A fibrinolytic and thrombolytic enzyme from Aspergillus oryzae. EC 3.4.99.-.

The enhancing influence of proteolysis on E rosette forming lymphocytes (T cells) in vivo and in vitro. (1/1)

The T lymphocytes populations of 22 young healthy adults, 21 healthy middle aged and older blood donors, 35 non-pregnant women of child bearing age and 14 patients with advanced malignant disease were assessed and compared. It was found that the mean T cell counts in the middle aged and older controls were significantly lower than in the healthy young adults and were further reduced in the patients with malignant disease. The addition of the proteolytic agent brinase (protease 1 obtained from Aspergillus oryzae) to the rosetting test increased the T cell counts signficantly in all groups. This was mot marked in the older age groups and the patients with malignant disease. The proteolytic agent is shown to exert its effect on the lymphocytes in the test. Slow intravenous infusion of either brinase or streptokinase into patients with malignant disease is shown to result in increased T lymphocyte counts pari passu with a restoration of skin allergy. The significance of these findings and possible mode of action of the proteolytic agents in increasing T cell activity are discussed.  (+info)

I am not aware of a medical definition for "Brinolase." It is possible that this term may be used in a specific research or clinical context, but I was unable to find any information about it in the widely recognized medical resources. If you could provide more context or clarify what you are looking for, I would be happy to help further.

Brinolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, ... Brinase (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug. It is derived from Aspergillus oryzae. Aspergillus ...
... brinolase MeSH D08.811.277.656.300.133 - cathepsins MeSH D08.811.277.656.300.133.062 - carboxypeptidase c MeSH D08.811.277.656. ...
Brinolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, ... Brinase (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug. It is derived from Aspergillus oryzae. Aspergillus ...
Brinolase [D08.811.277.656.300.099] Brinolase * Coagulase [D08.811.277.656.300.174] Coagulase * Cysteine Endopeptidases [ ...
BRINOLASE (UNII: Z3GVO2327F) (ASPERGILLUS FLAVUS VAR. ORYZAE PROTEASE - UNII:Z3GVO2327F) BRINOLASE. 9 [hp_X] in 1 mL. ...
Brinolase Preferred Term Term UI T005564. Date01/01/1999. LexicalTag NON. ThesaurusID USAN (1971). ... Brinolase Preferred Concept UI. M0002923. Registry Number. EC 3.4.99.-. Scope Note. A fibrinolytic and thrombolytic enzyme from ... Brinolase. Tree Number(s). D08.811.277.656.300.099. Unique ID. D001954. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Brinolase Preferred Term Term UI T005564. Date01/01/1999. LexicalTag NON. ThesaurusID USAN (1971). ... Brinolase Preferred Concept UI. M0002923. Registry Number. EC 3.4.99.-. Scope Note. A fibrinolytic and thrombolytic enzyme from ... Brinolase. Tree Number(s). D08.811.277.656.300.099. Unique ID. D001954. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Brinolase (0) * Coagulase (0) * Cysteine Endopeptidases (0) * Metalloendopeptidases (0) * Serine Endopeptidases (0) ...
TARTRATE C47419 UC0DRK4OE0 BRINAZARONE C72623 6794O900AX BRINCIDOFOVIR C90587 5CA81DKM2L BRINDOXIME C78094 Z3GVO2327F BRINOLASE ...
Hull, D. S., Bowman, K. , and Green, K. : Effect of brinolase on corneal endothelium. Canad. J. Ophthal . 11: 82, 1976. 67. ...
HYDROLASES BRINOLASE HYDROLASES BROMELAINS HYDROLASES BUTYRYLCHOLINESTERASE HYDROLASES CA(2+) MG(2+)-ATPASE HYDROLASES CA(2+)- ... HEMATOLOGIC AGENTS BRINOLASE HEMATOLOGIC AGENTS CALCIUM DOBESILATE HEMATOLOGIC AGENTS CELLULOSE, OXIDIZED HEMATOLOGIC AGENTS ... AND RENA BRINOLASE HEMATOLOGIC, GASTROINTESTINAL, AND RENA BUMETANIDE HEMATOLOGIC, GASTROINTESTINAL, AND RENA BURIMAMIDE ... FIBRINOLYTIC AGENTS BRINOLASE FIBRINOLYTIC AGENTS ENOXAPARIN FIBRINOLYTIC AGENTS FIBRINOLYTIC AGENTS FIBRINOLYTIC AGENTS ...
Brinolase [D08.811.277.656.300.099] Brinolase * Coagulase [D08.811.277.656.300.174] Coagulase * Cysteine Endopeptidases [ ...

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