Bromosuccinimide
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2-Hydroxy-5-nitrobenzyl Bromide
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An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
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A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
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Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
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Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
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Localization and environment of tryptophans in soluble and membrane-bound states of a pore-forming toxin from Staphylococcus aureus. (1/116)
The location and environment of tryptophans in the soluble and membrane-bound forms of Staphylococcus aureus alpha-toxin were monitored using intrinsic tryptophan fluorescence. Fluorescence quenching of the toxin monomer in solution indicated varying degrees of tryptophan burial within the protein interior. N-Bromosuccinimide readily abolished 80% of the fluorescence in solution. The residual fluorescence of the modified toxin showed a blue-shifted emission maximum, a longer fluorescence lifetime as compared to the unmodified and membrane-bound alpha-toxin, and a 5- to 6-nm red edge excitation shift, all indicating a restricted tryptophan environment and deeply buried tryptophans. In the membrane-bound form, the fluorescence of alpha-toxin was quenched by iodide, indicating a conformational change leading to exposure of some tryptophans. A shorter average lifetime of tryptophans in the membrane-bound alpha-toxin as compared to the native toxin supported the conclusions based on iodide quenching of the membrane-bound toxin. Fluorescence quenching of membrane-bound alpha-toxin using brominated and spin-labeled fatty acids showed no quenching of fluorescence using brominated lipids. However, significant quenching was observed using 5- and 12-doxyl stearic acids. An average depth calculation using the parallax method indicated that the doxyl-quenchable tryptophans are located at an average depth of 10 A from the center of the bilayer close to the membrane interface. This was found to be in striking agreement with the recently described structure of the membrane-bound form of alpha-toxin. (+info)Characterization of exo-(1,4)-alpha glucan lyase from red alga Gracilaria chorda. Activation, inactivation and the kinetic properties of the enzyme. (2/116)
Exo-(1,4)-alpha glucan lyase (GLase) was purified from a red alga Gracilaria chorda. The enzyme was activated 1.3-fold in the presence of Ca(2+) and Cl(-) ions. The ions also stabilized the enzyme increasing the temperature of its maximum activity from 45 degrees C to 50 degrees C. GLase was inactivated by chemical modification with carbodiimide and a carboxyl group of the enzyme was shown essential to the lyase activity. A tryptophanyl residue(s) was also shown to be important for the activity and was probably involved in substrate binding. K(m) values of the enzyme were 2.3 mM for maltose, 0.4 mM for maltotriose and 0.1 mM for maltooligosaccharides of degree of polymerization (dp) 4-7, and the k(0) values for the oligosaccharides were similar (42-53 s(-1)). The analysis of these kinetic parameters showed that the enzyme has four subsites to accommodate oligosaccharides. The subsite map of GLase was unique, since subsite 1 and subsite 2 have large positive and small negative affinities, respectively. The subsite map of this type has not been found in other enzymes with exo-action on alpha-1,4-glucan. The K(m) and k(0) values for the polysaccharides were lower (0.03 mM) and higher (60-100 s(-1)), respectively, suggesting the presence of another affinity site specific to the polysaccharides. (+info)Energy transfer between terbium (III) and cobalt (II) in thermolysin: a new class of metal--metal distance probes. (3/116)
The visible fluorescence of terbium(III) when bound to a calcium binding site of thermolysin is greatly enhanced with an excitation maximum at 280 nm but substitution of cobalt(II) for zinc at the active site decreases the intensity by 89.5%. Treatment with N-bromosuccinimide quenches enzyme tryptophan and Tb(III) fluorescence to a similar extent and suggests the operation of tryptophan vector Tb(III) vector Co(II) energy relay system in the enzyme. Dipoledipole radiationless energy transfer between the Tb(III) donor and the Co(II) acceptor can account for this quenching. The inherent characteristics of the metal pair limits the value of the orientation factor, K2, of the Forster equation, thereby reducing uncertainties in distance measurements by energy transfer compared with other systems. A quantum yield of 0.51 yields a value of R0, the distance for 50% energy transfer, of 19.6 A, and a distance, R, between Tb(III) and Co(II) of 13.7 A, a value identical to that measured for the distance between the active site zinc atom and calcium atom number 1 by x-ray analysis in native thermolysin crystals. The limits of confidence of this measurement are discussed. Energy transfer between two different metal atom sites of a protein provides a new class of probes to measure intramolecular distances of biological macromolecules in solution. (+info)Purification and characterization of beta-1,3-xylanase from a marine bacterium, Vibrio sp. XY-214. (4/116)
beta-1,3-Xylanase was purified to gel electrophoretic homogeneity and 83-fold from a cell-free culture fluid of Vibrio sp. XY-214 by ammonium sulfate precipitation and successive chromatographies. The enzyme had a pl of 3.6 and a molecular mass of 52 kDa. The enzyme had the highest level of activity at pH 7.0 and 37 degrees C. The enzyme activity was completely inhibited by Cu2+, Hg2+, and N-bromosuccinimide. The enzyme hydrolyzed beta-1,3-xylan to produce mainly xylotriose and xylobiose but did not act on xylobiose, p-nitrophenyl-beta-D-xyloside, beta-1,4-xylan, beta-1,3-glucan, or carboxymethyl cellulose. (+info)Structure-function studies of tryptophan mutants of equinatoxin II, a sea anemone pore-forming protein. (5/116)
Equinatoxin II (EqtII) is a eukaryotic cytolytic toxin that avidly creates pores in natural and model lipid membranes. It contains five tryptophan residues in three different regions of the molecule. In order to study its interaction with the lipid membranes, three tryptophan mutants, EqtII Trp(45), EqtII Trp(116/117) and EqtII Trp(149), were prepared in an Escherichia coli expression system [here, the tryptophan mutants are classified according to the position of the remaining tryptophan residue(s) in each mutated protein]. They all possess a single intrinsic fluorescent centre. All mutants were less haemolytically active than the wild-type, although the mechanism of erythrocyte damage was the same. EqtII Trp(116/117) resembles the wild-type in terms of its secondary structure content, as determined from Fourier-transform infrared (FTIR) spectra and its fluorescent properties. Tryptophans at these two positions are buried within the hydrophobic interior of the protein, and are transferred to the lipid phase during the interaction with the lipid membrane. The secondary structure of the other two mutants, EqtII Trp(45) and EqtII Trp(149), was altered to a certain extent. EqtII Trp(149) was the most dissimilar from the wild-type, displaying a higher content of random-coil structure. It also retained the lowest number of nitrogen-bound protons after exchange with (2)H(2)O, which might indicate a reduced compactness of the molecule. Tryptophans in EqtII Trp(45) and EqtII Trp(149) were more exposed to water, and also remained as such in the membrane-bound form. (+info)Location of tryptophan residues in free and membrane bound Escherichia coli alpha-hemolysin and their role on the lytic membrane properties. (6/116)
alpha-hemolysin (HlyA) is an extracellular protein toxin secreted by Escherichia coli that acts at the level of plasma cell membranes of target eukaryotic cells. Previous studies showed that toxin binding to the bilayers occurs in at least two ways, a reversible adsorption and an irreversible insertion. Studies of HlyA insertion into bilayers formed from phosphatidylcholine show that insertion is accompanied by an increase in the protein intrinsic fluorescence. In order to better define structural parameters of the membrane-bound form, the location of tryptophan residues was studied by means of quenchers of their intrinsic fluorescence located at 7, 12 and 16 positions of the acyl chain of phosphatidylcholine. The quenching was progressively weaker suggesting an interfacial location of the Trp. In parallel, HlyA was subjected to oxidation with N-bromosuccinimide to study the role of Trp residues exposed to aqueous media in its structure-function relationship. In the folded toxin molecule, a single residue was susceptible to oxidation with NBS, whereas incubation with LUV of the toxin prior modification prevents its oxidation, suggesting that Trp residue(s) are directly involved in toxin binding and insertion. Finally, the modification of residues exposed to solvent resulted in a complete impairment of the lytic activity. It was concluded that the modification-sensitive Trp residues are essential for the structure and function of native HlyA. These results are consistent with the model proposed by Soloaga et al. (Mol. Microbiol. 31 (1999) 1013-1024) according to which HlyA is bound to a single monolayer through a number of amphipathic instead of inserted transmembrane helices. (+info)Involvement of arginine and tryptophan residues in catalytic activity of glutaryl 7-aminocephalosporanic acid acylase from Pseudomonas sp. strain GK16. (7/116)
The glutaryl 7-aminocephalosporanic acid (GL-7-ACA) acylase from Pseudomonas sp. strain GK16 is an (alphabeta)2 heterotetramer of two non-identical subunits that are cleaved autoproteolytically from an enzymatically inactive precursor polypeptide. The newly formed N-terminal serine of the beta subunit plays an essential role as a nucleophile in enzyme activity. Chemical modification studies on the recombinant enzyme purified from Escherichia coli revealed the involvement of a single arginine and tryptophan residue, per alphabeta heterodimer of the enzyme, in the catalytic activity of the enzyme. Glutaric acid, 7-aminocephalosporanic acid (7-ACA) (competitive inhibitors) and GL-7-ACA (substrate) could not protect the enzyme against phenylglyoxal-mediated inactivation, whereas except for glutaric acid protection was observed in case of N-bromosuccinimide-mediated inactivation of the enzyme. Kinetic parameters of partially inactivated enzyme samples suggested that while arginine is involved in catalysis, tryptophan is involved in substrate binding. (+info)Tryptophan environment in adenosine deaminase. I. Enzyme modification with N-bromosuccinimide in the presence of adenosine and EHNA analogues. (8/116)
Adenosine deaminase from bovine cerebral hemisphere (white and gray matter) and spleen was treated with N-bromosuccinimide, a reagent known to oxidize selectively tryptophan residues in proteins. Spectrally observable tryptophan modification was accompanied by enzyme inactivation. Tsow graphics revealed that two Trps are essential for the activity of enzyme from both tissues. Enzyme inhibitors and substrate analogues, derivatives of erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and adenosine, were able to protect Trp against modification, and this effect correlated in general with the enzyme activity protection. In the presence of adenosine deaza analogues (the noninhibitor tubercidin among them) only two Trps were modified in the fully inactivated enzyme. In the presence of EHNA and its deaza analogues, full inactivation of the enzyme was accompanied by the modification of four Trps. The obtained data confirm the previous hypothesis about the presence on the enzyme of different binding sites for adenosine and EHNA derivatives that are responsible for the different effects on the enzyme conformation elicited by the corresponding derivatives. Moreover, these data allow us to suggest that Trp residues, still unidentified by X-ray analysis, are essential for the functioning of the enzyme. (+info)
N-Bromosuccinimide | 128-08-5
CAS No.128-08-5,N-Bromosuccinimide Suppliers
L K Ramachandran
Gentaur Molecular :Nacala \ N‐Bromosuccinimide \ 05823-22
Aripiprazole | Methylene Blue | N-bromosuccinimide | Spectrophotometry
Kinetics and Mechanism of Micellar Catalyzed Oxidation of Dextrose by N-Bromosuccinimide in H2SO4 Medium
Reaktionen von ( E)-Cycloocten mit N-Bromsuccinimid in Gegenwart von Wasser oder Methanol | SpringerLink
Formation of bromohydrins from alkenes using water and NBS
Vicinal bromofluoroalkanes: their regioselective formation and their conversion to fluoro olefins
Epigenetic changes behind chronic kidney disease
Chiral N,N′-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine...
Global N-Bromosuccinimide Market Research Report 2017 - RnR Market Research
N-Bromosuccinimide and Lithium Bromide: An Efficient Combination for the Dibromination of Carbon-Carbon Unsaturated Bonds
The subunit structure of jack-bean urease | Biochemical Journal
Azatriptycene.
TWO SELECTIVE SPECTROPHOTOMETRY METHODS FOR THE DETERMINATION OF THIORIDAZINE HYDROCHLORIDE IN TABLETS AND IN BIOLOGICAL FLUIDS
Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation | Biochemical Journal
Tryptophan residue is essential for immunoreactivity of a diagnostically relevant peptide epitope of A. fumigatus -...
A guide to avoid method bias of chromium(III, VI) chemiluminescence determination by luminol-hydrogen peroxide reaction....
Compounds and possessed relatively low
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Algorithms | Free Full-Text | Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein...
Process optimization for production and purification of a thermostable, organic solvent tolerant lipase from Acinetobacter sp....
Pseudocholinesterase Deficiency - Treatment, Symptoms, Causes, Prognosis
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Neuromuscular · Part One
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Serum Atypical Pseudocholinesterase and Genetic Factors in Leprosy | The BMJ
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Kinetics of the methylene blue oxidation by cerium(iv) in sulphuric acid solutions<...
PQR | N-(4-{hydroxy[(4-nitrobenzyl)oxy]phosphoryl}butanoyl)glycine
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Erythrosine
"N-Bromosuccinimide". ACS Omega. 3 (10): 12868-12877. doi:10.1021/acsomega.8b02320. PMC 6644467. PMID 31458011. Cantor S (April ...
Wohl-Ziegler bromination
Once all N-bromosuccinimide (which is denser than the solvent) has been converted to succinimide (which floats on top) the ... In a typical setup, a stoichiometric amount of N-bromosuccinimide solution and a small quantity of initiator are added to a ... Best yields are achieved with N-bromosuccinimide in carbon tetrachloride solvent. Several reviews have been published. ... 1948-10-01). "Brominations with N-Bromosuccinimide and Related Compounds. The Wohl-Ziegler Reaction". Chemical Reviews. 43 (2 ...
Carbanion
N-bromosuccinimide and diiodine), and proton donors. A carbanion is one of several reactive intermediates in organic chemistry ...
N-Chlorosuccinimide
N-bromosuccinimide (NBS), the bromine analog of N-chlorosuccinimide. Other N-chloro compounds that are commercially available ...
Fostedil
Bromination of this compound with N-bromosuccinimide produces bromomethyl intermediate. The synthesis of fostedil concludes ...
Cyanamide
... adds itself in the presence of N-bromosuccinimide to olefinic double bonds. The addition product is converted by ...
Photochlorination
N-bromosuccinimide is also suitable as a brominating agent. The quantum yield of photobromination is usually much lower than ...
Succinimide
Succinic anhydride N-Hydroxysuccinimide N-Bromosuccinimide International Union of Pure and Applied Chemistry (2014). ...
1,2-Dibromoethylene
Alternately, halogenation of this kind could also be achieved through the use of two equivalents of N-bromosuccinimide and ... Shao, L.-X.; Shi, M. (2006). "N-Bromosuccinimide and Lithium Bromide: An Efficient Combination for the Dibromination of Carbon- ... lithium bromide (LiBr). N-Bromosuccinimide provides Br+ as an electrophile, which is followed by Br− from LiBr. "Chapter 9: ...
Canthaxanthin
Petracek, F. J.; Zechmeister, L. (1956). "Reaction of beta-carotene with N-bromosuccinimide: the formation and conversions of ...
Bromochlorobenzene
... silane using N-bromosuccinimide From 4-chlorophenol using triphenylphosphine dibromide or phenylphosphorus tetrachloride ... "Carbon-silicon bond cleavage of organotrialkoxysilanes and organosilatranes with m-chloroperbenzoic acid and N-bromosuccinimide ...
SPANphos
The resultant spirocycle is halogenated with N-bromosuccinimide followed by lithium-bromide exchange using n-BuLi. Treatment of ...
Benzo(c)fluorene
... using the reagent N-bromosuccinimide. This substance is dehydrobrominated to 2H-inden-1-one (3) using the reagent triethylamine ...
Indole
Simple oxidants such as N-bromosuccinimide will selectively oxidize indole 1 to oxindole (4 and 5). Only the C2-C3 pi bond of ...
Hofmann rearrangement
Sodium hypochlorite, lead tetraacetate, N-bromosuccinimide, and (bis(trifluoroacetoxy)iodo)benzene can effect a Hofmann ...
Toluene
For example, N-bromosuccinimide (NBS) heated with toluene in the presence of AIBN leads to benzyl bromide. The same conversion ...
2-Furonitrile
... for the instance oxidative dehydration of furfural with ammonia salts using hypervalent iodine reagents or n-bromosuccinimide. ...
Vinorelbine
Anhydrovinblastine is then reacted sequentially with N-bromosuccinimide and trifluoroacetic acid followed by silver ...
Chemistry of ascorbic acid
Another alternative uses N-bromosuccinimide (NBS) as the oxidizing agent, in the presence of potassium iodide and starch. The ...
Bis(cyclopentadienyl)titanium(III) chloride
Anhydrovinblastine is then reacted sequentially with N-bromosuccinimide and trifluoroacetic acid followed by silver ...
In-Methylcyclophane
Next the methyl substituents are functionalized with bromine groups by the photochemical reaction with N-bromosuccinimide or ...
N-Iodosuccinimide
NIS is the iodine analog of N-chlorosuccinimide (NCS) and N-bromosuccinimide (NBS) which are used for similar applications. "N- ...
L-Photo-leucine
Then, N-bromosuccinimide, CCl4 and 48% HBr are added and the mixture is stirred at 55 °C for 4 hours. The solvent and free ...
Alkenylaluminium compounds
8) Treatment of alkenylaluminates with halogen electrophiles such as N-bromosuccinimide (NBS) and iodine leads to the formation ... of N-bromosuccinimide while keeping the temperature below -15°. The reaction mixture was gradually warmed to room temperature ...
Bromine
... such as N-bromosuccinimide. The principal reactions for organobromides include dehydrobromination, Grignard reactions, ...
Stilbene photocyclization
After benzylic bromization with N-bromosuccinimide, transformation to the phosphonium salt, and a Wittig reaction with ...
Ramberg-Bäcklund reaction
... be synthesized through the treatment of sulfides with halogen electrophiles such as N-chlorosuccinimide or N-bromosuccinimide.[ ...
Fluoxymesterone
N-bromosuccinimide (NBS), is determined by the formation of a bromonium intermediate; the electrophilic bromonium cation ...
Formazan
Among the various oxidants used are mercuric oxide, nitric acid, isoamyl nitrite, N-bromo succinimide, potassium permanganate, ...
Imide
Examples that are useful in organic synthesis are N-chlorosuccinimide and N-bromosuccinimide, which respectively serve as ...
N-Bromosuccinimide - Wikipedia
N-Bromosuccinimide or NBS is a chemical reagent used in radical substitution, electrophilic addition, and electrophilic ... Dauben, H. J., Jr; McCoy, L. L. (1959). "N-Bromosuccinimide. I. Allylic Bromination, a General Survey of Reaction Variables". J ... Mitchell, R. H.; Lai, Y. H.; Williams, R. V. (1979). "N-Bromosuccinimide-dimethylformamide: a mild, selective nuclear ... Usage of N-bromosuccinimide in organic syntheses Reactions with NBS. ...
N-Bromosuccinimide (NBS)
... is a brominating and oxidizing agent that is used as source for bromine in ... A N-bromosuccinimide-mediated direct synthesis of 2,5-diarylox azoles starting from N-H ketoaziridines proceeds via in situ ... Aryl and heteroaryl boronic acids react with N-iodosuccinimide and N-bromosuccinimide to give the corresponding iodo- and bromo ... A novel electrophilic one-pot reaction of an olefin, a cyanimide, an amine, and N-bromosuccinimide enables the synthesis of a ...
Kinetics and Mechanism of Micellar Catalyzed Oxidation of Dextrose by N-Bromosuccinimide in H2SO4 Medium
... Minu Singh ... for the oxidation of dextrose by N-bromosuccinimide in the absence and presence of SDS and TX-100 at 40°C. ... Kinetics and mechanism of micellar catalyzed N-bromosuccinimide oxidation of dextrose in H2SO4 medium was investigated under ... The determined stoichiometric ratio was 1 : 1 (dextrose : N-bromosuccinimide). The variation of Hg(OAC)2 and succinimide ( ...
Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical...
CAS No.128-08-5,N-Bromosuccinimide Suppliers
where to buy 128-08-5(N-Bromosuccinimide).Also offer free database of 128-08-5(N-Bromosuccinimide) including MSDS sheet( ... N-Bromosuccinimide Basic information Product Name: N-Bromosuccinimide Synonyms: 2,5-PYRROLIDINEDIONE, 1-BROMO-;1-BROMO-2,5- ... Good quantity N-Bromosuccinimide Basic information Product Name: N-Bromosuccinimide Synonyms: 2,5-PYRROLIDINEDIONE, 1-BROMO-;1- ... Synonyms:?2,5-PYRROLIDINEDIONE,?1-BROMO-;1-BROMO-2,5-PYRROLIDINEDIONE;AKOS?BBS-00004413;bromosuccinimide;BROMOSUCCINIMIDE-N; ...
N-Bromosuccinimide Initiated One-Pot Synthesis of Imidazoline
N-Bromosuccinimide Promoted One-Pot Synthesis of Guanidine: Scope and Mechanism. L. Zhou, J. Chen, J. Zhou, Y.-Y. Yeung, Org. ... N-Bromosuccinimide Initiated One-Pot Synthesis of Imidazoline. Ling Zhou, Jing Zhou, Chong Kiat Tan, Jie Chen and Ying-Yeung ... A novel cationic Br initiated one-pot synthesis using olefin, nitrile, amine, and N-bromosuccinimide gives imidazolines in good ...
Aripiprazole | Methylene Blue | N-bromosuccinimide | Spectrophotometry
N-bromosuccinimide (0.0067 mol/l) and methylene blue (0.031 mol/l) were prepared by dissolving 120 mg of N-bromosuccinimide and ... The proposed method is based on the oxidation of drug with N-bromosuccinimide and unreacted N-bromosuccinimide bleaches the ... The proposed method is based on the oxidation of drug with N-bromosuccinimide. Bromine atom of N-bromosuccinimide reacts with ... N-bromosuccinimide (Merck, Mumbai, India) and methylene blue (S.D. Fine Chem, Mumbai, India) were used for the experiment. ...
Molecular Expressions: Science, Optics & You - Olympus MIC-D: Chemical Crystal Movie Gallery - Bromo-Succinimide Movie #1
N-bromosuccinimide serves as an oxidizing agent in the synthesis of drugs and hormones. ... Bromo-Succinimide Movie #1. Used by the pharmaceutical and chemical industries as an intermediary, N-bromosuccinimide serves as ... N-bromosuccinimide (NBS) is characterized by a molecular weight of 177.99, a chemical composition of 4 carbon, 4 hydrogen, 1 ... Alternatively, bromosuccinimide is known to biochemists as 1-bromo-2,5-pyrolidinedione or succinibromide. For the laboratory ...
N-Bromosuccinimide | 128-08-5
You can also browse global suppliers,vendor,prices,Price,manufacturers of N-Bromosuccinimide(128-08-5). At last,N- ... Bromosuccinimide(128-08-5) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need. ... Visit ChemicalBook To find more N-Bromosuccinimide(128-08-5) information like chemical properties,Structure,melting point, ... N-Bromosuccinimide. CAS No.. 128-08-5. Chemical Name:. N-Bromosuccinimide. Synonyms. NBS;NSC 16;NIBRIN;SUCCINBROMIDE; ...
Chiral N,N′-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine...
The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by ... Chiral N,N′-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine ... Chiral N,N′-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine ... The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by ...
N-Bromosuccinimide As An Analytical Reagent For The Spectrophotometric Determination Of Benzimidazole Anthelmintics | Abstract
N-Bromosuccinimide
Literature References: Prepn: K. Ziegler et al., Ann. 551, 109 (1942). In bromination of olefins: eidem, ibid. 80. The method has been extended to other classes of compds by the use of catalysts: H. Schmid, P. Karrer, Helv. Chim. Acta 29, 573 (1946); H. Schmid, ibid. 1144. In oxidation of aldehydes: Y. F. Cheung, Tetrahedron Lett. 1979, 3809. Review of uses: C. Djerassi, Chem. Rev. 43, 271-317 (1948); R. Filler, ibid. 63, 21-43 (1963); J. S. Pizey, Synthetic Reagents vol. 2 (John Wiley, New York, 1974) pp 1-63. ...
Global N-Bromosuccinimide Market Research Report 2017 - RnR Market Research
Global N-Bromosuccinimide Market Research Report 2017 is a market research report available at US $2900 for a Single User PDF ... 1 N-Bromosuccinimide Market Overview. 1.1 Product Overview and Scope of N-Bromosuccinimide. 1.2 N-Bromosuccinimide Segment by ... Global N-Bromosuccinimide Sales Market Report 2017. United States N-Bromosuccinimide Market Report 2017. Global and Chinese N- ... 5.2 Global N-Bromosuccinimide Revenue and Market Share by Type (2012-2017). 5.3 Global N-Bromosuccinimide Price by Type (2012- ...
N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An asymmetric and highly stereoselective...
A novel N-bromosuccinimide induced aminocyclization-aziridine ring expansion cascade is reported. Substituted azepanes were ... N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An asymmetric and highly stereoselective ... Zhou, J., Yeung, Y.-Y. (2014-04-18). N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An ...
Gentaur Molecular :Nacala \ N‐Bromosuccinimide \ 05823-22
Bromosuccinimide \ 05823-22 for more molecular products just contact us ... We have also other products like : N‐Bromosuccinimide. Related products : N‐Bromosuccinimide ... 29094599] N-Bromosuccinimide (NBS)-Catalyzed C-H Bond Functionalization: An Annulation of Alkynes with Electron Withdrawing ... 28911632] Determination of urea in milk based on N-bromosuccinimide-dichlorofluorescein postchemiluminescence method.. [ ...
CIRCULAR DICHROISM STUDIES ON THE N-BROMOSUCCINIMIDE OXIDATION OF RIBONUCLEASE FROM ASPERGILLUS SAITOI.
... Author. OHGI K; IRIE M ... N-BROMOSUCCINIMIDE GROUPE FONCTIONNEL ENZYMOLOGIE BIOCHIMIE Keyword (en). ENZYMES HYDROLASE OXIDATION TRYPTOPHAN ULTRAVIOLET ... 20N-BROMOSUCCINIMIDE%20OXIDATION%20OF%20RIBONUCLEASE%20FROM%20ASPERGILLUS%20SAITOI.&rft.date=1977&rft.aulast=OHGI&rft.aufirst=K ... "CIRCULAR DICHROISM STUDIES ON THE N-BROMOSUCCINIMIDE OXIDATION OF RIBONUCLEASE FROM ASPERGILLUS SAITOI.;s:9:\u0000*\ ...
Patent US8268887 - Drug conjugates and methods of use thereof - Google Patenten
Spectrophotometric determination of pantoprazole sodium in pharmaceuticals using n-bromosuccinimide, methyl orange and indigo...
Spectrophotometric determination of pantoprazole sodium in pharmaceuticals using n-bromosuccinimide, methyl orange and indigo ... in bulk drug and in formulations using N-bromosuccinimide (NBS) and two dyes, methyl orange and indigo carmine, as reagents. ... Spectrophotometric determination of pantoprazole sodium in pharmaceuticals using n-bromosuccinimide, methyl orange and indigo ...
Erythrosine - Wikipedia
Reaktionen von ( E)-Cycloocten mit N-Bromsuccinimid in Gegenwart von Wasser oder Methanol | SpringerLink
... cyclooctene with N-bromosuccinimide in the presence of water or methanol are described. Major products of the ... The reactions of (E)-cyclooctene withN-bromosuccinimide in the presence of water or methanol are described. Major products of ... Reactions of (E)-cyclooctene with N-bromosuccinimide in the presence of water, and methanol, resp. Transanular reactions of ...
Acta Pharmaceutica
Utility of N-bromosuccinimide as an environmental-friendly reagent for sensitive determination of olanzapine in pharmaceuticals...
The methods use N-bromosuccinimide [NBS] and two-dyes, namely quinoline yellow and metanil yellow, as reagents. In titrimetry, ... Utility of N-bromosuccinimide as an environmental-friendly reagent for sensitive determination of olanzapine in pharmaceuticals ... Utility of N-bromosuccinimide as an environmental-friendly reagent for sensitive determina ...
Patent US6593321 - 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity - Google Patents
Journal of Biosciences | Indian Academy of Sciences
... of cardiotoxin II in the biological activity of the toxin was evaluated using N-bromosuccinimide. N-bromosuccinimide effected ... Effect of N-bromosuccinimide-modification of tyrosine side chains of cardiotoxin II of the Indian cobra on biological activity ... Oxidation of cardiotoxin II with 3.75 equivalents of N-bromosuccinimide tyrosine residue led to complete loss of lethal ... N-bromosuccinimide, to achieve oxidation. In Tris-HCl buffer oxidation of tyrosine did not take place effectively. N-iodo- ...
Direct oxidation of polymeric substrates by multifunctional manganese peroxidase isoenzyme from Pleurotus ostreatus without...
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6. N-Bromosuccinimide was purchased from Aldrich Chemical Company, Inc. , and used without purification; the purity of the ... N-bromosuccinimide (11.8 g, 66 mmol) (Note 6) at 0°C. After 15 min, the bath is removed, and stirring is continued at room ... The combination of N-bromosuccinimide, which is a source of electropositive bromine, and Et3N·3HF is a very convenient reagent ... N-Bromosuccinimide: Succinimide, N-bromo- (8); 2,5-Pyrrolidinedione, 1-bromo- (9); (128-08-5) ...
cphE - Cyanophycinase precursor - Pseudomonas anguilliseptica - cphE gene & protein
100-43-6 - 4-Vinylpyridine, 95%, stab. with 80 to 150ppm hydroquinone - L13316 - Alfa Aesar
In the presence of NaOEt, thiols are protected as their S-2-(4-pyridyl)ethyl thioethers: J. Org. Chem., 51, 4914 (1986). Cleavage can be effected by methylation-hydrolysis: Tetrahedron Lett ., 25, 1223 (1984). Compare also 4-(2-Hydroxyethyl)-pyridine, L13780. Hofman, A. H.; van Ekenstein, G. O. R. A.; Woortman, A. J.; ten Brinke, G.; Loos, K. Poly(4-vinylpyridine)-block-poly(N-acryloylpiperidine) diblock copolymers: synthesis, self-assembly and interaction. Polym. Chem. 2015, 6 (39), 7015-7026.. Grochowicz, M.; Szajnecki, Ł.; Gawdzik, B. 4-Vinylpyridine-Trimethylolpropane Trimethacrylate Composite Polymer Particles and Their Application as Adsorbents. Adsorpt. Sci. Technol. 2015, 33 (6-8), 609-616.. ...
Oxidation7
- Kinetics and mechanism of micellar catalyzed N-bromosuccinimide oxidation of dextrose in H 2 SO 4 medium was investigated under pseudo-first-order condition temperature of 40°C. The results of the reactions studied over a wide range of experimental conditions show that NBS shows a first order dependence, fractional order, on dextrose and negative fractional order dependence on sulfuric acid. (hindawi.com)
- The proposed method is based on the oxidation of drug with N -bromosuccinimide and unreacted N -bromosuccinimide bleaches the blue color of methylene blue and is measured at 663 nm. (ijpsonline.com)
- N-bromosuccinimide effected oxidation of the tyrosine residues in cardiotoxin II with enhancement in absorbance at 260 nm. (ias.ac.in)
- In comparison with 0.01 N H 2 S O 4 , acetate-formate buffer could prevent secondary oxidations as revealed by lower consumption of oxidant, N-bromosuccinimide, to achieve oxidation. (ias.ac.in)
- Oxidation of cardiotoxin II with 3.75 equivalents of N-bromosuccinimide tyrosine residue led to complete loss of lethal activity. (ias.ac.in)
- Blocking of the exposed tryptophan by N -bromosuccinimide inhibited the oxidation of RNase and VA by MnP2 (VP), but its Mn 2+ -oxidizing activity was retained, suggesting that Trp-170 exposed on an enzyme surface is a substrate-binding site both for VA and the polymeric substrates. (portlandpress.com)
- The site to which the G-2 MAb bound was partially destroyed by sodium dodecyl sulfate and was resistant to oxidation with N-bromosuccinimide. (asm.org)
Bromination using N-bromosucci2
- 5""""""", 2"""""""']hexadecathiophene (4) by regioselective bromination using N-bromosuccinimide and regioselective lithiation using lithiumdiisopropylamide in ethylbenzene/THF/heptane followed by reaction with trimethyl-stannylchloride and subsequent palladium catalysed Stille coupling. (dtu.dk)
- Chiral bromosilanes have been prepared from prochiral dihydrosilanes by bromination using N-bromosuccinimide. (thefreedictionary.com)
Chem2
- How May We Serve You UIV CHEM N-Bromosuccinimide 128-08-5 in stock We can Supply HPLC\HMMR\MS report for you ,pls feel free to contact us! (lookchem.com)
- N-bromosuccinimide (Merck, Mumbai, India) and methylene blue (S.D. Fine Chem, Mumbai, India) were used for the experiment. (ijpsonline.com)
Synthesis5
- The use of N -bromosuccinimide enables a metal-free one-pot strategy for the synthesis of pharmaceutically important α-amino ketones from readily available benzylic secondary alcohols and amines. (organic-chemistry.org)
- A novel cationic Br initiated one-pot synthesis using olefin, nitrile, amine, and N -bromosuccinimide gives imidazolines in good yields. (organic-chemistry.org)
- Used by the pharmaceutical and chemical industries as an intermediary, N-bromosuccinimide serves as an oxidizing agent in the synthesis of drugs and hormones. (fsu.edu)
- For the laboratory synthesis of NBS, succinimide is dissolved in a solution of sodium hydroxide, ice, and water, then bromine is added, and the N-bromosuccinimide is filtered out as a precipitate. (fsu.edu)
- Yu,W.N Bromosuccinimide Mediated Radical Cyclization of 3 Arylallyl Azides: Synthesis of. (ourneighborhoodschool.com)
Tryptophan3
- Spande TF, Witkop B (1967) Determination of the tryptophan content of proteins with N -bromosuccinimide. (springer.com)
- Publications] 大西 正健: 'Effect of modification of tryptophan residues of cyclo=dextrin glucanotransferate with N-bromosuccinimide on the enzyme-catalyzed byelvolysis of Soluble Starch and cyclo wexcole. (nii.ac.jp)
- Publications] 大西 正健: 'Modification of tryptophan residues of cyclodextrin glucanotransfevase with N-bromosuccinimide on the formation of cycloamyloses from maltose as a sabstrate. (nii.ac.jp)
Reagent1
- N-Bromosuccinimide or NBS is a chemical reagent used in radical substitution, electrophilic addition, and electrophilic substitution reactions in organic chemistry. (wikipedia.org)
Reaction2
- Complete the mechanism and the products for the reaction of 2-pentene with N-bromosuccinimide (NBS). (transtutors.com)
- Reaction of alkenes with N-bromosuccinimide and Et3N.3HF produces vic-bromofluoroalkanes in high yields. (epfl.ch)
Zhang1
- JINGPING ZHANG: "N-Bromosuccinimide/l,8-Diazabicyclo[5.4.1] undec-7-ene Combination: P-Amination of Chalcones via a Tandem Bromoamination/Debromination Sequence", ORG. (sumobrain.com)
Tyrosine1
- The essential role of tyrosine residue(s) of cardiotoxin II in the biological activity of the toxin was evaluated using N-bromosuccinimide. (ias.ac.in)
Bromine3
- N -Bromosuccinimide (NBS) is a brominating and oxidizing agent that is used as source for bromine in radical reactions (for example: allylic brominations) and various electrophilic additions. (organic-chemistry.org)
- N-bromosuccinimide ( NBS ) is characterized by a molecular weight of 177.99, a chemical composition of 4 carbon, 4 hydrogen, 1 bromine, 1 nitrogen, and two oxygen atoms per molecule, and a faint bromine odor. (fsu.edu)
- The catalytic asymmetric bromoamination of chalcones with N -bromosuccinimide as both bromine and amide source was realized by using a chiral N , N ′-dioxide-Sc(NTf 2 ) 3 complex as an efficient catalyst. (rsc.org)
Brominations1
- Brominations with N-Bromosuccinimide and Related Compounds. (wikipedia.org)
Sodium dodecyl1
- The lethal activity was inactivated by N-bromosuccinimide, N-chlorosuccinimide, chloramine-T, and sodium dodecyl sulfate. (asm.org)
Dyes2
- Two sensitive spectrophotometric methods are presented for the assay of pantoprazole sodium sesqui hydrate (PNT) in bulk drug and in formulations using N-bromosuccinimide (NBS) and two dyes, methyl orange and indigo carmine, as reagents. (uni-mysore.ac.in)
- The methods use N-bromosuccinimide [NBS] and two- dyes , namely quinoline yellow and metanil yellow, as reagents . (bvsalud.org)
Compounds3
- An efficient one-pot transformation of β-hydroxycarbonyl compounds to α-brominated 1,3-dicarbonyl compounds is achieved with MoO 2 Cl 2 in the presence of N -bromosuccinimide. (organic-chemistry.org)
- N-haloamides, well known as N-bromosuccinimide, is a very important member of this class of compounds and has received a considerable attention as an oxidizing agent for a wide range of functional groups in both acidic and alkaline media [ 2 - 4 ]. (hindawi.com)
- with N-bromosuccinimide in an aprotic polar solvent, in the presence of a base to obtain the corresponding desired carbonyl compounds and/or their derivative. (sumobrain.com)
Reactions2
- Because many reactions involving N-bromosuccinimide are extremely exothermic, including violent or explosive reactions with aniline, diallylsulfide, hydrazine, and propiononitrile, special care is necessary for storage and handling. (fsu.edu)
- Reactions of (E)-cyclooctene with N-bromosuccinimide in the presence of water, and methanol, resp. (springer.com)
Determination1
- A. Ibrahim, A. Darwish Samiha, M. Hussein Ashraf, and I. Mahmoud Ahmed Hassan, "Sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol," International Journal of Biomedical Science , vol. 3, no. 2, pp. 123-130, 2007. (hindawi.com)
Ratio1
- The determined stoichiometric ratio was 1 : 1 (dextrose : N-bromosuccinimide). (hindawi.com)
Modification1
- Modification of the Streptomyces R61 DD-peptidase by N-bromosuccinimide resulted in a rapid loss of enzyme activity. (portlandpress.com)
Chemical1
- As a hazardous chemical, N-bromosuccinimide is harmful if swallowed, inhaled, or absorbed through the skin, and can cause severe irritation to skin, eyes, and the respiratory tract. (fsu.edu)
Water4
- An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N -bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. (organic-chemistry.org)
- N-bromosuccinimide (0.0067 mol/l) and methylene blue (0.031 mol/l) were prepared by dissolving 120 mg of N-bromosuccinimide and 1000 mg of methylene blue, respectively in distilled water and diluted to 100 ml. (ijpsonline.com)
- Aripiprazole (5-20 μg/ml)+1.0 ml of N-bromosuccinimide (0.0067 mol/l)+0.5 ml of methylene blue (0.01%)+diluted to 10 ml with distilled water. (ijpsonline.com)
- Appearing as an off-white powder, N-bromosuccinimide melts between 173 and 176 degrees Celsius, and is soluble in acetone and slightly soluble in water. (fsu.edu)
Market1
- In this report, the global N-Bromosuccinimide market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (rnrmarketresearch.com)
Treatment2
Title1
- 2002) with N -bromosuccinimide (NBS) and obtained the title compound in poor yield. (iucr.org)
Activities1
- Additives of Hg2+ and N- Bromosuccinimide strongly inhibited three xylanases activities. (ncl.edu.tw)