Sneezing
Fatal cold medication intoxication in an infant. (1/10)
The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented. Concentrations of brompheniramine and dextromethorphan were measured in both postmortem blood and liver specimens using a gas chromatograph equipped with a nitrogen-phosphorus detector. Brompheniramine and dextromethorphan were 0.40 mg/L and 0.50 mg/L, respectively, in the blood sample and 0.16 mg/kg and 0.57 mg/kg in the liver sample. The concentration of pseudoephedrine in blood and liver specimens was measured using gas chromatography-mass spectrometry and was determined to be 14.4 mg/L in the blood and 16 mg/kg in the liver. Additionally, a baby bottle allegedly administered to the infant was collected as evidence and sent to the Medical Examiner's Office for evaluation. The amounts of total brompheniramine, dextromethorphan, and pseudoephedrine remaining in the baby bottle were 1.4 mg, 9.4 mg, and 40 mg, respectively. (+info)Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema. (2/10)
Acute ultraviolet light B (UVB) injury is associated with dermal mast cell histamine release. The possibility that histamine-stimulated prostaglandin (PG) synthesis could be a mechanism for irradiation erythema was therefore examined using human skin explants. Explants responded to UV irradiation (120 mJ/cm2) with a fivefold increase in synthesis of prostaglandins E2, F2 alpha and 6-keto PGF1 alpha. Incubating explants with the H1 antihistamines brompheniramine (50 microM) or pyrilamine (30 microM) inhibited PG release from irradiated explants 63 +/- 4.9% (mean +/- SEM) 6 h after UV exposure. Antihistamines did not affect PG synthesis in control explants. Irradiation increased the histamine concentration in explant conditioned medium only 50% over basal values, suggesting that irradiation enhanced histamine responsiveness. Explants were therefore incubated with exogenous histamine. In irradiated explants, PG synthesis was stimulated threefold by 3 microM histamine. Unirradiated explants' PG synthesis was unaffected by histamine. Enhanced histamine sensitivity was also examined in epidermal cell cultures. In irradiated cultures, histamine sensitivity was again markedly potentiated: as little as 1 microM histamine stimulated significant PGE2 release and the response to 10-30 microM histamine was increased six to eight times compared with that of unirradiated cultures. These studies demonstrate that endogenous histamine stimulates PG synthesis in human skin after UV injury by potentiation of histamine-induced prostaglandin release. Potentiated agonist responses induced by UV exposure may contribute to the effects of UVB irradiation injury and in particular to irradiation erythema. (+info)Surface degradation of composite resins by acidic medicines and pH-cycling. (3/10)
(+info)Muscarinic cholinergic binding in rat brain. (4/10)
Binding sites with high affinity and specificity for [(3)H]quinuclidinyl benzilate (QNB) are present in homogenates of rat brain. The characteristics of the binding sites resemble those of muscarinic cholinergic receptors. Specific binding is saturable with respect to [(3)H]QNB and tissue concentration and is time-, temperature-, and pH-dependent. The bimolecular rate of association (2.0 x 10(8) M(-1) min(-1)) and dissociation (1.2 x 10(-2) min(-1)) at 35 degrees indicate a dissociation constant of 60 pM and a density of 65 pmol/g of brain. Muscarinic antagonists and agonists displace specific [(3)H]QNB binding, while nicotinic and non-cholinergic drugs possess little affinity for [(3)H]QNB-binding sites. (+info)Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man. (5/10)
1 Effects of brompheniramine maleate (4 and 12 mg) and triprolidine hydrochloride (2.5 and 10 mg) on visuo-motor coordination, and on subjective assessments of performance, well-being and sleep were each studied in six subjects at 0.5, 1.5, 3.0, 5.0 and 7.0 h after ingestion. The doses refer to immediate and sustained release preparations respectively. 2. Triprolidine hydrochloride (2.5 mg) had an immediate effect on performance which persisted to 3.0 h, and the sustained release preparation (10 mg) impaired performance from 1.5 to 5.0 h. Brompheniramine maleate (4 mg) impaired performance from 1.5 to 3.0 h, and the sustained release preparation (12 mg) impaired performance at 1.5 h. There were no consistent changes in the subjective assessments of performance, or of well-being and sleep. 3. The studies emphasize the variable effects of antihistamines on performance, and suggest that effects on performance of sustained release preparations may be similar to those of the usual form. Sustained release preparations may provide an advantage in clinical practice if the antihistaminic activity is prolonged. (+info)Event recording in a clinical trial of a new medicine. (6/10)
In a double-blind trial of the effect of zimelidine on weight and appetite 24 obese patients were allocated at random to receive either zimelidine or placebo for eight weeks followed by the alternative treatment for eight weeks. Possible adverse effects were elicited by asking patients at weekly intervals whether they had experienced any symptoms or ailments and recording all such "events" on a special form. A conventional checklist of symptoms was also used. Among 19 patients who completed the trial the two methods of recording yielded similar patterns of events. Of symptoms not on the checklist, insomnia was more common during treatment with zimelidine. Event recording was found to be a practicable and convenient method of detecting possible adverse effects. (+info)Attenuation of pethidine-induced antinociception by zimelidine, an inhibitor of 5-hydroxytryptamine reuptake. (7/10)
1 The effect of selective inhibition of 5-hydroxytryptamine (5-HT) re-uptake by fluoxetine and zimelidine on morphine- and pethidine-induced antinociception was studied in rats. The hot plate (55 degrees C) and tail flick test procedures for measurement of analgesia were employed to assess antinociception. 2 Pretreatment with fluoxetine and zimelidine potentiated the antinociceptive effect of morphine (4.5 mg/kg, as base); zimelidine was without effect on a lesser dose of morphine (3.0 mg/kg, as base). 3 Pretreatment with zimelidine but not fluoxetine, significantly attenuated pethidine-induced antinociception (24 mg/kg, as base) and prevented the expression of pethidine-induced antinociception at a lesser 10 mg/kg (as base) dose of pethidine. 4 These and other results support (a) a role for 5-HT in the expression of morphine-induced antinociception, and (b) a different mode of antinociceptive action of morphine and pethidine. The role of 5-HT in pethidine-induced antinociception remains unclear. (+info)Differences in performance impairment due to brompheniramine maleate as a function of the sustained-release system. (8/10)
1 study examined whether different sustained release systems would cause variation in the effect of an antihistamine, brompheniramine maleate 10 mg, upon mood and psychomotor performance. Two commercial preparations were examined, one giving linear release (LR) of the drug over time, the other releasing the drug in a non-linear fashion (NLR). 2 Thirty-six males were allocated to four separate groups receiving either the drug with LR, drug with NLR, placebo or drug-free control. Single dosage of the drug occurred at 08.30 h and subjects completed mood inventories and performed serial choice reaction time and visual search tasks at 1 h, 2.75 h, 5.5 h and 7.25 h post dosage. 3 The NLR system significantly increased feelings of unco-ordination at 2.75 h and significantly slowed reaction time at both 2.75 and 5.5 h post dosage. The LR system significantly slowed reaction time only at 5.5 h but increased pausing in serial choice performance at that time. Neither system impaired visual search. 4 Results suggest that two preparations having identical active constituents may vary in their effects on psychomotor performance and mood as a function of their sustained release systems. A system giving linear release of the drug can reduce the early post-dosage performance decrement associated with a non-linear release system. (+info)Brompheniramine is a medication that is used to treat symptoms of allergies and the common cold, such as runny nose, sneezing, and itchy eyes. It is a type of antihistamine, which works by blocking the action of histamine, a chemical that is produced by the body in response to an allergic reaction or the common cold. Brompheniramine is available over-the-counter (OTC) in various forms, including tablets, capsules, and liquids. It is also available by prescription in higher strengths or in combination with other medications. It is important to follow the instructions on the label or as directed by your healthcare provider when taking brompheniramine.
In the medical field, sneezing is a reflex action of the respiratory system that expels air from the lungs through the nose or mouth. It is a protective mechanism that helps to clear the nasal passages of irritants, such as dust, pollen, or viruses, and prevent them from entering the lungs. Sneezing is triggered by the irritation of the nasal passages, which sends a signal to the brain to initiate the sneeze reflex. The muscles in the chest, abdomen, and diaphragm contract, forcing air out of the lungs at a high velocity. This can cause the eyes to water, the nose to run, and the ears to pop. While sneezing is generally a normal and harmless response, it can sometimes be a symptom of an underlying medical condition, such as a cold, allergies, or a respiratory infection. In some cases, excessive or persistent sneezing may require medical attention.
The common cold is a viral infection that affects the upper respiratory tract, including the nose, throat, and sinuses. It is caused by a variety of viruses, including rhinoviruses, coronaviruses, and adenoviruses. The common cold is highly contagious and can be spread through contact with infected individuals or surfaces contaminated with the virus. Symptoms of the common cold typically include a runny or stuffy nose, sore throat, cough, and sometimes fever, body aches, and headaches. The common cold is a self-limiting illness, meaning that it will usually resolve on its own within a week or two without the need for medical treatment. However, over-the-counter medications such as pain relievers, decongestants, and cough suppressants can help alleviate symptoms.
Brompheniramine
Cold medicine
Dexbrompheniramine
Pheniramine
Cunninghamella elegans
List of accidents and incidents involving military aircraft (1980-1989)
BPP
Chlorphenamine
Muscarinic antagonist
H1 antagonist
Diphenhydramine
Arvid Carlsson
Zimelidine
PPPA (drug)
Hydromorphone
May 1981
Sedative
List of MeSH codes (D03)
Dimetapp
C16H19BrN2
Development and discovery of SSRI drugs
ATC code R06
Osmotic-controlled release oral delivery system
List of drugs: Br
Antihistamine
Dihydrocodeine
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Chlorpheniramine4
- Brompheniramine is part of a series of antihistamines including pheniramine (Naphcon) and its halogenated derivatives and others including fluorpheniramine, chlorpheniramine, dexchlorpheniramine (Polaramine), triprolidine (Actifed), and iodopheniramine. (wikipedia.org)
- Brompheniramine is an analog of chlorpheniramine. (wikipedia.org)
- chlorpheniramine (Chlor-Trimeton) and brompheniramine (Dimetane). (wikidoc.org)
- These include brompheniramine, chlorpheniramine (Chlor-Trimeton), and diphenhydramine (Benadryl). (medscape.com)
Maleate4
- brompheniramine products contain racemic brompheniramine maleate, whereas dexbrompheniramine (Drixoral) is the dextrorotary (right-handed) stereoisomer. (wikipedia.org)
- Brompheniramine and brompheniramine maleate are the poisonous ingredients in this medicine. (medlineplus.gov)
- Brompheniramine ( Bromfed , Dimetapp , Bromfenex , Dimetane , BPN , Lodrane ), commonly marketed as its salt brompheniramine maleate is an antihistamine drug of the propylamine (alkylamine) class. (curecrowd.com)
- The halogenated alkylamine antihistamines all exhibit optical isomerism and brompheniramine products contain racemic brompheniramine maleate whereas dexbrompheniramine (Drixoral) is the dextrorotary (right-handed) stereoisomer. (curecrowd.com)
Allergic to brompheniramine1
- tell your doctor and pharmacist if you are allergic to brompheniramine, any other medications, or any of the ingredients in brompheniramine preparations. (medlineplus.gov)
Antihistamines1
- Brompheniramine is in a class of medications called antihistamines. (medlineplus.gov)
Pseudoephedrine5
- brompheniramine, codeine, and pseudoephedrine will not treat a cough that is caused by smoking , asthma , or emphysema . (drugs.com)
- Brompheniramine, codeine, and pseudoephedrine may also be used for purposes not listed in this medication guide. (drugs.com)
- How should I take brompheniramine, codeine, and pseudoephedrine? (drugs.com)
- Brompheniramine, dextromethorphan, and pseudoephedrine can cause side effects that may impair your thinking or reactions. (health32.com)
- Brompheniramine, dextromethorphan, and pseudoephedrine can pass into breast milk and may harm a nursing baby. (health32.com)
Antihistamine3
- Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. (wikipedia.org)
- Brompheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. (drugs.com)
- Brompheniramine is a type of medicine called an antihistamine, which helps relieve allergy symptoms. (medlineplus.gov)
Medication1
- Before you give a brompheniramine product to a child, check the package label to find out how much medication the child should receive. (medlineplus.gov)
Medications2
- Brompheniramine comes in combination with other cough and cold medications as a chewable tablet, an extended-release (long-acting) capsule, an extended-release (long-acting) tablet, and a liquid to be taken by mouth. (medlineplus.gov)
- Brompheniramine comes in combination with other cough and cold medications. (medlineplus.gov)
Cough1
- Nonprescription cough and cold combination products, including products that contain brompheniramine, can cause serious side effects or death in young children. (medlineplus.gov)
Symptoms3
- Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. (medlineplus.gov)
- Stop taking brompheniramine and call your doctor if your symptoms last longer than 7 days or if you have a fever. (medlineplus.gov)
- Below are symptoms of a brompheniramine overdose in different parts of the body. (medlineplus.gov)
Products1
- Do not give brompheniramine products that are made for adults to children. (medlineplus.gov)
Medicine1
- Brompheniramine overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
Product1
- If you are giving a product that contains brompheniramine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)
Effects4
- isocarboxazid increases effects of brompheniramine by Other (see comment). (medscape.com)
- brompheniramine decreases effects of pitolisant by Other (see comment). (medscape.com)
- tranylcypromine increases effects of brompheniramine by Other (see comment). (medscape.com)
- What are the possible side effects of AccuHist PDX Drops (Brompheniramine/Dextromethorphan/Pse)? (health32.com)
Important1
- What is the most important information I should know about AccuHist PDX Drops (Brompheniramine/Dextromethorphan/Pse)? (health32.com)
Dimetapp2
- Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. (wikipedia.org)
- Synthetic drugs brompheniramine ( Dimetapp) & terfenadine ( Seldane), act as antihistamines. (theknowledgelibrary.in)
Allergy2
- Brompheniramine is a type of medicine called an antihistamine, which helps relieve allergy symptoms. (nih.gov)
- Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking brompheniramine without first talking to your pharmacist or doctor. (health32.com)
Interact with brompheniramine1
- Drugs other than those listed here may also interact with brompheniramine. (health32.com)
Take brompheniramine5
- Take brompheniramine exactly as directed. (medlineplus.gov)
- Do not take brompheniramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. (health32.com)
- You may not be able to take brompheniramine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. (health32.com)
- Do not take brompheniramine without first talking to your doctor if you are pregnant or could become pregnant during treatment. (health32.com)
- Do not take brompheniramine without first talking to your doctor if you are nursing a baby. (health32.com)
Doctor and pharmacist1
- tell your doctor and pharmacist if you are allergic to brompheniramine, any other medications, or any of the ingredients in brompheniramine preparations. (medlineplus.gov)
Drugs2
- What other drugs affect Lodrane 24 (Brompheniramine)? (health32.com)
- Other medications may also contain brompheniramine or other similar drugs, and you may accidentally take too much of these medicines. (health32.com)
Lodrane4
- What is the most important information I should know about Lodrane 24 (Brompheniramine)? (health32.com)
- What should I discuss with my healthcare provider before taking Lodrane 24 (Brompheniramine)? (health32.com)
- What are the possible side effects of Lodrane 24 (Brompheniramine)? (health32.com)
- What should I avoid while taking Lodrane 24 (Brompheniramine)? (health32.com)
Sleepiness1
- Brompheniramine should not be used to cause sleepiness in children. (medlineplus.gov)
Anticholinergic1
- Brompheniramine also has anticholinergic (drying) and sedative effects. (nih.gov)
Chew1
- Do not crush, chew, or break the extended- or timed-release forms of brompheniramine. (health32.com)
Liver1
- Brompheniramine is metabolised by cytochrome P450 isoenzymes in the liver. (wikipedia.org)
Sedation1
- brompheniramine and olopatadine intranasal both increase sedation. (medscape.com)
Increase1
- Alcohol may increase drowsiness and dizziness while taking brompheniramine. (health32.com)