Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.DNA, Neoplasm: DNA present in neoplastic tissue.Lung Neoplasms: Tumors or cancer of the LUNG.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Liver Neoplasms: Tumors or cancer of the LIVER.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Eye Neoplasms: Tumors or cancer of the EYE.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Nose Neoplasms: Tumors or cancer of the NOSE.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Neoplasms, Muscle Tissue: Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Adenoma: A benign epithelial tumor with a glandular organization.Dihematoporphyrin Ether: The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Bronchial DiseasesCarcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Bronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Virus Diseases: A general term for diseases produced by viruses.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions. (1/530)

Lung cancer results from a stepwise accumulation of genetic and molecular abnormalities with unknown temporal relationships to precursor bronchial lesions. In a search for biomarkers of malignant progression, we analyzed the expression of the tumor suppressor gene Rb and of the proteins regulating its phosphorylation and function in G1 arrest, p16INK4A and cyclin D1, in preinvasive bronchial lesions accompanying cancer in 75 patients, in comparison with similar lesions in 22 patients with no cancer history. Rb was constantly expressed in preinvasive lesions, including carcinoma in situ (CIS). In contrast, p16 expression was lost in moderate dysplasia (12%) and in CIS (30%) in patients with lung cancer. p16 loss occurred exclusively in patients who displayed loss of p16 expression in their related invasive carcinoma. Loss of p16 expression was not seen in nine patients with dysplasia but no cancer progression. Cyclin D1 overexpression was seen in hyperplasia and metaplasia (6%), mild dysplasia (17%), moderate dysplasia (46%), and CIS (38%) in patients with cancer but was lost in 5% of the patients during the process of invasion; it was also observed in patients with no cancer progression (14%). Our results indicate that Rb protein function can be invalidated before invasion through alteration of the Rb phosphorylation pathway, by p16 inhibition, and/or by cyclin D1 overexpression and suggest a role for p16 and cyclin D1 deregulation in progression of preinvasive bronchial lesions to invasive carcinoma.  (+info)

Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids. (2/530)

Using an in vitro lung carcinogenesis model consisting of normal, premalignant, and malignant human bronchial epithelial (HBE) cells, we analyzed the growth inhibitory effects of 26 novel synthetic retinoic acid receptor (RAR)- and retinoid X receptor (RXR)-selective retinoids. RAR-selective retinoids such as CD271, CD437, CD2325, and SR11364 showed potent activity in inhibiting the growth of either normal or premalignant and malignant HBE cells (IC50s mostly <1 microM) and were much more potent than RXR-selective retinoids. Nonetheless, the combination of RAR- and RXR-selective retinoids exhibited additive effects in HBE cells. As the HBE cells became progressively more malignant, they exhibited decreased or lost sensitivity to many retinoids. The activity of the RAR-selective retinoids, with the exception of the most potent retinoid, CD437, could be suppressed by an RAR panantagonist. These results suggest that: (a) RAR/RXR heterodimers play an important role in mediating the growth inhibitory effects of most retinoids in HBE cells; (b) CD437 may act through an RAR-independent pathway; (c) some of the RAR-selective retinoids may have the potential to be used in the clinic as chemopreventive and chemotherapeutic agents for lung cancer; and (d) early stages of lung carcinogenesis may be responsive targets for chemoprevention by retinoids, as opposed to later stages.  (+info)

Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. (3/530)

BACKGROUND: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not reduce the occurrence of primary aerodigestive tract cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results are poorly defined. Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism. In this study, we have investigated this proteolysis as a common signal used by carotenoids or receptor-selective and receptor-nonselective retinoids. METHODS: We treated cultured normal human bronchial epithelial cells, immortalized human bronchial epithelial cells (BEAS-2B), and transformed human bronchial epithelial cells (BEAS-2BNNK) with receptor-selective or receptor-nonselective retinoids or with carotenoids and studied the effects on cell proliferation by means of tritiated thymidine incorporation and on cyclin D1 expression by means of immunoblot analysis. We also examined whether calpain inhibitor I, an inhibitor of the 26S proteasome degradation pathway, affected the decline (i.e., proteolysis) of cyclin D1. RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells. Retinoids that activated retinoic acid receptor beta or retinoid X receptor pathways preferentially led to a decrease in the amount of cyclin D1 protein and a corresponding decline in growth. The retinoid-mediated degradation of cyclin D1 was blocked by cotreatment with calpain inhibitor I. CONCLUSIONS: Retinoid-dependent cyclin D1 proteolysis is a common chemoprevention signal in normal and neoplastic human bronchial epithelial cells. In contrast, carotenoids did not affect cyclin D1 expression. Thus, the degradation of cyclin D1 is a candidate intermediate marker for effective retinoid-mediated cancer chemoprevention in the aerodigestive tract.  (+info)

Survey of outpatient sputum cytology: influence of written instructions on sample quality and who benefits from investigation. (4/530)

OBJECTIVES: To evaluated quality of outpatient sputum cytology and whether written instructions to patients improve sample quality and to identify variables that predict satisfactory samples. DESIGN: Prospective randomised study. SETTING: Outpatient department of a district general hospital. PATIENTS: 224 patients recruited over 18 months whenever their clinicians requested sputum cytology, randomized to receive oral or oral and written advice. INTERVENTIONS: Oral advice from nurse on producing a sputum sample (114 patients); oral advice plus written instructions (110). MAIN MEASURES: Percentages of satisfactory sputum samples and of patients who produced more than one satisfactory sample; clinical or radiological features identified from subsequent review of patients' notes and radiographs associated with satisfactory samples; final diagnosis of bronchial cancer. RESULTS: 588 sputum samples were requested and 477 received. Patients in the group receiving additional written instructions produced 75(34%) satisfactory samples and 43(39%) of them one or more sets of satisfactory samples. Corresponding figures for the group receiving only oral advice (80(31%) and 46(40%) respectively)were not significantly different. Logistic regression showed that radiological evidence of collapse or consolidation (p<0.01) and hilar mass (p<0.05) were significant predictors of the production of satisfactory samples. Sputum cytology confirmed the diagnosis in only 9(17%) patients with bronchial carcinoma. CONCLUSIONS: The quality of outpatients' sputum samples was poor and was not improved by written instructions. Sputum cytology should be limited to patients with probable bronchial cancer unsuitable for surgery. IMPLICATIONS: Collection of samples and requests for sputum cytology should be reviewed in other hospitals.  (+info)

Sex-related differences in bronchial epithelial changes associated with tobacco smoking. (5/530)

BACKGROUND: Lung cancer is the most common cause of cancer death in North American women. Because smoking-related changes in the bronchial epithelium and in lung function have not been studied in detail in women, we used fluorescence bronchoscopy-directed biopsy to determine the prevalence of high-grade preinvasive lesions in former and current smokers of both sexes. METHODS: Spirometry, white-light bronchoscopy, and fluorescence bronchoscopy were performed in 189 women and 212 men older than 40 years of age who had smoked 20 pack-years or more (pack-years = number of packs of cigarettes smoked per day x number of years of smoking). RESULTS: Carcinoma in situ was found in 1.8% of the subjects, severe dysplasia was found in 6.5%, and moderate dysplasia was found in 14% (all preinvasive lesions). Compared with men, women had a lower prevalence of high-grade preinvasive lesions in the observed airways (14% versus 31%; odds ratio = 0.18; 95% confidence interval = 0.04-0.88), and women with preinvasive lesions had fewer such lesions (two-sided P = .048). The prevalence of preinvasive lesions did not change substantially for more than 10 years after cessation of smoking. Lung function was associated with the prevalence of preinvasive lesions, but the association was weaker in women than in men. If the presence of airflow obstruction was defined by an FEV1/FVC (forced expiratory volume in 1 second/forced vital capacity) value of 70% or less, only 56% of the men and 44% of the women with preinvasive lesions had abnormal lung function. CONCLUSION: In developing strategies for chemoprevention or early detection of lung cancer in high-risk populations, it is important to consider the effect of sex and arbitrarily chosen lung function values on the prevalence of preinvasive airway lesions.  (+info)

Malignant tumors of the liver and lungs in an area with a PVC industry. (6/530)

The incidence of malignant tumors of the lung and bronchus and of cytologically confirmed primary malignant tumor of the liver was analyzed for a 4-yr period in a city with several factories, including a PVC industry. Prior to the study two cases of angio-sarcoma of the liver were diagnosed in workers employed in PVC production. The total incidence of analyzed tumors was only slightly higher than predicted. The tumors of the liver recorded did not show any dependence on place of work or residence. During the period of observation, malignant tumors of the bronchus (lung) were not recorded in the PVC industry. Their rate in the area in which the PVC industry is situated was approximately the same as that for the entire city area. The study does not indicate that the occurrence of malignant tumors other than angiosarcoma is associated with exposure to vinyl chloride.  (+info)

Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. (7/530)

Increased protein expression of the G1 cyclins D1 and E is reported in invasive non-small cell lung carcinoma. However, during transformation of the bronchial epithelium, overexpression of these species occurs, and their relationship to aberrant expression of p53 and retinoblastoma (Rb) has not been described previously. To determine the expression of these cell cycle regulators during the development of invasive squamous cell carcinoma (SCC) of the lung, the immunohistochemical expression patterns in normal bronchial epithelium (n = 36), squamous metaplasia (SM; n = 28), and epithelial atypia (n = 34) were compared with that in low-grade dysplasia (LGD; n = 17), high-grade bronchial dysplasia (HGD; n = 30), and SCC (n = 36). Monoclonal anti-p53 Pab1801, polyclonal anti-cyclin D1 DCS6, monoclonal anti-cyclin E HE12, and monoclonal anti-Rb OP-66 antibodies were used. Cyclin D1 was not expressed in normal bronchial epithelium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs. Cyclin E was not detected in normal epithelium (n = 24), SM (n = 16), or LGD (n = 12), but it was found in 9% of atypias (2 of 22), 33% of HGDs (7 of 21), and 54% of SCCs (13 of 24). p53 was not expressed in normal epithelium, SM, and LGD, but it was overexpressed in 6% of atypias, 53% of HGDs, and 61% of SCCs. Abnormal Rb expression was found only in 2 of 36 cases of SCC. A total of 91% of HGDs and 92% of SCCs exhibited overexpression of at least one of the p53, cyclin D1, or cyclin E species. However, no link was observed between overexpression of p53 and the overexpressed G1 cyclins in preneoplastic lesions. Overexpression of cyclin D1, cyclin E, and p53 occurs frequently and independently in pulmonary SCC and is detected in lesions before the development of invasive carcinoma. In contrast, altered Rb expression is a late and infrequent event in squamous cell carcinogenesis.  (+info)

Bronchial capillary hemangioma in adults. (8/530)

Two cases with capillary hemangioma of the trachea and the left upper lobe bronchus are presented. The adult patients were referred to the hospital because of hemoptysis and cough. The chest radiographs were normal in both cases. The bronchoscopic examination revealed circumscribed lesions with a capillarized surface protruding into the lumen of the trachea and the left upper lobe bronchus, respectively. The lesions were excised in toto with flexible bronchoscopic forceps. The specimens contained typical capillary hemangiomas without any signs of malignancy. Capillary hemangioma in the bronchial tree is an extremely rare benign lesion in adults. Nevertheless, it should be considered as a possible cause of hemoptysis and cough.  (+info)

Endobronchial tumors cannot be visualized on standard two-view chest radiographs. The tumor is often associated with other phenomena, such as postobstructive pneumonia, atelectasis, and adenopathy. Chest CT scans may demonstrate a mass or adenopathy. In the present case, no mediastinal or hilar adenopathies were noted.6,7 Although there is a better chance of visualizing an endobronchial tumor by means of a CT scan than by means of a standard radiograph, endobronchial tumors can remain elusive on CT scans.1,7 Three-dimensional computer reconstruction (eg, virtual bronchoscopy) may be helpful in visualizing elusive tumors before invasive imaging becomes necessary. Virtual bronchoscopy uses CT images and various computer graphic systems to create a computerized graphic image of the endobronchial tree.8,9 The role of virtual bronchoscopy has yet to be fully defined with data to support its use in diagnosing endobronchial lesions.8,9 The preferable method for diagnosing an endobronchial tumor is ...
Shorthouse, A J.; Smyth, J F.; Peckham, M J.; and Steel, G G., "Comparison of the chemosensitivity of bronchial carcinoma xenografts with donor patients. Abstr." (1980). Subject Strain Bibliography 1980. 1141 ...
Learn about the causes, symptoms, diagnosis & treatment of Tumors of the Lungs from the Professional Version of the Merck Manuals.
We have previously demonstrated that vascular count significantly increases in the preneoplastic lesions of the bronchial tree, starting from very low levels in the normal epithelium to a significantly higher number of microvessels in moderate dysplastic lesions and in situ carcinomas. Vascular endothelial growth factor (VEGF) protein expression has shown to be strictly associated with neovascularization both in human cancer and in various type of preinvasive lesions. A number of studies have demonstrated that mutant p53 is involved in the regulation of angiogenesis, and immunohistochemical detection of the p53 protein is associated with p53 gene mutations. In this study we looked for possible correlation between p53 protein detection, VEGF expression and vascular count in a series of preneoplastic and neoplastic lesions of the bronchial tree in order to investigate the angiogenic pattern and its genetic control in the early steps of bronchial cancer development. Twenty-four retrospective ...
Looking for endobronchial tube? Find out information about endobronchial tube. in electronics: see electron tube electron tube, device consisting of a sealed enclosure in which electrons flow between electrodes separated either by a... Explanation of endobronchial tube
Bronchial carcinoid tumors are very rare pulmonary neoplasms. They usually present with pulmonary symptoms or paraneoplastic syndromes. Typical (well-differentiated) tumors are usually indolent with survival exceeding 90% after resection. Atypical carcinoids have a worse prognosis. They are much more likely to recur locally or to have distant metastases. This case report describes a patient who presented with abdominal pain and hepatic lesions who was subsequently diagnosed to have bronchial carcinoid.
Endobronchial lipomas, usually found in the obese and in smokers, can cause patients significant distress with chronic cough, chest pain, dyspnea, and increased infection risk.
Etiology of bronchial obstruction: a) spasm; b) mucous odema; c) hypersecretion; d) scar narrowing: e) endobronchial tumor; f) external pressuring of bronchus. Surgical procedure is typically useful for COPD in chosen cases. A bullectomy is the surgical elimination of a bulla, a large air-stuffed space that can squash the encircling, more normal lung. Lung volume reduction surgery is similar; parts of the lung which might be significantly broken by emphysema are eliminated permitting the remaining, relatively good lung to increase and work better. Lung transplantation is sometimes carried out for extreme COPD, significantly in youthful people.. G-BBDG first flew in 1974 and was thought-about to be a pre-manufacturing model used to finalise the Concorde design earlier than the opposite plane entered passenger service. This aircraft was painted in BA livery throughout the assessments and spent a complete of 1282hrs in the air. The final flight was in 1981 and the … Read More ...
The pure distal left main bronchial sleeve resection with total lung parenchymal preservation: report of two cases and literature review
OBJECTIVES: I. Determine the efficacy of inhaled budesonide on the number and grade of bronchial epithelial dysplastic lesions in former and current smokers. II. Compare the effect of inhaled budesonide vs placebo in modulating several intermediate biomarkers (i.e., proliferation, apoptosis, morphometric, and methylation markers) in this patient population. III. Correlate the regression of bronchial dysplasia (number and grade) and improvement in sputum cytology (morphometric grade of atypical cells) with the modulations in molecular biomarkers in this patient population. IV. Compare the stability of the chemopreventive effect of these treatment regimens at six months after completion of these regimens in these patients. V. Compare the safety of these treatment regimens in these patients.. OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are stratified according to gender, smoking status (current vs former), and morphometric index (no greater than 3.4 vs greater ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cause Meaning * Bronchial Cancer * Bronchiectasis * Chronic Lung Disease * Emphysema * Lung Cancer * Lung Disease * Mesothelioma * Waldenstroms Macroglobulinemia
Actions on H.R.559 - 105th Congress (1997-1998): To amend title 38, United States Code, to add bronchiolo-alveolar carcinoma to the list of diseases presumed to be service-connected for certain radiation-exposed veterans.
Eloise Mikkonen from the University of Tampere, Finland, is part of a collaborative project investigating a connection between herpes simplex virus and Alzheimers disease. Thanks to a Travelling Fellowship from DMM, she visited her collaborators in Umeå University, Sweden, and the team have now published their work in DMM. Read more on her story here.. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 23 February 2018. Apply now!. Did you know that DMM also offers conference travel grants? Apply by 9 March 2018. Find out more here.. ...
We submit the case of a child afflicted with a mucoepidermoid bronchial tumor. The patient is a boy, aged seven, who after undergoing antibiotic treatment for six weeks because of a fever and atelectasia-condensation in the right lower lobe showed no signs of clinical improvement and was sent to our department to undergo further study and treatment. A bronchoscopy performed shows a polypoid mass that partially blocks the main bronchial tube a few milimiters under the access to the right upper lobe. A biopsy is carried out and the anatomopathological test shows there is a low degree epidermoid carcinoma ...
METHODS: All bronchoscopies performed for suspected bronchial carcinoma at Papworth Hospital, Cambridge, United Kingdom, over the last 3 years were reviewed retrospectively. Patients with peribronchial disease, as evidenced by submucosal infiltration or extrinsic compression on bronchoscopy, were selected for TBNA. Patients with computed tomography evidence of subcarinal lymphadenopathy were also included. In total we identified 78 patients: 67 with peribronchial disease and 21 with subcarinal lymphadenopathy. All 78 patients underwent TBNA, and in 8 of these TBNA was performed in 2 sites. ...
Synonyms for bronchus in Free Thesaurus. Antonyms for bronchus. 1 synonym for bronchus: bronchial tube. What are synonyms for bronchus?
Subcutaneous octreotide treatment of a growth hormone-releasing hormone-secreting bronchial carcinoid: superiority of continuous versus intermittent administration to control hormonal secretion ...
Endobronchial lipomas are rare benign tumors which are amenable to endoscopic management both for diagnosis and treatment. Excluding those cases that merits surgical treatment, endoscopic mechanical debulking in conjunction with other techniques actually are the preferred method of treatment as it results in complete resection and preserve lung parenchyma.1 These tumors are poorly vascularized and patients rarely present with hemoptysis, and if that is the case, it has been mainly attributed to post obstructive pneumonia or bronchiectasis rather than the tumor itself.2 With all of this in mind, we recently decided to resect a previously histologically confirmed endobronchial pedunculated lipoma which obstructs the intermediary bronchus (Fig. 1A) from a 69-year old never smoker man who has a history of recurrent right lower pneumonia and with the aid of a cold snare device (Fig. 1B) intended for percutaneous endoscopic gastrostomy (Cook Medical). In a similar way as described by other authors ...
TY - JOUR. T1 - Natural history of bronchial preinvasive lesions. AU - Ishizumi, Taichiro. AU - McWilliams, Annette. AU - MacAulay, Calum. AU - Gazdar, Adi. AU - Lam, Stephen. PY - 2010/3. Y1 - 2010/3. N2 - Preinvasive bronchial lesions defined as dysplasia and carcinoma in situ (CIS) have been considered as precursors of squamous cell carcinoma of the lung. The risk and rate of progression of preinvasive lesions to invasive squamous cell carcinoma as well as the mechanism of progression or regression are incompletely understood. While the evidence for the multistage, stepwise progression model is weak with relatively few documented lesions that progress through various grades of dysplasia to CIS and then to invasive carcinoma, the concept of field carcinogenesis is strongly supported. The presence of high-grade dysplasia or CIS is a risk marker for lung cancer both in the central airways and peripheral lung. Genetic alterations such as loss of heterozygosity in chromosome 3p or chromosomal ...
Tracheobronchial foreign body (TFB) aspiration is a common occurrence in children compared with adults. Long-standing cases of TFB aspiration during childhood presenting in an adult have rarely been reported. We report the unique case of an endobronchial Playmobil traffic cone that went undetected for 40 years and presented as a suspected bronchogenic carcinoma. This was subsequently removed successfully with flexible bronchoscopy. To our knowledge this is the first case of a TFB that was overlooked this length of time. ...
Purpose: To assess various volume based PET quantification metrics including: metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with different thresholds as well as background activity based PET metrics (Background Subtracted Lesion activity (BSL) and Volume (BSV)) as prognostic markers for progression free and overall survival (PFS, OS) in early stage I and II non-small cell lung cancer (NSCLC) after resection. Patients and Methods: 133 patients received an adequate FDG PET/CT scan prior to surgery between January 2003 and December 2010. All PET activity metrics showed a skewed distribution and were log-transformed before calculating the Pearson correlation coefficients (PCC). Survival tree analysis was used to discriminate between high and low risk patients and to select the most important prognostic markers. Akaike information criterion (AIC) was used to compare two uni-variate models. Results: Within the study time 36 patients died from NSCLC and 26 patients from other causes. ...
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008 ...
Endobronchial lipomas are rare benign tumours that cause bronchial obstruction, leading to extensive distal parenchymal damage. This report describes the endoscopic removal of a right main bronchus lipoma with a rigid endoscope and snare technique in
TY - JOUR. T1 - Influence of a dexamethasone-eluting covered stent on tissue reaction. T2 - An experimental study in a canine bronchial model. AU - Shin, Ji Hoon. AU - Song, Ho Young. AU - Seo, Tae Seok. AU - Yuk, Soon Hong. AU - Kim, Young Hwa. AU - Cho, Yong Mee. AU - Choi, Gi Bok. AU - Kim, Tae Hyung. AU - Suh, Ji Yeon. PY - 2005/6. Y1 - 2005/6. N2 - This study was designed to evaluate the feasibility and efficacy of a dexamethasone (DXM)-eluting, covered, self-expanding metallic stent to reduce tissue reaction following stent placement in a canine bronchial model. We placed a DXM-eluting, polyurethane-covered, self-expanding metallic stent (drug stent, DS) and a polyurethane-covered, self-expanding metallic stent (control stent, CS) alternately in each left main bronchus and left lower lobe bronchus in 12 dogs. The stents were 20 mm in diameter and length when fully expanded. The dose of DXM was approximately 36.7 mg in each DS, but was absent in the CS. The dogs were euthanased 1 week ...
The third case of a culturally and histologically proven candidosis of the prostate in the world literature available to us is reported. Autopsy of a 59-year-old man with metastasizing bronchial carcinoma as predisposing primary disease revealed a local candidosis of the prostate in the left lobe of the prostate, without evidence of a Candida sepsis. Parallel and different aspects in comparison with the other two cases are described.
Free, official information about 2008 (and also 2009-2015) ICD-9-CM diagnosis code 162.3, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
Trachea R. cranial lobar bronchus. R. middle lobar bronchus R. caudal lobar bronchus R. accessory lobar bronchus L. cranial lobar bronchus. L. caudal lobar bronchus. Return to Gross Anatomy
Endobronchial cancer are characterized by small size, slow growth and usually misdiagnosed as asthma or chronic bronchitis due to their common symptoms.This research report analyzes this market on the basis of its market segments, major geographies, and current market trends.
For operable patients with NSCLC in whom tumour growth is limited to one lobe, lobectomy is the treatment of choice. Intentionally curative radiotherapy is a good alternative if the surgical risk is determined to be (too) high.. Patients in whom lung function is so limited that lobectomy is not possible may be considered for segment resection (preferred) or wedge excision if complete resection using this method is possible.. In principle, if the lung tumour has spread from one lobe to another, a lobectomy plus a wedge resection of the other lobe should be performed. For central tumours, bilobectomy or pneumonectomy may be an option.. If a conventional lobectomy is not possible due to tumour growth up to or past the level of the bronchial ostium, a sleeve lobectomy is advisable because complete resection is possible with this technique even when lung function precludes pneumonectomy.. A sleeve resection of the pulmonary artery should be performed only if the patient cannot tolerate pneumonectomy ...
Khoo, K.L., Lee, P., Mehta, A.C. (2013-05-15). Endobronchial epinephrine: Confusion is in the air. American Journal of Respiratory and Critical Care Medicine 187 (10) : 1137-1138. [email protected] Repository. https://doi.org/10.1164/rccm.201209- ...
Medical information, Adenocarcinoma of the bronchus. Definition of Adenocarcinoma of the bronchus, symptoms of Adenocarcinoma of the bronchus, treatment of Adenocarcinoma of the bronchus, and prevention of Adenocarcinoma of the bronchus. Exams and Tests Adenocarcinoma of the bronchus.
CASE SUMMARY A 16-year-old girl presented with a 6-month history of intermittent dry cough. For the 2 weeks prior to hospitalization, the patient had tactile...
CASE SUMMARY A 16-year-old girl presented with a 6-month history of intermittent dry cough. For the 2 weeks prior to hospitalization, the patient had tactile...
Another name for Adenocarcinoma of the Bronchus is Adenocarcinoma of the Bronchus. What is adenocarcinoma of the bronchus? A person with adenocarcinoma ...
ICD-10 C34.31 is malignant neoplasm of lower lobe, right bronchus or lung (C3431). This code is grouped under diagnosis codes for neoplasms.
Bronchi help transport air to and from the lungs; they send oxygen to the lungs and allow carbon dioxide to exit the lungs. The bronchi are a part of the respiratory tract that act as an extension of...
On slicing, the left lung contained a diffuse white mass with an ill-defined edge; as you can see on the image. The mass had started to occlude the main bronchus of the left lung but could not be seen to arise directly from the bronchus ...
Taxorest normalizes the function of the bronchi by reducing their peptide deficiency and restoring protein synthesis inside their cells.
The goal of this project was to realise a realistic but simplified 3D model of a human Bronchus to be used for medical engineering purposes. The model was modelled in Autodesk Maya and refined in ZBrush, where the texture work was also produced. Secondly the 3D model was adjusted to be used within Unity 3D to allow compatibility with the software used by engineers for live testing ...
Arguably the simplest way to achieve one-lung ventilation is through deliberate bronchial intubation with a standard endotracheal tube. If this is used as a blind technique, the tube is most likely to go down the right main bronchus, as the course of the right main bronchus is more in line with the trachea than the course of the left, which comes off at the carina at a bigger angle.. [drawing]. This technique has several drawbacks: When a standard ETT is used to intubate the right main bronchus, the tube cuff is very likely to occlude the right upper lobe bronchus. So in addition to isolating the left lung this technique can inadvertently also isolate a significant part of the right lung. A second disadvantage is that left main bronchus intubation is not reliably achieved when this technique is used blindly. A fiberoptic scope is therefore frequently necessary to place a tube into the left main bronchus.. ...
Progress in the field of fluorescence bronchoscopy has made it possible to locally diagnose bronchial dysplasia, thought sometimes to be the precancerous lesions of squamous cell carcinoma. We have recently reported the results of extensive studies of dysplasia in bronchial mucosa using white light bronchoscopy combined with fluorescence bronchoscopy.3 However, it proved impossible, even with a BF240 bronchovideoscope, to obtain findings other than swelling and redness in bronchial bifurcations, as previously reported.12,13 Because of the difficulty in diagnosing dysplasia by white light bronchoscopy, we attempted to obtain detailed white light observations of bronchial dysplasia using a direct viewing high magnification bronchovideoscope with the aim of developing a new method of bronchoscopic diagnosis.. In gastrointestinal endoscopy, high magnification endoscopy has been developed for observing and analysing epithelial microstructures. Moreover, there have been several recent reports on the ...
A 15-year-old boy presented to us with a 4-month history of fever with worsening dyspnea since 1 month. His contrast-enhanced computed tomography scan of the thorax showed bilateral endobronchial lesions with complete collapse-consolidation of the left lung and partial collapse of the right lower lobe. His fiberoptic bronchoscopy guided biopsy had been reported in outside hospital as a neuroendocrine tumor. Due to worsening breathlessness, he had to be intubated. We repeated the endobronchial biopsy and combined with outside slides and blocks, was diagnosed to have an anaplastic lymphoma kinase-1 positive anaplastic large cell lymphoma (ALCL ...
BACKGROUND: When hormones are detected in the serum of patients with bronchial carcinoma they are generally considered to originate from the tumour, but this may be not the only explanation. Pulmonary endocrine cells proliferate in lungs affected by non-neoplastic disease and their products are often demonstrable in the serum. The aim of this study was to examine the pulmonary endocrine systems of a series of tumour-bearing lungs to see whether any changes in them could possibly account for raised levels of pulmonary peptides in the blood. METHODS: The morphology, number, distribution, and content of pulmonary endocrine cells in 30 pairs of tumour-bearing lungs from patients coming to necropsy with bronchial carcinoma were examined. These features were related to the pathology of the tumour and to other pathological changes present in the lungs, and compared with pulmonary endocrine cells in 10 pairs of control lungs from patients without pulmonary disease. RESULTS: Increased numbers of ...
Sampling techniques are combined during bronchoscopy to increase the diagnostic yield for endobronchial malignant tumours. Bronchial biopsy provides the definitive histological diagnosis in most cases, but accompanying cytological procedures such as washing, brushing, needle aspiration or imprint cytology can increase diagnostic yield. In this prospective study, a different cytological technique, that could enhance the diagnostic yield of bronchoscopy without increasing its time or cost, was tested. Flexible bronchoscopy was performed in 93 patients suspected of having pulmonary neoplasms. Bronchial biopsies were initially placed in a balanced salt solution. When bronchoscopy was finished, all visible tissue fragments were removed and placed in formalin to undergo histopathological examination and the rinse fluid was sent for cytological examination. Washing was performed routinely but no cytological brushing was employed. Eighty-two patients had final diagnoses of malignant neoplasm. In four ...
Introduction:. Flexible bronchoscopy has a important role in diagnosing lung cancer. Where tumor is visible on bronchoscopy, it is common practice to carry out the full complement of Forceps biopsies, washings and brushings to enable histological/cytological diagnosis1, 2.. The aim of this retrospective study was to determine whether routine collection of cytology samples (washings & brushings) increase the diagnostic yield as compared to biopsy alone in cases where adequate biopsies (at least five) of bronchoscopically visible tumor were obtained.. Method:. We reviewed consecutive series of 278 bronchoscopies in which biopsies were done during period of 5 years from 2008 to 2012. A total of 148 bronchoscopies met the criteria of bronchoscopically visible tumor and in 145 of these the bronchoscopist felt adequate biopsies were obtained. All these patients also had washings and brushings carried out.. Results:. In the 145 cases where adequate biopsies were obtained, overall diagnostic yield was ...
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. ...
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of Polyphenon E, a substance found in green tea, may keep ca
Endobronchial brachytherapy in the treatment of malignant lung tumours.: A prospective study was made to assess the short-term clinical and endoscopic response
... , also known as tracheobronchial prostheses, are tube-shaped devices that are inserted into an airway. They are usually placed bronchoscopically and can be used to treat a variety of large airway diseases. The indications for airway sten
Right middle lobar bronchus aka Bronchus lobaris medius dexter in the latin terminology and part of structures of the trachea and the bronchi seen from the anterior and posterior views. Learn more now!
Lungs, Bronchi, Trachea, NoseAnatomy and PhysiologyThe Respitory SystemLungs, Bronchi, Trachea, NosePharynxMore Than Just a PipeGas Laws and BreathingVolumes and Volumes I know, I know, breathing always makes you think about lungs, but how does the air in the lungs get there?
Bronchus: …the smooth muscle surrounding the bronchi, swelling and inflammation of the bronchial tubes, and excessive secretion of mucus into the airways. The inflamed, mucus-clogged airways act as a one-way valve-i.e., air is inspired but cannot be expired. The obstruction of airflow may resolve spontaneously or with treatment.
The trachea (windpipe) divides into two main bronchi (also mainstem bronchi), the left and the right, at the level of the sternal angle. The right main bronchus is wider, shorter, and more vertical than the left main bronchus. The right main bronchus subdivides into three segmental bronchi while the left main bronchus divides into two. The lobar bronchi divide into tertiary bronchi. Each of the segmental bronchi supplies a bronchopulmonary segment. A bronchopulmonary segment is a division of a lung that is separated from the rest of the lung by a connective tissue septum. This property allows a bronchopulmonary segment to be surgically removed without affecting other segments. There are ten segments per lung, but due to anatomic development, several segmental bronchi in the left lung fuse, giving rise to eight. The segmental bronchi divide into many primary bronchioles which divide into terminal bronchioles, each of which then gives rise to several respiratory bronchioles, which go on to divide ...
Giant fibroepithelial polyp is a rare mesenchymal tumour of the vulva, which although benign, mimics a malignant neoplasm. We report a case of giant fibroepithelial polyp of vulva that was...
Looking for online definition of endobronchial biopsy in the Medical Dictionary? endobronchial biopsy explanation free. What is endobronchial biopsy? Meaning of endobronchial biopsy medical term. What does endobronchial biopsy mean?
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Ernst Wynder was one of the outstanding entrepreneurs of modern American medicine. I became involved with him in the mid-1970s, not long after he organized the American Health Foundation, a non-profit research and public health enterprise in New York City. We were first thrown together on the Steering Committee of MRFIT, in which trial he and Peter Peacock and Charles Arnold directed the New York City unit.. Wynders academic credentials dated from a pioneering 1951 publication with surgeon Ewarts Graham in St. Louis, a case-control study of cigarette smoking and death from bronchial carcinoma. They documented what Graham and Ocshner, leading chest surgeons of the day, were observing clinically and preaching to any and all who would listen: squamous-cell carcinoma of the bronchus occurred almost exclusively among heavy cigarette smokers. The Wynder-Graham clinical-epidemiologic demonstration, methodologically advanced for its day, was acknowledged by all in the field but never by any of the ...
Background & Aim: The prevalence of obesity in adolescents and young patients is steadily increasing and bariatric surgery has become a standard treatment for ...
Right main bronchus is wider and deviates less from the axis of the trachea (the left main bronchus has a tighter turn over the heart), which is why foreign bodies will tend to the right ...
Finally, my latest Mystery has been solved! You may recall that the latest in a series of Mystery problems (all deserving of capital Ms) has been a chronic cough along with shortness of breath. My inability to talk very long without lapsing into a coughing fit began before Christmas. Scans, tests, medications and inhalers didnt help, and this current episode of my version of House was finally solved this week. It turns out that I have an endobronchial lesion in one of the main airways in my right lung. I learned that this is a rare condition (no surprise there). This was found when I had a bronchoscopy as a last resort. Upon waking up from this incredibly uncomfortable test, my doctor told me the lesion has to come out and pointed me to an interventional pulmonologist who can remove the lesion with a laser during another bronchoscopy ...
Looking for online definition of eparterial bronchus in the Medical Dictionary? eparterial bronchus explanation free. What is eparterial bronchus? Meaning of eparterial bronchus medical term. What does eparterial bronchus mean?
Chromosome 3 allele loss in preinvasive bronchial abnormalities and carcinogen-exposed, histologically normal bronchial epithelium indicates that it is an early, possibly the first, somatic genetic change in lung tumor development. Candidate tumor suppressor genes have been isolated from within distinct 3p regions implicated by heterozygous and homozygous allele loss. We have proposed that DUTT1, nested within homozygously deleted regions at 3p12-13, is the tumor suppressor gene that deletion-mapping and tumor suppression assays indicate is located in proximal 3p. The same gene, ROBO1 (accession number ), was independently isolated as the human homologue of the Drosophila gene, Roundabout. The gene, coding for a receptor with a domain structure of the neural-cell adhesion molecule family, is widely expressed and has been implicated in the guidance and migration of axons, myoblasts, and leukocytes in vertebrates. A deleted form of the gene, which mimics a naturally occurring, tumor-associated human
bronchoscopy - MedHelps bronchoscopy Center for Information, Symptoms, Resources, Treatments and Tools for bronchoscopy. Find bronchoscopy information, treatments for bronchoscopy and bronchoscopy symptoms.
Bronchial emphysema, bronchial atresia surgery, bronchial epithelium and smoking, bronchial congestion lungs and pediatric bronchial pneumonia treatment. Bronchial tapping procedure, bronchial hyperresponsiveness asthma, how to perform bronchial tapping pediatric patients and bronchial walls or bronchial dysplasia symptoms.
Carcinoid tumors are rare cancerous tumors that are difficult to treat but, if detected early enough, can be cured. These tumors usually begin in the lungs or digestive tract lining. Ideally, they...
Lung bronchus cross-section, coloured scanning electron micrograph (SEM). This longitudinal freeze-fracture has exposed the inner epithelial surface of a bronchus (pink). The different ciliated and secretory cells are just visible. The bronchus is surrounded by pale pink lung tissue consisting mainly of alveolar elements (alveoli). Two blood vessels (orange lumens) are at upper left and top right. Magnification: x150 when printed at 10 centimetres across. - Stock Image C004/7743
Most people are awake during this procedure. You will have medicine to help you relax and to numb your throat. The bronchoscopy itself usually takes about 20 minutes.This is what usually happens during bronchoscopy:
Pekana! Bropert (previously Bronchi Pertu ) - BRONCHI-PERTU spag. syrup (pronounced bronkee-PAIR-too) For treatment of bronchial infections, asthma and whooping cough Name: BRONCHI(tis) PERTU(ssis) INDICATIONS BRONCHI-PERTU syrup is indicated for bronchitis, asthma, whooping cough and other infections of the breathing passageways. Istimulates excretion of toxins that cause symptoms such as a dry cough with stabbing pains and
The best selection of royalty free bronchus vector images, graphics and stock illustrations. Download 8+ bronchus vector images in EPS and JPG format.
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What is Carcinoid Cancer? Get the facts about Carcinoid Cancer symptoms, testing, treatment and care options from trusted sources.
Cats may acquire one or more conditions that cause the bronchi to become inflamed and hypersensitive to irritants, conditions which can narrow the airways to the point of making it difficult for the cat to breathe. - Wag! (formerly Vetary)
Expression of CA13 (CAXIII, FLJ37995, MGC59868) in bronchus tissue. Antibody staining with HPA024689 and CAB025567 in immunohistochemistry.
Expression of ZNF26 (FLJ20755, KOX20) in bronchus tissue. Antibody staining with HPA018329 and HPA042406 in immunohistochemistry.
Learn about why your doctor would order a bronchoscopy, what the procedure is like, and what results and complications you might experience.
This morning I had my bronchoscopy, which is required for the study Im enrolled in. This was not very fun at all. I could handle it, I always do. Now it...
Looking for information on Atelectasis? Medigest has all you need to know about Atelectasis - Symptoms and Signs, Causes, Treatments and definition
hyparterial definition: Situated below an artery; applied especially into the branches of this bronchi offered down underneath the point where in fact the pulmonary artery crosses the bronchus.; Situated…
Πνευμονολόγος Θεόδωρος Ι. Βασιλακόπουλος - Καθηγητής Πνευμονολογίας και Εντατικής Θεραπείας Ιατρικής Σχολής Πανεπιστημίου Αθηνών ΓΝΑ Ευαγγελισμός
Though carcinoids are slow growing tumors, which can be treated by surgery, the survival in metastatic carcinoids is very low because the treatment strategies for other cancers are not effective for dealing with advanced stage carcinoids [36]. Therefore, the investigations concerning the discovery of new strategies for treating pulmonary carcinoids need to be focused on therapies that can inhibit the growth and invasiveness of advanced stage disease. Carcinoid tumors are proving moderately responsive to newer therapies targeting tumor vasculature and survival pathways [1, 2]. The mammalian target of rapamycin (mTOR) inhibitor, everolimus, has shown promising initial results alone or combined with other agents [37-39]. Bronchial AC, which is characterized by high mTOR expression, has been reported to be responders to mTOR inhibition, indicating that therapies targeting the critical survival pathways are potential candidates to treat bronchial carcinoids [40]. The evidence seems to indicate that ...
Fibroepithelial polyps of the anus should not be mistaken for condylomas. They should also be distinguished from the much smaller transient infantile perianal pyramidal protrusion which occurs predominantly in young girls in the midline. Larger, fleshier, more oedematous skin tags should arouse the suspicion of Crohns disease. They can predate gastrointestinal disease by several years. Disturbance of the normal embryological development of the anus may rarely result in the appearance of one or more polypoid projections at the anus (anomalous anal papillae). These may be asymptomatic, but often become complicated by ulceration, faecal retention and constipation ...
Carcinoid tumors represent an interesting family of tumors that are derived from neuroendocrine cells. With few exceptions, carcinoid tumors comprise a tiny fraction of tumors within any specific organ (11). These tumors were first described by Langhans (12) but were not described in detail until Lubarsch (13) described them in 1888. The name karzinoide was not used until 1907 by Oberndorfer (14), and was chosen to reflect his opinion that these were benign tumors. However, these tumors have a wide range of clinical presentations and diverse outcomes from benign to malignant. In the testis and in other organs, carcinoid tumors may behave aggressively and some investigators (15) have suggested that a designation of "neuroendocrine carcinoma" is more appropriate than "carcinoid tumor"; other investigators disagree with this approach (16).. The histogenesis of testicular carcinoid tumor has been a matter of debate (17). There is a strong rationale for the concept that testicular carcinoid tumor is ...
Carcinoid tumors are rare. In early stage disease they may cause either no or few nonspecific symptoms. Therefore, patients with carcinoid tumors most often present late in the course of their illness when there is already progression to an incurable state as a result of metastatic disease. At present there are neither practical population screening tests nor effective therapies and hence the 5 year survival rate is low. Due to the rareness of sporadic carcinoid tumors, large scale genetic analysis and development of sensitive and specific diagnostic tests have not been successful. While kindreds with familial carcinoid tumors that are not ascribable to known genetic syndromes are exceedingly rare, they provide a unique opportunity to facilitate the identification of the responsible gene mutation. In addition, the mutated gene in the rare familial form may also underlie the origin of the more common sporadic occurrence of carcinoid tumors. We propose to study families in which there are at least ...
The subdivision of the lung is characterised by the branching of the bronchi: the bronchial tree. The main bronchi form the stem of the bronchial tree, which splits within the lung dichotomously. The right main bronchus is called bronchus principalis dexter, the left bronchus is called bronchus principalis sinister. The main bronchi are divided into lobar bronchi - right in three lobar bronchi: bronchi lobares superior, medius and inferior and left into the bronchi lobares superior and inferior. Thereafter, there follows further division into segmental bronchi - right 10, left 9 segmental bronchi. This is followed by subsegmental bronchi, the bronchioles and finally the bronchioli terminales. The conductive, air-transporting phase of the bronchial tree ends here. Thereafter follows the sectional formation, which serves for gas exchange and as the lung parenchyma in the narrow sense. These include the bronchioli respiratorii, the ductus alveolaris and sacculi alveolares. The respiratory ...
5.1 Exposure data. Exposure to dimethyl sulfate may occur during its manufacture and its use as a methylating agent.. 5.2 Human carcinogenicity data. No epidemiological studies were available to the Working Group. A small number of cases of, mainly, bronchial carcinoma has been reported.. 5.3 Animal carcinogenicity data. Dimethyl sulfate was tested for carcinogenicity in rats by inhalation, subcutaneous and intravenous injection, and following prenatal exposure. It produced local sarcomas and tumours of the nervous system.. 5.4 Other relevant data. Dimethyl sulfate rapidly decomposes on contact with water, as a result of which it very rapidly disappears from the circulation of dosed rats.. It is corrosive or irritant to the skin, eyes and respiratory tract of exposed people, and may result in death caused by respiratory failure.. Dimethyl sulfate is embryotoxic to rats and causes malformations among surviving foetuses.. Workers exposed to dimethyl sulfate have developed chromosomal aberrations ...
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Purpose The treatment planning (TP) in high-dose-rate (HDR) endobronchial brachytherapy (EB) can be based on various forms of imaging. In the case of lung cancer, one-dimensional or two-dimensional imaging is standard. The dose coverage of the target (planning target volume - PTV) and organs...
Endobronchial ultrasound (EBUS) is a bronchoscopic technique that uses ultrasound to visualize structures within the airway wall, lung, and mediastinum. EBUS is different from endoscopic ultrasound (EUS). While both can visualize and guide sampling o
Multiple Choice Test 1) The right middle lobe bronchus: One answer only. A. Comes off the right main bronchus 3cm belo
I am a Thoracic Surgeon. As part of my clinical activities, I perform Bronchoscopies frequently. Many times, these Bronchoscopies are performed on awake patients, making the analgesia and topical anesthesia essential. The quality and extent of the anesthesia produced by topical agents correlates completely with both the adequacy of the examination performed as well as the patients comfort and willingness to undergo a repeat procedures. I have utilized Cetacaine spray as standard and primary agents during these procedures. Ive been able to examine Bronchoscopically nearly a thousand awake patients over many years without using IV sedation whatsoever. IV sedation leaves the patients with diminished sensorium. Not using it and relying only on topical agents is truly beneficial to my patients, and is achieved primarily by Cetacaine.. ...
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4-stage cross-section of the bronchus demonstrating the tissue changes occurring in asthma and chronic bronchitis. 4-stages: normal bronchus, hypersecretion of the mucous gland, swelling with lymphoid aggregations and smooth-muscle spasm.
Pronunciation guide: Learn how to pronounce bronchi in English with native pronunciation. bronchi translation and audio pronunciation
We offer discount medical surgical supplies and instruments in the Cardiovascular Bronchus Clamps category, such as the Lees Bronchus Clamp 9 3/4 52-2382
Anderson HJ, Churchill-Davidson HC, Richardson AT (December 1953). "Bronchial neoplasm with myasthenia; prolonged apnoea after ... "Defect of neuromuscular conduction associated with malignant neoplasms". Am. J. Physiol. 187: 612-613. Gutmann L, Crosby TW, ...
... is a very rare malignant neoplasm originating from bronchial glands. It is classified as a ...
Entero-pancreatic gastrinomas and thymic and bronchial carcinoids are the leading cause of morbidity and mortality. ... "Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and ... and bronchial carcinoids also occur. The phenotype of MEN1 is broad, and over 20 different combinations of endocrine and non- ... Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, ...
Although it is not normally considered a fast-growing malignant neoplasm, FA can exhibit high uptake on FDG-PET scanning. ... October 2010). "Bronchial brushing cytology of a pulmonary fetal adenocarcinoma with a poorly differentiated component". ... While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required ... Odashiro DN, Nguyen GK (April 2006). "Pulmonary well-differentiated fetal adenocarcinoma diagnosed by bronchial brush and ...
In a pneumonectomy, in which an entire lung is removed, the remaining bronchial stump may leak air, a rare but very serious ... It may also occur with fractures of the facial bones, neoplasms, during asthma attacks, when the Heimlich maneuver is used, and ... Trauma to parts of the respiratory system other than the lungs, such as rupture of a bronchial tube, may also cause ... Air may travel upward to the neck from a pneumomediastinum that results from a bronchial rupture, or downward from a torn ...
NOS M8000/6 Neoplasm, metastatic Neoplasm, metastatic Tumor, metastatic Tumor, secondary Tumor embolus M8000/9 Neoplasm, ... cylindroid Bronchial adenoma, cylindroid (C34._) M8201/2 Cribiform carcinoma in situ (C50._) Ductal carcinoma in situ, ... benign M8000/1 Neoplasm, uncertain whether benign or malignant Neoplasm, NOS Tumor, NOS Unclassified tumor, uncertain whether ... M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant ...
Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Pleuropulmonary blastoma Laryngeal ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
On examination of the chest there will be features of consolidation such as localized dullness on percussion and bronchial ... are due to neoplasms across all age groups, higher in older people; primary squamous carcinoma of the lung is the most common. ... Presence of air-fluid levels implies rupture into the bronchial tree or rarely growth of gas forming organism. Raised ... Fiber optic bronchoscopy is often performed to exclude obstructive lesion; it also helps in bronchial drainage of pus. ...
Naib ZM (1961). "Giant cell carcinoma of the lung: cytological study of the exfoliated cells in sputa and bronchial washings". ... Spivach A, Borea B, Bertoli G, Daris G (July 1976). "[Primary lung neoplasm of rare incidence: giant cell carcinoma]". Minerva ... The new paradigm recognizes that lung cancers are a large and extremely heterogeneous family of malignant neoplasms, with over ... Travis WD (November 2010). "Sarcomatoid neoplasms of the lung and pleura". Arch. Pathol. Lab. Med. 134 (11): 1645-58. doi: ...
... s are neoplastic tumors of the lung These include: Primary tumors of the lung/pulmonary system: Bronchial leiomyoma, ... Mediastinal tumors Pleural tumors Metastasis or secondary tumors/neoplasms with other origin: Metastasis to the lung Chong S, ...
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Bronchial carcinoid can cause airway obstruction, pneumonia, pleurisy, difficulty with breathing, cough, and hemoptysis, or may ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are ...
Apart from that it is doubtful that possible prognosis for a patient suffering from bronchial asthma and chronic leukemia is ... In the comorbid structure of these patients, most frequently present are malignant neoplasms, locomotorium disorders, skin and ... Role of chronic allergic inflammation in bronchial asthma pathogenesis and its rational pharmacological therapy for patients ... Greenfield to evaluate comorbidity in patients with malignant neoplasms, later it also became useful for other categories of ...
Moro D, Brichon PY, Brambilla E, Veale D, Labat F, Brambilla C (June 1994). "Basaloid bronchial carcinoma. A histologic group ... Maleki Z (March 2011). "Diagnostic issues with cytopathologic interpretation of lung neoplasms displaying high-grade basaloid ...
... is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in ... carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial ...
... respiratory tract neoplasms MeSH C04.588.894.797.265 --- bronchial neoplasms MeSH C04.588.894.797.520 --- lung neoplasms MeSH ... nose neoplasms MeSH C04.588.149.721.656 --- orbital neoplasms MeSH C04.588.149.721.828 --- skull base neoplasms MeSH C04.588. ... anal gland neoplasms MeSH C04.588.274.476.411.445 --- duodenal neoplasms MeSH C04.588.274.476.411.501 --- ileal neoplasms MeSH ... femoral neoplasms MeSH C04.588.149.721 --- skull neoplasms MeSH C04.588.149.721.450 --- jaw neoplasms MeSH C04.588.149.721. ...
... the ratio of the bronchial wall thickness and the bronchial diameter is between 0.17 and 0.23.[26] ... superior information as compared to CT scans when seeking information about headache to confirm a diagnosis of neoplasm, ... "Bronchial wall thickening". Radiopaedia. Archived from the original on 2018-01-06. Retrieved 2018-01-05.. ... Bronchial wall thickening can be seen on lung CTs, and generally (but not always) implies inflammation of the bronchi.[25] ...
Other neoplasms (or sources of inflammation) should therefore be considered in known or suspected LAM cases in which FDG-PET ... to destroy bronchial cartilage and arteriolar walls, and to occlude the lumen of pulmonary arterioles. There are two major cell ...
December 2004). "Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins". Cancer Research. 64 ... Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ...
... neoplasm seeding MeSH C23.550.727.650.895 --- neoplasms, unknown primary MeSH C23.550.727.655 --- neoplasm recurrence, local ... bronchial fistula MeSH C23.300.575.825 --- urinary fistula MeSH C23.300.575.825.250 --- bladder fistula MeSH C23.300.575.825. ... neoplasm metastasis MeSH C23.550.727.650.560 --- lymphatic metastasis MeSH C23.550.727.650.645 --- neoplasm circulating cells ... MeSH C23.550.727.670 --- neoplasm regression, spontaneous MeSH C23.550.727.700 --- neoplasm, residual MeSH C23.550.737.500 --- ...
Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... Rare subtypes include carcinoid tumors, bronchial gland carcinomas and sarcomatoid carcinomas. The lung is a common place for ... Tan D, Zander DS (2008). "Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review and Update". Int J ... Experience with radical irradiation of bronchial cancer]. Ceskoslovenská Onkológia (in German). 3 (2): 109-115. PMID 13383622. ...
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... "Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer". J. Natl. Cancer Inst. 91 (21): 1863-8 ... The Hallmarks of Cancer as evolutionary adaptations in a neoplasm[edit]. In their landmark paper, The Hallmarks of Cancer,[3] ... Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. Thus, a cell that acquires a mutation ...
cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm. *Mucinous cystic neoplasm ...
Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed ... "Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells". Am. J. Respir. Cell Mol. ... in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, ...
Myelodysplasia,[5] Myeloproliferative neoplasm.[5][15] Dermatologic diseases. Psoriasis,[5] atopic dermatitis,[5] lichen ruber ... Inflammation occurs in the laryngeal, tracheal and bronchial cartilages.[4] Both of these sites are involved in 10% of persons ... Granulomatosis with polyangiitis, bronchial asthma. Nose cartilage involvement/saddle nose. Granulomatosis with polyangiitis, ... Obstructive respiratory failure may develop as the result of either permanent tracheal or bronchial narrowing or chondromalacia ...
Tan D, Zander DS (2008). „Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review and Update". Int J ... Experience with radical irradiation of bronchial cancer]. Ceskoslovenská Onkológia (на језику: German). 3 (2): 109-115. PMID ...
... the ratio of the bronchial wall thickness and the bronchial diameter is between 0.17 and 0.23.[24] ... superior information as compared to CT scans when seeking information about headache to confirm a diagnosis of neoplasm, ... "Bronchial wall thickening". Radiopaedia. Archived from the original on 2018-01-06. Retrieved 2018-01-05.. ... Bronchial wall thickening can be seen on lung CTs, and generally (but not always) impies inflammation of the bronchi.[23] ...
HEPATIC NEOPLASM , Lung Neoplasm , Ipilimumab and Stereotactic Body Radiation Therapy (SBRT) in Advanced Solid Tumors ...
Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Neoplasms. ... Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Non-Small Cell Lung Cancer And Bronchial Disease. The ... how well photodynamic therapy using porfimer sodium works in treating patients with non-small cell lung cancer and bronchial ...
Lung Neoplasms. *Carcinoma, Non-Small-Cell Lung. *Respiratory Tract Neoplasms. *(and 6 more...) ... Autologous Bronchial Basal Cells Transplantation for Treatment of Bronchiectasis. *Bronchiectasis. *Biological: Bronchial basal ... 436 Studies found for: Recruiting, Not yet recruiting, Available Studies , Bronchial Diseases ...
Lung Neoplasms. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract ... Budesonide in Treating Former and Current Smokers With Bronchial Dysplasia. This study has been completed. ... OBJECTIVES: I. Determine the efficacy of inhaled budesonide on the number and grade of bronchial epithelial dysplastic lesions ... A Phase II Trial of Inhaled Budesonide (Pulmicort Turbuhaler) in Persons With Dysplasia of the Bronchial Epithelium. ...
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Bronchial Neoplasms. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory ... Lung Neoplasms Carcinoma, Non-Small-Cell Lung Biological: Tecemotide (L-BLP25) Drug: Single low dose cyclophosphamide Other: ... Past or current history of neoplasm other than lung carcinoma, except for curatively treated non-melanoma skin cancer, in situ ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ...
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Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ... Neoplasms. Erlotinib Hydrochloride. Antineoplastic Agents. Protein Kinase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms ...
Bronchial Neoplasms. Zoledronic acid. Diphosphonates. Bone Density Conservation Agents. Physiological Effects of Drugs. ... Neoplasms by Histologic Type. Neoplasms. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Lung Diseases. ... Lung Neoplasms. Neoplasm Metastasis. Neoplasms, Second Primary. Carcinoma, Non-Small-Cell Lung. Carcinoma, Small Cell. Small ...
Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial Neoplasms. ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. Thoracic Neoplasms. ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ... Neoplasms. Docetaxel. Trastuzumab. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ...
Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Bronchial Neoplasms. Erlotinib ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ... Neoplasms. Paclitaxel. Atezolizumab. Albumin-Bound Paclitaxel. Carboplatin. Antibodies. Immunoglobulins. Antibodies, Monoclonal ...
Bronchial Neoplasms. Lung Neoplasms. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Lung Diseases. ... Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Carcinoma, Bronchogenic. ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ... Neoplasms. Paclitaxel. Albumin-Bound Paclitaxel. Carboplatin. Erlotinib Hydrochloride. Antineoplastic Agents, Phytogenic. ...
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Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ... Neoplasms. Carboplatin. Pemetrexed. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ...
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Bronchial Neoplasms. Lung Neoplasms. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Lung Diseases. ... Prostatic Neoplasms. Carcinoma, Transitional Cell. Head and Neck Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by ... Neoplasms, Squamous Cell. Genital Neoplasms, Male. Urogenital Neoplasms. Genital Diseases, Male. Prostatic Diseases. Antibodies ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Small Cell Lung Carcinoma. Respiratory Tract Neoplasms. ... Neoplasms. Topotecan. Topoisomerase I Inhibitors. Topoisomerase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ...
Thoracic Neoplasms. Neoplasms by Site. Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Respiratory Tract Neoplasms. ...
Respiratory Tract Neoplasms. Thoracic Neoplasms. Lung Diseases. Respiratory Tract Diseases. Carcinoma, Bronchogenic. Bronchial ... Breast Neoplasms. Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases ...

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