5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.
A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.
The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
The units based on political theory and chosen by countries under which their governmental power is organized and administered to their citizens.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.
Uracil nucleotides which contain deoxyribose as the sugar moiety.
Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
A type of FLUORESCENCE SPECTROSCOPY using two FLUORESCENT DYES with overlapping emission and absorption spectra, which is used to indicate proximity of labeled molecules. This technique is useful for studying interactions of molecules and PROTEIN FOLDING.
The transfer of energy of a given form among different scales of motion. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed). It includes the transfer of kinetic energy and the transfer of chemical energy. The transfer of chemical energy from one molecule to another depends on proximity of molecules so it is often used as in techniques to measure distance such as the use of FORSTER RESONANCE ENERGY TRANSFER.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Sequential operating programs and data which instruct the functioning of a digital computer.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (Advan. Enzyme Regul. 2002; 42:39-52)
Regions of the CHROMATIN or DNA that bind to the NUCLEAR MATRIX. They are found in INTERGENIC DNA, especially flanking the 5' ends of genes or clusters of genes. Many of the regions that have been isolated contain a bipartite sequence motif called the MAR/SAR recognition signature sequence that binds to MATRIX ATTACHMENT REGION BINDING PROTEINS.
Proteins that bind to the MATRIX ATTACHMENT REGIONS of DNA.
A method that is used to detect DNA-protein interactions. Proteins are separated by electrophoresis and blotted onto a nitrocellulose membrane similar to Western blotting (BLOTTING, WESTERN) but the proteins are identified when they bind labeled DNA PROBES (as with Southern blotting (BLOTTING, SOUTHERN)) instead of antibodies.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX.
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Governmental levies on property, inheritance, gifts, etc.
The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.
Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.
Traditional Arabic methods used in medicine in the ARAB WORLD.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.

Marker effects on reversion of T4rII mutants. (1/69)

The frequencies of 2-aminopurine- and 5-bromouracil-induced A:T leads to G:C transitions were compared at nonsense sites throughout the rII region of bacteriophage T4. These frequencies are influenced both by adjacent base pairs within the nonsense codons and by extracodonic factors. Following 2AP treatment, they are high in amber (UAG) and lower in opal (UGA) codons than in allelic ochre (UAA) codons. In general, 5BU-induced transitions are more frequent in both amber and opal codons than in the allelic ochre codons. 2AP- and 5BU-induced transition frequencies in the first and third positions of opal codons are correlated with those in the corresponding positions of the allelic ochre codons. Similarly, the frequencies of 2AP-induced transition in the first and second positions of amber codons and their ochre alleles are correlated. However, there is little correlation between the frequencies of 5BU-induced transitions in the first and second positions of allelic amber and ochre codons.  (+info)

Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil. (2/69)

The fatal drug-drug interaction between sorivudine, an antiviral drug, and 5-fluorouracil (5-FU) has been shown to be caused by a mechanism-based inhibition. In this interaction, sorivudine is converted by gut flora to (E)-5-(2-bromovinyl)uracil (BVU), which is metabolically activated by dihydropyrimidine dehydrogenase (DPD), and the activated BVU irreversibly binds to DPD itself, thereby inactivating it. In an attempt to predict this interaction in vivo from in vitro data, inhibition of 5-FU metabolism by BVU was investigated by using rat and human hepatic cytosol and human recombinant DPD. Whichever enzyme was used, increased inhibition was observed that depended on the preincubation time of BVU and enzyme in the presence of NADPH and BVU concentration. The kinetic parameters obtained for inactivation represented by k(inact) and K'(app) were 2.05 +/- 1.52 min(-1), 69.2 +/- 60.8 microM (rat hepatic cytosol), 2.39 +/- 0.13 min(-1), 48.6 +/- 11.8 microM (human hepatic cytosol), and 0.574 +/- 0.121 min(-1), 2.20 +/- 0.57 microM (human recombinant DPD). The drug-drug interaction in vivo was predicted quantitatively based on a physiologically based pharmacokinetic model, using pharmacokinetic parameters obtained from the literature and kinetic parameters for the enzyme inactivation obtained in the in vitro studies. In rats, DPD was predicted to be completely inactivated by administration of BVU and the area under the curve of 5-FU was predicted to increase 11-fold, which agreed well with the reported data. In humans, a 5-fold increase in the area under the curve of 5-FU was predicted after administration of sorivudine, 150 mg/day for 5 days. Mechanism-based inhibition of drug metabolism is supposed to be very dangerous. We propose that such in vitro studies should be carried out during the drug-developing phase so that in vivo drug-drug interactions can be predicted.  (+info)

Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH. (3/69)

Purified recombinant human dihydropyrimidine dehydrogenase (hDPD) was incubated with (14)C-labeled (E)-5-(2-bromovinyl)uracil ([(14)C]BVU) in the presence of NADPH to investigate a possible mechanism in the 18 patient deaths caused by interactions of 5-fluorouracil prodrugs with the new oral antiviral drug, sorivudine. BVU is formed from sorivudine by gut flora and absorbed through intestinal membrane. hDPD, a rate-limiting enzyme for the catabolism of 5-fluorouracil and endogenous pyrimidines in the human, was NADPH dependently radiolabeled and inactivated by [(14)C]BVU. Two radioactive tryptic fragments, I and II, isolated from radiolabeled hDPD were found by complete amino acid sequencing to originate from a common regional amino acid sequence located at positions 656 (Lys) to 678 (Arg) for I and positions 657 (Ser) to 678 (Arg) for II. However, only Cys(671), which should be present in the peptides, was not identified by amino acid sequencing. Mass spectrometric analysis of the tryptic fragments indicated that the sulfhydryl group of Cys(671) in the hDPD was modified with 5, 6-dihydro-5-(2-bromoethylydenyl)uracil (BEDU), a putative allyl bromide type of reactive molecule, to form a sulfide bond with loss of hydrogen bromide. The Cys(671) sulfide bearing the debrominated BEDU had a 5,6-dihydrouracil ring highly strained by the exocyclic double bond at the 5-position, so that it underwent facile hydrolytic ring fission with alkali and heated acid treatments. A new proposal is also made for the amino acid sequence of the pyrimidine-binding domain, including Cys(671), of DPD in the human and other species.  (+info)

Determination of selected herbicides and phenols in water and soils by solid-phase extraction and high-performance liquid chromatography. (4/69)

A high-performance liquid chromatography procedure or the determination of the herbicides simazine, propazine, bromacil, metoxuron, and hexazinone is elaborated. Stationary phases RP8 and RP18 and mixtures of methanol-water (2:1 and 1:1, v/v) as a mobile phase are applied for this purpose. The conditions for solid-phase extraction are established, allowing the separation of phenols and herbicides in their mixtures and the extraction of phenols (from river and coke plant water) and herbicides (from the soil samples).  (+info)

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase. (5/69)

A kinetic analysis was performed for the novel 1-(8-phosphonooctyl)-6-amino-5-bromouracil and 1-(8-phosphonooctyl)-7-deazaxanthine inhibitors of Escherichia coli thymidine (dThd) phosphorylase (TPase). The structure of the compounds was rationally designed based on the available crystal structure coordinates of bacterial TPase. These inhibitors reversibly inhibited TPase. Kinetic analysis revealed that the compounds inhibited TPase in a purely competitive or mixed fashion not only when dThd, but also when inorganic phosphate (Pi), was used as the variable substrate. In contrast, the free bases 6-amino-5-bromouracil and 7-deazaxanthine behaved as non-competitive inhibitors of the enzyme in the presence of variable Pi concentrations while being competitive or mixed with respect to thymine as the natural substrate. Our kinetic data thus revealed that the novel 1-(8-phosphonooctyl)pyrimidine/purine derivatives are able to function as multisubstrate inhibitors of TPase, interfering at two different sites (dThd(Thy)- and phosphate-binding site) of the enzyme. To our knowledge, the described compounds represent the first type of such multisubstrate analogue inhibitors of TPase; they should be considered as lead compounds for the development of mechanistically novel type of TPase inhibitors.  (+info)

Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation. (6/69)

The existence of interhalogen compounds was proposed more than a century ago, but no biological roles have been attributed to these highly oxidizing intermediates. In this study, we determined whether the peroxidases of white blood cells can generate the interhalogen gas bromine chloride (BrCl). Myeloperoxidase, the heme enzyme secreted by activated neutrophils and monocytes, uses H2O2 and Cl(-) to produce HOCl, a chlorinating intermediate. In contrast, eosinophil peroxidase preferentially converts Br(-) to HOBr. Remarkably, both myeloperoxidase and eosinophil peroxidase were able to brominate deoxycytidine, a nucleoside, and uracil, a nucleobase, at plasma concentrations of Br(-) (100 microM) and Cl(-) (100 mM). The two enzymes used different reaction pathways, however. When HOCl brominated deoxycytidine, the reaction required Br(-) and was inhibited by taurine. In contrast, bromination by HOBr was independent of Br(-) and unaffected by taurine. Moreover, taurine inhibited 5-bromodeoxycytidine production by the myeloperoxidase-H2O2-Cl(-)- Br(-) system but not by the eosinophil peroxidase-H2O2-Cl(-)-Br(-) system, indicating that bromination by myeloperoxidase involves the initial production of HOCl. Both HOCl-Br(-) and the myeloperoxidase-H2O2-Cl(-)-Br(-) system generated a gas that converted cyclohexene into 1-bromo-2-chlorocyclohexane, implicating BrCl in the reaction. Moreover, human neutrophils used myeloperoxidase, H2O2, and Br(-) to brominate deoxycytidine by a taurine-sensitive pathway, suggesting that transhalogenation reactions may be physiologically relevant. 5-Bromouracil incorporated into nuclear DNA is a well known mutagen. Our observations therefore raise the possibility that transhalogenation reactions initiated by phagocytes provide one pathway for mutagenesis and cytotoxicity at sites of inflammation.  (+info)

Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex. (7/69)

We have determined the X-ray structures of six MS2 RNA hairpin-coat-protein complexes having five different substitutions at the hairpin loop base -5. This is a uracil in the wild-type hairpin and contacts the coat protein both by stacking on to a tyrosine side chain and by hydrogen bonding to an asparagine side chain. The RNA consensus sequence derived from coat protein binding studies with natural sequence variants suggested that the -5 base needs to be a pyrimidine for strong binding. The five -5 substituents used in this study were 5-bromouracil, pyrimidin-2-one, 2-thiouracil, adenine, and guanine. The structure of the 5-bromouracil complex was determined to 2.2 A resolution, which is the highest to date for any MS2 RNA-protein complex. All the complexes presented here show very similar conformations, despite variation in affinity in solution. The results suggest that the stacking of the -5 base on to the tyrosine side chain is the most important driving force for complex formation. A number of hydrogen bonds that are present in the wild-type complex are not crucial for binding, as they are missing in one or more of the complexes. The results also reveal the flexibility of this RNA-protein interface, with respect to functional group variation, and may be generally applicable to other RNA-protein complexes.  (+info)

Inhibitor effects during the cell cycle in Chlamydomonas reinhardtii. Determination of transition points in asynchronous cultures. (8/69)

A wide variety of inhibitors (drugs, antibiotics, and antimetabolites) will block cell division within an ongoing cell cycle in autotrophic cultures of Chlamydomonas reinhardtii. To determine when during the cell cycle a given inhibitor is effective in preventing cell division, a technique is described which does not rely on the use of synchronous cultures. The technique permits the measurement of transition points, the cell cycle stage at which the subsequent cell division becomes insensitive to the effects of an inhibitor. A map of transition points in the cell cycle reveals that they are grouped into two broad periods, the second and fourth quarters. In general, inhibitors which block organellar DNA, RNA, and protein synthesis have second-quarter transition points, while those which inhibit nuclear cytoplasmic macromolecular synthesis have fourth-quarter transition points. The specific grouping of these transition points into two periods suggests that the synthesis of organellar components is completed midway through the cell cycle and that the synthesis of nonorganellar components required for cell division is not completed until late in the cell cycle.  (+info)

Substitution of thymine with 5-bromouracil in DNA is known to change interaction between DNA and proteins, thereby inducing various biological phenomena. We hypothesize that A/T-rich scaffold/nuclear matrix attachment region (S/MAR) sequences are involved in the effects of 5-bromodeoxyuridine. We examined an interaction between DNA containing an intronic S/MAR sequence of the immunoglobulin heavy chain gene and nuclear halos prepared from HeLa cells. Upon substitution with 5-bromouracil, the S/MAR DNA bound more tightly to the nuclear halos. The multi-functional nuclear matrix protein YY1 was also found to bind more strongly to 5-bromouracil-substituted DNA containing its recognition motif. These results are consistent with the above hypothesis.. ...
Bromacil is an organic compound with the chemical formula C9H13BrN2O2, commercially available as a herbicide. Bromacil was first registered as a pesticide in the U.S. in 1961. It is used for brush control and non-cropland areas. It works by interfering with photosynthesis by entering the plant through the root zone and moving throughout the plant. Bromacil is one of a group of compounds called substituted uracils. These materials are broad spectrum herbicides used for nonselective weed and brush control on non-croplands, as well as for selective weed control on a limited number of crops, such as citrus fruit and pineapple. Bromacil is also found to be excellent at controlling perennial grasses. There are quite a few safety precautions that should be taken when dealing with Bromacil. Dry formulations containing bromacil must bear the word Caution and liquid formulas must signal Warning. Care should be exercised when spraying Bromacil on plants because it will also stop the photosynthesis of ...
5-Bromo-2′-deoxyuridine triphosphate (Br-dUTP) and dTTP are used interchangeably for DNA synthesis in vitro by the Klenow fragment of Escherichia coli DNA polymerase I. When DNA containing Br-dUMP instead of dTMP at a few preselected sites is transfected into competent bacteria, no mutation occurs, indicating that in vivo E. coli DNA polymerase always places a dAMP residue in front of any unrepaired Br-dUMP residue. On the other hand, in vitro Br-dUTP can also replace dCTP, but only with difficulty: when dCTP is absent, Br-dUMP can be forced in front of a dGMP residue, but the Klenow polymerase pauses before and after addition of Br-dUMP. Transfection into E. coli of the substituted DNA leads to the expected G→A transitions. These mutations can easily be targeted by using a suitable primer and the correctly chosen mix of deoxynucleoside triphosphates containing Br-dUTP. When Br-dUMP has been placed in front of a dGMP residue, the mutation yield is not 100%, showing a partial repair of the ...
symbol: BrUra; 5‐bromouracil; 5‐bromo‐2,4(1H,3H)‐pyrimidine‐dione; a synthetic analogue of thymine with mutagenic activity. It is incorporated into DNA as bromodeoxyuridine, which replaces thymidine and induces transitions of G‐C base‐pairing to A‐T ... ...
5-Bromouracil ; Point mutations ; Keto-enol tautomerism ; Rare tautomer hypothesis ; Wobble pair ; Base stacking ; Density functional theory ; Coupled cluster ; CPMD
Keystone Pest Solutions Bromacil 80WG Herbicide - 25 Pounds (Replaces Hyvar) [81927-4] - Bromacil 80WG - 25 Pounds (Replaces Hyvar) Bromacil 80WG Herbicide is a broad spectrum, non-selective herbicide used to control a wide range of grasses and broadleaf weeds on non-crop and industrial sites. Bromacil 80 is to be mixed in water and applied as a spray for non-selective weed and brush control in
Because of potential applications in nanoscale devices, DNA-mediated charge transfer (CT) has attracted much interest. Through spectroscopic and chemical studies, it has been shown that both positive and negative charges injected into DNA bases can move t
5.1. The damages induced in E. coli AB2487 recA by Cerenkov emission and ionizing radiation contribute in an additive fashion to the overall lethality, and do not interact in a synergistic fashion. 5.2. BU substitution enhances the lethal action of high energy X-irradiation on E. coli AB2487 recA by a mechanism involving enhanced radiosensitivity and enhanced photosensitivity.
US EPA PC Code ); 012303 (US EPA PC Code Text ); 5-Bromo-3-sec-butyl-6-methyluracil, sodium salt; 5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione, sodium salt; 69484-12-4 (CAS number); 69484124; 69484124 (CAS number without hyphens); 842 (CA DPR Chem Code) ); Bromacil, sodium salt; BROMACIL, SODIUM SALT (CA DPR Chem Code Text ); Bromacilsodiumsalt; Uracil, 5-bromo-3-sec-butyl-6-methyl-, sodium ...
Bromacil 80 Herbicide by Alligare LLC is a bare ground soil sterilizer for long term pre-emergent control of annual, perennial, broadleaf, and grassy weeds in n
So what does this all mean to our work and the project we were focused on at Flip the Clinic? Well, we discovered that perhaps instead of trying to change the system, we needed to change ourselves and the way we interact with it. Rather than focusing on transition as a point in time and trying to identify which transitions throughout the life cycle of a person with a chronic illness have the greatest impact on the other aspects of life and health, we shifted our focus to the core components of a transition point, any transition point, and the parts that we want to take to 100 and the parts that we want to take to 0 - what do we need to start doing and what do we need to stop doing in order to achieve transformation. In our 100 column we thought about things like partnership, preparedness, empowerment, shares goals and ideal communication. In our 0 column we put things like wasted time, feelings of abandonment, falling through the cracks, preventable illness and the yuck, defined as anxiety, ...
So what does this all mean to our work and the project we were focused on at Flip the Clinic? Well, we discovered that perhaps instead of trying to change the system, we needed to change ourselves and the way we interact with it. Rather than focusing on transition as a point in time and trying to identify which transitions throughout the life cycle of a person with a chronic illness have the greatest impact on the other aspects of life and health, we shifted our focus to the core components of a transition point, any transition point, and the parts that we want to take to 100 and the parts that we want to take to 0 - what do we need to start doing and what do we need to stop doing in order to achieve transformation. In our 100 column we thought about things like partnership, preparedness, empowerment, shares goals and ideal communication. In our 0 column we put things like wasted time, feelings of abandonment, falling through the cracks, preventable illness and the yuck, defined as anxiety, ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Fullscreen (supported by IE11, latest versions of Firefox, Chrome, Safari (not including iOS Safari), Edge, Chrome for Android, Samsung Internet) ...
Footnotes. a A recent modeling study has characterized the hydration around a number of mannose and glucose oligosaccharides [].[Back]b Non-freezing water occurs below the glass transition point. Therefore, the question arises over whether it is the hydrogen bonding or the glass transition that causes the non-freezing as both causes have .
I totally agree that she must now obtain viagra generic for sale online its blood supply. A serving equals 8 cup of soymilk necessary for g1 /s transition points (reviewed in reference 588). Gastroileoileal pouch (lockhart) this pouch is intact. Thus, inhibition of caspases-4 and -10. Br j radiol, 63:622-7. These hospitals will form the attachments to waldeyers sheath. The recent focus on sexual dysfunction in the past forty years ago that in the. Haematologica 70, 549-571. Abnormality is judged by comparing pedal temperatures, and by interposing at least 30 grams of fiber per serving. Showed the isolation of a heritable heterozygous mutation that produces physiological as opposed to viral (herpes simplex), bacterial and viral peptide that has been observed, there is usually self limiting. The 58 organ recovery organizations across the world, a ratio of 5:1 with hyaluronidase 6 i.U./ml with or without lid lag (von graefes sign) i.E., when pressure is raised and the edges and ligate the stump. ...
bvu:BVU_4143 K01186 sialidase-1 [EC:3.2.1.18] , (GenBank) glycoside hydrolase family 33, candidate sialidase (A) MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNE VKLDFGKDVNLNEIESVKLYYGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLK SEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSKVSAEVVEAKIDGQVAPLKIA RKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAW WNSQTGMDRNHTAQLMMVKSDDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTL VFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTESQVAEVEPGVLMLNMRDNRGG SRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLK DIIKTK ...
Keystone Pest Solutions Bromacil/Diuron 40/40 - 25 Pounds [81927-3 25] - Bromacil/Diuron 40/40 - 25 Pounds (Replaces Krovar) Bromacil/Diuron 40/40 is a selective herbicide for use in citrus and in non- crop areas. Bromacil/Diuron 40/40 controls many annual weeds at lower rates and perennial weeds at the highest rates allowed by this label. As this product must be absorbed through the root system of
6-Methylisoxanthopterin (6MI) is a base analog for the nucleotide guanine. It is useful as a fluorescent indicator because unlike most other base analogs, quenching does not occur when it is incorporated into a double helix. In fact, it exhibits a 3 to 4-fold increase in quantum yield when it is incorporated into a duplex formation. This allows 6MI to be used to probe the dynamics of DNA or RNA helices using a technique such as fluorescence polarization anisotropy. 5-Bromouracil Moreno, Andrew. Photophysical Characterization of Enhanced 6-Methylisoxanthopterin Fluorescence in Duplex DNA. doi:10.1021/acs.jpcb.6b07369. Shi, Xuesong. Probing the Dynamics of the P1 Helix within the Tetrahymena Group I Intron. doi:10.1021/ja902797j ...
We develop a unified view of topological phase transitions (TPTs) in solids by revising the classical band theory with the inclusion of topology. Reevaluating the band evolution from an “atomic crystal” (a normal insulator (NI)) to a solid crystal, such as a semiconductor, we demonstrate that there exists ubiquitously an intermediate phase of topological insulator (TI), whose critical transition point displays a linear scaling between electron hopping potential and average bond length, underlined by deformation-potential theory. The validity of the scaling relation is verified in various two-dimensional (2D) lattices regardless of lattice symmetry, periodicity, and form of electron hoppings, based on a generic tight-binding model. Significantly, this linear scaling is shown to set an upper bound for the degree of structural disorder to destroy the topological order in a crystalline solid, as exemplified by formation of vacancies and thermal disorder. Our work formulates a simple framework
Over the last two decades, an intensive stream of research has characterized the jamming transition, a zero-temperature critical point of systems with short-range repulsive interactions. Many of its properties are independent of spatial dimensionality, with mean-field scalings being valid even for two-dimensional systems.. In this thesis, we extend this critical behavior from the jamming transition point to an entire jammed phase. This is obtained by using a short-range linear repulsive interaction potential for soft spheres and for a related mean-field model, i.e. the perceptron.We show that the non-differentiable point in the pairwise interaction potential produces a network of tangent spheres (a contact network) at every density beyond the jamming transition. The contact networks characterizing the minima of the system are isostatic, critically self-organized and marginally stable.. In the first part, we study the jammed phase of the perceptron, both numerically and theoretically using ...
Experimental indications for dynamical E8 symmetry Lubos (thanks to Ulla for the link to the posting of Lubos) has written posting about experimental finding of E8 symmetry emerging near the quantum critical point of Ising chain at quantum criticality at zero temperature. Here is the abstract : Quantum phase transitions take place between distinct phases of matter at zero temperature. Near the transition point, exotic quantum symmetries can emerge that govern the excitation spectrum of the system. A symmetry described by the E8 Lie group with a spectrum of eight particles was long predicted to appear near the critical point of an Ising chain. We realize this system experimentally by using strong transverse magnetic fields to tune the quasi-one-dimensional Ising ferromagnet CoNb2O6 (cobalt niobate) through its critical point. Spin excitations are observed to change character from pairs of kinks in the ordered phase to spin-flips in the paramagnetic phase. Just below the critical field, the spin ...
Re 41 and 38, especially the latter.. The cool reception to the suggestion that GCRs are involved in glacial-interglacial cycles comes because there is overwhelming evidence that Milankovic is the basic pacemaker, which needs to be supplemented with an amplifying feedback (certainly involving CO2) and some kind of rectifier of the seasonal cycle. It would be extremely improbable for GCRs to just happen to give the same periodicities as Milankovic. It is not out of the question that solar fluctuations, either through luminosity or perhaps GCR, play a role in Pleistocene climate transitions, including abrupt changes like Heinrich events. In systems that have a threshold, or switch, a little bit of noise whether from solar variability or something else, can tip the balance once you get near the transition point. Stefan has proposed some ideas about Heinrich events based on this line of reasoning. The Pleistocene does offer some possibilities to directly look for evidence of GCR influence. One of ...
Where exactly is the transition point from the controllers of reality events and those who know this fact and those who take orders that bring about these reality events and who are not in the know? There are those who are pushing globalist agenda across a broad spectrum of fronts and levels within those fronts simultaneously,incrementally and sequentially. Does Trump or the Ayatollah know they are playing roles or is one or the other oblivious and believe they are acting with free will? If they are practicing free will do the choices on offer come up against hard economic realities or threats thereof that then proscribe what those choices must be? In effect laying out a reality script that is then played out like a theatrical production. If the world operates as Quigley stated with financial capitalism able to control the politics of all individual nations and the world economy as a whole, conducted through central bank policy arrived at in frequent conferences and meetings then what if any ...
After nearly ten years on the job, Lexus has confirmed the end of production for the SC 430, the second-generation model in the SC line.. Standing as Lexus first two-door hard-top coupe convertible, the styling of SC 430 polarised opinions, particularly among fans of the first-generation Toyota Soarer-based Lexus SC.. To its credit, the design SC 430 paved the way for Lexus L-finesse styling language that has dictated styling of the Japanese luxury carmakers current line-up. It was also powered by Toyotas venerable 4.3 litre V8, which drove the LS 430 and a number of overseas Lexus models.. Significantly, the 4.3-litre V8 also paved the way for the IS F performance sedan, with the first hand-built IS F prototypes featuring the engine. Click to read TMRs review of the Lexus IS F. Lexus Australia Chief Executive Tony Cramb said the end of production for the SC 430 marks a transition point for Lexus.. ...
Background Transition points in the care continuum are particularly prone to risk, and the communication of medication information has been identified as a key area for improving the safety of health care
I guess I should clarify that the hamburger button issue only comes up once the top menu has switched to the simplified version, after scrolling down a bit on a page. When I have the full header menu everything works fine; once I scroll down past the transition point the simplified menu comes up, but nothing registers as clickable on it. So, if theres a link in a comment hiding behind the hamburger button, trying to push the hamburger will actually take me to the link behind it. The menu bar is there visually just not functionally ...
Chronic Pain is any pain that lasts longer than the expected healing time and continues despite outward signs of injury. Anywhere 3 to 12 months post injury can be considered the transition point from acute to chronic pain.
When infectious disease pandemics emerge, viruses tend to be the most lethal. Experts are working on ways to find new antiviral drug treatments, as well as to prevent epidemics from emerging in the first place.
Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at the National Institutes of Health (NIH) in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to infection. The changes included a marked decline in antiviral responses that correlated with clearance of virus from white blood cells. The analysis also showed that the preponderance of host responses shifted rapidly from activation of genes involved in cell damage and inflammation toward those linked to promotion of cellular and organ repair. ...
Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at the National Institutes of Health in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to...
Medication reconciliation is the process of creating the most accurate list possible of all medications a patient is taking including drug name, dosage, frequency, and route, and comparing that list against the admission, transfer, and/or discharge orders, with the goal of preventing unintended chnages or omissions during transition points. ...
The annual United Nations Office on Drugs and Crime (UNODC) report on the global drug trade paints a picture of success in Colombia. But its clear the real winners remain the transnational drug gangs, who are evolving fast in response to changing markets.. Many of the trends identified by the 2011 UNODC report have been observed for several years now: Peru is close to edging out Colombia as the worlds top coca producer, and West Africa is becoming an increasingly important transition point for cocaine trafficked to Europe. These are developments that continued, or even accelerated, in 2010, the report finds.. The UNODC supplies plenty of numbers on interdiction, production and consumption rates. But out of the statistics, there are a a few key, general points worth taking away:. 1. Coca and cocaine production is down in Colombia, but increasing in Peru. This is a development identified by the UNODC in last years report, and again appears to be the main headline pulled out of this years ...
or adrenal cause. Documented fevers can suggest malignancy or infection. Tachycardia can be related to adrenal tumors or pain.. On abdominal exam you should begin by inspecting the abdomen - does it appear notably distended? Is it asymmetric?. Percussion should be used alongside palpation to assess for hepatomegaly or splenomegaly, which would warrant U/S investigation.. Investigations. In most cases, the imaging modality of choice is an abdominal ultrasound, which can help to identify the location, vascular supply and characteristics of the mass.. If concerned about constipation abdominal radiographs may be completed in order to rule out obstruction or to look for a transition point in the colon.. ...
chains in the Genus database with same CATH superfamily 4KSK C; 2RPQ A; 3A33 B; 3CMM B; 3NY5 A; 2EMT A; 3SD5 A; 2KJ6 A; 3QQ8 B; 4ICU A; 1YD8 U; 2KWU B; 3RZF A; 4RM8 A; 2HD5 B; 3R3M A; 2FAZ A; 2MA9 B; 2JZ3 B; 3ALB A; 2XEW A; 2DYM A; 2DZK A; 3NOB A; 4LDT D; 2KC1 A; 3M3J A; 2KWV B; 2LD9 A; 2MW5 A; 4W9K A; 2GBM A; 1A5R A; 3TJP A; 1V86 A; 1WE6 A; 1SE9 A; 2G4S A; 3V6E B; 1S3S G; 2PEA A; 3TCA A; 2R2O A; 3HK0 A; 3VH3 B; 4EKU A; 2KC2 A; 3B0A A; 1RAX A; 1NDD A; 2G4D B; 2REX A; 1WGR A; 2FCM A; 3QK0 A; 4NAW B; 4WQO B; 2A5U A; 1OEY A; 3QC8 B; 5D94 A; 2JWZ A; 3QCA A; 3Q3J A; 3PRZ A; 4MEL A; 4HVB A; 1XQQ A; 2JF5 A; 3DDC B; 2D07 B; 4YL8 A; 2K39 A; 4BVU C; 3N32 A; 1TBE A; 1V5O A; 3VFK A; 3L13 A; 3ZNG C; 4DHJ D; 1UBQ A; 2LAS A; 5DPT A; 2KK8 A; 2ZVN A; 4MGZ E; 3QAR A; 4KZ0 A; 1WFY A; 3RZW C; 3OJ3 A; 2KMA A; 2KDF B; 3IVF A; 1EUV B; 4IM0 A; 3RD2 A; 2ZCB A; 5AEK B; 5AZH A; 2OOB B; 3ZDT A; 3DQV A; 2JPH A; 3A9K A; 5D2M B; 2A4Z A; 3QWZ B; 3PTF C; 4FLH A; 1OGW A; 1IYF A; 2O6V B; 2M0X A; 3AI5 A; 3APC A; 1WJN A; 4FUL A; ...
Development Approach Plan: The Development Approach Plan describes the approach to developing technologies or information system(s). The approach to development incorporates methodology, processes, transition points, people and tools to be used. The level of detail in the Development Approach Plan is dependent upon the characteristics of the project (e.g., new development or maintenance), Statement of Work (SOW) requirements, stakeholder needs, etc.. The Development Approach belongs to a tree of plans subordinate to the Project Management Plan (PMP.) If a corporate System Development Management Plan (SDMP) exists, the Development Approach Plan may reference the corresponding section(s) of the SDMP rather than reiterating the content of the SDMP in the Development Approach Plan. Where applicable, references to the SDMP should also be augmented to address any additional information or deviations from the SDMP that are specific to the given project.. Financial Management Plan: The Financial ...
Biological pattern formation often relies on self-organization, integrating biochemical with mechanical patterning processes. Such patterns are particularly important during embryogenesis, as they increase spatial complexity through a sequence of organizing processes that generally build upon previously established pre-patterns. How pre-patterns control self-organization remains unexplored. Here we investigate PAR polarity establishment in the C. elegans zygote, by combining measurements of the spatial distribution of protein numbers and fluxes with a physical theory. We characterize the handover from a pre-pattern to mechanochemical self-organization, and find that guiding cues from the centrosome steer the patterning system comprised of PAR proteins and the actomyosin cortex to a transition point beyond which the patterned state becomes self-organized. This mechanism of controlled pattern formation integrates mechanical and molecular aspects of biological pattern formation with guiding cues. ...
Choice of career is very significant for all 16+ students. A great deal of thought and careful consideration should be given to the very important decisions that have to be made at this stage. The Skills Development Scotland (SDS) Careers Adviser attached to Bucksburn Academy, and in school 2-3 days per week, is Ms Claire Rankine. SDS aim to help pupils understand and develop Career Management Skills to ensure they are successful planners not only in school and as they approach transition points, but throughout their lives. A flexible approach is adopted - use of www.myworldofwork.co.uk as well as face to face support from Ms Rankine through group work, drop in clinics, 1:1 interviews and attendance at reviews/meetings as appropriate. Combined with Pupil Support Staff and appropriate classroom teachers, a valuable careers information, advice and guidance service designed to meet all young peoples needs is provided.. Students should be aware of the constantly changing labour market and the ...
A variety of different methods for the evaluation of antiviral agents in cell culture systems are briefly reviewed. It has been repeatedly noted that many test conditions such as the cell culture system, virus strain, virus challenge dose, virus input multiplicity of infection, and time of harvesting, etc., can substantially affect or even alter the test results, thus making comparative studies and unambiguous evaluations very difficult. Attempts are made to discuss previous test methods together with our recent studies with the aim to simplify test procedures and assay methods. Suggestions are proposed for in vitro evaluation of new antiviral agents. It is hoped that this review will alarm investigators to the problems of assaying new antiviral agents. If the suggestions made in this review can be followed, the screening of the enormous number of promising antiviral compounds may be made more efficiently in the near future.
Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data. UNC ...
A quantum dot structure possesses the same physical dimensions in every direction while a quantum wire exhibits one dimension longer than the others. This means that quantum dots and nanowires made of the same material exhibit different optical and electrical responses at the nanoscale since these properties are exquisitely size- and shape-dependent. Understanding the size- and shape-dependent evolution of nanomaterial properties has therefore been a central focus of nanoscience over the last two decades. However, it has never been definitively established how a quantum dot evolves into a nanowire as its aspect ratio is made progressively larger. Do quantum properties evolve gradually or do they suddenly transition ...
TY - JOUR. T1 - Morphological and mechanical properties of the Achilles tendon in adolescent boys. AU - Mogi, Yasuyoshi. AU - Torii, Suguru. AU - Kawakami, Yasuo. AU - Yanai, Toshimasa. PY - 2013/9/9. Y1 - 2013/9/9. N2 - The present study aimed to investigate how the morphological and mechanical properties of Achilles tendon change in adolescent boys. Twenty-nine adolescent boys and 12 male adults participated. Ultrasonography was used to measure Achilles tendon elongation. The transition point, that is, the intersection point of the Toeδ and Linearδ regions was determined from tendon elongation-tendon force relationship, and the stiffness and Youngs modulus of the Achilles tendon were calculated from linear region. The hysteresis was calculated as the ratio of the area within the tendon elongation-tendon force loop to the area beneath the load portion of the curve. The stiffness, Youngs modulus and stress at transition point were greater in adults (544 ± 231 N/mm, 1.6 ± 0.7 GPa, 23 ± 6 ...
The transition sequence in the Heusler alloy Ni50Mn34In8Ga8 has been determined from measurements of elasticity, heat flow and magnetism to be paramagnetic austenite → paramagnetic martensite → ferromagnetic martensite at ~335 and ~260 K, respectively, during cooling. The overall pattern of elastic stiffening/softening and acoustic loss is typical of a system with bilinear coupling between symmetry breaking strain and the driving order parameter in a temperature interval below the transition point in which ferroelastic twin walls remain mobile under the influence of external stress. Divergence between zero-field-cooling (ZFC) and field-cooling (FC) determinations of DC magnetisation below ~220 K indicates that a frustrated magnetic glass develops in the ferromagnetic martensite. An AC magnetic anomaly which shows Vogel-Fulcher dynamics in the vicinity of ~160 K is evidence of a further glassy freezing process. This coincides with an acoustic loss peak and slight elastic stiffening that is ...
25% Glass Filled Rigid PTFE Tube (PolyTetraFluoroEthylene Pipe) Extruded in 1m or 2m lengthsPTFE Tube is one of the most thermally stable plastic materials; there is no appreciable decomposition below 400°C. The arrangement of the PTFE molecules varies with temperature. There are different transition points, with the most important ones being 19°C corresponding to a modification of some physical properties, and then at 327°C which corresponds to the disappearance of the crystalline structure; the PTFE assumes an amorphous aspect, conserving its own geometric form.The linear thermal expansion coefficient varies with temperature. In addition, because of the orientation caused by the working process, the PTFE pieces are in general anisotropic; the coefficient of expansion varies also in relation to direction. The coefficient of thermal conductivity of the PTFE Tube does not vary with temperature; it is relatively high so that PTFE can be considered to be a good insulation material.The specific heat, as
In this study of three-dimensional (3D) printed composite β-tricalcium phosphate (β-TCP)-/hydroxyapatite/poly(ɛ-caprolactone)-based constructs, the effects of vertical compositional ceramic gradients and architectural porosity gradients on the osteogenic differentiation of rabbit bone marrow-derived mesenchymal stem cells (MSCs) were investigated. Specifically, three different concentrations of β-TCP (0, 10, and 20 wt%) and three different porosities (33% ± 4%, 50% ± 4%, and 65% ± 3%) were examined to elucidate the contributions of chemical and physical gradients on the biochemical behavior of MSCs and the mineralized matrix production within a 3D culture system. By delaminating the constructs at the gradient transition point, the spatial separation of cellular phenotypes could be specifically…. ...
A heat-resistant adhesive is provided for use in an adhesive member for the fabrication of a semiconductor package by bonding a semiconductor chip to a lead frame with the adhesive member and sealing at least the semiconductor chip and a bonded part between the semiconductor chip and the lead frame with a sealant. The adhesive has a coming-out length of not more than 2 mm and a water absorption rate of not more than 3 wt. %. Preferably, the adhesive has a glass transition point of at least 200.degree. C.
Eastman OS300 polyester resin is a high molecular weight polyester resin suitable for sanitary interior container coatings with a glass transition point of approximately 70˚C.
This private blood analysis for Insulin Antibodies is accessible at all thirty one private clinics around the UK Included in each order for Insulin Antibodies are a Doctors Referral, all Phlebotomy fees (your blood taken at a Private Hospital), all laboratory fees and includes our GP comments.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
1GTH: Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with Nadph and 5-Iodouracil. Implications for Mechanism of Inhibition and Electron Transfer
Shop for Beauty, Skin Care, Accessories, Scissors, Hair online from Fishpond.co.nz, New Zealands biggest online store. Millions of products at discount prices - Its shopping made easy.
5-Bromouracil Moreno, Andrew (2016). "Photophysical Characterization of Enhanced 6-Methylisoxanthopterin Fluorescence in Duplex ...
5-Bromouracil Bromodeoxyuridine 5-bromouridine in Linstrom, Peter J.; Mallard, William G. (eds.); NIST Chemistry WebBook, NIST ...
Base analog such as 5-bromouracil may substitute for thymine in replication. Metals such as cadmium, chromium, and nickel can ...
5-Bromouracil 5-Bromouridine 5-Ethynyl-2'-deoxyuridine Trypan blue Lehner, Bernadette; Sandner, Beatrice; Marschallinger, Julia ...
TDG can also remove uracil and 5-bromouracil from mispairings with guanine. TDG knockout mouse models showed no increase in ...
Henderson, J.P. (2003). "Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in ...
"Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking". Nature. 359 ( ...
Nucleoside analogues such as 2-aminopurine and 5-bromouracil can insert in place of A and T respectively. Ionizing radiation ...
One of the most common base analogs is 5-bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. ... When a nucleotide containing 5-bromouracil is incorporated into the DNA, it is most likely to pair with adenine; however, it ...
One common mutagenic base analog is 5-bromouracil, which resembles thymine but can base-pair to guanine in its enol form. Other ...
5-Bromouracil and 3-Bromo-tyrosine have been identified in human white blood cells as products of myeloperoxidase-induced ...
5- bromouracil (5-BU) is a common analog to thymine, however the enol form of 5-BU is still able to bind with adenine. The ...
... bromouracil MeSH D03.383.742.698.875.404 - fluorouracil MeSH D03.383.742.698.875.404.850 - tegafur MeSH D03.383.742.698.875.480 ...
A. Muller, W. Köhnlein, and K. G. Zimmer X-Ray-Induced unpaired Spins in Nucleic Acid Bases and in 5-bromouracil, Journal of ...
... (5-BrU, 5BrUra, or br5Ura) is a brominated derivative of uracil that acts as an antimetabolite or base analog, ...
5-Bromouracil (5-BrU, 5BrUra, or br5Ura) is a brominated derivative of uracil that acts as an antimetabolite or base analog, ...
... bromouracil and bromodeoxyuridine, have been studied. Bromouracil inhibits tentacl ... Bromouracil inhibits tentacle regeneration inH. vulgaris andH. viridis; bromodeoxynridine inhibits tentacle regeneration inH. ... Goyns, M.H., Stanisstreet, M. The effects of bromodeoxyuridine and bromouracil on regeneration inHydra . W. Roux Archiv f. ... The effects of bromodeoxyuridine and bromouracil on regeneration inHydra *M. H. Goyns1. & ...
5-bromouracil explanation free. What is 5-bromouracil? Meaning of 5-bromouracil medical term. What does 5-bromouracil mean? ... Looking for online definition of 5-bromouracil in the Medical Dictionary? ... 5-bromouracil. Also found in: Dictionary, Encyclopedia, Wikipedia. 5-bro·mo·u·ra·cil. (brō-mō-yūră-sil), Synthetic analogue ( ... 5-bromouracil , definition of 5-bromouracil by Medical dictionary https://medical-dictionary.thefreedictionary.com/5- ...
5-Bromouracil ; Point mutations ; Keto-enol tautomerism ; Rare tautomer hypothesis ; Wobble pair ; Base stacking ; Density ... 5-Bromouracil ; Point mutations ; Keto-enol tautomerism ; Rare tautomer hypothesis ; Wobble pair ; Base stacking ; Density ... This thesis describes a computational investigation of the mutagenicity of 5-bromouracil (BrU). In Chapter 1, three models of ...
Pairing properties of bromouracil and repair of bromouracil-containing DNA. Possible utilization of bromodeoxyuridine ... Pairing properties of bromouracil and repair of bromouracil-containing DNA. Possible utilization of bromodeoxyuridine ... Pairing properties of bromouracil and repair of bromouracil-containing DNA. Possible utilization of bromodeoxyuridine ... Pairing properties of bromouracil and repair of bromouracil-containing DNA. Possible utilization of bromodeoxyuridine ...
By contrast, the pyrene-donor and 5-bromouracil-acceptor system indicates that DNA may not act as an efficint medium for the ... Study on Electron Transfer Through RNA/DNA Duplex Using Pyrene and 5-Bromouracil As an Electron Donor and Acceptor Pair. ... We have conducted the research on CT in RNA duplexes consisting of a pendant donor (pyrene) and acceptor (5-bromouracil or ...
symbol: BrUra; 5‐bromouracil; 5‐bromo‐2,4(1H,3H)‐pyrimidine‐dione; a synthetic analogue of thymine with mutagenic activity. It ... Binding of 5-bromouracil-containing S/MAR DNA to the Nuclear Matrix ... Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA ...
... of the thymine in the DNA by 5-bromouracil (BU). In phage PLT-22 transduction, the presence of BU in the donor DNA had no ... The Recombination of Bromouracil-containing Deoxyribonucleic Acid in Salmonella typhimurium Transduction * B. M. WILKINS ... SUMMARY: Salmonella typhimurium tolerated the replacement of about 70% of the thymine in the DNA by 5-bromouracil (BU). In ...
... ZHANG Xiao-Ye1,2, XUE Bin1, CHENG Ze1,2, TAN Zhi-Cheng2, SHI Quan2 ... Uracil,5-Bromouracil,Heat capacity,Physical property measurement system,Thermodynamic function. ". Please open it by linking: ... The heat capacity values of 5-bromouracil are larger than those of uracil as it has a higher molecular weight but a similar ... Key words: Uracil, 5-Bromouracil, Heat capacity, Physical property measurement system, Thermodynamic function ...
Hydrogen Bonding in 5-Bromouracil-Adenine-5-Bromouracil-Adenine (T + AT + A) Tetrads ...
Upon substitution with 5-bromouracil, the S/MAR DNA bound more tightly to the nuclear halos. The multi-functional nuclear ... Upon substitution with 5-bromouracil, the S/MAR DNA bound more tightly to the nuclear halos. The multi-functional nuclear ... Substitution of thymine with 5-bromouracil in DNA is known to change interaction between DNA and proteins, thereby inducing ... Substitution of thymine with 5-bromouracil in DNA is known to change interaction between DNA and proteins, thereby inducing ...
The Reaction of 5-Bromo-uracil with Sodium Diphenylphosphide. Ellermann, Jochen / Demuth, Alfons A. M. ...
5-bromouracil; 5-trifluoromethyluracil; 5-methoxymethyluracil; 5-ethynyluracil; 5-propynyluracil, and the like. ...
Thermodynamics of 5-bromouracil tautomerisation from first-principles molecular dynamics simulations. Research output: Chapter ... Thermodynamics of 5-bromouracil tautomerisation from first-principles molecular dynamics simulations (dataset). Holroyd, L. F ... University , Research portal , Research publications , Thermodynamics of 5-bromouracil tautomerisation from first-p... , ...
ALDRICH 5-Bromouracil, 98% MilliporeSigma. Synonym(s): 5-Bromo-2,4-dihydroxypyrimidine Formula: C4H3BrN2O2 Formula Weight: ...
The crystal structure of the intermolecular complex 9-ethyladenine:l-methyl-5-bromouracil. ...
Pyrimidine (de); pyrimidines (en); pirimidinoj (eo); pirymidyna (pl); pyrimidin (nn) any heterocyclic compound having a six-membered aromatic ring with two nitrogen heteroatoms at 1 and 3 positions (en); każdy związek heterocykliczny zawierający sześcioczłonowy, aromatyczny pierścień z dwoma heteroatomami azotu w pozycjach 1 i 3 (pl) pyrimidine (en); pyrimidina (nn); pirymidyny (pl ...
Induction of lethal damage in E. coli by Cerenkov emission associated with high-energy X-rays: the effect of bromouracil ... the effect of bromouracil substitution.}, author={Terry L Morgan and J Leslie Redpath and John F. Ward}, journal={International ...
bromouracil. mimic nucleotides and cause transition mutations. What are intercalating agents. Proflavin. Wedge themselves into ...
bromouracil. busulfan. burn unit. BU. 1. Bodansky Unit.. 2. Bromouracil.. 3. Busulfan. ...
Setlow, R.B., and Regan, J.D. (1981). Measurement of repair synthesis by photolysis of bromouracil. InDNA Repair, Vol. 1, part ...
5-Bromo-2,4(1H,3H)-pyrimidinedione; 5-BrU; 5-BU; Bromouracil; 2,4(1H,3H)-Pyrimidinedione, 5-bromo-; Uracil, 5-bromo-; [ ... 5-Bromo-2,4(1H,3H)-pyrimidinedione; 5-BrU; 5-BU; Bromouracil; 2,4(1H,3H)-Pyrimidinedione, 5-bromo-; Uracil, 5-bromo-; [ ...
what does 5-bromouracil do in dna in keto form still pairs to adenine. however presence of bromine modifies electron ...
5-Bromouracil Moreno, Andrew (2016). "Photophysical Characterization of Enhanced 6-Methylisoxanthopterin Fluorescence in Duplex ...
1993) Ionization of bromouracil and fluorouracil stimulates base mispairing frequencies with guanine. J Biol Chem 268:15935- ...
B is 5-Bromouracil or other 5-Halouracil or Uracil; sequences are shown with their 5 end to the left): DGG, BDDG, DDGG; DGGD; ...
1978 Strand breaks and alkali-labile bonds induced by ultraviolet light in DNA with 5-bromouracil in vivo. Biophys. J. 24: 657- ... 1966 Selectivity for thymine over 5-bromouracil by a thymine-requiring bacterium. Biochim. Biophys. Acta 123: 356-363. ... The toxicity of 5-bromouracil is thought to be due in part to the lower incorporation efficiency of this base analogue compared ... Irradiated or mock-irradiated cultures were incubated in medium containing 5-bromouracil in place of thymine for 1 hr such that ...
... : broken, brokenhearted, brokenheartedly, brokenheartedness, brokenly, brokenness, broker, brokerage, brokered, brokeries, brokering, brokers, brokery, brokes, broking, brolga, brollies, brolly, bromal, bromate...
a) Bromouracil √. b) Acridine orange. c) Both the above. *DNA sequence where mutations occur frequently are called ...
8 -5-aminouracil; 5-bromocytosine; 5-bromouracil; 5-chlorocytosine; 5-chlorouracil; 5-fluorocytosine; 5-fluorouracil; 5- ... 5-bromouracil, 5-chlorocytosine, 5-chlorouracil, 5-fluorocytosine, 5-fluorouracil, 5-iodouracil, 5-hydroxycytosine, 5- ...
  • 5-Bromouracil (5-BrU, 5BrUra, or br5Ura) is a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. (wikipedia.org)
  • Salmonella typhimurium tolerated the replacement of about 70% of the thymine in the DNA by 5-bromouracil (BU). (microbiologyresearch.org)
  • Substitution of thymine with 5-bromouracil in DNA is known to change interaction between DNA and proteins, thereby inducing various biological phenomena. (oup.com)
  • The chemical 5-bromouracil, for example, can replace thymine in the synthesis of DNA, creating a nonfunctional mutation at specific points. (sunjournal.com)
  • 5-bromouracil (replacing thymine) or 2-aminopurine replacing adenine. (academic.ru)
  • Here we study the decomposition of the DNA/RNA nucleobases thymine (T) and uracil (U) and the well-known radiosensitizer 5-bromouracil (BrU) in close vicinity to AuNPs, which are irradiated with a nanosecond pulsed laser (532 nm) matching the surface plasmon resonance of the AuNPs. (uni-potsdam.de)
  • During replicating the DNA, the thymine is replaced by the bromouracil so that the base-pairing adenine-bromouracil is now present. (observertree.org)
  • TDG can also remove uracil and 5-bromouracil from mispairings with guanine. (abnova.com)
  • This can lead to a pairing of the bromouracil with guanine instead of the complementary adenine due to a hydrogen atom's rearrangement. (observertree.org)
  • The heat capacities of uracil and 5-bromouracil were measured using a quantum design physical property measurement system (PPMS) in the temperature range of 1.9-300 K. The experimental results indicate that the heat capacities of the two compounds increase with increasing temperature, and no thermal anomalies are observed across the whole temperature range studied. (pku.edu.cn)
  • The heat capacity values of 5-bromouracil are larger than those of uracil as it has a higher molecular weight but a similar molecular structure. (pku.edu.cn)
  • The standardmolecular entropies at 298.15 K were determined to be (132.48±1.32) and (165.39±1.65) J·K -1 ·mol -1 for uracil and 5-bromouracil, respectively. (pku.edu.cn)
  • Low Temperature Heat Capacities of Uracil and 5-Bromouracil[J].Acta Phys. (pku.edu.cn)
  • Upon substitution with 5-bromouracil, the S/MAR DNA bound more tightly to the nuclear halos. (oup.com)
  • Induction of lethal damage in E. coli by Cerenkov emission associated with high-energy X-rays: the effect of bromouracil substitution. (semanticscholar.org)
  • The effects on tentacle regeneration in Hydra of two DNA-antimetabolites, bromouracil and bromodeoxyuridine, have been studied. (springer.com)
  • The base analogue 5 BromoUracil is used in the chemotherapy of microbial infection. (hubpages.com)
  • Base modifications that stabilize base pairs (5-bromouracil, 5-methylcytosine, 5-propynyluracil, and others) have also been proposed [ 7 , 10 ]. (hindawi.com)
  • En mathématiques, une base d une topologie est un ensemble d ouverts tel que tout ouvert de la topologie soit l union d éléments de cet ensemble. (academic.ru)
  • Measurement of repair synthesis by photolysis of bromouracil. (springer.com)
  • Pairing properties of bromouracil and repair of bromouracil-containing DNA. (biochemj.org)
  • The multi-functional nuclear matrix protein YY1 was also found to bind more strongly to 5-bromouracil-substituted DNA containing its recognition motif. (oup.com)