Bromocriptine. Medical search

A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.

A series of structurally-related alkaloids that contain the ergoline backbone structure.

A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.

A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.

An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).

Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Drugs that bind to and activate dopamine receptors.

Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.

Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.

Excessive or inappropriate LACTATION in females or males, and not necessarily related to PREGNANCY. Galactorrhea can occur either unilaterally or bilaterally, and be profuse or sparse. Its most common cause is HYPERPROLACTINEMIA.

A dopamine D2 antagonist that is used as an antiemetic.

A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.

Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.

The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)

Small clusters of chemoreceptive and supporting cells located near the ARCH OF THE AORTA; the PULMONARY ARTERIES; and the CORONARY ARTERIES. The aortic bodies sense PH; CARBON DIOXIDE; and OXYGEN concentrations in the BLOOD and participate in the control of RESPIRATION. The aortic bodies should not be confused with the PARA-AORTIC BODIES in the abdomen (which are sometimes also called aortic bodies).

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.

A group of corticosteroids bearing a hydroxy group at the 11-position.

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.

Absence of menstruation.

A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.

Disturbances of MILK secretion in either SEX, not necessarily related to PREGNANCY.

A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)

A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Drinkable liquids combined with or impregnated with carbon dioxide.

A plant genus of the family VALERIANACEAE, order Dipsacales, subclass Asteridae, class Magnoliopsida. It is best known for the sedative use and valepotriate content of the roots. It is sometimes called Garden Heliotrope but is unrelated to true Heliotrope (HELIOTROPIUM).

A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.

Glucose in blood.

The only living genus of the order Equisetales, class Equisetopsida (Sphenopsida), division Equisetophyta (Sphenophyta); distantly related to ferns. It grows in moist places. The hollow, jointed, ridged stems contain SILICATES.

A genus of plant viruses in the family BUNYAVIRIDAE. Tomato spotted wilt virus is the type species. Transmission occurs by at least nine species of thrips.

A subset of various vascular plants (also known as the Tracheophyta) which include seed-bearing and non seed-bearing species.

A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

A professional society in the United States whose membership is composed of hospitals.

Organizations and individuals cooperating together toward a common goal at the local or grassroots level.

Institutional systems consisting of more than one health facility which have cooperative administrative arrangements through merger, affiliation, shared services, or other collective ventures.

It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)

A malignant neoplasm of the lung composed chiefly or entirely of immature undifferentiated cells (i.e., blast forms) with little or virtually no stroma. (From Stedman, 25th ed)

Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).

Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.

Infection with TREMATODA of the genus PARAGONIMUS.

Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (1/485)

LEK-8829 [9,10-didehydro-N-methyl-(2-propynyl)-6-methyl-8- aminomethylergoline bimaleinate] is an antagonist of dopamine D2 receptors and serotonin (5-HT)2 and 5-HT1A receptors in intact animals and a D1 receptor agonist in dopamine-depleted animals. In the present study, we used rats with unilateral striatal lesions with ibotenic acid (IA) to investigate the dopamine receptor activities of LEK-8829 in a model with innervated dopamine receptors. The IA-lesioned rats circled ipsilaterally when challenged with apomorphine, the mixed agonist on D1/D2 receptors. LEK-8829 induced a dose-dependent contralateral turning that was blocked by D1 receptor antagonist SCH-23390. The treatment with D1 receptor agonist SKF-82958 induced ipsilateral turning, whereas the treatment with D2 receptor antagonist haloperidol induced contralateral posture. The combined treatment with SKF-82958 and haloperidol resulted in a weak contralateral turning, indicating the possible receptor mechanism of contralateral turning induced by LEK-8829. Bromocriptine induced a weak ipsilateral turning that was blocked by haloperidol. The ipsilateral turning induced by bromocriptine was significantly potentiated by the coadministration of a low dose but not by a high dose of LEK-8829. The potentiation of turning was blocked either by SCH-23390 or by haloperidol. The potentiation of ipsilateral turning suggests the costimulation of D2 and D1 receptors by bromocriptine and LEK-8829, respectively, whereas the lack of potentiation by the highest dose of LEK-8829 may be explained by the opposing activity of LEK-8829 and bromocriptine at D2 receptors. We propose that the D2 and 5HT2 receptor-blocking and D1 receptor-stimulating profile of LEK-8829 is promising for the treatment of negative symptoms of schizophrenia. (+info)

Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors. (2/485)

The gamma-aminobutyric acid type A (GABAA) receptor is the predominant Cl- channel protein mediating inhibition in the olfactory bulb and elsewhere in the mammalian brain. The olfactory bulb is rich in neurons containing both GABA and dopamine. Dopamine D1 and D2 receptors are also highly expressed in this brain region with a distinct and complementary distribution pattern. This distribution suggests that dopamine may control the GABAergic inhibitory processing of odor signals, possibly via different signal-transduction mechanisms. We have observed that GABAA receptors in the rat olfactory bulb are differentially modulated by dopamine in a cell-specific manner. Dopamine reduced the currents through GABA-gated Cl- channels in the interneurons, presumably granule cells. This action was mediated via D1 receptors and involved phosphorylation of GABAA receptors by protein kinase A. Enhancement of GABA responses via activation of D2 dopamine receptors and phosphorylation of GABAA receptors by protein kinase C was observed in mitral/tufted cells. Decreasing or increasing the binding affinity for GABA appears to underlie the modulatory effects of dopamine via distinct receptor subtypes. This dual action of dopamine on inhibitory GABAA receptor function in the rat olfactory bulb could be instrumental in odor detection and discrimination, olfactory learning, and ultimately odotopic memory formation. (+info)

Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. (3/485)

Hypothalamic disease often affects the patients' personality and this also applies to pituitary tumors with suprasellar extension. We report on a patient with a 12-year history of recurrent acromegaly, treated with three transphenoidal operations, single field radiation therapy and bromocriptine/octreotide administration. During the course of follow-up she presented with self-inflicted anemia and Kleine-Levin syndrome (hypersomnia, hyperphagia and hypersexuality). Furthermore, she developed post-radiation necrosis within the right temporal lobe. Whether her neurological and personality disorders result - at least partially - from the acromegaly or the temporal lobe necrosis remains unclear. (+info)

The lipoprotein profile of women with hyperprolactinaemic amenorrhoea. (4/485)

The aim of this study was to evaluate the lipoprotein profile in women with hyperprolactinaemic amenorrhoea and to establish whether effective dopamine agonist therapy might have a beneficial effect. Blood samples were collected from women with hyperprolactinaemic amenorrhoea and from controls matched for age, body mass index and smoking. Follow-up blood samples were collected from women on dopamine agonist therapy as treatment for their hyperprolactinaemia. Plasma cholesterol, high density lipoprotein cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein cholesterol, triglycerides, serum oestradiol and prolactin were measured. No statistically significant differences were found in the lipoprotein profile of the patient (n = 15) and control (n = 15) groups. During treatment with the dopamine agonist, bromocriptine (n = 9), significant reduction in total cholesterol [4.87 (3.98-5.87) versus 5.60 (4.55-6.61) mmol/l, P = 0.024] and LDL cholesterol [3.22 (2.01-4.23) versus 3.72 (2.59-4.93) mmol/l, P = 0.033] was noted. We conclude that beneficial alterations in the lipoprotein profile may occur in response to effective dopamine agonist therapy, presumably as a consequence of return of ovarian function and alleviation of oestrogen deficiency. Women with hyperprolactinaemic amenorrhoea should be encouraged to take effective therapy to improve their lipoprotein profile and potentially reduce their cardiovascular risk. (+info)

Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha1D Ca2+ channel gene expression. (5/485)

Hormones and neurotransmitters have both short-term and long-term modulatory effects on the activity of voltage-gated Ca2+ channels. Although much is known about the signal transduction underlying short-term modulation, there is far less information on mechanisms that produce long-term effects. Here, the molecular basis of long-lasting suppression of Ca2+ channel current in pituitary melanotropes by chronic dopamine exposure is examined. Experiments involving in vivo and in vitro treatments with the dopaminergic drugs haloperidol, bromocriptine, and quinpirole show that D2 receptors persistently decrease alpha1D L-type Ca2+ channel mRNA and L-type Ca2+ channel current without altering channel gating properties. In contrast, another L-channel (alpha1C) mRNA and P/Q-channel (alpha1A) mRNA are unaffected. The downregulation of alpha1D mRNA does not require decreases in cAMP levels or P/Q-channel activity. However, it is mimicked and occluded by inhibition of L-type channels. Thus, interruption of the positive feedback between L-type Ca2+ channel activity and alpha1D gene expression can account for the long-lasting regulation of L-current produced by chronic activation of D2 dopamine receptors. (+info)

Reduction of plasma gonadotropin levels and pituitary tumor size by treatment with bromocriptine in a patient with gonadotropinoma. (6/485)

A pituitary tumor with suprasellar extension was found by magnetic resonance imaging (MRI) in a male with diabetes mellitus. Endocrine examination revealed high plasma follicle-stimulating hormone (FSH) and alpha-subunit levels, which increased with administration of thyrotropin (TSH)-releasing hormone (TRH). Plasma luteinizing hormone (LH) and testosterone levels were low. Pituitary gonadotropin producing tumor was diagnosed. Because the patient refused surgery, bromocriptine was administered and plasma FSH and alpha-subunit rapidly decreased; on MRI the tumor size was gradually reduced. When pituitary operation is not feasible, bromocriptine is one choice of treatment. (+info)

Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak. (7/485)

Since structural luteolysis involves deterioration of tissue, the gene expression of matrix-metalloproteinase-1 (MMP-1) and the respective tissue inhibitor of this metalloprotease (TIMP-1) were measured at various times on the day of pro-oestrus and in animals in which the preovulatory prolactin surge was blocked for the duration of 3 cycles by bromocriptine. An additional group of prolactin-blocked rats received a prolactin replacement injection on the afternoon of pro-oestrus. In spontaneously pro-oestrous rats, MMP-1 and TIMP-1 gene expression increased significantly (P<0.01) prior to the occurrence of the preovulatory LH surge but simultaneously with the onset of the preovulatory prolactin surge. When prolactin release was blocked by bromocriptine for 3 cycles, no such changes were observed during the afternoon of pro-oestrus. However, an intraperitoneal injection of bovine prolactin at the time when the preovulatory prolactin surge occurs normally, increased MMP-1 and TIMP-1 gene expression (P<0.01). These results indicate that MMP-1 and TIMP-1 gene expression are stimulated by the preovulatory prolactin surge. Previous work has shown that the preovulatory LH surge activates the enzymatic cascade which leads to increased collagenase activity. (+info)

Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa. (8/485)

Thirty-seven patients with Parkinsonism were treated with bromocriptine 2.5-300 mg daily. Bromocriptine, alone or combined with levodopa, caused a 20-30% reduction in disability scores in 11 patients treated for one year. Tolerance did not develop during this period. Bromocriptine treatment was not of value in six patients who had previously not responded or who had lost their response to levodopa. However, in four of five patients with response swings on levodopa due to rapid changes in plasma dopa levels, the addition of bromocriptine caused a more stable response. Dose response curves to bromocriptine 12.5, 25, 50, and 100 mg and to levodopa 250, 500, 1000, and 2000 mg were studied in seven patients. Levodopa 2 g had a greater therapeutic effect and caused a greater rise in plasma growth hormone concentration than bromocriptine 100 mg. Levodopa caused emesis more commonly and hallucinations less commonly than bromocriptine. Bromocriptine appears to be a less potent stimulant than dopamine, and has both pre- and post-synaptic effects. Metoclopramide 60 mg oral was given 30 minutes before bromocriptine or levodopa to establish whether this caused dopamine-receptor blockade. Metoclopramide acted as a competitive antagonist to the anti-Parkinsonism and growth hormone effect of both drugs and in individual cases prevented emesis and hallucinations. The fall in blood pressure due to bromocriptine or levodopa was not antagonised by metoclopramide. Central and peripheral vascular dopamine receptors may be different in nature. (+info)

Bromocriptine • Cabergoline • Dihydroergocryptine • Lisuride • Lysergic acid diethylamide (LSD) • Pergolide Dihydrexidine ...

https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs

... causes arterial/arteriolar vasodilation leading to a decrease in blood pressure by activating peripheral D1 receptors.[5] It decreases afterload and also promotes sodium excretion via specific dopamine receptors along the nephron. The renal effect of fenoldopam and dopamine may involve physiological antagonism of the renin-angiotensin system in the kidney.[6] In contrast to dopamine, fenoldopam is a selective D1 receptor agonist with no effect on beta adrenoceptors, although there is evidence that it may have some alpha-1 [7] and alpha-2 adrenoceptor antagonist activity.[5] D1 receptor stimulation activates adenylyl cyclase and raises intracellular cyclic AMP, resulting in vasodilation of most arterial beds, including renal, mesenteric, and coronary arteries.[8] to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 minutes) and short duration of action (, 10 minutes) and a linear dose-response relationship at usual clinical doses.[9] ...

https://en.wikipedia.org/wiki/Fenoldopam

Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA- ... Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY- ... Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole) ... Unknown/unsorted: Ergolines (e.g., 2-Br-LSD (BOL-148), bromocriptine, lergotrile, pergolide) ...

https://en.wikipedia.org/wiki/Captodiame

The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...

https://en.wikipedia.org/wiki/Domperidone

Djaldetti Ruth; Giladi Nir; Hassin-Baer Sharon; Shabtai Hertzel; Melamed Eldad (November-December 2003). "Pharmacokinetics of Etilevodopa Compared to Levodopa in Patient's With Parkinson's Disease: An Open-label, Randomized, Crossover Study". Clinical Neuropharmacology. 26 (6): 322-326. doi:10.1097/00002826-200311000-00012. PMID 14646613 ...

https://en.wikipedia.org/wiki/Etilevodopa

Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (October 2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience. 24 (7): 2021-30. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298 ...

https://en.wikipedia.org/wiki/PD-168,077

The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In addition, we examined the evidence for publication bias. Forty-eight studies (total of 1,409 participants) were included in the analyses. We found evidence for small but significant stimulant enhancement effects on inhibitory control and short-term episodic memory. Small effects on working memory reached significance, based on one of our two analytical approaches. Effects on delayed episodic memory were medium in size. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of healthy cognition is probably modest overall. In some situations, a small advantage may be ...

https://en.wikipedia.org/wiki/Dopamine_receptor

... (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills.[1] It shares a similar chemical structure with α-PPP and MDPV,[2][3][4] and has been shown to have reinforcing effects in rats.[5] ...

https://en.wikipedia.org/wiki/MDPPP

... is a synthetic compound that acts as a selective antagonist on D2 dopamine receptors.[1] Its selectivity to the cerebral D2 receptors is characterized by its respective Ki-values, which are as follows: 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively. It can be radiolabelled with radioisotopes, e.g. 3H or 11C and used as a tracer for in vitro imaging (autoradiography) as well as in vivo imaging positron emission tomography (PET). Images obtained by cerebral PET scanning (e.g. PET/CT or PET/MRI) allow the non-invasive assessment of the binding capacity of the cerebral D2 dopamine receptor, which can be useful for the diagnosis of movement disorders. In particular, cerebral D2 receptor binding as measured by carbon-11-raclopride (11C-raclopride) has shown to reflect disease severity of Huntington's disease, a genetical disease characterized by selective degeneration of cerebral D2 receptors.[2] Other studies have investigated the relationship of D2 receptor ...

https://en.wikipedia.org/wiki/Raclopride

In 1960 the Austrian biochemist Oleh Hornykiewicz, while at the University of Vienna, examined results of autopsies of patients who had died with Parkinson's disease. He suggested that the disease was associated with, or caused by, a reduction in the levels of dopamine in the basal ganglia of the brain. Since dopamine itself did not enter the brain, he tried treating twenty patients with a racemic mixture of dihydroxyphenylalanine (DOPA), which could enter the brain and be converted there to dopamine by the action of DOPA decarboxylase. His results were positive, as were those of another trial in Montreal run by André Barbeau. Unfortunately, other investigators were unable to replicate these early results, and the use of DOPA remained in question until 1967, when George Cotzias at the Brookhaven National Laboratories in Upton, New York, used megadoses of DOPA, up to 16 grams per day. Not long after these results became known, Curt Porter at Merck showed that L-DOPA was the active stereoisomer, ...

https://en.wikipedia.org/wiki/Carbidopa/levodopa

Bromocriptine. *Cabergoline. *Lisuride. *Pergolide. *Terguride. References[edit]. *^ Antonella Di Sarno; Maria Luisa Landi; ...

https://en.wikipedia.org/wiki/Quinagolide

... crosses the protective blood-brain barrier, whereas dopamine itself cannot. Thus, L-DOPA is used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. This treatment was made practical and proven clinically by George Cotzias and his coworkers, for which they won the 1969 Lasker Prize.[4][5] Once L-DOPA has entered the central nervous system, it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor in this reaction, and may occasionally be administered along with L-DOPA, usually in the form of pyridoxine.. Besides the central nervous system, L-DOPA is also converted into dopamine from within the peripheral nervous system. Excessive peripheral dopamine signaling causes many of the adverse side effects seen with sole L-DOPA administration. To bypass these effects, it is standard clinical practice to coadminister (with ...

https://en.wikipedia.org/wiki/L-dopa

Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly. 66 (1): 87-95. doi:10.1007/ ...

https://en.wikipedia.org/wiki/Hypersexuality

The bioavailability of bromocriptine is increased; besides being an antiparkinsonian, bromocriptine is also used for the ... and bromocriptine mesylate at maximally tolerated doses severe diarrhea/flushing episodes associated with metastatic carcinoid ...

https://en.wikipedia.org/wiki/Octreotide

Bromocriptine may be used as well. Spironolactone, low dose oral contraceptives, and low-dose estrogen have helped to relieve ...

https://en.wikipedia.org/wiki/Breast_pain

Bromocriptine is an ergot derivative, semi-synthetic. Bromocriptine is a D2 receptor agonist and D1 receptor antagonist with a ... Bromocriptine reaches mean peak plasma levels in about 1-1.5 hours after a single oral dose. The drug has high protein binding ... Bromocriptine (Parlodel - used to treat PD/RLS) Cabergoline (Dostinex - used to treat PD/RLS) Ciladopa (used to treat PD/RLS) ... Bromocriptine has an ergot alkaloid structure. Ergot alkaloids are divided into 2 groups; amino acid ergot alkaloids and amine ...

https://en.wikipedia.org/wiki/Dopamine_agonist

Medications used include dantrolene, bromocriptine, and diazepam. The risk of death among those affected is about 10%. Rapid ... Dhib-Jalbut S, Hesselbrock R, Mouradian MM, Means ED (1987). "Bromocriptine treatment of neuroleptic malignant syndrome". The ... and more recently dopamine pathway medications such as bromocriptine have shown benefit.Amantadine is another treatment option ...

https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome

BROMOCRIPTINE MESYLATE 69. BUDESONIDE 70. BULAQUINE 71. BUPIVA CAINE HYDROCHLORIDE 72. BUPROPION ...

https://en.wikipedia.org/wiki/Schedule_H

A study by Goepel and Panhke provided indications that the inflammation should be controlled by bromocriptine even in absence ... Goepel and Pahnke and other authors[who?] recommend performing surgeries only with concomitant bromocriptine treatment. ...

https://en.wikipedia.org/wiki/Subareolar_abscess

Lang AE (August 1987). "Update on dopamine agonists in Parkinson's disease: "beyond bromocriptine"". The Canadian Journal of ...

https://en.wikipedia.org/wiki/Ciladopa

Medical therapy with cabergoline or bromocriptine generally suppresses prolactinomas; progesterone antagonist therapy has not ...

https://en.wikipedia.org/wiki/Adenoma

Arscott GD, Craig HR, Gabay L (2001). "Failure of bromocriptine therapy to control juvenile mammary hypertrophy". Br J Plast ... Treatment of hyperprolactinemia-associated macromastia with D2 receptor agonists such as bromocriptine and cabergoline has been ... Medical regimens have included tamoxifen, progesterone, bromocriptine, the gonadotropin-releasing hormone agonist leuprorelin, ...

https://en.wikipedia.org/wiki/Breast_hypertrophy

Bromocriptine is a dopamine agonist that helps lower blood pressure. Its effects are modest, but they are not well understood. ...

https://en.wikipedia.org/wiki/Paroxysmal_sympathetic_hyperactivity

Clarke CE, Speller JM (2000). "Lisuride versus bromocriptine for levodopa-induced complications in Parkinson's disease". ... to support lisuride in the treatment of advanced Parkinson's disease as an alternative to levodopa or bromocriptine. Side ...

https://en.wikipedia.org/wiki/Lisuride

Bromocriptine - full agonist Cabergoline (Dostinex) N,N-Propyldihydrexidine - analogue of the D1/D5 agonist dihydrexidine; ... Cameron IG, Wallace DL, Al-Zughoul A, Kayser AS, D'Esposito M (April 2018). "Effects of tolcapone and bromocriptine on ... In similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly ...

https://en.wikipedia.org/wiki/Dopamine_receptor_D2

Attempts to moderate dyskinesia by the use of other treatments such as bromocriptine (Parlodel), a dopamine agonist, appears to ... van Hilten J; Ramaker C; Stowe R; Nj Ives (2007). "Bromocriptine/levodopa combined versus levodopa alone for early Parkinson's ...

https://en.wikipedia.org/wiki/Levodopa-induced_dyskinesia

Bromocriptine acts in a completely different manner to the other treatments mentioned above. It does not induce ovulation, but ... Bromocriptine is only prescribed in cases of overproduction of prolactin (hyperprolactinemia). Corticosteroids (usually found ...

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Bromocriptine lowers GH and IGF-1 levels and reduces tumor size in fewer than half of people with acromegaly. Some people ... The current first choice is generally octreotide or lanreotide; however, bromocriptine and cabergoline are both cheaper and ... bromocriptine or cabergoline. As tablets rather than injections, they cost considerably less. These drugs can also be used as ...

https://en.wikipedia.org/wiki/Acromegaly

Colao A, Di Sarno A, Guerra E, De Leo M, Mentone A, Lombardi G (April 2006). "Drug insight: Cabergoline and bromocriptine in ... Kilicdag EB, Tarim E, Bagis T, Erkanli S, Aslan E, Ozsahin K, Kuscu E (June 2004). "Fructus agni casti and bromocriptine for ... Treatment is usually medication with dopamine agonists such as cabergoline and bromocriptine (often preferred when pregnancy is ... "A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study ...

https://en.wikipedia.org/wiki/Hyperprolactinaemia

Another treatment option is bromocriptine, which directly stimulates D2 Dopamine Receptors. Bromocriptine is less effective ...

https://en.wikipedia.org/wiki/Clinical_neurochemistry

Bromocriptine, Bromocriptine mesilate, Bromocriptine mesylate, Bromocriptine methanesulfonate, Bromocriptini mesilas, ... "Bromocriptine mesylate tablet label" (PDF). FDA. February 2017. Archived (PDF) from the original on 2018-05-13.. . For label ... "Bromocriptine mesylate tablets -- original uses" (PDF). FDA. January 2012. Archived (PDF) from the original on 2017-02-28.. For ... Bromocriptine (originally marketed as Parlodel, subsequently under many names)[1] is an ergoline derivative, is a dopamine ...

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Bromocriptine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Bromocriptine (Parlodel) comes as a capsule and a tablet to take by mouth. Bromocriptine (Cycloset) comes as a tablet to take ... Bromocriptine (Cycloset) is usually taken once a day with food within 2 hours of waking in the morning. Take bromocriptine at ... Before taking bromocriptine,. *tell your doctor and pharmacist if you are allergic to bromocriptine; ergot alkaloids such as ...

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A list of US medications equivalent to Bromocriptine is available on the Drugs.com website. ... Bromocriptine is a medicine available in a number of countries worldwide. ... Bromocriptine Zentiva. Sanofi-Aventis, France. *Bromocriptine-Richter. Gedeon Richter, Bangladesh; Gedeon Richter, Malaysia; ... In the US, Bromocriptine (bromocriptine systemic) is a member of the following drug classes: dopaminergic antiparkinsonism ...

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Bromocriptine definition, an ergot derivative, C 32 H 40 BrN 5 O 5 , that inhibits prolactin and growth hormone secretions and ... bromocriptine in Medicine Expand. bromocriptine bro·mo·crip·tine (brōmō-krĭptēn). n. An ergot alkaloid that slows dopamine ...

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Bromocriptine for idiopathic oligo/asthenospermia.. Vandekerckhove P1, Lilford R, Vail A, Hughes E. ... Bromocriptine appears to reduce prolactin levels in subfertile men with normal gonadotrophic function. There is not enough ... Whilst bromocriptine treatment for reducing prolactin levels in hyperprolactinaemic males (as in females), and, in the ... Compared with placebo, bromocriptine was associated with a significant reduction in serum prolactin levels (weighted mean ...

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... bromocriptine, edema - Answer: Swelling in your ankles or feet is a serious side effect of bromocriptine. ... ... Home › Q & A › Questions › Bromocriptine - Does it cause.... Bromocriptine - Does it cause edema?. Asked. 17 Sep 2009 by ... Side Effects of Bromocriptine (detailed). Search for questions. Still looking for answers? Try searching for what you seek or ... Did anyone try bromocriptine deratives it gave me vomitings. can anyone guide me with the dosages p?. Posted 22 Nov 2010 • 1 ...

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Bromocriptine belongs to the group of medicines known as ergot alkaloids. Bromocriptine blocks the release of a hormone called ... Information about this bromocriptine-oral-route. Pregnancy Category. Explanation. All Trimesters. B. Animal studies have ... Bromocriptine is also used together with a proper diet and exercise to treat high blood sugar levels in patients with type 2 ... Bromocriptine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth ...

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Bromocriptine oral tablet is a prescription drug. Its generic form and its brand-name version Parlodel are used to treat ... What is bromocriptine?. Bromocriptine is a prescription drug. It comes in the form of a tablet and a capsule you take by mouth. ... Highlights for bromocriptine. *Bromocriptine oral tablet is available as a generic drug and as brand-name drugs. Brand names: ... Bromocriptine side effects. Bromocriptine oral tablet can cause dizziness and drowsiness during the first few hours after you ...

https://www.healthline.com/health/bromocriptine-oral-tablet

Parlodel is another brand of bromocriptine that is not covered in this medication guide. The Cycloset brand of bromocriptine is ... This medication guide provides information about the Cycloset brand of bromocriptine. ... What is bromocriptine (Cycloset)?. What is bromocriptine (Cycloset)?. This medication guide provides information about the ... Bromocriptine lowers the hormone needed to produce breast milk. Do not breast-feed a baby while taking bromocriptine. ...

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WebMD provides information about interactions between Clarithromycin Oral and selected-macrolide-antibiotics-bromocriptine- ... Your doctor may not want you to take bromocriptine or cabergoline while you are taking your antifungal.If you experience nausea ... Bromocriptine; Cabergoline/Selected Macrolide Antibiotics Interactions. This information is generalized and not intended as ... 2.Cycloset (bromocriptine mesylate) tablets, US prescribing information. Veroscience LLC February 2, 2016. ...

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Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...

https://echa.europa.eu/substance-information/-/substanceinfo/100.042.829

Bromocriptine is taken in the morning. Drug: Bromocriptine Investigating the randomized order for timing of bromocriptine ... Bromocriptine is taken in te evening. Drug: Bromocriptine Investigating the randomized order for timing of bromocriptine ... Bromocriptine and Insulin Sensitivity (BIS). The safety and scientific validity of this study is the responsibility of the ... Bromocriptine, a dopamine 2 receptor agonist, has recently been approved in the treatment of type 2 diabetes mellitus(DM2). ...

https://www.clinicaltrials.gov/ct2/show/NCT02428946

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Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinoma because of its long ... Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinoma because of its long ... encoded search term (What is the role of bromocriptine (BEC) in the treatment of prolactinomas?) and What is the role of ... What is the role of bromocriptine (BEC) in the treatment of prolactinomas?. Updated: Mar 25, 2018 ...

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For best results, bromocriptine should be taken with food or milk. Storage. Store in a dry place away from heat and direct ... Bromocriptine reduces the bodys tolerance to alcohol. Pregnancy. If you are pregnant or plan to become pregnant, tell your ... In some cases bromocriptine may be used to treat acromegaly (overproduction of growth hormone, causing enlargement of the hands ... Bromocriptine blocks the pituitary from releasing the hormone prolactin, which is involved in the regulation of the menstrual ...

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Effects of cocaine alone and with bromocriptine - Effects of cocaine alone and in combination with bromocriptine in human ... Bromocriptine (Parlodel, Cycloset), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary ... In 2009, bromocriptine mesylate was approved by the FDA for treatment of type 2 diabetes under the trade name Cycloset ( ... Bromocriptine use has been associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most ...

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I found out almost 4 weeks ago that my Prolactin level is 25, had an MRI done and started Bromocriptine at that time. Befor... ... I never took Bromocriptine my endo doctor just waited to see if my levels would go down and they havent Ive been trying for ... I found out almost 4 weeks ago that my Prolactin level is 25, had an MRI done and started Bromocriptine at that time. Before ... I guess what Im wondering is since my cycles were pretty normal already will the Bromocriptine be enough to get me pregnant? I ...

http://www.medhelp.org/posts/Fertility---Infertility/High-Prolactin-Levels--Bromocriptine--and-a-normal-menstrual-cycle/show/1409546

Cycloset is another brand of bromocriptine that is not covered in this medication guide. The Parlodel brand of bromocriptine is ... This medication guide provides information about the Parlodel brand of bromocriptine. ... What is bromocriptine (Parlodel)?. This medication guide provides information about the Parlodel brand of bromocriptine. ... You should not use this medication if you are allergic to bromocriptine or to an ergot medicine (Ergomar, Cafergot, Migergot, D ...

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Recently, bromocriptine is used in treatment of diabetes mellitus type II to improve insulin resistance. Objective: The aim of ... Case group was given bromocriptine 2.5 mg daily and placebo was given to control group. Patients were treated for 8 days and in ... bromocriptine reduced FBS and insulin levels and insulin resistance in PCO patients with pre-diabetes range. ... this study is the evaluation of bromocriptine on insulin resistance in PCO people. Patients and Methods: In this single-blind ...

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Bromocriptine belongs to a group of medications called ergot alkaloids. It is used to treat Parkinsons disease and conditions ... Breast-feeding: Bromocriptine reduces the production of breast milk. The use of bromocriptine after childbirth is more likely ... Bromocriptine belongs to a group of medications called ergot alkaloids. It is used to treat Parkinsons disease and conditions ... Pregnancy: Bromocriptine may be taken by women who are pregnant if the benefits outweigh the risks. If you become pregnant ...

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... Neuroreport. 1997 Nov 10;8(16):3581-5. doi: ... We hypothesized that bromocriptine would have an effect on cognitive functions associated with the prefrontal cortex via its ... We found that the effect of bromocriptine on young normal subjects depended on the subjects working memory capacity. High- ... We hypothesized that bromocriptine would have a … ...

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... bromocriptine (Cycloset)) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, ... Generic Name: bromocriptine (Cycloset). *What is bromocriptine (Cycloset) (Cycloset)?. *What are the possible side effects of ... Bromocriptine lowers the hormone needed to produce breast milk. Do not breast-feed a baby while taking bromocriptine. ... You should not use this medication if you are allergic to bromocriptine or to an ergot medicine (Ergomar, Cafergot, Migergot, D ...

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What is bromocriptine mesylate? Meaning of bromocriptine mesylate medical term. What does bromocriptine mesylate mean? ... Looking for online definition of bromocriptine mesylate in the Medical Dictionary? bromocriptine mesylate explanation free. ... bromocriptine mesylate. Apo-Bromocriptine (CA), Cycloset, Dom-Bromocriptine (CA),Parlodel, PMS-Bromocriptine (CA) ... bromocriptine mesylate. Also found in: Dictionary, Encyclopedia.. Related to bromocriptine mesylate: hyperprolactinemia, ...

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If Bromocriptine was eventually administered to suppress lactation but afterwards the mother is willing to resuming ... Nor side effects occurred on 14 infants whose mothers received 2.5 mg of bromocriptine from 5th to 8th day after birth to treat ... 30 cases of galactorrhea-prolactinoma-hyperprolactinemia that were treated with a daily dose of 2.5 to 5 mg of Bromocriptine ... Is cabergoline an alternative to bromocriptine? Prescrire Int. 2015 Abstract *Serrano Aguayo P, García de Quirós Muñoz JM, ...

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Cabergoline versus bromocriptine for levodopa-induced complications in Parkinsons disease. Download Prime PubMed App to iPhone ... Pramipexole versus bromocriptine for levodopa-induced complications in Parkinsons disease.. *Ropinirole versus bromocriptine ... Antiparkinson AgentsBromocriptineCabergolineDopamine AgonistsDyskinesia, Drug-InducedErgolinesHumansLevodopaParkinson Disease ... Cabergoline versus bromocriptine for levodopa-induced complications in Parkinsons disease.. Cochrane Database Syst Rev. 2001CD ...

https://www.unboundmedicine.com/medline/citation/11279721/Cabergoline_versus_bromocriptine_for_levodopa_induced_complications_in_Parkinson

2.Cycloset (bromocriptine mesylate) tablets, US prescribing information. (webmd.com)
In 2009, bromocriptine mesylate was approved by the FDA for treatment of type 2 diabetes under the trade name Cycloset (VeroScience). (thefullwiki.org)
Bromocriptine (as mesylate) 5mg. (oncologynurseadvisor.com)
Bromocriptine Mesylate is prescribed for the treatment of Parkinson's disease and people who have too much growth hormone. (healthyhub.biz)
Above there is a review of a few trusted and qualitative online drugstores and pharmacies where you can buy bromocriptine or order cheap Parlodel (Bromocriptine Mesylate) online, get discount coupon, compare prices for antiparkinsonian drugs, medications for women's health, prolactine inhibitors, dopamine receptor agonists, and many other medicines at a low prices to choose the most acceptable offer for you. (healthyhub.biz)
Background: Bromocriptine-QR (a quick-release formulation of bromocriptine mesylate), a dopamine D2 receptor agonist, is a US Food and Drug Administrration-approved treatment for type 2 diabetes mellitus (T2DM). (harvard.edu)
The generic ingredient in CYCLOSET is bromocriptine mesylate . (drugpatentwatch.com)
Additional details are available on the bromocriptine mesylate profile page. (drugpatentwatch.com)
The long-acting dopamine agonist bromocriptine mesylate as additive immunosuppressive drug after kidney transplantation. (chemeurope.com)
More than a year after the U.S. Food and Drug Administration approved Cycloset (bromocriptine mesylate) for treatment of type 2 diabetes, it's now available at pharmacies. (diabeticmediterraneandiet.com)
Cycloset (generic name = bromocriptine mesylate) was just approved for treatment of type 2 diabetes by the U.S. Food and Drug Administration. (diabeticmediterraneandiet.com)
Why is Bromocriptine mesylate prescribed? (drugster.info)
How should you take Bromocriptine mesylate? (drugster.info)
Why should Bromocriptine mesylate not be prescribed? (drugster.info)
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. (drugbank.com)

Bromocriptine (Cycloset) is used with a diet and exercise program and sometimes with other medications to control blood sugar levels in people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). (medlineplus.gov)
Bromocriptine (Cycloset) is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). (medlineplus.gov)
Bromocriptine (Cycloset) is usually taken once a day with food within 2 hours of waking in the morning. (medlineplus.gov)
If you are taking bromocriptine (Cycloset) for diabetes, ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. (medlineplus.gov)
Bromocriptine oral tablet is available as the brand-name drugs Parlodel and Cycloset. (healthline.com)
This medication guide provides information about the Cycloset brand of bromocriptine. (cigna.com)
What is bromocriptine (Cycloset)? (cigna.com)
The Cycloset brand of bromocriptine is used together with diet and exercise to treat type 2 diabetes. (cigna.com)
Bromocriptine ( Parlodel , Cycloset ), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors , Parkinson's disease (PD), neuroleptic malignant syndrome , and type 2 diabetes . (thefullwiki.org)
The Cycloset Safety Trial was designed to assess the overall safety and specifically address cardiovascular safety for a novel treatment for type 2 diabetes, quick-release bromocriptine (bromocriptine-QR) ( 11 ). (diabetesjournals.org)
Update December 3, 2010: Cycloset is not the same formulation of bromocriptine used to treat other diseases. (diabeticmediterraneandiet.com)
Although the parent compound in Cycloset is bromocriptine the formulation is uniquely different from traditional formulations of bromocriptine. (diabeticmediterraneandiet.com)
A close inspection of the package insert of Cycloset vs. traditional formulations reveals one significant difference in that the absorption efficiency of Cycloset is 2-3 times greater than traditional formulations of bromocriptine. (diabeticmediterraneandiet.com)
QR-bromocriptine (Cycloset™) has recently been approved in the USA for the treatment of type 2 diabetes mellitus (T2DM). (diabeticmediterraneandiet.com)

This review considers the available evidence of the effect of bromocriptine therapy for normoprolactinaemic males with idiopathic oligo and/or asthenospermia. (nih.gov)
Swelling in your ankles or feet is a serious side effect of bromocriptine. (drugs.com)
The investigators did found an effect of bromocriptine on insulin sensitivity unexpectedly, subjects became significantly less insulin sensitive after bromocriptine use. (clinicaltrials.gov)
Also, the effect of bromocriptine might be different in lean or obese subjects. (clinicaltrials.gov)
We found that the effect of bromocriptine on young normal subjects depended on the subjects' working memory capacity. (nih.gov)
Using increasing doses of bromocriptine in estrogen-treated rats, we bromocriptune recently reported that the effect of bromocriptine in reducing the number of immunoreactive lactotrophs was observed only after long-term estrogen treatment including bromocriptine administration for 12 days When I woke up I very slowly made my way out of bed to the bathroom, taking care to not pass out hypotension being another common side. (terra-media.us)
The primary endpoint is the effect of Bromocriptine QR on changes in autonomic function measured by assessing sympathetic and parasympathetic function using conventional measures of autonomic function, including power spectral analysis of heart rate as well as peripheral autonomic function using sudorimetry and laser scanning of peripheral microvascular autonomic control. (clinicaltrials.gov)
To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including non-prescription medication, OTCs, health supplements like vitamins, minerals, herbal medicine, drinks with caffeine and alcohol, illegal drugs, smoking habits and so on which may increase or interfere with the effect of Bromocriptine. (internationaldrugmart.com)
Therefore, it is the thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the brain and plasma amino acid concentrations of rat. (thescipub.com)

Consult your doctor for specific advice if you are taking any of the following drugs that may interact with bromocriptine: blood pressure medication, an oral contraceptive, erythromycin, a phenothiazine, an MAO inhibitor, progestin, levodopa, or a rauwolfia alkaloid. (wholehealthmd.com)
Bromocriptine may be used alone or with levodopa to reduce symptoms of Parkinson's disease. (medbroadcast.com)
To compare the efficacy and safety of adjuvant cabergoline therapy versus bromocriptine in patients with Parkinson's disease, already established on levodopa and suffering from motor complications. (unboundmedicine.com)
Randomised controlled trials of cabergoline versus bromocriptine in patients with a clinical diagnosis of idiopathic Parkinson's disease and long-term complications of levodopa therapy. (unboundmedicine.com)
Levodopa dose reduction was no different between cabergoline and bromocriptine. (unboundmedicine.com)
Cabergoline produces similar benefits to bromocriptine in off time reduction, motor impairment and disability ratings, and levodopa dose reduction over the first three months of therapy. (unboundmedicine.com)
TY - JOUR T1 - Cabergoline versus bromocriptine for levodopa-induced complications in Parkinson's disease. (unboundmedicine.com)
Patients unresponsive to levodopa: poor candidates for bromocriptine therapy. (oncologynurseadvisor.com)
A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson's disease: a five year follow up. (bmj.com)
Bromocriptine versus levodopa in early Parkinson's disease. (acpjc.org)
In patients with Parkinson disease (PD), how effective is bromocriptine (BR) monotherapy for delaying the onset of motor complications associated with levodopa (LD) therapy? (acpjc.org)
In patients with Parkinson disease who can tolerate bromocriptine, bromocriptine may be beneficial in delaying motor complications and dyskinesias with effects similar to levodopa therapy on impairment and disability. (acpjc.org)
Six patients remained on bromocriptine monotherapy for 10 years, while 22 patients achieved good disease control with bromocriptine plus levodopa (added during the course of the study). (curehunter.com)
Thus, early introduction and long continuation of bromocriptine therapy with restricted concomitant use of levodopa may have led to very slow disease progression and the suppression of adverse reactions. (curehunter.com)
Although the patients who could be maintained long-term on bromocriptine monotherapy might represent a population who have very slowly progressive disease, their adequate disease control and the low incidence of adverse reactions in the patients who later started concomitant levodopa suggest that the unwanted effects of levodopa may be reduced by early and sustained treatment with bromocriptine . (curehunter.com)
Introduction of bromocriptine monotherapy at an early stage of Parkinson's disease or with restricted use of additional levodopa therapy to bromocriptine when necessary may be a useful strategy for achieving adequate and sustained disease control. (curehunter.com)
Early studies suggested that treating patients with bromocriptine before levodopa would delay the onset of side effects such as dyskinesia. (chemeurope.com)
Good results have been reported in patients with end-of-dose deterioration and levodopa-induced dyskinesias, and recent studies suggest a beneficial effect from early treatment with a combination of levodopa and bromocriptine. (depressionofspirits.com)

Bromocriptine lowers levels of growth hormone in the body. (healthline.com)
Bromocriptine lowers the hormone needed to produce breast milk. (emedicinehealth.com)
Bromocriptine lowers the prolactin levels to normal (in most labs, the normal range is less than 20 ng/ml). (drmalpani.com)
This is paradoxical, since in people suffering from acromegaly, or growth hormone excess, bromocriptine has the opposite effect: it actually lowers GH levels. (mindandmuscle.net)
Bromocriptine lowers prolactin levels to normal (the normal range in most laboratories being less than 20 ng/ml) and allows the ovary to get back to normal. (drmalpani.com)
bromocriptine Very often, bromocriptine lowers PRL levels despite continued tumor expansion, though when tumors develop throughout dopamine agonist therapy there's often a simultaneous PRL elevation. (climb-asia.com)
Phase II and III clinical studies show that QR-bromocriptine lowers glycated haemoglobin by 0.6-1.2% (7-13 mmol/mol) either as monotherapy or in combination with other antidiabetes medications. (diabeticmediterraneandiet.com)

When bromocriptine (Parlodel) is used to treat acromegaly, it is usually taken once a day at bedtime with food. (medlineplus.gov)
Bromocriptine is also used to treat acromegaly (overproduction of growth hormone) and pituitary prolactinomas (tumors of the pituitary gland). (mayoclinic.org)
Appropriate studies have not been performed on the relationship of age to the effects of bromocriptine to treat acromegaly, Parkinson's disease, and type 2 diabetes in the pediatric population. (mayoclinic.org)
In some cases bromocriptine may be used to treat acromegaly (overproduction of growth hormone, causing enlargement of the hands, feet, jawbone, and internal organs). (wholehealthmd.com)
Bromocriptine is used to treat acromegaly (overproduction of growth hormone causing unusual enlargement of the hands, jaw, and feet) by decreasing the production of growth hormone. (medbroadcast.com)
This work reports the clinical, hormonal and radiological effects of a single 50 mg dose of long-acting bromocriptine in 10 patients with tumorous hyperprolactinemia (2 microprolactinomas, 6 macroprolactinomas, 1 acromegaly and 1 nonsecreting macroadenoma). (springer.com)
Grossman A., Ross R., Wass J.A.H., Besser G.M. Depot-bromocriptine treatment for prolactinomas and acromegaly. (springer.com)
BROMOCRIPTINE will successfully lower prolactin ranges in patients with pituitary tumours but doesn't obviate the necessity for radiotherapy or surgical intervention where appropriate in acromegaly. (climb-asia.com)
Bromocriptine is sometimes used together with surgery or radiation in treating acromegaly, a condition caused by a pituitary gland tumor that produces too much growth hormone. (pharmacy-network.com)
I assume it's the same bromocriptine that's been available for years to treat Parkinson's disease and acromegaly. (diabeticmediterraneandiet.com)
Bromocriptine is an approved drug originally indicated for Parkinson's disease, acromegaly, hyperprolactinemia and galactorrhoea, and recently repositioned for diabetes mellitus. (biomedcentral.com)
By means of an in silico screening searching for approved small bioactive drugs that potentially induce differentiation of AML cells, bromocriptine, a drug originally indicated for Parkinson's disease, acromegaly, hyperprolactinemia and galactorrhoea, and recently repositioned for diabetes mellitus [ 7 , 8 ], was identified. (biomedcentral.com)

or any of the ingredients in bromocriptine tablets or capsules. (medlineplus.gov)
During these first 4 weeks, the daily dose of the study drug will be titrated up by one tablet (0.8 mg bromocriptine- QR) per day on a weekly basis until a maximal tolerated dose of at least two tablets (1.6 mg/day bromocriptine- QR) and no more than four tablets (3.2 mg/per day b-QR) is achieved. (clinicaltrials.gov)
Pramipexole tablets or Bromocriptine tablets. (clinicaltrials.gov)
A Randomized Single-blind Placebo Controlled Comparative Trial of Pramipexole Tablets and Bromocriptine Tablets in Patients With Parkinson's Disease. (clinicaltrials.gov)
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Bromocriptine (Parlodel) is used to treat symptoms of hyperprolactinemia (high levels of a natural substance called prolactin in the body) including lack of menstrual periods, discharge from the nipples, infertility (difficulty becoming pregnant) and hypogonadism (low levels of certain natural substances needed for normal development and sexual function). (medlineplus.gov)
Bromocriptine (Parlodel) may be used to treat hyperprolactinemia caused by certain types of tumors that produce prolactin, and may shrink these tumors. (medlineplus.gov)
When bromocriptine (Parlodel) is used to treat hyperprolactinemia, it is usually taken once a day with food. (medlineplus.gov)
The Parlodel brand of bromocriptine is used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia). (wellspan.org)
A successful breastfeeding has been described on about 30 cases of galactorrhea-prolactinoma-hyperprolactinemia that were treated with a daily dose of 2.5 to 5 mg of Bromocriptine with no effects noticed on the infants (Canales 1981, Cheng 1996, Verma 2006). (e-lactancia.org)
Bromocriptine is a drug that's used to treat women with hyperprolactinemia. (drmalpani.com)
Several dopamine agonists are currently available for the treatment of hyperprolactinemia, including bromocriptine and cabergoline in the USA and, additionally, quinagolide in the UK and most other European countries (2,4). (biomedsearch.com)
Bromocriptine is used for the treatment of disorders associated with hyperprolactinemia, including amenorrhea (lack of menstruation), with or without galactorrhea (a secretion of milk from the breast that is not associated with breastfeeding), infertility or hypogonadism. (myfertility.ca)
Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. (drugbank.com)
you are taking Bromocriptine only for hyperprolactinemia and become pregnant. (ampills.com)

Bromocriptine (originally marketed as Parlodel , subsequently under many names) [1] is an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors , Parkinson's disease (PD), hyperprolactinaemia , neuroleptic malignant syndrome , and type 2 diabetes . (wikipedia.org)
A quick-release formulation of bromocriptine is also used to treat type 2 diabetes . (wikipedia.org)
The way bromocriptine works to treat diabetes is not known. (medlineplus.gov)
Bromocriptine is also used together with a proper diet and exercise to treat high blood sugar levels in patients with type 2 diabetes. (mayoclinic.org)
Bromocriptine, a dopamine 2 receptor agonist, has recently been approved in the treatment of type 2 diabetes mellitus(DM2). (clinicaltrials.gov)
Recently, bromocriptine is used in treatment of diabetes mellitus type II to improve insulin resistance. (scirp.org)
Conclusion: Our study showed, even in the short-term consumption, bromocriptine reduced FBS and insulin levels and insulin resistance in PCO patients with pre-diabetes range. (scirp.org)
Defronzo, R.A. (2011) Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes. (scirp.org)
BROMOCRIPTINE (broe moe KRIP teen) is used to treat type 2 diabetes. (ahealthyme.com)
Bromocriptine has been indicated in the treatment of Type II diabetes, due to its ability to suppress lipogenesis and improve glucose tolerance and insulin resistance. (antiaging-systems.com)
How effective is bromocriptine for the treatment of diabetes? (sharecare.com)
Bromocriptine has been reported to reduce A1C by 0.6% to 0.7% when taken alone or with other oral diabetes drugs. (sharecare.com)
This is an interventional, twenty-four week, randomized, double blind, placebo-controlled trial with bromocriptine QR in subjects with newly diagnosed and established type 2 diabetes mellitus (T2DM) to evaluate its effects on the cardiovascular and peripheral autonomic nervous system, as well as on inflammatory markers, the leptin/adiponectin system, hormonal levels of RAS and HPA axis, indices of insulin resistance, and measures of oxidative and nitrosative stress. (clinicaltrials.gov)
Forty newly diagnosed diabetes subjects and 40 subjects with established diabetes will be enrolled in the study and each randomized to treatment with bromocriptine-QR or placebo. (clinicaltrials.gov)
Secondary endpoints will demonstrate the effects of dopaminergic activation with Bromocriptine-QR on the regulation of Hypothalamic-Pituitary-Axis (HPA) axis hormones, on the plasma levels of markers of inflammation and oxidative/nitrosative stress in newly diagnosed vs. established type 2 diabetes subjects. (clinicaltrials.gov)
Subjects will be randomized in a 1:1 ratio to receive UDT (usual diabetes therapy) plus bromocriptine- QR. (clinicaltrials.gov)
OBJECTIVE Quick-release bromocriptine (bromocriptine-QR), a D2 dopamine receptor agonist, is indicated as a treatment for type 2 diabetes. (diabetesjournals.org)
RESEARCH DESIGN AND METHODS A total of 3,095 patients with type 2 diabetes were randomized 2:1 to bromocriptine-QR or placebo in conjunction with the patient's usual diabetes therapy (diet controlled only or up to two antidiabetes medications, including insulin). (diabetesjournals.org)
Although bromocriptine-QR had demonstrated improvements in various metabolic parameters in patients with type 2 diabetes as well as improvements in many surrogate markers of cardiovascular disease, ( 16 , 17 ) data from these previous clinical studies were insufficiently powered to adequately assess cardiovascular safety. (diabetesjournals.org)
Conclusions: These findings reaffirm and extend the original observation of relative risk reduction in cardiovascular adverse events among type 2 diabetes subjects treated with bromocriptine-QR and suggest that further investigation into this impact of bromocriptine-QR is warranted. (harvard.edu)
The concurrent use of a postprandial insulin sensitizing agent, such as bromocriptine-QR, a quick release formulation of bromocriptine, a dopamine D2 receptor agonist, may offer a strategy to improve glycemic control and limit/reduce insulin requirement in type 2 diabetes (T2DM) patients on high-dose insulin. (harvard.edu)
A company called Veroscience [4] is using bromocriptine to treat diabetes and obesity, and their website postulates a connection between neurotransmitters and seasonal variation in insulin sensitivity among vetebrate animals. (chemeurope.com)
Bromocriptine improves glycaemic control and serum lipid profile in obese Type 2 diabetic subjects: a new approach in the treatment of diabetes. (chemeurope.com)
This quick-release formulation is the only bromocriptine product indicated for type 2 diabetes mellitus. (medscape.com)

Bromocriptine blocks the release of a hormone called prolactin from the pituitary gland. (mayoclinic.org)
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of bromocriptine in teenagers 16 years of age and older with prolactin-secreting pituitary adenomas. (mayoclinic.org)
Bromocriptine blocks the pituitary from releasing the hormone prolactin, which is involved in the regulation of the menstrual cycle, reproduction, and milk production. (wholehealthmd.com)
For conditions associated with too much prolactin, bromocriptine works by blocking the release of prolactin from the pituitary gland in the brain. (medbroadcast.com)
Apr 1;53(7) Comparative effects of tamoxifen and bromocriptine on prolactin and pituitary weight in estradiol-treated male rats. (terra-media.us)
The general antiprolactinemic and antiproliferative pituitary effects of bromocriptine treatment reported here validate this model of estrogen-induced hyperprolactinemic rats. (terra-media.us)
Six men with prolactin-secreting pituitary macroadenomas and deficiencies of pituitary hormones other than gonadotrophins were treated with bromocriptine for 6 months. (annals.org)
We conclude that pituitary hormonal functions may improve during bromocriptine treatment for prolactin-secreting pituitary macroadenomas. (annals.org)
This improvement may result from decompression of other pituitary cells, because correction of hypothyroidism by bromocriptine was accompanied by conversion from an absent to a normal thyrotrophin response to thyrotrophin-releasing hormone. (annals.org)
bromocriptine Hyperprolactinaemia could also be idiopathic, drug-induced, or due to hypothalamic or pituitary disease. (climb-asia.com)
The possibility that hyperprolactinaemic sufferers may have a pituitary tumour ought to be recognised and full investigation at specialised items bromocriptine to establish such sufferers is advisable. (climb-asia.com)
Rapid deterioration of visual fields during bromocriptine-induced pregnancy in a patient with a pituitary adenoma. (bmj.com)
Bromocriptine (brand names include Parlodel), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors and Parkinson's disease. (chemeurope.com)
Bromocriptine also reduces your levels of prolactin, a hormone that is released from the pituitary gland. (pharmacy-network.com)
Bromocriptine mimics the neurotransmitters in a woman's body that inhibit prolactin secretion in her pituitary. (myfertility.ca)

Parlodel is another brand of bromocriptine that is not covered in this medication guide. (cigna.com)
Bromocriptine may also be used for purposes not listed in this medication guide. (cigna.com)
You should not use this medication if you are allergic to bromocriptine or to an ergot medicine (Ergomar, Cafergot, Migergot, D.H.E. 45, Migranal, Methergine). (cigna.com)
After starting bromocriptine, prolactin levels can be tested after at least one week of medication. (drmalpani.com)
Bromocriptine is a medication prescribed for a wide range of ailments such as Parkinson's disease, menstrual problems, infertility and abnormal milk production in men or women. (internationaldrugmart.com)
After starting bromocriptine, prolactin levels can be tested (after at least one week of medication) to confirm that they have been brought down to normal. (drmalpani.com)
You should not use this medication if you are allergic to bromocriptine, or if you have uncontrolled high blood pressure (hypertension), hypertension caused by pregnancy, including eclampsia and preeclampsia, or if you are allergic to any type of ergot medicine such as Ergomar, D.H.E. 45, Migranal Nasal Spray Ergotrate, or Methergine. (pharmacy-network.com)
Hypoglycemia is not much of a problem, if any, when bromocriptine is used as the sole diabetic medication. (diabeticmediterraneandiet.com)
Bromocriptine is an ergot medication that works by helping to restore the balance of a certain natural substance (dopamine) in the brain. (healthpluspharmacy.com)

Bromocriptine may contain lactose. (cigna.com)
Parlodel (Bromocriptine) may also contain lactose so it is important to inform your physician if you have some metabolic problems with lactose such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption. (medformula.com)

Take bromocriptine at around the same time(s) every day. (medlineplus.gov)
Take bromocriptine exactly as directed. (medlineplus.gov)
Your doctor may not want you to take bromocriptine or cabergoline while you are taking your antifungal.If you experience nausea, constipation, loss of appetite, dry mouth, vomiting, abnormal involuntary movements, headache, dizziness, weakness, or fatigue contact your healthcare professional.Your healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. (webmd.com)
It's best to take bromocriptine with meals. (drmalpani.com)
Take bromocriptine with food, even if you take it at bedtime. (pharmacy-network.com)

The objective of this review was to assess the effects of bromocriptine on pregnancy rates among couples where subfertility has been attributed to idiopathic oligo- and/or asthenospermia. (nih.gov)
There was also no effect on pregnancy rates observed between bromocriptine and placebo (0.70 odds ratio, 95% confidence interval 0.15 to 3.24). (nih.gov)
FDA pregnancy category B. Bromocriptine is not expected to harm an unborn baby. (cigna.com)
High blood pressure can also occur during pregnancy and bromocriptine could be dangerous if taken by a pregnant woman with high blood pressure. (cigna.com)
Background & objectives: The aim of this study was to compare the effects of bromocriptine versus cabergoline on pregnancy in hyperprolactinaemic infertile women. (biomedsearch.com)

Bromocriptine has also been used off-label to treat restless legs syndrome and neuroleptic malignant syndrome. (drugbank.com)

[11] Pulmonary fibrosis has been reported when bromocriptine was used in high doses for the treatment of Parkinson's disease. (wikipedia.org)
The generic form of bromocriptine oral tablet and its brand-name version Parlodel are used to treat symptoms of Parkinson's disease. (healthline.com)
For Parkinson's disease, bromocriptine works by behaving like dopamine, a chemical in the brain, which is involved in producing the symptoms of this disease. (medbroadcast.com)
Only one randomised cross-over trial including 20 patients has compared lisuride with bromocriptine as adjunct therapy in Parkinson's disease. (unboundmedicine.com)
The small size of this study and other methodological problems do not allow any firm conclusions to be drawn regarding the efficacy and safety of lisuride compared with bromocriptine in advanced Parkinson's disease with motor complications. (unboundmedicine.com)
Bromocriptine has a number of other legitimate medical uses, including treatment of Parkinson's Disease and the lowering of prolactin levels in people suffering from prolactin secreting tumors. (mindandmuscle.net)
Here, we report four cryoelectron microscopy (cryo-EM) structures of D1R-G s and D2R-G i signaling complexes with selective and non-selective dopamine agonists, including two currently used anti-Parkinson's disease drugs, apomorphine and bromocriptine. (rcsb.org)
Generic for Parlodel* (Bromocriptine) is used to treat a variety of medical conditions, including Parkinson's disease, menstrual problems, infertility, and abnormal milk production in men or women. (internationaldrugmart.com)
Bromocriptine (BCT) is a dopamine D2 receptor agonist used for the treatment of Parkinson's disease and hyperprolactinemic disorders. (aspetjournals.org)
Parlodel (Bromocriptine) is a dopamine agonist used to treat menstrual and infertility disorders, and to treat parkinson's disease. (medformula.com)
Parkinson's disease: an open label trial of pergolide in patients failing bromocriptine therapy. (bmj.com)
Sixty-three patients with Parkinson's disease who failed bromocriptine therapy for various reasons were treated in an open-label trial of pergolide. (bmj.com)
Bromocriptine has been related to somnolence and episodes of sudden sleep onset, significantly in sufferers with Parkinson's disease. (climb-asia.com)
Nationwide multicenter prospective study on the long-term effects of bromocriptine for Parkinson's disease. (curehunter.com)
A 10-year nationwide multicenter prospective study on the long-term efficacy of bromocriptine for Parkinson's disease is reported. (curehunter.com)
Bromocriptine is an agonist of D2 dopamine receptors and has therefore been used as a treatment for Parkinson's disease. (chemeurope.com)
Bromocriptine is also used to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. (pharmacy-network.com)

Therefore, the baseline condition is different in lean or obese subjects which may cause different effects of bromocriptine treatment. (clinicaltrials.gov)

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Your doctor will probably start you on a low dose of bromocriptine and gradually increase your dose, not more than once every 2 to 28 days. (medlineplus.gov)
However, elderly patients are more likely to have confusion, hallucinations, or uncontrolled body movements, and age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving bromocriptine. (mayoclinic.org)
However, elderly patients are more sensitive to the effects of this medicine than younger adults and are more likely to have confusion, hallucinations, or uncontrolled body movements, and age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving bromocriptine. (mayoclinic.org)
The specific dose of bromocriptine will depend on the condition being treated and the needs of the person. (medbroadcast.com)
Five of seven patients with chronic nonfluent aphasia and hemiparesis due to a focal ischemic infarction developed painful hemidystonia during treatment with a high dose of bromocriptine. (ovid.com)
The ipsilateral turning induced by bromocriptine was significantly potentiated by the coadministration of a low dose but not by a high dose of LEK-8829. (aspetjournals.org)
The potentiation of ipsilateral turning suggests the costimulation of D 2 and D 1 receptors by bromocriptine and LEK-8829, respectively, whereas the lack of potentiation by the highest dose of LEK-8829 may be explained by the opposing activity of LEK-8829 and bromocriptine at D 2 receptors. (aspetjournals.org)
Ten T2DM subjects on metformin (1-2 gm/day) and high-dose (TDID ≥ 65 U/day) basal-bolus insulin were enrolled to receive once daily (morning) bromocriptine-QR (1.6-4.8 mg/day) for 24 weeks. (harvard.edu)
In this study, bromocriptine-QR therapy improved glycemic control and meal tolerance while reducing insulin requirement in T2DM subjects poorly controlled on high-dose insulin therapy. (harvard.edu)

Bromocriptine is a dopamine D2 receptor agonist, and bromocriptine-QR was designed to provide a short duration pulse of this dopamine agonist to centers in the brain ( 12 , 13 ) that regulate peripheral fuel metabolism ( 14 ). (diabetesjournals.org)
Bromocriptine is an ergot alkaloid dopamine D(2) receptor agonist that has been used extensively in the past to treat hyperprolactinaemia, galactorrhoea and Parkinsonism. (diabeticmediterraneandiet.com)
Although bromocriptine was originally described as a dopamine receptor agonist/antagonist [ 9 ], its mechanism of action for each disease is partially unknown. (biomedcentral.com)

Tell your doctor right away if you become pregnant while taking bromocriptine. (cigna.com)

Bromocriptine oral tablet is available as a generic drug and as brand-name drugs. (healthline.com)
Bromocriptine belongs to a class of drugs called ergot derivatives. (healthline.com)
What drugs interact with bromocriptine? (sharecare.com)
Bromocriptine is in a group of drugs called dopamine receptor agonists. (pharmacy-network.com)
Bromocriptine has been in use for many years to treat other conditions, so we may not see any of the unforeseen consequences that have led to so many drugs being pulled from the market a couple years after FDA approval. (diabeticmediterraneandiet.com)

Bromocriptine is used to treat issue, for instance, amenorrhea (unlucky deficiency of a menstrual period), productive chest milk creation, unprofitability, and diverse conditions associated with high prolactin levels made by prolactin-releasing tumors in women and in men. (medicinesmexico.com)
Bromocriptine is also used to treat these disorders when they are caused by brain tumors that can produce prolactin. (pharmacy-network.com)
Bromocriptine is also used to treat prolactin-secreting tumors. (healthpluspharmacy.com)
Bromocriptine can be used to treat such disorders caused by high prolactin levels as amenorrhea (lack of a menstrual period), infertility, persistent breast milk production, and other conditions associated with high prolactin levels caused by prolactin-secreting tumors for women and men. (ampills.com)

Patients: This was a randomized controlled clinical trial to compare the effectiveness of cabergoline versus bromocriptine in hyperprolactinemic infertile women undergoing induction of ovulation for intrauterine insemination (IUI). (biomedsearch.com)

Compared with placebo, bromocriptine was associated with a significant reduction in serum prolactin levels (weighted mean difference -195.3 micro international units per litre, 95% confidence interval -276.5 to -114). (nih.gov)
Thorner M.O., Schran H.F., Evans W.S., Rogol A.D., Morris J.L., MacLeod R.M. A broad spectrum of PRL suppression by bromocriptine in hyperprolactinemic women: a study of serum prolactin and bromocriptine levels after acute and chronic administration of bromocriptine. (springer.com)

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Erythromycin alters the pharmacokinetics of bromocriptine by inhibition of organic anion transporting polypeptide C-mediated uptake. (webmd.com)
Lancranjan I., Rolland R., L'Hermite M. Inhibition of lactation with depot-bromocriptine. (springer.com)

Bromocriptine (Parlodel) comes as a capsule and a tablet to take by mouth. (medlineplus.gov)
Bromocriptine comes in two forms: an oral tablet and an oral capsule. (healthline.com)

It has been proposed that the administration of bromocriptine under these circumstances might counteract a prolactin-induced block on the action of gonadotrophins on the testicles and, subsequently, that the reduction in prolactin levels might lead to an improvement in semen parameters and fertility. (nih.gov)
There is not enough evidence to show that bromocriptine is helpful in improving fertility. (nih.gov)
A comparison of bromocriptine & cabergoline on fertility outcome of hyperprolactinemic infertile women undergoing intrauterine insemination. (biomedsearch.com)
Bromocriptine may enhance fertility in women with prolactin disorders. (foundhealth.com)

Bromocriptine oral tablet is often used as part of a combination therapy. (healthline.com)
Bromocriptine oral tablet is used to treat several conditions. (healthline.com)
Bromocriptine oral tablet can cause dizziness and drowsiness during the first few hours after you take it. (healthline.com)

Should l start taking bromocriptine? (drugs.com)

Recently, a new long-acting form of bromocriptine (Parlodel LA, Sandoz) has been developed and it has already been found to be effective in lowering plasma PRL levels in normal volunteers and postpartum women. (springer.com)
This injectable form of bromocriptine induced nausea and/or mild hypotension Jasting a few h in 4 of the 10 patients and was better tolerated than the oral form as regards both the duration and intensity of the side effects. (springer.com)
Thus, as this drug has proved to be efficacious and well tolerated by the patients, this long-acting form of bromocriptine may be a valid therapeutical approach for initiating medical treatment of patients with prolactinoma. (springer.com)
Montini M., Pagani G., Gianola D., Pagani M.D., Salmoiraghi M., Ferrari L., Lancranjan I. Long-lasting suppression of prolactin secretion and rapid shrinkage of prolactinomas after a long-acting injectable form of bromocriptine. (springer.com)

However, the investigators have shown that bromocriptine did not influence BAT activity or energy expenditure in healthy, lean subjects. (clinicaltrials.gov)
Our previous research has shown that bromocriptine produced significant changes in the heart and kidneys amino acid contents. (thescipub.com)

Effective treatment with BROMOCRIPTINE results in a reduction in hyperprolactinaemia and sometimes to decision of the visual impairment. (climb-asia.com)
Patients have to be informed of this and advised to exercise warning while driving or operating machines throughout treatment with bromocriptine. (climb-asia.com)
The influence of chronic treatment with bromocriptine 20 mg kg day -1 i.p, sulpiride 20 mg kg day -1 i.p. or their combination bromocriptine 20 mg kg day -1 i.p + sulpiride 20 mg kg day -1 i.p. for 6 weeks on free amino acids in the brain and the plasma of rats were carried out. (thescipub.com)
Treatment with bromocriptine reduced cell viability of AML cells by activation of the apoptosis program and induction of myeloid differentiation. (biomedcentral.com)
Immunohistological staining for proliferating cell nuclear antigen (PCNA) revealed that the PCNA labeling index of PRL-producing cells was significantly decreased by treatment with Bromocriptine or terguride compared with untreated cells. (pills2021.ru)

When administered in the early morning at the start of the light phase, a new quick release (QR) formulation of bromocriptine appears to act centrally to reset circadian rhythms of hypothalamic dopamine and serotonin and improve insulin resistance and other metabolic abnormalities. (diabeticmediterraneandiet.com)
Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM. (diabeticmediterraneandiet.com)

Effects of cocaine alone and in combination with bromocriptine in human cocaine abusers. (chemeurope.com)

A recently launched long acting dopaminergic drug, cabergoline, has been shown to have advantages over bromocriptine in terms of both efficacy and tolerability. (biomedsearch.com)
Bromocriptine-QR is administered in the morning, within 2 h of waking, to effectuate an increase in central dopaminergic tone at the time of day it normally peaks in healthy individuals ( 15 ). (diabetesjournals.org)
Thus, bromocriptine induced hallucination is related to non dopaminergic action. (thescipub.com)
Bromocriptine stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects. (drugbank.com)
Increased dopaminergic activity in the tuberoinfundibular pathway inhibits prolactin secretion making bromocriptine an effective agent for treating disorders associated with hypersecretion of prolactin. (drugbank.com)

Bromocriptine mesilate (PH: Ph. (drugs.com)
Bromocriptine Mesilate and breastfeeding. (e-lactancia.org)
We do not have alternatives for Bromocriptine Mesilate . (e-lactancia.org)

Bromocriptine is in a class of medications called dopamine receptor agonists. (medlineplus.gov)
Both lisuride and bromocriptine improved motor fluctuations with no significant differences between the agonists. (unboundmedicine.com)

Bromocriptine is a prescription drug. (healthline.com)
If Bromocriptine was eventually administered to suppress lactation but afterwards the mother is willing to resuming breastfeeding, the mother can do it immediately, trying to minimize the drug effect by frequent suckling the child to stimulate milk production. (e-lactancia.org)
Bromocriptine, a drug that mimics the action of the naturally occurring neurotransmitter dopamine, has a long history of use by body builders and life extension enthusiasts. (mindandmuscle.net)
Silagra is a generic version of the brand name drug called Viagra bromocriptine . (campusone.in)
Generic drug Bromocriptine is considered just as safe and effective as its brand-name equivalents such as Parlodel and Kripton. (internationaldrugmart.com)
Did you know that buying the generic drug Bromocriptine from IDM is much cheaper than buying the Parlodel or Kripton brand drug? (internationaldrugmart.com)
Drug interactions might happen either when Bromocriptine is taken along with another drug or with particular foods. (internationaldrugmart.com)
So in effect, Parlodel (Bromocriptine) is used as a drug that mimicks the effect of Dopamine, thus inhibiting the production of Prolactin, as well. (medformula.com)
There are also other conditions not mentioned above wherein Bromocriptine is used as a drug of choice. (medformula.com)
Since Parlodel (Bromocriptine) has been known to make people drinking this drug feel drowsy and sleepy, it is important to tell your physician if you usually have problems staying awake and alert during daytime. (medformula.com)
Bromocriptine may moreover be used for purposes other than those recorded in this drug guide. (medicinesmexico.com)
I updated my brief bromocriptine drug review of May 14, 2009. (diabeticmediterraneandiet.com)
Bromocriptine: old drug, new formulation and new indication. (diabeticmediterraneandiet.com)
Our results support the use of bromocriptine as an anti-AML drug in a repositioning setting and the further clinical validation of this preclinical study. (biomedcentral.com)

Bromocriptine reduces these hormone levels, which in turn treats the conditions. (healthline.com)
Bromocriptine reduces the amount of the hormone prolactin that's produced by the body. (healthline.com)
Bromocriptine Prolactin has been used to help restore ovulation in women and it can both increase Growth Hormone (GH) levels in people with normal concentrations, as well as suppress GH secretion in those suffering from excessive GH production in their bodies. (antiaging-systems.com)
Similarly, bromocriptine diminishes improvement hormone levels. (medicinesmexico.com)
Bromocriptine is used to suppress prolactin, the hormone that stimulates milk production. (myfertility.ca)
Bromocriptine can lower these hormone levels, but it does not cure the causes of the increased levels. (healthpluspharmacy.com)

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Randomised trials of oral bromocriptine versus placebo or no treatment for couples with subfertility attributed to male factor. (nih.gov)

Lisuride and bromocriptine produced similar benefits in parkinsonian impairments according to the Columbia Rating Scale. (unboundmedicine.com)

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Bromocriptine appears to reduce prolactin levels in subfertile men with normal gonadotrophic function. (nih.gov)

Bromocriptine belongs to a group of medications called ergot alkaloids . (medbroadcast.com)
Methods and Results: Three thousand seventy T2DM subjects on stable doses of ≤2 antidiabetes medications (including insulin) with HbA1c ≤10.0 (average baseline HbA1c=7.0) were randomized 2:1 to bromocriptine-QR (1.6 to 4.8 mg/day) or placebo for a 52-week treatment period. (harvard.edu)
The medications, bromocriptine and cabergoline, work to decrease the prolactin levels and therefore decrease the symptoms. (truly-md.com)

Objective: The aim of this study is the evaluation of bromocriptine on insulin resistance in PCO people. (scirp.org)
A co-secondary objective of the study will be to assess the impact of Bromocriptine-QR vs Placebo on measures of insulin resistance and glycemic control (e.g., oral glucose tolerance test (OGTT) glucose and insulin, Matsuda index, Homeostasis Model Assessment-insulin resistance (HOMA-IR), Hemoglobin A1c (HbA1c). (clinicaltrials.gov)
Lack of evidence for bromocriptine effect on glucose tolerance, insulin resistance, and body fat stores in obese type 2 diabetic patients. (diabetesjournals.org)
Quick-release bromocriptine acts on circadian neuronal activities within the hypothalamus to reset the abnormally elevated hypothalamic drive for increased plasma glucose, triglyceride, and free fatty acid levels in fasting and postprandial states in patients with insulin resistance. (medscape.com)

Bromocriptine stimulates dopamine receptors in the brain. (healthline.com)

No Prescription Needed for Bromocriptine. (lanyrd.com)
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Follow the Bromocriptine dosage prescribed by your physician. (internationaldrugmart.com)
In these instances the visual subject defect may improve on reduction of bromocriptine dosage whereas there is some elevation of prolactin and some tumour re-growth. (climb-asia.com)
bromocriptine Treatment And Success bromocriptine The traditional therapeutic dosage in these patients is 5-7.5 mg daily but ranges from 2.5-15 mg daily. (climb-asia.com)

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Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (1/485)

Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors. (2/485)

Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. (3/485)

The lipoprotein profile of women with hyperprolactinaemic amenorrhoea. (4/485)

Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha1D Ca2+ channel gene expression. (5/485)

Reduction of plasma gonadotropin levels and pituitary tumor size by treatment with bromocriptine in a patient with gonadotropinoma. (6/485)

Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak. (7/485)

Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa. (8/485)

Bromocriptine

Ergolines

Prolactin

Prolactinoma

Lisuride

Hyperprolactinemia

Dopamine Agonists

Pituitary Neoplasms

Hormone Antagonists

Galactorrhea

Metoclopramide

Pergolide

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Levodopa

Pimozide

Acromegaly

Domperidone

Receptors, Dopamine D2

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Cyproheptadine

Akinetic Mutism

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Growth Hormone

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Ergotamine

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Internet

American Hospital Association

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Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (1/485)

Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors. (2/485)

Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. (3/485)

The lipoprotein profile of women with hyperprolactinaemic amenorrhoea. (4/485)

Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha1D Ca2+ channel gene expression. (5/485)

Reduction of plasma gonadotropin levels and pituitary tumor size by treatment with bromocriptine in a patient with gonadotropinoma. (6/485)

Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak. (7/485)

Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa. (8/485)

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