therapy in children with asthma, providing protection against bronchial hyperresponsiveness (BHR) and exercise induced bronchoconstriction (EIB). A single dose of an ICS can have a significant effect on BHR measured by a bronchial provocation test (BPT). This rapid response shows variability similar to the variable responsiveness to long term treatment. We hypothesized that the effect of a single dose of beclomethasone on a BPT (a mannitol challenge) could predict the effect of longterm therapy with beclomethasone on BHR ...
Dr. Anand responded: Methacholine test. The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut.
Walsh SL, Wells AU, Desai SR, Poletti V, Piciucchi S, Dubini A, Nunes H, Valeyre D, Brillet PY, Kambouchner M, Morais A, Pereira JM, Moura CS, Grutters JC, van den Heuvel DA, van Es HW, van Oosterhout MF, Seldenrijk CA, Bendstrup E, Rasmussen F, Madsen LB, Gooptu B, Pomplun S, Taniguchi H, Fukuoka J, Johkoh T, Nicholson AG, Sayer C, Edmunds L, Jacob J, Kokosi MA, Myers JL, Flaherty KR, Hansell DM, Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study., Lancet respiratory, 2016;:557-565,10.1016/S2213-2600(16)30033-9 ...
Smiths Medical Asthma Patient Testing Kit (Methacholine Bronchoprovocation) is a convenient, all-inclusive procedural kit for the assessment of the respiratory
TY - JOUR. T1 - A comparison between different methods for detecting bronchial hyperreactivity. Bronchial hyperreactivity. T2 - methods of study.. AU - Grassi, C.. AU - Casali, L.. AU - Rossi, A.. AU - Rampulla, C.. AU - Zanon, P.. AU - Cerveri, I.. AU - Mastroberardino, M.. PY - 1980. Y1 - 1980. N2 - The authors evaluated bronchial hyperreactivity comparing two different methods for aspecific bronchostimulation (H2O ultrasonic mist and free running) and a bronchodilation test. The investigation had been carried out on three groups of subjects. The first included 15 nonsmoking normal subjects, the second 23 asthmatic patients and the third 16 rhinitic patients. All subjects were submitted to bronchodynamic tests in three different ways. The ventilatory parameters were FVC, FEV1, MMEF and Vmax25. In normal subjects no significant changes were found. In asthmatic patients the bronchodilation test was positive in 65% of the cases, regarding FEV1 and in 87% regarding the forced flows. The running ...
TY - JOUR. T1 - Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness. AU - Allen, Marcus. AU - Graham, P.. AU - Morris, G.. PY - 1996/3/1. Y1 - 1996/3/1. M3 - Article. VL - 45. SP - 118. EP - 122. JO - Inflammation Research. JF - Inflammation Research. SN - 1023-3830. IS - 3. ER - ...
Vandenplas O, Suojalehto H, Aasen T, Baur X, Burge PS, de Blay F, Fishwick D, Hoyle J, Maestrelli P, Muñoz X, Moscato G, Sastre J, Sigsgaard T, Suuronen K, Walusiak-Skorupa J, Cullinan P, the ERS Task Force on Specific Inhalation Challenges with Occupational Agents, Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement, Eur Respir J, 2014;43:1573-1587 ...
Occupational asthma (OA) is steadily emerging as the principal cause of respiratory disease due to the workplace environment. One of the key means to ascertain diagnosis of OA is specific inhalation challenge (SIC) with occupational agents. This review: 1) describes the methodology of SIC, with a special emphasis on procedures aimed at increasing the safety and validity of these tests; and 2) outlines the roles of SIC in the diagnosis of OA in clinical and medicolegal assessment, epidemiological studies, surveillance programmes and the investigation of the pathophysiological mechanisms of asthma and OA. We discuss areas of future development, including the development of apparatus which allows exposure of subjects to low and stable concentrations of the occupational agent and the assessment of preventive procedures.. ...
CiteSeerX - Scientific documents that cite the following paper: Diesel exhaust enhances airway responsiveness in asthmatic subjects
TY - JOUR. T1 - Assessment of bronchial responsiveness following exposure to inhaled occupational and environmental agents. AU - Currie, G. P.. AU - Ayres, Jonathan Geoffrey. PY - 2004. Y1 - 2004. M3 - Article. VL - 23. SP - 75. EP - 81. JO - Toxicology. JF - Toxicology. SN - 0300-483X. ER - ...
Bronchoprovocation challenge testing is sometimes used to diagnose asthma if your lung function is normal but you have typical asthma symptoms.
Methacholine tests are widely used as a diagnostic aid for asthma. Their strength has been reputed to be the high sensitivity and very infrequent occurrence of ...
The curators will assemble challenge teams to address specific global issues in the developing and developed worlds, with short- and long-term goals for tackling pressing issues where serious progress is possible.. Solving the worlds most pressing challenges depends in part on the kind of daring innovations and ideas that MIT is known for - and in fields from water, food, energy, and human health to innovation and education, our faculty are pioneering new answers, MIT Provost Martin Schmidt says. But lasting solutions to intractable human problems demand ambitious, sustained collaborative action, and require, from us, new ways of working with the world. Through Solve, we are connecting new ideas for action with people who, together, have the power to spark and accelerate meaningful change.. The Solve event will include challenge working groups, student forums, and tours. The specific challenges associated with each pillar will be addressed at the Solve event, and work will continue ...
Welcome to Real Science Real Nutrition! In an effort to bring our customers the highest level of quality products at affordable prices, we have developed an online store that offers added convenience to our customers. We know that natural medicines, vitamins, and herbs play a key role in supporting many of the bodys functions. Whether youre looking to support cardiovascular function, immune function, digestion, or the specific challenges that men and women face, we have a targeted solution for you. Real Science Real Nutrition offers a complete line of professionally formulated, high quality nutritional and dietary supplements at your fingertips. With quick and safe shipping, your health and wellness products can be delivered right to your front door!
Welcome to Real Science Real Nutrition! In an effort to bring our customers the highest level of quality products at affordable prices, we have developed an online store that offers added convenience to our customers. We know that natural medicines, vitamins, and herbs play a key role in supporting many of the bodys functions. Whether youre looking to support cardiovascular function, immune function, digestion, or the specific challenges that men and women face, we have a targeted solution for you. Real Science Real Nutrition offers a complete line of professionally formulated, high quality nutritional and dietary supplements at your fingertips. With quick and safe shipping, your health and wellness products can be delivered right to your front door!
While drinking trends for Whites tend to dominate views of overall drinking trends for the United States, Blacks and Hispanics often face specific challenges
MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level. While they have been implicated in various diseases, the profile changes in allergen inhalation challenge are not clarified in human. We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge. Seven mild asthmatic subjects participated in the allergen inhalation challenge. In addition, four healthy control subjects (HCs) were recruited. MicroRNA profiles in peripheral blood samples (pre-challenge and 2 hours post-challenge) were measured by the NanoString nCounter assay to determine changes in miRNA levels as these asthmatic subjects underwent an allergen inhalation challenge. One common miRNA, miR-192, was significantly expressed in both comparisons; HCs vs. pre-challenge and pre- vs. post-challenge, showing that miR-192 was significantly under-expressed in asthmatics compared to HCs and decreased in post-challenge at an
It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.. ...
TY - JOUR. T1 - Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing. AU - Wall, Michael. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 1989. Y1 - 1989. UR - http://www.scopus.com/inward/record.url?scp=0024572668&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024572668&partnerID=8YFLogxK. U2 - 10.1002/ppul.1950060203. DO - 10.1002/ppul.1950060203. M3 - Editorial. C2 - 2927974. AN - SCOPUS:0024572668. VL - 6. SP - 71. EP - 73. JO - Pediatric Pulmonology. JF - Pediatric Pulmonology. SN - 8755-6863. IS - 2. ER - ...
We investigated whether late asthmatic reactions and the associated increase in airway responsiveness induced by toluene diisocyanate (TDI) in sensitized subjects are inhibited by indomethacin and/or prednisone. Four sets of experiments were conducted in five subjects sensitized to TDI. To assess late asthmatic reactions to TDI, FEV1 was measured immediately before and after exposure to TDI and then hourly for 8 h. To assess change in airway responsiveness, the provocative dose (mg) of methacholine that caused a decrease in FEV1 of 20% (PD20FEV1) before treatment, and then before and after exposure to TDI was measured. In the first set of experiments, each subject was given no treatment and was studied before and 8 h after exposure to TDI; in the other two sets, each subject was studied before treatment, then during treatment with indomethacin (50 mg q.i.d. for 3 days, orally) or prednisone (50 mg once a day, for 3 days, orally), both before and 8 h after TDI exposure. In a fourth series of ...
Bronchial challenge tests are used to evaluate bronchial responsiveness in diagnosis and follow-up of asthmatic patients. Challenge induced cough has increasingly been recognized as a valuable diagnostic tool. Various stimuli and protocols have been employed. The aim of this study was to compare cough and dyspnea intensity induced by different stimuli. Twenty asthmatic patients underwent challenge tests with methacholine, bradykinin and exercise. Cough was counted during challenge tests. Dyspnea was assessed by modified Borg scale and visual analogue scale. Statistical comparisons were performed by linear mixed-effects model. For cough evaluation, bradykinin was the most potent trigger (p | 0.01). In terms of dyspnea measured by Borg scale, there were no differences among stimuli (p | 0.05). By visual analogue scale, bradykinin induced more dyspnea than other stimuli (p ≤ 0.04). Bradykinin seems to be the most suitable stimulus for bronchial challenge tests intended for measuring cough in association
In a study of 14 subjects with respiratory symptoms associated with exposure to live fish bait, skin- and serum-specific IgE tests with Lucilia caesar, Galleria mellonella, and Tenebrio molitor extracts were conducted. Thirteen subjects had asthma, all 14 had rhinoconjunctivitis, and 3 had contact urticaria. Eleven subjects had respiratory symptoms after fishing with live bait, and 3 subjects had symptoms during their work in a commercial fish bait farm. The presence of skin- or serum-specific IgE to L. caesar extract was demonstrated in 13 subjects, to G. mellonella extract in 4 subjects, and to T. molitor extract in 3 subjects. After exposure to live fish bait, 2 subjects had an early asthmatic response, 3 had a late asthmatic response, and 2 had no asthmatic response. Late asthmatic response was associated with a long-lasting increase in bronchial responsiveness (8 ...
Wheezing during infancy has been linked to early loss of pulmonary function. We prospectively investigated the relation between bronchial hyperresponsiveness (BHR) and progressive impairment of pulmonary function in a cohort of asthmatic infants followed until age 9 years. We studied 129 infants who had had at least three episodes of wheezing. Physical examinations, baseline lung function tests and methacholine challenge tests were scheduled at ages 16 months and 5, 7 and 9 years. Eighty-three children completed follow-up. Twenty-four (29%) infants had wheezing that persisted at 9 years of age. Clinical outcome at age 9 years was significantly predicted by symptoms at 5 years of age and by parental atopy. Specific airway resistance (sRaw) was altered in persistent wheezers as early as 5 years of age, and did not change thereafter. Ninety-five per cent of the children still responded to methacholine at the end of follow-up. The degree of BHR at 9 years was significantly related to current clinical status
A number of mechanisms have been proposed as the basis for the relationship between nonspecific airway responsiveness and prechallenge pulmonary function. Because resistance to flow through a tube is inversely proportional to the radius to the fourth power, a given degree of bronchoconstrictor-induced circumferential airway narrowing can be expected to cause a proportionally larger increase in airway resistance in a narrow airway than in a wider airway. Intersubject differences in the distribution of resistance along the bronchial tree may influence both the pattern of aerosol deposition and the relative impact on total airway resistance of bronchoconstriction at particular sites such as the peripheral airways. Airway hyperresponsiveness may result in heightened bronchomotor tone prior to challenge and thereby be correlated with reduced prechallenge pulmonary function. The convention of expressing responsiveness in terms of percentage of change in FEV, (eg, PD20FEV,) imposes a mathematical ...
TY - JOUR. T1 - Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging. T2 - A proof of concept study. AU - Renne, Julius. AU - Hinrichs, Jan. AU - Schönfeld, Christian. AU - Gutberlet, Marcel. AU - Winkler, Carla. AU - Faulenbach, Cornelia. AU - Jakob, Peter. AU - Schaumann, Frank. AU - Krug, Norbert. AU - Wacker, Frank. AU - Hohlfeld, Jens M.. AU - Vogel-Claussen, Jens. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours ...
The neurosurgical team has complete and primary control of the patients in the NICU and is therefore very closely involved in their management. Comprehensive monitoring capability is already in place and an excellent full-time research coordinator is on staff. The adult and pediatric hospital buildings are adjacent to each other and are connected by a cross walk. The same resident team covers both age groups. There is an excellent working relationship between the Neurosurgery team, the Trauma Surgery team and other associated services. Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2879175 • Bronchial provocation tests: the rationale for using inhaled mannitol as a test for airway hyperresponsiveness. Author(s): Leuppi JD, Brannan JD, Anderson SD. Source: Swiss Medical Weekly : Official Journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology. 2002 April 6; 132(13-14): 151-8. Review. cmd=Retrieve&db=pubmed&dopt=A ...
The 547 asymptomatic subjects with normal pulmonary function were grouped according to quintile of prechallenge FEV, (percent predicted), and the fifth percentiles of PD20FEV, within each quintile of FEV, were calculated (Table 2). The fifth percentile of methacholine PD20FEV, increased with increasing quintile of prechallenge FEV,. This relationship is shown graphically in Figure 1, in which the fifth percentile of PD20FEV, for each quintile is plotted against the median FEV, for that quintile. Restricting analysis to a subgroup of 157 lifetime nonsmokers yielded similar values for the fifth percentiles of PD20FEV,, for both overall and FEV,-specific percentiles (data not shown). canadian health & care mall. The overall fifth percentile of PD20FEV, (8.3 (imol) and the FEV,-specific fifth percentiles of PD20FEV, (as indicated in Table 2) respectively defined the 26 (4.8 percent) and 27 (4.9 percent) most responsive subjects among the 547 asymptomatic men. Seventeen (3.1 percent) men were ...
The aim of this study was to assess the effectiveness of an asthma prevalence video questionnaire, a standard written questionnaire based on the IUATLD Bronchial Symptoms Questionnaire and a new written questionnaire designed for an international study of asthma and allergies in childhood ISAAC in predicting bronchial hyper-responsiveness BHR...
TY - JOUR. T1 - Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge. AU - Hunt, L. W.. AU - Gleich, G. J.. AU - Kita, H.. AU - Weiler, D. A.. AU - Schroeder, D. R.. AU - Vuk Pavlovic, Z.. AU - Sur, Sanjiv. PY - 2002. Y1 - 2002. N2 - Background: In patients with quiescent asthma, macrophages are the most prevalent cells recovered by bronchoalveolar lavage (BAL). Through activation via their FcεRII receptors or by acting as antigen-presenting cells, macrophages could, in theory, promote the late airway response to allergen. Objective: In order to investigate the importance of macrophages and other airway luminal cells in inducing the late airway response, a novel washout experiment was designed. Methods: Five patients with ragweed-allergic asthma underwent bronchoscopy and segmental bronchial challenge with either normal saline or short ragweed extract in two segments of one lung. In a third segment of the opposite lung, 12 successive BALs ...
BACKGROUND: It has been postulated that dietary antioxidants may influence the expression of allergic diseases and asthma. To test this hypothesis a case-control study was performed, nested in a cross sectional study of a random sample of adults, to investigate the relationship between allergic disease and dietary antioxidants. METHODS: The study was performed in rural general practices in Grampian, Scotland. A validated dietary questionnaire was used to measure food intake of cases, defined, firstly, as people with seasonal allergic-type symptoms and, secondly, those with bronchial hyperreactivity confirmed by methacholine challenge, and of controls without allergic symptoms or bronchial reactivity. RESULTS: Cases with seasonal symptoms did not differ from controls except with respect to the presence of atopy and an increased risk of symptoms associated with the lowest intake of zinc. The lowest intakes of vitamin C and manganese were associated with more than fivefold increased risks of ...
Using a sensitive single isotope enzymatic assay we measured bronchoalveolar lavage (BAL) fluid histamine in asymptomatic normal (nonallergic), allergic rhinitic, and allergic asthmatic subjects. Normal subjects were found to have little or no detectable amounts of histamine in BAL fluid (11 +/- 11 pg/ml), and few BAL fluid mast cells. In comparison, the allergic rhinitics and allergic asthmatics had much higher amounts of BAL fluid histamine (113 +/- 53 and 188 +/- 42 pg/ml, respectively), and a significantly greater number of BAL fluid mast cells. Furthermore, despite having equivalent baseline pulmonary function values, allergic asthmatics with BAL fluid histamine levels greater than 100 pg/ml required only 7 +/- 2 breath units of methacholine to induce a 20% drop in forced expiratory volume in 1 s (FEV1) (PD20FEV1) while asthmatics with BAL fluid histamine levels less than 100 pg/ml required 49 +/- 19 breath units (P less than 0.05). These data suggest that allergic asthmatics have ongoing ...
PubMed journal article Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary diseas were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. In patients with mild asthma, quilizumab reduced serum IgE and attenuated the early and late asthmatic reaction following whole lung allergen challenge. This study evaluated the efficacy and safety of quilizumab in adults with allergic asthma, inadequately controlled despite high-dose inhaled corticosteroids (ICS) and a second controller. Five hundred seventy-eight patients were randomized to monthly or quarterly dosing regimens of subcutaneous quilizumab or placebo for 36 weeks, with a 48-week safety follow-up. Quilizumab was evaluated for effects on the rate of asthma exacerbations, lung function, patient symptoms, serum IgE, and pharmacokinetics. Exploratory analyses were conducted on biomarker subgroups (periostin, blood eosinophils, serum IgE, and exhaled nitric oxide). Quilizumab was well tolerated and reduced serum total and allergen
the history of asthma asthma tests for adults types of asthma mild persistent treatment for asthma asthma and anxiety asthma coughing dry asthma specialists richmond asthma tests methacholine symptoms of asthma in cats skin asthma clinic A bronchial challenge test is a medical test used to assist in the diagnosis...
Lung function assessments are critical to confirm a diagnosis of asthma and to assess for alternative diagnosis and comorbidity. Assessments include spirometry, bronchial provocation testing, forced oscillation technique and peak expiratory flow.
The contributions of histamine, cysteinyl leukotrienes (CysLTs) and thromboxane A,SUB,2,/SUB, (TXA,SUB,2,/SUB,) to the asthmatic responses and the magnitudes of blood and lung eosinophilia at acute and chronic stages of our asthmatic model were comparatively determined. Guinea pigs were alternately sensitized/challenged by inhalation with ovalbumin+Al(OH),SUB,3,/SUB, and ovalbumin, once every 2 weeks. Effects of mepyramine, pranlukast (a CysLT antagonist) and seratrodast (a TXA,SUB,2,/SUB, antagonist) on the early (EAR) and/or the late asthmatic response (LAR) were assessed at the second and fourth antigen challenges. The second challenge caused EAR but not LAR. Although the EAR was decreased at the fourth challenge, a substantial LAR was seen. Both mepyramine and seratrodast inhibited the EAR at the second challenge by approximately 50%. However, at the fourth challenge, these drugs did not inhibit the EAR. The LAR at the fourth challenge was attenuated by pranlukast and seratrodast by 45% and ...
The aim of this study was to assess prevalence of asthma and allergy in the non-polluted mountain area of Upper Hallingdal, Norway. All schoolchildren (7-16 years) who in a previous questionnaire survey (n = 1177) reported sometime asthma were enrolled in group I (n = 80), the 59 who reported asthma-like symptoms in the past 12 months formed group II, and 77 of the healthy controls were randomly selected as group III. All 216 children underwent clinical examination, skin prick test, spirometry, bronchial provocation (PD20 metacholine) and treadmill exercise test. Subsequently they were reclassified as (1) healthy, never had asthma or symptoms, (2) symptoms not confirmed as asthma, (3) previous asthma, now healthy, (4) current asthma. Lifetime asthma prevalence was 10.2%. Based upon clinical examination, the specificity and sensitivity of the questionnaire for asthma diagnosis were 88 and 74%, respectively. Forced vital capacity was significantly higher among the asthmatics (group 4 versus 1), ...
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In order to diagnose and monitor asthma, your healthcare provider examines you. He or she listens to your chest and asks you to breathe. You are asked questions about your symptoms, triggers, and any family history of asthma or allergies. Special lung function tests may also be done. One of these is called a spirometry test.. ...
Our study investigated if airway hyperresponsiveness (AHR) at asthma onset could predict FEV1 decline in treated asthmatics. We retrospectively recruited 275 subjects that had performed a methacholine test at asthma onset and FEV1 measurements after 5-10 years. We subdivided subjects into three groups, according to their AHR level. 65 patents had normal reactivity (25 males; mean age 46±15; mean baseline FEV1%:96.1±20); 78 were borderline/mild AHR (PD20,400µg) (26 males; mean age 43±14; mean baseline FEV1%:102±12; mean PD20:1120±696) and 132 showed moderate/severe AHR (PD20≤400µg; 51 males; mean age 43±14; mean baseline FEV1%: 94±13; mean PD20:185±108). Annual FEV1 declines (the differences between the first and last measurements, divided by the number of years separating them) were compared. Average annual FEV1 declines (after 7±2 years) were similar in all groups: 46.2±81 ml/yr in normal reactivity subjects, 53±65 in borderline/mild AHR and 45±62.5 in moderate/severe AHR ...
We investigated the potential role of intercellular-adhesion molecule-1 (ICAM-1) in allergen-induced bronchial hyperresponsiveness (BHR) and inflammation in sensitised Brown-Norway rats. Rats were sensitised with ovalbumin (OA) intraperitoneally and 21 days later they were either exposed to 0.9% NaCl or 1% OA aerosol for 15 min. Rats exposed to OA aerosol were pretreated either with ICAM-1 antibody (3 mg/kg i.p. and i.v., 45 min prior to OA exposure) or with the diluent for the antibody. Eighteen to twenty-four hours after OA or 0.9% NaCl exposure, rats were anaesthetised, tracheostomised and mechanically ventilated, and airway responsiveness to acetylcholine (ACh) aerosol was measured as the provocative concentration of ACh needed to increase pulmorary resistance by 100% (PC100). Mean -log PC100 was increased in rats exposed to OA but pretreated with diluent (2.75 +/- 0.06) compared to rats treated with ICAM-1 antibody (2.51 +/- 0.08 ...
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Methacholine, cold air and exercise challenge tests in the diagnosis of bronchial responsiveness at school age: A follow-up study from birth to school age ...
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Each of those have articles on the way to strengthen the public health. Each and every write-up is concerned having a certain disease or condition. They normally clarify how to manage the disease and what it requires to treat it.. Like the other scientific journals, all of the papers on public well being nursing use the term cluster to describe the situation. All these articles state that a cluster is the outcome of a variety of instances which can be associated. That signifies if 1 particular person has this specific challenge, it could bring about numerous others to obtain sick and also die.. writing essays help However, each case might not necessarily indicate a disease. Often people today that have the same symptoms could be finding superior. A further term for the cluster is the group of circumstances. Inside the New York Occasions post on how our nursing theories classified, a cluster of cases does not necessarily indicate a disease.. If an individual suffers from diabetes and also ...
There were concerns about the proposals in the Long-Term Plan to deliver healthcare digitally. A significant proportion of people Healthwatch spoke to have no online access, and other work in the past has suggested that some groups of Tameside residents have little motivation to get online or to become more digitally literate. If digital first and technology in healthcare are to be successful in Tameside, Healthwatch felt that a significant piece of work is needed to understand the specific challenges to this.. The survey results show that people want to tell providers and commissioners about their ideas, and want to see that these ideas have been useful when designing a service.. ...
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While men are prone to act on their anger, woman tend to renounce it. What are some of the specific challenges women face in dealing with anger?
A specific challenge we face in the course of the AETIONOMY project lies in the fact that for most neurodegenerative diseases the dysfunctional biological pathways underlying the disease are not known. AETIONOMY will therefore have to first define new routes towards the identification of the underlying disease mechanisms before organising these and proposing a rational disease taxonomy for Alzheimers and Parkinsons disease. Moreover, we will validate the mechanism-based taxonomy at least partially in the course of a prospective clinical study.. Visit project page:. ...
Populism has had as many incarnations as it has had provocations, but its constant ingredient has been resentment, and hence whininess.
... bronchial provocation tests MeSH E01.370.386.700.150 - capnography MeSH E01.370.386.700.250 - exercise test MeSH E01.370. ... Nasal provocation test MeSH E01.370.386.700 - respiratory function tests MeSH E01.370.386.700.050 - airway resistance MeSH ... intradermal tests MeSH E01.370.750.300.400 - kveim test MeSH E01.370.750.300.750 - skin test end-point titration MeSH E01.370. ... intradermal tests MeSH E01.450.495.750.300.540 - kveim test MeSH E01.450.495.750.300.750 - skin test end-point titration MeSH ...
... the nasal provocation testing necessary to diagnose the condition was not widely available. Prevention often focuses on ... This IL-33/ST2 signaling pathway has been found to be one of the main genetic determinants in bronchial asthma pathogenesis, ... Skin testing is the most common method of allergy testing. This may include a patch test to determine if a particular substance ... The intradermal allergy test is more sensitive than the skin prick test, but is also more often positive in people that do not ...
Rather than increase histamine during the test diet, eliminate it. This procedure does not endanger the patient. Quite the ... ISBN 978-3-7776-2349-8. "Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: ... However, since many complaints such as headaches, migraines, bronchial asthma, hypotension, arrhythmia and dysmenorrhea ( ... "Histamine intolerance: Causes, symptoms, and test". Medical News Today. Vogelreuter, Axel (2015). ...
He did not wait long after his admission into that assembly in bringing their predictions to the test. Parliament met on 19 ... For several years Cobden had been suffering severely at intervals from bronchial irritation and a difficulty of breathing. ... Napoleon was represented as contemplating a sudden and piratical descent upon the British coast without pretext or provocation ...
Witnesses said the policeman hit Davis in the stomach with a nightstick without provocation. Two detectives held the crowd back ... John's Hospital near his home in Santa Monica, California, for routine tests. Doctors suggested he have a tracheal tube ... implanted to relieve his breathing after repeated bouts of bronchial pneumonia. The suggestion provoked an outburst from Davis ...
... and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical ... Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of ...
Leukotriene D4 Bronchial Provocation Test (LTD4-BPT) as an Indicator for the Use of Leukotriene Receptor Antagonist (LTRA). The ... Could Leukotriene D4 Bronchial Provocation Test be a Clear Indicator for Predicting Therapeutic Outcomes of Leukotriene ... Objective4To investigate whether leukotriene D4 bronchial provocation test (LTD4-BPT) could be an indicator of actual ... We aimed to test whether there would be certain parameters that assist prediction of anticipated outcome. ...
Background The International Olympic Committee-Medical Commission (IOC-MC) accepts a number of bronchial provocation tests for ... The role of the bronchial provocation challenge tests in the diagnosis of exercise-induced bronchoconstriction in elite ... The role of the bronchial provocation challenge tests in the diagnosis of exercise-induced bronchoconstriction in elite ... elite swimmers were evaluated on separate days for the presence of EIB using 3 different bronchial provocation challenge tests ...
Antigen Bronchial Provocation Tests, Bronchial Allergen Challenge, Inhalation Provocation Tests. Scope note: Tests involving ... found: MeSH browser, June 12, 2007(Bronchial Provocation Tests. Entry terms: Allergen Bronchial Provocation Tests, Allergen ... "Bronchial provocation tests" to: * How many floors does a two-story house have?. ... Aas, Kjell, 1924- bronchial pr. Spector, Sheldon L. Provocatio. Spector, Sheldon L. Provocativ. ...
Adverse events were monitored and diaries kept for 7 days following the tests. Mean pre-test FEV1 (mean ± SD) was 95.5 ± 14% ... developed to improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests have an advantage ... Cough was common during testing. There were no serious adverse events. The diarised events were similar for mannitol and HS, ... Inhaled mannitol is a new bronchial provocation test (BPT) ... The bronchial provocation test that uses an aerosol of ...
... or pulmonary function or breathing tests, can show how well your lungs and airways are working, help diagnose respiratory ... Bronchial provocation test. A bronchial provocation test may be recommended to help diagnose asthma and determine its severity ... Other tests available at respiratory departments in teaching hospitals include exercise testing, bronchial provocation tests ( ... Lung function tests. Lung function tests, also called pulmonary function tests or breathing tests, are tests that can be done ...
The bronchial provocation test is used to assess lung function in both adults and children, and to diagnose lung diseases such ... Bronchial Provocation Test. The bronchial provocation test is used to assess lung function in both adults and children, and to ...
Role of astograph methacholine provocation test in diagnosis of bronchial asthma Role of astograph methacholine provocation ... Objective To evaluate the diagnostic value of astograph methacholine provocation test for bronchial asthma.Methods A total of ... asthma patients participated in the detection by astograph methacholine provocation test.Statistical methods were used to ... with a sensitivity of 0.693 and specificity of 0.684.Conclusion Astograph methacholine provocation test shows good sensitivity ...
OBJECTIVES: Bronchial provocation tests that assess airway hyperresponsiveness (AHR) are known to be useful in assisting the ... OBJECTIVES: Bronchial provocation tests that assess airway hyperresponsiveness (AHR) are known to be useful in assisting the ... We reviewed the use of bronchial provocation tests that use stimuli that act indirectly for monitoring the benefits of inhaled ... CONCLUSIONS: Non-responsiveness to indirect bronchial provocation tests following inhaled corticosteroids occurs weeks to ...
The methacholine bronchial provocation test (MBPT) is highly sensitive and widely used to detect and quantify AHR [3,4]. AHR ... 1. The methacholine bronchial provocation test (MBPT) is highly sensitive and has been widely used to detect and quantify ... MBPT, methacholine bronchial provocation test; BMI, body mass index; FEV1, forced expiratory volume in 1 second; pred., ... The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since ...
Thus evaluation of airway responsiveness by both bronchial provocation tests and bronchodilator testing can be assessed ... Thus evaluation of airway responsiveness by both bronchial provocation tests and bronchodilator testing can be assessed ... Therefore, this study evaluated the effect of a prior bronchial provocation test on the bronchodilator response to salbutamol ... Therefore, this study evaluated the effect of a prior bronchial provocation test on the bronchodilator response to salbutamol ...
Bronchial Hyperresponsiveness in Skiers: Field Test versus Methacholine Provocation?. STENSRUD, TRINE; MYKLAND, KJELL VEGARD; ...
Wall M. Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing. Pediatric pulmonology. ... Wall, M. (1989). Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing. Pediatric ... Wall, M 1989, Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing, Pediatric ... Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing. In: Pediatric pulmonology. 1989 ; ...
Bronchial Provocation or Challenge Tests. *Methacholine challenge: Methacholine is a known asthma trigger that, when inhaled, ... Pulmonary Function Tests (PFTs). Pulmonary function tests (PFTs) are a series of different breathing tests led by a trained ... Airway resistance is a test that measures how easy it is for the air to move in and out of your lungs. It is an easy test to do ... For this test, you may be asked to breathe quickly, forcefully, or slowly. The test is always repeated at least three times and ...
Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble ...
Methacholine Challenge Testing. Synonyms. Mecholyl challenge, bronchial provocation test. Indications. It is used diagnose ... Six-Minute Walk Test. Background. The six-minute walk test (6mwt) is a test that can aid in assessing the functional capacity ... ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. ... CPX test is used for evaluation of dyspnea that is out of proportion to findings on static pulmonary function tests, ...
Nonspecific bronchial hyperresponsiveness was diagnosed. A provocation test with dr … ... Nonspecific bronchial hyperresponsiveness was diagnosed. A provocation test with dry chicory induced acute rhinoconjunctivitis ... Skin prick test results were positive to birch pollen and fresh/dry chicory, and negative for inulin. Specific immunoglobulin ( ...
... bronchial symptoms questionnaire was completed by 827 subjects participating in a prospective study of respiratory symptoms and ... Bronchial Provocation Tests * Bronchoconstriction / physiology * Evaluation Studies as Topic * Humans * Methacholine Chloride ... Bronchial reactivity (BR) was measured in 809 subjects by methacholine challenge using a rapid method. Factor analysis ... The new International Union Against Tuberculosis (IUAT) bronchial symptoms questionnaire was completed by 827 subjects ...
Bronchial Provocation testing: Spirometry is used before and after inhalation of Methacholine spray to assess the sensitivity ... Pulmonary Exercise Tests We Perform:. *Six-Minute Walk Test: Walking test used to assess physical fitness and or the need for ... Please call directly for testing information at those locations.. Pulmonary Function Tests We Perform: *Spirometry: Measures ... High Altitude Simulation Testing: Used for some people with lung disease who are planning to travel in an airplane or who wish ...
Environmental allergy testing. Other tests may include:. *Bronchial Provocation Test. *Exercise-Induced Bronchoconstriction ... Pre-Admission Testing*During Your Stay*Leaving BIDMC*Billing and Financial Assistance*Medical Records*PatientSite*Conversation ... Your doctor may have you perform a number of tests to evaluate breathing. These may include:. *Detailed medical history and ...
Bronchial provocation test Make indication of and interpretation results of unspecific bronchial provocation test ... test of reversibility 3. Peak-flow monitoring Make indication and guidance for peak-flow monitoring, as well as read and ... The project can be based on already collected data that is suitable for the testing of certain hypotheses. The physician must ... The project can be based on already collected (Clinical data monitoring) that is suitable for the test of certain hypotheses. ...
Lung function test and bronchial provocation test. Spirometry is performed according to international standards [29]. The ... The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase ... as well as airway lability from the results of spirometry and bronchial provocation tests. Questionnaires regarding subjects ... Childhood Asthma Control Test (c-ACT) is used for subjects aged 5 to 11, and the Asthma Control Test is provided for those aged ...
The tests performed include:. *Blood gas analysis. *Bronchial provocation. *Bronchodilator responsiveness. *CPAP titration ... Testing. Diagnosis of some pulmonary diseases requires certain types of testing. Akron General offers a wide range of tests, ... Pulmonary function tests are specialized breathing tests performed to "fingerprint" the breathing cycle. These tests help to ... In addition to certain types of tests, sometimes pulmonary diseases can be diagnosed using non- invasive imaging, including:. * ...
... full pulmonary function tests with diffusing capacity of the lung for carbon monoxide testing should be ordered to confirm ... The severity of the abnormality is determined by the FEV1 (percentage of predicted). If pulmonary function test results are ... Office-based pulmonary function testing, also known as spirometry, is a powerful tool for primary care physicians to diagnose ... Bronchial provocation testing: the future. Curr Opin Allergy Clin Immunol. 2011;11(1):46-52. ...
bronchial provocation tests. *lung volume measurements. *chronic obstructive pulmonary disease. *genetics. *β2 adrenergic ... Differences in mean NSBH were compared by the Wilcoxon test since these data were not normally distributed. All tests were ... Tracey M, Villar A, Dow L, et al. The influence of increased bronchial responsiveness, atopy, and serum IgE on decline in FEV1 ... We also tested whether there was a relationship between these polymorphisms and NSBH measured using inhalation of methacholine ...
Bronchial Provocation Tests. Humans. Hydrogen-Ion Concentration. Male. Methacholine Chloride / diagnostic use. Mucociliary ...
Inovas pulmonary diagnostics program provides testing and treatment to assist referring healthcare providers with your lung ... Inovas pulmonary diagnostics program provides testing and treatment to assist referring healthcare providers with your lung ... Other Testing. *Arterial Blood Gas. *Bronchial Provocation Challenge. *Sputum Induction. Treatments. *Pentamidine Aerosol ... Tests and Treatments. Inovas Pulmonary Diagnostics Program offers the following tests and treatments:. Pulmonary Function ...
Whereas a high prevalence of bronchial abnormalities has been reported in endurance athletes, its underlying mechanisms and ... Bronchial Hyperreactivity / diagnosis*, epidemiology. Bronchial Provocation Tests. Bronchitis / diagnosis*, epidemiology. ... Both BHR and bronchial obstruction at rest with subsequent expiratory flow limitation during exercise may promote respiratory ... STUDY OBJECTIVES: The purpose of this study was to assess the following: (1) bronchial responsiveness to methacholine and to ...
Blood tests to look for antibodies to the substance. *Bronchial provocation test (test measuring reaction to the suspected ... Tests may be ordered to confirm diagnosis:. * ...
All undertook serial allergy tests and specific bronchial provocation testing. These patients developed occupational asthma ...
  • These tests are used in the diagnosis of asthma. (loc.gov)
  • Osmotic challenge tests have an advantage over the traditional methods of measuring airway hyperresponsiveness using methacholine as they demonstrate higher specificity to identify asthma and thus the need for treatment with inhaled corticosteroids (ICS). (biomedcentral.com)
  • Lung function tests are often used to help diagnose or assess asthma and chronic obstructive pulmonary disease (COPD) . (mydr.com.au)
  • Peak expiratory flow tests and spirometry are the main lung function tests done in children, often to diagnose or assess asthma. (mydr.com.au)
  • Spirometry is the most accurate test of lung function in people with asthma, and is also commonly used in people with COPD. (mydr.com.au)
  • Bronchodilator response test - where spirometry tests are done both before and after taking asthma reliever medicines, to see what effect they have on your results. (mydr.com.au)
  • The bronchial provocation test is used to assess lung function in both adults and children, and to diagnose lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). (biron.com)
  • Objective To evaluate the diagnostic value of astograph methacholine provocation test for bronchial asthma . (bvsalud.org)
  • Monitoring asthma therapy using indirect bronchial provocation tests. (mendeley.com)
  • OBJECTIVES: Bronchial provocation tests that assess airway hyperresponsiveness (AHR) are known to be useful in assisting the diagnosis of asthma and in monitoring inhaled corticosteroid therapy. (mendeley.com)
  • DATA SOURCE: Published clinical trials investigating the effect of inhaled corticosteroids on bronchial hyperresponsiveness in persons with asthma were used for this review. (mendeley.com)
  • Assessment of airway responsiveness by bronchoprovocation and bronchodilatation tests is important in the diagnostic work-up protocol of bronchial asthma and it would be convenient to undertake both tests on the same occasion. (unict.it)
  • Spirometry is a very common test to help you and your doctor understand your asthma better, and check how it is improving with treatment. (getasthmahelp.org)
  • The measurements taken from this test are key in helping your doctor diagnose asthma. (getasthmahelp.org)
  • Physicians will verify the relevant histories of asthma and comorbid diseases, as well as airway lability from the results of spirometry and bronchial provocation tests. (springer.com)
  • Questionnaires regarding subjects' baseline characteristics and their environment, self-rating of asthma control, and laboratory tests for allergy and airway inflammation will be collected at the time of enrollment. (springer.com)
  • If pulmonary function test results are normal, but the physician still suspects exercise- or allergen-induced asthma, bronchoprovocation (e.g., methacholine challenge, mannitol inhalation challenge, exercise testing) should be considered. (aafp.org)
  • Many organizations, including the National Asthma Education and Prevention Program, Global Initiative for Chronic Obstructive Lung Disease (GOLD), and American Thoracic Society (ATS), recommend using these tests. (aafp.org)
  • SOMC is offering an innovative new treatment to help patients suffering from chronic asthma called Bronchial Thermoplasty . (somc.org)
  • The evaluation of the work-relatedness of asthma in the exposed workers was based on serial peak expiratory flow rate (PEFR) measurements and bronchoprovocation tests. (srce.hr)
  • A patient with VCD shows no bronchial hyperresponsiveness on methacholine challenge unless he or she has concomitant asthma. (medscape.com)
  • Prognostic value of bronchial provocation and FENO measurement for asthma diagnosis--results of a delayed type of diagnostic study. (semanticscholar.org)
  • If sensitizer-induced occupational asthma is suspected, additional testing of asthma should be done, preferably while the patient is still working. (bmj.com)
  • Alexander HL, Paddock R. Bronchial asthma: response to pilocarpine and epinephrine. (springer.com)
  • Bronchial asthma is an chronic airway disease with bronchial hypersensitivity due to inflammation and bronchial muscle contraction. (clinicaltrials.gov)
  • A method as described for testing the susceptibility of a person to asthma. (google.com)
  • Bronchial provocation testing - irritates your airways to check for asthma. (mainlinehealth.org)
  • 1995), Lung Function & Bronchial Provocation Tests For Intending Divers With A History Of Asthma, SPUMS, 25(4), 233-248. (scuba-doc.com)
  • Objective To determine the agents causing asthmatic reactions during specific inhalation challenges (SICs) in workers with cleaning-related asthma symptoms and to assess the pattern of bronchial responses in order to identify the mechanisms involved in cleaning-related asthma. (bmj.com)
  • Conclusions These data indicate that a substantial proportion of workers who experience asthma symptoms related to cleaning materials show a pattern of bronchial reaction consistent with sensitiser-induced occupational asthma. (bmj.com)
  • when we think of having breathing problems we tend to quickly dismiss it as asthma, when it could be being caused by something else, that's why your doctor ordered so many test. (healingwell.com)
  • Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma: effect of inhaled corticosteroids Cough variant asthma (CVA) is a cause of chronic cough and a precursor of typical asthma. (tripdatabase.com)
  • Bronchial asthma is characterized by occasional, reversible airway obstruction that, if not properly treated, can lead to permanent obstruction. (cun.es)
  • What are the symptoms of bronchial asthma? (cun.es)
  • How is bronchial asthma diagnosed? (cun.es)
  • For a correct diagnosis and treatment of bronchial asthma it is essential to have a multi-disciplinary team (pneumologists, allergists and sometimes otolaryngologists and gastroenterologists). (cun.es)
  • Spirometry and non-specific bronchial responsiveness should be measured, but carefully performed and validly analysed serial peak expiratory flow or forced expiratory volume in one second (FEV 1 ) measurements are more specific and confirm occupational asthma in about 82% of those still exposed to the causative agent. (cdc.gov)
  • Diagnosis of work-related asthma is in many cases a complex undertaking consisting of various diagnostic tests and procedures. (cdc.gov)
  • Tests appropriate for the diagnosis of occupational asthma and rhinitis include pulmonary function studies, bronchial provocation tests, chest roentgenograms, skin tests, and the radio allergosorbent test. (cdc.gov)
  • Lung function tests, also known as pulmonary function test is used for the diagnosis of lung disorders such as asthma, respiratory infections, chronic obstructive pulmonary disease (COPD), and others. (medgadget.com)
  • Rising prevalence of lung diseases such as asthma, COPD, and others, availability of lung function test devices, and increasing demand for lung function test are important factors accelerating the growth of the market. (medgadget.com)
  • America is the leading market for lung function tests owing to the rising prevalence of various types of allergies in the U.S. According to the American College of Allergy Asthma and Immunology, allergic asthma, food allergy, and eczema are the most common types of allergies in the U.S. It further stated that 1 in every 12 people is suffering from allergic rhinitis in the U.S. (medgadget.com)
  • In the first step of a study of the relation of nasal and oral breathing during moderate treadmill exercise to the onset of bronchoconstriction in young patients with perennial bronchial asthma, it was observed that most subjects spontaneously breathed with their mouths open when instructed to breathe "naturally. (buteykoclinic.com)
  • Limited access to exercise testing facilities means that the diagnosis of exercise induced asthma (EIA) is mainly based on self-reported respiratory symptoms. (bmj.com)
  • A patient with asthma was defined as one who has symptoms compatible with asthma and showed either a positive provocation testing or bronchodilator reversibility. (medsci.org)
  • A variety of clinical services are offered including pulmonary function testing and asthma education. (monashhealth.org)
  • skin prick testing most commonly used to assess allergy in asthma and hayfever sufferers, small number of food allergens available for assessment. (monashhealth.org)
  • The combination of many domestic and foreign studies led to the conclusion that more than 50% of patients with bronchial asthma also suffered from AR [ 8 , 9 ] and that the risk of patients with AR developing asthma is eight times greater than normal [ 10 ]. (alliedacademies.org)
  • Bronchial asthma occurs in a high percentage of children with allergic rhinitis. (healio.com)
  • Although the general clinical impression is that effective treatment of allergic rhinitis greatly assists in the management of bronchial asthma when the two conditions coexist, the value of antihistamine therapy in asthma treatment is not entirely clear and somewhat controversial. (healio.com)
  • In those children who have bronchial asthma, allergic rhinitis precedes the appearance of lower respiratory illness more often than not. (healio.com)
  • Bronchial hyperreactivity is the basic feature of bronchial asthma and it occurs more often in athletes than in general population, especially in swimmers and winter sports athletes [1, 2]. (termedia.pl)
  • There are a lot of tests you do, yet the most important in diagnosisng asthma is performing a forced vital capacity ( FVC ). (healthcentral.com)
  • If your doctor suspects you might have asthma, yet your initial PFT results are normal, he may have you undergo bronchial provocation (also called a challenge test). (healthcentral.com)
  • There really is no one single test that says, 'you have asthma. (healthcentral.com)
  • Although most asthma experts believe PFT testing, particularly the FEV1 results, aren the best indicator that you probably have asthma. (healthcentral.com)
  • AK was determined by means of the Asthma Knowledge Test (AKT). (aerzteblatt.de)
  • Background:In athletes with exercise-induced asthma, confirmation of the disease with an objective test is required as part of the Therapeutic Use Exemption (TUE) application. (aspergillus.org.uk)
  • Aim:To evaluate the use of diagnostic tests in newly referred athletes with possible exercise-induced asthma in a specialized outpatient clinic. (aspergillus.org.uk)
  • Conclusion: In more than eight out of ten athletes with exercise induced asthma, more than one test for AHR or reversibility was necessary as part of the diagnostic process. (aspergillus.org.uk)
  • This is a bronchial provocation challenge to determine the presence of asthma or hypersensitivity. (therespiratoryunit.org.uk)
  • Bronchial Hyperresponsiveness in Skiers: Field Test versus Methacholine Provocation? (lww.com)
  • Nonspecific bronchial hyperresponsiveness was diagnosed. (nih.gov)
  • Non-specific bronchial hyperresponsiveness (NSBH) is a known predictor of accelerated rate of decline in lung function in smokers. (bmj.com)
  • Non-specific bronchial hyperresponsiveness (NSBH) is a known risk factor for the respiratory symptoms and disease progression in chronic obstructive pulmonary disease (COPD). (bmj.com)
  • Bronchial hyperresponsiveness, airway inflammation, and airflow limitation in endurance athletes. (biomedsearch.com)
  • 2007). 'Bronchial Hyperresponsiveness in Women Cooks and Cleaners', Arhiv za higijenu rada i toksikologiju , 58(2), str. (srce.hr)
  • Karadžinska-Bislimovska J, Minov J, Risteska-Kuc S, Stoleski S, Mijakoski D. Bronchial Hyperresponsiveness in Women Cooks and Cleaners. (srce.hr)
  • J. Karadžinska-Bislimovska, J. Minov, S. Risteska-Kuc, S. Stoleski i D. Mijakoski, "Bronchial Hyperresponsiveness in Women Cooks and Cleaners", Arhiv za higijenu rada i toksikologiju , vol.58, br. (srce.hr)
  • The aim of this cross-sectional study was to assess the prevalence and characteristics of bronchial hyperresponsiveness (BHR) in 43 women cleaners (aged 26 to 57) and 37 women cooks (aged 29 to 55) and compare them with 45 controls (women office workers aged 27 to 58). (srce.hr)
  • Smoking cessation clearly improves respiratory symptoms and bronchial hyperresponsiveness, and prevents excessive decline in lung function in all three groups. (ersjournals.com)
  • Consequently, the primary aim of the present review is to provide an overview of the effects of smoking cessation on respiratory symptoms, lung function (FEV 1 and extent of longitudinal decline in FEV 1 ), bronchial hyperresponsiveness, and the pathological and inflammatory changes in the lungs of the above-mentioned groups. (ersjournals.com)
  • Finally, if the diagnosis remains unclear a follow-up with serial measurements of FEV 1 and non-specific bronchial hyperresponsiveness should detect those likely to develop permanent impairment from their occupational exposures. (cdc.gov)
  • Clinical assessment of bronchial hyperresponsiveness due to nonspecific and specific agents. (cdc.gov)
  • A variety of different bronchial provocation methods have been described to test for specific bronchial hyperresponsiveness. (cdc.gov)
  • Background The International Olympic Committee-Medical Commission (IOC-MC) accepts a number of bronchial provocation tests for the diagnosis of exercise-induced bronchoconstriction (EIB) in elite athletes, none of which have been studied in elite swimmers. (bmj.com)
  • With the suggestion of a different pathogenesis involved in the development of EIB in swimmers, there is a possibility that the recommended test for EIB in elite athletes, the eucapnic voluntary hyperpnoea (EVH) challenge, may be missing the diagnosis in elite swimmers. (bmj.com)
  • The EVH challenge, a well-established and standardised test for EIB in elite winter and summer land-based athletes, should thus be used for the diagnosis of EIB in elite swimmers, as recommended by the IOC-MC. (bmj.com)
  • Lung function tests can help in the diagnosis of respiratory (breathing) conditions, work out how severe a condition is, and help monitor the response to treatments. (mydr.com.au)
  • Diagnosis of some pulmonary diseases requires certain types of testing. (clevelandclinic.org)
  • If a restrictive pattern is present, full pulmonary function tests with diffusing capacity of the lung for carbon monoxide testing should be ordered to confirm restrictive lung disease and form a differential diagnosis. (aafp.org)
  • Physicians can use the following stepwise approach to not only interpret PFTs from their office or a pulmonary function laboratory, but also determine when to order further testing and how to use PFT results to formulate a differential diagnosis. (aafp.org)
  • Inova Pulmonary Diagnostic tests and treatments can help assess an individual's lung health, confirm a diagnosis, classify disease severity and progression, determine the best therapy, and evaluate a patient's response to prescribed therapy. (inova.org)
  • Respiratory tests for the diagnosis of obstructive lung disease and lung hyperreactivity. (sld.cu)
  • The uselfulness of exertion spirometry was evidenced for the diagnosis of obstructive pneumopathy and for the detection of bronchial hypereactivity, as well as the usefulness of nebulization with distilled water for this purpose. (sld.cu)
  • Spirometric testing supports the diagnosis of VCD in symptomatic individuals. (medscape.com)
  • A comparison of skin endpoint titration and skin-prick testing in the diagnosis of allergic rhinitis. (thefreelibrary.com)
  • Among the many methods of allergy diagnosis are intradermal testing (IDT) and skin-prick testing (SPT). (thefreelibrary.com)
  • Making an accurate diagnosis sometimes requires testing with different treatments. (cun.es)
  • Therefore, lung function test plays a vital role in the diagnosis of various respiratory diseases, and lung disorders. (medgadget.com)
  • Of the remainder: 12 (23.1%) were unfit, 14 (26.9%) had vocal cord dysfunction/sigh dyspnoea, 7 (13.5%) had a habit cough, and 11 (21.1%) had no abnormalities on clinical or laboratory testing, so were given no diagnosis. (bmj.com)
  • An objective diagnosis often requires multiple testing with bronchial provocations and lung function measurements. (aspergillus.org.uk)
  • Diagnosis is typically based on a combination of symptoms and a skin prick test or blood tests for allergen-specific IgE antibodies. (wikipedia.org)
  • Everyone can benefit from pulmonary diagnostic testing - from athletes and healthy individuals who want to know their lung function and exercise status to those preparing for thoracic (chest) surgery, and people living with allergies or a lung condition. (inova.org)
  • You must have an order from your physician, nurse practitioner or physician assistant, to undergo pulmonary diagnostic testing and treatments. (inova.org)
  • This test is diagnostic of restrictive lung disease, evaluation of resistence to airflow. (somc.org)
  • Using our advanced diagnostic testing, treatments and therapeutic rehabilitation services, our team works with you to get you back in action. (mainlinehealth.org)
  • Order or perform diagnostic tests such as skin pricks and intradermal, patch, or delayed hypersensitivity tests. (onetonline.org)
  • Interpret diagnostic test results to make appropriate differential diagnoses. (onetonline.org)
  • It will be necessary to perform several diagnostic tests, depending on the clinical history and physical examination. (cun.es)
  • It has also been reported that many patients with AR also exhibit characteristics of non-specific Bronchial Hyperreactivity (BHR) [ 2 ]. (alliedacademies.org)
  • Bronchoconstriction is a form of bronchial hyperreactivity which is defined as increased readiness of the bronchi to constrict in response to a variety of external factors. (termedia.pl)
  • Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. (ersjournals.com)
  • CONCLUSIONS: Non-responsiveness to indirect bronchial provocation tests following inhaled corticosteroids occurs weeks to months following the resolution of symptoms and lung function. (mendeley.com)
  • The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). (kjim.org)
  • Thus evaluation of airway responsiveness by both bronchial provocation tests and bronchodilator testing can be assessed reliably within a few hours in asthmatic patients. (unict.it)
  • We carried out a retrospective study of Korean adults who underwent skin prick testing, and, in some cases, spirometry and bronchial provocation tests in a secondary care hospital from April 2010 to February 2011. (medsci.org)
  • Therefore, this study evaluated the effect of a prior bronchial provocation test on the bronchodilator response to salbutamol after spontaneous recovery of the forced expiratory volume in one second (FEV1) in a group of asthmatic subjects. (unict.it)
  • Scope note: Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g. histamine, methacholine), or control solutions, folllowed by assessment of respiratory function. (loc.gov)
  • Different types of lung function tests may be recommended by your general practitioner (GP) , respiratory physician (specialist in conditions affecting the airways and lungs) or paediatrician (specialist in children's health), depending on your age and condition. (mydr.com.au)
  • Other tests available at respiratory departments in teaching hospitals include exercise testing, bronchial provocation tests (see below) and lung volume measurements. (mydr.com.au)
  • The new International Union Against Tuberculosis (IUAT) bronchial symptoms questionnaire was completed by 827 subjects participating in a prospective study of respiratory symptoms and lung function in aluminum smelter workers. (nih.gov)
  • Our team of Licensed Respiratory Care Practitioners are highly trained specialists in exercise and lung testing protocols. (ucdavis.edu)
  • Office-based pulmonary function testing, also known as spirometry, is a powerful tool for primary care physicians to diagnose and manage respiratory problems. (aafp.org)
  • Pulmonary function tests (PFTs) are useful for diagnosing the cause of unexplained respiratory symptoms and monitoring patients with known respiratory disease. (aafp.org)
  • Both BHR and bronchial obstruction at rest with subsequent expiratory flow limitation during exercise may promote respiratory symptoms during exercise in athletes. (biomedsearch.com)
  • This testing provides metabolic measurements using indirect calorimetry for determination of oxygen consumption, carbon dioxide production, respiratory quotient and resting energy expenditure as an aid to patient nutritional assessment and management, assessment of weaning success and outcome. (somc.org)
  • The test is done using the ergometer (exercise bike) and we monitor the respiratory and cardiac data while the patient exercises on the bike. (somc.org)
  • Functional respiratory tests were found to be pathologic in most of the patients studied, regarding smoking habit. (sld.cu)
  • A pulmonary function test determines the origin and extent of respiratory disease and response to therapy. (princetonhcs.org)
  • Such patients may benefit from a high altitude simulation test (HAST), which can be performed in most respiratory laboratories, to determine the required oxygen flow during flight. (racgp.org.au)
  • Therefore, for patients in whom the risks appear significant or where there is doubt, a specialist respiratory opinion is appropriate and further testing may be performed as deemed necessary. (racgp.org.au)
  • 6 Limited access to specific exercise testing facilities means that in general clinical practice, most diagnoses are based on exercise related respiratory symptoms reported by the child or parents. (bmj.com)
  • When I was 14, after performing a pulmonary function test (PFT), I had a hundred questions for the respiratory therapist who performed the test. (healthcentral.com)
  • Design 33 elite swimmers were evaluated on separate days for the presence of EIB using 3 different bronchial provocation challenge tests: an 8 minute field swim challenge, a 6 minute laboratory EVH challenge, and an 8 minute laboratory cycle challenge. (bmj.com)
  • 1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. (thefreedictionary.com)
  • To study the clinical significance of cockroach allergen in adult asthmatics in Japan, we performed intradermal skin test to four commercial base cockroach extracts. (nii.ac.jp)
  • After approximately 5 minutes, mucosal swelling develops, leading to reduced nasal airflow.5 A "priming effect" on the bronchial and nasal mucosa occurs with repeated exposure to an allergen during a "season. (healio.com)
  • Your doctor may also order a blood test called arterial blood gas as an additional test. (getasthmahelp.org)
  • The Pulmonary Function Lab provides pulmonary function testing and diagnostics along with arterial blood gas analysis. (clevelandclinic.org)
  • The bronchial provocation test (BPT) is used to identify AHR, and can be either direct or indirect depending on the mechanism by which the stimulus mediates bronchoconstriction. (kjim.org)
  • We have studied the reproducibility of a bronchial leukotriene (LT) provocation test in asthmatics, and the effect of prior treatment with an oral leukotriene D4/E4 antagonist (SR 2640) on LTD4-induced bronchoconstriction in nine asthmatics in a double-blind placebo-controlled randomized cross-over trial. (unboundmedicine.com)
  • Skin prick test results were positive to birch pollen and fresh/dry chicory, and negative for inulin. (nih.gov)
  • The evaluation of all subjects included a questionnaire, skin prick tests to common aeroallergens, spirometry, and histamine challenge (PC20≤8 mg mL-1). (srce.hr)
  • The evaluation included a questionnaire, skin prick tests to workplace and common inhalant allergens, spirometry, and histamine challenge test. (srce.hr)
  • Among the factors that must be considered in evaluating the appropriateness of any given test are its safety (minimal risk of anaphylaxis), sensitivity, specificity positive and negative predictive values, reproducibility correlation with symptoms, and ease of administration The allergy testing modalities that are available to the clinician include in vitro testing (IVT), skin-prick testing (SPT), intradermal testing (IDT) (including skin endpoint titration [SET]), and nasal provocation testing (NPT). (thefreelibrary.com)
  • Skin prick testing or specific immunoglobulin E assays are useful to document allergy to high molecular weight allergens. (cdc.gov)
  • Skin prick allergy tests assess the presence and severity of allergy to specific allergens. (therespiratoryunit.org.uk)
  • All undertook serial allergy tests and specific bronchial provocation testing. (ilo.org)
  • The Pulmonary Function Testing Laboratory is well equipped with spirometry, plethsymography, diffusion capacity measurements, bronchial provocation testing, allergy testing. (sun.ac.za)
  • Diving evaluations for asthmatic patients have focused on a thorough patient history, spirometry, allergy testing, and bronchial challenges. (springer.com)
  • We also offer a comprehensive Skin Allergy Testing service to identify substances responsible for a variety of Allergic conditions. (therespiratoryunit.org.uk)
  • A provocation test with dry chicory induced acute rhinoconjunctivitis and an immediate asthmatic response with no further clinical symptoms. (nih.gov)
  • This testing provides an objective assessment of exercise and related symptoms. (somc.org)
  • Thereafter surveillance should be performed for the early identification of symptoms, including occupational rhinitis, with additional functional and immunological tests where appropriate. (bmj.com)
  • This is open to error since the correlation between exercise related symptoms and subsequent exercise testing has been shown to be poor. (bmj.com)
  • However, several authors have shown poor correlation between self-reported exercise symptoms and the results of specific exercise testing, 7- 9 with high frequencies of false positive and false negative results. (bmj.com)
  • diffusing capacity recommended when testing for disease such as chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. (monashhealth.org)
  • A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. (springer.com)
  • Some diving societies recommend that an asthmatic patient should successfully pass a bronchial provocation challenge. (springer.com)
  • and (4) bronchial inflammation using induced sputum and nitric oxide (NO) exhalation. (biomedsearch.com)
  • The same technique of dry powder inhalation can be used to test for the susceptibility of a person to rhinitus, to induce sputum and promote mucociliary clearance. (google.com)
  • Secondary endpoints included the difference in FENO, PD20FEV1-LTD4, PD20FEV1-MCh, pre-test FEV1, ACT score, AQLQ symptom score, week 4 PEFmax and PEFmin as compared with week 1, gradual decrease in the use of salbutamol and the days without using salbutamol. (clinicaltrials.gov)
  • Mean pre-test FEV1 (mean ± SD) was 95.5 ± 14% predicted. (biomedcentral.com)
  • This test is used as a substitute for FEV1 in adults who have significant air trapping and who get 'light headed' while trying to forcibly do spirometry. (healthcentral.com)
  • The prevalence of sensitisation to allergens and of bronchial hyperresponsivenss (BHR) did not differ significantly between the groups. (srce.hr)
  • Main outcome measurements Change in forced expiratory volume in 1 second (FEV 1 ) pre and post test protocol. (bmj.com)
  • Some of the more common measurements done by spirometry include a test called forced vital capacity. (getasthmahelp.org)
  • Acoustic rhinometric measurements of the nasal responses revealed that 34 patients tested positive and 28 negative. (thefreelibrary.com)
  • A test that measures a simple, accessible biomarker that can detect inflammation of airways. (somc.org)
  • Conclusions These results suggest that the EVH challenge is a highly sensitive challenge for identifying EIB in elite swimmers, in contrast to the laboratory and field-based exercise challenge tests, which significantly underdiagnose the condition. (bmj.com)
  • Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. (biomedcentral.com)
  • Exercise challenge test - where spirometry is done before and after exercising (e.g. using an exercise bike, walking or running on a treadmill or climbing stairs), to see if exercise triggers airway narrowing. (mydr.com.au)
  • Bronchial challenge with both agonists failed to alter significantly the airway response to salbutamol, with the deltaFEV1% init mean value (range) being 16.9% (9.0-31.9) and 17.5% (11.6-31.2) on the sham and histamine/methacholine challenge day respectively. (unict.it)
  • Bronchial reactivity (BR) was measured in 809 subjects by methacholine challenge using a rapid method. (nih.gov)
  • bronchial challenge ( inhalational challenge ) bronchial challenge test . (thefreedictionary.com)
  • It is clinically used to measure response of bronchial reactivity, either by the drugs Aridol or Methacholine and/or Exercise Induced Challenge. (somc.org)
  • Standardization of bronchial inhalation challenge procedures. (springer.com)
  • ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. (springer.com)
  • Guidelines for methacholine and exercise challenge testing-1999. (springer.com)
  • Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close monitoring of the patient during the challenge and for at least 6 h afterwards. (ersjournals.com)
  • In this context, specific inhalation challenge (SIC) testing is the controlled exposure of a patient, under laboratory conditions, to an agent encountered in their workplace. (ersjournals.com)
  • Challenge phase: 1, 5 and 10% w/w test material in petroleum jelly. (europa.eu)
  • There is a lack of quantitative exposure assessment during the challenge tests. (bmj.com)
  • Increased neutrophil chemotactic activity was found in serum tested from 5 to 30 min after a positive ragweed-inhalation challenge, but not after negative ragweed challenge. (annals.org)
  • Specific inhalational challenge tests come closest to a gold standard test, but lack standardisation, availability and sensitivity. (cdc.gov)
  • Badier M1, Guillot C, Delpierre S et al (2000) Value of bronchial challenge in scuba diving candidates. (springer.com)
  • Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity. (koreamed.org)
  • Exercise testing may be used to assess children older than 8 years who complain of shortness of breath, often associated with exercise. (mydr.com.au)
  • Walking test used to assess physical fitness and or the need for oxygen during walking. (ucdavis.edu)
  • This test simulates the conditions of air travel to assess whether in-flight oxygen is required. (therespiratoryunit.org.uk)
  • This is a standardised exercise test to assess the oxygen levels in the blood during exercise. (therespiratoryunit.org.uk)
  • Check with your physician or the pulmonary function testing site about specific instructions for your breathing medications prior to the testing. (getasthmahelp.org)
  • Pulmonary function testing has a rich and diverse history. (springer.com)
  • Within the confines of the present book, this chapter will focus on selected highlights relevant to clinical pulmonary function testing, through which we hope that the reader can gain a deeper understanding of the different tests as each is done today. (springer.com)
  • Purpose: Forced expiratory flow between 25% and 75% (FEF 25%-75%) is known to sensitively reflect bronchial obstruction. (koreamed.org)
  • It was shown that the degree of bronchodilatation achieved after salbutamol 200 microg is not affected by prior bronchoprovocation testing when enough time is allowed for the airways to recover spontaneously to baseline forced expiratory volume in one second. (unict.it)
  • We have therefore chosen to organize this chapter by test, as one would see on a typical PFT result sheet: spirometry, lung volumes, diffusing capacity, and bronchoprovocation. (springer.com)
  • The exercise bronchoprovocation test: standardization of procedures and evaluation of response. (springer.com)
  • Wall, M 1989, ' Assessment of changes in 1‐second forced expiratory volume in bronchial provocation testing ', Pediatric pulmonology , vol. 6, no. 2, pp. 71-73. (elsevier.com)
  • Lung function tests, also called pulmonary function tests or breathing tests, are tests that can be done to find out how well your lungs and airways are working. (mydr.com.au)
  • Exercise tests can show whether or how much your breathing problems are impacting on your daily life. (mydr.com.au)
  • Under the direction of medical director Nicolas Stollenwerk M.D. , the pulmonary function and exercise testing lab at UC Davis Medical Center offers state of the art lung function and exercise testing. (ucdavis.edu)
  • Our pulmonary function and exercise lab acts as the testing lab for many UCDHS sponsored clinical research studies for new medications and treatments for lung disease and other chronic disorders. (ucdavis.edu)
  • BACKGROUND: Whereas a high prevalence of bronchial abnormalities has been reported in endurance athletes, its underlying mechanisms and consequences during exercise are still unclear. (biomedsearch.com)
  • The medical examiner should perform an exercise test such as the 18 in (43 cm) step test for three minutes, or running outside (not a bicycle ergometer) to increase the heart rate to 80% (210-age). (scuba-doc.com)
  • Following a careful history and physical examination, children performed pulmonary function tests before, then 5 and 15 minutes after a standardised treadmill exercise test. (bmj.com)
  • The condition is defined and quantified on the basis of changes in lung function measured before and after a standardised exercise test. (bmj.com)
  • Studies with experimental bronchospasm (histamine provocation test) for determination of the efficacy of an antihistaminic]. (curehunter.com)
  • The second method uses the same doubling dosage regimen of histamine and methacholine and generates the aerosol using a Wright's nebulizer primed with 5 milliliter test solution and an oxygen flow rate of 7 liter/minute. (cdc.gov)
  • Objective4To investigate whether leukotriene D4 bronchial provocation test (LTD4-BPT) could be an indicator of actual therapeutic outcome of LTRA. (clinicaltrials.gov)
  • The reproducibility of the bronchial leukotriene provocation test was high. (unboundmedicine.com)
  • [ 2 ] This document provides examples of the most common technical problems associated with spirometry testing. (medscape.com)
  • We reviewed the use of bronchial provocation tests that use stimuli that act indirectly for monitoring the benefits of inhaled corticosteroids. (mendeley.com)
  • Lung function tests can be done in adults and in children older than about 7 years. (mydr.com.au)
  • What are the different types of lung function tests? (mydr.com.au)
  • Spirometry is a test of lung function that measures the amount of air breathed in and out. (mydr.com.au)
  • Pulmonary function tests (PFTs) are a series of different breathing tests led by a trained pulmonary function technologist, usually done at a hospital or clinic. (getasthmahelp.org)
  • There are global standards and guidelines that help make sure that everyone does and interprets pulmonary function tests in the same way. (getasthmahelp.org)
  • To learn about your lung health, your doctor may want you to have several pulmonary function tests done including spirometry , lung volumes , diffusing capacity , and airway resistance. (getasthmahelp.org)
  • Pulmonary function tests are specialized breathing tests performed to "fingerprint" the breathing cycle. (clevelandclinic.org)
  • These tests help to measure how well the lungs function in different respects. (clevelandclinic.org)
  • Pulmonary function tests are a group of tests that measure how well the lungs take in and release air and how well they move gases such as oxygen from the atmosphere into the body's circulation. (omicsonline.org)
  • Then, the patients had undergone thoracic high-resolution computed tomography (HRCT) and pulmonary function tests (PFT). (thefreelibrary.com)
  • The Pulmonary Function Laboratory brings together state-of-the-art testing equipment and the largest team of pediatric pulmonary specialists of any hospital in California to confidently diagnose and treat infants, kids and teens with any lung or breathing condition. (stanfordchildrens.org)
  • After stopping work for a period of 10 days, workers in areas with a high concentration of TDI showed marked improvement in pulmonary function tests (PFTs). (nap.edu)
  • Suggested methods of prevention include recognition of sensitizers in the workplace, possible preemployment screening to determine atopic status, exposure monitoring, evaluation of pre and post shift pulmonary function tests to determine early sensitization, and relocation of the sensitized worker to minimize exposure. (cdc.gov)
  • The healthcare provider may recommend lung function tests to diagnose the suspected lung disease, plan the treatment, and decide whether to continue the ongoing treatment or change it and even to stop the treatment, if required. (medgadget.com)
  • The global lung function tests market is expected to grow at a CAGR of 5.7% during the forecast period. (medgadget.com)
  • The global lung function tests market is segmented on the basis of type, indication, devices, and end user. (medgadget.com)
  • Europe is the second largest market for lung function tests. (medgadget.com)
  • We can also assist with training of general practice staff who perform basic lung function testing. (monashhealth.org)
  • gas diffusion tests. (mydr.com.au)
  • This test measures the resistance to diffusion of gasses across the alveolocapillary membrane. (somc.org)
  • Lung diffusion testing - measures how well your lungs can exchange gases. (mainlinehealth.org)
  • On the basis of the type, the market is segmented into spirometry, gas diffusion test, body plethysmograph, bronchial provocation test, and others. (medgadget.com)
  • Spirometry reversibility testing - uses information from your spirometry test results to calculate how effective treatment for your illness might be. (mainlinehealth.org)
  • We performed nasal provocation testing on 62 patients to establish an unbiased screening criterion for study entry. (thefreelibrary.com)
  • All patients were subsequently tested by SET and SPT. (thefreelibrary.com)
  • The results of our study suggest that the information obtained by the SET method of IDT is comparable to that obtained by SPT in terms of sensitivity, specificity, and overall performance and that both SET and SPT correlate well with nasal provocation testing for ragweed. (thefreelibrary.com)
  • An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old. (edu.au)