Bretylium CompoundsBretylium Tosylate: An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.Sympatholytics: Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.AmidinesPharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Pempidine: A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.Pentolinium Tartrate: A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.Hexamethonium Compounds: Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.Allosteric Regulation: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.Allosteric Site: A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Ontario: A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.N-Methylscopolamine: A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.Gallamine Triethiodide: A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.Adrenergic alpha-2 Receptor Agonists: Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.Vaginismus: Recurrent or persistent involuntary SPASM of the outer muscles of the VAGINA, occurring during vaginal penetration.Vulvitis: Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.Vulvar Vestibulitis: Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area.Dyspareunia: Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.Enzyme Activators: Compounds or factors that act on a specific enzyme to increase its activity.Sexual Dysfunctions, Psychological: Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)Cystitis, Interstitial: A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.Antidepressive Agents, Tricyclic: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Antidepressive Agents: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.Diabetes Insipidus: A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Hypernatremia: Excessive amount of sodium in the blood. (Dorland, 27th ed)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Receptors, Adrenergic, beta: One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.beta-Adrenergic Receptor Kinases: G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS.Receptors, Adrenergic: Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Alprenolol: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. (1/124)

We examined the effect of stress on colonic epithelial physiology, the role of corticotropin-releasing hormone (CRH), and the pathways involved. Rats were restrained or injected intraperitoneally with CRH or saline. Colonic segments were mounted in Ussing chambers, in which ion secretion and permeability (conductance and probe fluxes) were measured. To test the pathways involved in CRH-induced changes, rats were pretreated with hexamethonium, atropine, bretylium, doxantrazole, alpha-helical CRH-(9-41) (all intraperitoneally), or aminoglutethimide (subcutaneously). Restraint stress increased colonic ion secretion and permeability to ions, the bacterial peptide FMLP, and horseradish peroxidase (HRP). These changes were prevented by alpha-helical CRH-(9-41) and mimicked by CRH (50 microgram/kg). CRH-induced changes in ion secretion were abolished by alpha-helical CRH-(9-41), hexamethonium, atropine, or doxantrazole. CRH-stimulated conductance was significantly inhibited by alpha-helical CRH-(9-41), hexamethonium, bretylium, or doxantrazole. CRH-induced enhancement of HRP flux was significantly reduced by all drugs but aminoglutethimide. Peripheral CRH reproduced stress-induced colonic epithelial pathophysiology via cholinergic and adrenergic nerves and mast cells. Modulation of stress responses may be relevant to the management of colonic disorders.  (+info)

Preventing ventricular fibrillation by flattening cardiac restitution. (2/124)

Ventricular fibrillation is the leading cause of sudden cardiac death. In fibrillation, fragmented electrical waves meander erratically through the heart muscle, creating disordered and ineffective contraction. Theoretical and computer studies, as well as recent experimental evidence, have suggested that fibrillation is created and sustained by the property of restitution of the cardiac action potential duration (that is, its dependence on the previous diastolic interval). The restitution hypothesis states that steeply sloped restitution curves create unstable wave propagation that results in wave break, the event that is necessary for fibrillation. Here we present experimental evidence supporting this idea. In particular, we identify the action of the drug bretylium as a prototype for the future development of effective restitution-based antifibrillatory agents. We show that bretylium acts in accord with the restitution hypothesis: by flattening restitution curves, it prevents wave break and thus prevents fibrillation. It even converts existing fibrillation, either to a periodic state (ventricular tachycardia, which is much more easily controlled) or to quiescent healthy tissue.  (+info)

Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip. (3/124)

We tested the hypothesis that a reduction in sympathetic tone to exercising forearm muscle would increase blood flow, reduce muscle acidosis, and attenuate reflex responses. Subjects performed a progressive, four-stage rhythmic handgrip protocol before and after forearm bier block with bretylium as forearm blood flow (Doppler) and metabolic (venous effluent metabolite concentration and (31)P-NMR indexes) and autonomic reflex responses (heart rate, blood pressure, and sympathetic nerve traffic) were measured. Bretylium inhibits the release of norepinephrine at the neurovascular junction. Bier block increased blood flow as well as oxygen consumption in the exercising forearm (P < 0.03 and P < 0.02, respectively). However, despite this increase in flow, venous K(+) release and H(+) release were both increased during exercise (P < 0.002 for both indexes). Additionally, minimal muscle pH measured during the first minute of recovery with NMR was lower after bier block (6.41 +/- 0.08 vs. 6.20 +/- 0.06; P < 0.036, simple effects). Meanwhile, reflex effects were unaffected by the bretylium bier block. The results support the conclusion that sympathetic stimulation to muscle during exercise not only limits muscle blood flow but also appears to limit anaerobiosis and H(+) release, presumably through a preferential recruitment of oxidative fibers.  (+info)

Ciliary ganglion stimulation. II. Neurogenic, intraocular pathway for excitatory effects on aqueous humor production and outflow. (4/124)

Data obtained suggest that preganglionic stimulation of the ciliary ganglion produces an increase of aqueous humor formation and of facility of outflow "C" through the following neurogenic pathway: (1) the preganglionic fibers synapse in the ciliary ganglion as evidenced by depression of the response with nicotine applied topically to the ganglion. (2) The impulse proceeds to the equivalent of an intraocular interneuron which can be blocked by low concentrations of atropine and has been previously identified as being an E-2 receptor site. (3) From the interneuron, activity is ultimately exerted without further synapse on alpha-adrenergic receptors through the release of norepinephrine from the neuronal terminals. The adrenergic mechanism of action is supported by the inhibition of the responses by phenoxybenzamine, bretylium, and guanethidine. Constriction of efferent ciliary process blood vessels by neuron-released norepinephrine seems to be the end effect responsible for the increased production of aqueous humor. The site of the end response to increase "C" is unclear.  (+info)

Effect of destruction of the posterior pituitary on the diuresis from left atrial receptors. (5/124)

1. In anaesthetized dogs, stimulation of atrial receptors after destruction of the pituitary gland results in a diuresis. This response was not abolished by the administration of bretylium tosylate and was also observed in a surgically denervated kidney. 2. The diuresis is qualitatively similar to that observed in anaesthetized dogs with intact pituitary glands. 3. It is concluded that the diuresis which results from stimulation of the left atrial receptors is mediated by a blood-borne agent which is not the antidiuretic hormone.  (+info)

Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats. (6/124)

Acute cold exposure-induced activation of gastric myenteric neurons in conscious rats was examined on longitudinal muscle-myenteric plexus whole mount preparations. Few Fos-immunoreactive (IR) cells (<1/ganglion) were observed in 24-h fasted rats semirestrained at room temperature. Cold exposure (4 degrees C) for 1-3 h induced a time-related increase of Fos-IR cells in corpus and antral myenteric ganglia with a maximal plateau response (17 +/- 3 and 18 +/- 3 cells/ganglion, respectively) occurring at 2 h. Gastric vagotomy partly prevented, whereas bilateral cervical vagotomy completely abolished, Fos expression in the myenteric cells induced by cold exposure (2 h). Hexamethonium (20 mg/kg) also prevented 3-h cold exposure-induced myenteric Fos expression by 76-80%, whereas atropine or bretylium had no effect. Double labeling revealed that cold (3 h)-induced Fos-IR myenteric cells were mainly neurons, including a substantial number of choline acetyltransferase-containing neurons and most NADPH-diaphorase-positive neurons. These results indicate that acute cold exposure activates cholinergic as well as nitrergic neurons in the gastric myenteric ganglia through vagal nicotinic pathways in conscious rats.  (+info)

Influence of cocaine and sodium on bretylium uptake by reserpine-treated guinea-pig left atrium. (7/124)

1 The effects of cocaine and sodium on bretylium uptake into sympathetic nerve terminals were investigated in the reserpine-treated guinea-pig left atrium. The ability of bretylium pretreatment to increase the retention of noradrenaline was used as an index of bretylium uptake. Such increased retention has been assessed both by direct measurement and by the ability of tyramine to produce an inotropic response. 2 The restoration of the response to tyramine after incubation with noradrenaline was abolished when the atrium was pretreated with bretylium in the presence of cocaine. When bretylium was added before cocaine, or when alpha-methyl-noradrenaline (not a substrate for monoamine oxidase) was used for incubation, the responses to tyramine were restored in the normal way. 3 Bretylium greatly enhanced the retention of [3-H]-noradrenaline; when bretylium was added in the presence of cocaine, [3-H]-noradrenaline retention was severely impaired. 4 Pretreatment with bretylium in a low-sodium (25 mM) or sodium-free medium significantly decreased the retention of [3-H]-noradrenaline, as compared with the control. 5 Potassium deprivation did not modify the enhanced retention of [3-H]-noradrenaline induced by bretylium pretreatment. 6 Bretylium was released from the nerve terminals by exposure of the preparation to a sodium-free medium or to a solution containing calcium 50 mM, leading to a considerable decrease in [3-H]-noradrenaline retention. 7 The results are consistent with the view that both cocaine and sodium deprivation block the uptake of bretylium by the adrenergic nerve terminals, and that bretylium is probably taken up by a mechanism similar to or identical with the uptake system for noradrenaline and other amines.  (+info)

Studies of uptake of the bretylium analogue, iodobenzyltrimethylammonium iodide, by non-primate, monkey and human hearts. (8/124)

Uptake of (+/-)-[3H]-noradrenaline, [14C]-bretylium and [125I]-o-iodobenzyltrimethylammonium iodide (RIBA) by rat heart was studied by the Langendorff technique. All three compounds showed significant uptake. 2 Corticosterone and 17-beta-oestradiol inhibited the uptake of all three compounds by rat heart, a finding consistent with extraneuronal uptake (uptake2). 3 [131I]-RIBA was injected intravenously into pigs and monkeys (M. speciosus). Myocardial samples taken from pigs killed 1 and 2 h after injection showed significant uptake. No significant uptake was found in myocardial samples of monkeys killed 10 min, 2 h and 24 h, respectively, after injection. 4 Four normal human volunteers received [125I]-RIBA intravenously and the image of the precordial area was followed by means of scintillation camera for the first 4 h after injection. In two of the subjects, the scintigrams were repeated at 22 and 23 h after injection, respectively. No evidence of myocardial uptake was observed. 5 These results suggest the possibility that man and at least one other primate species may differ from lower species with regard to uptake.  (+info)

*List of MeSH codes (D02)

... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ... bretylium compounds MeSH D02.675.276.175.150 --- bretylium tosylate MeSH D02.675.276.190 --- cetrimonium compounds MeSH D02.675 ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ...

*Antiarrhythmic agent

Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, ... Sympatholytic drugs (drugs blocking the effects of the sympathetic nervous system): examples included bretylium and adrenergic ... bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant and dronedarone. Class IV agents are slow non- ...

*Aconitum napellus

Like other species in the genus, A. napellus contains several poisonous compounds, including enough cardiac poison that it was ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ...

*List of adrenergic drugs

These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the ... Bethanidine Bretylium Guanadrel Guanazodine Guanclofine Guanethidine Guanoxan Oxidopamine (6-hydroxydopamine). ...
Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...
Bretylium (also bretylium tosylate) is an antiarrhythmic agent. It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is considered a class III antiarrhythmic. The dose is 5-10 mg/kg and side effects are high blood pressure followed by low blood pressure and ventricular ectopy. Originally introduced in 1959 for the treatment of hypertension. Its use as an antiarrhythmic for ventricular fibrillation was discovered and patented by Marvin Bacaner in 1969 at the University of Minnesota. The American Heart Association removed bretylium from their 2000 ECC/ACC guidelines due to its unproven efficacy and ongoing supply problems. Many have cited these supply problems as an issue of raw materials needed in the production of Bretylium. By the release of the AHA 2005 ECC/ACC guidelines there is no mention of Bretylium and it is virtually unavailable throughout most of the world. As ...
Bretylium tosylate (Bretylol) has recently been approved for parenteral use against resistant ventricular arrhythmias. The pharmacologic action of bretylium is complex, and its antiarrhythmic action differs significantly from other drugs. Bretylium is an adrenergic neuronal blocking agent taken up selectively at peripheral adrenergic nerve terminals, where it initially releases norepinephrine (sympathomimetic effect) and then produces adrenergic neuronal blockade. It has direct cardiac membrane effect to prolong action potential duration and effective refractory period but, unlike other membrane active antiarrhythmic agents, does not depress conduction velocity or automaticity. Bretylium increases ventricular fibrillation threshold and prevents the decrease in ventricular fibrillation threshold associated with myocardial ischemia. It does not depress myocardial contractility. Clinical studies have shown parenteral bretylium to be effective in suppressing ventricular arrhythmias, particularly ...
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician ...
RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether sorafenib tosylate is more effective when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with liver cancer.. PURPOSE: This randomized phase II trial is studying sorafenib tosylate to see how well it works when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with locally advanced, unresectable, or metastatic liver cancer. ...
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COA of Sorafenib Tosylate contains the actual results obtained from testing performed as part of quality control. View our Sorafenib Tosylate specific physical and chemical properties, and analytical data.
Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
During the cooling, BP increased in both subjects (young from 95/69 to 132/75 mmHg, old from 125/68 to 176/101 mmHg), the latter exhibiting a prominent rise in diastolic values after cooling. HRV parameters increased in both subjects during the cold exposure being modest in the younger subject as compared to the older one. Also, recovery from the cold in terms of HRV was faster in the younger subject. The present preliminary observations indicate that older age is coupled with altered HRV response to a mild whole‐body skin cooling ...
To 15.2 g vanillin (0.1 mol) a calculated amount of kalihydrat (probably KOH) was added and dissolved in 75 ml MeOH. 18 g methyl tosylate (0.1 mol) and heated on a water bath for 1.5 h to reflux. As soon as the the light yellow, clear solution starts boiling the potassium salt of methyl toluenesulfonic acid starts to precipitate. After 1.5 h everything is poured in about 300 ml of H2O. First there is a white emulsion which starts to separate a light yellow oil. The aqeuous solution and the oil is extracted exhaustive with Et2O, the organic phase is washed twice with 10 ml 5% aqeuous KOH to remove unreacted vanillin. The organic phase turns almost colourless, the alkaline solution is light yellow. The organic phase is washed with H2O, dried with freshly sulphate (probably MgSO4 or Na2SO4) and evaporated. The oily residue solidifies on cooling (melting point: 42-43°C ...
PRIMARY OBJECTIVES:. I. Two-year recurrence free survival (RFS).. SECONDARY OBJECTIVES:. I. One-year recurrence free survival. II. Overall survival (OS). III. Safety. IV. Impact of drug-drug interactions (i.e. immunosuppression agents). V. Impact of biomarkers (alpha-fetoprotein [AFP], protein-induced by vitamin K absence or antagonist II [PIVKA II]).. VI. Effects of therapy on wound healing. VII. Impact of hepatitis C viral recurrence.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive sorafenib tosylate orally (PO) twice daily (BID).. ARM II: Patients receive placebo PO BID.. In both arms treatment continues for 24 months in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 6 months for 2 years. ...
LY 2584702 tosylate | S6K1 inhibitor | LY 2779964 | LY2584702 | LY2779964 | CAS [1082949-68-5] - [1082949-67-4] | Axon 2464 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
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Guanethidine Sulfate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Guanethidine Sulfate is available on the Drugs.com website.
Drugs. The following drugs were used: bretylium tosylate (Burroughs Wellcome, Research Triangle Park, NC); (-)-cocaine hydrochloride (Merck, Darmstadt, Germany), desipramine hydrochloride (Ciba-Geigy AG, Basel, Switzerland); 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone (U-0521; The Upjohn Company, Kalamazoo, MI); (-)-norepinephrine hydrochloride (Sigma-Aldrich, St. Louis, MO); (-)-[7-3H] (N)norepinephrine hydrochloride (specific activity, 12.0-14.9 Ci/mmol; PerkinElmer Life Sciences, Boston, MA); pargyline hydrochloride (Abbott Laboratories, North Chicago, IL); and reboxetine hydrochloride, a racemic mixture of (-)-R,R-and (+)-S,S-(2-[α[2-ethoxyphenoxy]benzyl]-morpholine hydrochloride (synthesized in the Department of Medicinal Chemistry, H. Lundbeck A/S, Copenhagen, Denmark).. Stock solutions were prepared in twice-distilled water (bretylium, cocaine, desipramine, norepinephrine, [3H]norepinephrine, and pargyline). The stock solutions were diluted with physiological salt solution (PSS) to the ...
A full description of the terminal morphology of sympathetic postganglionic axons innervating the musculature of the gastrointestinal (GI) tract has not been available. Furthermore, common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of the techniques employed to distinguish the fibers and complicated by inconsistent findings generated with various methodologies. Thus, the present experiment used modern neural tracer techniques to provide high-resolution labeling of sympathetic fibers projecting to the smooth muscle wall of the GI tract. Fischer 344 rats (N = 50) received injections of dextran biotin into the left celiac and superior mesenteric ganglia. Nine days post-injection, the animals were euthanized and their stomachs and small intestines were processed to visualize the postganglionic axons. Myenteric neurons were counterstained with Cuprolinic Blue. Individual sympathetic arbors (n = 154) in the gut wall were
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A neurotransmitter produced and released by sympathetic postganglionic neurons to accelerate organ activity. Also produced in the brainstem and found in projections throughout the brain. Here, a hormone secreted by the adrenal medulla under the control of the sympathetic nervous system, which prepares the body for action. ...
Product Description Model NO.: hangzhou royall Customized: Non-Customized Suitable for: Elderly, Children, Adult Purity: |99% CAS: 475207-59-1 Grade Standard: Medicine Grade Shelf Life: 2years Standard: USP Ep Jp etc Appearance: White Powder Transport Package: by Sea, by Air, by Express Origin: Zhejiang, China Powder: Yes Certification: GMP, HSE, ISO 9001, USP, BP State: Solid Product Name: Sorafenib Tosylate Type: Antineoplastic Agents Assay: HPLC 99% Application: Pharma Intermediate Package: 1/5/10/20/25 Kg/Drum/CTN/Bag Trademark: royall Specification: 99%min HS Code: 42356122…
Looking for online definition of guanethidine sulphate in the Medical Dictionary? guanethidine sulphate explanation free. What is guanethidine sulphate? Meaning of guanethidine sulphate medical term. What does guanethidine sulphate mean?
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The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine.. The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues.. ...
misc{3a0513da-a6c0-4388-821c-b9474f344b0d, author = {Kuklane, Kalev and Vanggaard, Leif and Smolander, Juhani and Halder, Amitava and Lundgren Kownacki, Karin and Gao, Chuansi and Viik, Jari and Alametsä, Jarmo}, language = {eng}, note = {Conference Abstract}, pages = {48--48}, publisher = {International Society for Environmental Ergonomics}, series = {Environmental Ergonomics}, title = {Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male - a pre-study}, volume = {XVI}, year = {2015 ...
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Adding IV Amiodarone to the EMS Algorithm for Cardiac Arrest Due to VF/Pulseless VT Introduction Before the year 2000, the traditional antiarrhythmic agents (lidocaine, bretylium, magnesium sulfate, procainamide,
Kirksville, mo journal printing company, willard f. canada edsupply Nociception new understandings and observations. Hypotension should be reexamined to days after the proposed proprioceptive role, the fascia of the sij. She and her colleagues performed many studies corroborating this healthenhancing, life-prolonging effect in the differential diagnosis. In these statistical procedures, we set our confidence intervals for temperatures above c. Bretylium is no more than min first maintenance infusion mgkg infused over hr mg po qd or valacyclovir g orally bid days or younger than years are there social or occupational therapy, modalities, tens, braces and splints, injections, osteopathic manipulation, one has transgressed personal, family, andor group members expectations of resuscitation aids in penetration of the parietal cortex the primary catch-up series or as the obstruction of the. Did the manipulative procedures . The economic burden of mental health. Overcoming myths regarding the ...
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DESCRIPTION Integumentary system or skin is body skin and derivates. All of the fish body covered by skin except eyes (tranparently skin)
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Valbenazine, also known as NBI-98854 and MT-5199, is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines. NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients. These results support the phase 3 clinical trials of NBI-98854 now underway.
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Methods, formulations, and a system for improved iontophoretic administration of a drug, by, preferably, topical administration of a formulation containing an active vasodilator, rubefacient, or counterirritant agent such as capsaicin on the skin at the electrode site, or, iontophoretic administration of a vasodilator formulation or alpha blocker prior to iontophoretic administration of the drug.
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The present invention relates to 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone tosylate salt in crystalline and in solid forms, the method of making and using such crystals.
Norepinephrine is originally synthesized from tyrosine found in the extracellular fluid. Intracellularly transported tyrosine is then modified to norepinephrine which is packaged into vesicles and released following stimulation of the nerve terminal. Once released, synaptic norepinephrine is either degraded enzymatically or re-uptaken into the presynaptic terminal for recycling ...
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Its best to stay away from alcoholic beverages furosemide when you take Levitra, as it can aggravate several of your adverse effects. The signs and symptoms of BPH could be triggered by a tensing of the bigger muscle in the prostate gland avodart which blocks the passage of pee. Azithromycin celexa is an oral macrolide antibiotic made use of for the procedure of bacteria-induced infections. This is to make certain you are making use of the medicine albuterol for sale as it was recommended as component of your treatment. Your doctor requires to recognise if you are receiving treatment for heart rhythm disorder cheap tretinoin cream 0.25 or making use of such medicines as amiodarone, bretylium, disopyramide, procainamide, sotalol, quinidine, as these could interfere with Levaquin. Those negative side effects are not disappearing and need to be treated effectively. Ensure you ask your physician any sort of inquiries you have buy erythromycin without prescription before the procedure and be started ...
The duodenal epithelium secretes HC03-at higher rates than does the stomach (or more distal small intestine) and the duodenal secretion is currently accepted as the most important defence mechanism...
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drugs action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine. It may also inhibit the release of granules by decreasing norepinephrine. Side effects include orthostatic and exercise hypotension, sexual dysfunction (delayed or retrograde ejaculation), and diarrhea. Guanethidine is transported by uptake 1 into the presynaptic terminal transported by norepinephrine transporter (NET). (In this it competes with norepinephrine so can potentiate exogenously applied norepinephrine.) It becomes concentrated in norepinephrine transmitter vesicles, replacing norepinephrine in these vesicles. This leads to a gradual depletion of norepinephrine stores in the ...
branch and an active vasodilator branch [11]. Nonthermoregulatory reflexes, which include skin blood flow responses to changes in arterial and central venous pressure and exercise stresses, also operate through the two aforementioned branches of the sympathetic nervous system; however, the glabrous/ palmar skin operates only through the vasoconstrictor branch [10,11,41]. In the auto-regulation process, throughout a specific range of arterial blood pressure, steady-state blood flow is maintained at a fairly constant level [44]. Previous reports on cutaneous circulation has shown that, independent of neural control of blood flow, glabrous/palmar skin has the ability to buffer blood pressure oscillations and demonstrates a degree of dynamic auto-regulation. Conversely, nonglabrous or hairy skin has a diminished dynamic auto regulatory capacity [42]. We first tried to relate observations in the present study to some of the physiological findings reported earlier on the cutaneous responses to ...
Gefitinib 184475-35-2 White or off white crystalline powder ≥99% Sorafenib tosylate 475207-59-1 - Erlotinib Hcl 183319-69-9|Dasatinib monohydrate 863127-77-9 Details.
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Lesion is originally a Latin word meaning injury It is used for any abnormal tissue in the body Skin lesions include cysts moles or even warts They are
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The upper layer (integument) of the body is called skin. The body skin is an important system named Integumentary system, because it completes many important tasks of life.
When running in vivo experiments, it is imperative to keep arterial blood pressure and acid-base parameters within the normal physiological range. The aim of this investigation was to explore the consequences of anesthesia-induced acidosis on basal and PGE2-stimulated duodenal bicarbonate secretion. Mice (strain C57bl/6J) were kept anesthetized by a spontaneous inhalation of isoflurane. Mean arterial blood pressure (MAP), arterial acid-base balance, and duodenal mucosal bicarbonate secretion (DMBS) were studied. Two intra-arterial fluid support strategies were used: a standard Ringer solution and an isotonic Na2CO3 solution. Duodenal single perfusion was used, and DMBS was assessed by back titration of the effluent. PGE2 was used to stimulate DMBS. In Ringer solution-infused mice, isoflurane-induced acidosis became worse with time. The blood pH was 7.15-7.21 and the base excess was about -8 mM at the end of experiments. The continuous infusion of Na2CO3 solution completely compensated for the ...
Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M. and Rorsman, P. (2017). Functional identification of islet cell types by electrophysiological fingerprinting. J. R. Soc. Interface, 2017 14. Briant, L. J. B., OCallaghan, E. L., Champneys, A. R., and Paton, J. F. (2015). Respiratory modulated sympathetic activity: a putative mechanism for developing vascular resistance? J. Physiol. (Lond.), 593(24):5341-5360. Briant, L. J. B., Paton, J. F., Pickering, A. E., and Champneys, A. R. (2015). Modelling the vascular response to sympathetic postganglionic nerve activity. J. Theor. Biol., 371:102-116. Briant, L. J. B., Stalbovskiy, A. O., Nolan, M. F., Champneys, A. R., and Pickering, A. E. (2014). Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. J. Neurophysiol., 112(11):2756-2778. ...
Jan Marinis Bioglycolic Resurfacing Body Scrub offers superb retexturizing benefits for all body skin types and especially for skin that is dry or environmentally damaged. This scrub offers an aggressive but safe approach for reaching a noticeably improved level of body skin rejuvenation. This formulation enables patients to immediately address roughened or calloused areas while enhancing overall smoothness and tone. It immediately and dramatically retexturizes, smooths and softens body skin.
Hydration is the foundation of healthy and radiant skin. Non-invasive, immediate long-term results. Cells cant function optimally when they are not fully hydrated, often resulting in tissue damage. Dehydrated skin tissue suffers a loss of elasticity, resilience, tone, and texture. HydraFacial is a non-invasive treatment that detoxifies, rejuvenates, and protects the skin by applying a 6-step procedure, during which the skin is exfoliated to cleanse of impurities and dead cells, rehydrated, and nourished to replenish antioxidants, peptides, and hyaluronic acid. These vital nutrients help mitigate environmental damage, reduce appearance of lines and wrinkles, and restore volume and firmness of the skin for long-term results that can be seen and felt immediately ...
Q: I have had PHN for over more than ten years, it is affecting my left leg..the pains is still ongoing... I wonder if acupuncture can help?. A: As you might imagine we have been asked about this many times over the years; shingles can be a terribly distressing condition whose after-effects can persist for months or even years. The treatment of post herpetic pain is an area which has been heavily researched in China, as our factsheet. http://www.acupuncture.org.uk/a-to-z-of-conditions/a-to-z-of-conditions/herpes.html. says, but the quality of trials is not that great. There is a comprehensive systematic review of all available trials, but this was only announced last year and has not yet been published. We ourselves have treated many cases of shingles, and we have to be honest and say that there has been a significant number of cases where it has been very difficult indeed to reduce the pain, which as we are sure you know can be excruciating.. However, there is no point in being unduly ...
The rituals of burial in certain African cultures have also been responsible for the virus spreading in certain cases. The reason for this is the fact that certain rituals in Africa involve people attending the funeral touching the dead body. Since the virus has been known to survive for a number of days outside the body, it also remains on the skin of the person who is infected by it. Once a person attending the funeral of an infected person touches the dead bodys skin, all that remains for the transmission of the virus is for him to touch his mouth. This will also infect him with the Ebola virus. Following are certain additional ways of contracting the virus ...
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Digital Infrared Thermal Imaging (DITI) or thermography is a highly sensitive diagnostic test that scans and measures infrared radiation or heat at the bodys skin surface. These measurements are translated into an accurate graphic image called a thermogram. by Debra Voulgaris, DVM, MA, CVA, CCRP, CCT, Certified Tui-na Practitioner, Certified Veterinary Ozonotherapy It has been long […]. ...
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Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Bretylium Compounds - therapeutic use , Phentolamine - therapeutic use , Bretylium Compounds - adverse effects , Humans , ... bis-trimethylammonium compounds - administration & dosage (3) 3 Filter by. Remove filter. bis-trimethylammonium compounds - ... METHONIUM COMPOUNDS IN THE TREATMENT OF HYPERTENSION by WOLFFE, JOSEPH B and WALKOW, M.B and NAGLER, J. HERBERT and ANASTASI, ... Bis-Trimethylammonium Compounds - therapeutic use , Chlorthalidone - therapeutic use , Hexamethonium Compounds - therapeutic ...
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Patent USRE41998 - Compositions and methods of treatment of sympathetically maintained pain - Google PatentsPatent USRE41998 - Compositions and methods of treatment of sympathetically maintained pain - Google Patents

wherein the compound is selected from the group consisting of bretylium and methylapogalanthamine. ... wherein the c compound is a compound of Formula VII wherein R8 is hydrogen, R 9 and R 10 are alkoxy; R 11 is selected from the ... wherein the compound is a compound of Formula VI wherein R8 is hydrogen, R 9 and R 10 are alkoxy; R 11 is selected from the ... wherein the compound is a compound of Formula VI, wherein R9 and R 10 are methoxy; R 11 is selected from the group consisting ...
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MEDICAMEDICA

Ventricular Fibrillation--drug therapy;Methoxamine--therapeutic use;Bretylium Compounds--therapeutic use;Academic Dissertations ... Discovery of pharmacological compounds that stimulate renal mitochondrial biogenesis and restore kidney function ... Comparing the effectiveness of methoxamine and bretylium tosylate on electrically-induced ventricular fibrillation in dogs ...
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MEDICAMEDICA

Ventricular Fibrillation--drug therapy;Methoxamine--therapeutic use;Bretylium Compounds--therapeutic use;Academic Dissertations ... Comparing the effectiveness of methoxamine and bretylium tosylate on electrically-induced ventricular fibrillation in dogs ...
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List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ... bretylium compounds MeSH D02.675.276.175.150 --- bretylium tosylate MeSH D02.675.276.190 --- cetrimonium compounds MeSH D02.675 ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ...
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Action Potentials, drug effects, Animals, Anti-Arrhythmia Agents, pharmacology, Bretylium Compounds, Dogs, Heart Conduction ... Animals, Bicyclo Compounds, Heterocyclic, Buprenorphine, pharmacology, Butorphanol, Cycloparaffins, Discrimination Learning, ...
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Breuer-Hering reflex legal definition of Breuer-Hering reflexBreuer-Hering reflex legal definition of Breuer-Hering reflex

Bretylium. *Bretylium compounds. *Bretylium tosilate. *Bretylium tosylate. *Bretylol. *Bretzel. *Bretzel. *Bretzel. *Breuer ...
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BrettspielWelt - What does BrettspielWelt stand for? The Free DictionaryBrettspielWelt - What does BrettspielWelt stand for? The Free Dictionary

Bretylium. *Bretylium compounds. *Bretylium tosilate. *Bretylium tosylate. *Bretylol. *Bretzel. *Bretzel. *Breuer. *Breuer ...
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Quaternary Ammonium Compounds - DrugBankQuaternary Ammonium Compounds - DrugBank

Bretylium. Sodium/potassium-transporting ATPase subunit alpha-1. target. DB01199. Tubocurarine. Neuronal acetylcholine receptor ... Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with ... Bretylium. For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ... Typically employed as the cetylpyridinium chloride salt, this compound is commonly used as an active ingredient in various over ...
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US6214823B1 - Benzodiazepine derivatives as antiarrhythmic agents 
        - Google PatentsUS6214823B1 - Benzodiazepine derivatives as antiarrhythmic agents - Google Patents

This invention is concerned with novel compounds represented by structural formula I which are useful in the treatment of ... AAQOQKQBGPPFNS-UHFFFAOYSA-N Bretylium Chemical compound data:image/svg+xml;base64, ... 150000001875 compounds Chemical class 0 abstract claims description 47 * 239000003416 antiarrhythmic agent Substances 0 ... compounds. phenyl. Prior art date. 1997-10-17. Legal status (The legal status is an assumption and is not a legal conclusion. ...
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Patente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google PatentesPatente US6987129 - Compounds and methods for the treatment of urogenital disorders - Google Patentes

... estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG- ... using a variety of compounds, including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators, α- ... Compounds that deplete norepinephrine stores include, but are not limited to, reserpine, guanethidine and bretylium. Compounds ... In some embodiments, the at least two compounds are selected from the same class of compounds (e.g., both compounds are ...
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February 2018 - When do the patents on BRETYLIUM TOSYLATE IN DEXTROSE 5% expire, and when will generic BRETYLIUM TOSYLATE IN...February 2018 - When do the patents on BRETYLIUM TOSYLATE IN DEXTROSE 5% expire, and when will generic BRETYLIUM TOSYLATE IN...

There are three drug master file entries for this compound. Additional details are available on the bretylium tosylate profile ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-002. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-003. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ... BRETYLIUM TOSYLATE IN DEXTROSE 5%. bretylium tosylate. INJECTABLE;INJECTION. 019005-001. Apr 29, 1986. DISCN. No. No. ➠ Sign Up ...
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Efferent limb of the coronary vasoconstrictor reflex elicited by distension of the descending colon in anesthetized dogs<...Efferent limb of the coronary vasoconstrictor reflex elicited by distension of the descending colon in anesthetized dogs<...

Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ... Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of ...
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VARDENAFIL ODT | Compounding Pharmacy - Empower PharmacyVARDENAFIL ODT | Compounding Pharmacy - Empower Pharmacy

111. Bretylol® (bretylium) package insert. Manati, Puerto Rico: Du pont Pharmaceuticals; 1991 Jan. ... 110 bretylium,111 cisapride,112 dofetilide,113 dronedarone,114 grepafloxacin,115 halofantrine,116 levomethadyl,117 mesoridazine ... 146161 Grapefruit juice contains a furano-coumarin compound, 6,7-dihydroxybergamottin that inhibits CYP3A4 in enterocytes in ...
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METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS - Presidents and Fellows of Harvard CollegeMETHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS - Presidents and Fellows of Harvard College

Inhibition of voltage-gated ion channels by the second compound identifies the second compound as a compound that is useful for ... bretylium, lifarizine, lamotrigine, flunarizine, and fluspirilene. 10. 10.-12. (canceled) 13. The method of claim 1, wherein ... to compound (B). Thus, linking of compound (A) to compound (B) is achieved by covalent means, involving bond formation with one ... In formula (XII), G1 is a bond between compound (A) and the linker; G2 is a bond between the linker and compound (B); Z1, Z2, Z ...
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Bretylium tosylate | definition of bretylium tosylate by Medical dictionaryBretylium tosylate | definition of bretylium tosylate by Medical dictionary

What is bretylium tosylate? Meaning of bretylium tosylate medical term. What does bretylium tosylate mean? ... Looking for online definition of bretylium tosylate in the Medical Dictionary? bretylium tosylate explanation free. ... bretylium tosylate. bretylium tosylate. [britil′ē·əm] an antiarrhythmic agent. indication It is prescribed in the treatment of ... bretylium tosylate. A drug used to help to restore normal heart rhythm in the form of cardiac arrest known as VENTRICULAR ...
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Antiarrhythmic agent - WikipediaAntiarrhythmic agent - Wikipedia

Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, ... Sympatholytic drugs (drugs blocking the effects of the sympathetic nervous system): examples included bretylium and adrenergic ... bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant and dronedarone. Class IV agents are slow non- ...
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Bretylium - Cardiac Output - ALPF Medical ResearchBretylium - Cardiac Output - ALPF Medical Research

Bretylium. Sat, 07 Jul 2012 , Cardiac Output Bretylium tosylate has a unique mode of action. It concentrates in the terminal ... Bretylium also has a unique action in that it may cause chemical cardioversion of ventricular fibrillation or facilitate ... Natural Compounds * Vital Signs * Urinary Tract Collecting System * Clinical Features * Situ Hybridization ...
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Medical Graduate: Pharmacology MnemonicsMedical Graduate: Pharmacology Mnemonics

Bretylium. Ibutilide. Amiodarone. Sotalol. MAOIs: indications MAOIS:. Melancholic [classic name for atypical depression]. ... Auranofin and other gold compounds. Methotrexate. Penicillamine. Auranofin, aurothioglucose: category and indication. Aurum is ... Generic Aur- drugs (Auranofin, Aurothioglucose) are gold compounds.. · If didnt learn yet that golds indication is rheumatoid ...
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Sudafed vs Mucinex - Uses, Side Effects, Differences - Your Health RemedySudafed vs Mucinex - Uses, Side Effects, Differences - Your Health Remedy

Home Harmful Compounds Sudafed vs Mucinex - Uses, Side Effects, Differences. Sudafed vs Mucinex - Uses, Side Effects, ... bretylium;. *drugs for high blood pressure;. *linezolid;. *other meds for cough, cold, or allergy; ...
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Diprivan (propofol) dosing, indications, interactions, adverse effects, and moreDiprivan (propofol) dosing, indications, interactions, adverse effects, and more

Y-site: Amikacin, amphotericin B, atracurium, bretylium, calcium chloride, ceftazidime (?), ciprofloxacin, cisatracurium, ... Metabolized by hepatic conjugation to inactive compound. Elimination. Half-life: 40 min (initial); 24-72 hr (after 10-day ...
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Tofranil (Imipramine): Side Effects, Interactions, Warning, Dosage & UsesTofranil (Imipramine): Side Effects, Interactions, Warning, Dosage & Uses

Calcium phosphate, cellulose compounds, docusate sodium, iron oxides, magnesium stearate, polyethylene glycol, povidone, sodium ... Dysrhythmias unresponsive to sodium bicarbonate therapy/hyperventilation may respond to lidocaine, bretylium, or phenytoin. ... Patients with a known hypersensitivity to this compound should not be given the drug. The possibility of crosssensitivity to ... The concomitant use of monoamine oxidase inhibiting compounds is contraindicated. Hyperpyretic crises or severe convulsive ...
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Laboratory Values and Interpretation - A Nurses Ultimate Guide - NurseBuffLaboratory Values and Interpretation - A Nurse's Ultimate Guide - NurseBuff

Its the chemical compound that supplies energy to the cell.. Phosphorus plays an important role in the acid-base balance of ... Drugs that may decrease magnesium: Insulin, antiarrhythmic drugs, digoxin amiodarone, sotalol, quinidine, bretylium, ... Albumin is usually the first type of protein compound excreted in the urine whenever there is a kidney problem. Other types of ... When a bacterial infection is present in the urinary tract, the bacterial flora converts the urines nitrate compound to ...
more infohttps://www.nursebuff.com/laboratory-values-for-nurses/