Bronchial Hyperreactivity
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Bronchial Provocation Tests
Methacholine Chloride
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Asthma
Methacholine Compounds
Bronchi
Allergens
Histamine
Respiratory Hypersensitivity
Dyspnea, Paroxysmal
A disorder characterized by sudden attacks of respiratory distress in at rest patients with HEART FAILURE and PULMONARY EDEMA. It usually occurs at night after several hours of sleep in a reclining position. Patients awaken with a feeling of suffocation, coughing, a cold sweat, and TACHYCARDIA. When there is significant WHEEZING, it is called cardiac asthma.
Bronchoconstriction
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Eosinophils
Airway Resistance
Lung
Eosinophil Granule Proteins
Skin Tests
Respiratory Function Tests
Hypersensitivity, Immediate
Interleukin-5
Leukotriene C4
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Respiratory Sounds
Bronchoalveolar Lavage Fluid
Aerosols
Guinea Pigs
Immunoglobulin E
Cough
Albuterol
Vital Capacity
Administration, Inhalation
Leukocyte Count
Double-Blind Method
Acetylcholine
Receptor, Muscarinic M2
Interleukin-13
Vagus Nerve
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Hypersensitivity
Cockroaches
Parathion
Trachea
Pulmonary Eosinophilia
Mucus
Th2 Cells
Pyroglyphidae
Ozone
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
Bradycardia
Disease Models, Animal
Toluene 2,4-Diisocyanate
Goblet Cells
Arecoline
An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
Chemokine CCL11
Oxidants, Photochemical
Cissampelos
Inflammation
Airway Remodeling
Eosinophil Major Basic Protein
Vagotomy
Muscle, Smooth
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Vagus Nerve Diseases
Diseases of the tenth cranial nerve, including brain stem lesions involving its nuclei (solitary, ambiguus, and dorsal motor), nerve fascicles, and intracranial and extracranial course. Clinical manifestations may include dysphagia, vocal cord weakness, and alterations of parasympathetic tone in the thorax and abdomen.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Specific Pathogen-Free Organisms
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Interleukin-4
Injections, Intraperitoneal
Neurokinin-1 Receptor Antagonists
Respiratory System
Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. (1/1734)
ICAM-2-deficient mice exhibit prolonged accumulation of eosinophils in lung interstitium concomitant with a delayed increase in eosinophil numbers in the airway lumen during the development of allergic lung inflammation. The ICAM-2-dependent increased and prolonged accumulation of eosinophils in lung interstitium results in prolonged, heightened airway hyperresponsiveness. These findings reveal an essential role for ICAM-2 in the development of the inflammatory and respiratory components of allergic lung disease. This phenotype is caused by the lack of ICAM-2 expression on non-hematopoietic cells. ICAM-2 deficiency on endothelial cells causes reduced eosinophil transmigration in vitro. ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced. (+info)Dose-response slope of forced oscillation and forced expiratory parameters in bronchial challenge testing. (2/1734)
In population studies, the provocative dose (PD) of bronchoconstrictor causing a significant decrement in lung function cannot be calculated for most subjects. Dose-response curves for carbachol were examined to determine whether this relationship can be summarized by means of a continuous index likely to be calculable for all subjects, namely the two-point dose response slope (DRS) of mean resistance (Rm) and resistance at 10 Hz (R10) measured by the forced oscillation technique (FOT). Five doses of carbachol (320 microg each) were inhaled by 71 patients referred for investigation of asthma (n=16), chronic cough (n=15), nasal polyposis (n=8), chronic rhinitis (n=8), dyspnoea (n=8), urticaria (n=5), post-anaphylactic shock (n=4) and miscellaneous conditions (n=7). FOT resistance and forced expiratory volume in one second (FEV1) were measured in close succession. The PD of carbachol leading to a fall in FEV1 > or = 20% (PD20) or a rise in Rm or R10 > or = 47% (PD47,Rm and PD47,R10) were calculated by interpolation. DRS for FEV1 (DRSFEV1), Rm (DRSRm) and R10 (DRSR10) were obtained as the percentage change at last dose divided by the total dose of carbachol. The sensitivity (Se) and specificity (Sp) of DRSRm, DRS10 delta%Rm and delta%R10 in detecting spirometric bronchial hyperresponsiveness (BHR, fall in FEV1 > or = 20%) were assessed by receiver operating characteristic (ROC) curves. There were 23 (32%) "spirometric" reactors. PD20 correlated strongly with DRSFEV1 (r=-0.962; p=0.0001); PD47,Rm correlated significantly with DRSRm (r=-0.648; p=0.0001) and PD47,R10 with DRSR10 (r=-0.552; p=0.0001). DRSFEV1 correlated significantly with both DRSRm (r=0.700; p=0.0001) and DRSR10 (r=0.784; p=0.0001). The Se and Sp of the various FOT indices to correctly detect spirometric BHR were as follows: DRSRm: Se=91.3%, Sp=81.2%; DRSR10: Se=91.3%, Sp=95.8%; delta%Rm: Se=86.9%, Sp=52.1%; and delta%R10: Se=91.3%, Sp=58.3%. Dose-response slopes of indices of forced oscillation technique resistance, especially the dose-response slope of resistance at 10Hz are proposed as simple quantitative indices of bronchial responsiveness which can be calculated for all subjects and that may be useful in occupational epidemiology. (+info)Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (3/1734)
Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper respiratory tract infection, were randomly selected from a large-scale epidemiological survey in Central Norway. All were investigated with flow-volume spirometry, methacholine provocation test, allergy testing and measurement of nasal and exhaled NO concentration in the nonpollen season. Eighteen rhinitic subjects completed an identical follow-up investigation during the following pollen season. Exhaled NO was significantly elevated in allergic rhinitis in the nonpollen season, especially in perennially sensitized subjects, as compared with controls (p=0.01), and increased further in the pollen season (p=0.04), mainly due to a two-fold increase in those with seasonal sensitization. Nasal NO was not significantly different from controls in the nonpollen season and did not increase significantly in the pollen season. Exhaled NO was increased in hyperresponsive subjects, and decreased significantly after methacholine-induced bronchoconstriction, suggesting that NO production occurs in the peripheral airways. In allergic rhinitis, an increase in exhaled nitric oxide on allergen exposure, particularly in hyperresponsive subjects, may be suggestive of airway inflammation and an increased risk for developing asthma. (+info)Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity. (4/1734)
Bronchial asthma is an airway disorder associated with bronchial hyperresponsiveness, variable airflow obstruction and elevated levels of nitric oxide (NO) in exhaled air. The variables all reflect, in part, the underlying airway inflammation in this disease. To understand their interrelationships we have investigated the relationship between exhaled NO levels and clinicophysiological markers of asthma severity. Twenty-six steroid naive atopic asthmatics participated in the analysis. All were given diary cards and were asked to record their peak expiratory flow (PEF) rates twice daily together with their asthma symptom scores and beta-agonist use. Diary cards were collected 2 weeks later and measurements of exhaled NO levels, FEV1 and histamine bronchial hyperreactivity (PC20 histamine) were undertaken. Exhaled NO levels were significantly higher in our study population than in normal control subjects and correlated negatively with PC20 histamine (r = -0.51; P = 0.008) and positively with PEF diurnal variability (r = 0.58; P = 0.002), but not with symptom scores, beta-agonist use of FEV1 (%). We conclude that a significant relationship exists between exhaled NO levels and the two characteristic features and markers of asthma severity, namely bronchial hyperreactivity and PEF diurnal variability. The lack of correlation between symptom score and beta-agonist use, of FEV1 (%) predicted and exhaled NO suggests that these measures are reflective of differing aspects of asthma. (+info)IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. (5/1734)
Viral respiratory infections can cause bronchial hyperresponsiveness and exacerbate asthma. In mice, respiratory syncytial virus (RSV) infection, which induces an immune response dominated by IFN-gamma, results in airway hyperresponsiveness (AHR) and eosinophil influx into the airways, both of which are prevented by pretreatment with anti-IL-5 Ab. To delineate the role of IL-5, IL-4, and IFN-gamma in the development of RSV-induced AHR and lung eosinophilia, we tested the ability of mice deficient in each of these cytokines to develop these symptoms of RSV infection. Mice deficient in either IL-5, IL-4, or IFN-gamma were administered infectious RSV intranasally, and 6 days later, airway responsiveness to inhaled methacholine was assessed by barometric body plethysmography, and numbers of lung eosinophils and production of IFN-gamma, IL-4, and IL-5 by mononuclear cells from peribronchial lymph nodes were monitored. RSV infection resulted in airway eosinophilia and AHR in both IL-4- and IFN-gamma-deficient mice, but not in IL-5-deficient mice. Reconstitution of IL-5-deficient mice with IL-5 restored these responses and enhanced the responses in IL-4-deficient mice. Anti-VLA-4 (very late Ag-4) treatment prevented lung eosinophilia and AHR following RSV infection and IL-5 reconstitution. We conclude that in response to RSV, IL-5 is essential for the influx of eosinophils into the lung and that eosinophils in turn are critical for the development of AHR. IFN-gamma and IL-4 are not essential for these responses to RSV infection. (+info)Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis. (6/1734)
BACKGROUND: Inhaled corticosteroids are the most efficacious anti-inflammatory drugs in asthma. International guidelines also advocate the early introduction of inhaled corticosteroids in corticosteroid naive patients. A study was undertaken to assess the effects of inhaled corticosteroids on bronchial hyperresponsiveness in patients with corticosteroid naive asthma by conventional meta-analysis. METHODS: A Medline search of papers published between January 1966 and June 1998 was performed and 11 papers were selected in which the patients had no history of treatment with inhaled or oral corticosteroids. Bronchial responsiveness to bronchoconstricting agents was considered as the main outcome parameter. Doubling doses (DD) of histamine or methacholine were calculated. RESULTS: The total effect size of inhaled corticosteroids (average daily dose 1000 microg) versus placebo in the 11 studies was +1.16 DD (95% confidence interval (CI) +0.76 to +1.57). When only the eight short term studies (2-8 weeks) were analysed the effect size of the bronchoconstricting agent was +0.91 DD (95% CI +0.65 to +1.16). No relationship was found between the dose of inhaled corticosteroid used and the effect on bronchial responsiveness. CONCLUSION: This meta-analysis in patients with corticosteroid naive asthma indicates that, on average, high doses of inhaled corticosteroids decrease bronchial hyperresponsiveness in 2-8 weeks. It remains unclear whether there is a dose-response relationship between inhaled corticosteroids and effect on bronchial hyperresponsiveness. (+info)Deficiency of nitric oxide in polycation-induced airway hyperreactivity. (7/1734)
Using a perfused guinea-pig tracheal tube preparation, we investigated the role of endogenous nitric oxide (NO) in polycation-induced airway hyperreactivity (AHR) to methacholine. Intraluminal (IL) administration of the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME; 100 microM) caused a 1.8 fold increase in the maximal contractile response (Emax) to IL methacholine compared to control, without an effect on the pEC50 (-log10 EC50). The polycation poly-L-arginine (100 microg ml(-1), IL) similarly enhanced the Emax for methacholine; however, the pEC50 value was also increased, by one log10 unit. L-NAME had no effect on the enhanced methacholine response of poly-L-arginine-treated airways, while the enhanced agonist response was completely normalized by the polyanion heparin (25 u ml(-1), IL). In addition, the effect of L-NAME was fully restored in the poly-L-arginine plus heparin treated airways. The results indicate that, in addition to enhanced epithelial permeability, a deficiency of endogenous NO contributes to polycation-induced AHR. The latter finding may represent a novel mechanism of AHR induced by eosinophil-derived cationic proteins in allergic asthma. (+info)Update on the "Dutch hypothesis" for chronic respiratory disease. (8/1734)
BACKGROUND: Many patients with chronic obstructive lung disease show increased airways responsiveness to histamine. We investigated the hypothesis that increased airways responsiveness predicts the development and remission of chronic respiratory symptoms. METHODS: We used data from 24-year follow-up (1965-90) of 2684 participants in a cohort study in Vlagtwedde and Vlaardingen, Netherlands. Increased airways responsiveness was defined as a PC10 value (concentration of histamine for which challenge led to a 10% fall in forced expiratory volume in 1 s) of less than 8 mg/ml. Information on respiratory symptoms was collected by means of a standard questionnaire every 3 years. Logistic regression was used to control for age, area of residence, cigarette smoking status, and sex. FINDINGS: Participants with increased airways responsiveness (1281 observations) were more likely than those without increased airways responsiveness (5801 observations) to develop the following symptoms during any 3-year follow-up interval: chronic cough (odds ratio 1.9 [95% CI 1.2-2.9]), chronic phlegm (2.0 [1.3-3.0]), dyspnoea (2.3[1.5-3.5]), asthmatic attacks (3.7[2.2-6.1]), and persistent wheeze (2.7[1.7-4.4]). The estimate of the odds ratio for the development of any of the six symptoms was 1.7 (1.2-2.3). Participants with increased airways responsiveness were less likely than those without this characteristic to show remission of these respiratory symptoms. The estimate of the odds ratio for the remission of any of the six symptoms was 0.42 (0.28-0.61). INTERPRETATION: These prospective analyses show that increased airways responsiveness is positively associated with the development of chronic respiratory symptoms and negatively associated with the remission of these symptoms in adults. (+info)
Bronchial hyperresponsiveness - Wikipedia
Bronchial Hyperresponsiveness | Technology Trends
A comparison between different methods for detecting bronchial hyperreactivity. Bronchial hyperreactivity: methods of study.<...
Perception of bronchoconstriction and bronchial hyper-responsiveness in asthma | Clinical Science | Portland Press
Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.<...
Requirement for neuropeptide Y in the development of type 2 responses and allergen-induced airway hyperresponsiveness and...
Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with...
Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics - Full Text View - ClinicalTrials.gov
Measuring the prevalence of bronchial hyper-responsiveness in children. | Base documentaire | BDSP
Predictive value of childhood airway hyperresponsiveness to indirect stimuli: 10-year longitudinal study<...
The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma - UEA Digital Repository
Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness<...
Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization. | JEM
Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice
Lin, J.T., Hiroshi, I., Suzuki, T., et al. (1994) Eosinophilic Airway Inflammation and Airway Hyperresponsiveness. Chinese...
Corticosteroids enhance CD8<sup>+</sup> T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating...
PRIME PubMed | Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive...
Critical role for IL-13 in the development of allergen-induced...
Effect of oral administration with pravastatin and atorvastatin on airway hyperresponsiveness and allergic reactions in...
Airway hyperresponsiveness: From molecules to bedside<...
Role of atopy in the natural history of wheeze and bronchial hyper-responsiveness in childhood. - PubMed - NCBI
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with...
The Effect of Phytocannabinoids on Airway Hyper-Responsiveness, Airway Inflammation, and Cough | Journal of Pharmacology and...
Eosinophils in Asthma and Airway Hyperresponsiveness [3] (multiple letters) - Nuffield Department of Medicine
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Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in...
Ozone-induced airway hyperresponsiveness in patients with asthma: role of neutrophil-derived serine proteinases. - PubMed -...
Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine...
HKU Scholars Hub: Analysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis
Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91. | Thorax
Relationship between Bronchial Hyperresponsiveness and Impaired Lung Function after Infantile Asthma
Diesel exhaust enhances airway responsiveness in asthmatic subjects | European Respiratory Society
Endothelin receptor alterations in equine airway hyperreactivity<...
JCI -
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
METHODS TO TREAT ALLERGIC CONDITIONS - Patent application
Are asymptomatic airway hyperresponsiveness and allergy risk factors for asthma? A longitudinal study | European Respiratory...
Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an...
NIOSHTIC-2 Publications Search - 20022832 - Interleukin-1 -induced airway hyperresponsiveness enhances substance P in...
Bronchial hyperresponsiveness in an adult population in Helsinki - decreased FEV(1 ) the main determinant.
Targeting actin dynamics to inhibit airway hypperresponsiveness and inflammation - Indiana University School of Medicine
Effect of parental smoking on wheezy bronchitis and bronchial hyperreactivity
Collaborative Studies on the Genetics of Asthma (CSGA) - Full Text View - ClinicalTrials.gov
Allergic throat hyperresponsiveness (AHR) in OVA-sensitized and challenged mice, mediated by - Small molecule epigenetic...
name:P G Hellewell found 1 record • Arctic Health
Ventilation Heterogeneity and Airway Hyperreactivity in Children with Well Controlled Asthma | OMICS International
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What is Refractory Asthma?
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COPD in Asia Explained by Canadian Health&Care Mall: Associated Risk Factors
What is Airway Inflammation? (with pictures)
Proxicromil
Furukawa, Clifton T. (1984). "Other pharmacologic agents that may affect bronchial hyperreactivity". Journal of Allergy and ...
MED27
Relation between manifest bronchial obstruction and bronchial hyperreactivity (author's transl)]". Zeitschrift für Erkrankungen ...
Asthma-related microbes
van Herwerden, L (1995). "Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy ... 1976). "Changes in bronchial reactivity after administration of live attenuated influenza virus". Am. Rev. Respir. Dis.: 194- ... This shows that in addition to causing airway hyperreactivity, rhinovirus also promotes the onset of non-atopic asthma. ... pneumoniae infection has been indicated as a possible mechanism leading to bronchial asthma. This is because the increase of ...
Occupational asthma
A non-specific bronchial hyperreactivity test can be used to support the diagnose occupational asthma. It involves measuring ...
Fremitus
The obstruction can be due to mucus or other secretions in the airway,: 411 bronchial hyperreactivity, or tumors. See rhonchus ... also known as bronchial fremitus, is a palpable vibration produced during breathing caused by partial airway obstruction. ... as these areas are closest to the bronchial trifurcation (right side) or bifurcation (left side). Tactile fremitus is ...
Perfume intolerance
"Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity ...
Acute severe asthma
In addition, ongoing airway inflammation is thought to cause airway hyperreactivity characteristic of asthma. The more severe ... Together, these mediators cause bronchial smooth muscle constriction, vascular leakage, inflammatory cell recruitment (with ...
Methacholine
... is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in ... This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized ...
Prostaglandin DP1 receptor
T variant with increased incidences of asthma and/or bronchial hyper-reactivity. The intrinsic variants rs17831675, rs17831682 ... 2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 23-7. ...
Chlamydia pneumoniae
... bronchial hyper reactivity and peak flow but not FEV1. More recent positive results of long-term treatment with azithromycin on ... Webley WC, Salva PS, Andrzejewski C, Cirino F, West CA, Tilahun Y, Stuart ES (May 2005). "The bronchial lavage of pediatric ... Hahn DL, Grasmick M, Hetzel S, Yale S (2012). "Azithromycin for bronchial asthma in adults: an effectiveness trial". Journal of ... Schmidt SM, Müller CE, Bruns R, Wiersbitzky SK (October 2001). "Bronchial Chlamydia pneumoniae infection, markers of allergic ...
Bronchial hyperresponsiveness
... (or other combinations with airway or hyperreactivity, BH used as a general abbreviation) is a ... Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine ... Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people with chronic obstructive pulmonary ... Bronchial hyperresponsiveness has been associated with gas cooking among subjects with the GSTM1 null genotype. Logan, Carolynn ...
Bronchial challenge test
People with pre-existing airway hyperreactivity, such as asthmatics, will react to lower doses of drug. Sometimes, to assess ... A bronchial challenge test is a medical test used to assist in the diagnosis of asthma. The patient breathes in nebulized ... The bronchial challenge test is physically demanding, and the results can be affected by muscular weakness or exhaustion. The ... Dixon C (February 1983). "The bronchial challenge test: a new direction in asthmatic management". J Natl Med Assoc. 75 (2): 199 ...
Reactive airway disease
... swollen mucous membrane in the bronchial tube, and/or hypersensitive bronchial tubes. In order to make a formal asthma ... Patients that have been diagnosed with RADS will likely have methacholine airway hyperreactivity, yet other tests that also ... swollen mucous membrane in the bronchial tube, and/or hypersensitive bronchial tubes. Physicians most commonly label patients ... Symptoms may also include, but are not limited to, coughing, shortness of breath, excess mucus in the bronchial tube, ...
Interleukin 17
IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial ... an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway ...
Salbutamol
... which are the predominant receptors on the bronchial smooth muscles. Activation of these receptors causes adenylyl cyclase to ... which can cause airway hyperreactivity and inflammation. Potential formulation of the R form as an enantiopure drug is ... leading to hyperpolarization and relaxation of bronchial smooth muscles. Salbutamol is either filtered out by the kidneys ...
Acute inhalation injury
In vitro, exposure of human bronchial epithelial cells or human pulmonary alveolar epithelial cells to agents such as hydrogen ... and airway hyperreactivity in firefighters at the world trade center site. Disaster Med Public Health Prep. 2:33-9. Berninger A ... Gas exchange is affected by increases in the dispersion of both alveolar ventilation and cardiac output because bronchial and ... 2010) Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine ...
Pendrin
Another little-understood role of pendrin is in airway hyperreactivity and inflammation, as during asthma attacks and allergic ... "Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels". ... hyperreactivity, and increased mucus production. These symptoms could result from pendrin's effects on ion concentration in the ... "Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary ...
Innate lymphoid cell
The dysregulation of ILCs can lead to immune pathology such as allergy, bronchial asthma and autoimmune disease. The ... "Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity ...
HuGE Navigator|HuGE Literature Finder|PHGKB
Query Trace: Bronchial Hyperreactivity and CD14[original query] CD14 gene polymorphism is not associated with asthma but rather ... with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma. Respiratory medicine 2011 Oct 105 ...
Chlorine Gas Release Associated with Employee Language Barrier - Arkansas, 2011
... bronchial hyperreactivity is occurring (positive test result); if PC20 is 4-16 mg/mL, borderline bronchial hyperreactivity is ...
NIOSHTIC-2 Search Results - Full View
For individuals with COPD and bronchial hyperreactivity the 95th percentiles for year-to-year changes were about 15% and higher ...
Hypomagnesemia: Practice Essentials, Pathophysiology, Etiology
72] but it has been shown to reduce bronchial hyperreactivity to methacholine and other measures of allergy. [73] ...
Aeroallergens: Practice Essentials, Overview, Avoidance Measures and Interventions
Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet. 1982 Sep 25. 2(8300):675-8. [QxMD MEDLINE ... Storm van Leeuwen W. Allergic diseases: diagnosis and treatment of bronchial asthma, hay fever and other allergic diseases. ... Dust sensitization in bronchial asthma. Med Clin North Am. 1921. 5:751. ...
Allergic and Environmental Asthma: Overview, Patient History, Differential Diagnosis
... increased bronchial reactivity, and airway inflammation. Asthma results from complex interactions among inflammatory cells, ... During pregnancy, airway hyperreactivity (AHR) generally is stable to improved 69% of the time and worse 31% of the time. ... Clinically, the manifestations of the EAR in the airway include bronchial constriction, airway edema, and mucus plugging. These ... Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and ...
Allergic and Environmental Asthma: Overview, Patient History, Differential Diagnosis
... increased bronchial reactivity, and airway inflammation. Asthma results from complex interactions among inflammatory cells, ... During pregnancy, airway hyperreactivity (AHR) generally is stable to improved 69% of the time and worse 31% of the time. ... Clinically, the manifestations of the EAR in the airway include bronchial constriction, airway edema, and mucus plugging. These ... Asthma is a clinical syndrome characterized by episodic reversible airway obstruction, increased bronchial reactivity, and ...
Pulmonary Function Testing: Spirometry, Lung Volume Determination, Diffusing Capacity of Lung for Carbon Monoxide
Nonspecific bronchial hyperreactivity also can be found in chronic obstructive pulmonary disease, cystic fibrosis, and ... Nonspecific bronchial hyperreactivity is characteristic of asthma but occurs after a viral respiratory illness, with resolution ... Failure to demonstrate bronchial hyperreactivity does not totally exclude asthma, particularly asthma triggered by specific ... Bronchial spasm, airway inflammation, excessive secretions in the airway, and loss of lung elastic recoil increase airways ...
Pulmonary Function Testing: Spirometry, Lung Volume Determination, Diffusing Capacity of Lung for Carbon Monoxide
Nonspecific bronchial hyperreactivity also can be found in chronic obstructive pulmonary disease, cystic fibrosis, and ... Nonspecific bronchial hyperreactivity is characteristic of asthma but occurs after a viral respiratory illness, with resolution ... Failure to demonstrate bronchial hyperreactivity does not totally exclude asthma, particularly asthma triggered by specific ... Bronchial spasm, airway inflammation, excessive secretions in the airway, and loss of lung elastic recoil increase airways ...
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Query Trace: Bronchial Hyperreactivity and GSTP1[original query] MOLECULAR GENETIC ASPECTS OF BRONCHIAL HYPERREACTIVITY IN ...
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Bronchial Hyperreactivity 1 0 Diabetes Mellitus, Type 1 1 0 Pulmonary Disease, Chronic Obstructive 1 0 ...
IMSEAR at SEARO: Bronchial hyperreactivity in chronic obstructive airways disease.
Association between − 308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma - Nuffield...
Chemical Worker's Lung: Practice Essentials, Pathophysiology, Etiology
Bronchial Reactivity and the Course of Lung Function - WTC Health Program Research Gateway
They show that bronchial hyperreactivity is one factor that can be considered predictive of poor recovery from particulate ... This study assesses the post-9/11 courses of lung function as influenced by bronchial hyperreactivity (BHR) a biomarker for ... Bronchial hyperreactivity-abnormal sensitivity to inhaled bronchoconstrictive agents, is a biomarker for susceptibility to ... In about 30%, there is accompanying bronchial hyperreactivity (easily triggered airway narrowing). This study will re-examine a ...
NIOSHTIC-2 Search Results - Full View
Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample
Bronchial Hyperreactivity / etiology * Bronchial Hyperreactivity / prevention & control* * Bronchial Provocation Tests * Diet * ... Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample Lancet. 1994 Aug 6; ... We measured airway reactivity to methacholine in 2415 individuals, defining hyper-reactivity as a 20% fall in FEV1 after a ... and a reduced risk of airway hyper-reactivity and wheezing in a random sample of adults. In 2633 adults aged 18-70 sampled from ...
Respiratory problems in children with neurological impairment | Archives of Disease in Childhood
Proxicromil - Wikipedia
Multifaceted Approach to Assess Indoor Environmental Quality | Blogs | CDC
Most downloaded papers - Scientific Research Publishing
Mechanical determinants of airways hyperresponsiveness
NIOSHTIC-2 Search Results - Full View
The high alkalinity of WTC dust produced bronchial hyperreactivity, persistent cough, and increased risk of asthma. Plausible ... Evaluation of 10,116 firefighters showed exposure-related increases in cough and bronchial hyperreactivity. Evaluation of 183 ... Mice exposed to WTC dust showed only moderate pulmonary inflammation but marked bronchial hyperreactivity. ...
Tradjenta (linagliptin) dosing, indications, interactions, adverse effects, and more
EP1452524A1 - '2-oxo-1-pyrrolidine derivative and its pharmaceutical uses' - Google Patents
Two Phase 3 Studies of the Tezacaftor/Ivacaftor Combination Treatment Met Primary Endpoints with Statistically Significant...
Albuterol and Discomfort, a phase IV clinical study of FDA data - eHealthMe
Bronchial hyperreactivity: 108 reports. *Bronchial wall thickening: 108 reports. *Bronchiectasis (abnormal widening of the ... Increased bronchial secretion: 118 reports. *Increased tendency to bruise (increased tendency to injure the underlying soft ... Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 858 reports ... Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 416 ...
Asthma in Children - Diagnosis and Management - Province of British Columbia
2. Tests of bronchial hyperreactivity. *If spirometry is normal and asthma is still suspected, methacholine challenge or an ... Asthma is a chronic inflammatory disease of the airways that is characterized by bronchial hyperreactivity and variable airway ... documented evidence of reversible obstruction or bronchial hyperreactivity with lung function testing (see Investigations or ...
These healthy foods can help protect against the effects of smoky air this fire season
KoreaMed
Reactive dye induced occupational asthma without nonspecific bronchial hyperreactivity Park HS, Lee MK, Hong CS ... We report two asthmatic patients with normal bronchial hyperresponsiveness and one asthmatic patient with mild bronchial ... Current asthma is often excluded by the presence of normal bronchial hyperresponsiveness. ...
Lung Health Study II - Full Text View - ClinicalTrials.gov
... bronchial hyperreactivity, atopic status, and smoking status. Recruitment was initiated in November 1994 and ended November 28 ... variously influence short-term bronchial hyperreactivity, improve lung function acutely or short-term, and slow rate of decline ... Bronchial activity was tested at baseline, at nine months, and at three-and-a-half years using a methacholine inhalation ... There are various published studies suggesting that inhaled steroids reduce bronchial lavage markers of inflammation, ...
76809 PDFs | Review articles in PULMONARY MEDICINE
Internal Medicine - Grants - Mayo Clinic
ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests |...
Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine ... General considerations for bronchial challenge testing. Indications. Bronchial challenge, or bronchoprovocation, testing is ... High prevalence of bronchial hyperresponsiveness and asthma in ice hockey players. Eur Respir J 1998; 12: 13-16. ... Indications for bronchial challenge testing. BCTs are done to assess the presence and degree of airway responsiveness to a ...
HuGE Navigator|Genopedia|PHGKB
Table - Upsurge of Enterovirus D68, the Netherlands, 2016 - Volume 23, Number 1-January 2017 - Emerging Infectious Diseases...
Bronchial hyperreactivity, failure to thrive. Bronchial obstruction, respiratory failure. Yes/8. 13. Jul 22. 5 y/F. Asthma. ... Bronchial hyperreactivity. Asthma exacerbation. No. 19. Jul 25. 5 mo/M. 22q11 deletion, tetralogy of Fallot, tracheal stoma. ... Bronchial hyperreactivity. Status asthmaticus. Yes/2. 24. Jul 30. 51 y/F. Autologous stem cell transplantation. Influenza-like ...
HyperresponsivenessInflammationReactivityRespiratoryObstructionDegree of bronchialLungHypersensitivityTreatment for bronchial asthmaEpithelialGreater bronchialBronchoconstrictionMucosaEtiologyHyper-responsivenessSymptomsBronchospasmLungsAtopicPatientsReversibleTubesCoughEosinophilsPersistentAllergicChronicEmphysemaReductionInflammatoryMethacholineStimuliAirways diseaseSpasmSeverityPollutionAcuteInvolves
Hyperresponsiveness9
- Current asthma is often excluded by the presence of normal bronchial hyperresponsiveness. (koreamed.org)
- We report two asthmatic patients with normal bronchial hyperresponsiveness and one asthmatic patient with mild bronchial hyperresponsiveness (methacholine. (koreamed.org)
- The pathophysiology of asthma is complex and involves airway inflammation, intermittent airflow obstruction, and bronchial hyperresponsiveness. (medscape.com)
- Airway hyperresponsiveness or bronchial hyperreactivity in asthma is an exaggerated response to numerous exogenous and endogenous stimuli. (medscape.com)
- CONCLUSION: Bronchial hyperresponsiveness tests can be used to support the evaluation of an air quality intervention. (bmj.com)
- The demonstrated reduction in bronchial hyperresponsiveness is an indication of the effectiveness of the intervention. (bmj.com)
- In addition, it produces mucosal edema, secretion and a delayed and longlasting bronchial hyperresponsiveness. (pharmacy180.com)
- The AR is a risk factor for the development of obstruction in lower airways and clinical studies with asthmatic patients demonstrated reduction of bronchial hyperresponsiveness and asthma symptoms after just nasal topical treatment. (unicamp.br)
- Bronchial asthma is a chronic inflammatory disorder of the airways associated with airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing particularly at night or in the early morning. (onlineanesthesiatools.com)
Inflammation12
- Mice exposed to WTC dust showed only moderate pulmonary inflammation but marked bronchial hyperreactivity. (cdc.gov)
- There are various published studies suggesting that inhaled steroids reduce bronchial lavage markers of inflammation, variously influence short-term bronchial hyperreactivity, improve lung function acutely or short-term, and slow rate of decline in lung function. (clinicaltrials.gov)
- Antibodies directed against key epitopes of the crystallization interface dissolved pre-existing CLC in patient-derived mucus within hours, and reversed crystal driven inflammation, goblet cell metaplasia, IgE synthesis and bronchial hyperreactivity in a humanized asthma model. (cam.ac.uk)
- Eosinophils are particularly evident in chronic lung inflammation where their products appear to play roles both in bronchial hyper-responsiveness and in tissue remodeling, leading to compromised lung function [ 5 , 6 ]. (ispub.com)
- The mechanism of inflammation in asthma may be acute, subacute, or chronic, and the presence of airway edema and mucus secretion also contributes to airflow obstruction and bronchial reactivity. (medscape.com)
- Paper I: Scandinavian Journal of Immunology 65 (2), pages 118-125,(2007) L.-Z. Sun, S. Elsayed, A. M. Bronstad, T. Van Do, A . Irgens, N. P. Aardal & T. B. Aasen, Airway Inflammation and Bronchial Remodelling in Toluene Diisocyanate-exposed BALB/c Mouse Model. (uib.no)
- Paper III: Li-Zhi Suna, Thien Van Dob, Erik Florvaag, Nils P Aardald, Jørn Skavlanda and Kirsi Vaali, Toluene diisocyanate-induced bronchial hyper-reactivity and neutrophilic inflammation deviates from the eosinophil-dominant response to ovalbumin. (uib.no)
- Inflammation in the ASM bundles and submucosa of bronchial biopsies is positively associated with impaired airway mechanics during DI in asthma [ 7 ]. (sch.ac.kr)
- Starting in the 1980s with ever-increasing information and knowledge about asthma, bronchial tube inflammation was considered by most authorities as the basic underlying problem. (aarogya.com)
- In summary, we now recognize asthma as a condition which begins with inflammation of the bronchial membranes which results in changes that bring about bronchial hyper-reactivity, which in turn cause the physical symptoms of wheezing, coughing, shortness of breath and chest tightness, i.e. the classic symptoms of asthma. (aarogya.com)
- These steroids have anti-inflammatory properties that lower inflammation and hyperreactivity of airways caused due to asthma. (canadapharmacy.com)
- Corticosteroids are considered the most effective medication currently available for the treatment of inflammation in the bronchial tubes. (nmihi.com)
Reactivity10
- This study will re-examine a large number of firefighters who had bronchial reactivity soon after 9/11 to determine whether those with bronchial hyper-reactivity at onset have persistent hyperactivity more than ten years later, whether they have accelerated lung function decline, and whether those treated with anti-asthma medications were more likely to show resolution of bronchial hyperactivity and/or show less rapid decline in lung function. (cdc.gov)
- Did bronchial reactivity influence the course of recovery or worsening function after WTC exposure? (cdc.gov)
- Bronchial reactivity remained relatively stable, with a trend toward increasing reactivity.76% of firefighters reported using either inhaled and/or oral corticosteroids between 2001-2013. (cdc.gov)
- 10 years after 9/11, to define the natural history of WTC-associated OAD, to determine whether clinical outcomes varied according to their degree of bronchial reactivity, and to assess the influence of anti-inflammatory treatment (oral and/or inhaled corticosteroids). (cdc.gov)
- We found that steroid therapy was significantly associated with recovery of lung function and that bronchial reactivity, which tended to persist or slightly worsen over the decade since 9/11, was significantly associated with worsening lung function. (cdc.gov)
- Both effects were fairly strong, with the highest steroid dose predicting about 5 percentage points better result than those who did not receive steroids, and the most bronchial reactivity predicting about 5 percentage points worse result. (cdc.gov)
- Consumption of quercetin-rich foods may help reduce the risk of asthma, bronchial hyper-reactivity and COPD. (dailybulletin.com)
- Bronchial hyperreactivity (BHR)(a 20% decrease in FEV1 provoked by a cumulative dose of histamine less than 7.8 mumol) and bronchial reactivity slope (BR slope) (percentage change in logarithmic scale in FEV1 per unit dose of histamine) were used to estimate responses to a histamine challenge. (bmj.com)
- Alerzine substantially reduces the asthmatic patient's bronchial hyper reactivity to histamine. (plaintips.com)
- The term bronchial hyper-reactivity ( or hyper-responsiveness ) refers to unnatural sensitiveness to a broad scope of stimulations such as irritant chemicals, cold air, stimulation drugs, etc. , all of which can ensue in bronchoconstriction. (lyceecharlesdegaulle.eu)
Respiratory9
- The respiratory illness known as bronchial asthma (BA) is characterized by a persistent inflammatory process, reversible airway constriction, and airway hyperreactivity. (tutorialspoint.com)
- Bronchial asthma is a chronic, inflammatory disease of the respiratory tract , which is characterized by bronchial hyperreactivity and respiratory obstruction which is reversible (spontaneously or under influence of bronchodilater) marked by wheezing ,shortness of breath,chest tightness and coughing. (bhaskarhealth.com)
- Worsening symptoms of the both types include bronchial irritation by the streneous exercise ,exposure to cold air,dust,tobbaco smoke,fumes, emotional stress and respiratory infections. (bhaskarhealth.com)
- Salmeterol (Serevent®) is a long acting ß2-agonist which has been shown to improve respiratory function in two-thirds of adult patients with bronchial lability (Bargon et al, 1996). (cysticfibrosis.online)
- T-cell tolerance, induced by respiratory exposure to allergen, can inhibit the development of airway hyperreactivity (AHR), a cardinal feature of asthma, and we show here that regulatory T (T(R)) cells can mediate this protective effect. (stanfordhealthcare.org)
- Mature pulmonary dendritic cells in the bronchial lymph nodes of mice exposed to respiratory allergen induced the development of T(R) cells, in a process that required T-cell costimulation via the inducible costimulator (ICOS-ICOS-ligand pathway. (stanfordhealthcare.org)
- In most cases, atopic dermatitis is combined with respiratory allergies: bronchial asthma and allergic rhinitis. (medica-tour.com)
- Damage of the respiratory system is caused by the action of a pathological agent on the walls of the bronchi and their hyperreactivity, which are provoked by a combination of internal characteristics of the body and the influence of external factors. (inhalers-online.com)
- reactive airway disease (rad) is a term used to refer to respiratory conditions in which the bronchial tubes in the lungs overreact to an irritant, the narrow airway is caused by muscle spasms around the airway. (ancientvalue.com)
Obstruction2
- Asthma is a chronic inflammatory disease of the airways that is characterized by bronchial hyperreactivity and variable airway obstruction which results in recurrent episodes of wheezing, breathlessness, chest tightness and/or coughing that can vary over time and in intensity. (gov.bc.ca)
- Asthma is a disease that involves periodic episodes of severe but reversible bronchial obstruction in person with hypersensitive or hyperresponsive airway. (nursinganswers.net)
Degree of bronchial1
- Approximately 50% of patients have some degree of bronchial lability (asthma) which will improve with a bronchodilator (Eggleston et al, 1988). (cysticfibrosis.online)
Lung6
- This study assesses the post-9/11 courses of lung function as influenced by bronchial hyperreactivity (BHR) a biomarker for susceptibility to asthma, and by corticosteroid treatment. (cdc.gov)
- Bronchial hyperreactivity-abnormal sensitivity to inhaled bronchoconstrictive agents, is a biomarker for susceptibility to asthma, and may predict rapid decline in lung function. (cdc.gov)
- It can be dangerous to smoke marijuana to help bronchial asthma as a result of it may possibly additional irritate lungs and lead to infections and the risk of lung most cancers cbd for asthma. (culhost.com)
- A 2019 examine revealed within the European Journal of Pharmacology discovered that CBD use may scale back inflammatory reactions and promote the restoration of lung perform in sufferers with allergy-induced bronchial asthma (1). (culhost.com)
- Inhaled glucocorticosteroids are the basis of anti-inflammatory therapy for asthma, they prevent symptoms and exacerbations of the disease, improve lung function, and reduce bronchial hyperreactivity. (vcu-ntc.org)
- In already sensitized animals, blocking OX40-OX40L interactions at the time of inhalation of aerosolized antigen suppressed memory effector accumulation in lung draining lymph nodes and lung, and prevented eosinophilia, airway hyperreactivity, mucus secretion, and Th2 cyto-kine production. (silverchair.com)
Hypersensitivity4
- One Australian study that observed the dietary habits of 1600 adults, found that those who consumed apples and pears had lower risk of asthma and bronchial hypersensitivity. (cleansejoy.com)
- Hypersensitivity to linagliptin or any of the excipients in TRADJENTA, reactions such as anaphylaxis, angioedema, exfoliative skin conditions, urticaria, or bronchial hyperreactivity have occurred. (tradjenta.com)
- Other adverse reactions reported in clinical studies with treatment of linagliptin monotherapy were hypersensitivity (e.g., urticaria, angioedema, localized skin exfoliation, or bronchial hyperreactivity) and myalgia. (mdtodate.com)
- Other factors, such as pungent odors, colds, exercise, cold air, emotions, can cause a reaction similar to an allergic one, but the cause of which is hypersensitivity (hyperreactivity) of the airways caused before this contact with the allergen. (medica-tour.com)
Treatment for bronchial asthma3
- There's an rising physique cannabis and asthma of analysis concentrating on CBD's potential instead treatment for bronchial asthma signs. (culhost.com)
- Homeopathy has more than 100 preventive and curative medicines in Treatment For Bronchial Asthma that works very well for patients of all ages. (welcomecure.com)
- Homeopathic Treatment For Bronchial Asthma is very subtle and gentle and brings immense relief to the patient without causing any side-effects. (welcomecure.com)
Epithelial1
- There is normally a blood eosinophilia and besides some grade of loss of bronchial epithelial tissue. (lyceecharlesdegaulle.eu)
Greater bronchial2
- There also is some evidence of greater bronchial hyperreactivity in women, although conflicting findings have been reported. (patientcareonline.com)
- Inhaled long-acting beta 2 -agonists are preferred over oral sustained-release formulations due to their longer duration of action, greater bronchial protection during exercise, and a lower incidence of adverse events. (medicalbrandnames.com)
Bronchoconstriction1
- Because of the potential for severe bronchoconstriction, the bronchial challenge testing with ARIDOL should not be performed in any patient with clinically apparent asthma or very low baseline pulmonary function tests (e.g. (methapharmrespiratory.com)
Mucosa2
- reported that increased levels of Th2 cytokines were detected in the airways and bronchial mucosa of TDI asthmatics. (uib.no)
- Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. (nature.com)
Etiology1
- Thus, the use of a Ventolin inhaler as a rescue bronchodilator can serve as an example of rational and compliant pharmacotherapy of bronchial asthma, regardless of its etiology and severity. (vcu-ntc.org)
Hyper-responsiveness1
- This damage results in the development of easily irritated bronchial tubes, which is called hyper-responsiveness. (aarogya.com)
Symptoms5
- In removing the scum of Kapha from the bronchial tubes, Kantkari may be very effective in oxygenating the blood and relieving signs and symptoms of IPF, and providing a person with solace in pain. (cowurine.com)
- As mentioned, some folks discover it very difficult to manage the symptoms of bronchial asthma. (culhost.com)
- Up until 15 years ago, asthma was considered by physicians to be simply a spastic disease of the bronchial tubes which in turn led to all the other symptoms associated with it. (aarogya.com)
- The also-twitchy bronchial tubes will react by going into a spasm, which leads to the symptoms of shortness of breath, coughing, wheezing and chest tightness. (aarogya.com)
- A decrease in the peak flow can show that the bronchial tubes have narrowed even before asthma symptoms develop. (peacehealth.org)
Bronchospasm4
- Allergy & Asthma Community and Joanna Zeiger, PhD, hosted a Twitter chat on June eleven on cannabis (marijuana) use and its affect on individuals with bronchial asthma, exercise-induced bronchospasm, allergic reactions, eczema and urticaria. (culhost.com)
- Bronchial challenge testing with ARIDOL should only be conducted by trained professionals under the supervision of a physician familiar with all aspects of the bronchial challenge test and the management of acute bronchospasm. (methapharmrespiratory.com)
- Inhalation of albuterol with a nebulizer is prescribed for acute bronchospasm which is not controlled by conventional therapy with metered-dose aerosols or powder inhalers, as well as for severe exacerbation of bronchial asthma. (vcu-ntc.org)
- Because of airway hyperreactivity, bronchospasm may readily be precipitated by instrumentation, a variety of drugs, and perioperative complications such as aspiration, infection, or trauma. (onlineanesthesiatools.com)
Lungs5
- It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree. (researchgate.net)
- During an bronchial asthma attack, the air passages leading to the lungs develop into slender and often stuffed with mucus and other irritants. (culhost.com)
- Asthma is a chronic inflammatory disease that Causes hyperreactivity of the airways of lungs leading to wheezing, shortness of breath, chest tightness, and coughing. (welcomecure.com)
- rad occurs when your bronchial tubes, which bring air into your lungs, overreact to an irritant, swell, and anytime you have difficulty breathing from your bronchial tubes, swelling, and overreaction to an irritant, it can be referred to as reactive airway disease. (ancientvalue.com)
- Your peak flow drops when the tubes that carry air to the lungs (bronchial tubes) narrow. (peacehealth.org)
Atopic1
- Humbert, M., Durham, S.R. & Ying, S. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non-atopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. (nature.com)
Patients8
- In this episode, Dr Rizzo interviews Geoffrey Chupp, MD, on his team's research titled "Bronchial Thermoplasty in Patients with Severe Asthma at 5 years: Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma Study. (consultant360.com)
- Bronchial thermoplasty in patients with severe asthma at 5 years: the Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty In Severe Persistent Asthma study. (consultant360.com)
- Before we begin discussing the recent article in Chest, can you please set the stage for many of our listeners regarding the background on the proposed mechanism as to how bronchial thermoplasty came about and why it may be effective in patients with severe refractory asthma. (consultant360.com)
- Consequently, the acute effects of both inhaled marijuana smoke and oral delta-9-THC on specific airway conductance (SGaw) were investigated in a group of patients with clinically stable bronchial asthma. (420magazine.com)
- In patients with bronchial asthma, their airways contract too much and too simply when a trigger is introduced. (culhost.com)
- All patients should be tested regularly with a bronchodilator (e.g. at the annual assessment) to determine if bronchial lability is present. (cysticfibrosis.online)
- Thus, the Ventolin inhaler is the first-line therapy for the relief of an acute attack of suffocation in patients suffering from bronchial asthma, regardless of their age, concomitant diseases, as well as the form and severity of asthma. (vcu-ntc.org)
- Patients with bronchial asthma or bronchitis have the next 'bronchial hyperreactivity', which implies they're extra prone to have a extreme disaster induced by any exterior stimuli, together with substances emitted by cotton wool and heated plastic", reinforces Sabara Hospital's emergency room coordinator. (herouf.com)
Reversible2
- Its hallmark pathophysiologic features are widespread, reversible narrowing of the bronchial airways and a marked increase in bronchial responsiveness to inhaled stimuli. (mhmedical.com)
- Classically COPD is certainly a heterogeneous condition seen as a incompletely reversible air flow blockage including emphysema chronic bronchitis and bronchial hyperreactivity frequently in mixture. (dansukyoshitsu-park.com)
Tubes1
- And in the process of the body trying to defend itself, some damage and changes occur in the tissues of the bronchial tubes. (aarogya.com)
Cough3
- Evaluation of 10,116 firefighters showed exposure-related increases in cough and bronchial hyperreactivity. (cdc.gov)
- The high alkalinity of WTC dust produced bronchial hyperreactivity, persistent cough, and increased risk of asthma. (cdc.gov)
- Cough & bronchial responsiveness in firefighters at the World Trade Center site. (cdc.gov)
Eosinophils1
- Transgenic mice engineered to overexpress human Gal10 in eosinophils (GALILEO mice) had enhanced features of asthma including mucus plugging and bronchial hyperreactivity. (cam.ac.uk)
Persistent2
- Bronchial Thermoplasty in Severe Persistent Asthma: Critical Observations in Pulmonary Medicine, Ep. (consultant360.com)
- Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma study, to be with us today. (consultant360.com)
Allergic3
- In some cases of non-allergic bronchial asthma, the reason for the situation is mediated by the central nervous system dysfunction that leads to a narrowing of the airway. (culhost.com)
- Bronchial challenge tests may be used to assess airway reactions to specific allergens and other sensitizing agents and also to quantify non-allergic airway responsiveness to pharmacological agents such as methacholine or histamine. (sch.ac.kr)
- The danger of smoking is extra pronounced in sufferers with allergic rhinitis and bronchial asthma, the illness is extra widespread in younger individuals, in addition to in instances of pulmonary emphysema, similar to COPD is fashionable ( Chronic obstructive pulmonary illness ), in individuals over 40 years of age, particularly with elevated danger of disaster and hospitalization, as we noticed in sufferers when uncovered throughout fires throughout the nation", he says. (herouf.com)
Chronic2
- IMSEAR at SEARO: Bronchial hyperreactivity in chronic obstructive airways disease. (who.int)
- Asthma is a chronic inflammatory disease of the whole bronchial tree. (biomedcentral.com)
Emphysema1
- Phenotypes of COPD could be additional classified based on radiographic results (i.e the existence or lack of emphysema and/or bronchial wall structure thickening) or genetic Dabigatran etexilate polymorphisms. (dansukyoshitsu-park.com)
Reduction1
- This reduction in hyperreactivity (excessive sensitivity) makes the medication useful as a preventative treatment. (nmihi.com)
Inflammatory1
- Intraperitoneal treatment with α-T-13'-COOH reduced OVA-induced airway hyperreactivity (AHR) as well as peri-bronchial inflammatory cell infiltration. (unisa.it)
Methacholine4
- Bronchial activity was tested at baseline, at nine months, and at three-and-a-half years using a methacholine inhalation challenge. (clinicaltrials.gov)
- This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. (ersjournals.com)
- This report focuses on general considerations for bronchial challenge testing, then specifically on the performance of the methacholine challenge test (MCT). (ersjournals.com)
- airway hyperreactivity is also a specific term that means that the airways are hyperreactive to a variety of stimuli including methacholine, histamine, hypertonic saline, distilled water, exercise, or eucapnic hyperventilation (4). (ancientvalue.com)
Stimuli1
- Broncho-constriction results from contraction of bronchial smooth muscle induced by a myriad possible stimuli, including intrinsic factors, allergens, exercise, stress, or cold air (Table 3.1). (onlineanesthesiatools.com)
Airways disease1
- 2. asthma is a form of reactive airways disease in that it exhibits hyperreactivity to substances like those mentioned above, but reactive airways disease as a phrase refers to other, less well-defined conditions. (ancientvalue.com)
Spasm1
- The immediate stage, i.e. the initial response, occurs suddenly and is due chiefly to spasm of the bronchial smooth musculus. (lyceecharlesdegaulle.eu)
Severity2
- It may help reduce the severity of IPF and protect against bronchial constrictions. (cowurine.com)
- A chart of the twice daily peak expiratory flow rates may be a useful method of measuring the severity of bronchial lability (difference between the best and the worst values) and monitoring the effects of any new treatment. (cysticfibrosis.online)
Pollution1
- Comparison between two districts of the effects of an air pollution intervention on bronchial responsiveness in primary school children in Hong Kong. (bmj.com)
Acute1
- SUMMARY: The acute effects of smoked 2 per cent natural marijuana (7 mg per kg) and 15 mg of oral delta-9-tetrahydrocannabinol (THC) on plethysmographically determined airway resistance (Raw) and specific airway conductance (SGaw) were compared with those of placebo in 10 subjects with stable bronchial asthma using a double-blind crossover technique. (420magazine.com)
Involves1
- This level of bronchial asthma involves frequent nighttime and daytime flare-ups, and often require medicines to keep signs at bay. (culhost.com)