A smooth, solid or cystic fibroepithelial (FIBROEPITHELIAL NEOPLASMS) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS. It consists of a fibrous stroma with nests of epithelial cells that sometimes resemble the transitional cells lining the urinary bladder. Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.
Neoplasms composed of more than one type of neoplastic tissue.
A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN II to form a component of the asymmetric unit membrane found in urothelial cells.
A uroplakin subtype that heterodimerizes with UROPLAKIN IB to form a component of the asymmetric unit membrane found in urothelial cells.
A rare teratoid tumor of the ovary composed almost entirely of thyroid tissue, with large follicles containing abundant colloid. Occasionally there are symptoms of hyperthyroidism. 5-10% of struma ovarii become malignant, the only absolute criterion for which is the presence of metastasis. (Dorland, 27th ed; Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Malignant Brenner tumors of the ovary and tumor markers: case reports. (1/18)

We investigated the tumor marker for malignant Brenner tumors, which had not been established because of the rarity and variable histological criteria. Representative areas of two cases of malignant Brenner tumor were investigated by means of the peroxidase-antiperoxidase method using monoclonal antibody to CA125 and CA72-4 antigen and the streptavidin-biotin immunoperoxidase complex method using monoclonal antibody to SCC antigen. Based on clinical course and immunohistochemical studies, serum CA125 and CA72-4 for Case 1 and SCC and CA72-4 for Case 2 were appropriate tumor markers for the establishment of the extent of tumor burden before treatment and to monitor the response to therapy. The discrepancy of the tumor markers of the two present cases is considered to be a reflection of the difference in the malignant component of these cases. However, serum CA72-4 was an appropriate tumor marker for both malignant Brenner tumors.  (+info)

Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (2/18)

Uroplakins are the characteristic integral membrane proteins in terminally differentiated, superficial urothelial asymmetric unit membrane. Brenner tumors of the ovary and Walthard cell nests of Fallopian tubes have been considered to represent urothelial differentiation in the female genital tract, but no definitive differentiation marker has been demonstrated supporting such a conclusion. An immunohistochemical analysis was performed to assess the expression of uroplakins in these lesions as well as in various benign and neoplastic lesions and normal tissues of the female genital tract. Focal expression of uroplakins was observed on the luminal surface of ovarian Brenner tumor cells forming microcysts in all 5 cases examined. In contrast, uroplakins were slightly expressed in only 1 of 12 cases of Walthard cell nests, even in the presence of microcyst formation. Uroplakins were not expressed in other benign or malignant lesions or normal tissues of the female genital tract. These results support the hypothesis that the Brenner tumor and possibly Walthard cell nests represent urothelial (transitional cell) differentiation.  (+info)

Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. (3/18)

Uroplakins are specific differentiation products of terminally differentiated superficial urothelial cells. We tested the value of a new commercially available monoclonal antibody against uroplakin III (clone AU 1) as a paraffin-reactive immunohistochemical marker for primary and metastatic urothelial carcinomas. The study cases included 67 urothelial carcinomas of the urinary tract (35 primary tumors, 32 metastases) and 318 nonurothelial carcinomas, as well as 5 benign Brenner tumors and 2 transitional cell carcinomas of the ovaries. Uroplakin III was detected in 21 (60%) of the primary urothelial carcinomas and 17 (53%) of the metastases, resulting in an overall sensitivity of 0.57. The studied Brenner tumors also were immunoreactive for uroplakin III. All other studied carcinomas were consistently uroplakin III-negative (specificity 1.00). We found the new monoclonal antibody AU 1 against uroplakin III to be a highly specific paraffin-reactive immunohistochemical marker for urothelial tumors with a moderate sensitivity for the identification of primary and metastatic urothelial carcinomas.  (+info)

Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. (4/18)

Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase in ovarian tumors and to assign clinicopathological correlations. Immunohistochemical analysis of matriptase was performed in tissue microarrays of 164 ovarian neoplasms including 84 serous adenocarcinomas, 23 mucinous adenocarcinomas, 10 endometrioid adenocarcinomas, six yolk sac tumors, 12 clear cell carcinomas, six dysgerminomas, eight granulosa cell tumors, four transitional cell carcinomas, five fibromas, and six Brenner tumors. All ovarian tumors except the fibromas and Brenner tumors showed significant expression of matriptase. The matriptase scores were significantly higher in the tumors than in their nontumor counterparts (304+/-26 for serous adenocarcinoma; 361+/-28 for mucinous adenocarcinoma; 254+/-17 for endometrioid adenocarcinoma; 205+/-19 for yolk sac tumor; 162+/-16 for clear cell carcinoma; 109+/-11 for dysgerminoma; 105+/-9 for granulosa cell tumor; and 226+/-18 for transitional cell carcinoma). Matriptase scores in serous adenocarcinoma were correlated with TNM stage and FIGO stage. Our findings demonstrate for the first time that matriptase is overexpressed in many malignant ovarian tumors. It may be a novel biomarker for diagnosis and treatment of malignant ovarian tumors.  (+info)

Expression and subcellular localization of maspin in human ovarian epithelial neoplasms: correlation with clinicopathologic features. (5/18)

BACKGROUND AND PURPOSE: Maspin is an inhibitor of serine proteinases with tumor suppressor activity that is down-regulated in breast and prostate cancer, but overexpressed in pancreatic carcinoma. However, there were very few published data regarding the role of maspin in ovarian carcinoma. The aim of the present study was to evaluate maspin expression in ovarian epithelial neoplasms and correlate its expression with some clinicopathologic parameters. MATERIAL AND METHODS: Seventy eight paraffin embedded ovarian specimens from patients with ovarian epithelial neoplasms comprised the material of this study. They included 18 benign, 14 low malignant potential (LMP) and 46 malignant epithelial ovarian neoplasms, in addition to seven specimens from normal ovarian tissues as a control. RESULTS: Immunohistochemical study of maspin expression using streptavidin biotin immunoperoxidase method revealed that, normal ovarian surface epithelium did not express maspin as well as benign serous and mucinous ovarian epithelial neoplasm. However, all benign Brenner ovarian tumors were maspin positive. On the other hand, 57.14% of LMP tumors showed weak maspin expression and 63% of malignant ovarian epithelial tumors showed maspin expression with 39.1% over expression. The two malignant Brenner tumors studied were maspin negative. There was a trend for maspin expression with high grade, high stage, bilateral tumors and tumors with metastasis. Tumors that showed maspin over-expression showed higher mitotic index (MI) (p=0.02). Invasive cancers were more likely to have predominantly cytoplasmic staining compared to LMP tumors. CONCLUSION: Maspin was expressed in a substantial proportion of ovarian tumors with poor prognostic parameters. These results may offer new insights regarding the role of maspin in ovarian cancer that may also impact diagnosis and treatment strategies. Moreover, variation in maspin expression between Brenner tumor and other epithelial surface ovarian tumors may indicate that the different histological types probably represent distinct disease entities and involve different molecular pathways.  (+info)

Brenner tumors of the ovary: sonographic and computed tomographic imaging features. (6/18)

OBJECTIVE: The purpose of this study was to describe the sonographic appearance of ovarian Brenner tumors with computed tomographic (CT) correlation. METHODS: Twenty-two female patients (age range, 32-78 years; mean, 58 years) with 25 ovarian Brenner tumors were identified from pathologic records from 1990 to 2005. Corresponding pathologic reports and images (17 sonographic and 14 CT) were reviewed independently. RESULTS: Tumors ranged in size from 0.3 to 12 cm (mean, 2.5 cm); all were benign. Sixteen (64%) of 25 were found incidentally. Eight (36%) of 22 patients had a total of 12 associated benign ovarian neoplasms (1 was contralateral); 3 patients had bilateral Brenner tumors. Eight (47%) of 17 tumors were not seen on sonography, and 5 (36%) of 14 were not seen on CT. Of the tumors seen on imaging, most were solid (67% on sonography and 78% on CT). Four tumors appeared at least partially cystic, of which 3 had coexistent cystic ovarian lesions. CONCLUSIONS: Brenner tumors are most often solid neoplasms found incidentally and frequently seen in association with other benign ovarian epithelial neoplasms.  (+info)

Transitional cell tumors of the ovary: a compact group with a heterogeneous histological and immunophenotypical pattern. (7/18)

A small percentage of ovarian neoplasms are transitional cell tumors, which proves to be a distinct group with various histological and immunohistochemical patterns. In this study, 13 archived formalin-fixed paraffin-embedded samples of transitional cell tumors of the ovary have been assessed using standard HE stain and the indirect tristadial ABC peroxidase IHC method for 11 antibodies (CA125, CK7, CEA, EMA, MNF116, CK20, Vim, ER, PgR, PCNA, Ki-67). More than 50% were malignant Brenner tumors. CA125 was positive in all malignant tumors (of Brenner type and transitional cell carcinomas), but not in benign and borderline tumors, while CK7 was positive in approximately 70% of all cases. These two antibodies have shown a high sensitivity and low specificity, but do not correlate to each other. PCNA was positive in the study batch with a mean value of 40% and Ki-67 with a mean value under 25%. A direct correlation statistically significant has been noted between the aforementioned proliferation factors and the tumor grade (r = 0.4, p = 0.05). The other markers were unspecific, with low sensitivity and independently of the histopathological type.  (+info)

Invasive lobular carcinoma of the breast diagnosed from an ovarian tumour. (8/18)

Invasive lobular carcinoma of breast is well known to be able to metastasise to unusual places, including the gastrointestinal and gynaecological tracts. However, it is very unusual for breast cancer to present in an ovarian Brenner tumour. This case highlights the diagnostic difficulties of patients presenting with unilateral ovarian masses, and the merits of thorough histological assessment of the entire pathological specimen despite the presence of one obvious pathological diagnosis.  (+info)

A Brenner tumor is a rare type of benign (non-cancerous) ovarian tumor that originates from the tissue that lines the ovary (the epithelium). These tumors are typically small, slow-growing, and asymptomatic, although in some cases they may cause abdominal discomfort or bloating.

Brenner tumors are composed of transitional cells, which are similar to the cells found in the urinary bladder. They are usually solid and contain areas of calcification (calcium deposits). While most Brenner tumors are benign, a small percentage may become malignant (cancerous) and spread to other parts of the body.

The exact cause of Brenner tumors is not known, but they are more common in older women and are often found incidentally during routine pelvic exams or imaging studies. Treatment typically involves surgical removal of the tumor, and the prognosis is generally excellent, especially for benign tumors.

Neoplasms are abnormal growths of cells or tissues in the body that can be benign (non-cancerous) or malignant (cancerous). When referring to "Complex and Mixed Neoplasms," it is typically used in the context of histopathology, where it describes tumors with a mixture of different types of cells or growth patterns.

A complex neoplasm usually contains areas with various architectural patterns, cell types, or both, making its classification challenging. It may require extensive sampling and careful examination to determine its nature and behavior. These neoplasms can be either benign or malignant, depending on the specific characteristics of the tumor cells and their growth pattern.

A mixed neoplasm, on the other hand, is a tumor that contains more than one type of cell or tissue component, often arising from different germ layers (the three primary layers of embryonic development: ectoderm, mesoderm, and endoderm). A common example of a mixed neoplasm is a teratoma, which can contain tissues derived from all three germ layers, such as skin, hair, teeth, bone, and muscle. Mixed neoplasms can also be benign or malignant, depending on the specific components of the tumor.

It's important to note that the classification and behavior of complex and mixed neoplasms can vary significantly based on their location in the body, cellular composition, and other factors. Accurate diagnosis typically requires a thorough examination by an experienced pathologist and may involve additional tests, such as immunohistochemistry or molecular analysis, to determine the appropriate treatment and management strategies.

Uroplakin Ia is not a medical term itself, but it is a component of uroplakins which are a group of proteins found in the urothelium, the tissue that lines the urinary tract. Uroplakins are involved in the formation of the asymmetric unit membrane (AUM) of the urothelial plaques, which are specialized structures on the apical surface of the superficial urothelial cells. These plaques provide a barrier function and protect the underlying tissues from various harmful substances in urine.

Uroplakin Ia is one of the four major uroplakins (UPIa, UPIb, UPII, and UPIII) that form heterodimers and then assemble into larger complexes to form the urothelial plaques. Specifically, Uroplakin Ia combines with Uroplakin Ib to form a heterodimer, which then associates with UPII and UPIII heterodimers to form a tetraspanin complex. These complexes are then incorporated into the AUM of the urothelial plaques.

Abnormalities in uroplakins have been associated with various urological disorders, including bladder cancer, interstitial cystitis, and chronic pelvic pain syndrome.

Uroplakin III is a protein that is a component of urothelial plaques, which are specialized structures found on the surface of urothelial cells in the urinary bladder. Urothelial plaques play an important role in maintaining the barrier function and permeability properties of the urothelium.

Uroplakin III is a member of the uroplakin family of proteins, which includes UPIa, UPII, UPIII, and UPIIIA. These proteins are synthesized in the endoplasmic reticulum and transported to the Golgi apparatus, where they form heterodimers that are then transported to the plasma membrane. At the plasma membrane, the heterodimers assemble into larger complexes called urothelial plaques.

Uroplakin III is a transmembrane protein with a molecular weight of approximately 27 kDa. It has been shown to play a role in the formation and stability of urothelial plaques, as well as in the regulation of ion transport across the urothelium. Mutations in the gene encoding Uroplakin III have been associated with certain bladder diseases, including interstitial cystitis/bladder pain syndrome and bladder cancer.

Struma ovarii is a rare type of ovarian tumor, which is composed predominantly of thyroid tissue and accounts for less than 1% of all ovarian neoplasms. It is classified as a specialized form of monodermal teratoma (a type of germ cell tumor). Despite being composed mainly of thyroid tissue, struma ovarii may produce and release thyroid hormones, leading to symptoms associated with hyperthyroidism in some cases.

Struma ovarii can be asymptomatic or present with various symptoms such as abdominal pain, distension, or menstrual irregularities. In rare instances, it might undergo malignant transformation into a thyroid-like carcinoma known as strumal carcinoid or thyroid carcinoma of the ovary. The definitive diagnosis is usually established through histopathological examination following surgical resection.

Ovarian neoplasms refer to abnormal growths or tumors in the ovary, which can be benign (non-cancerous) or malignant (cancerous). These growths can originate from various cell types within the ovary, including epithelial cells, germ cells, and stromal cells. Ovarian neoplasms are often classified based on their cell type of origin, histological features, and potential for invasive or metastatic behavior.

Epithelial ovarian neoplasms are the most common type and can be further categorized into several subtypes, such as serous, mucinous, endometrioid, clear cell, and Brenner tumors. Some of these epithelial tumors have a higher risk of becoming malignant and spreading to other parts of the body.

Germ cell ovarian neoplasms arise from the cells that give rise to eggs (oocytes) and can include teratomas, dysgerminomas, yolk sac tumors, and embryonal carcinomas. Stromal ovarian neoplasms develop from the connective tissue cells supporting the ovary and can include granulosa cell tumors, thecomas, and fibromas.

It is essential to diagnose and treat ovarian neoplasms promptly, as some malignant forms can be aggressive and potentially life-threatening if not managed appropriately. Regular gynecological exams, imaging studies, and tumor marker tests are often used for early detection and monitoring of ovarian neoplasms. Treatment options may include surgery, chemotherapy, or radiation therapy, depending on the type, stage, and patient's overall health condition.

The term "Brenner tumour" was first used by Robert Meyer, in 1932. Micrograph of a Walthard cell nest, the entity Brenner ... Brenner tumours are an uncommon subtype of the surface epithelial-stromal tumour group of ovarian neoplasms. The majority are ... Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (April 2005). "Malignant Brenner tumour--a case report". Indian ... Caccamo D, Socias M, Truchet C (May 1991). "Malignant Brenner tumor of the testis and epididymis". Archives of Pathology & ...
"Brenner tumor of ovary , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info.nih.gov. ... "Granulosa cell tumor of the ovary , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info. ... "Ovarian Germ Cell Tumors Treatment". National Cancer Institute. 1980-01-01. Retrieved 2017-12-01. Seiden, Michael (2015). " ... "Yolk sac tumor". www.pathologyoutlines.com. Retrieved 2019-12-11. Weerakkody, Yuranga. "Ovarian serous cystadenoma , Radiology ...
It is in the transitional cell category of ovarian tumours which also includes malignant Brenner tumour and benign Brenner ... Brenner tumour Tazi, EM.; Lalya, I.; Tazi, MF.; Ahellal, Y.; M'rabti, H.; Errihani, H. (2010). "Transitional cell carcinoma of ... tumour. Low mag. Very high mag. The main treatment is surgical resection. These tumours do better than other types of ...
Bradley, Rich (January 15, 1992). "Brenner, 44, Succumbs to Brain Tumor". Philadelphia Daily News. Abraham Lincoln High School ... Ziegler Elementary School Glenn Brenner, Washington, D.C., sportscaster Larry Cannon, former professional basketball player Gia ...
To be classified as a malignant Brenner tumor, it must have Brenner tumor foci and transitional cell carcinoma. The ... endometrioid tumor, clear-cell tumor, mucinous tumor, and undifferentiated or unclassified tumors. Annually worldwide, 230,000 ... Mixed tumors contain elements of more than one of the above classes of tumor histology. To be classed as a mixed tumor, the ... Germ cell tumors of the ovary develop from the ovarian germ cells. Germ cell tumor accounts for about 30% of ovarian tumors, ...
Shapiro, Leonard (15 January 1992). "Glenn Brenner Succumbs to Brain Tumor at 44; Sportscaster's Irreverent Humor Made Him a ... Brenner had once sought the intervention of church authorities to allow her to attend a Redskins game, but she wasn't permitted ... Suddenly, Brenner opened his eyes, made his trademark half-wink, half-grimace, and waved. Everyone in the room gasped. Peterson ... DC sportscaster Glenn Brenner (see above) was a Roman Catholic who graduated from Saint Joseph's University in Philadelphia, a ...
Shapiro, Leonard (January 15, 1992). "Glenn Brenner Succumbs to Brain Tumor at 44". Washington Post. Silman, Anna (March 10, ... former Saturday Night Live writer and comedian Glenn Brenner - Washington, D.C, sportscasting legend for WUSA-TV Richard ...
Shapiro, Leonard (January 15, 1992). "Glenn Brenner Succumbs to Brain Tumor at 44". Washington Post. Farhi, Paul, "After more ... Brenner often ribbed Peterson for his lifelong support of the also-ran Boston Red Sox major league baseball team. Brenner and ... Viewers also enjoyed Peterson's banter with sportscaster Glenn Brenner, who was the city's most popular broadcast journalist ...
After the game, the Redskins dedicated their win to WUSA sports anchor Glenn Brenner, who died from a brain tumor two days ... Shapiro, Leonard (January 15, 1992). "Glenn Brenner Succumbs to Brain Tumor at 44". Washington Post. Retrieved May 5, 2017. ...
Fritz Brenner (1877-1969), German pathologist (see Brenner tumor). Alexander Breslow (1928-1980), American pathologist (see ... discoverer of Rosai-Dorfman disease and the desmoplastic small round cell tumor. Gustave Roussy (1874-1948), Swiss-French ...
Ovarian tumors including Brenner tumors, adult granulosa cell tumors, and transitional cell tumors. Breast carcinomas Vaginal, ... and in non-epithelial tumors. Batistatou, Anna; Scopa, Chrisoula D. (2008). "Review Articles: Pathogenesis and Diagnostic ...
That same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by nests of ... They are pathognomonic for granulosa cell tumors. Histologically, these tumors consists of monotonous islands of granulosa ... "Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report". Acta Cytologica ...
Another ovarian tumor where Reinke crystalloids were noted is the Brenner tumour, an epithelial-stromal ovarian tumor ... Others were classified as stromal Leydig cell tumors as seen in tumors of the testes because Reinke crystalloids were ... "Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report". Acta Cytologica ... The stromal Leydig tumors occurred at an average age of 61 years and were associated with ovarian hyperandrogenism which led to ...
Wrong Diagnosis.com, Brenner tumors v t e (Histology, Gynaecology, All stub articles, Oncology stubs). ... It has been suggested that these cell rests are the histogenetic origins of Brenner tumors, due to the histological similarity ... High magnification micrograph of a Brenner tumor showing the characteristic coffee bean nuclei which are also seen in Walthard ... Also, it has been proposed that Brenner tumors and Walthard cell rests signify urothelial differentiation within the female ...
"Brenner tumour" in honor of his findings. Incredibly, it wasn't until the 1950s that Brenner became aware of the honor. January ... Reconstructive Surgery Fritz Brenner at Who Named It Brenner's tumour Who Named It (Articles with short description, Short ... Fritz Brenner (16 December 1877, in Osthofen - 26 December 1969, in Johannesburg) was a German physician and pathologist. He ... In 1907 he described a unique ovarian tumour in an article titled Das Oophoroma folliculare, published in the journal ...
"Brenner tumour". In 1932 pathologist Robert Meyer coined the term in honor of Fritz Brenner, who described the tumor in a 1907 ... Ernst Gottlob Orthmann at Who Named It Brenner's tumour at Who Named It January/February 2007 - Volume 13 - Issue 1 > Powell's ... In 1899 he published two papers on a certain type of ovarian tumor that would later become known as a " ... Pearls: Fritz Brenner, MD (1877-1969) Female Pelvic Medicine & Reconstructive Surgery (Articles with short description, Short ...
Examples include: Brenner tumor of the ovary Fibroadenoma of the breast Phyllodes tumor of the breast Tavassoli, F.A., Devilee ... A fibroepithelial neoplasm (or tumor) is a biphasic tumor. They consist of epithelial tissue, and stromal or mesenchymal tissue ... ISBN 92-832-2412-4 derm/346 at eMedicine - "Premalignant Fibroepithelial Tumor" v t e v t e v t e (Articles with short ... description, Short description is different from Wikidata, Glandular and epithelial neoplasia, Connective/soft tissue tumors ...
Brenner tumors may be benign or malignant, depending on whether the tumor cells invade the surrounding tissue. Small cell ... If the tumor has spread beyond the ovary at diagnosis, the prognosis is poor Brenner tumors are uncommon surface-epithelial ... the tumor cells resemble benign cells a well-differentiated tumor closely resembles benign tumors a poorly differentiated tumor ... The tumors may be very small to very large, and may be solid or cystic. Histologically, the tumor consists of nests of the ...
... in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 ( ... "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma ... "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma ...
... in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 ( ...
... in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 ( ... 2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin ... alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291-7. PMID 9515818. ...
... in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 ( ...
"Tumor Markers". Retrieved June 6, 2013. Haug, U; Rothenbacher, D; Wente, M N; Seiler, C M; Stegmaier, C; Brenner, H (2007). " ... Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. Although ... Diagnosis of specific tumor types, particularly in certain brain tumors and other instances where biopsy is not feasible. ... Staging: some tumor markers are included in the staging procedures for some tumor localizations. Prognosis to plan the ...
glycolysis tumor metabolome PKM2 Haug, U.; Rothenbacher, D.; Wente, M. N.; Seiler, C. M.; Stegmaier, C.; Brenner, H. (2007). " ... Tumor M2-PK can be elevated in many tumor types, rather than being an organ-specific tumor marker such as PSA. Increased stool ... September 2001). "Tumor M2 pyruvate kinase in plasma of patients with urological tumors". Tumour Biol. 22 (5): 282-5. doi: ... which correlated with the tumor stage. The combination of Tumor M2-PK with the appropriate classical tumor marker, such as CEA ...
"Glenn Brenner Succumbs to Brain Tumor at 44". Washington Post. Bradley, Rich (January 15, 1992). "Brenner, 44, Succumbs to ... He mentioned Brenner's on-air stunt, and told Snyder that Brenner would be let go in a short time. Intrigued with Brenner's on- ... At 9:30 a.m. on January 11, surgeons operated on Brenner for four hours and discovered an inoperable malignant brain tumor. ... Glenn Brenner was born on January 2, 1948, in Philadelphia, Pennsylvania, to Bill and Edie Brenner. At the age of four, he ...
... brenner tumor MeSH C13.371.056.630.705.331 - carcinoma, endometrioid MeSH C13.371.056.630.705.398 - granulosa cell tumor MeSH ... brenner tumor MeSH C13.371.820.800.418.685.331 - carcinoma, endometrioid MeSH C13.371.820.800.418.685.398 - granulosa cell ... wilms tumor MeSH C13.371.820.800.820.535.585.220 - denys-drash syndrome MeSH C13.371.820.800.820.535.585.950 - wagr syndrome ... sertoli-leydig cell tumor MeSH C13.371.820.800.418.685.765 - thecoma MeSH C13.371.820.800.418.875 - uterine neoplasms MeSH ...
... brenner tumor MeSH C19.391.630.705.331 - carcinoma, endometrioid MeSH C19.391.630.705.398 - granulosa cell tumor MeSH C19.391. ... sertoli-leydig cell tumor MeSH C19.344.410.765 - thecoma MeSH C19.344.421.249 - adenoma, islet cell MeSH C19.344.421.249.500 - ... sertoli-leydig cell tumor MeSH C19.344.894.800 - thyroid nodule MeSH C19.391.482.293 - eunuchism MeSH C19.391.482.600 - ... granulosa cell tumor MeSH C19.344.410.464 - luteoma MeSH C19.344.410.531 - meigs syndrome MeSH C19.344.410.648 - ...
Brenner tumor, granulosa cell tumor, stromal tumor, dysgerminoma, fibroma, or metastatic tumor to the ovary. Meigs syndrome is ... Brenner tumour, and occasionally granulosa cell tumour). Meigs syndrome resolves after the resection of the tumor. Because the ... Meigs syndrome may mimic other conditions, since it is tumor arising from ovaries, pathology of any organs present in the ... These include various gynecological disorders of the uterus such as endometrial tumor, sarcoma, leiomyoma (pseudo-Meigs ...
... benign ovarian Brenner tumors, benign Walthard cell rests, and paragangliomas. GATA3 has been shown to interact with the ... Similar to breast tumors, the role of GATA3 in the genesis of other tumor types is unclear but detection of its transcription ... Liu H, Shi J, Wilkerson ML, Lin F (July 2012). "Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues ... Ordóñez NG (September 2013). "Value of GATA3 immunostaining in tumor diagnosis: a review". Advances in Anatomic Pathology. 20 ( ...
Thore Edvard Brandt Brenner tumour - Fritz Brenner Brewer kidney - George Emerson Brewer Bright disease - Richard Bright Brill- ... Joseph Thiers Ackerman tumor - Lauren Ackerman Adams-Oliver syndrome - Robert Adams, William Oliver Adams-Stokes syndrome (a.k. ... Williams Wilms tumor - Max Wilms Wilson's disease - Samuel Alexander Kinnier Wilson Willis-Ekbom syndrome - Thomas Willis, Karl ... Lisa Welander Kuttner's tumor - Hermann Küttner Lafora's disease - Gonzalo Rodriguez Lafora Laron syndrome - Zvi Laron Laurence ...
The term "Brenner tumour" was first used by Robert Meyer, in 1932. Micrograph of a Walthard cell nest, the entity Brenner ... Brenner tumours are an uncommon subtype of the surface epithelial-stromal tumour group of ovarian neoplasms. The majority are ... Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (April 2005). "Malignant Brenner tumour--a case report". Indian ... Caccamo D, Socias M, Truchet C (May 1991). "Malignant Brenner tumor of the testis and epididymis". Archives of Pathology & ...
... of benign ovarian epithelial tumors. The World Health Organization classification groups them into benign, borderline, and ... malignant on the basis of proliferation and invasiveness, and borderline Brenner tumor is defined a … ... Brenner tumors arise from ovarian epithelium, accounting for approximately 5% ... and borderline Brenner tumor is defined as "displaying epithelial proliferation beyond that seen in benign Brenners tumor, but ...
It includes benign Brenner tumor, borderline Brenner tumor, and malignant Brenner tumor. ... A tumor composed of solid and cystic nests of neoplastic urothelial-type cells in an abundant stromal component that is dense ... It includes benign Brenner tumor, borderline Brenner tumor, and malignant Brenner tumor. [from NCI] ... Brenner tumor of the ovary - ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. ...
A tumor tissue microarray containing 428 ovarian cancers was analyzed -- learn why gene amplification occurs rarely. ... Malignant Brenner tumor. 5. 4. 50.0. 0.0. 50.0. 0.0. n.a.. 3. 0.0. n.a.. ... Malignant Brenner tumor. 5. 4. 50.0. 0.0. 50.0. 0.0. n.a.. 3. 0.0. n.a.. ... All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen ...
The aim of this study was to investigate cytological features of Brenner tumors according to tumor grade using imprint cytology ... Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute ... testis Sertoli cell tumor imprint cytology coffee bean nuclei Acta Cytologica Sertoli Cell Tumor of the Testis Report... ... Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute in another window ...
Ovarian fibromas constitute the majority of the benign tumors seen in Meigs syndrome. ... Meigs syndrome is defined as the triad of benign ovarian tumor with ascites and pleural effusion that resolves after resection ... Aoshima M, Tanaka H, Takahashi M, Nakamura K, Makino I. Meigs syndrome due to Brenner tumor mimicking lupus peritonitis in a ... Germ cell tumors. These tumors originate from the germ cell and constitute 10-15% of all ovarian tumors. All are malignant ...
9. Brenner tumor of the ovary. A clinicopathologic study of 60 tumors in 54 women.. Silverberg SG. Cancer; 1971 Sep; 28(3):588- ... Brenner tumor of the ovary--a clinicopathological report of 5 cases].. Li AY; Li XL; Xing LY. Zhonghua Zhong Liu Za Zhi; 1987 ... 3. Coexistence of brenner tumor and struma ovarii: case report.. Takeuchi K; Ohbayashi C; Kitazawa S; Ohara N; Maruo T. Eur J ... Malignant Brenner tumour--a case report.. Marwah N; Mathur SK; Marwah S; Singh S; Karwasra RK; Arora B. Indian J Pathol ...
SELECTIVE EXPRESSION OF CYTOKERATIN POLYPEPTIDES IN VARIOUS EPITHELIA OF HUMAN BRENNER TUMOR. Human Pathology. 19 (6):640-650. ... Barnea M., Stein M., Winograd-Katz S., Shalev M., Arman E., Brenner O., Thalji F., Kanaan M., Elinav H., Stepensky P., Geiger B ... Adutler-Lieber S, Friedman N, Geiger B (2018). Expansion and anti-tumor cytotoxicity of T-cells are augmented by substrate- ... Stein M., Barnea-Zohar M., Shalev M., Arman E., Brenner O., Winogrsd-Katz S., Gerstung J., Thalji F., Kanaan M., Elinav H., ...
Wilms tumor (WT) is a type of kidney cancer that occurs in children. ... Brenner and Rectors The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 41. ... The tumor may become quite large, but usually remains self-enclosed. Spread of the tumor to the lungs, lymph nodes, liver, bone ... Wilms tumor and other childhood kidney tumors treatment (PDQ) - health professional version. www.cancer.gov/types/kidney/hp/ ...
Stromal Overgrowth in a Brenner Tumor or Ovarian Fibroma With Minor Sex Cord Elements? July 01, 2015 ...
Wilms tumor (WT) is a type of kidney cancer that occurs in children. ... Brenner and Rectors The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 41. ... The tumor may become quite large, but usually remains self-enclosed. Spread of the tumor to the lungs, lymph nodes, liver, bone ... Wilms tumor and other childhood kidney tumors treatment (PDQ) - health professional version. www.cancer.gov/types/kidney/hp/ ...
... and Brenner tumors.. Borderline Epithelial Tumors. When looked at in the lab, some ovarian epithelial tumors dont clearly ... stromal tumors include granulosa cell tumors (the most common type), granulosa-theca tumors, and Sertoli-Leydig cell tumors, ... Ovarian stromal tumors. About 1% of ovarian cancers are ovarian stromal cell tumors. More than half of stromal tumors are found ... Epithelial ovarian tumors. Epithelial ovarian tumors start in the outer surface of the ovaries. These tumors can be benign (not ...
These "benign" epithelial tumors include serous adenomas, mucinous adenomas and Brenner tumors. ... Germ Cell Tumors. These tumors are most common in women in their 20s. But women of any age can get them. Most tumors that start ... Epithelial Tumors. Most cases of ovarian cancer involve tumors that start in the layer of tissue that covers your ovaries. Its ... These types of tumors are often diagnosed earlier than others.. The most common subtypes are granulosa-theca tumors and Sertoli ...
Malignant Brenner tumor associated with a germline BRCA2 mutation. Toboni MD, Smith HJ, Dilley SE, Novak L, Leath CA. Toboni MD ...
My diagnosis is a bit unclear ... one group says it was a Brenner Tumor and another say it is edometrioid cancer....both kinds ... back to work next week but finding it tough without seeing doctors all the time to assure me that there isnt another tumor ...
Malignant Brenner Tumor,o,1462,TUMOR;NEOPLASIA;GROWTH;NEOPLASM;TUMORS,1,0,1,,, 301,2717,Pulmonary Edema,l,4865,PULMONARY;LUNG; ... Brenner Tumor,y,1897,TUMOR;NEOPLASIA;GROWTH;NEOPLASM;TUMORS,1,0,1,,, 1002,10395,Myelolipoma,y,1952,,1,0,1,,, 1003,3337,Bladder ... Giant Cell Tumor of Bone,o,2022,TUMOR;NEOPLASIA;GROWTH;NEOPLASM;TUMORS;BONE;OSTEO;ORTHOPEDIC;BONES,1,0,1,,, 380,6693,Hepatitis ... Bone Tumor Benign,r,1861,BONE;OSTEO;ORTHOPEDIC;BONES;TUMOR;NEOPLASIA;GROWTH;NEOPLASM;TUMORS,0,0,0,,, 3298,14673,Hepatitis C,i, ...
Benign tumors, including mucinous cystadenomas, benign teratomas, and Brenner tumors, have also been reported. ... Bilateral breast tumors, malignant phyllodes tumor and invasive lobular carcinoma in a 46,XX/46,XY mosaic female with family ... Gonadal tumors with malignant potential occur in 2.6% of all cases of ovotesticular disorder of sexual development. The testis ... One case report of a 47-year-old 46,XX/46,XY woman with a malignant phyllodes tumor in the right breast and an invasive lobular ...
9000/1 , morphology ,, Brenner tumor, borderline malignancy , primary_diagnosis ,, Brenner tumor, proliferating , primary_ ... site A C177537 GDC Value Terminology C179451 Primary Tumor Site The anatomic location of a primary tumor. Primary tumor site , ... Upon adinistration, the L19 moiety of onfekafusp alfa binds to the ED-B domain of fibronectin on tumor cells in the tumor ... diagnosis C C177537 GDC Value Terminology C9459 Borderline Ovarian Brenner Tumor A transitional cell neoplasm of low malignant ...
Benign Brenner Tumor Brenner Tumor of Ovary Malignant Brenner Tumor Ovarian Brenner Tumor Proliferative Brenner Tumor Date ... Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.. Terms. Brenner Tumor ... Brenner Tumor of Ovary Narrower Concept UI. M000738550. Terms. Brenner Tumor of Ovary Preferred Term Term UI T769329. Date04/14 ... Benign Brenner Tumor Narrower Concept UI. M0472443. Terms. Benign Brenner Tumor Preferred Term Term UI T609171. Date09/13/2004 ...
Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine ... Brenner H, Loomis D. 1994. Varied forms of bias due to nondifferential error in measuring exposure. Epidemiology 5(5):510-517, ... Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study. * ...
Brenner proliferative tumor]. / La tumeur proliférative de Brenner Pusel, J; Schumacher, J C; Renaud, R; Philippe, E; Gandar, R ...
Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology ... Koyama Y, Brenner DA. 2017. Liver inflammation and fibrosis. J Clin Invest 127(1):55-64. doi:10.1172/JCI88881 PMID:28045404 ... Brenner DA, Paik Y, Schnabl B. 2015. Role of gut microbiota in liver disease. J Clin Gastroenterol 49Suppl1:S25-S27. doi: ... Seki E, Brenner DA, Karin M. 2012. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and ...
Brenner tumor Current Synonym true false 200484019 Brenner tumour Current Synonym true false ... Brenner tumor (morphologic abnormality). Code System Preferred Concept Name. Brenner tumor (morphologic abnormality). ...
Benign Brenner Tumor Brenner Tumor of Ovary Malignant Brenner Tumor Ovarian Brenner Tumor Proliferative Brenner Tumor Date ... Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.. Terms. Brenner Tumor ... Brenner Tumor of Ovary Narrower Concept UI. M000738550. Terms. Brenner Tumor of Ovary Preferred Term Term UI T769329. Date04/14 ... Benign Brenner Tumor Narrower Concept UI. M0472443. Terms. Benign Brenner Tumor Preferred Term Term UI T609171. Date09/13/2004 ...
Solis-Herruzo JA, Brenner DA, Chojkier M: Tumor necrosis factor alpha inhibits collagen gene transcription and collagen ... which interacts with the tumor-suppressor protein DAN that contains growth or tumor suppressive activity in vitro [63]. PHB ... Iwata S, Sato Y, Asada M, Takagi M, Tsujimoto A, Inaba T, Yamada T, Sakamoto S, Yata J, Shimogori T, et al: Anti-tumor activity ... Lee SW, Reimer CL, Campbell DB, Cheresh P, Duda RB, Kocher O: H-cadherin expression inhibits in vitro invasiveness and tumor ...
A Rare Case of Ruptured Malignant Ovarian Brenner Tumor Andi Kurniadi, Muhammad Khalif Anfasa, [...] Hasrayati Agustina , ... A Rare Case of Ruptured Malignant Ovarian Brenner Tumor Andi Kurniadi, Muhammad Khalif Anfasa, Hasrayati Agustina , Birgitta ...
Brenner GJ, *Woolf CJ. (2002) ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 ... 1997) Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons. J Neurosci 17:975-982. ... 1997) Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience 81:255-262. ... 2005) Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter ...
  • Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour. (wikipedia.org)
  • Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. (wikipedia.org)
  • subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
  • This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2020, Case 31, and is benign Brenner tumor in the ovary. (cap.org)
  • Most tumors are confined to the ovary at diagnosis, and malignant Brenner tumors have a better prognosis than other epithelial ovarian carcinomas. (cap.org)
  • Carcinoid , or well-differentiated neuroendocrine tumor, of the ovary is uncommon but may occur as a monodermal teratoma or a somatic-type malignancy arising from a teratoma or dermoid cyst. (cap.org)
  • A Rare Case of Grade 1 Endometrioid Adenocarcinoma of the Uterus With Omental Metastasis with Brenner Tumor of the Ovary in a Postmenopausal Female. (bvsalud.org)
  • Reported rates of mucinous carcinoma diagnoses have declined dramatically, but expert pathology reviews suggest that this reflects increased recognition of metastases from occult gastrointestinal primary tumors to the ovary, rather than a true decline in rates of ovarian primary tumors. (uofmhealth.org)
  • Borderline ovarian tumors (BOTs) are abnormal cells or growths that develop in the tissue encapsulating an ovary. (medicalnewstoday.com)
  • Squamous cell carcinoma of the ovary is rare and usually arise from preexisting cystic teratomas, endometriosis or Brenner tumors which undergo carcinomatous degeneration in their epithelial elements. (koreamed.org)
  • However, when a malignant tumor with transitional morphology is encountered, the approach to diagnosis must essentially address two aspects: first, to establish whether a tumor in question is originating from a preexisting BT or a de novo transitional cell carcinoma (TCC) of the ovary and second in cases with widespread involvement of the pelvic organs, origin from the urinary bladder must be ruled out. (ijhi.org)
  • A Brenner component was lacking, a feature of the diagnosis of transitional cell carcinoma of the ovary. (surgpath4u.com)
  • The category of 'transitional cell carcinoma of the ovary' represents primary ovarian carcinomas in which definite urothelial features are identified, but no benign or borderline proliferating Brenner tumor are found. (surgpath4u.com)
  • The natural progression of these tumors also lend support to this theory, as Brenner tumors (even borderline and malignant) have a much better prognosis than transitional cell carcinomas of the ovary. (surgpath4u.com)
  • Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. (surgpath4u.com)
  • Reidel I, Czernobilsky B, Lifschitz-Mercer B. Brenner tumors but not transitional cell carcinomas of the ovary show urotehlial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. (surgpath4u.com)
  • Meigs syndrome is associated with a benign tumor in the ovary. (syndromespedia.com)
  • In Meigs syndrome, the type of ovarian syndrome is fibroma, whereas in pseudo-Meigs syndrome cystadenoma, thecoma or a granulosa tumor types are prominent in ovary 5 . (syndromespedia.com)
  • Histologically, most of them are serous or mucinous, but endometrioid, clear cell, Brenner (transitional cell) or mixed histotypes can be also seen. (intechopen.com)
  • This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. (medscape.com)
  • Admixtures of other surface epithelial tumors (serous, endometrioid) are common, thus, the transitional cell component must comprise over 50% of the tumor to be diagnosed as transitional cell carcinoma. (surgpath4u.com)
  • These IHC stuides have lead most authors to conclude that TCCs are a poorly-differentiated adenocarcinoma akin to other surface epithelial ovarian tumors such as serous and endometrioid types. (surgpath4u.com)
  • Similar to other epithelial ovarian tumors, Benner tumors are classified as benign, borderline/atypical proliferative, or malignant. (cap.org)
  • Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)
  • Solid epithelial ovarian tumors are almost invariably malignant. (medscape.com)
  • Small cysts are often present, but benign Brenner tumors are rarely predominantly cystic. (cap.org)
  • Microscopically, the tumors are composed of solid to cystic nests of epithelial cells embedded in a fibrous stroma. (cap.org)
  • These tumors are predominantly cystic but may contain variable solid areas, often representing a coexisting benign Brenner component. (cap.org)
  • Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
  • Papillary proliferations of transitional-cell type epithelium projecting into cystic lumens are typical of borderline Brenner tumor. (surgpath4u.com)
  • Grossly, borderline Brenner tumors are cystic and unilocular or multilocular. (surgpath4u.com)
  • This gross image demonstrates a partly solid and cystic tumor. (surgpath4u.com)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
  • 10 ] Further, among carriers of deleterious mutations in BRCA1 or BRCA2, increasing evidence suggests that many tumors previously classified as ovarian high-grade serous carcinoma may develop from malignant cells arising in the tubal epithelium (serous tubal intraepithelial carcinoma [STIC]), although these tumors continue to be referred to as ovarian cancers in most writings. (uofmhealth.org)
  • In this article the authors reviewed literature regarding mucinous ovarian carcinoma (MOC), which represents a special challenge as a rare ovarian tumour (about 3%) with unique clinical characteristics as compared to serous ovarian carcinoma (SOC). (bjmo.be)
  • The immunohistochemical profile of the tumor including the solid islands was consistent with a TCC (strong ER+, WT1+, strong p16+, p53+, CK7−, and CK20−) [Figure 1] F-H. In diagnostic accordance with WHO 2014, the tumor was called a high-grade serous carcinoma with transitional cell morphology. (ijhi.org)
  • Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
  • Malignant Brenner tumors are uncommon ovarian carcinomas and represent less than 5% of all Brenner tumors. (cap.org)
  • Ovarian cancer is a rare disease, with carcinomas comprising approximately 90% of tumors and germ cell and stromal tumors accounting for the remainder. (uofmhealth.org)
  • The category of ovarian borderline tumor or tumor of low-malignant potential, which historically had been considered in the context of ovarian cancer, is now generally considered a nonmalignant entity, although it has a postulated relationship with the development of some histological subtypes of low-grade ovarian carcinomas. (uofmhealth.org)
  • However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
  • In contrast, 80%-90% of ovarian carcinomas are detected after the age of 40, and 40% of these tumors are detected after the age of 65. (biomedcentral.com)
  • Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
  • Some Brenner tumors may arise from the wall of a mucinous cystadenoma. (surgpath4u.com)
  • Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
  • Borderline/atypical proliferative Brenner tumors are often larger than benign Brenner tumors, with an average diameter of 18 cm. (cap.org)
  • Histologically, malignant Brenner tumors are associated with a benign or borderline/atypical proliferative Brenner tumor component. (cap.org)
  • Medical professionals may also refer to BOTs as atypical proliferative tumors or tumors of low malignant potential. (medicalnewstoday.com)
  • Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
  • According to GlobalData, Phase I drugs for Atypical Teratoid Rhabdoid Tumor does not have sufficient historical data to build an indication benchmark PTSR for Phase I. (pharmaceutical-technology.com)
  • In his textbook, Fletcher prefers to employ the term borderline Brenner tumors to encompass both entities and add the qualifier 'low-grade' for proliferative-type tumors and 'high-grade' for tumors with more atypical features. (surgpath4u.com)
  • Only a small number of malignant proliferating trichilemmal tumor (MPTT) cases with documented invasion and metastasis have been reported. (logicalimages.com)
  • By contrast, increased CCL5 expression resulting from RUNX3 mutation is associated with more tumor metastasis in the lung. (nature.com)
  • Furthermore, a recent clinical trial for a CCR5 inhibitor treatment to patients suffering from liver metastasis of colorectal cancer showed its effect on reducing tumor mass with better prognosis, suggesting CCL5-CCR5 axis might also provide a procancer activity 22 . (nature.com)
  • In turn, de novo formed vessels enhance tumor invasion and metastasis through the production of MMP 2 and 9 and uPA, which further degrade ECM. (biomedcentral.com)
  • The current tumor-node-metastasis (TNM) framework relies exclusively on locoregional tumor expansion(s) of the primary tumor but neglects substantial tumor- and host-related biological differences [ 17 ]. (biomedcentral.com)
  • Secondary metastasis or contiguous spread to the heart constitutes the most common malignant tumors. (sts.org)
  • Some authors propose that these tumors be subclassified into 'proliferative' or 'low malignant potential' based on the amount of cytologic atypia. (surgpath4u.com)
  • Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
  • Various studies have shown an association of Brenner tumor with endometrial hyperplasia , polyp , or early-stage carcinoma , probably due to its estrogen -secreting nature . (bvsalud.org)
  • Transitional cell carcinoma represent a more aggressive neoplasm compared to malignant Brenner tumors. (surgpath4u.com)
  • Occult tumor cells that can lead to loco-regional recurrence and distant metastases are the main reason for the poor prognosis of patients suffering from squamous cell carcinoma of the head and neck [ 1 ]. (biomedcentral.com)
  • con presentación clínica inicial en etapas localmente avanzadas, con diagnóstico de carcinoma de mama invasivo de tipo no especial, pobremente diferenciado y receptores para estrógeno y progesterona positivos. (bvsalud.org)
  • An ovarian Leydig cell tumor stained intensely, whereas granulosa cell tumors were negative. (elsevierpure.com)
  • Testicular Leydig cells stained moderately to intensely, as did a testicular Leydig cell tumor. (elsevierpure.com)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Borderline and malignant Brenner tumors occur in women who are approximately 10 years older. (surgpath4u.com)
  • Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)
  • Malignant tumors of the heart constitute approximately 10% of all pediatric tumors. (sts.org)
  • In the case of a malignant tumor, it may spread to surroundings area including colon and lung 4 . (syndromespedia.com)
  • The most common benign tumors of the heart are rhabdomyoma, fibroma, teratoma and myxoma. (sts.org)
  • The coffee bean nuclei are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumour, the ovarian granulosa cell tumour, with the fluid-filled spaces Call-Exner bodies between the granulosa cells. (wikipedia.org)
  • Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
  • Inhibition of MMPs has provided a significant increase in the survival rate in clinical trials, according to the frequent overexpression of MMPs in malignant tumors and the correlation with a highly aggressive phenotype and poor prognosis [ 8 - 10 ]. (biomedcentral.com)
  • In contrast, the above case of higher grade borderline tumor exhibits more prominent nuclear atypia as well as high mitotic activity and areas of necrosis. (surgpath4u.com)
  • More pronounced nuclear atypia distinguishes low-grade from high-grade borderline tumors. (surgpath4u.com)
  • Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • Dr. Andrew Brenner, neuro-oncologist, at The University of Texas Health Science Center at San Antonio's Cancer Therapy & Research Center, discusses a new way to fight brain tumors. (blogspot.com)
  • Can you discuss brain tumors and ultimately how they grow and evolve? (blogspot.com)
  • Dr. Andrew Brenner: Ultimately, brain tumors aren't the most common type of tumor. (blogspot.com)
  • One of the things that we do know about the cause of brain tumors is what we refer to as 'ionizing radiation,' which is different from other types of radiation from what we call the electromagnetic spectrum. (blogspot.com)
  • Ionizing radiation is well known in terms of causing brain tumors. (blogspot.com)
  • We see probably a total of 20,000 malignant primary brain tumors in the United States annually. (blogspot.com)
  • Overall, I would say approximately 50,000 brain tumors are diagnosed annually in the United States alone. (blogspot.com)
  • Frankly Speaking About Brain Tumors An excellent brain tumor guide from the National Brain Tumor Foundation and Cancer Support Community. (virtualtrials.org)
  • "Sometimes Your Head" A FREE illustrated book for children dealing with brain tumors. (virtualtrials.org)
  • Brain Tumors: Finding the Ark. (virtualtrials.org)
  • The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. (nih.gov)
  • Here, we sought to exploit the merits of a well-characterized GEM model of pancreatic cancer to determine whether proteomics technologies allow identification of protein changes associated with tumor development and whether such changes are relevant to human pancreatic cancer. (nih.gov)
  • A doctor will need to properly diagnose a BOT since treatment for his type of tumor differs from treatment for ovarian tumors that are definitively malignant. (medicalnewstoday.com)
  • Nests are large and crowded and may show fusion, as a result of epithelial proliferation that exceeds what is seen in benign Brenner tumor. (cap.org)
  • Proliferating Brenner is basically a proliferation of bland transitional-type cells with no cytologic atypia while Brenner tumor of low malignant potential exhibit mild to moderate cytologic atypia. (surgpath4u.com)
  • Likewise, the immunohistochemistry results showed significant decreases in tumor proliferation and vascularization in the treatment-group in comparison to the control-group of 26%(p≤0.05) and 32.2%(p≤0.05) respectively. (biomedcentral.com)
  • They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)
  • Dr. Brenner focuses not only on clinical management, but also on the development of novel therapies to treat these cancers. (tpr.org)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • Up to 1/3 of Brenner tumors contain mucinous elements (mucinous glands, cysts or co-existing mucinous adenocarcinomas). (surgpath4u.com)
  • It's pipeline products include Voyager-V1 for solid tumors, MV-NIS for bladder cancer, Voyager-V1 + pembrolizumab for non-small cell lung cancer, head and neck cancer, Voyager-V1 + cemiplimab for multiple cancer indications among others. (pharmaceutical-technology.com)
  • These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
  • According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
  • Benign Brenner tumors account for approximately 5% of all benign ovarian epithelial tumors and are typically found incidentally in women in the 5th to 7th decades of life. (cap.org)
  • Another study from 2021 notes that BOTs account for 10-15% of ovarian epithelial tumors. (medicalnewstoday.com)
  • Brenner tumours are an uncommon subtype of the surface epithelial-stromal tumour group of ovarian neoplasms. (wikipedia.org)
  • 2) This less common pattern is called 'Brenner-type', consisting of nests and cords of malignant transitional cells invading the fibrous ovarian stroma. (surgpath4u.com)
  • TCCs and Brenner tumors share transitional cell type morphology only, but TCCs do not exhibit true urothelial differentiation. (surgpath4u.com)
  • Brenner tumours very rarely can occur in other locations, including the testes. (wikipedia.org)
  • High blood pressure and kidney damage may occur as the result of the tumor or its treatment. (medlineplus.gov)
  • Approximately two-thirds of ovarian tumors occur in women during reproductive age, whereas less than 5% occur in children. (biomedcentral.com)
  • 60% of these tumors occur in females under the age of 40. (biomedcentral.com)
  • Malignant tumors of the heart mostly occur due to metastatic or contiguous spread and are more common than primary malignant tumors. (sts.org)
  • The benign Brenner tumor (BT) is easily diagnosed owing to its classic morphology. (ijhi.org)
  • Extensive sampling of both the ovarian masses revealed tumors with similar morphology. (ijhi.org)
  • The tumors are generally multilocular, and the mucus-containing loculi appear blue through the tense capsules. (medscape.com)
  • Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)
  • The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
  • Mean age at diagnosis is in the early 6th decade, and most tumors are unilateral. (cap.org)
  • According to the National Cancer Institute (NCI), around 75% of borderline ovarian tumors are stage 1 at the point of diagnosis, meaning tumors are confined to the ovaries or fallopian tubes. (medicalnewstoday.com)
  • The diagnosis of a Brenner type histology, a rare and generally benign ovarian affection, was obtained after complete surgical removal of the ovarian tumour. (bjmo.be)
  • There was extensive necrosis of the tumor with few viable areas. (ijhi.org)
  • Brenner tumor is a rare ovarian tumor which is usually benign, but rarely, it may be malignant. (bvsalud.org)
  • Malignant proliferating trichilemmal tumor (MPTT) - Clinical features concerning for potential malignant transformation include a location off the scalp, recent and/or rapid growth, ulceration of the surface, and size greater than 5 cm. (logicalimages.com)
  • Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. (wikipedia.org)
  • Tumors can arise from the endocardium, myocardium, blood vessels and pericardium. (sts.org)
  • These are benign tumors that arise from the cardiac myocyte and constitute the most common pediatric cardiac tumors. (sts.org)
  • Nadas and Ellison reported the prevalence of pediatric cardiac tumors (primary and metastatic) to be 0.027% in 11,000 pediatric autopsies. (sts.org)
  • Grossly, benign Brenner tumors are small (typically less than 2 cm) and unilateral. (cap.org)
  • Histologically, these tumors resemble non-invasive, low-grade urothelial neoplasms. (cap.org)
  • mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
  • 1. "Walthard rests and Brenner tumor immunohistological study", Katarzyna Boguszewska, Magdalena Trwoga, Juvenes Pro Medicina, 19-20 maja 2017 r. (edu.pl)
  • 2. "Walthard rests and Brenner tumor immunohistological study", Katarzyna Boguszewska, Magdalena Trwoga,The 25th International Medical Students' Conference, 27-29 kwietnia 2017 r. (edu.pl)
  • Borderline Brenner tumor is usually unilateral and range from 8 to 30 cm in diameter (larger than the benign counterpart). (surgpath4u.com)
  • The urinary bladder was free from any tumor involvement. (ijhi.org)
  • Furthermore, Brenner tumors express markers seen in normal and neoplastic bladder urothelium such as CK 13, CK20 and uroplakin III. (surgpath4u.com)
  • Bladder tumors in two young males occupationally exposed to MBOCA. (cdc.gov)
  • A benign tumor means the tumor can grow but will not spread. (cancer.net)