Bronchial Provocation Tests: Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Nasal Provocation Tests: Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Metallurgy: The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)Forced Expiratory Volume: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.Occupational Diseases: Diseases caused by factors involved in one's employment.Ergonovine: An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.Bronchoconstrictor Agents: Agents causing the narrowing of the lumen of a bronchus or bronchiole.Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Resins, Plant: Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Bronchoconstriction: Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Spirometry: Measurement of volume of air inhaled or exhaled by the lung.Saline Solution, Hypertonic: Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).Angina Pectoris, Variant: A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.Mannitol: A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.Vital Capacity: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Immunologic Tests: Immunologic techniques involved in diagnosis.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Rhinitis, Allergic, Seasonal: Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.Vibration: A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Conjunctivitis, Allergic: Conjunctivitis due to hypersensitivity to various allergens.Oxytocics: Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)Alveolitis, Extrinsic Allergic: A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.Rhinitis, Allergic, Perennial: Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Dermatophagoides pteronyssinus: Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.Cromolyn Sodium: A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.Skin Temperature: The TEMPERATURE at the outer surface of the body.Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.Pollen: The fertilizing element of plants that contains the male GAMETOPHYTES.Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Rhinitis: Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Lung Diseases: Pathological processes involving any part of the LUNG.Respiratory Tract DiseasesPrivacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Science: The study of natural phenomena by observation, measurement, and experimentation.Sports Medicine: The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.

Respiratory symptoms among glass bottle workers--cough and airways irritancy syndrome? (1/1269)

Glass bottle workers have been shown to experience an excess of respiratory symptoms. This work describes in detail the symptoms reported by a cohort of 69 symptomatic glass bottle workers. Symptoms, employment history and clinical investigations including radiology, spirometry and serial peak expiratory flow rate records were retrospectively analyzed from clinical records. The results showed a consistent syndrome of work-related eye, nose and throat irritation followed after a variable period by shortness of breath. The latent interval between starting work and first developing symptoms was typically 4 years (median = 4 yrs; range = 0-28). The interval preceding the development of dysponea was longer and much more variable (median = 16 yrs; range = 3-40). Spirometry was not markedly abnormal in the group but 57% of workers had abnormal serial peak expiratory flow rate charts. Workers in this industry experience upper and lower respiratory tract symptoms consistent with irritant exposure. The long-term functional significance of these symptoms should be formally investigated.  (+info)

Dose-response slope of forced oscillation and forced expiratory parameters in bronchial challenge testing. (2/1269)

In population studies, the provocative dose (PD) of bronchoconstrictor causing a significant decrement in lung function cannot be calculated for most subjects. Dose-response curves for carbachol were examined to determine whether this relationship can be summarized by means of a continuous index likely to be calculable for all subjects, namely the two-point dose response slope (DRS) of mean resistance (Rm) and resistance at 10 Hz (R10) measured by the forced oscillation technique (FOT). Five doses of carbachol (320 microg each) were inhaled by 71 patients referred for investigation of asthma (n=16), chronic cough (n=15), nasal polyposis (n=8), chronic rhinitis (n=8), dyspnoea (n=8), urticaria (n=5), post-anaphylactic shock (n=4) and miscellaneous conditions (n=7). FOT resistance and forced expiratory volume in one second (FEV1) were measured in close succession. The PD of carbachol leading to a fall in FEV1 > or = 20% (PD20) or a rise in Rm or R10 > or = 47% (PD47,Rm and PD47,R10) were calculated by interpolation. DRS for FEV1 (DRSFEV1), Rm (DRSRm) and R10 (DRSR10) were obtained as the percentage change at last dose divided by the total dose of carbachol. The sensitivity (Se) and specificity (Sp) of DRSRm, DRS10 delta%Rm and delta%R10 in detecting spirometric bronchial hyperresponsiveness (BHR, fall in FEV1 > or = 20%) were assessed by receiver operating characteristic (ROC) curves. There were 23 (32%) "spirometric" reactors. PD20 correlated strongly with DRSFEV1 (r=-0.962; p=0.0001); PD47,Rm correlated significantly with DRSRm (r=-0.648; p=0.0001) and PD47,R10 with DRSR10 (r=-0.552; p=0.0001). DRSFEV1 correlated significantly with both DRSRm (r=0.700; p=0.0001) and DRSR10 (r=0.784; p=0.0001). The Se and Sp of the various FOT indices to correctly detect spirometric BHR were as follows: DRSRm: Se=91.3%, Sp=81.2%; DRSR10: Se=91.3%, Sp=95.8%; delta%Rm: Se=86.9%, Sp=52.1%; and delta%R10: Se=91.3%, Sp=58.3%. Dose-response slopes of indices of forced oscillation technique resistance, especially the dose-response slope of resistance at 10Hz are proposed as simple quantitative indices of bronchial responsiveness which can be calculated for all subjects and that may be useful in occupational epidemiology.  (+info)

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (3/1269)

Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper respiratory tract infection, were randomly selected from a large-scale epidemiological survey in Central Norway. All were investigated with flow-volume spirometry, methacholine provocation test, allergy testing and measurement of nasal and exhaled NO concentration in the nonpollen season. Eighteen rhinitic subjects completed an identical follow-up investigation during the following pollen season. Exhaled NO was significantly elevated in allergic rhinitis in the nonpollen season, especially in perennially sensitized subjects, as compared with controls (p=0.01), and increased further in the pollen season (p=0.04), mainly due to a two-fold increase in those with seasonal sensitization. Nasal NO was not significantly different from controls in the nonpollen season and did not increase significantly in the pollen season. Exhaled NO was increased in hyperresponsive subjects, and decreased significantly after methacholine-induced bronchoconstriction, suggesting that NO production occurs in the peripheral airways. In allergic rhinitis, an increase in exhaled nitric oxide on allergen exposure, particularly in hyperresponsive subjects, may be suggestive of airway inflammation and an increased risk for developing asthma.  (+info)

Bradykinin-induced bronchospasm in the rat in vivo: a role for nitric oxide modulation. (4/1269)

Bradykinin has an important role in asthma pathogenesis, but its site of action is unclear. It was previously reported by the authors that bradykinin causes a dose-dependent reduction in dynamic compliance but little change in total lung resistance. This suggested that bradykinin may have a preferential effect in the distant lung. The purpose of the current investigation was to better characterize the effects of bradykinin on pulmonary resistance in rodents and explore the role of nitric oxide release in modulating the effect of bradykinin. Airway constriction was induced in the rats by aerosol administration of bradykinin with or without treatments with the inhaled bradykinin-2 receptor antagonist, Hoe 140 or the nitric oxide synthase inhibitors N(G)-nitro-L-arginine methylester or N(G)-monomethyl-L-arginine. Total lung resistance was partitioned into tissue and airway resistance by using the alveolar capsule method. Bradykinin induced a significant increase in both resistances. Hoe 140 abolished the response to bradykinin. The nitric oxide synthase inhibitors enhanced the bronchoconstricting response. In conclusion, the bradykinin response in the rats was not only localized to conducting airways but also involved a relatively selective tissue reaction. Bradykinin-induced bronchospasm in the rat is solely due to activation of bradykinin-2 receptor. Further, it was shown that nitric oxide significantly modulates the bronchospasm caused by bradykinin, suggesting that nitric oxide is an important modulator of airways responsiveness to bradykinin.  (+info)

Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis. (5/1269)

BACKGROUND: Inhaled corticosteroids are the most efficacious anti-inflammatory drugs in asthma. International guidelines also advocate the early introduction of inhaled corticosteroids in corticosteroid naive patients. A study was undertaken to assess the effects of inhaled corticosteroids on bronchial hyperresponsiveness in patients with corticosteroid naive asthma by conventional meta-analysis. METHODS: A Medline search of papers published between January 1966 and June 1998 was performed and 11 papers were selected in which the patients had no history of treatment with inhaled or oral corticosteroids. Bronchial responsiveness to bronchoconstricting agents was considered as the main outcome parameter. Doubling doses (DD) of histamine or methacholine were calculated. RESULTS: The total effect size of inhaled corticosteroids (average daily dose 1000 microg) versus placebo in the 11 studies was +1.16 DD (95% confidence interval (CI) +0.76 to +1.57). When only the eight short term studies (2-8 weeks) were analysed the effect size of the bronchoconstricting agent was +0.91 DD (95% CI +0.65 to +1.16). No relationship was found between the dose of inhaled corticosteroid used and the effect on bronchial responsiveness. CONCLUSION: This meta-analysis in patients with corticosteroid naive asthma indicates that, on average, high doses of inhaled corticosteroids decrease bronchial hyperresponsiveness in 2-8 weeks. It remains unclear whether there is a dose-response relationship between inhaled corticosteroids and effect on bronchial hyperresponsiveness.  (+info)

Update on the "Dutch hypothesis" for chronic respiratory disease. (6/1269)

BACKGROUND: Many patients with chronic obstructive lung disease show increased airways responsiveness to histamine. We investigated the hypothesis that increased airways responsiveness predicts the development and remission of chronic respiratory symptoms. METHODS: We used data from 24-year follow-up (1965-90) of 2684 participants in a cohort study in Vlagtwedde and Vlaardingen, Netherlands. Increased airways responsiveness was defined as a PC10 value (concentration of histamine for which challenge led to a 10% fall in forced expiratory volume in 1 s) of less than 8 mg/ml. Information on respiratory symptoms was collected by means of a standard questionnaire every 3 years. Logistic regression was used to control for age, area of residence, cigarette smoking status, and sex. FINDINGS: Participants with increased airways responsiveness (1281 observations) were more likely than those without increased airways responsiveness (5801 observations) to develop the following symptoms during any 3-year follow-up interval: chronic cough (odds ratio 1.9 [95% CI 1.2-2.9]), chronic phlegm (2.0 [1.3-3.0]), dyspnoea (2.3[1.5-3.5]), asthmatic attacks (3.7[2.2-6.1]), and persistent wheeze (2.7[1.7-4.4]). The estimate of the odds ratio for the development of any of the six symptoms was 1.7 (1.2-2.3). Participants with increased airways responsiveness were less likely than those without this characteristic to show remission of these respiratory symptoms. The estimate of the odds ratio for the remission of any of the six symptoms was 0.42 (0.28-0.61). INTERPRETATION: These prospective analyses show that increased airways responsiveness is positively associated with the development of chronic respiratory symptoms and negatively associated with the remission of these symptoms in adults.  (+info)

Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma. (7/1269)

BACKGROUND: It has been reported that pranlukast reduces the antigen induced immediate and late phase asthmatic responses, airway hyperreactivity to acetylcholine, and pulmonary eosinophil accumulation in guinea pigs. A study was undertaken to test the hypothesis that pranlukast may reduce the number of inflammatory cells in the bronchial mucosa of patients with asthma. METHODS: A double blind, placebo controlled study was performed in 17 mild to moderate asthmatic subjects to examine changes in inflammatory cell infiltration in response to pranlukast (225 mg orally twice per day for four weeks). Comparisons of the mean daily beta 2 agonist use, symptom score, FEV1 percentage predicted, and airway methacholine responsiveness were made before and after treatment. Using fibreoptic bronchoscopy, bronchial biopsy specimens were obtained before and after treatment with either pranlukast (n = 10) or placebo (n = 7). Immunohistology was performed using monoclonal antibodies for CD3, CD4, CD8, CD68, NP57, AA1, EG1, EG2, gamma GTP and CD19. RESULTS: When the pranlukast and placebo treated groups were compared there were decreases in beta 2 agonist use, symptom score, and airway methacholine responsiveness after pranlukast but no increase in FEV1 was seen. The clinical response in patients treated with pranlukast was accompanied by a reduction in CD3 (median difference -37, 95% confidence interval (CI) -69 to -1; p < 0.05), CD4 (median difference -28, 95% CI -49 to -8; p < 0.01), AA1 (median difference -15, 95% CI -26 to 0; p < 0.05) and EG2 positive cells (95% CI -35 to 0; p < 0.05), but not in EG1 positive eosinophils, gamma GTP positive cells, and CD19 positive plasma cells. CONCLUSIONS: These results support the view that pranlukast may act by inhibition of bronchial inflammation in patients with asthma.  (+info)

Clearance in small ciliated airways in allergic asthmatics after bronchial allergen provocation. (8/1269)

BACKGROUND: Asthma tends to affect mucociliary clearance, as assessed from measurements in large airways. However, there is no knowledge about clearance in the smallest airways of the tracheobronchial region in acute exacerbation of asthma. OBJECTIVE: The aim of the study was to investigate clearance from the bronchiolar region in patients with allergic asthma in a situation resembling a mild acute exacerbation of the disease. We also aimed to compare clearance data with corresponding data found for healthy subjects and asthmatics on therapy. METHODS: Tracheobronchial clearance was studied twice in 9 patients with mild asthma of the allergic type after inhalation of 6 microm (aerodynamic diameter) monodisperse Teflon particles labelled with 111In. At one exposure, inhalation was performed 4 h after bronchial provocation with an allergen the patients were allergic to. The second exposure was a control measurement. The particles were inhaled at an extremely slow flow, 0.05 liter/s, which gives deposition mainly in the small ciliated airways (bronchioles). Lung retention was measured at 0, 24, 48 and 72 h. RESULTS: All patients demonstrated an early asthmatic reaction of varying degree after bronchial provocation. There was significant clearance of radioaerosol in each 24-hour period for both exposures, with the possible exception of the period between 24 and 48 h for the provocation exposure, with similar fractions of retained particles at all points of time. The retained fractions were significantly larger compared to a group of healthy subjects and asthmatics on regular treatment with anti-inflammatory drugs. CONCLUSIONS: Our results indicate that in allergic asthmatics a bronchial allergen provocation with an early asthmatic reaction does not significantly influence overall clearance from the bronchiolar region. However, in the present group of patients, retention in small ciliated airways was significantly higher compared to healthy subjects and asthmatics on regular treatment.  (+info)

The incidence of asthma is increasing at an alarming rate. While the current available therapies are effective, there are associated side effects and they fail to adequately control symptoms in all patient subsets. In the search to understand disease pathogenesis and find effective therapies hypotheses are often tested in animal models before progressing into clinical studies. However, current dogma is that animal model data is often not predictive of clinical outcome. One possible reason for this is the end points measured such as antigen-challenge induced late asthmatic response (LAR) is often used in early clinical development, but seldom in animal model systems. As the mouse is typically selected as preferred species for pre-clinical models, we wanted to characterise and probe the validity of a murine model exhibiting an allergen induced LAR. C57BL/6 mice were sensitised with antigen and subsequently topically challenged with the same antigen. The role of AlumTM adjuvant, glucocorticoid, long acting
Specific Challenges to Data Collection Data collection poses specific challenges, including accessibility, trust, and user motivation. The following sections discuss how these issues affected our design. Challenges of Accessibility Advocates … - Selection from Beautiful Data [Book]
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The Respiratory Laboratory Scientist will explain and coach you through the testing process.. Test 1- Spirometry, Pre and Post bronchodilator:. This involves you blowing into a machine to see how much air you can blow out, how fast you can blow it out and whether or not it is better after administering a bronchodilator like Ventolin.. Test 2- Gas Diffusion (CO Uptake):. This test is used to determine the health of your lung tissue. It investigates how effectively oxygen is able to pass across the lung membrane and into the blood stream. This test involves you breathing into a machine and holding your breath.. Test 3- Bronchial Provocation Tests:. This test is performed to diagnose whether or not you have asthma. It simply involves you inhaling a spray or fine sugar powder at low, controlled doses to test the sensitivity of your airways.. Test 4- Exercise test for oxygen supplementation:. This is also known as a 6 Minute Walk Test and your doctor may wish for you to have one in order to see how ...
Concentration of methacholine (mg/ml) at which participants forced expired volume in 1 sec (FEV1) is reduced by 20% (the provocation concentration of methacholine causing a 20% fall in FEV1-PC20).. To measure if there is a significant difference in PC20 recorded at baseline to that recorded following 8 weeks treatment with omeprazole and ranitidine ...
Our study made a preliminary demonstration that the finding of obstruction based on the FEV1/FVC in the setting of a normal FEV1 (defined in this study as greater than 90% of predicted) does not consistently represent a normal physiologic variant. Nearly 28% of tested patients met criteria for AHR by either BD response or bronchoprovocation testing, irrespective of the presence or absence of symptoms. While there were no significant differences in AHR for those patients with an FEV1 , 100% of predicted versus ≥ 100% of predicted, the overall trend demonstrated a decreased frequency of AHR for an FEV1 ≥ 100% of predicted, as 80% of patients with evidence of AHR had an FEV1 , 100%. This becomes important in correlating the clinical suspicion for underlying disease with the indication (screening vs symptomatic) for PFT. Conversely, even in the presence of active pulmonary symptoms or established diagnoses, nearly 75% of patients tested did not demonstrate a significant BD response. This might ...
Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble interleukin-2 receptor, and interleukin-6 in asthmatic children ...
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways). Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Health Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. Bronchial hyperresponsiveness has been associated with gas cooking among subjects ...
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways).. Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold.. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Heart Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. ...
[Studies with experimental bronchospasm (histamine provocation test) for determination of the efficacy of an antihistaminic]. - H M Beumer
This is a Phase 3 study to determine the sensitivity and specificity of the Aridol bronchial challenge test to detect bronchial hyperresponsiveness in patients with suspected asthma. Patients with suspected asthma of either gender, aged between 6 and 50 years, with only mildly impaired lung function (FEV1 ,70%) are to be tested with three different bronchial hyperresponsiveness challenges (Aridol, exercise and methacholine), and the results compared. A clinical diagnosis will also be made at the end of the study ...
Asthma is a heterogeneous disease and clinical phenotypes are highly variable. This is exemplified in the variability of patients responses to medications such as beclomethasone. It is a critical clinical question whether a particular therapy will be effective in an individual child with symptoms of asthma. At the moment, there is a lack of diagnostic tools to assess this individual responsiveness. Beclomethasone is an inhaled corticosteroid (ICS) used as controller therapy in children with asthma, providing protection against bronchial hyperresponsiveness (BHR) and exercise induced bronchoconstriction (EIB). A single dose of an ICS can have a significant effect on BHR measured by a bronchial provocation test (BPT). This rapid response shows variability similar to the variable responsiveness to long term treatment. We hypothesized that the effect of a single dose of beclomethasone on a BPT (a mannitol challenge) could predict the effect of longterm therapy with beclomethasone on BHR ...
Dr. Anand responded: Methacholine test. The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut.
Walsh SL, Wells AU, Desai SR, Poletti V, Piciucchi S, Dubini A, Nunes H, Valeyre D, Brillet PY, Kambouchner M, Morais A, Pereira JM, Moura CS, Grutters JC, van den Heuvel DA, van Es HW, van Oosterhout MF, Seldenrijk CA, Bendstrup E, Rasmussen F, Madsen LB, Gooptu B, Pomplun S, Taniguchi H, Fukuoka J, Johkoh T, Nicholson AG, Sayer C, Edmunds L, Jacob J, Kokosi MA, Myers JL, Flaherty KR, Hansell DM, Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study., Lancet respiratory, 2016;:557-565,10.1016/S2213-2600(16)30033-9 ...
Smiths Medical Asthma Patient Testing Kit (Methacholine Bronchoprovocation) is a convenient, all-inclusive procedural kit for the assessment of the respiratory
TY - JOUR. T1 - Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness. AU - Allen, Marcus. AU - Graham, P.. AU - Morris, G.. PY - 1996/3/1. Y1 - 1996/3/1. M3 - Article. VL - 45. SP - 118. EP - 122. JO - Inflammation Research. JF - Inflammation Research. SN - 1023-3830. IS - 3. ER - ...
Vandenplas O, Suojalehto H, Aasen T, Baur X, Burge PS, de Blay F, Fishwick D, Hoyle J, Maestrelli P, Muñoz X, Moscato G, Sastre J, Sigsgaard T, Suuronen K, Walusiak-Skorupa J, Cullinan P, the ERS Task Force on Specific Inhalation Challenges with Occupational Agents, Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement, Eur Respir J, 2014;43:1573-1587 ...
Occupational asthma (OA) is steadily emerging as the principal cause of respiratory disease due to the workplace environment. One of the key means to ascertain diagnosis of OA is specific inhalation challenge (SIC) with occupational agents. This review: 1) describes the methodology of SIC, with a special emphasis on procedures aimed at increasing the safety and validity of these tests; and 2) outlines the roles of SIC in the diagnosis of OA in clinical and medicolegal assessment, epidemiological studies, surveillance programmes and the investigation of the pathophysiological mechanisms of asthma and OA. We discuss areas of future development, including the development of apparatus which allows exposure of subjects to low and stable concentrations of the occupational agent and the assessment of preventive procedures.. ...
CiteSeerX - Scientific documents that cite the following paper: Diesel exhaust enhances airway responsiveness in asthmatic subjects
TY - JOUR. T1 - Assessment of bronchial responsiveness following exposure to inhaled occupational and environmental agents. AU - Currie, G. P.. AU - Ayres, Jonathan Geoffrey. PY - 2004. Y1 - 2004. M3 - Article. VL - 23. SP - 75. EP - 81. JO - Toxicology. JF - Toxicology. SN - 0300-483X. ER - ...
Bronchoprovocation challenge testing is sometimes used to diagnose asthma if your lung function is normal but you have typical asthma symptoms.
Methacholine tests are widely used as a diagnostic aid for asthma. Their strength has been reputed to be the high sensitivity and very infrequent occurrence of ...
The curators will assemble challenge teams to address specific global issues in the developing and developed worlds, with short- and long-term goals for tackling pressing issues where serious progress is possible.. "Solving the worlds most pressing challenges depends in part on the kind of daring innovations and ideas that MIT is known for - and in fields from water, food, energy, and human health to innovation and education, our faculty are pioneering new answers," MIT Provost Martin Schmidt says. "But lasting solutions to intractable human problems demand ambitious, sustained collaborative action, and require, from us, new ways of working with the world. Through Solve, we are connecting new ideas for action with people who, together, have the power to spark and accelerate meaningful change.". The Solve event will include challenge working groups, student forums, and tours. The specific challenges associated with each pillar will be addressed at the Solve event, and work will continue ...
Welcome to Real Science Real Nutrition! In an effort to bring our customers the highest level of quality products at affordable prices, we have developed an online store that offers added convenience to our customers. We know that natural medicines, vitamins, and herbs play a key role in supporting many of the bodys functions. Whether youre looking to support cardiovascular function, immune function, digestion, or the specific challenges that men and women face, we have a targeted solution for you. Real Science Real Nutrition offers a complete line of professionally formulated, high quality nutritional and dietary supplements at your fingertips. With quick and safe shipping, your health and wellness products can be delivered right to your front door!
Welcome to Real Science Real Nutrition! In an effort to bring our customers the highest level of quality products at affordable prices, we have developed an online store that offers added convenience to our customers. We know that natural medicines, vitamins, and herbs play a key role in supporting many of the bodys functions. Whether youre looking to support cardiovascular function, immune function, digestion, or the specific challenges that men and women face, we have a targeted solution for you. Real Science Real Nutrition offers a complete line of professionally formulated, high quality nutritional and dietary supplements at your fingertips. With quick and safe shipping, your health and wellness products can be delivered right to your front door!
While drinking trends for Whites tend to dominate views of overall drinking trends for the United States, Blacks and Hispanics often face specific challenges
MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level. While they have been implicated in various diseases, the profile changes in allergen inhalation challenge are not clarified in human. We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge. Seven mild asthmatic subjects participated in the allergen inhalation challenge. In addition, four healthy control subjects (HCs) were recruited. MicroRNA profiles in peripheral blood samples (pre-challenge and 2 hours post-challenge) were measured by the NanoString nCounter assay to determine changes in miRNA levels as these asthmatic subjects underwent an allergen inhalation challenge. One common miRNA, miR-192, was significantly expressed in both comparisons; HCs vs. pre-challenge and pre- vs. post-challenge, showing that miR-192 was significantly under-expressed in asthmatics compared to HCs and decreased in post-challenge at an
It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.. ...
In a study of 14 subjects with respiratory symptoms associated with exposure to live fish bait, skin- and serum-specific IgE tests with Lucilia caesar, Galleria mellonella, and Tenebrio molitor extracts were conducted. Thirteen subjects had asthma, all 14 had rhinoconjunctivitis, and 3 had contact urticaria. Eleven subjects had respiratory symptoms after fishing with live bait, and 3 subjects had symptoms during their work in a commercial fish bait farm. The presence of skin- or serum-specific IgE to L. caesar extract was demonstrated in 13 subjects, to G. mellonella extract in 4 subjects, and to T. molitor extract in 3 subjects. After exposure to live fish bait, 2 subjects had an early asthmatic response, 3 had a late asthmatic response, and 2 had no asthmatic response. Late asthmatic response was associated with a long-lasting increase in bronchial responsiveness (8 ...
Wheezing during infancy has been linked to early loss of pulmonary function. We prospectively investigated the relation between bronchial hyperresponsiveness (BHR) and progressive impairment of pulmonary function in a cohort of asthmatic infants followed until age 9 years. We studied 129 infants who had had at least three episodes of wheezing. Physical examinations, baseline lung function tests and methacholine challenge tests were scheduled at ages 16 months and 5, 7 and 9 years. Eighty-three children completed follow-up. Twenty-four (29%) infants had wheezing that persisted at 9 years of age. Clinical outcome at age 9 years was significantly predicted by symptoms at 5 years of age and by parental atopy. Specific airway resistance (sRaw) was altered in persistent wheezers as early as 5 years of age, and did not change thereafter. Ninety-five per cent of the children still responded to methacholine at the end of follow-up. The degree of BHR at 9 years was significantly related to current clinical status
A number of mechanisms have been proposed as the basis for the relationship between nonspecific airway responsiveness and prechallenge pulmonary function. Because resistance to flow through a tube is inversely proportional to the radius to the fourth power, a given degree of bronchoconstrictor-induced circumferential airway narrowing can be expected to cause a proportionally larger increase in airway resistance in a narrow airway than in a wider airway. Intersubject differences in the distribution of resistance along the bronchial tree may influence both the pattern of aerosol deposition and the relative impact on total airway resistance of bronchoconstriction at particular sites such as the peripheral airways. Airway hyperresponsiveness may result in heightened bronchomotor tone prior to challenge and thereby be correlated with reduced prechallenge pulmonary function. The convention of expressing responsiveness in terms of percentage of change in FEV, (eg, PD20FEV,) imposes a mathematical ...
TY - JOUR. T1 - Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging. T2 - A proof of concept study. AU - Renne, Julius. AU - Hinrichs, Jan. AU - Schönfeld, Christian. AU - Gutberlet, Marcel. AU - Winkler, Carla. AU - Faulenbach, Cornelia. AU - Jakob, Peter. AU - Schaumann, Frank. AU - Krug, Norbert. AU - Wacker, Frank. AU - Hohlfeld, Jens M.. AU - Vogel-Claussen, Jens. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours ...
The neurosurgical team has complete and primary control of the patients in the NICU and is therefore very closely involved in their management. Comprehensive monitoring capability is already in place and an excellent full-time research coordinator is on staff. The adult and pediatric hospital buildings are adjacent to each other and are connected by a cross walk. The same resident team covers both age groups. There is an excellent working relationship between the Neurosurgery team, the Trauma Surgery team and other associated services. Cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2879175 • Bronchial provocation tests: the rationale for using inhaled mannitol as a test for airway hyperresponsiveness. Author(s): Leuppi JD, Brannan JD, Anderson SD. Source: Swiss Medical Weekly : Official Journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology. 2002 April 6; 132(13-14): 151-8. Review. cmd=Retrieve&db=pubmed&dopt=A ...
The 547 asymptomatic subjects with normal pulmonary function were grouped according to quintile of prechallenge FEV, (percent predicted), and the fifth percentiles of PD20FEV, within each quintile of FEV, were calculated (Table 2). The fifth percentile of methacholine PD20FEV, increased with increasing quintile of prechallenge FEV,. This relationship is shown graphically in Figure 1, in which the fifth percentile of PD20FEV, for each quintile is plotted against the median FEV, for that quintile. Restricting analysis to a subgroup of 157 lifetime nonsmokers yielded similar values for the fifth percentiles of PD20FEV,, for both overall and FEV,-specific percentiles (data not shown). canadian health & care mall. The overall fifth percentile of PD20FEV, (8.3 (imol) and the FEV,-specific fifth percentiles of PD20FEV, (as indicated in Table 2) respectively defined the 26 (4.8 percent) and 27 (4.9 percent) most responsive subjects among the 547 asymptomatic men. Seventeen (3.1 percent) men were ...
The aim of this study was to assess the effectiveness of an asthma prevalence video questionnaire, a standard written questionnaire based on the IUATLD Bronchial Symptoms Questionnaire and a new written questionnaire designed for an international study of asthma and allergies in childhood ISAAC in predicting bronchial hyper-responsiveness BHR...
TY - JOUR. T1 - Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge. AU - Hunt, L. W.. AU - Gleich, G. J.. AU - Kita, H.. AU - Weiler, D. A.. AU - Schroeder, D. R.. AU - Vuk Pavlovic, Z.. AU - Sur, Sanjiv. PY - 2002. Y1 - 2002. N2 - Background: In patients with quiescent asthma, macrophages are the most prevalent cells recovered by bronchoalveolar lavage (BAL). Through activation via their FcεRII receptors or by acting as antigen-presenting cells, macrophages could, in theory, promote the late airway response to allergen. Objective: In order to investigate the importance of macrophages and other airway luminal cells in inducing the late airway response, a novel washout experiment was designed. Methods: Five patients with ragweed-allergic asthma underwent bronchoscopy and segmental bronchial challenge with either normal saline or short ragweed extract in two segments of one lung. In a third segment of the opposite lung, 12 successive BALs ...
BACKGROUND: It has been postulated that dietary antioxidants may influence the expression of allergic diseases and asthma. To test this hypothesis a case-control study was performed, nested in a cross sectional study of a random sample of adults, to investigate the relationship between allergic disease and dietary antioxidants. METHODS: The study was performed in rural general practices in Grampian, Scotland. A validated dietary questionnaire was used to measure food intake of cases, defined, firstly, as people with seasonal allergic-type symptoms and, secondly, those with bronchial hyperreactivity confirmed by methacholine challenge, and of controls without allergic symptoms or bronchial reactivity. RESULTS: Cases with seasonal symptoms did not differ from controls except with respect to the presence of atopy and an increased risk of symptoms associated with the lowest intake of zinc. The lowest intakes of vitamin C and manganese were associated with more than fivefold increased risks of ...
Using a sensitive single isotope enzymatic assay we measured bronchoalveolar lavage (BAL) fluid histamine in asymptomatic normal (nonallergic), allergic rhinitic, and allergic asthmatic subjects. Normal subjects were found to have little or no detectable amounts of histamine in BAL fluid (11 +/- 11 pg/ml), and few BAL fluid mast cells. In comparison, the allergic rhinitics and allergic asthmatics had much higher amounts of BAL fluid histamine (113 +/- 53 and 188 +/- 42 pg/ml, respectively), and a significantly greater number of BAL fluid mast cells. Furthermore, despite having equivalent baseline pulmonary function values, allergic asthmatics with BAL fluid histamine levels greater than 100 pg/ml required only 7 +/- 2 breath units of methacholine to induce a 20% drop in forced expiratory volume in 1 s (FEV1) (PD20FEV1) while asthmatics with BAL fluid histamine levels less than 100 pg/ml required 49 +/- 19 breath units (P less than 0.05). These data suggest that allergic asthmatics have ongoing ...
PubMed journal article Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary diseas were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. In patients with mild asthma, quilizumab reduced serum IgE and attenuated the early and late asthmatic reaction following whole lung allergen challenge. This study evaluated the efficacy and safety of quilizumab in adults with allergic asthma, inadequately controlled despite high-dose inhaled corticosteroids (ICS) and a second controller. Five hundred seventy-eight patients were randomized to monthly or quarterly dosing regimens of subcutaneous quilizumab or placebo for 36 weeks, with a 48-week safety follow-up. Quilizumab was evaluated for effects on the rate of asthma exacerbations, lung function, patient symptoms, serum IgE, and pharmacokinetics. Exploratory analyses were conducted on biomarker subgroups (periostin, blood eosinophils, serum IgE, and exhaled nitric oxide). Quilizumab was well tolerated and reduced serum total and allergen
the history of asthma asthma tests for adults types of asthma mild persistent treatment for asthma asthma and anxiety asthma coughing dry asthma specialists richmond asthma tests methacholine symptoms of asthma in cats skin asthma clinic A bronchial challenge test is a medical test used to assist in the diagnosis...
The contributions of histamine, cysteinyl leukotrienes (CysLTs) and thromboxane A,SUB,2,/SUB, (TXA,SUB,2,/SUB,) to the asthmatic responses and the magnitudes of blood and lung eosinophilia at acute and chronic stages of our asthmatic model were comparatively determined. Guinea pigs were alternately sensitized/challenged by inhalation with ovalbumin+Al(OH),SUB,3,/SUB, and ovalbumin, once every 2 weeks. Effects of mepyramine, pranlukast (a CysLT antagonist) and seratrodast (a TXA,SUB,2,/SUB, antagonist) on the early (EAR) and/or the late asthmatic response (LAR) were assessed at the second and fourth antigen challenges. The second challenge caused EAR but not LAR. Although the EAR was decreased at the fourth challenge, a substantial LAR was seen. Both mepyramine and seratrodast inhibited the EAR at the second challenge by approximately 50%. However, at the fourth challenge, these drugs did not inhibit the EAR. The LAR at the fourth challenge was attenuated by pranlukast and seratrodast by 45% and ...
The aim of this study was to assess prevalence of asthma and allergy in the non-polluted mountain area of Upper Hallingdal, Norway. All schoolchildren (7-16 years) who in a previous questionnaire survey (n = 1177) reported sometime asthma were enrolled in group I (n = 80), the 59 who reported asthma-like symptoms in the past 12 months formed group II, and 77 of the healthy controls were randomly selected as group III. All 216 children underwent clinical examination, skin prick test, spirometry, bronchial provocation (PD20 metacholine) and treadmill exercise test. Subsequently they were reclassified as (1) healthy, never had asthma or symptoms, (2) symptoms not confirmed as asthma, (3) previous asthma, now healthy, (4) current asthma. Lifetime asthma prevalence was 10.2%. Based upon clinical examination, the specificity and sensitivity of the questionnaire for asthma diagnosis were 88 and 74%, respectively. Forced vital capacity was significantly higher among the asthmatics (group 4 versus 1), ...
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In order to diagnose and monitor asthma, your healthcare provider examines you. He or she listens to your chest and asks you to breathe. You are asked questions about your symptoms, triggers, and any family history of asthma or allergies. Special lung function tests may also be done. One of these is called a spirometry test.. ...
Our study investigated if airway hyperresponsiveness (AHR) at asthma onset could predict FEV1 decline in treated asthmatics. We retrospectively recruited 275 subjects that had performed a methacholine test at asthma onset and FEV1 measurements after 5-10 years. We subdivided subjects into three groups, according to their AHR level. 65 patents had normal reactivity (25 males; mean age 46±15; mean baseline FEV1%:96.1±20); 78 were borderline/mild AHR (PD20,400µg) (26 males; mean age 43±14; mean baseline FEV1%:102±12; mean PD20:1120±696) and 132 showed moderate/severe AHR (PD20≤400µg; 51 males; mean age 43±14; mean baseline FEV1%: 94±13; mean PD20:185±108). Annual FEV1 declines (the differences between the first and last measurements, divided by the number of years separating them) were compared. Average annual FEV1 declines (after 7±2 years) were similar in all groups: 46.2±81 ml/yr in normal reactivity subjects, 53±65 in borderline/mild AHR and 45±62.5 in moderate/severe AHR ...
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While men are prone to act on their anger, woman tend to renounce it. What are some of the specific challenges women face in dealing with anger?
Populism has had as many incarnations as it has had provocations, but its constant ingredient has been resentment, and hence whininess.
TY - JOUR. T1 - The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. AU - Haczku, Angela. AU - Atochina, Elena Nikolaevna. AU - Tomer, Yaniv. AU - Cao, Yang. AU - Campbell, Colleen. AU - Scanlon, Seth T.. AU - Russo, Scott J.. AU - Enhorning, Goran. AU - Beers, Michael F.. PY - 2002/10. Y1 - 2002/10. N2 - Pulmonary surfactant dysfunction may significantly contribute to small airway obstruction during the asthmatic response, but neither its exact role nor its regulation is clear. Surfactant function and composition was studied in an Aspergillus fumigatus (Af)-induced late-phase allergic airway response in sensitized BALB/c mice. The peak of Af-induced airway hyperresponsiveness in sensitized and challenged mice 24 h after allergen provocation coincided with a significant fall in surface activity of the pulmonary surfactant. The underlying changes included time-dependent elaboration of eotaxin and IL-5 followed by eosinophil influx into the ...
STUDY OBJECTIVE: This study examined the impact on childrens respiratory health of a government air quality intervention that restricted the sulphur content of fuels to 0.5% from July 1990 onwards. DESIGN/SETTING/PARTICIPANTS: This study examined the changes, one and two years after the introduction of the intervention, in airway hyperreactivity of non-asthmatic and non-wheezing, primary 4, 5, and 6, school children aged 9-12 years living in a polluted district compared with those in a less polluted district. Bronchial hyperreactivity (BHR)(a 20% decrease in FEV1 provoked by a cumulative dose of histamine less than 7.8 mumol) and bronchial reactivity slope (BR slope) (percentage change in logarithmic scale in FEV1 per unit dose of histamine) were used to estimate responses to a histamine challenge. The between districts differences after the intervention were studied to assess the effectiveness of the intervention. MAIN RESULTS: In cohorts, comparing measurements made before the intervention ...
Wilson, AM, Gray, RD, Hall, IP and Lipworth, BJ (2006) The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma. Allergy, 61 (2). pp. 254-259. ISSN 1398-9995 Full text not available from this repository. (Request a copy ...
Allergen inhalation by atopic asthmatics in the laboratory results in most of the manifestations of asthma, including reversible airflow obstruction, AHR and airway inflammation. This methodology has been used to examine the mechanisms of eosinophil, T-cell, and dendritic cell trafficking to/from the bone marrow to/from the blood and to the airways. The current proposal will capitalize on the unique opportunity offered by this allergen-specific model of direct bronchial challenge, by using MHC class II allergen tetramer reagents to enrich and characterize, ex vivo, Fel d 1 epitope-specific T cells before and after a localized bronchial allergen challenge. The over arching hypothesis of this proposal is that trafficking of allergen-specific T cells (tetramer+) from the blood to the airways and bone marrow is associated with the development of the late asthmatic reaction. This study will measure the frequency of Fel d 1-specific T cells, how these cells traffic between relevant compartments ...
My humble answer: There really is no difinitive test to diagnose asthma. However, the methacholine challenge is a pretty significant indicator. If you have a negative methacholine challenge chances are you dont have asthma. The reason I can say this is because if you have asthma the challenge will make you short of breath, and a bronchodilator breathing treatment will make you feel better. If none of these happen, chances are you dont have asthma. A second opinion is always a good idea, however. ...
Clinical Assessment Pre-test Probability score Specific- IgE Tests  Skin Prick Tests  Prick-Prick Test  Serum IgE levels o Immuno-CAP (RAST) Provocation Tests  Oral Challenge  DBPCFC  Nasal & Bronchial Challenges Test for Delayed Hypersensitivity  Patch Tests o Contact Dermatitis o Delayed food reactions o Drug reactions
STUDY OBJECTIVE: To compare the physiologic and inflammatory response following inhalation of corn dust extract (CDE) and lipopolysaccharide (LPS) solutions in normal subjects. DESIGN: Randomized, double-blind crossover design. PARTICIPANTS: Fourteen healthy, nonatopic, nonasthmatic, never-smoking volunteers. INTERVENTIONS: On separate visits, subjects underwent a series of four inhalation challenges to LPS or CDE, each containing either a high (6 micrograms/mL) or low (0.9 microgram/mL) endotoxin concentration, and administered at equal Xolumes. RESULTS: Chest tightness, cough, dyspnea, and sputum production were experienced following both LPS and CDE exposures and with similar frequency at both high and low endotoxin concentrations. LPS and CDE inhalations caused acute declines in FEV1, and the changes in FEV1 from baseline following exposure to both inhalants were not significantly different at both high and low endotoxin concentrations. Following exposure to the high-endotoxin LPS and CDE, no
The fastest and most accurate way to assess body plethysmography and DLCO module for standard testing like lung volume(TGV,TLC,FRC etc ),slow vital capacity(SVC), maximum voluntary ventilation(MVV),MIP/MEP, respiratory drive, bronchial challenge test, absolute and specific conductance of airway(GAW/SGAW)absolute and specific airway resistance ...
in International Journal of Clinical Practice (2012), 66(2), 158-65. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of ... [more ▼]. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M ,/= 16 mg/ml) and to establish whether or not symptoms relate to FE(NO50) and PC20M in patients with no demonstrated reversibility to beta(2) -agonist. Methods: We conducted a prospective study on 174 steroid naive patients with respiratory symptoms, forced expiratory ...
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2016 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 121, no 3, p. 198-198Article in journal, Letter (Refereed) Published ...
The irritant challenge test evaluates how sensitive the airways in your lungs are when exposed to a specific chemical or irritant. A spirometry breathing test is done before and after the exposure.
10 causes of an itchy face. How does a hot flash feel?. Q&A: LGBT patients with Alzheimers disease and their caregivers face specific challenges. New study aims to understand surrogate decision challenges for LGBT patients with Alzheimers. Win a Dude Ranch Vacation in Random Drawing. The...
Bring us to your location! Rigging for Rescue is the product of considerable research and development and has been given on contract to various groups across the continent from state fire academies to industrial rescue teams and mountain rescue specialists. When there are six or more people from your organization or vicinity interested in participating in a Rigging for Rescue seminar, arranging one at your location may better meet your needs.. A contract seminar enables you to utilize the geography, equipment, machinery, buildings and problem sites that are a specific challenge to your organization. Other advantages include reducing training expenses, providing training to a greater number of people and building teamwork. In order to ensure a "full" seminar and minimize expenses, some organizations have chosen to extend an invitation to other groups and organizations in their area, some of which they perform mutual aid with. This has worked well numerous times and can be fairly straight forward ...
I think this might be the right section to start a thread thats not about any specific diet nor a specific challenge. 6 months is plenty of time to
Hello everyone, I have had a few things going on lately. First I had a dilatation of the esophagus on the 30th October and so far I feel the same....food still feels like it is getting stuck. Does this get better? My GI doctor couldnt do the stretch he wanted to do as I couldnt fit the adult mouth piece in my mouth so had to opt for a smaller one, which meant he couldnt do the medium stretch. I am wondering if that may be the reason why I havent noticed an improvement. Sorry, that was just what has happened the last month. This month I went for pulmonary function testing. the first lot of tests which tested volume etc were all okay but today I had the provocation tests and it showed I am hypersensitive. Which boiled down to my numbers (I dont know what that was either? was trying to breathe while they were explaining things to me) dropped the 15% very quickly before the test was completed. I was in distress, but once they gave me the ventolin, I was alright after about 6 puffs of it. My ...
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Addressing the issue of whether to grant a second inter partes review (IPR) after all of the claims had previously been adjudicated, the Patent Trial…
Club cell secretory protein (CC-16) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic lung diseases because of its presumed relationship to inflammation. Little is known about the association between CC-16 serum level and asthma, lung function and airway responsiveness (AR). Serum CC-16 level was determined by latex immunoassay in 1298 participants from the French Epidemiological case-control and family-based study on Genetics and Environment of Asthma (EGEA) (mean age 43 years; 49% men, 38% with asthma). Pre-bronchodilator lung function (forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC) and degree of AR, expressed as a function of the dose-response slope to methacholine test were measured. Standardized residuals CC-16 z-scores were obtained by regressing CC-16 level on the glomerular filtration rate. CC-16 z-scores were correlated with asthma, lung function and AR in participants with and without asthma.
Asthma is one of the most common clinical symptoms in Churg-Strauss syndrome (CSS). However, it is not known how lung function and bronchial hyperresponsiveness (BHR) prior to the development of CSS differs from asthmatics do not develop CSS. This retrospective cohort study was conducted to predict the onset of CSS and facilitate diagnosis in the early phase of the disease. We examined 24 pre-CSS asthmatic patients and 294 non-CSS asthmatic patients for clinical features, percent forced expiratory volume at 1 second (%FEV1), BHR to acetylcholine, and evaluated eosinophils (%) in the peripheral blood at their first hospital visit for asthma treatment. All of the 24 pre-CSS patients had adult-onset asthma. The asthma of 87.5% of pre-CSS patients at the first hospital visit before the onset of CSS was severe and was complicated by sinusitis. The eosinophils (%) in the peripheral blood was significantly higher than in non-CSS asthmatic patients. The %FEV1 in both the patients with severe asthma and ...
Ryo, U.Y.; Kang, B.; Townley, R.G., 1976: Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine
P.H. Howarth, B.S. Sihra, S.T. Holgate; The Influence of Non-Specific Airway Reactivity on the Immediate Bronchoconstrictor Response to Exercise and Antigen in Asthma. Clin Sci (Lond) 1 January 1984; 67 (s9): 33P. doi: https://doi.org/10.1042/cs067033P. Download citation file:. ...
TY - JOUR. T1 - Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness. AU - Fu, Chi Ling. AU - Ye, Yi Ling. AU - Lee, Yueh L.. AU - Chiang, Bor Luen. PY - 2006/5/8. Y1 - 2006/5/8. N2 - Background: An increasing prevalence of allergic diseases, such as atopic dermatitis, allergic rhinitis and bronchial asthma, has been noted worldwide. Allergic asthma strongly correlates with airway inflammation caused by the unregulated production of cytokines secreted by allergen-specific type-2 T helper (Th2) cells. This study aims to explore the therapeutic effect of the airway gene transfer of IL-12, IL-10 and TGF-β on airway inflammation in a mouse model of allergic asthma. Methods: BALB/c mice were sensitized to ovalbumin (OVA) by intr aperitoneal injections with OVA and challenged by nebulized OVA. Different cytokine gene plasmids or non-coding vector plasmids were instilled daily into the trachea up to one day before the inhalatory OVA ...
P.H. Howarth, J.S. Mann, S.T. Holgate; The Influence of Resting Airway Calibre on Non-Specific and Specific Airway Reactivity in Asthma. Clin Sci (Lond) 1 January 1984; 67 (s9): 5P-6P. doi: https://doi.org/10.1042/cs067005Pb. Download citation file:. ...
Modulating response among children with atopic asthma:29 In this study published in the International Journal of Food Sciences and Nutrition, 11 children (six girls and five boys) underwent a spirometry, methacholine provocation testing and blood testing for serum IgE lymphocyte glutathione (GSH) before and after a month of taking a whey-based oral supplement (a 10-gram dose taken twice a day).. The researchers chose to examine the effects of a whey-based oral supplement among children with atopic asthma because it is a T-helper type 2 (Th2) cytokine disease, and supplementation is said to help improve lung function and decrease atopy. Initially, the researchers discovered that GSH levels in antigen-presenting cells promoted a Th2 cytokine response in mice.. Results showed a decrease in IgE levels after supplementation, but there were no significant changes in lymphocyte GSH or baseline forced expired volume in 1 second (FEV1) levels for the group as a whole.. Based on this study, whey protein ...
Tale M. Torjussen, Karin C. Lødrup Carlsen, Monica C. Munthe-Kaas, Petter Mowinckel, Kai-Håkon Carlsen, Peter J. Helms, Jorrit Gerritsen, Moira K. Whyte, Warren Lenney, Dag E. Undlien, Kevin V. Shianna, Guohua Zhu and Sreekumar G. Pillai Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: Effects on bronchial hyperresponsiveness in children Pediatric Allergy and Immunology 23. Version of Record online: 21 OCT 2011 , DOI: 10.1111/j.1399-3038.2011.01222.x. Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf. Required = Required Field. ...
EDITOR, - Kjell Larsson and colleagues described the high prevalence of asthma and increased bronchial responsiveness in cross country skiers in Sweden.1 They attributed their findings to the skiers breathing large volumes of cold air during strenuous exercise. They should, in addition, consider other factors causing bronchoconstriction such as humidity, hypocapnia, and hypoxia.. Absolute humidity is depressed at reduced … ...
PAIRED ACUTE INHALATION TEST REVEALS THAT ACETALDEHYDE TOXICITY IS HIGHER IN ALDEHYDE DEHYDROGENASE 2 KNOCKOUT MICE THAN IN WILD-TYPE MICE (2005 ...
The Report United Kingdom Kraken Project Panorama - Oil And Gas Upstream Analysis Report provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz" United Kingdom Kraken Project Panorama, GlobalDatas latest release, presents a comprehensive overview of the asset. This upstream report includes detailed qualitative and quantitative information on the asset, provides a full economic assessment and reflects several parameters including (but not limited to) geological profile, asset development and specific challenges. Based on this analysis, future outlook for the asset is presented…. Read More ...
Lallemand Health Solutions. Quality Probiotics. Complete Solutions. , 23-Nov-2017 , Technical / White Paper A mature microbiota is achieved after 3 years old as demonstrated by recent studies. Yet kids and teens face specific challenges where probiotics can play... ...
The IUPHAR/BPS Guide to Pharmacology. methacholine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
This is real. This is happening. These are the deadly serious petty provocations of the leader of the worlds most powerful nation - a man who holds the office once widely regarded as leading the free world.. ...
Nitrogen dioxide (NO2) can enhance both early and late airway narrowing after inhaled antigen in allergic asthmatic subjects. We hypothesized that NO2 may also increase airway inflammation during the late response. Nitrogen dioxide has been shown to cause airway inflammation in healthy subjects without asthma. We also hypothesized that individuals with asthma may have increased non-allergic airway inflammation after exposure to NO2. To test these hypotheses, we designed two experiments with the following specific aims: Experiment 1) To determine the effect of a single exposure to NO2 on allergen-induced airway inflammation. Experiment Two: To determine the effect of NO2 exposure on non-allergic airway inflammation. Experiment One: 15 house dust mite (HDM)-sensitive asthmatic subjects were exposed for 3 hours to filtered air or 0.4 ppm NO2 followed immediately by inhalation of HDM allergen. Lung function was measured before and after each exposure and after allergen challenge, hourly for 6 hours. Sputum
Molecular profiling of exhaled volatile organic compounds (VOC) by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD. However, it is unknown whether this is determined by differences in airway caliber. We hypothesized that breathprints obtained by electronic nose are independent of acute changes in airway caliber in asthma. Ten patients with stable asthma underwent methacholine provocation (Visit 1) and sham challenge with isotonic saline (Visit 2). At Visit 1, exhaled air was repetitively collected pre-challenge, after reaching the provocative concentration (PC20) causing 20% fall in forced expiratory volume in 1 second (FEV1) and after subsequent salbutamol inhalation. At Visit 2, breath was collected pre-challenge, post-saline and post-salbutamol. At each occasion, an expiratory vital capacity was collected after 5 min of tidal breathing through an inspiratory VOC-filter in a Tedlar bag and sampled
Nonspecific bronchial hyperreactivity (BHR) has been reported to occur in patients with bronchiectasis. To evaluate this further, we studied 77 patients with stable bronchiectasis (noncystic fibrosis) with special reference to the prevalence of BHR to methacholine (MCh), and its relation to lung function, sputum characteristics, concommitant asthma, and atopy. The concentration of MCh required to produce a fall of 20% in forced expiratory volume in 1 s (FEV 1), PC 20, was determined by Wrights nebulization tidal breathing method. BHR defined by a PC 20 ≤ 8 mg/ml was found in 21 of 47 (45%) subjects who underwent bronchial challenge. Presence of BHR was positively associated with low baseline spirometric values, diagnosis of asthma, long duration of disease, and elevated total IgE on univariant analysis, and was significantly related to FEV 1/forced vital capacity (FVC) ratio and asthma on multiple regression analysis. Ten of the 21 hyperreactive subjects did not have clinical asthma, whereas ...
The study is a part of the European Community Respiratory Health Survey. A random sample (n=351) of 20-44-year olds and persons of the same age with asthma-like symptoms or current asthma medication according to a postal questionnaire (n=95) were studied. Interview was taken, methacholine challenge was done and ECP, total and specific IgE were measured from serum. The median S-ECP value was 8.0 µg/l in the random sample. The geometric mean of S-ECP was higher in subjects with, than without atopy (10.2. vs 8.9 µg/l, P < 0.01) and in subjects with bronchial hyperresponsiveness (BHR) than in subjects without BHR (9.9 vs 8.0 µg/l, P ...
Local Lung Function And Airway Size Response During Methacholine Challenge And Salbutamol Treatment Measured Using High-Resolution Dynamic CT And Functional Lung Imaging
Discussion BHR occurred in 21%, and 6% presented BHRms. The latter is in line with the reported prevalence of physician-diagnosed asthma (7%) in Helsinki (6). We found no discrepancy with results of the European Community Respiratory Health Survey in which the prevalence of BHR ranged from 3% to 28% among 16 countries, with a median prevalence of 13% (34).. We assessed BHR by two cut-off levels of PD15FEV1 indicating different severity levels of BHR, thus showing variations and differences in importance of the determinants assessed. For most of the determinants, ORs were higher, parallel with BHR severity. Our results, however, revealed that some risk factors for BHR and asthma, like severe respiratory infection in childhood, were associated with the higher PD15FEV1 cut-off level only.. The strongest determinant of BHR was decreased FEV1 (,80% of predicted) when combined with airway obstruction (defined as FEV1/FVC , 88% of predicted). But, studies on the association of BHR with allergic ...
We can test the effectiveness of your compound against these parameters. We have previously demonstrated efficacy of bronchodilator drugs (β2 agonists, anticholinergics, Rho-kinase inhibitors) and anti-inflammatory drugs (glucocorticopsteroids, arginase inhibitors) in this model.. A unique feature of this model is that guinea pigs can be instrumented using a balloon catheter to measure lung function online in freely moving unrestrained animals. This way, not only hyperresponsiveness to histamine, but also the nature and size of the early and late asthmatic response can be measured including effects of pharmacological treatments hereon. This can be done without the need for surgical interventions during the treatment period, without the need for anaesthesia (which effectively blocks the neural component of airway hyperresponsiveness) and with the possibility of repeated and on-line measurements in time.. Furthermore, the guinea pig offers a number of unique characteristics that make the model ...
BACKGROUND: Inhalation of swine house dust induces acute airway inflammation and increased bronchial responsiveness in healthy subjects. OBJECTIVE: The aim of the study was to investigate whether 5-lipoxygenase products such as leukotrienes may have a role in this reaction. METHODS: Twenty-three healthy subjects were randomised into two groups receiving treatment with either zileuton (600 mg) or placebo four times a day. After 5 days of treatment, all subjects were exposed for 3h in a swine barn. Bronchial responsiveness, exhaled nitric oxide (NO), and mediators in nasal lavage (NAL), blood and urine were measured before and after the exposure. RESULTS: The exposure induced an increased bronchial responsiveness to methacholine in both groups with 2-3 doubling concentration steps, no significant difference between treatments. Leukotriene E(4) in urine increased significantly following exposure in the placebo group from 37.3 (29.1-45.6) (mean (95% confidence interval)) ng/mmol creatinine to 47.7 ...
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TY - JOUR. T1 - Airway hyperresponsiveness. T2 - From molecules to bedside. AU - Sieck, Gary C. PY - 2003/7/1. Y1 - 2003/7/1. UR - http://www.scopus.com/inward/record.url?scp=0038309533&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0038309533&partnerID=8YFLogxK. M3 - Article. C2 - 12794089. AN - SCOPUS:0038309533. VL - 95. SP - 1. EP - 2. JO - Journal of Applied Physiology. JF - Journal of Applied Physiology. SN - 8750-7587. IS - 1. ER - ...
Exercise Challenge Week of 9-4-to-9-10 Come back and let us know how you are doing. Sunday- Monday- Tues- Wed- Thurs- Fri- Saturday- Sunday- , team51955board
Asthma is a heterogeneous disease or an inflammatory disorder of the airway related to the airflow impediment and bronchial hyper-responsiveness which ranges in severity across the continuum of the diseases. Here, adequate control cannot be achieved in a considerable ratio thought the application of possible treatments
I was originally going to let Leslie and Ashley attend WAGR Weekend and then determine through their feedback whether or not I would attend in the future, a mistake I am glad I did not make. This weekend was one of the most eye-opening and rewarding experiences of recent memory.. Ashley is twenty-one years old and we have navigated the trials and tribulations of dealing with a developmentally challenged daughter without the knowledge of her specific challenges or needs. We knew that we would have some difficulties after speaking with the dysmorphologist while Ashley was an infant but the challenges grew and evolved in their complexity over the years. With time we developed strategies to minimize the difficult situations but still struggled with many behaviors.. It was inspiring to spend time with a group of families and their children, challenged and not, and to see that similar challenges are experienced by all. Even more inspiring are the siblings of our special children and the love and ...
This Strategic Analysis Service analyzes market trends in the Global In Vitro Diagnostics market since 2003, predicts future changes in market measurements through 2010, and discusses specific challenges facing industry participants and strategic recommen
This level of control and precision has simply not been broadly available to the pharmaceutical industry before.. PRINT particles can be designed to address specific pharmacological or therapeutic objectives, such as optimizing the route of administration, improving solubility, enhancing stability or extending therapeutic effects, thereby improving efficacy, safety and convenience for the patient.. This simple, elegant solution is applicable to virtually any therapeutic area or molecule, and offers the opportunity to engineer a range of medicines, including drugs and biologics, single agents and combinations, and vaccines.. Drug delivery technologies have been hampered in adapting to specific challenges, including molecules chemistry. By controlling size, composition and/or shape, the PRINT technology can deliver on the potential of drug delivery to improve medicines broadly.. Shifting economics for pharmaceutical companies have elevated the importance of cost and quality management. PRINT ...
In this article, a class of architecture design problems is explored with perfect matchings (PMs). A perfect matching in a graph is a set of edges such that every vertex is present in exactly one edge. The perfect matching approach has many desirable properties such as complete design space coverage. Improving on the pure perfect matching approach, a tree search algorithm is developed that more efficiently covers the same design space. The effect of specific network structure constraints (NSCs) and colored graph isomorphisms on the desired design space is demonstrated. This is accomplished by determining all unique feasible graphs for a select number of architecture problems, explicitly demonstrating the specific challenges of architecture design. With this methodology, it is possible to enumerate all possible architectures for moderate scale-systems, providing both a viable solution technique for certain problems and a rich data set for the development of more capable generative methods and ...
Movie [ARM-532] Provocation Pheromone ... Female Teacher Of Comfort Is Im Troubled Past Villainess ... Hanasaki Comfort produced by Aroma Kikaku,.
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A: Well, first of all, why are we not playing? It wasnt a decision the players made. We indicated from our first proposal they (the players) were willing to see their percentage fall over time. The owners first proposal went enormously backwards, so the movement theyve made since then is from a proposal that nobody - not even them - took seriously to begin with. So you go into buy a car and lets say it has a $35,000 sticker on it and you offer 15. The dealer laughs at you and says, maybe 33. And you say, No, Ill improve my offer to 20. I improved it 33 percent. Well it still doesnt mean it has any reasonable chance of success at any point. Its an improvement off a number that had zero chance of success. And so you have to view their position from that standpoint. When we came in (August 14), we came in with a real offer from the beginning, what I had hoped for is a real negotiation. So far we havent had it ...
... bronchial provocation tests MeSH E01.370.386.700.150 --- capnography MeSH E01.370.386.700.250 --- exercise test MeSH E01.370. ... Nasal provocation test MeSH E01.370.386.700 --- respiratory function tests MeSH E01.370.386.700.050 --- airway resistance MeSH ... intradermal tests MeSH E01.370.750.300.400 --- kveim test MeSH E01.370.750.300.750 --- skin test end-point titration MeSH ... intradermal tests MeSH E01.450.495.750.300.540 --- kveim test MeSH E01.450.495.750.300.750 --- skin test end-point titration ...
He did not wait long after his admission into that assembly in bringing their predictions to the test. Parliament met on 19 ... For several years Cobden had been suffering severely at intervals from bronchial irritation and a difficulty of breathing. ... Napoleon was represented as contemplating a sudden and piratical descent upon the British coast without pretext or provocation ...
... and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical ... Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of ...
Leukotriene D4 Bronchial Provocation Test (LTD4-BPT) as an Indicator for the Use of Leukotriene Receptor Antagonist (LTRA). The ... Could Leukotriene D4 Bronchial Provocation Test be a Clear Indicator for Predicting Therapeutic Outcomes of Leukotriene ... Objective4To investigate whether leukotriene D4 bronchial provocation test (LTD4-BPT) could be an indicator of actual ... We aimed to test whether there would be certain parameters that assist prediction of anticipated outcome. ...
Background The International Olympic Committee-Medical Commission (IOC-MC) accepts a number of bronchial provocation tests for ... The role of the bronchial provocation challenge tests in the diagnosis of exercise-induced bronchoconstriction in elite ... The role of the bronchial provocation challenge tests in the diagnosis of exercise-induced bronchoconstriction in elite ... elite swimmers were evaluated on separate days for the presence of EIB using 3 different bronchial provocation challenge tests ...
Antigen Bronchial Provocation Tests, Bronchial Allergen Challenge, Inhalation Provocation Tests. Scope note: Tests involving ... found: MeSH browser, June 12, 2007(Bronchial Provocation Tests. Entry terms: Allergen Bronchial Provocation Tests, Allergen ... "Bronchial provocation tests" to: * How many floors does a two-story house have?. ... Aas, Kjell, 1924- bronchial pr. Spector, Sheldon L. Provocatio. Spector, Sheldon L. Provocativ. ...
... or pulmonary function or breathing tests, can show how well your lungs and airways are working, help diagnose respiratory ... Bronchial provocation test. A bronchial provocation test may be recommended to help diagnose asthma and determine its severity ... Other tests available at respiratory departments in teaching hospitals include exercise testing, bronchial provocation tests ( ... Lung function tests. Lung function tests, also called pulmonary function tests or breathing tests, are tests that can be done ...
OBJECTIVES: Bronchial provocation tests that assess airway hyperresponsiveness (AHR) are known to be useful in assisting the ... OBJECTIVES: Bronchial provocation tests that assess airway hyperresponsiveness (AHR) are known to be useful in assisting the ... We reviewed the use of bronchial provocation tests that use stimuli that act indirectly for monitoring the benefits of inhaled ... CONCLUSIONS: Non-responsiveness to indirect bronchial provocation tests following inhaled corticosteroids occurs weeks to ...
The methacholine bronchial provocation test (MBPT) is highly sensitive and widely used to detect and quantify AHR [3,4]. AHR ... 1. The methacholine bronchial provocation test (MBPT) is highly sensitive and has been widely used to detect and quantify ... MBPT, methacholine bronchial provocation test; BMI, body mass index; FEV1, forced expiratory volume in 1 second; pred., ... The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since ...
Bronchial Hyperresponsiveness in Skiers: Field Test versus Methacholine Provocation?. STENSRUD, TRINE; MYKLAND, KJELL VEGARD; ...
Bronchial Provocation or Challenge Tests. *Methacholine challenge: Methacholine is a known asthma trigger that, when inhaled, ... Pulmonary Function Tests (PFTs). Pulmonary function tests (PFTs) are a series of different breathing tests led by a trained ... Airway resistance is a test that measures how easy it is for the air to move in and out of your lungs. It is an easy test to do ... For this test, you may be asked to breathe quickly, forcefully, or slowly. The test is always repeated at least three times and ...
Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble ...
Methacholine Challenge Testing. Synonyms. Mecholyl challenge, bronchial provocation test. Indications. It is used diagnose ... Six-Minute Walk Test. Background. The six-minute walk test (6mwt) is a test that can aid in assessing the functional capacity ... ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. ... CPX test is used for evaluation of dyspnea that is out of proportion to findings on static pulmonary function tests, ...
Bronchial Provocation testing: Spirometry is used before and after inhalation of Methacholine spray to assess the sensitivity ... Pulmonary Exercise Tests We Perform:. *Six-Minute Walk Test: Walking test used to assess physical fitness and or the need for ... Please call directly for testing information at those locations.. Pulmonary Function Tests We Perform: *Spirometry: Measures ... High Altitude Simulation Testing: Used for some people with lung disease who are planning to travel in an airplane or who wish ...
Environmental allergy testing. Other tests may include:. *Bronchial Provocation Test. *Exercise-Induced Bronchoconstriction ... Pre-Admission Testing*During Your Stay*Leaving BIDMC*Billing and Financial Assistance*Medical Records*PatientSite*Conversation ... Your doctor may have you perform a number of tests to evaluate breathing. These may include:. *Detailed medical history and ...
Bronchial provocation test Make indication of and interpretation results of unspecific bronchial provocation test ... test of reversibility 3. Peak-flow monitoring Make indication and guidance for peak-flow monitoring, as well as read and ... The project can be based on already collected data that is suitable for the testing of certain hypotheses. The physician must ... The project can be based on already collected (Clinical data monitoring) that is suitable for the test of certain hypotheses. ...
bronchial provocation tests. *lung volume measurements. *chronic obstructive pulmonary disease. *genetics. *β2 adrenergic ... Differences in mean NSBH were compared by the Wilcoxon test since these data were not normally distributed. All tests were ... Tracey M, Villar A, Dow L, et al. The influence of increased bronchial responsiveness, atopy, and serum IgE on decline in FEV1 ... We also tested whether there was a relationship between these polymorphisms and NSBH measured using inhalation of methacholine ...
Whereas a high prevalence of bronchial abnormalities has been reported in endurance athletes, its underlying mechanisms and ... Bronchial Hyperreactivity / diagnosis*, epidemiology. Bronchial Provocation Tests. Bronchitis / diagnosis*, epidemiology. ... Both BHR and bronchial obstruction at rest with subsequent expiratory flow limitation during exercise may promote respiratory ... STUDY OBJECTIVES: The purpose of this study was to assess the following: (1) bronchial responsiveness to methacholine and to ...
... atopic sensitization and bronchial hyperresponsiveness was compared in a random sample of adults, 20-44 yrs of age, in two ... Bronchial Hyperreactivity / epidemiology*. Bronchial Provocation Tests. Cross-Sectional Studies. Female. Germany / epidemiology ... methacholine or bronchodilator test, skin test, and total and specific immunoglobulin E (IgE) measurements, with a total number ... Respiratory Function Tests. Respiratory Hypersensitivity / epidemiology*. Respiratory Tract Diseases / epidemiology*. Risk ...
The tests performed include:. *Blood gas analysis. *Bronchial provocation. *Bronchodilator responsiveness. *CPAP titration ... Testing. Diagnosis of some pulmonary diseases requires certain types of testing. Akron General offers a wide range of tests, ... Pulmonary function tests are specialized breathing tests performed to "fingerprint" the breathing cycle. These tests help to ... In addition to certain types of tests, sometimes pulmonary diseases can be diagnosed using non- invasive imaging, including:. * ...
The aim of this cross-sectional study was to assess the prevalence and characteristics of bronchial hyperresponsiveness (BHR) ... bronchial provocation tests; occupational exposure; smoking. Hrčak ID: 12907. URI. https://hrcak.srce.hr/12907 ... "Bronchial Hyperresponsiveness in Women Cooks and Cleaners." Arhiv za higijenu rada i toksikologiju, vol. 58, br. 2, 2007, str. ... Bronchial Hyperresponsiveness in Women Cooks and Cleaners. Jovanka Karadžinska-Bislimovska Jordan Minov Snežana Risteska-Kuc ...
Bronchial Provocation Tests * Child * Female * Forced Expiratory Volume * Humans * Hypersensitivity, Immediate / diagnosis ... Current wheeze, airways hyperresponsiveness (AHR), and skin test positivity to inhaled allergens were all significantly less ... class completed a respiratory symptom questionnaire and underwent allergy skin tests and a methacholine bronchoprovocation test ...
Bronchial Provocation Tests. Humans. Hydrogen-Ion Concentration. Male. Methacholine Chloride / diagnostic use. Mucociliary ...
Inovas pulmonary diagnostics program provides testing and treatment to assist referring healthcare providers with your lung ... Inovas pulmonary diagnostics program provides testing and treatment to assist referring healthcare providers with your lung ... Other Testing. *Arterial Blood Gas. *Bronchial Provocation Challenge. *Sputum Induction. Treatments. *Pentamidine Aerosol ... Tests and Treatments. Inovas Pulmonary Diagnostics Program offers the following tests and treatments:. Pulmonary Function ...
Bronchial Hyperreactivity / complications * Bronchial Hyperreactivity / diagnosis* * Bronchial Provocation Tests * Cohort ... These risks were adjusted for sex, age, smoking, lung function, body-mass index, positive skin tests, eosinophilia, asthma, and ... who had histamine challenge test data, from 1964-72 for 30 years. Follow-up was 99% successful (29 patients lost to follow-up) ...
A histamine bronchial-challenge test revealed bronchial hyperresponsiveness in 95% of the children who had … ... Bronchial Provocation Tests * Child * Child, Preschool * Dermatitis, Atopic / complications* * Dermatitis, Atopic / ... A histamine bronchial-challenge test revealed bronchial hyperresponsiveness in 95% of the children who had a history of ... wheezing or asthma and who could perform the test reliably, indicating that most of them did indeed have asthma. Children with ...
... can be studied by bronchoprovocation test (BPT) using direct (methacholine - MCh) or indirect (adenosine 5-monophosphate - AMP ... Bronchial Hyperreactivity / diagnosis*. Bronchial Provocation Tests. Cough / physiopathology*. Cross-Over Studies. Female. ... A minority (c. 10%) of CVA patients have EAHR as measured by these tests, while most had AHR as assessed with each of the ... BACKGROUND: Airway hyperresponsiveness (AHR) can be studied by bronchoprovocation test (BPT) using direct (methacholine - MCh) ...
  • We performed nasal provocation testing on 62 patients to establish an unbiased screening criterion for study entry. (thefreelibrary.com)
  • Acoustic rhinometric measurements of the nasal responses revealed that 34 patients tested positive and 28 negative. (thefreelibrary.com)
  • The results of our study suggest that the information obtained by the SET method of IDT is comparable to that obtained by SPT in terms of sensitivity, specificity, and overall performance and that both SET and SPT correlate well with nasal provocation testing for ragweed. (thefreelibrary.com)
  • Among the factors that must be considered in evaluating the appropriateness of any given test are its safety (minimal risk of anaphylaxis), sensitivity, specificity positive and negative predictive values, reproducibility correlation with symptoms, and ease of administration The allergy testing modalities that are available to the clinician include in vitro testing (IVT), skin-prick testing (SPT), intradermal testing (IDT) (including skin endpoint titration [SET]), and nasal provocation testing (NPT). (thefreelibrary.com)
  • End-organ provocation of the nasal mucosa, bronchial mucosa, or conjunctivae is less commonly used in current clinical practice. (medscape.com)
  • Both BHR and bronchial obstruction at rest with subsequent expiratory flow limitation during exercise may promote respiratory symptoms during exercise in athletes. (biomedsearch.com)
  • Thereafter surveillance should be performed for the early identification of symptoms, including occupational rhinitis, with additional functional and immunological tests where appropriate. (bmj.com)
  • This testing provides an objective assessment of exercise and related symptoms. (somc.org)
  • This is open to error since the correlation between exercise related symptoms and subsequent exercise testing has been shown to be poor. (bmj.com)
  • 6 Limited access to specific exercise testing facilities means that in general clinical practice, most diagnoses are based on exercise related respiratory symptoms reported by the child or parents. (bmj.com)
  • However, several authors have shown poor correlation between self-reported exercise symptoms and the results of specific exercise testing, 7- 9 with high frequencies of false positive and false negative results. (bmj.com)
  • Patients' demographical data, course and nature of cough, accompanying symptoms and upper respiratory comorbidities, skin prick test to common aeroallergens1, baseline cough VAS (0-100 mm) 1, spirometry and induced sputum cell counts, will be recorded by the managing physician in case record file (CRF). (clinicaltrials.gov)
  • Day 294 Revisit: Patients' nature of cough, accompanying symptoms, cough VAS, spirometry, bronchial provocation test, induced sputum cell count will be reevaluated and recorded in CRF. (clinicaltrials.gov)
  • BACKGROUND: Whereas a high prevalence of bronchial abnormalities has been reported in endurance athletes, its underlying mechanisms and consequences during exercise are still unclear. (biomedsearch.com)
  • Our pulmonary function and exercise lab acts as the testing lab for many UCDHS sponsored clinical research studies for new medications and treatments for lung disease and other chronic disorders. (ucdavis.edu)
  • The two types of Provocative tests are direct and indirect. (medscape.com)
  • This testing provides metabolic measurements using indirect calorimetry for determination of oxygen consumption, carbon dioxide production, respiratory quotient and resting energy expenditure as an aid to patient nutritional assessment and management, assessment of weaning success and outcome. (somc.org)
  • The bronchoprovocation test showed an early asthmatic response to oilseed rape dust extract. (nih.gov)
  • ELISA inhibition test showed significant inhibitions with addition of oilseed rape antigen. (nih.gov)