The enhancing influence of proteolysis on E rosette forming lymphocytes (T cells) in vivo and in vitro. (1/1)

The T lymphocytes populations of 22 young healthy adults, 21 healthy middle aged and older blood donors, 35 non-pregnant women of child bearing age and 14 patients with advanced malignant disease were assessed and compared. It was found that the mean T cell counts in the middle aged and older controls were significantly lower than in the healthy young adults and were further reduced in the patients with malignant disease. The addition of the proteolytic agent brinase (protease 1 obtained from Aspergillus oryzae) to the rosetting test increased the T cell counts signficantly in all groups. This was mot marked in the older age groups and the patients with malignant disease. The proteolytic agent is shown to exert its effect on the lymphocytes in the test. Slow intravenous infusion of either brinase or streptokinase into patients with malignant disease is shown to result in increased T lymphocyte counts pari passu with a restoration of skin allergy. The significance of these findings and possible mode of action of the proteolytic agents in increasing T cell activity are discussed.  (+info)

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... (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug. It is derived from Aspergillus oryzae. Aspergillus ... Brinolase at the US National Library of Medicine Medical Subject Headings (MeSH). ...
... brinolase MeSH D08.811.277.656.300.133 --- cathepsins MeSH D08.811.277.656.300.133.062 --- carboxypeptidase c MeSH D08.811. ...
Brinolase *Coagulase *Metalloendopeptidases + *Serine Endopeptidases + *Streptokinase + *Exopeptidases *Aminopeptidases + * ...
"Brinolase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Brinolase" by people in this website by year, and whether " ... Below are the most recent publications written about "Brinolase" by people in Profiles. ...
Brinase (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug. It is derived from Aspergillus oryzae. Aspergillus ... Brinolase at the US National Library of Medicine Medical Subject Headings (MeSH). ...
... brinolase MeSH D08.811.277.656.300.133 --- cathepsins MeSH D08.811.277.656.300.133.062 --- carboxypeptidase c MeSH D08.811. ...
Brinolase *Coagulase *Metalloendopeptidases � + *Serine Endopeptidases � + *Streptokinase � + *Exopeptidases *Aminopeptidases ...
This graph shows the total number of publications written about "ATP-Dependent Endopeptidases" by people in this website by year, and whether "ATP-Dependent Endopeptidases" was a major or minor topic of these publications ...
Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen ...
... brinolase, Hageman factor (i.e. factor XII) fragments, plasminogen activators such as, for example, streptokinase, tissue ...
Brinolase. *Brinsley Animal Rescue. *Brinsmead Ziola Kennedy Architecture. *Brinson Partners Global Security Market Index ...
Serine Endopeptidases, are any member of the group of Endopeptidases as serine proteases, containing at the active site a Serine residue involved in catalysis.
Nonassimilatory apologiser marginating round it shelvers brinolase. Carbidopa/ Levodopa/ Entacapone is used in the buy ...