Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Rhinoplasty: A plastic surgical operation on the nose, either reconstructive, restorative, or cosmetic. (Dorland, 28th ed)Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Brevican: A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and in experimental models of GLIOMA.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Hyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.New YorkStudents: Individuals enrolled in a school or formal educational program.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Students, Medical: Individuals enrolled in a school of medicine or a formal educational program in medicine.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Receptors, N-Acetylglucosamine: Cell surface receptors that bind to ACETYLGLUCOSAMINE.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Mild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Behavior, Animal: The observable response an animal makes to any situation.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Aspergillus oryzae: An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.Mice, Neurologic Mutants: Mice which carry mutant genes for neurologic defects or abnormalities.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Cell Adhesion: Adherence of cells to surfaces or to other cells.Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Chondroitin ABC Lyase: An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Chondroitin Lyases: Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.Heparitin Sulfate: A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.

The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion. (1/43)

The lecticans are a group of chondroitin sulfate proteoglycans characterized by the presence of C-type lectin domains. Despite the suggestion that their lectin domains interact with carbohydrate ligands, the identity of such ligands has not been elucidated. We previously showed that brevican, a nervous system-specific lectican, binds the surface of B28 glial cells (Yamada, H., Fredette, B., Shitara, K., Hagihara, K., Miura, R., Ranscht, B., Stallcup, W. B., and Yamaguchi, Y. (1997) J. Neurosci. 17, 7784-7795). In this paper, we demonstrate that two classes of sulfated glycolipids, sulfatides and HNK-1-reactive sulfoglucuronylglycolipids (SGGLs), act as cell surface receptors for brevican. The lectin domain of brevican binds sulfatides and SGGLs in a calcium-dependent manner as expected of a C-type lectin domain. Intact, full-length brevican also binds both sulfatides and SGGLs. The lectin domain immobilized as a substrate supports adhesion of cells expressing SGGLs or sulfatides, which was inhibited by monoclonal antibodies against these glycolipids or by treatment of the substrate with SGGLs or sulfatides. Our findings demonstrate that the interaction between the lectin domains of lecticans and sulfated glycolipids comprises a novel cell substrate recognition system, and suggest that lecticans in extracellular matrices serve as substrate for adhesion and migration of cells expressing these glycolipids in vivo.  (+info)

Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans. (2/43)

The absence of fiber regrowth in the injured mammalian CNS is influenced by several different factors and mechanisms. Besides the nonconducive properties of the glial scar tissue that forms around the lesion site, individual molecules present in CNS myelin and expressed by oligodendrocytes, such as NI-35/NI-250, bNI-220, and myelin-associated glycoprotein (MAG), have been isolated and shown to inhibit axonal growth. Here, we report an additional neurite growth-inhibitory activity purified from bovine spinal cord myelin that is not related to bNI-220 or MAG. This activity can be ascribed to the presence of two chondroitin sulfate proteoglycans (CSPGs), brevican and the brain-specific versican V2 splice variant. Neurite outgrowth of neonatal cerebellar granule cells and of dorsal root ganglion neurons in vitro was strongly inhibited by this myelin fraction enriched in CSPGs. Immunohistochemical staining revealed that brevican and versican V2 are present on the surfaces of differentiated oligodendrocytes. We provide evidence that treatment of oligodendrocytes with the proteoglycan synthesis inhibitors beta-xylosides can strongly influence the growth permissiveness of oligodendrocytes. beta-Xylosides abolished cell surface presentation of brevican and versican V2 and reversed growth cone collapse in encounters with oligodendrocytes as demonstrated by time-lapse video microscopy. Instead, growth cones were able to grow along or even into the processes of oligodendrocytes. Our results strongly suggest that brevican and versican V2 are additional components of CNS myelin that contribute to its nonpermissive substrate properties for axonal growth. Expression of these CSPGs on oligodendrocytes may indicate that they participate in the restriction of structural plasticity and regeneration in the adult CNS.  (+info)

The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. (3/43)

Chondroitin sulfate proteoglycans (CS-PGs) expressed by reactive astrocytes may contribute to the axon growth-inhibitory environment of the injured CNS. The specific potentially inhibitory CS-PGs present in areas of reactive gliosis, however, have yet to be thoroughly examined. In this study, we used immunohistochemistry, combined immunohistochemistry-in situ hybridization, immunoblot analysis, and reverse transcription-PCR to examine the expression of specific CS-PGs by reactive astrocytes in an in vivo model of reactive gliosis: that is, the glial scar, after cortical injury. Neurocan and phosphacan can be localized to reactive astrocytes 30 d after CNS injury, whereas brevican and versican are not expressed in the chronic glial scar. Neurocan is also expressed by astrocytes in primary cell culture. Relative to the amount present in cultured astrocytes or uninjured cortex, neurocan expression increases significantly in the glial scar resulting from cortical injury, including the re-expression of the neonatal isoform of neurocan. In contrast, phosphacan protein levels are decreased in the glial scar compared with the uninjured brain. Because these CS-PGs are capable of inhibiting neurite outgrowth in vitro, our data suggest that phosphacan and neurocan in areas of reactive gliosis may contribute to axonal regenerative failure after CNS injury.  (+info)

A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells. (4/43)

Selectins bind to carbohydrate ligands in a calcium-dependent manner and play critical roles in host defense and possibly in tumor metastasis. To isolate peptides that mimic E-selectin ligands, we screened a phage peptide library using E-selectin as a target molecule. This attempt unexpectedly failed, probably because the binding affinity of E-selectin to its ligand is low. We then took an approach that is analogous to the isolation of anti-idiotype antibodies and were able to isolate peptides that bound to anticarbohydrate antibodies recognizing E-selectin ligands. These peptides, enriched for their binding to anti-Lewis A antibody, were found to bind to E-, P- and L-selectins in a calcium-dependent manner. Phage harboring the identified peptide IELLQAR and synthetic peptides having the same sequence inhibited the binding of sialyl Lewis X or sialyl Lewis A oligosaccharides to E-selectin. The adhesion of HL-60 and B16 melanoma cells expressing sialyl Lewis X to E-selectin was also inhibited by the phage-displaying IELLQAR peptide. Moreover, i.v. injected IELLQAR peptide inhibited the lung colonization of mouse B16 melanoma and human lung tumor cells expressing sialyl Lewis X. These results demonstrate that it is possible to isolate peptides mimicking carbohydrate ligands by screening the peptides for binding to anticarbohydrate antibodies and then using them to inhibit carbohydrate-dependent experimental tumor metastasis.  (+info)

Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. (5/43)

Brain-enriched hyaluronan binding (BEHAB)/brevican is a brain-specific extracellular matrix protein containing a cleavage site between Glu(395)-Ser(396), which bears remarkable homology to the "aggrecanase" site in the cartilage proteoglycan aggrecan. Expression of BEHAB/brevican is dramatically increased in human gliomas, notoriously invasive tumors. Recently, we showed that the rat 9L gliosarcoma cell line, which does not express BEHAB/brevican and forms non-invasive tumors when grown as intracranial grafts, can form invasive tumors when transfected with a 5' cDNA fragment of BEHAB/brevican, but not when transfected with the full-length cDNA. In marked contrast, the highly invasive CNS-1 glioma cell line expresses and cleaves BEHAB/brevican protein when grown as an intracranial graft. These results suggest that both synthesis and cleavage of BEHAB/brevican protein may play a role in the invasiveness of gliomas. We report here, using an antibody developed to the neoepitope created by BEHAB/brevican cleavage at the Glu(395)-Ser(396) site, that the CNS-1 cells are able to cleave the protein in vitro. We characterized the CNS-1-derived cleavage activity by assaying its ability to cleave BEHAB/brevican proteoglycan, and determined that the enzyme is a constitutively expressed, secreted activity. Using a variety of protease inhibitors, reverse transcriptase-polymerase chain reaction, and specific antibodies, we determined that this activity is likely to be a member of the ADAMTS family of metalloproteinases, specifically ADAMTS4. These results suggest a novel function for ADAMTS family members in BEHAB/brevican cleavage and glioma and indicate that inhibition of ADAMTS in glioma may provide a novel therapeutic strategy.  (+info)

Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. (6/43)

Brevican is a member of the lectican family of chondroitin sulfate proteoglycans that is predominantly expressed in the central nervous system. The susceptibility of brevican to digestion by matrix metalloproteinases (MMP-1, -2, -3, -7, -8, -9, -10, and -13 and membrane type 1 and 3 MMPs) and aggrecanase-1 (ADAMTS4) was examined. MMP-1, -2, -3, -7, -8, -10, and -13 degraded brevican into a few fragments with similar molecular masses, whereas the degradation products of aggrecanase-1 had apparently different sizes. NH(2)-terminal sequence analyses of the digestion fragments revealed that cleavages of the brevican core protein by these metalloproteinases occurred commonly within the central non-homologous domain. MMP-1, -2, -3, -7, -8, -10, and -13 preferentially attacked the Ala(360)-Phe(361) bond, whereas aggrecanase-1 cleaved the Glu(395)-Ser(396) bond, which are similar to the cleavage sites observed with cartilage proteoglycan (aggrecan) for the MMPs and aggrecanase-1, respectively. These data demonstrate that MMP-1, -2, -3, -7, -8, -10, and -13 and aggrecanase-1 digest brevican in a similar pattern to aggrecan and suggest that they may be responsible for the physiological turnover and pathological degradation of brevican.  (+info)

Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. (7/43)

A complete cDNA encoding the Xenopus laevis homologue of the aggrecan/versican family member, brevican (Xbcan) was cloned from an embryonic stage 42 cDNA library. In the deduced amino acid sequence, 1152 in length, similarity to the hyaluronan-binding (link) domains of brevicans from other species were present in the N-terminal region as well as EGF-, lectin- and complement regulatory protein-like domains in the C-terminal part, the latter three being characteristic for brevican found within the extracellular matrix (J. Biol. Chem. 269 (1994) 10119). Indeed, Xbcan was secreted into the extracellular space as a soluble protein when expressed in oocytes. No cDNAs encoding a GPI-anchored bcan variant could be isolated from that cDNA library. During embryonic development, the expression of this gene was first observed in the notochord of neurula stage embryos. In addition to this, in tailbuds, Xbcan was also found to be expressed within the fifth and sixth rhombomere of the hindbrain. In tadpole stage embryos, expression was furthermore observed in periventricular regions of the developing brain and the rostral part of the spinal cord.  (+info)

Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury. (8/43)

Aggrecan is a large proteoglycan (PG) that has been grouped with different PG families on the basis of its physical characteristics. These families include the chondroitin sulfate PGs, which appear to inhibit the migration of cells and axons during development. Although aggrecan has been studied primarily in cartilage, in the present study, tissue samples from developing, mature, and injured-adult rat spinal cords were used to determine whether aggrecan is present in the mammalian spinal cord. By the use of Western blot analysis, tissues were probed with aggrecan-specific antibodies (ATEGQV, TYKHRL, and LEC-7) and aggrecan-specific neoepitope antibodies (NITEGE, FVDIPEN, and TFKEEE) to identify full-length aggrecan and several fragments. Unlike many other aggrecan gene family members, aggrecan species were similar in embryonic day 14, postnatal day 1, and adult spinal cords. Spinal cord injury caused significant decreases in aggrecan. Partial recovery in some aggrecan species was evident by 2 weeks after injury. The presence of specific aggrecan neoepitopes suggested that aggrecan is cleaved in the spinal cord by both a disintegrin and metalloproteinase thrombospondin (also known as aggrecanase) and metalloproteinase-like activities. Many aggrecan species found in the spinal cord were similar to species in cartilage. Additional antibodies were used to identify two other aggrecan gene family members, neurocan and brevican, in the adult spinal cord. These studies present novel information on the aggrecan core protein species and enzymes involved in aggrecan cleavage in vivo in the rat spinal cord throughout development and after injury. They also provide the basis for investigating the function of aggrecan in the spinal cord.  (+info)

*Brevican

... core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein ... "Entrez Gene: BCAN brevican". Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic ... Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat ... Brevican is localised to the surface of neurons in the brain. In melanocytic cells, BCAN gene expression may be regulated by ...

*ADAMTS5

"Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239-46. doi:10.1007/s00401- ...

*HAPLN2

Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix ...

*Lectican

The expression of neurocan and brevican is largely restricted to neural tissues. All four lecticans contain an N-terminal ... There are four members of the lectican family: aggrecan, brevican, neurocan, and versican. Lecticans interact with hyaluronic ...

*Perineuronal net

The CSPGs aggrecan, versican, neurocan, brevican, and phosphacan are bound to hyaluronan. PNNs found in both the brain and the ... Following seizures, there is a decrease in phosphacan and phosphacan-positive PNNs and an increase in cleaved brevican in the ... In the rat brain and spinal cord, the expression of various CSPGs (brevican, versican, neurocan, and NG2) increases after ... PNNs are composed of brevican, neurocan, versican, aggrecan, phosphacan, hyaluronan, tenascin-R and various link proteins. ...

*ADAMTS4

Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded ... The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system ... It can degrade aggrecan, a major proteoglycan of cartilage, brevican, a brain-specific extracellular matrix protein, neurocan ... brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) ...

*Matrix metallopeptidase 13

2001). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". J. Biol. Chem. 275 ( ...

*Chondroitin sulfate proteoglycan

Brevican (CSPG7) CD44 (CSPG8, cluster of differentiation 44) Phosphacan Neurocan, brevican, versican, and aggrecan all share ... Neurocan, brevican, and versican levels are up-regulated as early as one day post injury, and all of these levels peak at 2 ... Jones, L. L.; Margolis, R. U.; Tuszynski, M. H. (2003). "The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, ... brevican, phosphacan, and versican) levels before spinal cord injury and after spinal cord injury indicate that there is a ...

*Glial scar

Jones LL, Margolis RU, Tuszynski MH (August 2003). "The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and ...

*Versican

... belongs to the lectican protein family, with aggrecan (abundant in cartilage), brevican and neurocan (nervous system ...

*Aggrecan

The aggrecan family includes other important members such as versican, also named PG-M, neurocan, brevican and the cell surface ...

*Link domain

... brevican, neurocan and versican, which are expressed in the CNS; the cartilage link protein (LP), a proteoglycan that together ...

*ADAMTS

... brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have ...
We show here that, within the brain, invasive ability can be conferred on a noninvasive glioma cell line by expression of an N-terminal fragment of the BEHAB/brevican protein but not by expression of the full-length protein. Because partial proteolytic cleavage of the BEHAB/brevican protein occurs endogenously in both human and rodent invasive brain tumors, these results provide an explanation for glioma cell motility in the adult human brain. In addition, they suggest new therapeutic possibilities for human brain tumor.. Many studies have suggested a central role for extracellular matrix proteins in tumor growth and motility (Paulus et al., 1996; Haugland et al., 1997; Merzak and Pilkington, 1997). HA and HA-binding proteins have been implicated in tumor metastasis (Knudson and Knudson, 1993;Entwistle et al., 1996). For example, the HA-binding protein RHAMM increases the metastatic potential of fibroblast cell lines (Hall et al., 1995). Our present results provide evidence that expression of ...
BCAN Antibody (C-term), Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) validated in WB, IHC-P, FC, E (AP5915b), Abgent
The HealthWell Foundation®, an independent non-profit that provides a financial lifeline for inadequately insured Americans, has opened a new fund to provide copayment and premium assistance to eligible Medicare patients living with bladder or urothelial cancer. Through the fund, HealthWell will provide up to $5,000 in assistance to Medicare patients who have annual household incomes up to 400 percent of the federal poverty level. The new fund will assist these patients in accessing critical medications for treatment of their disease.. ...
모체의 혈청 내 호모시스테인 수준은 태아 성장에 중요한 요인으로 부각되고 있으며 영아의 정상적인 발달과 성장을 위하여 비타민 B₂, 비타민 B_(6), 엽산, 비타민 B_(12) 영양상태가 중요한 것으로 알려져 왔다. 본 연구에서는 생후 12개월 영아의 성장에 관련성이 있을 것이라 사료되는 모체의 임신 중반기의 혈청 호모시스테인 수치와 혈청 비타민 B군 수준, 영아의 비타민 B군 섭취상태에 따른 영아의 성장 발달을 살펴보았다. 또한 영아의 수유상황과 보충제 복용유무, 질병실태에 따른 영아의 영양섭취상태와 성장을 살펴보았다. 이 연구는 전향적 코호트 연구로서 기존에 E 대학 병원 산부인과에서 임신 24-28주의 임산부 308명을 대상으로 이루어졌다. 이들에게서 태어난 영아들 중 생후 1년째의 영아 110명을 대상으로 신체 계측을 실시하고, 식이섭취조사와 ...
Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene. HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain. Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal. GRCh38: Ensembl release 89: ENSG00000132702 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000004894 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". "Entrez Gene: hyaluronan and proteoglycan link protein 2". Bekku Y, Vargová L, Goto Y, Vorísek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fässler R, Ninomiya Y, Syková E, Oohashi T (Feb 2010). "Bral1: its role in diffusion barrier formation and conduction velocity in the CNS". The Journal of Neuroscience. 30 (8): 3113-23. doi:10.1523/JNEUROSCI.5598-09.2010. ...
Continent catheterizable reconstruction: One of a group of internal reservoirs or new bladders (neobladders) that are not attached to the urethra. Instead, it is emptied through catheterization, usually through a special attachment to the skin that is similar to but smaller than the stoma for an ileal conduit. The continent reservoir is formed from a piece of small intestine to hold urine after the bladder has been removed. Continent reconstructions are often referred to by names given to them at the institution where the particular type of reconstruction was developed, examples are Indiana Pouch and Continent Cutaneous Pouch ...
Blog on HAPLN1 cdna clone product: The HAPLN1 hapln1 (Catalog #MBS1270699) is a cDNA Clone and is intended for research purposes only. The p...
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Comparative studies on the distribution of hyaluronidase-sensitive ECM glycosaminoglycans in wild-type and reeler mice suggest a role for HA-associated cues in the formation of neocortical and hippocampal lamination (Derer and Nakanishi, 1983; Nakanishi, 1983). A subset of HA-associated proteoglycans, the chondroitinsulfate (CS) proteoglycans (CSPGs), are distributed with layer specificity in the developing cortex and are colocalized with growing fiber tracts (Pearlman and Sheppard, 1996). Analysis of the distribution of ECM components in the reeler mouse brain indicates an important function of CSPGs in the formation of cortical lamination (Sheppard and Pearlman, 1997). CSPGs were also shown to be involved in cell-cell adhesion and cell substrate adhesion during development (Hernon and Lander, 1990; Faissner and Steindler, 1995; Margolis and Margolis, 1997; Rauch, 1997; Yamada et al., 1997). A number of HA-binding proteoglycans, including aggrecan, versican, neurocan and brevican have been ...
B B B B B B B B B B B B B B B B B B B B B B B B B B B B B A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A ...
Buy our Recombinant Human HAPLN1 protein (denatured). Ab180280 is a full length protein produced in Escherichia coli and has been validated in SDS-PAGE. Abcam…
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The CD44 antigens are transmembrane glycoproteins and members of the hyaladherin family of hyaluronan-binding proteins. Multiple CD44 isoforms have been described, the predominant form being CD44S, a glycoprotein of 85 kDa. CD44 is present on most cells or tissues, but not on platelets, hepatocytes, cardiac muscle, kidney tubular epithelium, testis and skin portions. The human blood group antigens Ina/b reside on CD44. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Monoclonal antibody against neurocan receptor expressed by for use in Immunohistochemistry, Immunoprecipitation, Western Blot against Chicken, Human, Mouse, Rat
Complete information for HAPLN3 gene (Protein Coding), Hyaluronan And Proteoglycan Link Protein 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Alterations in the structure and physiology of interneurons in the prefrontal cortex (PFC) are important factors in the etiopathology of different psychiatric disorders. Among the interneuronal subpopulations, parvalbumin (PV) expressing cells appear to be specially affected. Interestingly, during development and adulthood the connectivity of these interneurons is regulated by the presence of perineuronal nets (PNNs), specialized regions of the extracellular matrix, which are frequently surrounding PV expressing neurons. Previous reports have found anomalies in the density of PNNs in the PFC of schizophrenic patients. However, although some studies have described alterations in PNNs in some extracortical regions of bipolar disorder patients, there are no studies focusing on the prefrontocortical PNNs of bipolar or major depression patients. For this reason, we have analyzed the density of PNNs in post-mortem sections of the dorsolateral PFC (DLPFC) from the Stanley Neuropathology Consortium, which
Glioblastoma multiforme (GBM) are highly infiltrative, aggressive and lethal primary brain tumors in adults that are resistant to conventional treatments. A major clinical obstacle in the treatment of GBMs is the ability of glioma cells to invade the surrounding brain parenchyma, preventing their complete surgical resection. Several studies have shown that invasive glioma stem cells (GSCs) extend beyond the surgically resected regions. These invasive cells are the cause for tumor recurrence and poor prognosis in GBM patients. The molecular and cellular mechanism involved in the regulation of the switch from proliferation to invasion/migration in GBM is poorly understood. We investigated the role of Olig2, a Central Nervous System (CNS) specific transcription factor, in promoting the switch from proliferating to invading glioma cell. Genetically relevant murine glioma model as well as patient-derived glioma stem cells (GSCs) were utilized to identify the effect of Olig2 on glioma invasion. ...
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TY - JOUR. T1 - Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. AU - Kang, Jeong Suk. AU - Oohashi, Toshitaka. AU - Kawakami, Yasuhiko. AU - Bekku, Yoko. AU - Izpisúa Belmonte, Juan Carlos. AU - Ninomiya, Yoshifumi. PY - 2004/3. Y1 - 2004/3. N2 - We report here the isolation and characterization of a cDNA encoding zebrafish dermacan, a novel member of hyaluronan (HA)-binding proteoglycans, which was termed after its characteristic expression in the zebrafish dermal bones. The deduced protein sequence shares the typical modular elements of lecticans. Sequence comparison covering the C-terminal globular domain demonstrated that dermacan shows high homology with zebrafish versican but is distinct from any other identified lecticans. Genomic DNA analysis demonstrated that dermacan and versican were encoded by distinct genes in the zebrafish genome. The expression of dermacan is initiated in the sclerotome and cephalic paraxial mesoderm at 16 h ...
Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. Neurocan is a significant component of the extracellular matrix, and its levels are modulated by a variety of factors, but mice in which the NCAN gene has been knocked out show no easily observable defects in brain development or behavior. However, a genome-wide association study published in 2011 identified Neurocan as a susceptibility factor for bipolar disorder. A more comprehensive study published in 2012 confirmed that association. The 2012 study examined correlations between NCAN alleles and various symptoms of bipolar disorder, and also examined the behavior of NCAN knockout mice. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but ...
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Corroborating previous research, the new study, which was published online in Anticancer Research, found that low pre-treatment serum testosterone predicted poor overall, cancer-specific, and progression-free survival after primary ADT. The median serum testosterone level was 397 ng/dL. The median overall, cancer-specific, and progression-free survival rates were 68.1, 68.9, and 23.2 months, respectively. Men with higher testosterone levels in the second to fourth quartiles showed similar survival ...
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The company is looking to expand the label of Cysview to include its use in the outpatient setting to detect the recurrence of bladder cancer using a flexible cystoscope, the detection of carcinoma in situ (CIS) and the repeat administration of Cysview. The filing is a combination drug-device application, with the KARL STORZ D-LIGHT C PDD Flexible Videoscope System.. "We are delighted to see the FDA expedite the review for this sNDA as it will offer patients improved surveillance of their Non-Muscle Invasive Bladder Cancer (NMIBC)," commented Andrea Maddox-Smith CEO, Bladder Cancer Advocacy Network (BCAN). BCAN is the only national advocacy organization devoted to advancing bladder cancer research and supporting those impacted by the disease.. "We look forward to hearing a decision from the FDA early next year on the US Cysview® label expansion to include patients undergoing surveillance cystoscopy using a flexible scope. The sNDA also includes detection of CIS and to allow for repeated use in ...
In the rodent model of temporal lobe epilepsy, there is extensive synaptic reorganization within the hippocampus following a single prolonged seizure event, after which animals eventually develop epilepsy. The perineuronal net (PN), a component of the neural extracellular matrix (ECM), primarily surrounds inhibitory interneurons and, under normal conditions, restricts synaptic reorganization. The objective of the current study was to explore the effects of status epilepticus (SE) on PNs in the adult hippocampus. The aggrecan component of the PN was studied, acutely (48 h post-SE), sub-acutely (1 week post-SE) and during the chronic period (2 months post-SE). Aggrecan expressing PNs decreased by 1 week, likely contributing to a permissive environment for neuronal reorganization, and remained attenuated at 2 months. The SE-exposed hippocampus showed many PNs with poor structural integrity, a condition rarely seen in controls. Additionally, the decrease in the aggrecan component of the PN was ...
OPC bold driver CC grad. desc. CC bold driver ECOC BCH grad. desc. ECOC BCH bold driver (a) (b) Figure 1: Comparison of performances of different decomposition methods on glass (a) and optdigits (b) data sets of the UCI. Table 4: Standard PWC (left) and CC (right) decomposition matrices. 0 B B B B B @ +1 1 0 0 +1 0 1 0 +1 0 0 1 0 +1 1 0 0 +1 0 1 0 0 +1 1 1 C C C C C A 0 B B B B B @ +1 +1 1 1 +1 1 +1 ...
This work is supported by NSF grant nos. IIS-0612049, CNS-0916908 and CNS-0615277, a grant from the SRC under task no. 1607, and grants from NVIDIA Research and NEC labs. ...
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Project Description: Grade IV astrocytomas known as glioblastoma multiforme (GBM) are the most aggressive primary brain tumors, with a median survival rate of 15 months after diagnosis. Current methodologies for diagnosis include time-consuming histopathological reviews of biopsied brain tumor tissue to determine malignancy, which can delay early diagnosis and treatment. We propose to use microfluidics in combination with labeled magnetic beads to separate invasive glioma cells from other healthy neural tissue within a few hours. A strategy that combines rapid cell sorting with subsequent cell culture of a pure population of the patients glioma cells could not only speed up time to diagnosis, but also enhance personalized treatment. We hypothesize that incubating magnetic beads labeled with anti-epithelial cell adhesion molecule (epCAM) antibody will allow for the selective separation of glioma cells from other neural tissue cell types from co-culture, as judged by recent evidence that glioma ...
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We acknowledge support from the Center for Scientific Computing from the CNSI, MRL: an NSF MRSEC (DMR-1720256) and NSF CNS-0960316. ...
We acknowledge support from the Center for Scientific Computing from the CNSI, MRL: an NSF MRSEC (DMR-1720256) and NSF CNS-0960316. ...

Brevican - WikipediaBrevican - Wikipedia

Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein ... "Entrez Gene: BCAN brevican". Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic ... Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat ... Brevican is localised to the surface of neurons in the brain. In melanocytic cells, BCAN gene expression may be regulated by ...
more infohttps://en.wikipedia.org/wiki/Brevican

Brevican
     Summary Report | CureHunterBrevican Summary Report | CureHunter

Brevican: A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly ... Brevican. Subscribe to New Research on Brevican A BRAIN-specific hyalectin that may play a role in terminally differentiating ... 01/01/2012 - "The aim of this study was to examine whether brevican is a predictor of glioma and its roles in glioma cell ... 01/01/2012 - "Moreover, the role of brevican in the growth and progression of glioma was demonstrated by in vivo studies. ". 01 ...
more infohttp://www.curehunter.com/public/keywordSummaryD058581.do

Brevican ELISA & Assay KitsBrevican ELISA & Assay Kits

Compare and order Brevican ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended ... brevican core protein , brevican , brevican core protein-like , brevican soluble core protein , Brevican core protein , brain- ... Search Brevican ELISA Kits for other reactivities: Guinea Pig,. Pig (Porcine),. Dog (Canine),. Goat,. Cow (Bovine),. Chicken,. ... Images for product: Brevican (BCAN) ELISA Kit Diagramm of the ELISA kit to detect Human BCANwith the optical density on the x- ...
more infohttps://www.antikoerper-online.de/glycosaminoglycan-metabolic-process-pathway-65/bcan-elisa-kit-6620/

Porcine BCAN / Brevican Quant ELISA Kit | Custom | LSBioPorcine BCAN / Brevican Quant ELISA Kit | Custom | LSBio

Brevican It is a Custom assay which can detect BCAN / Brevican down to 0.313 ng/ml. ... Brevican ELISA Kit LS-F41799 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative detection of Porcine BCAN / ... It is based upon a Custom assay principle and can be used to detect levels of BCAN / Brevican as low as 0.188 nanograms per ... LS-F41799 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Porcine BCAN / Brevican. ...
more infohttps://www.lsbio.com/elisakits/porcine-bcan-brevican-elisa-kit-custom-elisa-ls-f41799/41799

Gene expression in tooth: brevicanGene expression in tooth: brevican

Expression of brevican in mouse tooth. Bcan. Species: mouse Location in mouse genome: chromosome 3, 90072619 - 90091338 (UCSC, ...
more infohttp://bite-it.helsinki.fi/BREVICAN.HTM

Neurofascin assembles a specialized extracellular matrix at the axon initial segment | JCBNeurofascin assembles a specialized extracellular matrix at the axon initial segment | JCB

In the brevican-EGFP fusion construct, EGFP was fused to the C terminus of the full-length cDNA of rat brevican. We introduced ... The brevican-based ECM interacts with NF-186. To determine if NF-186 and/or NrCAM interact with brevican, we expressed each CAM ... Brevican interacts with NF-186. (A-D) Soluble GFP-brevican (green) binds to COS-7 cells transfected with HA-tagged NF-186 (A [ ... The view that brevican is a ligand for NF-186 is consistent with the fact that brevican binds strongly to fibronectin type III ...
more infohttp://jcb.rupress.org/content/178/5/875

ANG1005 in Patients With Recurrent High-Grade GliomaANG1005 in Patients With Recurrent High-Grade Glioma

Brevican. A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly ...
more infohttps://www.bioportfolio.com/resources/trial/133142/ANG1005-in-Patients-With-Recurrent-High-Grade-Glioma.html

How neurons sense our everyday life | EurekAlert! Science NewsHow neurons sense our everyday life | EurekAlert! Science News

IMAGE: Brevican (in green) forms a meshwork in hippocampus. In this image, Brevican is expressed by two Parvalbumin cells (in ... In this new study, the researchers found that one of these proteins called Brevican, which is also one of the most abundant ... These novel findings show that Brevican is dynamically regulated by experiences coming from the environment and is ... found that this adaptability is shaped by a specific protein called Brevican. Moreover, loss of this protein leads to deficits ...
more infohttps://www.eurekalert.org/pub_releases/2017-07/kcl-hns071217.php

GO Gene ListGO Gene List

Brevican. NM_021948. NM_198427. Gene Info. BCAP31. B-cell receptor-associated protein 31. NM_001139457. NM_001256447. NM_005745 ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0065008

UniProt: Q61361UniProt: Q61361

DE RecName: Full=Brevican core protein; DE Flags: Precursor; GN Name=Bcan; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; ... FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 883 Brevican core protein. FT /FTId=PRO_0000017512. FT DOMAIN 35 154 Ig-like V-type. ... "Sequence and chromosomal localization of the mouse brevican gene."; RL Genomics 44:15-21(1997). RN [2] RP NUCLEOTIDE SEQUENCE [ ... CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; CC Note=Brevican; CC URL="http://www ...
more infohttps://www.genome.jp/dbget-bin/www_bget?uniprot:Q61361

Synaptic Biology Antibody Price ReductionSynaptic Biology Antibody Price Reduction

Brevican. N294A/6. Neuroligin-1. N97A/31. NrCAM. N343/26. SynCAM4. N244/5. ...
more infohttps://www.biolegend.com/synaptic_antibody_price_reduction

Expression of a Cleaved Brain-Specific Extracellular Matrix Protein Mediates Glioma Cell Invasion In Vivo | Journal of...Expression of a Cleaved Brain-Specific Extracellular Matrix Protein Mediates Glioma Cell Invasion In Vivo | Journal of...

In 9L-BEHAB/brevican tumors (lane 1), immunoreactivity for BEHAB/brevican is at 140 kDa. No evidence of a cleavage product is ... One set of transfectants, 9L-BEHAB/brevican, carried a construct encoding full-length BEHAB/brevican (amino acids 1-883), and a ... To study the protein product of the BEHAB/brevican mRNA, we examined BEHAB/brevican protein expression in experimental rodent ... BEHAB/brevican mRNA is detected. By contrast, BEHAB/brevican is undetectable in tumors that are not of glial origin, including ...
more infohttp://www.jneurosci.org/content/18/7/2370.long

Meta-analytical biomarker search of EST expression data reveals three differentially expressed candidates | BMC Genomics | Full...Meta-analytical biomarker search of EST expression data reveals three differentially expressed candidates | BMC Genomics | Full...

Researches have been conducted for the identification of differentially expressed genes (DEGs) by generating and mining of cDNA expressed sequence tags (ESTs) for more than a decade. Although the availability of public databases make possible the comprehensive mining of DEGs among the ESTs from multiple tissue types, existing studies usually employed statistics suitable only for two categories. Multi-class test has been developed to enable the finding of tissue specific genes, but subsequent search for cancer genes involves separate two-category test only on the ESTs of the tissue of interest. This constricts the amount of data used. On the other hand, simple pooling of cancer and normal genes from multiple tissue types runs the risk of Simpsons paradox. Here we presented a different approach which searched for multi-cancer DEG candidates by analyzing all pertinent ESTs in all categories and narrowing down the cancer biomarker candidates via integrative analysis with microarray data and selection of
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-S7-S12

Atlas StatusAtlas Status

BCAN (brevican). Need_an_author 2013-05. -. 54150. BCAP29. 7q22.3. 7. BCAP29 (B cell receptor associated protein 29). Need_an_ ...
more infohttp://atlasgeneticsoncology.org/Status/Status_Genes_B.html

Application # 2017/0315132. MULTIPLEXED TOTAL ANTIBODY AND ANTIBODY-CONJUGATED DRUG QUANTIFICATION
     ASSAY - Patents.comApplication # 2017/0315132. MULTIPLEXED TOTAL ANTIBODY AND ANTIBODY-CONJUGATED DRUG QUANTIFICATION ASSAY - Patents.com

21) Brevican (BCAN, BEHAB, Genbank accession no. AF229053). Gary S. C., et al Gene 256, 139-147, 2000; Clark H. F., et al ... Brevican; (22) EphB2R; (23) ASLG659; (24) PSCA; (25) GEDA; (26) BAFF-R (B cell-activating factor receptor, BLyS receptor 3, BR3 ...
more infohttp://patents.com/us-20170315132.html

Proteoglycan Quiz - The Full WikiProteoglycan Quiz - The Full Wiki

Brevican. Neurocan. [report] Question 6: They are also involved in binding cations (such as sodium, potassium and ________) and ...
more infohttp://quiz.thefullwiki.org/Proteoglycan

Bcan - PCR Primer Pair - SYBR | PrimePCR | Bio-RadBcan - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad

Brevican. Aliases:. Cspg7. RefSeq:. NC_000069.6 NT_039240.8. Ensembl:. ENSMUSG00000004892 Entrez:. 12032 ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/qmmuced0040206-primepcr-sybr-green-assay-bcan-mouse

BCAN (Human) ELISA Kit - (KA5888) - Products - AbnovaBCAN (Human) ELISA Kit - (KA5888) - Products - Abnova

OTTHUMP00000032164,OTTHUMP00000032165,brevican proteoglycan,chondroitin sulfate proteoglycan 7,chondroitin sulfate proteoglycan ...
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Student Publications | College of Graduate Studies |SUNY Upstate Medical UniversityStudent Publications | College of Graduate Studies |SUNY Upstate Medical University

Brevican knockdown reduces late-stage glioma tumor aggressiveness. . J Neurooncol. 120(1):63-72 (2014). ...
more infohttp://www.upstate.edu/grad/students/publications-archive.php

A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells | SpringerLinkA new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells | SpringerLink

BEHAB/brevican requires ADAMTS-mediated proteolytic leavage to promote glioma invasion. J Neurooncol. 2008;88:261-72. ...
more infohttps://link.springer.com/article/10.1007%2Fs13277-014-1949-2

Astrocyte scar formation aids central nervous system axon regeneration.  - PubMed - NCBIAstrocyte scar formation aids central nervous system axon regeneration. - PubMed - NCBI

Brevican (BCAN) production by scar-forming astrocytes and non-astrocyte cells. Images show individual fluorescence channels of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/27027288?dopt=Abstract
  • However, loss of NF-186 blocked assembly of the brevican-based AIS extracellular matrix, and NF-186 overexpression caused somatodendritic brevican clustering. (rupress.org)
  • Thus, NF-186 assembles and links the specialized brevican-containing AIS extracellular matrix to the intracellular cytoskeleton. (rupress.org)
  • Brevican is a member of the lectican protein family. (wikipedia.org)
  • In their new study, the multidisciplinary team of researchers led by the Centre for Developmental Neurobiology (CDN) and MRC Centre for Neurodevelopmental Disorders (MRC CNDD) at the Institute of Psychiatry, Psychology & Neuroscience, found that this adaptability is shaped by a specific protein called Brevican. (eurekalert.org)
  • In this new study, the researchers found that one of these proteins called Brevican, which is also one of the most abundant proteins found in the brain, influences neuronal plasticity, orchestrating a dedicated molecular program in response to changes from the environment. (eurekalert.org)
  • reported that in vitro a specialized brevican-containing matrix surrounds the AIS. (rupress.org)