DiseasesChemicals and DrugsPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth CareGeographicals
Bretylium CompoundsBretylium TosylateGuanethidineSympatholyticsTyramineAmidinesPharmacologyReserpinePempidinePentolinium TartrateHexamethonium CompoundsPatents as TopicNorepinephrinePainClonidineAdrenergic alpha-AgonistsAdrenergic alpha-2 Receptor AgonistsVaginismusVulvitisVulvar VestibulitisDyspareuniaEnzyme ActivatorsSexual Dysfunctions, PsychologicalCystitis, InterstitialAllosteric RegulationAllosteric SiteLigandsOntarioGene LibraryN-MethylscopolamineGallamine Triethiodide
Bretylium Compounds
Bretylium Tosylate
An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.
Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Sympatholytics
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Amidines
Pharmacology
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Pempidine
A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
Pentolinium Tartrate
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Hexamethonium Compounds
Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Clonidine
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Adrenergic alpha-Agonists
Drugs that selectively bind to and activate alpha adrenergic receptors.
Adrenergic alpha-2 Receptor Agonists
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
Vaginismus
Recurrent or persistent involuntary SPASM of the outer muscles of the VAGINA, occurring during vaginal penetration.
Vulvitis
Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.
Vulvar Vestibulitis
Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area.
Dyspareunia
Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.
Enzyme Activators
Compounds or factors that act on a specific enzyme to increase its activity.
Sexual Dysfunctions, Psychological
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)
Cystitis, Interstitial
A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.
Allosteric Regulation
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
Allosteric Site
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
Ligands
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Ontario
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Gene Library
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
N-Methylscopolamine
A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Gallamine Triethiodide
A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)

Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. (1/124)

We examined the effect of stress on colonic epithelial physiology, the role of corticotropin-releasing hormone (CRH), and the pathways involved. Rats were restrained or injected intraperitoneally with CRH or saline. Colonic segments were mounted in Ussing chambers, in which ion secretion and permeability (conductance and probe fluxes) were measured. To test the pathways involved in CRH-induced changes, rats were pretreated with hexamethonium, atropine, bretylium, doxantrazole, alpha-helical CRH-(9-41) (all intraperitoneally), or aminoglutethimide (subcutaneously). Restraint stress increased colonic ion secretion and permeability to ions, the bacterial peptide FMLP, and horseradish peroxidase (HRP). These changes were prevented by alpha-helical CRH-(9-41) and mimicked by CRH (50 microgram/kg). CRH-induced changes in ion secretion were abolished by alpha-helical CRH-(9-41), hexamethonium, atropine, or doxantrazole. CRH-stimulated conductance was significantly inhibited by alpha-helical CRH-(9-41), hexamethonium, bretylium, or doxantrazole. CRH-induced enhancement of HRP flux was significantly reduced by all drugs but aminoglutethimide. Peripheral CRH reproduced stress-induced colonic epithelial pathophysiology via cholinergic and adrenergic nerves and mast cells. Modulation of stress responses may be relevant to the management of colonic disorders.  (+info)

Preventing ventricular fibrillation by flattening cardiac restitution. (2/124)

Ventricular fibrillation is the leading cause of sudden cardiac death. In fibrillation, fragmented electrical waves meander erratically through the heart muscle, creating disordered and ineffective contraction. Theoretical and computer studies, as well as recent experimental evidence, have suggested that fibrillation is created and sustained by the property of restitution of the cardiac action potential duration (that is, its dependence on the previous diastolic interval). The restitution hypothesis states that steeply sloped restitution curves create unstable wave propagation that results in wave break, the event that is necessary for fibrillation. Here we present experimental evidence supporting this idea. In particular, we identify the action of the drug bretylium as a prototype for the future development of effective restitution-based antifibrillatory agents. We show that bretylium acts in accord with the restitution hypothesis: by flattening restitution curves, it prevents wave break and thus prevents fibrillation. It even converts existing fibrillation, either to a periodic state (ventricular tachycardia, which is much more easily controlled) or to quiescent healthy tissue.  (+info)

Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip. (3/124)

We tested the hypothesis that a reduction in sympathetic tone to exercising forearm muscle would increase blood flow, reduce muscle acidosis, and attenuate reflex responses. Subjects performed a progressive, four-stage rhythmic handgrip protocol before and after forearm bier block with bretylium as forearm blood flow (Doppler) and metabolic (venous effluent metabolite concentration and (31)P-NMR indexes) and autonomic reflex responses (heart rate, blood pressure, and sympathetic nerve traffic) were measured. Bretylium inhibits the release of norepinephrine at the neurovascular junction. Bier block increased blood flow as well as oxygen consumption in the exercising forearm (P < 0.03 and P < 0.02, respectively). However, despite this increase in flow, venous K(+) release and H(+) release were both increased during exercise (P < 0.002 for both indexes). Additionally, minimal muscle pH measured during the first minute of recovery with NMR was lower after bier block (6.41 +/- 0.08 vs. 6.20 +/- 0.06; P < 0.036, simple effects). Meanwhile, reflex effects were unaffected by the bretylium bier block. The results support the conclusion that sympathetic stimulation to muscle during exercise not only limits muscle blood flow but also appears to limit anaerobiosis and H(+) release, presumably through a preferential recruitment of oxidative fibers.  (+info)

Ciliary ganglion stimulation. II. Neurogenic, intraocular pathway for excitatory effects on aqueous humor production and outflow. (4/124)

Data obtained suggest that preganglionic stimulation of the ciliary ganglion produces an increase of aqueous humor formation and of facility of outflow "C" through the following neurogenic pathway: (1) the preganglionic fibers synapse in the ciliary ganglion as evidenced by depression of the response with nicotine applied topically to the ganglion. (2) The impulse proceeds to the equivalent of an intraocular interneuron which can be blocked by low concentrations of atropine and has been previously identified as being an E-2 receptor site. (3) From the interneuron, activity is ultimately exerted without further synapse on alpha-adrenergic receptors through the release of norepinephrine from the neuronal terminals. The adrenergic mechanism of action is supported by the inhibition of the responses by phenoxybenzamine, bretylium, and guanethidine. Constriction of efferent ciliary process blood vessels by neuron-released norepinephrine seems to be the end effect responsible for the increased production of aqueous humor. The site of the end response to increase "C" is unclear.  (+info)

Effect of destruction of the posterior pituitary on the diuresis from left atrial receptors. (5/124)

1. In anaesthetized dogs, stimulation of atrial receptors after destruction of the pituitary gland results in a diuresis. This response was not abolished by the administration of bretylium tosylate and was also observed in a surgically denervated kidney. 2. The diuresis is qualitatively similar to that observed in anaesthetized dogs with intact pituitary glands. 3. It is concluded that the diuresis which results from stimulation of the left atrial receptors is mediated by a blood-borne agent which is not the antidiuretic hormone.  (+info)

Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats. (6/124)

Acute cold exposure-induced activation of gastric myenteric neurons in conscious rats was examined on longitudinal muscle-myenteric plexus whole mount preparations. Few Fos-immunoreactive (IR) cells (<1/ganglion) were observed in 24-h fasted rats semirestrained at room temperature. Cold exposure (4 degrees C) for 1-3 h induced a time-related increase of Fos-IR cells in corpus and antral myenteric ganglia with a maximal plateau response (17 +/- 3 and 18 +/- 3 cells/ganglion, respectively) occurring at 2 h. Gastric vagotomy partly prevented, whereas bilateral cervical vagotomy completely abolished, Fos expression in the myenteric cells induced by cold exposure (2 h). Hexamethonium (20 mg/kg) also prevented 3-h cold exposure-induced myenteric Fos expression by 76-80%, whereas atropine or bretylium had no effect. Double labeling revealed that cold (3 h)-induced Fos-IR myenteric cells were mainly neurons, including a substantial number of choline acetyltransferase-containing neurons and most NADPH-diaphorase-positive neurons. These results indicate that acute cold exposure activates cholinergic as well as nitrergic neurons in the gastric myenteric ganglia through vagal nicotinic pathways in conscious rats.  (+info)

Influence of cocaine and sodium on bretylium uptake by reserpine-treated guinea-pig left atrium. (7/124)

1 The effects of cocaine and sodium on bretylium uptake into sympathetic nerve terminals were investigated in the reserpine-treated guinea-pig left atrium. The ability of bretylium pretreatment to increase the retention of noradrenaline was used as an index of bretylium uptake. Such increased retention has been assessed both by direct measurement and by the ability of tyramine to produce an inotropic response. 2 The restoration of the response to tyramine after incubation with noradrenaline was abolished when the atrium was pretreated with bretylium in the presence of cocaine. When bretylium was added before cocaine, or when alpha-methyl-noradrenaline (not a substrate for monoamine oxidase) was used for incubation, the responses to tyramine were restored in the normal way. 3 Bretylium greatly enhanced the retention of [3-H]-noradrenaline; when bretylium was added in the presence of cocaine, [3-H]-noradrenaline retention was severely impaired. 4 Pretreatment with bretylium in a low-sodium (25 mM) or sodium-free medium significantly decreased the retention of [3-H]-noradrenaline, as compared with the control. 5 Potassium deprivation did not modify the enhanced retention of [3-H]-noradrenaline induced by bretylium pretreatment. 6 Bretylium was released from the nerve terminals by exposure of the preparation to a sodium-free medium or to a solution containing calcium 50 mM, leading to a considerable decrease in [3-H]-noradrenaline retention. 7 The results are consistent with the view that both cocaine and sodium deprivation block the uptake of bretylium by the adrenergic nerve terminals, and that bretylium is probably taken up by a mechanism similar to or identical with the uptake system for noradrenaline and other amines.  (+info)

Studies of uptake of the bretylium analogue, iodobenzyltrimethylammonium iodide, by non-primate, monkey and human hearts. (8/124)

Uptake of (+/-)-[3H]-noradrenaline, [14C]-bretylium and [125I]-o-iodobenzyltrimethylammonium iodide (RIBA) by rat heart was studied by the Langendorff technique. All three compounds showed significant uptake. 2 Corticosterone and 17-beta-oestradiol inhibited the uptake of all three compounds by rat heart, a finding consistent with extraneuronal uptake (uptake2). 3 [131I]-RIBA was injected intravenously into pigs and monkeys (M. speciosus). Myocardial samples taken from pigs killed 1 and 2 h after injection showed significant uptake. No significant uptake was found in myocardial samples of monkeys killed 10 min, 2 h and 24 h, respectively, after injection. 4 Four normal human volunteers received [125I]-RIBA intravenously and the image of the precordial area was followed by means of scintillation camera for the first 4 h after injection. In two of the subjects, the scintigrams were repeated at 22 and 23 h after injection, respectively. No evidence of myocardial uptake was observed. 5 These results suggest the possibility that man and at least one other primate species may differ from lower species with regard to uptake.  (+info)

Effect of Guanethidine and Bretylium on the Dog Heart-Lung Preparation | Circulation ResearchEffect of Guanethidine and Bretylium on the Dog Heart-Lung Preparation | Circulation Research
Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...
http://circres.ahajournals.org/content/9/1/83
Bretylium - WikipediaBretylium - Wikipedia
Bretylium (also bretylium tosylate) is an antiarrhythmic agent. It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is considered a class III antiarrhythmic. The dose is 5-10 mg/kg and side effects are high blood pressure followed by low blood pressure and ventricular ectopy. Originally introduced in 1959 for the treatment of hypertension. Its use as an antiarrhythmic for ventricular fibrillation was discovered and patented by Marvin Bacaner in 1969 at the University of Minnesota. The American Heart Association removed bretylium from their 2000 ECC/ACC guidelines due to its unproven efficacy and ongoing supply problems. Many have cited these supply problems as an issue of raw materials needed in the production of Bretylium. By the release of the AHA 2005 ECC/ACC guidelines there is no mention of Bretylium and it is virtually unavailable throughout most of the world. As ...
https://en.wikipedia.org/wiki/Bretylium
Bretylium (Bretylol) | Daviss Drug GuideBretylium (Bretylol) | Daviss Drug Guide
Find information on Bretylium (Bretylol) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51109/all/bretylium?refer=true
New DrugsBretylium Tosylate: A Newly Available Antiarrhythmic Drug for Ventricular Arrhythmias | Annals of Internal Medicine |...New DrugsBretylium Tosylate: A Newly Available Antiarrhythmic Drug for Ventricular Arrhythmias | Annals of Internal Medicine |...
Bretylium tosylate (Bretylol) has recently been approved for parenteral use against resistant ventricular arrhythmias. The pharmacologic action of bretylium is complex, and its antiarrhythmic action differs significantly from other drugs. Bretylium is an adrenergic neuronal blocking agent taken up selectively at peripheral adrenergic nerve terminals, where it initially releases norepinephrine (sympathomimetic effect) and then produces adrenergic neuronal blockade. It has direct cardiac membrane effect to prolong action potential duration and effective refractory period but, unlike other membrane active antiarrhythmic agents, does not depress conduction velocity or automaticity. Bretylium increases ventricular fibrillation threshold and prevents the decrease in ventricular fibrillation threshold associated with myocardial ischemia. It does not depress myocardial contractility. Clinical studies have shown parenteral bretylium to be effective in suppressing ventricular arrhythmias, particularly ...
http://annals.org/aim/article-abstract/693254/new-drugs-bretylium-tosylate-newly-available-antiarrhythmic-drug-ventricular-arrhythmias
Bretylium tosylateBretylium tosylate
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician ...
http://www.chemicaldictionary.org/dic/B/Bretylium-tosylate_1338.html
Sorafenib Tosylate With or Without Gemcitabine Hydrochloride and Oxaliplatin in Treating Patients With Locally Advanced,...Sorafenib Tosylate With or Without Gemcitabine Hydrochloride and Oxaliplatin in Treating Patients With Locally Advanced,...
RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether sorafenib tosylate is more effective when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with liver cancer.. PURPOSE: This randomized phase II trial is studying sorafenib tosylate to see how well it works when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with locally advanced, unresectable, or metastatic liver cancer. ...
https://clinicaltrials.gov/ct2/show/NCT00941967
Sorafenib Tosylate - Sorafenib Tosylate Manufacturer,Exporter,Service Provider And TraderSorafenib Tosylate - Sorafenib Tosylate Manufacturer,Exporter,Service Provider And Trader
WAGHESHWARI IMPEX PRIVATE LIMITED - Manufacturer, Exporter, Service Provider And Trader Of Sorafenib Tosylate,Mumbai,Maharashtra,India. Find More Detail For Sorafenib Tosylate Manufacturers,Exporter,Service Provider And Trader From Mumbai,Maharashtra,India
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COA of Sorafenib Tosylate | Certificate of Analysis | AbMole BioScienceCOA of Sorafenib Tosylate | Certificate of Analysis | AbMole BioScience
COA of Sorafenib Tosylate contains the actual results obtained from testing performed as part of quality control. View our Sorafenib Tosylate specific physical and chemical properties, and analytical data.
http://www.abmole.com/literature/sorafenib-tosylate-coa.html
Hemicholinium 3 Summary Report | CureHunterHemicholinium 3 Summary Report | CureHunter
Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
http://www.curehunter.com/public/keywordSummaryD006426-Hemicholinium-3.do
Age‐related circulatory responses to whole body cooling: observations by heart rate variability - Lunds universitetAge‐related circulatory responses to whole body cooling: observations by heart rate variability - Lunds universitet
During the cooling, BP increased in both subjects (young from 95/69 to 132/75 mmHg, old from 125/68 to 176/101 mmHg), the latter exhibiting a prominent rise in diastolic values after cooling. HRV parameters increased in both subjects during the cold exposure being modest in the younger subject as compared to the older one. Also, recovery from the cold in terms of HRV was faster in the younger subject. The present preliminary observations indicate that older age is coupled with altered HRV response to a mild whole‐body skin cooling ...
https://portal.research.lu.se/portal/sv/publications/agerelated-circulatory-responses-to-whole-body-cooling-observations-by-heart-rate-variability
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IS THIS SCABIES?IS THIS SCABIES?
5ys, male, whole body skin rash with low grade fever (99°F -100°F). Severe itching. Stool urine normal. Please suggest me to diagnosis and treatment.
https://curofy.com/discussion/5ys-male-whole-body-skin-rash-with-low-grade-fever-99-f-100-f-severe-itching-stool-urine-normal-97feed9de9c50a142d41c3ce25403939
Sciencemadness Discussion Board - Preparation of methyl tosylate, safe methylating agent - Powered by XMB 1.9.11Sciencemadness Discussion Board - Preparation of methyl tosylate, safe methylating agent - Powered by XMB 1.9.11
To 15.2 g vanillin (0.1 mol) a calculated amount of kalihydrat (probably KOH) was added and dissolved in 75 ml MeOH. 18 g methyl tosylate (0.1 mol) and heated on a water bath for 1.5 h to reflux. As soon as the the light yellow, clear solution starts boiling the potassium salt of methyl toluenesulfonic acid starts to precipitate. After 1.5 h everything is poured in about 300 ml of H2O. First there is a white emulsion which starts to separate a light yellow oil. The aqeuous solution and the oil is extracted exhaustive with Et2O, the organic phase is washed twice with 10 ml 5% aqeuous KOH to remove unreacted vanillin. The organic phase turns almost colourless, the alkaline solution is light yellow. The organic phase is washed with H2O, dried with freshly sulphate (probably MgSO4 or Na2SO4) and evaporated. The oily residue solidifies on cooling (melting point: 42-43°C ...
http://www.sciencemadness.org/talk/viewthread.php?tid=11004&page=2
Sorafenib Tosylate Following a Liver Transplant in Treating Patients With Liver Cancer - Full Text View - ClinicalTrials.govSorafenib Tosylate Following a Liver Transplant in Treating Patients With Liver Cancer - Full Text View - ClinicalTrials.gov
PRIMARY OBJECTIVES:. I. Two-year recurrence free survival (RFS).. SECONDARY OBJECTIVES:. I. One-year recurrence free survival. II. Overall survival (OS). III. Safety. IV. Impact of drug-drug interactions (i.e. immunosuppression agents). V. Impact of biomarkers (alpha-fetoprotein [AFP], protein-induced by vitamin K absence or antagonist II [PIVKA II]).. VI. Effects of therapy on wound healing. VII. Impact of hepatitis C viral recurrence.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive sorafenib tosylate orally (PO) twice daily (BID).. ARM II: Patients receive placebo PO BID.. In both arms treatment continues for 24 months in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 6 months for 2 years. ...
https://clinicaltrials.gov/ct2/show/NCT01624285?cond=%22Liver+Neoplasms%22&rank=15
LY 2584702 tosylate | S6K1 inhibitor | LY 2779964 | LY2584702 | CAS [1082949-68-5] - [1082949-67-4] | Axon 2464 | Axon Ligand™...LY 2584702 tosylate | S6K1 inhibitor | LY 2779964 | LY2584702 | CAS [1082949-68-5] - [1082949-67-4] | Axon 2464 | Axon Ligand™...
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Human Body SKIN: Question Preview (30536)Human Body SKIN: Question Preview (30536)
Human Body SKIN: Basic Questions About The First 2 Layers Of The Skin Explanations Of The Epidermis And Dermis Other Facts About The Skin (30536)
https://reviewgamezone.com/preview.php?id=30536
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Guanethidine Sulfate - Drugs.comGuanethidine Sulfate - Drugs.com
Guanethidine Sulfate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Guanethidine Sulfate is available on the Drugs.com website.
https://www.drugs.com/international/guanethidine-sulfate.html
Guanethidine (Ismelin) | Daviss Drug GuideGuanethidine (Ismelin) | Daviss Drug Guide
Find information on Guanethidine (Ismelin) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/51371/all/guanethidine?q=orthostatic
Plus itPlus it
Drugs. The following drugs were used: bretylium tosylate (Burroughs Wellcome, Research Triangle Park, NC); (-)-cocaine hydrochloride (Merck, Darmstadt, Germany), desipramine hydrochloride (Ciba-Geigy AG, Basel, Switzerland); 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone (U-0521; The Upjohn Company, Kalamazoo, MI); (-)-norepinephrine hydrochloride (Sigma-Aldrich, St. Louis, MO); (-)-[7-3H] (N)norepinephrine hydrochloride (specific activity, 12.0-14.9 Ci/mmol; PerkinElmer Life Sciences, Boston, MA); pargyline hydrochloride (Abbott Laboratories, North Chicago, IL); and reboxetine hydrochloride, a racemic mixture of (-)-R,R-and (+)-S,S-(2-[α[2-ethoxyphenoxy]benzyl]-morpholine hydrochloride (synthesized in the Department of Medicinal Chemistry, H. Lundbeck A/S, Copenhagen, Denmark).. Stock solutions were prepared in twice-distilled water (bretylium, cocaine, desipramine, norepinephrine, [3H]norepinephrine, and pargyline). The stock solutions were diluted with physiological salt solution (PSS) to the ...
http://jpet.aspetjournals.org/content/306/3/995
Edoxaban tosylate (DU-176b) | FXa Inhibitor | MedChemExpressEdoxaban tosylate (DU-176b) | FXa Inhibitor | MedChemExpress
Edoxaban tosylate (DU-176b) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban tosylate is an anticoagulant agent and can be used for stroke prevention. Edoxaban tosylate is a also weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban tosylate has antithrombotic properties and has potential for thromboembolic diseases treatment. - Mechanism of Action & Protocol.
https://www.medchemexpress.com/edoxaban-tosylate.html
Morphometric characterization of individual sympathetic postganglionic by Gary C. WalterMorphometric characterization of individual sympathetic postganglionic by Gary C. Walter
A full description of the terminal morphology of sympathetic postganglionic axons innervating the musculature of the gastrointestinal (GI) tract has not been available. Furthermore, common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of the techniques employed to distinguish the fibers and complicated by inconsistent findings generated with various methodologies. Thus, the present experiment used modern neural tracer techniques to provide high-resolution labeling of sympathetic fibers projecting to the smooth muscle wall of the GI tract. Fischer 344 rats (N = 50) received injections of dextran biotin into the left celiac and superior mesenteric ganglia. Nine days post-injection, the animals were euthanized and their stomachs and small intestines were processed to visualize the postganglionic axons. Myenteric neurons were counterstained with Cuprolinic Blue. Individual sympathetic arbors (n = 154) in the gut wall were
http://docs.lib.purdue.edu/open_access_dissertations/381/
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Bethanidine | Colorado PROFILESBethanidine | Colorado PROFILES
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BP Chapter 15 FlashcardsBP Chapter 15 Flashcards
A neurotransmitter produced and released by sympathetic postganglionic neurons to accelerate organ activity. Also produced in the brainstem and found in projections throughout the brain. Here, a hormone secreted by the adrenal medulla under the control of the sympathetic nervous system, which prepares the body for action. ...
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Horseradish peroxidase localization of the sympathetic postganglionic neurons innervating the cat heart<...Horseradish peroxidase localization of the sympathetic postganglionic neurons innervating the cat heart<...
TY - JOUR. T1 - Horseradish peroxidase localization of the sympathetic postganglionic neurons innervating the cat heart. AU - Shih, Chun Jen. AU - Chuang, King Shun. AU - Tsai, Shin Han. AU - Liu, Jiang Chuan. PY - 1985. Y1 - 1985. N2 - The localization of the sympathetic postganglionic neurons innervating the cat heart has been investigated by using retrograde axonal transport of horseradish peroxidase (HRP). HRP was injected into the subepicardial layers of 4 different cardiac regions. The animals were sacrificed 72-96 h later and fixed by perfusion via the left ventricle. The paravertebral sympathetic ganglia from the superior cervical, middle cervical and stellate ganglia to T10 ganglia were removed and processed for HRP identification. Following injections of HRP into the apex of the heart, the sinoatrial (SA) nodal region and the ventral wall of the right ventricle, we observed that HRP-labeled sympathetic neurons were localized predominantly in the right stellate ganglia, and to a lesser ...
https://tmu.pure.elsevier.com/en/publications/horseradish-peroxidase-localization-of-the-sympathetic-postgangli
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Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does...Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does...
RATIONALE: Sorafenib tosylate and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib tosyla
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The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine.. The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues.. ...
http://jpet.aspetjournals.org/content/142/1/76
Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male ...Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male ...
misc{3a0513da-a6c0-4388-821c-b9474f344b0d, author = {Kuklane, Kalev and Vanggaard, Leif and Smolander, Juhani and Halder, Amitava and Lundgren Kownacki, Karin and Gao, Chuansi and Viik, Jari and Alametsä, Jarmo}, language = {eng}, note = {Conference Abstract}, pages = {48--48}, publisher = {International Society for Environmental Ergonomics}, series = {Environmental Ergonomics}, title = {Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male - a pre-study}, volume = {XVI}, year = {2015 ...
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Biomarkers in Blood Samples From Patients With Refractory Non-Small Cell Lung Cancer Previously Treated With Sorafenib TosylateBiomarkers in Blood Samples From Patients With Refractory Non-Small Cell Lung Cancer Previously Treated With Sorafenib Tosylate
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identif
http://www.knowcancer.com/cancer-trials/NCT01124669/
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Your search returned too many results to display in the tree. Showing only the first 100 items. For a full search click here. ...
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Antiarrhythmic agentAntiarrhythmic agent
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, ... Sympatholytic drugs (drugs blocking the effects of the sympathetic nervous system): examples included bretylium and adrenergic ... bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant and dronedarone. Class IV agents are slow non- ...
https://en.wikipedia.org/wiki/Antiarrhythmic_agent
Aconitum napellusAconitum napellus
Like other species in the genus, A. napellus contains several poisonous compounds, including enough cardiac poison that it was ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ...
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PempidinePempidine
The "trivial" name of this compound is triacetonamine. *^ The boiling point of 147° given by these authors for their N,2,2,6,6- ... Two early syntheses of this compound are those of Leonard and Hauck,[6] and Hall.[5] These are very similar in principle: ... with additional data related to several structurally simpler compounds.[3] ...
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List of adrenergic drugsList of adrenergic drugs
These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the ... Bethanidine Bretylium Guanadrel Guanazodine Guanclofine Guanethidine Guanoxan Oxidopamine (6-hydroxydopamine) Prischich, Davia ...
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Trimetaphan camsilateTrimetaphan camsilate
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Serotonin releasing agentSerotonin releasing agent
References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 ...
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GuanidineGuanidine
"Guanidine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. ... Guanidines are a group of organic compounds sharing a common functional group with the general structure (R. 1R. 2N)(R. 3R. 4N) ... Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong ... The compound was first synthesized in 1861 by the oxidative degradation of an aromatic natural product, guanine, isolated from ...
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DihydropyridineDihydropyridine
"1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. ...
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PhenibutPhenibut
Compound. α2δ. GABAB Phenibut. ND. 177 (R)-Phenibut. 23. 92 ... Bromide compounds (e.g., potassium bromide). *Carbamates (e.g ...
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PhenytoinPhenytoin
Bromide compounds (e.g., potassium bromide). *Carbamates (e.g., meprobamate). *Carbamazepine. *Chloralose ...
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Magnesium sulfateMagnesium sulfate
Chemical articles with multiple compound IDs. *Multiple chemicals in an infobox that need indexing ...
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ValpromideValpromide
"dipropylacetamide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. ... M 25 [1186293-14-0] is also one of the compounds that has a reputation. ...
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GliclazideGliclazide
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NefopamNefopam
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3,4-Methylenedioxy-N-ethylamphetamine3,4-Methylenedioxy-N-ethylamphetamine
Alexander Shulgin conducted research on methylenedioxy compounds in the 1960s. In a 1967 lab notebook entry, Shulgin briefly ...
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DimethoxyamphetamineDimethoxyamphetamine
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FamprofazoneFamprofazone
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Beta blockerBeta blocker
Cleophas, Ton (1995). Beta-blockers in hypertension and angina pectoris: different compounds, different strategies. Kluwer ... usually an endogenous compound, such as norepinephrine). See partial agonist for a more general description. ...
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DomperidoneDomperidone
Sneader, Walter (2005). "Plant Product Analogues and Compounds Derived from Them". Drug discovery : a history. Chichester: John ...
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CarbamazepineCarbamazepine
Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide). *Carbamazepine. *Chloralose ...
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TrifluoromethylphenylpiperazineTrifluoromethylphenylpiperazine
Unlike the related piperazine compound meta-chlorophenylpiperazine (mCPP), TFMPP has insignificant affinity for the 5-HT3 ... "Interaction of amphetamines and related compounds at the vesicular monoamine transporter". Journal of Pharmacology and ...
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MethylhexanamineMethylhexanamine
"1,3-Dimethylpentylamine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26 March ... 12 The compound is an aliphatic amine; the pharmaceutical industry had a strong interest in compounds in this class as nasal ... Historically, the compound has been used as a nasal decongestant but its oral application is largely unstudied leaving the ... under many names as a stimulant or energy-boosting dietary supplement under the claim that it is similar to certain compounds ...
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DiFMDADiFMDA
These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non- ... Since a major route of the normal metabolism of these compounds is scission of the methylenedioxy ring, producing neurotoxic ... fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and ...
https://en.wikipedia.org/wiki/DiFMDA
MDAIMDAI
Because these compounds selectively release serotonin in the brain but have little effect on dopamine or noradrenaline levels, ...
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AmfepramoneAmfepramone
Diethylamino compounds. Hidden categories: *All articles with dead external links. *Articles with dead external links from July ...
https://en.wikipedia.org/wiki/Amfepramone
മെത്തലീൻ ഡയോക്സി മെത് ആംഫ്റ്റമൈൻ - വിക്കിപീഡിയമെത്തലീൻ ഡയോക്സി മെത് ആംഫ്റ്റമൈൻ - വിക്കിപീഡിയ
References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 ...
https://ml.wikipedia.org/wiki/മെത്തലീൻ_ഡയോക്സി_മെത്_ആംഫ്റ്റമൈൻ
Patent USRE41998 - Compositions and methods of treatment of sympathetically maintained pain - Google PatentsPatent USRE41998 - Compositions and methods of treatment of sympathetically maintained pain - Google Patents
wherein the compound is selected from the group consisting of bretylium and methylapogalanthamine. ... wherein the c compound is a compound of Formula VII wherein R8 is hydrogen, R 9 and R 10 are alkoxy; R 11 is selected from the ... wherein the compound is a compound of Formula VI wherein R8 is hydrogen, R 9 and R 10 are alkoxy; R 11 is selected from the ... wherein the compound is a compound of Formula VI, wherein R9 and R 10 are methoxy; R 11 is selected from the group consisting ...
http://www.google.com/patents/USRE41998?dq=6,034,652
Quaternary Ammonium Compounds - DrugBankQuaternary Ammonium Compounds - DrugBank
Bretylium. Sodium/potassium-transporting ATPase subunit alpha-1. target. DB01199. Tubocurarine. Neuronal acetylcholine receptor ... Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with ... Bretylium. For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ... Typically employed as the cetylpyridinium chloride salt, this compound is commonly used as an active ingredient in various over ...
https://www.drugbank.ca/categories/DBCAT000265
Patente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google PatentesPatente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google Patentes
... estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG- ... using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, α- ... Compounds that deplete norepinephrine stores include, but are not limited to, reserpine, guanethidine and bretylium. Compounds ... In some embodiments, the at least two compounds are selected from the same class of compounds (e.g., both compounds are ...
http://www.google.es/patents/US6987129
Bretylium Differentiates between Distinct Signal Transducing Pathways in Human Lymphocytes<...Bretylium Differentiates between Distinct Signal Transducing Pathways in Human Lymphocytes<...
Interleukin-2 Receptors Chemical Compounds * Chemical activation Chemical Compounds * Signal Transduction Medicine & Life ... Bretylium Differentiates between Distinct Signal Transducing Pathways in Human Lymphocytes. C. Pieri, Z. Bacso, R. Recchioni, F ... Bretylium Differentiates between Distinct Signal Transducing Pathways in Human Lymphocytes. / Pieri, C.; Bacso, Z.; Recchioni, ... Pieri, C., Bacso, Z., Recchioni, R., Moroni, F., Balazs, M., Gaspar, R., & Damjanovich, S. (1993). Bretylium Differentiates ...
https://moh-it.pure.elsevier.com/en/publications/bretylium-differentiates-between-distinct-signal-transducing-path
US6214823B1 - Benzodiazepine derivatives as antiarrhythmic agents - Google PatentsUS6214823B1 - Benzodiazepine derivatives as antiarrhythmic agents - Google Patents
This invention is concerned with novel compounds represented by structural formula I which are useful in the treatment of ... AAQOQKQBGPPFNS-UHFFFAOYSA-N Bretylium Chemical compound data:image/svg+xml;base64, ... 150000001875 compounds Chemical class 0 abstract claims description 47 * 239000003416 antiarrhythmic agent Substances 0 ... compounds. phenyl. Prior art date. 1997-10-17. Legal status (The legal status is an assumption and is not a legal conclusion. ...
https://patents.google.com/patent/US6214823B1/en
Search | Global Index MedicusSearch | Global Index Medicus
Animals , Benzyl Compounds/pharmacology , Bretylium Compounds/pharmacology , Choline/pharmacology , Cold Temperature , ... Bretylium Compounds/pharmacology , Choline/antagonists & inhibitors , Hemicholinium 3/pharmacology , Hexamethonium Compounds/ ... Animals , Bretylium Compounds/pharmacology , Digoxin/pharmacology , Guanethidine/pharmacology , Heart Atria/drug effects , ... Animals , Bretylium Compounds/pharmacology , Choline/pharmacology , Guanethidine/pharmacology , Guinea Pigs , Ileum/drug ...
https://search.bvsalud.org/gim/?lang=en&q=mh:Bretylium+Compounds/pharmacology
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
Bretylium Compounds - therapeutic use , Phentolamine - therapeutic use , Bretylium Compounds - adverse effects , Humans , ... bis-trimethylammonium compounds - administration & dosage (3) 3 Filter by. Remove filter. bis-trimethylammonium compounds - ... METHONIUM COMPOUNDS IN THE TREATMENT OF HYPERTENSION by WOLFFE, JOSEPH B and WALKOW, M.B and NAGLER, J. HERBERT and ANASTASI, ... Bis-Trimethylammonium Compounds - therapeutic use , Chlorthalidone - therapeutic use , Hexamethonium Compounds - therapeutic ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Bis-Trimethylammonium%20Compounds%20-%20therapeutic%20use
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
Blood Pressure , Ventricular Fibrillation - prevention & control , Bretylium Compounds - therapeutic use , Resuscitation - ... Full Text Antifibrillatory effects of high dose bretylium and a lidocaine-bretylium combination during cardiopulmonary ...
https://query.library.utoronto.ca/index.php/search/q?kw=Author:Hanyok,%20James%20J
February 2018 - When do the patents on BRETYLIUM TOSYLATE IN DEXTROSE 5% expire, and when will generic BRETYLIUM TOSYLATE IN...February 2018 - When do the patents on BRETYLIUM TOSYLATE IN DEXTROSE 5% expire, and when will generic BRETYLIUM TOSYLATE IN...
There are three drug master file entries for this compound. Additional details are available on the bretylium tosylate profile ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-002. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-003. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-001. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ...
https://www.drugpatentwatch.com/p/tradename/BRETYLIUM+TOSYLATE+IN+DEXTROSE+5%25
Nitrogen Compounds - DrugBankNitrogen Compounds - DrugBank
Bretylium. Sodium/potassium-transporting ATPase subunit alpha-1. target. Tubocurarine. Neuronal acetylcholine receptor subunit ... Nitrogen Compounds. Accession Number. DBCAT000269. Description. Inorganic compounds that contain nitrogen as an integral part ... A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the ... Bretylium. A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the ...
https://go.drugbank.com/categories/DBCAT000269
Breuer-Hering reflex legal definition of Breuer-Hering reflexBreuer-Hering reflex legal definition of Breuer-Hering reflex
Bretylium. *Bretylium compounds. *Bretylium tosilate. *Bretylium tosylate. *Bretylol. *Bretzel. *Bretzel. *Bretzel. *Breuer ...
https://legal-dictionary.thefreedictionary.com/Breuer-Hering+reflex
MEDICAMEDICA
Ventricular Fibrillation--drug therapy;Methoxamine--therapeutic use;Bretylium Compounds--therapeutic use;Academic Dissertations ... Comparing the effectiveness of methoxamine and bretylium tosylate on electrically-induced ventricular fibrillation in dogs ...
http://digital.library.musc.edu/cdm/search/searchterm/perfusion
bretylium tosylate (CHEBI:3173)bretylium tosylate (CHEBI:3173)
... chemical compounds. ... Find compounds which contain this structure. *Find compounds ... bretylium tosylate (CHEBI:3173) has part bretylium (CHEBI:3172) bretylium tosylate (CHEBI:3173) has role adrenergic antagonist ... bretylium tosylate (CHEBI:3173) has role anti-arrhythmia drug (CHEBI:38070) bretylium tosylate (CHEBI:3173) has role ... bretylium tosylate (CHEBI:3173) is a organosulfonate salt (CHEBI:64382) bretylium tosylate (CHEBI:3173) is a quaternary ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3173
Efferent limb of the coronary vasoconstrictor reflex elicited by distension of the descending colon in anesthetized dogs<...Efferent limb of the coronary vasoconstrictor reflex elicited by distension of the descending colon in anesthetized dogs<...
Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ...
https://moh-it.pure.elsevier.com/en/publications/efferent-limb-of-the-coronary-vasoconstrictor-reflex-elicited-by-
Breuer-Hering Inflation Reflex - How is Breuer-Hering Inflation Reflex abbreviated?Breuer-Hering Inflation Reflex - How is Breuer-Hering Inflation Reflex abbreviated?
Bretylium. *Bretylium compounds. *Bretylium tosilate. *Bretylium tosylate. *Bretylol. *Bretzel. *Bretzel. *Bretzel. *Breuer ...
https://acronyms.thefreedictionary.com/Breuer-Hering+Inflation+Reflex
BrettspielWelt - What does BrettspielWelt stand for? The Free DictionaryBrettspielWelt - What does BrettspielWelt stand for? The Free Dictionary
Bretylium. *Bretylium compounds. *Bretylium tosilate. *Bretylium tosylate. *Bretylol. *Bretzel. *Bretzel. *Breuer. *Breuer ...
http://acronyms.thefreedictionary.com/BrettspielWelt
NAVER Academic > Search...NAVER Academic > Search...
Adrenergic beta-Antagonists, Animals, Atropine, pharmacology, Bretylium Compounds, Electric Stimulation, Guinea Pigs, In Vitro ...
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VARDENAFIL ODT | Compounding Pharmacy - Empower PharmacyVARDENAFIL ODT | Compounding Pharmacy - Empower Pharmacy
111. Bretylol® (bretylium) package insert. Manati, Puerto Rico: Du pont Pharmaceuticals; 1991 Jan. ... 110 bretylium,111 cisapride,112 dofetilide,113 dronedarone,114 grepafloxacin,115 halofantrine,116 levomethadyl,117 mesoridazine ... 146161 Grapefruit juice contains a furano-coumarin compound, 6,7-dihydroxybergamottin that inhibits CYP3A4 in enterocytes in ...
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NAVER Academic > Search...NAVER Academic > Search...
Action Potentials, drug effects, Animals, Anti-Arrhythmia Agents, pharmacology, Bretylium Compounds, Dogs, Heart Conduction ... Animals, Bicyclo Compounds, Heterocyclic, Buprenorphine, pharmacology, Butorphanol, Cycloparaffins, Discrimination Learning, ...
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METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS - Presidents and Fellows of Harvard CollegeMETHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS - Presidents and Fellows of Harvard College
Inhibition of voltage-gated ion channels by the second compound identifies the second compound as a compound that is useful for ... bretylium, lifarizine, lamotrigine, flunarizine, and fluspirilene. 10. 10.-12. (canceled) 13. The method of claim 1, wherein ... to compound (B). Thus, linking of compound (A) to compound (B) is achieved by covalent means, involving bond formation with one ... In formula (XII), G1 is a bond between compound (A) and the linker; G2 is a bond between the linker and compound (B); Z1, Z2, Z ...
http://www.freepatentsonline.com/y2011/0086818.html
Benzylammonium Compounds | Harvard Catalyst Profiles | Harvard CatalystBenzylammonium Compounds | Harvard Catalyst Profiles | Harvard Catalyst
Benzylammonium Compounds. *Ambenonium Chloride. *Benzalkonium Compounds. *Benzethonium. *Bephenium Compounds. *Bretylium ... "Benzylammonium Compounds" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... QUATERNARY AMMONIUM COMPOUNDS based on BENZYLAMINES with the general formula phenyl-CN+R3. ... This graph shows the total number of publications written about "Benzylammonium Compounds" by people in Harvard Catalyst ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Benzylammonium%20Compounds
Bretylium tosylate | definition of bretylium tosylate by Medical dictionaryBretylium tosylate | definition of bretylium tosylate by Medical dictionary
What is bretylium tosylate? Meaning of bretylium tosylate medical term. What does bretylium tosylate mean? ... Looking for online definition of bretylium tosylate in the Medical Dictionary? bretylium tosylate explanation free. ... bretylium tosylate. bretylium tosylate. [britil′ē·əm] an antiarrhythmic agent. indication It is prescribed in the treatment of ... bretylium tosylate. A drug used to help to restore normal heart rhythm in the form of cardiac arrest known as VENTRICULAR ...
https://medical-dictionary.thefreedictionary.com/bretylium+tosylate
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
Bretylium Compounds D2.675.276.175 Bretylium Tosylate D2.675.276.175.150 Brimonidine Tartrate D3.438.857.70 D3.633.100.857.70 ... Heterocyclic Compounds with 4 or More Rings D3.549 D3.633.400 (Replaced for 2016 by Heterocyclic Compounds, 4 or More Rings) ... Bicyclo Compounds, Heterocyclic D2.455.426.100.80.85 D3.438.260 D4.75.80.875 (Replaced for 2016 by Bridged Bicyclo Compounds, ... Heterocyclic Compounds, 2-Ring D3.438 D3.633.100 Heterocyclic Compounds, 3-Ring D3.494 D3.633.300 Heterotrophic Processes ...
http://decs2019.bvsalud.org/I/mnchg2017.txt
Betalains | Harvard Catalyst Profiles | Harvard CatalystBetalains | Harvard Catalyst Profiles | Harvard Catalyst
Bethanechol Compounds. *Bis-Trimethylammonium Compounds. *Bretylium Compounds. *Butylscopolammonium Bromide. *Cetrimonium ... Compounds derived from TYROSINE via betalamic acid, including BETAXANTHINS and BETACYANINS. They are found in the ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Betalains
Toremifene Capsules | Empower Pharmacy | Compounding PharmacyToremifene Capsules | Empower Pharmacy | Compounding Pharmacy
... bretylium, cisapride, dofetilide, dronedarone, grepafloxacin, halofantrine, levomethadyl, mesoridazine, pimozide, probucol, ... Empower delivers an expansive compounded drug formulary across multiple areas of treatment that address what is important to ... Empower delivers an expansive compounded drug formulary across multiple areas of treatment that address what is important to ... Empower is an industry leading compounding pharmacy and outsourcing facility with an 11 year history of excellence and ...
https://www.empowerpharmacy.com/drugs/toremifene-citrate-capsules
Electric Countershock | The Chopra LibraryElectric Countershock | The Chopra Library
Bretylium Compounds. Defibrillators, Implantable. Dose-Response Relationship, Drug. Electric Conductivity. Electric ... The effects of antiarrhythmics, such as bretylium, or calcium antagonists, such as verapamil, nifedipine, or diltiazem on ... METHODS AND RESULTS: The effects of bretylium and verapamil on the energy requirements for ventricular defibrillation threshold ...
http://isharonline.org/tags/electric-countershock
Choline/pharmacologyCholine/pharmacology
Animals , Benzyl Compounds/pharmacology , Bretylium Compounds/pharmacology , Choline/pharmacology , Cold Temperature , ... Animals , Bretylium Compounds/pharmacology , Choline/pharmacology , Guanethidine/pharmacology , Guinea Pigs , Ileum/drug ...
https://search.bvsalud.org/gim/?lang=en&q=mh:Choline/pharmacology
Antiarrhythmic agent - WikipediaAntiarrhythmic agent - Wikipedia
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, ... Sympatholytic drugs (drugs blocking the effects of the sympathetic nervous system): examples included bretylium and adrenergic ... bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant and dronedarone. Class IV agents are slow non- ...
https://en.wikipedia.org/wiki/Antiarrhythmic_agent
Bretylium - Cardiac Output - ALPF Medical ResearchBretylium - Cardiac Output - ALPF Medical Research
Bretylium. Sat, 07 Jul 2012 , Cardiac Output Bretylium tosylate has a unique mode of action. It concentrates in the terminal ... Bretylium also has a unique action in that it may cause chemical cardioversion of ventricular fibrillation or facilitate ... Natural Compounds * Vital Signs * Urinary Tract Collecting System * Clinical Features * Situ Hybridization ...
https://www.alpfmedical.info/cardiac-output/bretylium.html
Hemicholinium 3 | REACHHemicholinium 3 | REACH
Bethanechol Compounds. *Bis-Trimethylammonium Compounds. *Bretylium Compounds. *Butylscopolammonium Bromide. *Cetrimonium ...
https://reach.sickkids.ca/display/14872
TosylateAmiodaroneAmmonium compoundsLidocaineVentricular fibrillationHypotensionNorepinephrinePathwaysDrugsTetracycline compoundGuanethidineChemicalDronedaronePharmaceuticalCalciumReflexDrugSignificantlySerotoninMechanismActiveAcidAgentsFormEffectsGenericProductsAdministrationYear
Tosylate8
  • When do Bretylium Tosylate In Dextrose 5% patents expire, and when can generic versions of Bretylium Tosylate In Dextrose 5% launch? (drugpatentwatch.com)
  • Bretylium Tosylate In Dextrose 5% is a drug marketed by Abbott , B Braun , Baxter Hlthcare , and Hospira Inc . and is included in four NDAs. (drugpatentwatch.com)
  • The generic ingredient in BRETYLIUM TOSYLATE IN DEXTROSE 5% is bretylium tosylate . (drugpatentwatch.com)
  • Additional details are available on the bretylium tosylate profile page. (drugpatentwatch.com)
  • The tosylate salt of bretylium. (ebi.ac.uk)
  • Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of catecholamines from the sympathetic postganglionic neurons. (elsevier.com)
  • Bretylium tosylate has a unique mode of action. (alpfmedical.info)
  • EFS-dependent contractions had ABT-888 been virtually abolished from the sympathetic nerve obstructing agent bretylium tosylate (3 10?5 M) and by the alpha-adrenergic antagonist terazosin (10?6 M), confirming these responses are neuronal in origin and adrenergic in character (data not demonstrated). (conferencedequebec.org)
Amiodarone2
  • Lidocaine and prilocaine should be used with caution with anti-arrhythmic drugs like amiodarone ( Cordarone ), sotalol ( Betapace ), bretylium, and dofetilide ( Tikosyn ) because of increased risk developing abnormal heart rate and rhythm. (medicinenet.com)
  • 6 Amiodarone is deethylated to an active metabolite desethyl-amiodarone, concentrations of which exceed those of the parent compound during long-term therapy. (ahajournals.org)
Ammonium compounds1
  • Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. (drugbank.ca)
Lidocaine1
  • Dysrhythmias unresponsive to sodium bicarbonate therapy/hyperventilation may respond to lidocaine, xenical buy now bretylium or phenytoin. (ontheotherhandnails.com)
Ventricular fibrillation1
  • Bretylium also has a unique action in that it may cause chemical cardioversion of ventricular fibrillation or facilitate cardioversion of ventricular fibrillation refractory to d.c. cardioversion. (alpfmedical.info)
Hypotension1
  • 13. A method of treating sympathetically maintained pain in peripheral tissues comprising topically administering to a patient a compound other than guanethidine or clonidine effective to treat peripheral sympathetically maintained pain at the site of treatment by blocking the effect of norepinephrine on nociceptor terminals, without systemic side effects of postural hypotension, headache, tachycardia, or nasal stuffiness. (google.com)
Norepinephrine2
  • Soon after its development, it was shown that iproniazid and similar chemical compounds slowed the breakdown of the monoamines norepinephrine (NE), serotonin (5-HT), and dopamine (DA) via inhibition of the mitochondrial enzyme monoamine oxidase-hence this class became known as monoamine oxidase inhibitors (MAOIs). (ontheotherhandnails.com)
  • Reboxetine (10 - 7 M) and cocaine (10 - 5 M) prevented the inhibitory action of bretylium (10 - 6 M). Reboxetine (10 - 8 -10 - 5 M), desipramine (10 - 7 -10 - 4 M), and cocaine (10 - 6 -10 - 5 M) increased the stimulation-evoked [ 3 H]norepinephrine release. (aspetjournals.org)
Pathways1
  • In the light of the different complexity of the two pathways at the plasma membrane level, and the non-toxic and reversible behavior of the drug, it is suggested that the bretylium induced sustained membrane hyperpolarization is responsible for the observation. (elsevier.com)
Drugs3
  • Persons who have an unconscious psychological need to be penicillin-susceptible, aqueous penicillin g cefepime gatifloxacin piperacillin cefotaxime imipenem-cilastatin quinupristin-cefotetan levofloxacin dalfopristin cefoxitin linezolid trimethoprim-ceftazidime sulfamethoxazole antihypertensives diazoxide methyldopa nitroprusside antiarrhythmic agents bretylium digoxin procainamide miscellaneous drugs ranitidine pancuronium table. (bac.edu)
  • For example, although non-steroid anti-inflammatory drugs (NSAIDs) are a class of compounds which are widely used for the treatment of inflammation, pain and fever, NSAIDs (e.g., aspirin, ibuprofen and ketoprofen) can cause gastrointestinal ulcers, a side-effect that remains the major limitation to the use of NSAIDs (see, for example, J. L. Wallace, in Gastroenterol. (justia.com)
  • A continuously challenging goal in the development of therapeutically useful drugs is to synthesize biologically active compounds that penetrate cells. (justia.com)
Tetracycline compound1
  • The invention pertains to methods for treating chronic lung disorders by administering a tetracycline compound, keflex 500mg dosage such as those described herein. (thatgirlwithwholeheart.com)
Guanethidine1
  • Chemical sympathectomy using IVRA with agents such as guanethidine or bretylium may last up to 5 days, as compared with local anesthetic blocks, which typically provide analgesia lasting only several hours. (nysora.com)
Chemical1
  • Somehow I get the distinct feeling that "Drug X" isn't a chemical compound. (roguemedic.com)
Dronedarone1
  • Related newer compounds, such as dronedarone, may have similar efficacy but a reduced rate of side-effects. (bionity.com)
Pharmaceutical1
  • Empower is an industry leading compounding pharmacy and outsourcing facility with an 11 year history of excellence and innovation in pharmaceutical compounding. (empowerpharmacy.com)
Calcium1
  • The effects of antiarrhythmics, such as bretylium, or calcium antagonists, such as verapamil, nifedipine, or diltiazem on internal defibrillation efficacy have been inconsistent or are unknown. (isharonline.org)
Reflex1
  • Erotism see under directional pattern, stereotypical example, chest symptoms of approximants: Semivowels such substance that different types of an organic compound] myostatic reflex. (rainierfruit.com)
Drug2
  • There are three drug master file entries for this compound. (drugpatentwatch.com)
  • Empower delivers an expansive compounded drug formulary across multiple areas of treatment that address what is important to both prescribers and patients: cost, convenience, compliance, and confidence in quality. (empowerpharmacy.com)
Significantly1
  • It has been demonstrated that bretylium, a quaternary ammonium ion, can significantly inhibit the first pathway at the same dose range that stimulates cell activation through the IL-2 receptor system. (elsevier.com)
Serotonin1
  • An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. (selfdecode.com)
Mechanism1
  • The aim of this study was to further investigate the mechanism of cell response to the 8b compound. (statescale.cf)
Active1
  • Delivery is usually effected by dissolution, degradation or disintegration of an excipient in which the active compound is formulated. (ambercann.com)
Acid3
  • Compounds derived from TYROSINE via betalamic acid, including BETAXANTHINS and BETACYANINS. (harvard.edu)
  • Weak electrolytes are conjugate forms, or Brönsted-Lowry acid and base forms, of the same compound that differ only by presence or absence, respectively, of protons. (compoundingtoday.com)
  • Increase in the penetration of tracer compounds into the rat brain during 2-methyl-4-chlorophenoxyacetic acid (MCPA) intoxication. (storysteel.gq)
Agents1
  • SINEQUAN® (doxepin hydrochloride) is one of a class of psychotherapeutic agents known as dibenzoxepin tricyclic compounds. (rxlist.com)
Form1
  • He was able to explain multiple proportions by assuming that an atom of nitrogen could react with one, two, or more atoms of oxygen to form a series of compounds. (findbinaryoption.com)
Effects1
  • METHODS AND RESULTS: The effects of bretylium and verapamil on the energy requirements for ventricular defibrillation threshold (DFT) were determined in 92 open-chest anesthetized pigs. (isharonline.org)
Generic1
  • S albuterol, which are conjugated compounds and generic levothyroxine buy wilson and raloxifene, usp. (creativephl.org)
Products1
  • We intend to pursue the removal of these unapproved compounded products from commercial distribution. (ptcommunity.com)
Administration1
  • Compatibility, stability, and incompatibility are subjects of which a pharmacist must be thoroughly educated to protect patients from harm resulting from the administration of an improperly compounded or stored preparation. (compoundingtoday.com)
Year1
  • This graph shows the total number of publications written about "Benzylammonium Compounds" by people in Harvard Catalyst Profiles by year, and whether "Benzylammonium Compounds" was a major or minor topic of these publication. (harvard.edu)
Quaternary Ammonium Compounds - DrugBank
Quaternary Ammonium Compounds - DrugBank (drugbank.ca)
MEDICA
MEDICA (digital.library.musc.edu)
Bretylium tosylate (CHEBI:3173)
Bretylium tosylate (CHEBI:3173) (ebi.ac.uk)
NAVER Academic > Search...
NAVER Academic > Search... (academic.naver.com)
VARDENAFIL ODT | Compounding Pharmacy - Empower Pharmacy
VARDENAFIL ODT | Compounding Pharmacy - Empower Pharmacy (empowerpharmacy.com)
Benzylammonium Compounds | Harvard Catalyst Profiles | Harvard Catalyst
Benzylammonium Compounds | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)
Toremifene Capsules | Empower Pharmacy | Compounding Pharmacy
Toremifene Capsules | Empower Pharmacy | Compounding Pharmacy (empowerpharmacy.com)
Electric Countershock | The Chopra Library
Electric Countershock | The Chopra Library (isharonline.org)
Bretylium - Cardiac Output - ALPF Medical Research
Bretylium - Cardiac Output - ALPF Medical Research (alpfmedical.info)
Hemicholinium 3 | REACH
Hemicholinium 3 | REACH (reach.sickkids.ca)
Medical Graduate: Pharmacology Mnemonics
Medical Graduate: Pharmacology Mnemonics (medicalgraduate.blogspot.com)
Sudafed vs Mucinex - Uses, Side Effects, Differences - Your Health Remedy
Sudafed vs Mucinex - Uses, Side Effects, Differences - Your Health Remedy (yourhealthremedy.com)
Tofranil (Imipramine): Side Effects, Interactions, Warning, Dosage & Uses
Tofranil (Imipramine): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
Laboratory Values and Interpretation - A Nurse's Ultimate Guide - NurseBuff
Laboratory Values and Interpretation - A Nurse's Ultimate Guide - NurseBuff (nursebuff.com)
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