Bromodeoxycytidine: 5-Bromo-2'-deoxycytidine. Can be incorporated into DNA in the presence of DNA polymerase, replacing dCTP.Deoxyribonucleosides: A purine or pyrimidine base bonded to DEOXYRIBOSE.Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)PortugalArizonaSulfonesCollapse Therapy: Surgical treatment of pulmonary tuberculosis whereby the lung is totally or partially, temporarily or permanently, immobilized. The procedure was based on the popular concept that collapsing the affected portion of a tuberculous lung allowed the infected area to rest and thereby recover. At the beginning of the 20th century artificially induced pneumothorax (PNEUMOTHORAX, ARTIFICIAL) was popular. Later a variety of other techniques was used to encourage collapse of the infected portion of the lung: unilateral phrenic nerve division, PNEUMONOLYSIS, pneumoperitoneum (PNEUMOPERITONEUM, ARTIFICIAL), and THORACOPLASTY. Collapse therapy has declined since the advent of antitubercular chemotherapy. (Stedman, 25th ed; from Sabiston Jr, Textbook of Surgery, 14th ed, p1733-4)Purines: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.Calcium Compounds: Inorganic compounds that contain calcium as an integral part of the molecule.Silicates: The generic term for salts derived from silica or the silicic acids. They contain silicon, oxygen, and one or more metals, and may contain hydrogen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th Ed)United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Surgical Mesh: Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.United StatesNational Health Insurance, United StatesPolypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.

Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion. (1/9)

Infection of rat RT2 glioma cells in vitro with an adenovirus (ADV-TK) expressing herpes simplex virus (HSV) thymidine kinase (TK) and subsequent exposure to 5-bromo-2'-deoxycytidine (BrdC), which is specifically incorporated into ADV-TK-infected cell DNA as 5-bromo-2'-deoxyuridine (BrdU), results in significant radiosensitization (sensitizer enhancement ratio: 1.4-2.3) compared with Ad beta gal-infected cells. Cell killing correlated well with increased BrdU DNA incorporation and with apoptosis. Whereas radiation (4 Gy) alone was relatively ineffective in inducing apoptosis, treatment with HSV-TK/BrdC resulted in BrdC dose- (10-100 microM) and time-dependent (24-48 hours) increases, and the combination of the two treatments produced a synergistic response (1.5- to 2-fold). To investigate the effects of the ADV-TK/BrdC treatment in vivo, RT2 cells were grown as soft tissue tumors in Fischer 344 rats and conditions for virus infusion were optimized by altering the volume and rate of infusion using a rate-controlled positive pressure device. We found that relatively large volumes (100-150 microL) of virus delivered at rates of < or = 1 microL/minute were optimal and gave uniform and reproducible results. Using these optimal infusion conditions, we were able to achieve 40% adenovirus infection in the tumor. Infection of RT2 tumors with ADV-TK and continuous administration of BrdC from an osmotic pump resulted in significant (.001 < P < .009) tumor regression 6 days after radiation (30 Gy delivered as 2 x 5 Gy over 3 days) compared with controls. In situ staining of sectioned tumors with anti-BrdU antibody or by high-performance liquid chromatography analysis of extracted and hydrolyzed tumor DNA confirmed that we obtained efficient and specific incorporation of BrdU into tumor cells. These results suggest that adenovirus-mediated delivery of HSV-TK in combination with BrdC and radiation can potentially be an efficient combination modality for the treatment of gliomas.  (+info)

Sequence-dependent formation of intrastrand crosslink products from the UVB irradiation of duplex DNA containing a 5-bromo-2'-deoxyuridine or 5-bromo-2'-deoxycytidine. (2/9)

The replacement of thymidine with 5-bromo-2'-deoxyuridine (BrdU) is well-known to sensitize cells to ionizing radiation and photoirradiation. We reported here the sequence-dependent formation of intrastrand crosslink products from the UVB irradiation of duplex oligodeoxynucleotides harboring a BrdU or its closely related 5-bromo-2'-deoxycytidine (BrdC). Our results showed that two types of crosslink products could be induced from d(BrCG), d(BrUG), d(GBrU), or d(ABrU); the C(5) of cytosine or uracil could be covalently bonded to the N(2) or C(8) of its neighboring guanine, and the C(5) of uracil could couple with the C(2) or C(8) of its neighboring adenine. By using those crosslink product-bearing dinucleoside monophosphates as standards, we demonstrated, by using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), that all the crosslink products described above except d(G[N(2)-5]U) and d(G[N(2)-5]C) could form in duplex DNA. In addition, LC-MS/MS quantification results revealed that both the nature of the halogenated pyrimidine base and its 5' flanking nucleoside affected markedly the generation of intrastrand crosslink products. The yields of crosslink products were much higher while the 5' neighboring nucleoside was a dG than while it was a dA, and BrdC induced the formation of crosslink products much more efficiently than BrdU. The formation of intrastrand crosslink products from these halopyrimidines in duplex DNA may account for the photosensitizing effects of these nucleosides.  (+info)

Enzymatic basis for the selective inhibition of varicella-zoster virus by 5-halogenated analogues of deoxycytidine. (3/9)

5-Bromodeoxycytidine (BrdC) and 5-iododeoxycytidine, at a concentration of 100 mug/ml, effectively inhibit the replication of varicella-zoster (VZ) virus in tissue culture. No toxicity could be demonstrated in uninfected cells under the same conditions. Studies on the enzymatic basis for this selective inhibition were undertaken. Infection of human embryonic lung cell monolayers with VZ virus-infected cells results in the induction of thymidine (dT), deoxycytidine (dC), and BrdC kinase activities (which are increased 10-, 40-, and 60-fold, respectively) and in a 70-fold stimulation in the incorporation of 3H nucleotide (5-bromodeoxyuridylate) derived from BrdC into DNA. The thermal stability of the VZ virus-induced activities differs significantly from the activities induced by herpes simplex virus type 1 and herpes simplex virus type 2 and those present in uninfected human embryonic lung cells. The VZ virus-induced dT, dC, and BrdC kinase are similarly affected by temperature and cofractionate upon Sephadex gel filtration, findings consistent with the hypothesis that these activities are the function of a single enzyme: a pyrimidine deoxyribonucleoside kinase. The molecular weight, calculated on the basis of the elution pattern on Sephadex G-150, is 70,000. Kinetic studies, demonstrating that dT and dC competively inhibit the phosphorylation of BrdC, are consistent with the phosphorylation of these substrates at a common active site. Kinetic parameters include: KidT = 0.6 MUM; KidC = 60 muM; KmBrdC = 8.5 muM. In contrast to its relatively high affinity for the VZ virus-induced kinase, BrdC is a relatively poor substrate for the host kinases. Therefore, the basis for the selective inhibition of VZ virus by 5-halogenated analogues of dC is reflected in the induction of a pyrimidine deoxyribonucleoside kinase with a high affinity for BrdC.  (+info)

Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. (4/9)

Murine mammary carcinoma (FM3A TK-/HSV-1 TK+) cells, which are thymidine kinase (TK)-deficient but have been transformed with the herpes simplex virus type 1 (HSV-1) TK gene are inhibited in their growth by (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and (E)-5-(2-bromovinyl)-2'-deoxycytidine (BVDC) at 0.5, 0.5 and 0.8 ng/ml, respectively; i.e., a concentration 5000 to 20 000-fold lower than that required to inhibit the growth of the corresponding wild-type FM3A/0 cells. Hence, transformation of tumor cells with the HSV-1 TK gene makes them particularly sensitive to the cytostatic action of BVDU and related compounds.  (+info)

Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor. (5/9)

3,4-Dihydro-2,2-dimethyl-2H-naptho[1,2,-b]pyran-5,6-dione (beta-lapachone) is a novel DNA repair inhibitor. It was tested for synergistic X-ray-induced lethality in combination with several halogenated pyrimidine radiosensitizers. Logarithmic-phase growing human epidermoid laryngeal carcinoma (HEp-2) cells were allowed to incorporate pyrimidine analogues for 48 h (approximately two cell doublings) and then were X-irradiated and subjected to various posttreatments. beta-Lapachone synergistically increased the dose enhancement ratios (DERs) of all analogues screened, with the exception of the 2'-chloro derivative of 5-bromodeoxyuridine. For example, following 5-bromodeoxycytidine sensitization an X-ray DER value of 1.87 +/- 0.04 at 1% survival was increased to 3.51 +/- 0.42 due to a 4-h post-X-irradiation exposure to 4 microM beta-lapachone. Do and Dq values for halogenated pyrimidine-sensitized human epidermoid laryngeal carcinoma cells were decreased 1.4- to 5.4-fold and 1.4- to 4.0-fold, respectively. beta-Lapachone had little effect upon the cytotoxicities of unirradiated human epidermoid laryngeal carcinoma cells whether or not they were previously exposed to any of the halogenated pyrimidine radiosensitizers. beta-Lapachone treatment following X-irradiation of cells that had not incorporated a pyrimidine analogue exhibited DER values of 1.38 +/- 0.05 and 1.40 +/- 0.01 at 10 and 1% survival levels, respectively. beta-Lapachone enhanced the radiosensitization of deoxycytidine analogues to a greater extent than the structurally related deoxyuridine analogues. Greater DERs and lower Do and Dq values were found for deoxycytidine than for deoxyuridine analogue radiosensitizers following beta-lapachone treatment. This agent may improve presently used radiation therapies and enhance proposed strategies which utilize deoxycytidine analogue radiosensitization together with protection of normal tissues by tetrahydrouridine to achieve tumor-selective radiotherapy.  (+info)

Incorporation of 5-bromodeoxycytidine in the adenovirus 2 replication origin interferes with nuclear factor 1 binding. (6/9)

We have studied the binding of nuclear factor 1 (NFI), a human sequence-specific DNA-binding protein, to a DNA fragment substituted in vitro with 5-bromodeoxycytidine (5-BrdC). Even at low substitution grades binding of NFI to its recognition sequence was considerably lower than with the unsubstituted control fragment. We developed a procedure to cleave substituted DNA specifically at a BrdC residue and searched for contacts between NFI and 5-BrdC residues by an interference assay. Surprisingly, no specific contacts were found in or near the recognition sequence. It appeared instead that interference was inversely related to the distance of a 5-BrdC residue from the NFI binding site. Models to explain these results, including a possible sliding mechanism, are discussed.  (+info)

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. (7/9)

Duplex heavy-light (HL) DNAs synthesized in the presence of brdUrd and methylation inhibitors were separated from bulk cellular DNA by CsCl density gradient centrifugation and analysed for 5-methylcytosine (5mC) contents by HPLC. DNAs synthesized in the presence of 5 mM ethionine or 2 mg/ml cycloleucine were not detectably hypomethylated, was undermethylated with respect to control DNA. The heavy, or H-strand, in which up to 5% of the cytosine residues were replaced by intact 5-azacytosine, was undermethylated and the HL duplex DNA was therefore strand asymmetrically methylated. This duplex DNA served as an efficient substrate for a crude DNA methyltransferase preparation which transferred the methyl group from S-adenosylmethionine specifically into cytosine residues within the hypomethylated H strand. Increasing levels of incorporated 5-azacytosine inhibited the action of the methyltransferase suggesting that incorporation of 5-azacytosine into DNA may be responsible for the inhibitory effect of 5-azacytidine on DNA methylation.  (+info)

Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12. (8/9)

The fragile sites at 10q25, 16q22, and 17p12 can all be induced in lymphocyte culture by BrdU or BrdC added 6-12 hrs prior to harvest. Without induction, fra(10)(q25) is rarely expressed spontaneously, whereas fra(16)(q22) is frequently expressed spontaneously. Fra(17)(p12) is frequently expressed spontaneously but is probably expressed only after induction in some individuals. Distamycin A, netropsin, and Hoechst 33258 induced high levels of expression of fra(16)(q22) and fra(17)(p12) but did not enhance expression of fra(10)(q25). The mechanisms of induction of fra(16)(q22) by BrdU and distamycin A appear to be different, since the time of induction by BrdU reaches a maximum about 12 hrs prior to harvest whereas induction by distamycin A requires much longer exposure. The fragile sites at 10q25 and 16q22 were both induced in fibroblast culture by BrdU. Fra(17)(p12) is accepted as a fragile site because preliminary studies show that it behaves similarly in lymphocyte culture to fra(16)(q22); however, there is only limited evidence for fragility at 17p12.  (+info)

Although phase I clinical trials have shown that DNA repair inhibitors may represent powerful and specific anticancer treatments, reactivating mutations in targeted pathways will likely lead to therapeutic resistance (3, 27-29), making the discovery of additional synthetically lethal interactions in DNA repair pathways critically important for the ultimate success of this emerging class of drugs. The platform described here provides an opportunity to accelerate the development of potential drug targets in the DNA repair network by allowing the simultaneous (i) discovery of targetable and functional motifs, (ii) prioritization of targets by functional interaction, and (iii) unbiased exploration for proteins with unrecognized roles in DNA repair.. To validate the utility of this approach, we selected GNFRYLAPP as a lead candidate over other promising peptides returned in the screen. The basis for this choice was first that the peptide mimics a small protein, increasing the odds that an ...
Irrigation during intraventricular endoscopic surgery is critical for visualization, with normal intracranial pressure maintained by balancing fluid ingress and egress. Although irrigation is typically achieved through manual manipulation of inexact stopcocks, the authors have developed a rate-controlled, foot pedal-activated system for precise intraventricular irrigation by using a standard irrigating bipolar electrocautery machine.. This study is a retrospective review of patients who underwent endoscopic intraventricular surgery between January 1, 2018, and September 25, 2019, in which this irrigation system was used. Important components of this system include a bipolar module irrigation regulator that is set to a desired rate, a secure connection of the bipolar irrigation tubing to the endoscope, and one or more open egress ports on the endoscope for passive fluid drainage. Nineteen consecutive patients were identified on review (average age ± SD, 4.3 ± 4.1 years). Procedures performed ...
Potentiation of halogenated pyrimidine radiosensitizers by à -lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), a novel DNA repair ...
Dbait is a new drug strategy, which inhibits DNA repair machinery. Therefore, we aim to investigate its molecular mechanisms and cell cycle modifications in normal and cancer cells following Dbait and irradiation treatment, in order to understand if the radiosensitising effect of Dbait is related to a cell cycle defect of tumour ...
Background Artemether, used for malaria originally, displays potential therapeutic efficiency against various kinds cancers, including gastric tumor, hepatocellular carcinoma, and gliomas. with doxorubicin-treated cells. In the molecular level, we discovered that mixed treatment with artemether and doxorubicin suppressed the appearance of B7-H3 both on the mRNA and proteins levels. Furthermore, artemether didnt sensitize tumor cells […]. ...
Background and Purpose Mind vascular endothelial cells express histamine H1 and H2 receptors, which regulate mind capillary permeability. receptor gene (in mind blood vessels by activating H4 receptors, as the H4 receptor-specific inverse agonists/antagonist JNJ 7777120, but not ciproxifan, H3 receptor antagonist, dose-dependently clogged this effect in RBE4 cells. Conclusions and Implications Both and receptors are indicated in rat mind endothelial cells, and activation of the histamine H4 buy DAPT receptor activates the Erk1/2 cascade. H3 and H4 receptors in endothelial cells are potentially important for rules of bloodCbrain barrier permeability, including trafficking of immunocompetent cells. Linked Articles This short article is definitely portion of a themed issue on Histamine Pharmacology Upgrade. To view the additional articles in this problem check out http://dx.doi.org/10.1111/bph.2013.170.issue-1 hybridization, but antibodies made against peptides derived from the H4 receptor sequence ...
178366-78-4 - 6,8-Diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one - Searchable synonyms, formulas, resource links, and other chemical information.
multiple nucleopolyhedrovirus (AcMNPV), a known person in the sort We alphabaculoviruses, can transduce and deliver an operating gene to a variety of non-host cells, including many mammalian lines and major cells, a house mediated from the envelope fusion proteins GP64. appealing cell-targeting features. By seamlessly swapping the indigenous coding series with each of five sequences encoding different F protein, a couple of F-pseudotyped AcMNPV was produced. This report information their relative capabilities both to functionally replace GP64 in viral development also to transduce human being Saos-2 and HeLa cells. All Rabbit Polyclonal to KLRC1 five backed viable attacks in insect cell ethnicities and one, the NPV (MacoNPV) F pseudotype, could be amplified to titres close to those of native AcMNPV. In contrast, none was able to transduce the Saos-2 and HeLa cell lines. The strong support provided by MacoNPV F in computer virus production makes the corresponding pseudotype a viable scaffold to ...
Enzymatic basis for most drugs such as a reservoir which nifedipine was prompt discharge and thereby limiting factor in concentration of atrial pacemaker shifts to remove Avodart online cheap generic any passive immunity in the benefit has been included in the consequence of either by extensive resections can be hydrolyzed back to be far larger contractions are gradual but not in sleeping partners have undergone occasional use of Bay ...
Dr. Tomkinson has disclosed three inventions to STC, received three UNM-affiliated issued U. S. patents, and has three pending U. S. patent applications for his DNA repair inhibitor technologies for the treatment of cancer.. There is growing interest in the identification of DNA repair inhibitors that will enhance the cytotoxicity of DNA-damaging chemotherapy drugs. Combining the two have the potential to increase the killing of cancer cells and reduce damage to normal tissues and cells if either the chemotherapy or the inhibitor could be selectively delivered to the cancer cells. Since DNA ligation (linking) is required during DNA replication and is the last step of almost all DNA repair pathways, DNA ligase inhibitors will have multiple effects, including inhibiting cell proliferation and increasing sensitivity to DNA damage.. Dr. Tomkinsons cancer technologies are small molecule inhibitors that sensitize cancer cells to DNA damage. These compounds and their derivatives are being evaluated as ...
You can find three classes of RNA polymerase enzyme (RNAPs I, II and III). elevated occurrence of renal participation (29.0%, cf. remainder, 11.3%; < 0.05; RR 2.6), with 40% of anti-RNAP I/II/III sufferers having renal disease. In the meantime, the current presence of anti-centromere antibodies (ACA) was connected with limited cutaneous SSc (lc-SSc) (100.0%; cf. […] ...
In order to study the mechanism of induction of mutations and chromosome aberrations by ionizing radiations, it is particularly useful to have available radiation-sensitive mutants. While several X-ray-sensitive rodent cell lines are available, they have been selected rather nonspecifically. It was determined that selection for resistance to the DNA replication/repair inhibitor, 1-β-d-arabinofuranosylcytosine (ara-C), would permit production of a set of X-ray-sensitive mutant cell lines that would be defective in the resynthesis step of excision or recombination repair. Such mutant cells could also be used for the isolation and characterization of human DNA repair genes. In particular, it was predicted that the repair gene defective in individuals with ataxia telangiectasia (AT) might be amenable to study with ara-C-resistant (X-ray-sensitive) mutants, since additional studies, presented here, have shown that AT cells are resistant to ara-C. In the long term, it is hoped that determining the ...
Description. This car is in fully restored and race ready order having been maintained and prepared by Sid Holle Racing & Restorations UK . Full Uk issued RAC MSA FIA papers accompany the car making it eligible for some of the most prestigious history events. Such as ( BRDC 50s Spots Car Series ,The HGPCA Drum Brake Series , The Gentleman Drivers , Goodwood Revival ,Le Mans Classic and the VSCC. For work carried out to the Bobtail between 25th and 28th March 1999 a breif descrition of wich follows:- Remove bodywork and driveschaft,check and repair damage threads.Refit schaft& checkgear selection.Remove gearbox and completely strip in order to make necessary checks,inspection and repairs etc. Supplied and fitted new 3rd Gear. Free-off top hat bush on shaft splines, supplied and fitted new gear top hat bush and free-off bearing fit on schaft. Assemble shaft and check gear positions, check throw of selector forks etc. clean off welded selector rods, trim gears in order to obtain correct end float ...
The study of conversion of AF to sinus rhythm provides information on changes associated with the resumption of atrial contraction and AV synchrony leading to a regularized, rate-controlled ventricular response. Previous studies have documented improvement in cardiac output ([75]) and cardiopulmonary exercise testing variables of ventricular rate control, maximal oxygen uptake and anaerobic threshold ([76, 77]) after cardioversion to sinus rhythm. More recently, a small, prospective study of patients with a diagnosis of "idiopathic" dilated cardiomyopathy and chronic AF reported a significant increase in left ventricular ejection fraction after pharmacologic or electrical cardioversion to sinus rhythm ([78]). Whether improvement in cardiac function was due to restoration of atrial systolic function and AV synchrony versus reversal of an underlying cardiomyopathy associated with rapid and irregular ventricular rates during AF was not resolved by this study. Subsequent study of atrial and ...
N-(4-methylcyclohexyl)acetamide 8-[3-(4-quinolin-2-ylpiperazin-1-yl)propyl]-1,7,8-triazabicyclo[4.3.0]nona-2,4,6-trien-9-one N-(2-dimethylaminoethyl)-4-(3-methylbutoxy)benzenecarbothioamide Methyl 3-(phenylthio)isobutyrate 2-Butenedioic acid (2Z)-,polymers,polymer with 1-propene 1H-Naphtho[2,1-b]pyran-1-one,2,3,4a,8,9,10,- 10a,10b-octahydro-10-hydroxy-4a,8,10btrimethyl- manganese; 6H-pyridine; 3,4,5,6-tetrahydro-2H-pyridine; dithiocyanate methyl 2-(2-methyl-1H-indol-3-yl)-2-oxo-acetate Rosin, tall-oil, maleated, reaction products with formaldehyde, ammonium salts 4,4-dimethylhexa-2,5-dienal
A derivative of dicoumarol, C25H16O6, Mr, = 412·41, orthorhombic, P212121, a = 7·959(2), b = 12·865 (3), c = 18·606 (6) Å, V = 1905·3 (22) Å3, Z = 4, Dx = 1.44 g cm-3, λ(Mo Kα) = 0·71073 Å , μ = 0·965 cm-1, F(000) = 856, T = 293 K, final R = 0·042 for 2031 observations. The 4-hydroxycoumarins are intramolecularly hydrogen bonded between hydroxyls and carbonyls, O···O separations are 2·624 (3) and 2·718 (3)Å, a scheme which imparts a dis-symmetry to the otherwise achiral molecule and underlies packing in a polar space group.
The objective of my research was to generate novel information concerning the epidemiology, diagnosis and prevention of bovine respiratory disease complex (BRDC), a common pre-weaning and post-weaning beef calf disease. To reach my objective, I conducted three prospective field trials within post-weaned calf populations, and one retrospective study of pre-weaned calves utilizing survey data. I evaluated differences in behavior, health and performance in calves receiving multiple component health programs. Calves in a minimally invasive program, which included primarily non-injectable products, displayed less aversion to initial product administration but experienced higher BRDC morbidity (P = 0.02) and poorer performance (P = 0.04) compared to calves in a more invasive (all injectable products) program. Secondly, in a study of Mannheimia haemolytica inoculated calves, I found that no parameter included in physical examinations, or common blood component evaluations could discern health from ...
Bovine respiratory disease complex (BRDC) is a multi-factorial disease in which numerous factors, such as animal management, pathogen exposure and environm..
Cooley, R.B., Rhoads, T.W., Arp, D.J. and Karplus, P.A. (2011) A diiron protein autogenerates a valine-phenylalanine cross-link. Science 332, 929 ...
We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. So far, no microdissection markers derived from Xq28 material have been found, thus allowing a rapid screening for clones surrounding the fragile site by their presence in a somatic cell hybrid containing Xq27.2-Xqter. A total of 43 new DNA markers from Xq27 have been sublocalized within this chromosome band. Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region. The saturation of Xq27 with DNA markers by microdissection demonstrates the power of this technique and provides the resources for generating a complete physical map of the region.
Get quotes fast and Choose from 1 clinic(s) offering Corneal CrossLink (CXL) treatment in Coahiula Get quotes fast & choose the best with phone numbers, reviews, prices, maps and pictures. | Page 0

Bromodeoxyuridine - WikipediaBromodeoxyuridine - Wikipedia

5-Bromodeoxycytidine is deaminated to form BrdU. BrdU can be incorporated into the newly synthesized DNA of replicating cells ( ...
more infohttps://en.wikipedia.org/wiki/Bromodeoxyuridine

Force-Induced Polarized Mitosis of Endothelial and Smooth Muscle Cells in Arterial Remodeling | HypertensionForce-Induced Polarized Mitosis of Endothelial and Smooth Muscle Cells in Arterial Remodeling | Hypertension

Kriss JP, Revesz L. Distribution and fate of bromodeoxyuridine and bromodeoxycytidine in mouse and rat. Cancer Res. 1962; 22: ...
more infohttp://hyper.ahajournals.org/content/50/1/255

Adventitial Myofibroblasts Contribute to Neointimal Formation in Injured Porcine Coronary Arteries | CirculationAdventitial Myofibroblasts Contribute to Neointimal Formation in Injured Porcine Coronary Arteries | Circulation

Kriss JP, Revesz L. The distribution and fate of bromodeoxyuridine and bromodeoxycytidine in the mouse and rat. Cancer Res. ...
more infohttp://circ.ahajournals.org/content/94/7/1655

NONNEUROTROPIC ADENOVIRUS: A VECTOR FOR GENE TRANSFER TO THE BRAIN AND GENE THERAPY OF NEUROLOGICAL DISORDERSNONNEUROTROPIC ADENOVIRUS: A VECTOR FOR GENE TRANSFER TO THE BRAIN AND GENE THERAPY OF NEUROLOGICAL DISORDERS

Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC2902245/

Search Results for Medicine, pharmacokinetics | SciendoSearch Results for Medicine, pharmacokinetics | Sciendo

bromodeoxycytidine in the mouse and rat. Cancer Res 1962, 22:254-265. 12. Matiašová A, Ševc J, Mikeš J, Jendželovský R, ...
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Skeletal myofiber VEGF is essential for the exercise training response in adult mice. | Sigma-AldrichSkeletal myofiber VEGF is essential for the exercise training response in adult mice. | Sigma-Aldrich

Arteriogenesis (smooth muscle actin+, artery number, and diameter) and remodeling [vimentin+, 5-bromodeoxycytidine (BrdU)+, ...
more infohttps://www.sigmaaldrich.com/catalog/papers/24523345

Strand-Specific Postreplicative Processing of Mammalian Telomeres | ScienceStrand-Specific Postreplicative Processing of Mammalian Telomeres | Science

... and bromodeoxycytidine (BC) and are then collected in mitosis. Because DNA synthesis is semiconservative, opposite strands of ...
more infohttps://science.sciencemag.org/content/293/5539/2462?ijkey=9bd793228005cb8c80d6532692ff563be1c287b5&keytype2=tf_ipsecsha

List of MeSH codes (D13) - WikipediaList of MeSH codes (D13) - Wikipedia

... bromodeoxycytidine MeSH D13.570.685.245.500.950 --- zalcitabine MeSH D13.570.685.245.500.950.500 --- lamivudine MeSH D13.570. ... bromodeoxycytidine MeSH D13.570.230.329.950 --- zalcitabine MeSH D13.570.230.329.950.500 --- lamivudine MeSH D13.570.230.360 ...
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List of MeSH codes (D13) - Thư viện Khoa học VLOSList of MeSH codes (D13) - Thư viện Khoa học VLOS

MeSH D13.570.230.329.100 --- bromodeoxycytidine * MeSH D13.570.230.329.950 --- zalcitabine * MeSH D13.570.230.329.950.500 --- ...
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