Anti-Anxiety Agents
Nordazepam
Enzyme Multiplied Immunoassay Technique
Event-Related Potentials, P300
A late-appearing component of the event-related potential. P300 stands for a positive deflection in the event-related voltage potential at 300 millisecond poststimulus. Its amplitude increases with unpredictable, unlikely, or highly significant stimuli and thereby constitutes an index of mental activity. (From Campbell, Psychiatric Dictionary, 6th ed)
Polyporus
Equilin
Benzodiazepines
Anxiety
Canada
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Pheromones, Human
Copyright
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Commerce
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Mass Spectrometry
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Propionibacterium acnes
Diazepam
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Drug Approval
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Organic Chemistry Phenomena
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Lorazepam
Vaccinium macrocarpon
Investigation into some aspects of EMIT d.a.u., TLC, and GC-MS urinalysis of bromazepam. (1/15)
Among the different 1,4-benzodiazepine urinary metabolites, those of bromazepam possess distinctive chemical features that may be used in their selective isolation and detection. The detection of bromazepam metabolites in urine was carried out using EMIT d.a.u., thin-layer chromatography (TLC), and gas chromatography-mass spectrometry (GC-MS). The positive EMIT d.a.u. benzodiazepine assay for bromazepam was found to be due to the 3-hydroxybromazepam (3HOB) metabolite. The detection by TLC and GC-MS was carried out after enzyme or acid hydrolysis of the glucuronide conjugates. Both the 2-amino-3-hydroxy5-bromobenzoylpyridine (AHBBP) metabolite and the acid hydrolysis product of 3-HOB, 2-amino-5-bromobenzoylpyridine (ABBP), were selectively detected by TLC. The bromazepam metabolites in urine could be both isolated and detected selectively by GC-MS in the presence of the metabolites of other 1,4-benzodiazepines that were sometimes used in combination with bromazepam. Both 3-HOB and AHBBP were detected by GC-MS only after trimethylsilyl (TMS) derivatization and not as the free compounds or the acetyl derivatives. Only ABBP was detected in three forms: ABBP, the TMS derivative, and the acetyl derivative. Evidence has been obtained from the enzyme hydrolysis and the TLC studies for the formation of the glucuronide conjugate of AHBBP at the 3-OH group rather than at the 2-NH2 group. All the results have been validated using reference 3-HOB and AHBBP. (+info)Hair to document drug-facilitated crimes: four cases involving bromazepam. (2/15)
The use of a drug to modify a person's behavior for criminal gain is not a recent phenomenon. However, the recent increase in reports of drug-facilitated crimes (sexual assault, so-called DFSA, robbery) has caused alarm in the general public. Drugs used can be difficult to detect (active products at low dosages, chemical instability), possess amnesic properties, and can be quickly cleared from body fluids. In case of long delay between the alleged crime and clinical examination, collection of blood or even urine can be of little value. This is the reason why this laboratory developed an original approach based on hair testing by liquid chromatography-tandem mass spectrometry. To explore the detectability of a single absorption of bromazepam in hair, two volunteers (male and female) received a 6-mg dose. A strand of hair was sampled about one month after exposure and was cut into three segments of 2-cm long. After pulverization, 20 mg of hair was incubated overnight in a phosphate buffer (pH 8.4). The aqueous phase was extracted with 5 mL of a mixture of diethyl ether/methylene chloride (80:20) in the presence of diazepam-d5, which was used as internal standard (IS). Hair extract was separated on a XTerra MS C18 column using a gradient of acetonitrile and formate buffer. Detection was based on two daughter ions: transitions m/z 316.0 to 182.2 and 209.3 and m/z 290.1 to 154.1 and 198.2 for bromazepam and the IS, respectively. In the hair of the two subjects, bromazepam was detected in the proximal segment at 0.8 and 4.7 pg/mg, respectively. Hair analysis was applied to four authentic criminal cases. In the two first cases, bromazepam tested positive in the corresponding hair segment at 5.7, and 10.3 pg/mg. In another case, head hair was sampled 19 weeks after the alleged offense, and its length (< 4 cm) did not allow analysis of the corresponding period. However, 4.1 pg/mg of bromazepam was quantified in the victim's pubic hair. In these three cases, concentrations were consistent with a single exposure to bromazepam. In the last case, bromazepam was detected at 15 pg/mg in the segment corresponding to the period of the alleged offence but also in the range 2 to 7 pg/mg in the four other consecutive segments, making a single exposure statement difficult. (+info)[Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study]. (3/15)
The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information. OBJECTIVE: To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database. METHOD: 15 right-handed individuals (7 male and 8 female), between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design. RESULTS: Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database. CONCLUSION: The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning. (+info)Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300). (4/15)
Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3 mg) on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3 mg) on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed. (+info)Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models. (5/15)
The behavioral and clinical profiles of various benzodiazepines after acute and chronic treatment are not well defined and may differ. The aim of this study was to evaluate the behavioral profiles of alprazolam, bromazepam, diazepam and lorazepam in mice after single and repeated (every half-life for seven half-lives) administrations using a stimulation-sedation test (actimeter), a myorelaxation test (rotarod), and an anxiolysis test ("four plates"). A dose range from 0.03 to 4 mg/kg was used. A single administration of alprazolam showed stimulating and anxiolytic effects which diminished after repeated administration. Lorezapam's sedative effect diminished but its anxiolytic effect increased upon repeated administration. Except for lorazepam, the myorelaxing effect of all four drugs increased after repeated treatment. These results suggest that the behavioral profile of benzodiazepines may not be identical during acute and chronic treatment. These differences may be present in clinical treatment and warrant investigation in humans. (+info)Influence of bromazepam on cortical interhemispheric coherence. (6/15)
Benzodiazepines are among the most commonly prescribed medications due to their therapeutic efficacy in reducing anxiety and inducing sleep. Consequently, they have been widely employed in the pharmacological treatment of several disorders. Nevertheless, few studies have analyzed the effects of bromazepam in electroencephalographic activity (EEG). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on EEG coherence were tested in a double-blind experiment. The sample, consisting of 10 healthy subjects (5 male and 5 female), was submitted to ten minutes of EEG recording. The electrophysiological measure (coherence) was analyzed across three experimental conditions: bromazepam, placebo 1, and placebo 2. Results indicate that bromazepam significantly increases cortical interhemispheric coherence. (+info)The effects of bromazepam on the early stage of visual information processing (P100). (7/15)
The early stages of visual information processing, involving the detection and perception of simple visual stimuli, have been demonstrated to be sensitive to psychotropic agents. The present study investigated the effects of an acute dose of bromazepam (3 mg), compared with placebo, on the P100 component of the visual evoked potential and reaction time. The sample, consisting of 14 healthy subjects (6 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Results suggest that bromazepam (3 mg) impairs the initial stage of visual information processing, as observed by an increase in P100 latency. (+info)Alterations in brain 5-hydroxytryptamine metabolism during the 'withdrawal' phase after chronic treatment with diazepam and bromazepam. (8/15)
1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid-brain tryptophan hydroxylase by 36% and 39%, respectively. The concentration of tryptophan was also enhanced in the mid-brain region of rats subjected to benzodiazepine treatment.2 Chronic therapy with either of the two anti-anxiety agents enhanced the endogenous levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in cerebral cortex, hypothalamus, pons-medulla, mid-brain and striatum.3 Whereas diazepam treatment decreased (13%) the activity of monoamine oxidase in mid-brain, bromazepam failed to exert any effect, suggesting that the observed elevation in 5-hydroxy-indoleacetic acid levels is not associated with enhanced deamination of 5-hydroxytryptamine.4 Discontinuation of treatment for 48 h significantly decreased the activity of mid-brain tryptophan hydroxylase to levels that were significantly lower than those seen for benzodiazepine-treated and normal rats. The concentrations of mid-brain tryptophan and 5-hydroxytryptamine were also reduced in various brain regions examined.5 Withdrawal from diazepam or bromazepam therapy further augmented the levels of brain 5-hydroxyindoleacetic acid.6 The results demonstrate that the depressant effects on behaviour of these agents are accompanied by increased metabolism of 5-hydroxytryptamine in the brain. Withdrawal from these minor tranquillizers, on the other hand, reduces the synthesis of this indoleamine. (+info)
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Benzodiazepine: Adinazolam • Alprazolam • Bromazepam • Camazepam • Clordiazepoxid • Clobazam • Clonazepam • Clorazepat • ... Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): A comparative study". Arquivos de ...
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Lexotanil17
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- Lexotanil (Bromazepam) Bromazepam is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. (blessedpharmacy.com)
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- Bromazepam (Lexotanil) 3mg bitartrate and acetaminophen are supplied in tablet form for oral administration. (jasonscottmedical.com)
- Bromazepam (Lexotanil) is in the group of drugs known as benzodiazepines, a class of antidepressants, anti-panic agents, and muscle relaxants. (goodmedspharmacy.com)
- Buy Bromazepam 6mg Online for sale (marketed under several brand names, including lectopam, lexotan, lexilium, lexaurin, brazepam, rekotnil, bromaze and lexotanil) is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. (goodmedspharmacy.com)
- BROMAZEPAM lexotanil 3 mg (marketed under several brand names, including Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze, Somalium and Lexotanil) is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s.It has mainly an anti-anxiety agent with similar side effects to diazepam (Valium). (mypharmworld.com)
- What is Bromazepam lexotanil 3 mg used for? (mypharmworld.com)
- Lexotanil (Bromazepam) is useful for the short-term, symptomatic relief of manifestations of excessive anxiety in patients with anxiety neurosis. (eurdoc.com)
- Lexotanil (Bromazepam) is contra-indicated in-patients with known hypersensitivity to benzodiazepines, myasthenia gravis, severe hepatic insufficiency, severe respiratory insufficiency or sleep apnea syndrome. (eurdoc.com)
- Lexotanil (Bromazepam) is not recommended for use in patients with depressive disorders or psychosis. (eurdoc.com)
- Lexotanil (also known as Bromazepam) side effects are usually temporary, and fade with continued treatment. (macromass.cn)
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Lexotan9
- Bromazepam (lexotan) medical information and frequently asked questions about quitting or discontinuing bromazepam. (hajixuk.ru)
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- Stages of withdrawal can be divided into the early withdrawal phase, acute withdrawal, and postacute withdrawal.Lexotan (bromazepam) 1. (hajixuk.ru)
- i don't get withdrawals as bad as some people, i get it worse than some people.Bromazepam (lexotan) medical information and frequently asked questions about quitting or discontinuing bromazepam. (hajixuk.ru)
- Bromazepam (marketed under several brand names, including lectopam, lexotan, lexilium, lexaurin, brazepam, bromaze, and l.Bromazepam is a type of benzodiazepine medication that is used to treat anxiety and insomnia as well as seizure disorders, muscle.During withdrawal of bromazepam or diazepam a fall in tryptophan, serotonin levels efficacy and withdrawal of two potent benzodiazepines: bromazepam and lorazepam.Instruction for use: bromazepam. (hajixuk.ru)
- lexotan 1.5 bromazepam, mogadon kaufen , bromazepam 1 mg? (skinchat.net)
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- Bromazepam (also known as Lexotan®) is known as a benzodiazepine. (mypharmworld.com)
- Lexotan contains the active ingredient bromazepam. (nps.org.au)
Benzodiazepines9
- Bromazepam shares with other benzodiazepines the risk of abuse, misuse, psychological and/or physical dependence. (bionity.com)
- According to many psychiatric experts Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action. (bionity.com)
- Bromazepam belongs to the class of mediations known as benzodiazepines . (canada.com)
- Benzodiazepines, such as bromazepam, have been used in the pharmacological treatment of anxiety since the early 60's 1 . (scielo.br)
- Despite the vast number of vigilance studies that employed benzodiazepines, few have employed bromazepam and ERP measures 9 . (scielo.br)
- During withdrawal of bromazepam or diazepam a fall in tryptophan, serotonin levels efficacy and withdrawal of two potent benzodiazepines: bromazepam and lorazepam. (hajixuk.ru)
- new spectrophotometric and fluorimetric methods have been developed to determine diazepam, bromazepam and clonazepam (1,4-benzodiazepines) in pure forms, pharmaceutical preparations and biological fluid. (page.tl)
- Alle medisch belangrijke benzodiazepines hebben een 5-aryl substituent en een 1,4 diazepine ring. (scribd.com)
- De benzodiazepines bestaan uit het basisskelet van deze dringen, en verschillen van elkaar qua substituenten. (scribd.com)
Lectopam1
- Bromazepam is also available in Canada as Lectopam. (bionity.com)
Tablets2
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Active ingredient1
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Calmepam1
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Lexaurin1
- Lexaurin (Bromazepam) 1.5mg has to be stored at a room temperature of not more than 77 degrees F, equivalent to 25 degrees C. It should also be placed in a container which is tightly-closed and without humidity. (farmacienow.net)
Stop taking bro2
- If you have been taking this medication regularly for a long time (i.e., longer than a month), do not stop taking bromazepam without first speaking to your doctor. (canada.com)
- Can I stop taking bromazepam suddenly? (mypharmworld.com)
Effect of bromazepam1
- Drug withdrawal catatonia has been described as an effect of bromazepam withdrawal (5a). (hajixuk.ru)
Effects of bromazepam4
- Specifically, the effects of bromazepam (3mg) on the P300 component of the ERP were tested in a double-blind experiment. (scielo.br)
- Results suggest that the effects of bromazepam (3mg) on cognitive processes are not apparent. (scielo.br)
- The present study aimed at investigating the modulatory effects of bromazepam on brain dynamics. (drugs-forum.com)
- The effects of bromazepam (3 mg) on EEG power distribution were tested in 10 healthy individuals, in a double-blind experiment. (drugs-forum.com)
Pharma1
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Pharmacie en ligne1
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Medication4
- Bromazepam is normally used for a short period of time or as an 'as required' medication. (canada.com)
- Bromazepam is a medication marketed under different names, such as Lexomil. (ccm.net)
- Bromazepam is a type of benzodiazepine medication that is used to treat anxiety and insomnia as well as seizure disorders, muscle. (hajixuk.ru)
- Prolonged use of bromazepam causes tolerance and may lead to both physical and psychological dependence on the drug, and as a result, it is a medication which is controlled by international law. (legitrxscript.com)
Clonazepam5
- on a mg to mg basis the 2 mg clonazepam is more potent than the 1.5 mg bromazepam . (drugs-forum.com)
- I have tried both and thinks that bromazepam may have more recreational value than clonazepam , and has a more powerful kick. (drugs-forum.com)
- I agree that recreational value is higher with bromazepam - clonazepam is a good med for preventing panics, seizures etc, but bromazepam can give a sense of euphoria at a dosage of 12mg, which is like 30mg diazepam . (drugs-forum.com)
- Bromazepam undergoes hepatic microsomal oxidation 257 and is eliminated primarily as epilepsy or seizures, history of (initiation or abrupt withdrawal of clonazepam or. (hajixuk.ru)
- clonazepam bromazepam 2 mg. bromazepam in bangladesh, bromazepam tabletten. (skinchat.net)
Lorazepam1
- Bromazepam lorazepam has been prescribed cranberry juice xanax, 2015 this class. (buydiflucancvv.com)
Sedative1
- Bromazepam is an anti-anxiety treatment and a sedative. (linkpharma.org)
Potencial evocado3
- No entanto, poucos estudos têm combinado bromazepam e potencial evocado relacionado a evento (PRE). (scielo.br)
- bromazepam, potencial evocado relacionado a evento, P300. (scielo.br)
- Comparar os efeitos neuromoduladores da cafeína e do bromazepam a partir do banco normativo do potencial evocado visual (P300). (bvsalud.org)
Lexomil1
- Bromazepam is available in Yemen as Novepam and in Cambodia as Lexomil. (bionity.com)
Diazepam6
- A 3mg dose of bromazepam is equivalent to a 5mg dose of diazepam . (bionity.com)
- 1,5mg bromazepam is like 2mg diazepam - strong enough for really old people is all. (drugs-forum.com)
- Note: 6mg of bromazepam is approximately equivelant to 10mg diazepam. (hajixuk.ru)
- bromazepam 56mg's ~=10mg diazepam. (hajixuk.ru)
- Benzodiazepine name voor de stoffen die nordazepam als metaboliet hebben: zoals bijvoorbeeld chloordiazepoxide, clorazepinezuur, diazepam, ketazolam, medazepam en prazepam. (scribd.com)
- Bij regelmatige inname kan de halfwaardetijd oplopen tot wel 75-100 uur bij diazepam en vergelijkbare benzodiazepinen. (scribd.com)
Koop1
- posologie bromazepam, bromazepam te koop gevraagd. (skinchat.net)
Actavis1
- Bromazepam Actavis may be available in the countries listed below. (legitrxscript.com)
Resultados sugerem2
- Os resultados sugerem que os efeitos de 3mg de bromazepam em processos cognitivos não são aparentes. (scielo.br)
- Os resultados sugerem que a cafeína e o bromazepam têm efeitos moduladores específicos no SNC . (bvsalud.org)
Efeitos2
Dose5
- The recommended starting dose of bromazepam for adults ranges from 6 mg to 18 mg daily, in divided doses. (canada.com)
- You will be guaranteed a good night after a decent dose of bromazepam . (drugs-forum.com)
- venta de bromazepam, bromazepam recommended dose. (skinchat.net)
- What is the usual dose of bromazepam? (mypharmworld.com)
- The usual dose of bromazepam in adults for anxiety is 3-18mg a day a day, usually split up throughout the day. (mypharmworld.com)
Foram3
- Medidas eletrofisiológicas (P300) e comportamentais (stroop, digit span, e tempo de reação) foram analisadas em três condições experimentais: placebo 1, placebo 2 e bromazepam. (scielo.br)
- Os sujeitos foram submetidos a uma tarefa de discriminação visual utilizando o paradigma "oddball", após a administração de uma cápsula de cafeína ou de bromazepam , em um desenho duplo-cego randomizado. (bvsalud.org)
- Foram observadas diferenças estatisticamente significativas quando as condições cafeína e bromazepam foram comparadas com o banco normativo. (bvsalud.org)
Substance2
- The latin name of the substance bromazepam. (hajixuk.ru)
- Bromazepam is contraindicated and should be used with caution in women who are pregnant, the elderly, patients with a history of alcohol or other substance abuse disorders and children. (legitrxscript.com)
Anxiety5
- Acute myocardial infarction (AMI): state anxiety, stress hormone response and clinical course in patients treated and not treated with bromazepam. (umn.edu)
- Bromazepam is a benzodiazepine drug prescribed for shortterm bromazepam relieves fear and anxiety and acts as a tranquilizing agent in general. (hajixuk.ru)
- bromazepam 1 5 opiniones, bromazepam lannacher 3 mg, .5 mg ativan for anxiety . (skinchat.net)
- In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. (farmacienow.net)
- Bromazepam is usually used as a short term treatment for major anxiety, but is not recommended for use to relieve everyday stress or anxiety. (linkpharma.org)
Tafil1
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Romania1
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Hepatic1
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Drugs-Forum1
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Alcohol3
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- Can I drink alcohol while I am taking bromazepam? (mypharmworld.com)
Chemical2
- We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. (beds.ac.uk)
- This is the first case in literature that shows a chemical gastritis after bromazepam intake. (beds.ac.uk)
Placebo1
- Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. (scielo.br)
Undergoes1
- Quantitative study of an acid hydrolysis of bromazepam, which in acidic solution simultaneously undergoes reversible 4,5-azomethine bond cleavage and protolytic reactions, was performed (t = 25degreesC). (ac.rs)
Dosage1
- a 51yearold man who had been taking bromazepam for 9 years in a dosage that. (hajixuk.ru)
Omeprazole1
- Development and validation of an HPLC method for the simultaneous monitoring of bromazepam and omeprazole. (chuv.ch)