A sedative and mild hypnotic with potentially toxic effects.

Determination of (+)- and (-)-bromoisovalerylurea in sera of overdosed subjects. (1/10)

Bromoisovalerylurea (bromisovalum) is a sedative-hypnotic given orally as a racemic mixture of optical isomers (i.e., (+)- and (-)-enantiomer) and frequently taken in overdose in order to commit suicide. Sera from 16 overdosed subjects were analyzed for each enantiomer by high-performance liquid chromatography on chiral stationary phases. The (+)-enantiomer concentration was lower than the (-)-enantiomer concentration in all specimens, that is, the ratio of the (+)-enantiomer to the total concentration ranged from about 50% to 0%. The ratio of the (+)-enantiomer was continuously decreasing in each subject. The data indicate that the drug in gastrointestinal tract was absorbed into blood nonstereoselectively and that the drug in blood was eliminated stereoselectively. The enantioselective determination of this drug will give useful information on absorption and elimination.  (+info)

Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion. (2/10)

The relationship between hepatic glutathione content and hepatic glutathione conjugation rate in the rat in vivo was investigated. As substrate for glutathione conjugation, racemic (R,S)-2-bromoisovalerylurea (BIU) was used which gives rise to the biliary excretion of two diastereoisomeric glutathione conjugates and the urinary excretion of two diastereoisomeric mercapturates. The excretion rate of the glutathione conjugate in bile reflects hepatic conjugation exclusively. An intravenous infusion of BIU was given and the excretion rates of the metabolites in bile and urine were determined. The glutathione concentration in the liver was followed by taking biopsies every hour. Glutathione was depleted by the infused substrate; in rats that were pretreated with the inhibitor of glutathione biosynthesis, buthionine sulphoximine (BSO), the depletion of the glutathione content was more rapid. The rate of excretion of the glutathione conjugate in bile was plotted against hepatic glutathione content. These results indicate that the 'organ Km' for glutathione in the liver is approximately 0.5 mumol/g of liver, so that the hepatic glutathione conjugation rate is decreased only at severe glutathione depletion.  (+info)

Method for screening and quantitative determination of serum levels of salicylic Acid, acetaminophen, theophylline, phenobarbital, bromvalerylurea, pentobarbital, and amobarbital using liquid chromatography/electrospray mass spectrometry. (3/10)

We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical setting. The method employs liquid chromatography/electrospray mass spectrometry (LC/MS) of solid-phase extracted serum samples. For LC/MS ionization, the electrospray-ionization method was used, with acetaminophen in the positive-ion mode, and salicylic acid, theophylline, phenobarbital, bromvalerylurea, pentobarbital, amobarbital, and o-acetamidophenol (internal standard) in the negative-ion mode, the base ions were used in each case for quantitative analysis. Quantitation was possible for the following sample concentration ranges: salicylic acid and acetaminophen, 100 to 5 microg/ml; theophylline, 100 to 0.5 microg/ml; and phenobarbital, bromvalerylurea, pentobarbital, and amobarbital, 100 to 1 microg/ml. Using full-scan mass spectrometry, the lower detection limits of 1 microg/ml for salicylic acid and acetaminophen, 0.1 microg/ml for theophylline, and 0.5 microg/ml for phenobarbital, bromvalerylurea, pentobarbital, and amobarbital were adequate for identifying acute poisoning. When each compound was added to serum to a final concentration of 5 microg/ml and solid-phase extraction was performed using Oasis HLB 1-cc (30-mg), the mean recovery rate of each compound was 89.2 to 96.1% (n=5), and the coefficients of variation of the intraday and interday assays were 3.55 to 6.05% (n=5) and 3.68 to 6.38% (n=5), respectively, which are acceptable. When this method of analysis was applied in testing the sera of a female patient who had consumed a large amount of an unknown commercial drug, salicylic acid and bromvalerylurea were identified, and the treatment strategy could be determined in accordance with the serum concentration of those drugs.  (+info)

Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man. (4/10)

1. alpha-Bromoisovalerylurea (BIU) is a racemic drug that is metabolized by glutathione conjugation. The urinary excretion of the separate diastereomeric mercapturates formed from (S)- and (R)-BIU in healthy young human volunteers was investigated. 2. A pronounced stereoselectivity was observed: the mercapturate formed from R-BIU was excreted with a t1/2 of 1.5 +/- 0.4 h, while that from S-BIU showed a t1/2 of 3.1 +/- 1.3 h. Moreover, 22.5 +/- 4.3 and 5.7 +/- 1.6% of the dose, respectively, was excreted as each mercapturate diastereomer in 24 h. 3. This is the first example of stereoselectivity in the elimination of a substrate for glutathione conjugation in man.  (+info)

Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers. (5/10)

The stereoselectivity of purified rat GSH transferases towards alpha-bromoisovaleric acid (BI) and its amide derivative alpha-bromoisovalerylurea (BIU) was investigated. GSH transferase 2-2 was the only enzyme to catalyse the conjugation of BI and was selective for the (S)-enantiomer. The conjugation of (R)- and (S)-BIU was catalysed by the isoenzymes 2-2, 3-3 and 4-4. Transferase 1-1 was less active, and no catalytic activity was observed with transferase 7-7. Isoenzymes 1-1 and 2-2 of the Alpha multigene family preferentially catalysed the conjugation of the (S)-enantiomer of BIU (and BI), whereas isoenzymes 3-3 and 4-4 of the Mu multigene family preferred (R)-BIU. The opposite stereoselectivity of conjugation of BI and BIU previously observed in isolated rat hepatocytes and the summation of activities of enzymes known to be present in hepatocytes on the basis of present data are in accord.  (+info)

Cerebellar atrophy due to chronic bromisovalum abuse demonstrated by computed tomography. (6/10)

Two patients with a severe cerebellar syndrome due to chronic bromisovalum usage are described. In both patients CT scan revealed severe cerebellar atrophy. The value of computed tomography in detecting irreversible cerebellar lesions due to bromisovalum is discussed.  (+info)

Cerebellar ataxia and peripheral neuropathy due to chronic bromvalerylurea poisoning. (7/10)

A patient with chronic bromvalerylurea poisoning showed cerebellar ataxia and peripheral neuropathy. The patient was a 42-year-old Japanese man who developed consciousness disturbance, diplopia, slurred speech, ataxia and gait disturbance after having taken bromvalerylurea for ten years. Magnetic resonance imaging revealed atrophy of the cerebellum and pontine tegmentum. An electrophysiological study revealed decreased motor nerve conduction velocity and amplitude of compound muscle action potentials of the right tibial nerve. Histological findings of the left sural nerve indicated a slightly decreased large myelinated fiber diameter, which suggested chronic axonal damage.  (+info)

Chronic bromvalerylurea intoxication: dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse. (8/10)

Nalon-Ace and other nonsteroidal anti-inflammatory drugs (NSAID) containing bromvalerylurea (BVU) are sold as over-the-counter (OTC) drugs and are obtainable without prescription in Japan. A 32-year-old woman was diagnosed as having chronic BVU intoxication due to habitual use of Nalon-Ace. In addition to cerebellar ataxia and pyramidal signs well known in this condition, she showed an as yet non-described dystonic posture of the neck. Laboratory tests revealed an elevated concentration of serum organic bromide, iron deficiency anemia, and hyperchloremia. Brain magnetic resonance imaging (MRI) revealed definite cerebellar atrophy. We should consider the possibility of chronic BVU intoxication in peculiar neurological cases like ours.  (+info)

Wyatt Technology, the world leader in absolute macromolecular characterization instrumentation and software, showcased its Möbiuζ® electrophoretic mobility instrument, at Pittcon 2013, Philadelphia, PA. The instrument incorporates several patent-pending innovations to realize fast and reliable measurements of macromolecular charge. Besides being capable of swiftly measuring mobilities of large particles such as liposomes and VLPs, Wyatt Technologys Möbiuζ is the only laser-based instrum
It was another traumatic day for the people of Biu local government council of Borno state, when trouble broke out on Thursday, barely ten days after
Predictive in vitro methods to investigate drug metabolism in the human intestine using intact tissue are of high importance. Therefore, we studied the metabolic activity of human small intestinal and colon slices and compared it with the metabolic activity of the same human intestinal segments using the Ussing chamber technique. The metabolic activity was evaluated using substrates to both phase I and phase II reactions: testosterone, 7-hydroxycoumarin (7HC), and a mixture of cytochrome P450 (P450) substrates (midazolam, diclofenac, coumarin, and bufuralol). In slices of human proximal jejunum, the metabolic activity of several P450-mediated and conjugation reactions remained constant up to4hof incubation. In the colon slices, conjugation rates were virtually equal to those in small intestine, whereas P450-mediated conversions occurred much slower. In both organs, morphological evaluation and ATP content implied tissue integrity within this period. P450 conversions using the Ussing chamber ...
chains in the Genus database with same CATH superfamily 2WI4 A; 3A0T A; 4BAE A; 4MOT A; 5J71 A; 1US7 A; 2WI7 A; 4NH8 A; 5CPH A; 1Y8O A; 3RKZ A; 2XJX A; 2YE3 A; 3MNR P; 3ZKD A; 2AKP A; 5F3K A; 2Q8I A; 1NHH A; 2ZDX A; 4XIQ A; 2BT0 A; 2BU6 A; 3INW A; 3PEJ A; 2YEF A; 2Q8H A; 1YC1 A; 2BZ5 A; 2WI1 A; 3CRK A; 3OMU A; 4BXI A; 2XX5 A; 4YKX A; 2BU8 A; 4CWQ A; 4WUC A; 4R3A A; 4U7O A; 4WUD A; 4PU9 A; 1ZXM A; 4E00 A; 4EFT A; 3O0I A; 1ZXN A; 4PL9 A; 2YI0 A; 1Y8N A; 2YKI A; 1KIJ A; 4O09 A; 4EEH A; 2WI3 A; 4ASB A; 4DUH A; 1TH8 A; 3BMY A; 2YGA A; 2YEG A; 4XCL A; 1I59 A; 3U2K A; 2YKJ A; 4B6C A; 2IOR A; 1UYM A; 3U67 A; 2BU2 A; 2XAB A; 1B63 A; 4XKK A; 4E01 A; 3T0Z A; 4EGH A; 2ESA A; 4I5S A; 3TZ2 A; 4BIU A; 2YKE A; 2JJC A; 2FYP A; 2CH4 A; 4ASF A; 3B25 A; 5L3J A; 2GQP A; 4URO A; 1S14 A; 3A0Y A; 4GCZ A; 3H80 A; 3VHA A; 1THN A; 3C11 A; 2FXS A; 3A0X A; 4QPJ A; 1ID0 A; 3GIF A; 1Z5A A; 1UY7 A; 3WHA A; 1QZR A; 5D7R A; 3CGY A; 4GEE A; 4R1F A; 1AH6 A; 1EI1 A; 1QY8 A; 4CWS A; 2XHR A; 4HZ0 A; 4CE2 A; 4L91 A; 2XDL A; 3EHJ A; ...
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An invited post by Erwin Montgomery, M.D., and Michele A. Basso, Ph.D., University of Wisconsin, Madison. Based in part on some of the findings of altered learning in rodent models, a primate model of dystonia was developed. This model revealed that repetitive stimulation of fingers not normally stimulated together resulted in dystonic postures of the…
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chrisnat brudy wyciaga beti na temat irka ja sie nie wpierdalam w jej zycie osobiste a po za tym kazdy ma parwo wyrazac to co mu lezy na watrobie , a dobrze mnie znasz i wiesz ze nie pozwole sobie zeby ktokolwiek robi mi ko o pi ra. Jest takie powiedzenie jak Kuba Bogu tak B g Kubie. w Go biu wszyscy dla siebie byli mili i sympatyczni a za plecami - n . I nie m w mi na temat chrzczenia alhoholu bo wszyscy kelnerzy na dyskotece robili co chcieli z drinkami zw aszcza za czas w gdy sie przyjmowa am do pracy. Aha potrafie sie przyznac do b edu przepraszam beti ze cie wzie m za kogos innego. ...
Alex Evers, MD, Chair of the IARS Board of Trustees says: We are enthused that Dr. Vetter will be joining Dr. Pittet and Anesthesia & Analgesia as the Journals Deputy Editor-in-Chief. Dr. Vetters skill set nicely complements Dr. Pittets and brings additional strength to an already robust editorial board. The IARS Board of Trustees is confident that the new editorial team will build upon Dr. Shafers legacy of creativity and innovation, as well as expanding our Journal into new areas and creating new opportunities for authors ...
However, there are a couple of excellent resources that can help you avoid a lot of these pitfalls. A number of amazing ladies go into the brick & mortar stores when new collections are released, try on as much as they can then post photos and reviews on the Pepperberry Facebook page. It is incredibly helpful to see the items on different body types and to get info regarding sizing, fabric quality etc. before buying. Sadly, even the mere mention of large boobs attracts creepers so some of these ladies have started posting their reviews in the Clothes for Boobs Facebook group instead, as it is a closed group. This group is also absolutely excellent for buying, selling and swapping clothes and bras from all the bust friendly brands, and is the best place to grab a bargain. Its also a great place to ask for sizing advice. There are also a fair amount of Pepperberry/Biu Biu/Urkye clothes that get sold through Ebay, so its well worth checking there regularly ...
div class=citation vocab=http://schema.org/,,i class=fa fa-external-link-square fa-fw,,/i, Data from ,span resource=http://link.mymcpl.org/portal/Tales-from-Earthsea-Studio-Ghibli--screenplay/bIu83WzgPGU/ typeof=Book http://bibfra.me/vocab/lite/Item,,span property=name http://bibfra.me/vocab/lite/label,,a href=http://link.mymcpl.org/portal/Tales-from-Earthsea-Studio-Ghibli--screenplay/bIu83WzgPGU/,Tales from Earthsea, Studio Ghibli ; screenplay written by Goro Miyazaki, Keiko Niwa ; produced by Toshio Suzuki ; directed by Goro Miyazaki, (videorecording),/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof=LibrarySystem http://library.link/vocab/LibrarySystem resource=http://link.mymcpl.org/,,span property=name http://bibfra.me/vocab/lite/label,,a property=url href=http://link.mymcpl.org/,Mid-Continent Public Library,/a,,/span,,/span,,/span,,/span,,/div ...
chains in the Genus database with same CATH superfamily 3UAI C; 2RFK C; 2EY4 C; 3MQK C; 2HVY B; 2V3M A; 2EQN A; 3U28 C; #chains in the Genus database with same CATH topology 3SUF A; 2AEI H; 5DP8 A; 3WY8 A; 1OWI A; 2ZU5 A; 3KHV A; 4Y11 E; 1SGF G; 1NBM D; 3Q3X A; 1C2H A; 4IN1 A; 3RM0 H; 1ZZZ A; 3KQE A; 1GHY H; 1MMJ N; 1TOC B; 3N7E A; 3M5M A; 2R3Y A; 1TPP A; 2P3T B; 5C0U A; 1SOT A; 1GBH A; 2PKS B; 3QX5 H; 3FO8 D; 1ZMN A; 3IIT A; 1C5P A; 4KEL A; 5L2Z H; 1K0H A; 1QGF A; 2THF B; 3GDU A; 5F8Z A; 2KM0 A; 2A4Q A; 1P9S A; 1TMB H; 2ZGX H; 3S9C A; 2ZC9 H; 1O5F H; 1FY1 A; 2BD4 A; 1KLJ H; 3MU8 A; 2OUA A; 3SGB E; 4O9V A; 3K6Z A; 3NK8 A; 4X6M A; 3BIU H; 5JB8 S; 1HDT H; 3URE A; 2DE8 A; 1QRX A; 1OKX A; 4Y8Z A; 1CU1 A; 1EOL A; 1F92 A; 4M7G A; 4B76 A; 1YPL H; 1K22 H; 4I31 A; 1O2K A; 3PLP A; 2FM2 A; 4B73 A; 4I7Y H; 1O5C B; 1OWJ A; 1DFP A; 5IDK A; 4Y8Y A; 4I33 A; 3ZVB A; 1W0Z U; 3RXC A; 1ZGV A; 1XUF A; 1KMH B; 1O2W A; 2C4F H; 4TY6 A; 8KME 2; 1CSO E; 2VID A; 4SGA E; 2DE9 A; 1CE5 A; 5A2M H; 2B8O H; 3M36 A; 4Q7X A; 5T6G ...
The species differences in the bioactivation of FBM are significant and could contribute to an explanation of selective toxicity in humans as compared with rats. The major metabolites of FBM in rats are p-hydroxyfelbamate (37%) and 2-hydroxyfelbamate (25%), (Kucharczyk, 1995) (Fig. 1). A significant portion of the parent drug is also excreted as unchanged drug (32%), (Kucharczyk, 1995). The major metabolites of FBM in humans are MCF-glucuronide (11%), CPPA (13%), and atropaldehyde excreted as mercapturates (6%). As in rats, a significant amount of the FBM is excreted as unchanged drug (47%), (Kucharczyk, 1995). Given the hypothesis that atropaldehyde is the toxic metabolite in FBM bioactivation, a decrease in its production should protect from FBM toxicity.. Our data (Fig. 1) indicate that rats demonstrate a protective metabolism of FBM generating less atropaldehyde (1%). The minor formation of atropaldehyde in rats results from a number of factors including: 1) significant contribution from ...
DSS power supply. The bus interface unit (BUI) is the interface between RADAR and the CDS. On the RADAR side, the BIU interfaces to the flight computer unit for command, software, and data transfers.. The flight computer unit (FCU) receives commands and software from the CDS and sends data and status to CDS by way of the BIU. It depacketizes the commands and provides the RADAR configuration and timing information to the control and timing unit. It also receives housekeeping values in a predetermined order from the low-speed A/D converter and packetizes the housekeeping and science data to be passed to the CDS by way of the BIU. In addition, the FCU receives spacecraft time broadcasts and RADAR software uploads from CDS by way of the BIU. The FCU is built around an engineering flight computer (EFC) with additional banks of ROM and internal interface circuitry.. The purpose of the control and timing unit (CTU) is to control the hardware configuration and the timing of control signals within RADAR. ...
Early Illustrations of Geste Antagoniste (sensory tricks) in Cervical and Generalized Dystonia. December, 2016. Geste antagoniste, or sensory trick, is a voluntary maneuver that temporarily reduces the severity of dystonic postures or movements. We present a historical review of early reports and illustrations of geste antagoniste. Continue Reading. ...
When a single dose of 2 mg labelled ethylene oxide in propanediol/kg body weight was applied intraperitoneally to rats, 43% of the administered radioactivity was excreted in the urine within 50 h (41% within 24 h) of exposure, 9% as S-(2- hydroxyethyl)cysteine and 33% as N-acetyl- S-(2-hydroxyethyl) cysteine, both products of glutathione conjugation. Via the lungs, 1.5% was excreted as carbon dioxide and 1% as unmetabolized ethylene oxide (Jones & Wells, 1981). The involvement of glutathione-epoxide- S-transferase (EC 4.4.1.7) has not been investigated further. In vitro glutathione conjugation of the homologue propylene oxide was shown to proceed only in the presence of an enzyme (Fjellstedt et al., 1973). In rabbits, no effect was found on liver- and blood-glutathione levels, after 12 weeks of exposure to concentrations of ethylene oxide at 18, 90, or 450 mg/m3, for 5 days per week, 6 h per day (Yager & Benz, 1982). As ethylene oxide can react with chloride ions, and this reaction is acid ...
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Printing facilities are available only to students of the Chemistry Department.. Personal advice. Consulting service is designed to give individual assistance by appointment for academic staff and graduate students who write a thesis or doctoral dissertations.. The meetings include a diagnosis of the researchers information needs, guidance for searches and locating of required information items.. For coordination please contact the library: 03-531-8308 or 03-7384450. or by e-mail:. [email protected] [email protected] Trainings The service is designed to give individual support in using the library resources, such as the library catalog, databases and other librarys tools, for students and for academic/administrative staff. Remote Consulting. You can address your questions to the library staff via e-mail:. [email protected] [email protected] or by Tel.: 03-5318308 or 03-7384450, Sun-Thu between 9 a.m.-5.45 p.m. ...
Title:Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation. VOLUME: 10 ISSUE: 2. Author(s):Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam. Affiliation:Celgene Corporation, 10300 Campus Point Dr, Suite 100, San Diego, CA 92121, USA.. Keywords:Biotransformation, CYP, drug discovery, glutathione, mass spectrometry, metabolite identification, metabolism, novel, NMR, purine, structural elucidation.. Abstract:Background: The study of novel sites of metabolism is important in understanding new mechanisms of biotransformation of a particular moiety by metabolic enzymes. This information is valuable in designing metabolically-stable compounds with drug-like properties. It may also provide insights into the existence of active and reactive metabolites. Methods: We utilized small scale incubations to generate adequate amounts of the metabolite of interest. After purification, LC-MS/MS and Proton ...
Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7 ...
TY - JOUR. T1 - The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. AU - Verma, Seema. AU - Ismail, Ayesha. AU - Gao, Xiuhua. AU - Fu, Guilian. AU - Li, Xiaotao. AU - OMalley, Bert W.. AU - Nawaz, Zafar. PY - 2004/10/1. Y1 - 2004/10/1. N2 - We investigated the role of the ubiquitin-conjugating enzyme UBCH7 in nuclear receptor transactivation. Using transient transfection assays, we demonstrated that UBCH7 modulates the transcriptional activity of progesterone receptor (PR) and glucocorticoid, androgen, and retinoic acid receptors in a hormone-dependent manner and that the ubiquitin conjugation activity of UBCH7 is required for its ability to potentiate transactivation by steroid hormone receptors (SHR). However, UBCH7 showed no significant effect on the transactivation functions of p53 and VP-16 activation domain. Depletion of endogenous UBCH7 protein by small interfering RNAs suggests that UBCH7 is required for the proper function of SHR. Furthermore, a ...
BackgroundMyoclonus-dystonia is an autosomal dominantly inherited movement disorder, clinically characterized by myoclonic jerks and dystonic postures or moveme
TY - JOUR. T1 - Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure. AU - Cuzzocrea, Salvatore. AU - Zingarelli, Basilia. AU - OConnor, Michael. AU - Salzman, Andrew L.. AU - Szabo, Csaba. PY - 1998. Y1 - 1998. N2 - 1. Peroxynitrite, a cytotoxic oxidant formed from the reaction of nitric oxide (NO) and superoxide is a mediator of cellular injury in ischaemia/reperfusion injury, shock and inflammation. Here we investigated whether L-buthionine-(S,R)-sulphoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase, alters endothelial and vascular smooth muscle injury in response to peroxynitrite in vitro and during endotoxic shock in vivo. 2. In human umbilical vein endothelial cells and in rat aortic smooth muscle cells, BSO (1 mM, for 24 h) enhanced, whereas glutathione (3 mM) or glutathione ethyl ester (3mM) attenuated the peroxynitrite (100-1000 μM)-induced suppression of mitochondrial ...
The RCVS has recently launched the Mind Matters Initiative to help address mental health and wellbeing issues within the veterinary profession. The RCVS acknowledges that the Mental Health is a significant issue for the veterinary profession and states that the Mind Matters Initiative seeks to work more proactively by increasing the accessibility and acceptance of support, encouraging a culture that is better equipped to talk and deal with stress and related mental health issues, and, ultimately, by helping to reduce such triggers within the profession.. The BVU considers this as one of the most important and beneficial projects the RCVS has launched in the recent times and will fully support the RCVS initiative. Here is the actual content of the RCVS press release followed by comments from the BVU RCVS:. We are today (Dec 11, 2014) launching the Mind Matters Initiative, to help address mental health and wellbeing issues within the veterinary profession. Mental Health is a significant ...
A girl believed to be one of the 219 Chibok schoolgirls in Boko Harams custody for more than 160 days has been found abandoned.. She was picked up at Kwarihi village near Biu in Borno State after being thrown out of a moving Volkswagen Golf car.. She wandered in the bush for two days before she was rescued by villagers.. The Chairman of the Chibok community in Abuja, Hosea Tsambido, recounted this story yesterday.. He spoke at the gathering of the #BringBackOurGirls campaigners on a day Borno State Government announced a scholarship of N1.4million each for 36 girls - among the 57 who escaped on April 15 from abductors.. According to Tsambido, the abandoned girl, who gave her name as Susanna Ishaya, appeared mentally unstable.. He said she had been handed over to one of the Chibok parents who took her to the hospital after which she would be properly questioned.. Tsambido said: One of the girls was ferried in a Volkswagen golf and thrown into the bush about two days ago and she wandered into ...
TY - JOUR. T1 - Characterization of a class alpha glutathione-S-transferase with glutathione peroxidase activity in human liver microsomes. AU - Prabhu, Kumble Sandeep. AU - Reddy, Padala V.. AU - Jones, Emily C.. AU - Liken, Andrew D.. AU - Reddy, C. Channa. PY - 2004/4/1. Y1 - 2004/4/1. N2 - A 25.5kDa class alpha glutathione S-transferase (GST) designated as microsomal Ya-GST or M-GSTA has been purified to electrophoretic homogeneity from human liver microsomes. Limited proteolysis, gel filtration chromatography followed by EDTA, and alkaline Na2CO3 treatments of microsomes indicate that the M-GSTA is intrinsic to the microsomes. Western immunoblot analysis revealed that human liver M-GSTA and the previously reported 17-kDa microsomal GST (FEBS Lett. 315 (1993) 77) did not have immunological cross reactivity. The enzyme showed conjugation activity towards substrates like 1-chloro-2,4-nitrobenzene (CDNB) and 7-chloro-4-nitrobenzo-2- oxa-1,3-diazole, and 4-hydroxy-2-nonenal (4-HNE), a genotoxic ...
Hong Kong Principals Anthology: Stories of Professional Growth of School Principals - it is a collection of real stories of success and struggles as seen through the eyes of principals. The Editorial Team consists of Dr Terry Quong (Chief Editor), Dr Tan Kang, John, Dr Anissa Chan, Dr Cheung Man Biu, Robin and Dr Ho Sai Mun, Stanley. The Principals Capability Framework (PCF), the Guide and the Anthology together illustrate the capabilities of effective principals and help to facilitate individual professional learning. Stories from the Anthology were used in the workshop on how to use the Guide for mentors of the newly appointed principals on June 23, 2016 ...
Pero, Elovi,Enny its clear that you all are from a dysfunctional family. You come on a blog and insult your president? I am typical unhappy with what is happening but I will blame the whole Northerner who hid their jihadist sons and daughters and now it has escalated. Yaradua did not have to go to the creek but the Niger Deltan went in to beg their brothers and they accepted amnesty. You saw it on TV when they where submitting guns and all their armoury. Jonathan against our individual wishes stooped to offer all these but they refused asking that the only solution is that they want to Islamise Nigeria. Why hasnt the Northerners agreed to work with the president? Lots of u want Jonathan personal in Biu and Baga. Americans came here to search but couldnt find any. If Buhari wins the Boko boys will instantly rejaoice Allah Wakubah. The Northern are revolting against southern leadership. Why will your husband,father,son show jihadist trait and you would not report to the army or police? Senator ...
Read research to better understand how mutations impact stereoselectivity in evolved ketoreductases and how it can be important in the development of new biocatalysts.
Karak syndrome is a neurological degenerative disorder involving excess cerebral iron accumulation. The family who the disease was discovered in their siblings lived in Karak, a town in southern Jordan. It is characterized by ataxia, inverted feet (talipes calcaneovarus), dysarthric scanning speech with dystonic features, dystonic movement of the tongue and facial muscles and choreiform movement was present in both upper and lower limbs, being more marked in the lower limbs, along with dystonic posture of the distal feet, bradykinesia present in both upper and lower limbs, dysmetria, dysdiadochokinesia, and intentional tremor were bilateral and symmetrical. Neurodegeneration with brain iron accumulation Iron overload Mubaidin A, Roberts E, Hampshire D, et al. (July 2003). Karak syndrome: a novel degenerative disorder of the basal ganglia and cerebellum. J. Med. Genet. 40 (7): 543-6. doi:10.1136/jmg.40.7.543. PMC 1735513 . PMID 12843330. Retrieved 2009-07-07 ...
A 28-year-old woman with generalized dystonia for years visited our outpatient clinic. She was born preterm at 9 months, and her development slowly decelerated after birth, resulting in microcephaly, short stature, cognitive decline, and dysarthria. However, she was able to uneventfully manage her daily activities and had a cleaning job at a welfare center. She had no family history of dystonia or other neurological disorders. She developed right laterocollis and right torticollis with a mobile portion at the age of 27, which then slowly spread to her trunk and bilateral arms (Supplementary Video 1 and 2 in the online-only Data Supplement). The dystonic postures rapidly exacerbated, severely affecting her walking and sitting. Although a sensory trick was noted, it was insufficient for recovery to the neutral position. She described some sleep benefits, but there was no definite fluctuation of the dystonia. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) score was 30 of 120 on the dystonia ...
Bestelmeyer, P.E.G., Latinus, M., Bruckert, L., Rouger, J., Crabbe, F., & Belin, P. (2012). Implicitly perceived vocal attractiveness modulates prefrontal cortex activity. Cerebral Cortex.22,1263-1270. Bläsing, B., Calvo-Merino, B., Cross, E. S., Honisch, J., Jola, C., & Stevens, C. Neurocognitive control in dance perception and performance. (2012). Acta Psychologica, 139(2), 300-308.. Cross, E. S.,Cohen, N. R., Hamilton, A. F. de C., Ramsey, R., Wolford, G. & Grafton, S. T. (2012).Physical experience leads to enhanced object perception in parietal cortex: Insights from knot tying. Neuropsychologia, 50(14), 3207-3217. * Faculty of 1000 recommended by Patrick Haggard, 12 December 2012 *. Cross, E. S., & Ticini, L. F. (2012). Neuroaesthetics and beyond: New horizons in applying the science of the brain to the art of dance. Phenomenology and the Cognitive Sciences, 11(1), 5 - 16.. Cross, E. S., Liepelt, R., Hamilton, A. F., Parkinson, J., Ramsey, R., Stadler, W., & Prinz, W. (2012). Robotic ...
mm mUU Am TUESDAY, FEBRUARY 1 1, 1837. SEMI-WEEKLY, No. 37, Vol. XXV I Whole No. 1452 PRINTED ANU PUBLISHED UY SCOTT JcW RIGHT. Office on fltnio-slreirt, third door went oftlic Clinton Hank. J. BAll.II VUIIE, EDITOR. From the NowOrlenni Times. THE INVISIBLE GENTLEMAN. Unseen lie slls at your fireside Pursues you closely In your dally walks And with Hire ear, keen eye, and arllve mind, Unserves and solves your every word and net . From time to time lio roughly scrllitilcs .these For Ills memento, and for your comment. Tub Printer; thero ho stands at his case; his eyes fixed on his copy, while his lingers, obedient to biu will, collect thu loiters from their various boxes, and place them together so 9B to iurm words, sentences; cumpleto articles of news, politics, or literature. The musician at the piano can hardly compete wilh the printer in rupidity und precision of his digital motion; like the pianist who pluys with his music box and instrument boforchim, thu printer sees mid comprehends at a ...
one of the first subjects to be taught at the inauguration of BIU in October 1955. Two major changes in recent years have propelled the department forward. Twelve new faculty members have been recruited in a variety of disciplines of chemistry. The department now possesses new capabilites in fields such as computational chemistry, structural biology, magnetic resonance, bio-inorganic chemistry, and nano-materials and devices, alongside the more established fields of medicinal chemistry, organic, inorganic and physical chemistry. No less important was the founding in 2007 of BINA, the Bar-Ilan Institute of Nanotechnology and Advanced Materials. This enterprise, with which 12 chemistry research groups are affiliated, is committed to advancing scientific achievements in the areas of nano-materials, nano-medicine, nano-Energy, nano-magnetism, nano-photonics, and nano-cleantech. In October 2009 six research groups moved into state-of-the-art laboratories in the Nanotechnology Triplex building. The ...
Kenji Watanabe and co-workers from the University of Shizuoka have reported in ACIE on an enzyme system (PsoE (glutathione S-transferase) and PsoF (flavin-containing monooxygenase)) that involves glutathione conjugation of a polyolefinic natural product (presynerazol) to form a glutathione adduct intermediate, which in turn is oxidized to the sulfoxide (by flavin hydroperoxide) and eliminates to form…
Pray for the work of Maitaimako Medical Mission in Nigeria. The organizations January 2018 outreach in Biu Borno state provided eye surgeries to 54 people. Pray for patients who required referrals for treatment and for the next outreach effort in May. ...
Benzoquinone ansamycin (BQA) Hsp90 inhibitors such as 17-DMAG and 17-AAG have off-target toxicities in clinical trials including hepatotoxicity. Mechanisms underlying the toxicity of quinones are a function of their ability to redox cycle and/or arylate cellular nucleophiles at the unsubstituted 19-position of the molecule. Therefore, we designed 19-substituted BQAs to prevent glutathione conjugation and non-specific interactions with protein thiols as an approach to reduce the hepatotoxicity and minimize off-target effects of the BQA class of Hsp90 inhibitors. In this study, the results showed that 19-substituted BQAs did not react with glutathione at the 19-position, while marked reactivity was observed using parent BQAs. Importantly, while parent 17-DMAG induced cell death in primary and cultured mouse hepatocytes, 19-phenyl and 19-methyl 17-DMAG showed reduced toxicity, validating the overall approach. There was no significant difference between the redox cycling ability of either 19-phenyl ...
bvu:BVU_4143 K01186 sialidase-1 [EC:3.2.1.18] , (GenBank) glycoside hydrolase family 33, candidate sialidase (A) MRNPSLLLLIVVFILAPFKLSAAADTVVVRETRIPVLIERQDNELFHLRIEATQSQMLNE VKLDFGKDVNLNEIESVKLYYGGTESVERRGKTYFAPVDYISNNTPGKTLAANTSYSVLK SEVKAPKREVVLKADQKLFPGVNYFWISLQMKPVASILSKVSAEVVEAKIDGQVAPLKIA RKADTHYMGIGVRHAGDDGAAAYRIPGLATSNKGTLLGVYDVRYNNSADLQEYVEIGLSR STDGGQTWEKMRIPMAFGEYDGLPKAQNGVGDPAILVDKKTGTIWIVAAWTHGMGNGRAW WNSQTGMDRNHTAQLMMVKSDDDGKTWSEPMNITEQVKDPSWYFLLQGPGRGISMEDGTL VFASQYIGNDRIPNAGIIYSKDHGKTWNISTLARTNTTESQVAEVEPGVLMLNMRDNRGG SRAVSTTTDLGKTWKEHESSRTALQEPVCMASLISVKAKENVLGKDILLFSNPNDAKNRH SITIKASLDGGVTWLPENQLLLDAGWGWGYSCLTMIDKETVGILYESSVAHMTFQAIKLK DIIKTK ...
Seizures can happen anytime and without warning, it is commonly taken as an oral medicine to prevent the disorder. However, the users may take the drug excessively which can lead to addiction.. When taking amobarbital it is important to take it in moderation because it can generates addiction. Users can easily develop dependency because it can relieve a large amount of pain. Once dependence and tolerance develops, users have a higher risk of drug overdose. Also, users may need to undergo a treatment program to safely withdraw from this drug.. Doctors do not prescribe this drug for lone-term use because of its potential for misuse. The United States law does not permit an individual sale of this drug. The law can punish those people who transfer their prescription to others who seek the drug.. ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The preparation of hepatocytes using the two-stage perfusion technique usually involves the use of collagenase (CII) alone or in combination with dispase (C/D) or trypsin inhibitor (CA/TI) as digestion enzymes. The effect of CII, C/D and CA/TI on cell viability, yield, cytochrome P450 mediated oxidation of testosterone, glucuronidation and sulfation of 7-hydroxycoumarin, glutathione content, glutathione-S-transferase activity and glutathione-conjugation capacity of hepatocytes has been assessed. Cytochrome P450 mediated oxidation of testosterone was significantly (p , 0.05) decreased with CII isolated hepatocytes (81.7 +/- 3.3 nmol/10(6) cells, mean +/- S.E.M., n = 3), compared with those isolated using CA/TI (96.6 +/- 1.9 nmol/10(6) cells) or C/D (95.1 +/- 2.1 nmol/10(6) cells). In contrast, glutathione conjugation of the non-specific substrate 1-chloro-2,4-dinitrobenzene was significantly (p , 0.05) increased with CII isolated hepatocytes (56.9 +/- 5.9 nmol/10(6) cells, mean +/- S.E.M., n = ...
BROMISOVALUM. BROMOCRIPTINE AND ITS SALTS. BROMOFORM. BUNAMIDINE HYDROCHLORIDE. BUPIVACAINE HYDROCHLORIDE. BUQUINOLATE. ...
Bromisovalum Current Synonym true false 496780018 Bromisoval Current Synonym true false 89492016 Bromisovalum Current Synonym ...
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Bromisovalum. *Bromocriptine (Parlodel, Cycloset, Brotin) (see Bromocriptine, [[Bromocriptine]]). *Brompheniramine (see ...
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Weight change and risk of cardiovascular disease among adults with type 2 diabetes: more than 14 years of follow-up in the Tehran Lipid and Glucose Study. Cardiovasc Diabetol. 2021 07 12; 20(1):141 ...
This graph shows the total number of publications written about "Biureas" by people in this website by year, and whether "Biureas" was a major or minor topic of these publications ...
Sensitive and selective determination of bromisovalum by HPLC/particle beam mass spectrometry. T. Nagata, K. Kudo, T. Imamura ... Title: Bromural - Bromisovalum. Post by: Rhodium on October 21, 2004, 01:42:00 AM The synthesis is definitely on page 999 in ... has facilitated determination of bromisovalum in human plasma and whole blood. Bromisovalum, a sedative and hypnotic, was ... This method could be practically applied to detect bromisovalum in the whole blood of an autopsied individual. ...
Bromisovalum Preferred Term Term UI T005597. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bromisovalum Preferred Concept UI. M0002944. Registry Number. 469GW8R486. Related Numbers. 496-67-3. Scope Note. A sedative and ... Bromisovalum. Tree Number(s). D02.065.950.160. Unique ID. D001968. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001968 ...
Bromisovalum Preferred Term Term UI T005597. Date01/01/1999. LexicalTag NON. ThesaurusID ... Bromisovalum Preferred Concept UI. M0002944. Registry Number. 469GW8R486. Related Numbers. 496-67-3. Scope Note. A sedative and ... Bromisovalum. Tree Number(s). D02.065.950.160. Unique ID. D001968. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001968 ...
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Metano Modeling Toolbox (MMTB) web service
... brominations bromindione bromine bromines brominised brominism brominized bromism bromisodrophobia bromisoval bromisovalum ...
Bromides N0000166170 Bromine N0000166196 Bromine Compounds N0000166092 Bromine Radioisotopes N0000166305 Bromisovalum ...
ACETAMINOPHEN (EQ TO PARACETAMOL), ASPIRIN, CAFFEINE, BROMISOVALUM ( EQ TO BROMOVALERYLUREA) ( EQ TO BROMVALETONE). 2015-10-28 ... ACETAMINOPHEN (EQ TO PARACETAMOL), ETHENZAMIDE (ETHOXYBENZAMIDE), CAFFEINE ANHYDROUS, BROMISOVALUM ( EQ TO BROMOVALERYLUREA) ( ... ACETAMINOPHEN (EQ TO PARACETAMOL), ETHENZAMIDE (ETHOXYBENZAMIDE), CAFFEINE ANHYDROUS, BROMISOVALUM ( EQ TO BROMOVALERYLUREA) ( ... ACETAMINOPHEN (EQ TO PARACETAMOL), ETHENZAMIDE (ETHOXYBENZAMIDE), CAFFEINE ANHYDROUS, BROMISOVALUM ( EQ TO BROMOVALERYLUREA) ( ...
HYPNOTICS AND SEDATIVES BROMISOVALUM HYPNOTICS AND SEDATIVES CHLORAL HYDRATE HYPNOTICS AND SEDATIVES CHLORALOSE HYPNOTICS AND ... CENTRAL NERVOUS SYSTEM AGENTS BROMISOVALUM CENTRAL NERVOUS SYSTEM AGENTS BROMOCRIPTINE CENTRAL NERVOUS SYSTEM AGENTS BUFOTENIN ... NONBARBITURATE BROMISOVALUM SEDATIVES, NONBARBITURATE CHLORAL HYDRATE SEDATIVES, NONBARBITURATE CHLORALOSE SEDATIVES, ... CENTRAL NERVOUS SYSTEM DEPRESSANTS BROMISOVALUM CENTRAL NERVOUS SYSTEM DEPRESSANTS BUPIVACAINE CENTRAL NERVOUS SYSTEM ...
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