Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Mastectomy, Segmental: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Breast Neoplasms: Tumors or cancer of the human BREAST.Radiotherapy, Conformal: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Radiotherapy, High-Energy: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Radiotherapy, Image-Guided: The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Breast Diseases: Pathological processes of the BREAST.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Lung Neoplasms: Tumors or cancer of the LUNG.Radiation Tolerance: The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Organs at Risk: Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.Rectal Neoplasms: Tumors or cancer of the RECTUM.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Radiation-Sensitizing Agents: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.Mastectomy: Surgical procedure to remove one or both breasts.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Particle Accelerators: Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Cranial Irradiation: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Breast Feeding: The nursing of an infant at the breast.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Cell Line, Tumor: A cell line derived from cultured tumor cells.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Pelvic Neoplasms: Tumors or cancer of the pelvic region.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Adjuvants, Pharmaceutic: Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.Organ Sparing Treatments: Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.Heavy Ion Radiotherapy: The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Breast Neoplasms, Male: Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Xerostomia: Decreased salivary flow.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Radioisotope Teletherapy: A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Spinal NeoplasmsRisk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Lymphatic Irradiation: External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Mammography: Radiographic examination of the breast.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Cobalt Radioisotopes: Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Iridium Radioisotopes: Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Thoracic NeoplasmsClinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Fibrocystic Breast Disease: A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.Patient Positioning: Moving a patient into a specific position or POSTURE to facilitate examination, surgery, or for therapeutic purposes.Osteoradionecrosis: Necrosis of bone following radiation injury.Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Lymph Node Excision: Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Fiducial Markers: Materials used as reference points for imaging studies.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Laryngectomy: Total or partial excision of the larynx.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Radiotherapy Setup Errors: Mistakes committed in the preparations for radiotherapy, including errors in positioning of patients, alignment radiation beams, or calculation of radiation doses.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Supratentorial Neoplasms: Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.Postoperative Care: The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)Axilla: Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Nimustine: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Breast Self-Examination: The inspection of one's breasts, usually for signs of disease, especially neoplastic disease.Heavy Ions: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Preoperative Care: Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)Proton Therapy: The use of an external beam of PROTONS as radiotherapy.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Recurrence: The return of a sign, symptom, or disease after a remission.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).DeoxycytidineTreatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Chemoradiotherapy, Adjuvant: Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Radiation, Ionizing: ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.Vindesine: Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).Cancer Care Facilities: Institutions specializing in the care of cancer patients.SEER Program: A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)Nose Neoplasms: Tumors or cancer of the NOSE.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Prostatectomy: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).Esthesioneuroblastoma, Olfactory: A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Mammaplasty: Surgical reconstruction of the breast including both augmentation and reduction.Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Mice, Inbred BALB CTesticular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Postmenopause: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.
Tattoo medical issues
... controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on cancer-related ... resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the ... "Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A ...
Barth RJ Jr; Wells WA; Mitchell SE; Cole BF (2009). "A prospective, multi-institutional study of adjuvant radiotherapy after ... Breast Cancer Study Group of the Institut Curie (2011). "Management of Phyllodes Breast Tumors". The Breast Journal. 17 (2): ... fast-growing masses that form from the periductal stromal cells of the breast. They account for less than 1% of all breast ... Tan PH, Thike AA, Tan WJ, Thu MM, Busmanis I, Li H, Chay WY, Tan MH (2012). "Predicting clinical behaviour of breast phyllodes ...
It is the most commonly reported complication in breast radiation therapy patients who receive adjuvant axillary radiotherapy ... particularly for breast cancer. The difference between breast cancer recurrence in patients who receive radiotherapy vs. those ... Preventive (adjuvant) doses are typically around 45-60 Gy in 1.8-2 Gy fractions (for breast, head, and neck cancers.) Many ... This is most commonly seen in the treatment of breast cancer with wide local excision or mastectomy followed by adjuvant ...
In some cases a seroma may need to be drained prior to a course of radiotherapy adjuvant to surgery. The main ... "Consistency in seroma contouring for partial breast radiotherapy: Impact of guidelines", Int J Radiat Oncol Biol Phys, 66 (2): ... They are a treatment target in partial-breast radiation therapy, The larger the surgical intervention, the more likely it is ... ISBN 978-0-397-51624-7. M. A. Hayat (5 November 2008). Methods of Cancer Diagnosis, Therapy and Prognosis: Breast Carcinoma. ...
Intraoperative electron radiation therapy
1] "Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled ... largely due to mammograms and the use of adjuvant treatments such as radiotherapy. Local recurrence rates are greatly reduced ... Full-Dose Intraoperative Radiotherapy With Electrons During Breast-Conserving Surgery Ann. Surg.,242(1): 101-106.2005. G Loi et ... Intraoperative radiotherapy for breast cancer, Lancet Oncol ,5 (3): 165-73, 2004 Timothy M. Pawlik et al Potential ...
1997). "Effect of Krestin as adjuvant treatment following radical radiotherapy in non-small cell lung cancer patients". Cancer ... 1995). "Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer". ... The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa)". Diseases of the ... February 1992). "Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer ...
These women will have either a part of their breast or the whole breast removed, and they will often receive radiotherapy and ... Baum's team was the first to demonstrate the effectiveness of adjuvant tamoxifen for early breast cancer, which has contributed ... adjuvant treatment for breast cancer". Lancet. 365 (9453): 60-2. doi:10.1016/S0140-6736(04)17666-6. PMID 15639680. Baum M, ... "What are the drawbacks of breast screening?" published in 2011, Michael Baum criticised the NHS Breast Screening Programme: ...
For example, radiotherapy or systemic therapy is commonly given as adjuvant treatment after surgery for breast cancer. Systemic ... Adjuvant therapy in breast cancer is used in stage one and two breast cancer following lumpectomy, and in stage three breast ... adjuvant either radiotherapy or chemotherapy may be used following orchidectomy. Previously, mainly radiotherapy was used, as a ... Adjuvant systemic therapy and radiotherapy are often given following surgery for many types of cancer, including colon cancer, ...
Breast cancer classification
Trastuzumab plus adjuvant chemotherapy for operable HER2+ breast cancer. N Engl J Med. 2005; 353:1673-1684 and supplementary ... radiotherapy, and hormonal therapy found a strong correlation of the Oncotype classification with the likelihood of a complete ... breast cancers. Activation of androgen receptors appears to suppress breast cancer growth in ER+ cancer while in ER- breast it ... The grading of a cancer in the breast depends on the microscopic similarity of breast cancer cells to normal breast tissue, and ...
Breast cancer management
The breast has previously received radiotherapy The tumor is large relative to the size of the breast The patient has had ... adjuvant (after surgery) and neoadjuvant (before surgery). The mainstay of breast cancer management is surgery for the local ... Research is ongoing for the use of immunotherapy in breast cancer management. Management of breast cancer is undertaken by a ... which can complicate radiotherapy The patient lives in an area where radiotherapy is inaccessible The patient wishes to avoid ...
Metastatic breast cancer
Adjuvant radiotherapy follows surgical resection; this combined approach has been shown to prolong median survival up to 12 ... Radiotherapy is used in the treatment of metastatic breast cancer. The most common reasons for a patient with metastatic breast ... advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease ... Radiotherapy is essential in the treatment of brain metastases from breast cancer, as it halts tumor progression quickly and ...
Montague has served on the National Breast Cancer Task Force and with the National Surgical Adjuvant Breast Project. "An ... In 1973, she became a radiotherapy professor. Montague has been a pioneer in breast cancer research and treatment. She has been ... In 1959, Montague joined the radiotherapy department at the University of Texas MD Anderson Cancer Center under an American ...
Triple-negative breast cancer
Standard treatment is surgery with adjuvant chemotherapy and radiotherapy. As a variation, neoadjuvant chemotherapy is very ... Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of ... Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for ... Triple-negative breast cancer accounts for approximately 15%-25% of all breast cancer cases. The overall proportion of TNBC is ...
Jahanzeb M (August 2008). "Adjuvant trastuzumab therapy for HER2-positive breast cancer". Clin. Breast Cancer. 8 (4): 324-33. ... internal radiotherapy). Conventionally radiotherapy is given after the operation for breast cancer. Radiation can also be given ... Mouse models of breast cancer metastasis. References. *^ a b c d e f g h i j k l m "Breast Cancer Treatment (PDQ®)". NCI ... Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change ...
It is the most commonly reported complication in breast radiation therapy patients who receive adjuvant axillary radiotherapy ... for breast cancer after breast-conserving surgery, radiotherapy has been found to halve the rate at which the disease recurs.[7 ... "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of ... Preventive (adjuvant) doses are typically around 45-60 Gy in 1.8-2 Gy fractions (for breast, head, and neck cancers.) Many ...
Adenoid cystic carcinoma
Adjuvant or palliative radiotherapy is commonly given following surgery. For advanced major and minor salivary gland tumors ... This tumor most often occurs in the salivary glands, but it can also be found in many anatomic sites, including the breast, ... "Adenoid Cystic Carcinoma." [self-published source?] Laramore, GE (September 1987). "Fast neutron radiotherapy for inoperable ... "Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland ...
Vassar Brothers Medical Center
The Dyson Center at VBMC is affiliated with the National Surgical Adjuvant Breast and Bowel Project and conducts clinical ... stereotactic body radiotherapy (SBRT), and intensity-modulated radiation therapy (IMRT). The Dyson Breast Center is a full ... The second floor of the Vassar Ambulatory Surgery Center houses the Dyson Breast Center, a center for breast disease, breast ... The Dyson Breast Center features two 3D mammography units for use in the Breast Center, separate from the Center for Cancer ...
Paget's disease of the breast
In Paget's disease, the most common type of adjuvant therapy is radiation following breast-conservative surgery. Adjuvant ... "Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results". Cancer. 97 (9): 2142-9. doi ... Breast changes. There may or may not be a lump in the breast, and there may be redness, oozing and crusting, and a sore that ... A breast-conserving surgery consists in the removal of the nipple, areola and the part of the breast that is affected by cancer ...
Treatment of cancer
Radiotherapy is the use of high-energy rays, usually x-rays and similar rays (such as electrons) to treat disease. It works by ... In breast cancer, the survival rate of patients who receive neoadjuvant chemotherapy are no different to those who are treated ... Staging is a major determinant of prognosis and of the need for adjuvant therapy. Occasionally, surgery is necessary to control ... In children radiotherapy mostly causes long-term side effects such as hearing loss and blindness. Children who had received ...
Targeted intra-operative radiotherapy
... in the remaining breast or on the chest wall in a small proportion of women. Adjuvant radiotherapy is necessary if breast ... July 2010). "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an ... February 2014). "Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year ... Smyth, Chris (2014). "Single-dose radiotherapy eases breast cancer stress". The Times. Retrieved 26 July 2016. "Breast cancer ( ...
The Breast: Its Problems, Benign and Malignant: And How to Deal With Them. Houghton Mifflin, 1977. ISBN 978-0-395-25709-8.. ... He warned against reliance on radical surgery, and advocated less invasive surgery and more use of radiotherapy and ... Cancer treatment now is focused on limited surgery and adjuvant chemoradiotherapy rather than radical surgery, and medical ... He promoted these ideas widely, publishing Man, Mind & Medicine - The Doctor's Education in 1968, and The Breast: Its Problems ...
This has led to carboplatin based adjuvant therapy being generally preferred over adjuvant radiotherapy in clinical practice. ... in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited". ... Research has indicated that it is not less effective than adjuvant radiotherapy for this treatment, while having fewer side ... "Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial". Lancet. 366 (9482 ...
Adjuvant radiotherapy may also be used after surgical excision for liposarcoma. Rhabdomyosarcoma is treated with surgery, ... Common malignancies, such as breast, colon, and lung cancer, are almost always carcinoma. The term is from the Greek σάρξ sarx ... Radiotherapy is a second alternative although not as successful. Sarcomas are given a number of different names based on the ... radiotherapy, and/or chemotherapy. The majority of rhabdomyosarcoma patients have a 50-85% survival rate. Osteosarcoma is ...
Somatic evolution in cancer
Selective estrogen receptor modulators (SERMs) are a commonly used adjuvant therapy in estrogen-receptor positive (ERα+) breast ... Resistance to radiotherapy is also commonly observed. However, to date, comparisons of malignant tissue before and after ... "Measurement of steroid hormone receptors in breast cancer patients on tamoxifen". Breast Cancer Res. Treat. 26 (3): 237-46. doi ... Osborne CK; Osborne, C. Kent (November 1998). "Tamoxifen in the treatment of breast cancer". N. Engl. J. Med. 339 (22): 1609-18 ...
In the clinical context the orally active Razoxane subsequently was shown to prevent liver metastases in adjuvant treatment of ... Cade was a pioneer in radiotherapy at the Westminster Hospital and an Air Vice Marshall of the Royal Airforce whose invaluable ... long-term cardioprotection by Dexrazoxane preserving the myocardial reserves in breast cancer patients with no additional ... Visiting Professor at the Radiotherapy & Oncology Department, Westminster Hospital, London (now Imperial College) from 1972 to ...
Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used when there is little evidence ... primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. By contrast, other ... In males previously having undergone chemotherapy or radiotherapy, there appears to be no increase in genetic defects or ... These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells ...
Adjuvant radiotherapy in the treatment of breast cancer.
... survival and quality of life in patients with breast cancer have been evaluated. Following these studies, breast conserving ... Recent studies on the impact of adjuvant radiotherapy on local control, ... Recent studies on the impact of adjuvant radiotherapy on local control, survival and quality of life in patients with breast ... radiotherapy*, surgery. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Radiotherapy, Adjuvant. ...
Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation...
Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation ... Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation ... Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation ... Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation ...
6 Recommendations for further data collection | Intrabeam radiotherapy system for adjuvant treatment of early breast cancer |...
Evidence-based recommendations on using Intrabeam radiotherapy during breast-conserving surgery for adults with early breast ... Breast cancer Intrabeam radiotherapy system for adjuvant treatment of early breast cancer Technology appraisal guidance [TA501] ... who choose to have the Intrabeam radiotherapy system for adjuvant treatment of early invasive breast cancer during breast- ...
Clinical impact of irradiated lung volumetric modeling in adjuvant breast radiotherapy (RT) | European Respiratory Society
Clinical impact of irradiated lung volumetric modeling in adjuvant breast radiotherapy (RT). Abhay Javia, Sateesh Patel, Rajiv ... Clinical impact of irradiated lung volumetric modeling in adjuvant breast radiotherapy (RT) ... Clinical impact of irradiated lung volumetric modeling in adjuvant breast radiotherapy (RT) ... Clinical impact of irradiated lung volumetric modeling in adjuvant breast radiotherapy (RT) ...
Exercise as it relates to Disease/The Benefits of Resistance Training in Breast Cancer Patients Receiving Adjuvant Radiotherapy...
Exercise as it relates to Disease/The Benefits of Resistance Training in Breast Cancer Patients Receiving Adjuvant Radiotherapy ... This study involved 160 patients with breast cancer in stages 0-III during adjuvant radiotherapy. Participants were randomised ... Randomized, controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on ... a b c d e Van Vulpen J, Peeters P, Velthuis M, van der Wall E, May A. Effects of physical exercise during adjuvant breast ...
Magiran | Acute Skin and Pharynx Complications Following Adjuvant Hypofractionated Versus Conventional Radiotherapy in Patients...
... radiation therapy following surgery for breast cancer.MethodsDuring this prospective study, women who had undergone breast ... Incidence and severity of dermatitis was more common in those who received conventional radiotherapy in comparison to ... to overcome the quickly growing tumor cells as well as shortening whole treatment course in solid tumors such as breast cancers ... was a statistically significant difference in occurrence of dermatitis between the two groups of conventional radiotherapy and ...
External beam boost versus interstitial high-dose-rate brachytherapy boost in the adjuvant radiotherapy following breast...
... after breast-conserving treatment in women with early-stage breast cancer. MATERIAL AND METHODS: We analyzed the treatment ... External beam boost versus interstitial high-dose-rate brachytherapy boost in the adjuvant radiotherapy following breast- ... who underwent breast-conserving surgery and adjuvant whole breast irradiation (WBI; 50.4 Gy) and boost (HDR-BT: 10 Gy in one ... More News: Brachytherapy , Breast Cancer , Breast Conservation Surgery , Cancer , Cancer & Oncology , Cardiology , External ...
GMS | 27th German Cancer Congress Berlin 2006 | Postoperative adjuvant radiotherapy in breast cancer patients with 1-3 positive...
Postoperative adjuvant radiotherapy in breast cancer patients with 1-3 positive axillary lymph nodes: is there a role for ... Purpose: There is no consensus regarding adjuvant radiotherapy of periclavicular lymph nodes in patients with limited (1-3) ... Whole breast radiotherapy was performed in all patients (median total dose 50.4 Gy, single dose 1.8-2.0 Gy). Additionally, 68 ( ... Systemic adjuvant treatment was performed as follows: chemotherapy in 136 patients (57.6%) and antihormonal therapy in 193 ...
Role of Surgery and Adjuvant Radiotherapy in the Treatment of Breast Cancer Explored - The ASCO Post
Role of Surgery and Adjuvant Radiotherapy in the Treatment of Breast Cancer Explored. By Alice Goodman. September 10, 2015. ... response to neoadjuvant therapy into decision-making regarding the addition of adjuvant radiotherapy for patients with breast ... undergo randomization to receive postmastectomy radiotherapy or not or-in the case of breast-conserving surgery-to whole-breast ... "This study should help decide which patients should be treated with radiotherapy and whether radiotherapy can be avoided if the ...
Pulsed dose rate brachytherapy as the sole adjuvant radiotherapy after breast-conserving surgery of T1-T2 breast cancer : first...
Pulsed dose rate brachytherapy as the sole adjuvant radiotherapy after breast-conserving surgery of T1-T2 breast cancer: first ... Five external beam radiotherapy (EBRT) whole breast treatments to 50 Gy versus five accelerated partial breast irradiations ( ... PDR APBI as the adjuvant RT treatment to breast conserving surgery after early breast cancer was studied. Between 1994-2004 we ... Brachytherapy; Pulsed dose rate; Breast cancer; Accelerated partial breast irradiation; Cosmetics; Outcome; Radiotherapy ...
Adjuvant radiotherapy and chemotherapy in breast cancer: 30 year follow-up of survival | BMC Cancer | Full Text
... of adjuvant treatment in patients with primary operable breast cancer has rarely been examined. A randomised clinical trial of ... 260 (81%) patients died, 204 (78%) from breast cancer. Cancer specific survival (SE) at 10 years, 20 years and 30 years was 41 ... socio-economic deprivation and adjuvant treatment. Both age (HR 1.63, 95% CI 1.19-2.22) and involved lymph nodes (HR 1.59, 95% ... or both on women with primary operable breast cancer (n = 322) was followed-up for a median of 27 years. ...
Adjuvant Radiotherapy Use Questioned for Low-Risk Breast Cancer in Older Women | OncologyPRO
Adjuvant radiation offers relatively small benefit for older women undergoing breast-conserving surgery and endocrine treatment ... Adjuvant Radiotherapy Use Questioned for Low-Risk Breast Cancer in Older Women. ... Adjuvant Radiotherapy Use Questioned for Low-Risk Breast Cancer in Older Women ... for radiotherapy in women aged 65 years or older with low-risk breast cancer who undergo breast-conserving surgery and adjuvant ...
Locally advanced breast cancer treated with neoadjuvant chemotherapy and adjuvant radiotherapy: a retrospective cohort analysis...
NAC was mostly anthracycline and taxane-based; radiotherapy consisted of 50 Gy to the breast/chest wall and regional lymph ... All LABC patients treated for curative intent with NAC, surgery, and adjuvant radiotherapy at our institute between January ... surgery and adjuvant radiotherapy and to correlate these outcomes with tumour response after NAC using multiple response ... is increasingly used to treat locally advanced breast cancer (LABC). Improved response to NAC correlates with better survival ...
A Multi-Institutional Analysis of Adjuvant and Salvage Radiotherapy After Radical Prostatectomy | OncoLink
Bladder Cancer Bone Cancers Bone Metastases Brain Metastasis Brain Tumors Breast Cancer ... A Multi-Institutional Analysis of Adjuvant and Salvage Radiotherapy After Radical Prostatectomy. Reviewer: John Wilson, MD ... Prostate cancer occasionally recurs after surgery, and some patients are recommended to have ART (adjuvant radiotherapy), or ... Conventional Radiotherapy Three-Dimensional Conformal Radiotherapy Rising PSA Post-prostatectomy Post-Radiation Therapy ...
Breast cancer overview --Doctors Lounge
... and radiotherapy to the breast may not be necessary.. Adjuvant tamoxifen therapy. Adjuvant tamoxifen therapy was shown to ... Adjuvant radiation therapy following breast conservation. Breast conservation should be followed by radiation as part of the ... Breast cancer is a cancer that starts in the cells of the breast. Worldwide, breast cancer is the second most common type of ... of all breast cancer diagnoses. Inflammatory breast cancer causes the breast to appear swollen and inflamed. This appearance is ...
Eyes on Evidence: Benefit of adjuvant radiotherapy in breast cancer - Library & Knowledge Service blog
In men breast cancer is rare, with about 260 cases diagnosed and 68 deaths in Englandand Waleseach year. Current treatment: ... Treatment for breast cancer usually involves surgery to… ... Breast cancer is the most common cancer affecting women in ... Eyes on Evidence: Benefit of adjuvant radiotherapy in breast cancer. Overview: Breast cancer is the most common cancer ... of the women who had radiotherapy. The effect of radiotherapy on breast cancer mortality was evident 15 years after breast ...
Biclutamide ('Casodex') 150 mg as Adjuvant to Radiotherapy in Localized or Locally Advanced Prostate Cancer | OncoLink
Bladder Cancer Bone Cancers Bone Metastases Brain Metastasis Brain Tumors Breast Cancer ... Biclutamide (Casodex) 150 mg as Adjuvant to Radiotherapy in Localized or Locally Advanced Prostate Cancer. Ryan Smith, MD ... Biclutamide ("Casodex") 150 mg as Adjuvant to Radiotherapy in Localized or Locally Advanced Prostate Cancer ... This is a study to evaluate the use of biclutamide as an immediate therapy or as adjuvant to therapy of curative intent in non- ...
New Horizons in Radiotherapy for Older People
Adjuvant. Breast. No. Majority of cases after breast conservation, some cases post mastectomy. ... Can be used neo-adjuvant Adjuvant treatment uncommon. Non-melanoma skin cancer. Alternative to surgery. Common, indications ... SABR (stereotactic ablative body radiotherapy) is very high radiotherapy dose accurately delivered to a small area in a small ... Stereotactic Ablative Body Radiotherapy (SABR), proton therapy, MR guided radiotherapy, as well as better image guidance during ...
Search results | NICE
Intrabeam radiotherapy system for adjuvant treatment of early breast cancer (TA501) Evidence-based recommendations on using ... Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer (TA619) Evidence- ... Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine ... HER2-negative locally advanced or metastatic breast cancer ... Intrabeam radiotherapy during breast-conserving surgery in ...
Adjuvant Chemotherapy in Treating Women Who Have Undergone Resection for Relapsed Breast Cancer; Chemotherapy as Adjuvant for...
Uninvolved (clear) margins and planned radiotherapy with at least 40 Gy for patients who had no prior adjuvant radiotherapy ... stage I breast cancer. stage II breast cancer. stage IIIA breast cancer. stage IIIB breast cancer. stage IIIC breast cancer. ... Adjuvant Chemotherapy in Treating Women Who Have Undergone Resection for Relapsed Breast Cancer; Chemotherapy as Adjuvant for ... who received prior adjuvant radiotherapy are not required to receive further radiotherapy ...
Assessing Women's Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer - Full Text...
stage II breast cancer. stage IA breast cancer. stage IB breast cancer. ... Assessing Womens Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer. This study has ... RATIONALE: Adjuvant therapy given after surgery for early breast cancer may cause infertility. Assessing young womens ... Breast Neoplasms. Infertility. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Genital Diseases, Male. Genital ...
Metastatic breast cancer - Wikipedia
Adjuvant radiotherapy follows surgical resection; this combined approach has been shown to prolong median survival up to 12 ... Radiotherapy is used in the treatment of metastatic breast cancer. The most common reasons for a patient with metastatic breast ... advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease ... Radiotherapy is essential in the treatment of brain metastases from breast cancer, as it halts tumor progression quickly and ...
Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program. -...
... half received adjuvant radiotherapy; 29.8% (neo)adjuvant chemotherapy and 76.8% adjuvant endocrine therapy (ET), mostly ... A) Breast cancer-specific mortality Kaplan-Meier curves for all patients by age at diagnosis. Due to missing data, for breast ... Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program.. ... Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program ...
Adjuvant therapy for breast cancer | Pyramid Clinic
You will decide with your oncologist on adjuvant treatment such as chemotherapy or radiation. ... Adjuvant therapy begins after surgical removal of the tumour. ... Radiotherapy takes a period of five weeks. During this time, ... Hormonal therapy is currently used in some cases as an adjuvant treatment for breast cancer and to treat metastasis. The aim is ... Breast-conserving surgery necessarily includes local radiotherapy of the residual mammary gland and possibly the lymph drainage ...
Vorschau | Kommission Mamma | Leitlinien & Empfehlungen | Leitlinien & Stellungnahmen | AGO - Die Arbeitsgemeinschaft...
Adjuvant Radiotherapy. Lasted update: 02.03.2020. DOWNLOADDOWNLOAD WITH REFERENCES. Supportive Care. Lasted update: 02.03.2020 ... Chemotherapy with or without Targeted Drugs in Metastatic Breast Cancer. Lasted update: 02.03.2020 ... Adjuvant Endocrine Therapy in Pre- and Postmenopausal patients. Lasted update: 02.03.2020 ...
Partial breast brachytherapy: MedlinePlus Medical Encyclopedia
Brachytherapy for breast cancer involves placing radioactive material in the area where breast cancer has been removed from the ... Permanent breast seed implant; PBSI; Low-dose radiotherapy - breast; High-dose radiotherapy - breast; Electronic balloon ... Carcinoma of the breast - partial radiation therapy; Brachytherapy - breast; Adjuvant partial breast radiation - brachytherapy ... Breast cancer treatment (adult) (PDQ) - health professional version. www.cancer.gov/types/breast/hp/breast-treatment-pdq. ...
Breast Surgery - Print and E-Book - 6th Edition
Purchase Breast Surgery - Print and E-Book - 6th Edition. Print Book & E-Book. ISBN 9780702072413, 9780702072390 ... Neoadjuvant therapy for breast cancer including surgical considerations. *Adjuvant radiotherapy for breast cancer ... The role of adjuvant systemic therapy in patients with operable breast cancer ... Consultant Breast Surgeon, NHS Lothian, Edinburgh Breast Unit, Western General Hospital, Edinburgh and St Johns Hospital, ...
Early, Advanced Breast Cancer Treatment (Surgery, Chemotherapy) | Healthhype.com
The main aim of adjuvant radiotherapy is to prevent recurrence.. *Following a breast conservation surgery, postoperative ... However, radiotherapy is not combined with lymph node clearance.. Adjuvant Systemic Therapy. Adjuvant systemic therapy with a ... Local therapy helps to remove or destroy cancer in the breast by means of surgery or radiotherapy. In systemic therapy, cancer ... Adjuvant therapy is treatment administered after the main therapy. This may include radiation therapy (radiotherapy), ...
Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant...
... heart substructures based on a pre-existing guideline was made.Patients and methodsHeart substructures of 16 left-sided breast ... breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE- ... Risk of ischemic heart disease in women after radiotherapy for breast cancer.. Sarah C. Darby, Marianne Ewertz, +13 authors Per ... of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy. @ ...
Adjuvant breast inversely planned intensity-modulated radiotherapy with simultaneous integrated boost for early stage breast...
Adjuvant breast inversely planned intensity-modulated radiotherapy with simultaneous integ Adjuvant breast inversely planned ... To report early toxicity and 5-year clinical outcomes of adjuvant breast inversely planned intensity-modulated radiotherapy ... All patients underwent IMRT-SIB treatment to irradiate the whole breast and the tumor bed. Doses to whole breast and surgical ... after breast-conserving surgery for early stage breast cancer patients. PATIENTS AND METHODS:. In all, 467 patients including ...
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- In elderly women postoperative radiotherapy should not be withheld. (biomedsearch.com)
- Postoperative adjuvant radiotherapy in breast cancer patients with 1-3 positive axillary lymph nodes: is there a role for periclavicular lymph node irradiation (PLNI)? (egms.de)
- 236 breast cancer patients with newly diagnosed T1/T2 tumors and 1-3 involved axillary lymph nodes received postoperative radiotherapy following breast conservative surgery between 1997 and 2000. (egms.de)
- Women with histological involvement of the axillary nodes were randomized to receive either: conventional postoperative radiotherapy, chemotherapy alone or radiotherapy followed by chemotherapy. (biomedcentral.com)
- Following a breast conservation surgery, postoperative radiotherapy to the affected breast is essential to reduce the risk of recurrence. (healthhype.com)
- To assess the role of the 21-gene recurrence score (RS) assay on decision-making of postoperative radiotherapy (RT) following breast-conserving surgery (BCS) in elderly women with early-stage breast cancer. (cdc.gov)
- Breast cancer-specific survival in patients who had or did not have postoperative radiotherapy in the entire cohort before (A) and after (B) propensity score matching. (cdc.gov)
- Breast cancer-specific survival in patients who had or did not have postoperative radiotherapy in the low-risk group before (A) and after (B) propensity score matching. (cdc.gov)
- To compare the rates of overall survival (OS), disease-free survival (DFS) and toxicity in different techniques of postoperative radiotherapy for stage IA endometrioid adenocarcionoma of endometrium, histological grades 1and 2. (scielo.br)
- We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. (nih.gov)
- The Breast Cancer Group of the Japanese Radiation Oncology Study Group conducted a nationwide questionnaire survey on the clinical practice of postoperative radiotherapy for breast-conserving treatmen. (bioportfolio.com)
- A five split-field three dimensional conformal technique versus an anterior-posterior on in postoperative radiotherapy for gastric carcinoma: a multicenter comparative study using quality of life measurements as well as clinical and dosimetric parameters. (nih.gov)
- Previous randomized experimental studies have shown that concurrent chemoradiotherapy was superior to single radiotherapy and postoperative adjuvant radiotherapy , but the side effects should not be neglected. (thefreedictionary.com)
- For the purposes of this article 'locally advanced breast cancer' refers to clinical stage 3 disease which may include involvement of supraclavicular nodes (Table I). The postoperative treatment of T1--2 tumours which are found to be pathologically stage 3 due to 4 or more nodes being involved with cancer, will be covered elsewhere. (thefreelibrary.com)
- Treatment for early-stage breast cancer uses postoperative radiation therapy to destroy small microscopic deposits of residual disease to improve survival and prevent recurrence. (cancersupportivecare.com)
- The patient went on to receive four cycles of adjuvant chemotherapy (paclitaxel) and postoperative radiotherapy. (mja.com.au)
- Depending on the type and stage of breast cancer, this may be followed by radiotherapy, endocrine therapy, biological therapy or chemotherapy. (wordpress.com)
- The TEAM study is a randomised phase III clinical trial comparing the efficacy of the aromatase inhibitor exemestane versus the current "gold standard" treatment tamoxifen as adjuvant endocrine therapies for hormone sensitive early breast cancer in postmenopausal women. (scienceblog.com)
- Anti-estrogen therapy has been shown to reduce mammographic breast density (MD). We hypothesized that a short-term change in breast density may be a surrogate biomarker predicting response to adjuvant endocrine therapy (ET) in breast cancer. (biomedcentral.com)
- Adjuvant endocrine therapy is the most effective systemic treatment modality for patients with hormone receptor (ER)-positive breast cancer, although many patients experience tumor recurrence during or after completion of endocrine therapy. (biomedcentral.com)
- Identifying factors that can predict disease recurrence early during adjuvant treatment may result in a more tailored strategy for patients likely to be endocrine resistant and may improve their overall outcomes. (biomedcentral.com)
- However, no studies to date have addressed the association between MD reduction and the efficacy of adjuvant endocrine treatment in breast cancer patients. (biomedcentral.com)
- Using quantitative imaging analysis software to assess serial changes in MD, we investigated the association between the degree of MD reduction and long-term breast cancer recurrence in ER-positive breast cancer patients who received adjuvant endocrine therapy. (biomedcentral.com)
- 3) they had bilateral breast cancer, or 4) distant metastasis was observed before the start of endocrine therapy. (biomedcentral.com)
- All arms included radiotherapy but no endocrine therapy. (aacrjournals.org)
- The multidisciplinary features (systemic treatment، endocrine therapy، and surgery)، patient profile (history of underlying diseases، age، and habits)، and irradiation-associated parameters are the factors affecting safe adjuvant radiotherapy. (magiran.com)
- However, because ECS may predict for locoregional failure our results cannot rule out that these patients may preferentially benefit from adjuvant periclavicular irradiation. (egms.de)
- A dosimetrical analysis showed that the partial breast irradiation covered a median of 31% of the total breast volume. (diva-portal.org)
- CONCLUSIONS: Local outcome is favourable and very similar to other published studies of accelerated partial breast irradiation. (diva-portal.org)
- Technological advances of relevance include Intensity Modulated Radiotherapy (IMRT), Volumetric Modulated Arc therapy (VMAT), Stereotactic Ablative Body Radiotherapy (SABR), proton therapy, MR guided radiotherapy, as well as better image guidance during irradiation in order to improve precision and accuracy. (medscape.com)
- Strain Imaging Detects Dose-Dependent Segmental Cardiac Dysfunction in the Acute Phase After Breast Irradiation. (semanticscholar.org)
- However, the current standard is CT followed by whole-breast-irradiation (WBI). (biomedcentral.com)
- Prone position is a favorable alternative for irradiation of mammary gland in patients with pendulous breasts and in our series was adopted in 71% of the cases. (biomedcentral.com)
- The majority of patients with early-stage breast cancer are candidates for breast-conservation therapy followed by whole-breast irradiation (WBI), typically delivered in the supine position. (biomedcentral.com)
- In particular, irradiation after breast-conserving surgery (BCS) in women with large and/or pendulous breasts is a challenge for radiation oncologists. (biomedcentral.com)
- Our institution developed a method for delivering breast three dimensional conformal radiotherapy (3D-CRT) in the prone position to address the technical challenges associated with irradiation of large and pendulous breasts. (biomedcentral.com)
- The study was designed to evaluate the feasibility and safety of hypofractionated whole-breast irradiation with simultaneously integrated boost for early-stage breast cancer after breast c. (bioportfolio.com)
- METHODS: The author searched the MEDLINE database for articles on breast reconstruction and radiation therapy published between January of 2008 and June of 2011 and reviewed the abstracts of those articles to identify articles with information about the impact of irradiation on implant-based breast reconstruction. (biomedsearch.com)
- To maximize the therapeutic risk/benefit ratio of RT for breast cancer, multiple irradiation techniques have been developed to decrease dose to the heart, including breath-hold technique, prone positioning, heart block, utilizing electron beam with photons, and intensity modulated RT ( 3 ). (frontiersin.org)
- Cutaneous، cardiac، and pulmonary toxicity are the main complications of adjuvant breast irradiation. (magiran.com)
- Results of two studies of breast cancer reported in the New England Journal of Medicine last week have prompted the authors of an accompanying editorial to propose that lumpectomy plus tamoxifen but without local irradiation "is a realistic choice" for some women over the age of 70 years. (bmj.com)
- Few studies have been done on women with existing cardiac disease, who received breast irradiation, and whether there was an increase in additional cardiac toxic events. (cancersupportivecare.com)
- A comparison of brachytherapy techniques for partial breast irradiation. (limamemorial.org)
- Patients and methods: After surgery, patients submitted to adjuvant radiotherapy with irradiation technique assessment using a semi-quantitative score evaluating the design of radiation fields including five objectives: breadth of chest wall coverage, homogeneity, minimization of lung irradiation, avoidance of heart and Dmax. (omicsonline.org)
Starting adjuvant chemotherapy1
- Following these studies, breast conserving surgery with subsequent radiation therapy is the standard treatment for early breast cancer. (biomedsearch.com)
- Here, we compared the incidence of dermatitis and pharyngitis among patients undergoing HF versus conventional fractionationated (CF) radiation therapy following surgery for breast cancer. (magiran.com)
- This study aims to compare the dosimetric data of local tumor's bed dose escalation (boost) with photon beams (external beam radiation therapy - EBRT) versus high-dose-rate interstitial brachytherapy (HDR-BT) after breast-conserving treatment in women with early-stage breast cancer. (medworm.com)
- A retrospective meta-analysis found that adding adjuvant radiation therapy to neoadjuvant treatment improves outcomes in women with operable and nonoperable breast cancer, regardless of whether they achieve pathologic complete response to neoadjuvant therapy. (ascopost.com)
- It is not yet known whether chemotherapy is effective in treating women who have undergone surgery and radiation therapy for relapsed breast cancer. (clinicaltrials.gov)
- Consequently, adjuvant treatment regimens such as whole brain radiation therapy (WBRT) and/or stereotactic radiation therapy (SRS) have been used to improve local control after surgical resection. (springer.com)
- Brachytherapy delivers radiation therapy directly to where cancer cells inside the breast are located. (medlineplus.gov)
- Intraoperative radiation therapy is delivered in the operating room while you are asleep after breast tissue is removed. (medlineplus.gov)
- This approach is called adjuvant (additional) radiation therapy because it is adding a treatment beyond surgery. (medlineplus.gov)
- Because these techniques are not as well studied as whole breast radiation therapy, there is not full agreement about who is most likely to benefit. (medlineplus.gov)
- This may include radiation therapy (radiotherapy), chemotherapy, hormone therapy, or targeted therapy after surgery for breast cancer. (healthhype.com)
- Conclusions: Our study provides indirect evidence of a benefit from radiation therapy in preventing local breast cancer relapse, particularly among node-negative patients with tumors that express elevated levels of the p53 or GST-π proteins or that express little or no Bcl-2 protein. (elsevier.com)
- Long-term follow-up of historic radiation therapy trials for breast cancer has demonstrated a potential increase in cardiac mortality. (eurekalert.org)
- However, these studies used earlier modes of radiation therapy including Cobalt and orthovoltage radiotherapy, and did not employ CT-based planning, which allows for greater cardiac avoidance. (eurekalert.org)
- The NCBD is more than two times larger than the Surveillance, Epidemiology and End Results (SEER) database, and the NCBD contains data not found in SEER, including histopathologic data and specific treatment information such as sequencing of therapies, dose, technique (e.g., intensity modulated radiation therapy vs. brachytherapy) and target (e.g., breast only vs. breast and regional nodes). (eurekalert.org)
- All patients had a diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of any histologic subtype, and received external beam radiation therapy after breast-conserving surgery. (eurekalert.org)
- Of the patients with invasive disease, 85 percent (257,707) were treated with radiation therapy to the breast only with a median dose of 50.4 Gy. (eurekalert.org)
- Current status of implant-based breast reconstruction in patients receiving postmastectomy radiation therapy. (biomedsearch.com)
- BACKGROUND: Increasing numbers of patients with breast cancer are being treated with postmastectomy radiation therapy. (biomedsearch.com)
- The author reviewed the literature to determine the clinical impact of this increasing use of postmastectomy radiation therapy in patients with breast cancer who desire implant-based breast reconstruction. (biomedsearch.com)
- In general, patients with early-stage breast cancer undergo primary breast cancer surgery with or without radiation therapy. (scirp.org)
- In the last quarter century, survival after breast cancer has markedly increased because of advances in earlier detection, hormonal treatments, and chemotherapy and improvements in radiation therapy (RT). (aacrjournals.org)
- In this study, the researchers wanted to see if using BOTH chemotherapy AND radiation therapy before surgery (called neoadjuvant chemoradiation) would reduce the risk of locally advanced breast cancer coming back in the breast area compared to only giving chemotherapy before surgery. (breastcancer.org)
- Each woman received the chemotherapy medicine paclitaxel and radiation therapy before breast cancer surgery. (breastcancer.org)
- Newer and improved radiotherapy techniques have helped to reduce toxicity, and using lower doses and limiting extent of chemotherapy have both reduced cardiac toxic side effects (Utilizing Three-DCD based treatment planning to give a more precise radiation therapy target for individual anatomic planning has helped control cardiac dose volume, as well as limit lung damage. (cancersupportivecare.com)
- Coronary Heart Disease and Risk Factors in Patients Treated with Radiation Therapy for Early Breast Cancer) showed that the time from radiation therapy to first cardiac event was 3.7 years, and a ten-year cumulative incidence of myocardial infarction was 1.2%, lower rates than were expected. (cancersupportivecare.com)
- Radiation therapy remains a critical component of breast cancer therapy, and follow-up medical care and precautions are merited. (cancersupportivecare.com)
- Clinical Oncology and organ at risk in supraclavicular (SC) nodal radiation therapy (RT) for breast cancer. (who.int)
- The radiation therapy is given after breast-conserving surgery. (limamemorial.org)
- This approach is called adjuvant (additional) radiation therapy. (limamemorial.org)
- Hormonal therapy is currently used in some cases as an adjuvant treatment for breast cancer and to treat metastasis. (pyramide.ch)
- Treatment of metastatic breast cancer depends on location of the metastatic tumours and includes surgery, radiation, chemotherapy, biological, and hormonal therapy. (wikipedia.org)
- Background: In clinical breast cancer research, the utility of certain biomarkers as predictors of response to surgery, chemotherapy, or hormonal therapy has been studied intensively. (elsevier.com)
- This may can include chemotherapy, radiotherapy or hormonal therapy. (drugs.com)
- BETHESDA, Md-Speakers at the National Institutes of Health Consensus Development Conference on Adjuvant Therapy for Breast Cancer will address the data on adjuvant chemotherapy, hormonal therapy, and other aspects of postsurgical treatment. (cancernetwork.com)
- For which patients should adjuvant hormonal therapy be recommended? (cancernetwork.com)
- For the validation set, 221 ER-positive breast cancers treated with adjuvant hormonal therapy for 5 years with or without chemotherapy at our hospital were included. (springermedizin.de)
- radiotherapy, hormonal therapy and targeted reast cancer is considered the commonest therapy. (who.int)
- hormonal therapy drugs which are often prescribed after active treatment (ie surgery, chemotherapy, and/or radiotherapy) is completed. (bcna.org.au)
- Adjuvant radiotherapy in the treatment of breast cancer. (biomedsearch.com)
- 6.1 Clinicians should enter details about all patients who choose to have the Intrabeam radiotherapy system for adjuvant treatment of early invasive breast cancer during breast-conserving surgical removal of the tumour in the NHS onto a national register. (nice.org.uk)
- One treatment option for breast cancer is radiotherapy, which is a specifically targeted treatment used after breast surgery. (wikibooks.org)
- Breast cancer patients undergoing radiotherapy treatment commonly complain of moderate to severe fatigue, with some patients still experiencing fatigue up to a year after treatment ends. (wikibooks.org)
- Outcome measures were recorded prior to starting radiotherapy treatment, post-radiotherapy (at 7 weeks) and post intervention (week 13) in both groups. (wikibooks.org)
- Hypofractionated radiotherapy (HF) method was introduced to overcome the quickly growing tumor cells as well as shortening whole treatment course in solid tumors such as breast cancers. (magiran.com)
- Two separate retrospective studies have further refined our understanding of the respective contributions of surgery and radiotherapy in the treatment of breast cancer. (ascopost.com)
- The long term outcome (more than 15 years) of adjuvant treatment in patients with primary operable breast cancer has rarely been examined. (biomedcentral.com)
- Presence of more than 3 involved lymph nodes increased cancer-specific mortality (HR 1.88, 95% CI 1.34-2.63) after adjustment for age, socio-economic deprivation and adjuvant treatment. (biomedcentral.com)
- Prior to the introduction of chemotherapy the mainstay of treatment was based on surgery and radiotherapy. (biomedcentral.com)
- In contrast, the long term outcome of such adjuvant treatment in these patients is less clear. (biomedcentral.com)
- Current treatment: Treatment for breast cancer usually involves surgery to remove part, or all, of the breast. (wordpress.com)
- Radiotherapy is an effective, albeit underutilised, treatment for cancer in older adults, especially for those who are surgically inoperable or for whom chemotherapy poses too great a risk. (medscape.com)
- This article synthesises the basics of how radiotherapy works, recent developments in the field and considers how this treatment modality may be adapted in an older patient population or may evolve in the future. (medscape.com)
- Radiotherapy is an effective treatment for many cancers, both in a curative and palliative setting. (medscape.com)
- Many patients have limited knowledge of radiotherapy prior to treatment and may have negative perceptions based on stories from friends, family and the press. (medscape.com)
- The oncologist decides on the necessary adjuvant treatment and medication based on the size of the tumour, the patient's age, whether the axillary lymph nodes are affected, and the biological and microscopic features of the cancer cells. (pyramide.ch)
- Chemotherapy is normally used as an adjuvant/post-operative treatment. (pyramide.ch)
- European Organisation for Research and Treatment of Cancer- Breast Cancer Group, Toronto, Canada. (nih.gov)
- The form of treatment for breast cancer depends on the clinical stage of the cancer at the time of diagnosis. (healthhype.com)
- For breast cancer, surgery is the most common form of treatment. (healthhype.com)
- Adjuvant therapy is treatment administered after the main therapy. (healthhype.com)
- Tamoxifen , a selective estrogen receptor modulator, is most commonly used for hormone treatment of breast cancer. (healthhype.com)
- Adjuvant chemotherapy may be given following curative treatment by surgery and radiotherapy. (healthhype.com)
- Background and purposeIn our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. (semanticscholar.org)
- All patients underwent IMRT-SIB treatment to irradiate the whole breast and the tumor bed . (bvsalud.org)
- Much less research has been done on the relevance of biologic predictors of response to radiotherapy, which represents an effective local-regional treatment for breast cancer. (elsevier.com)
- This treatment is not standard and is more commonly used for locally advanced breast cancer. (biomedcentral.com)
- The study compares 2 adjuvant treatments using CCRT, the first with anthracycline (group A) and the second with CMF (group B). The CT treatment was repeated every 21 days for 6 courses and the total delivered dose of RT was 50 Gy, divided as 2 Gy daily fractions. (biomedcentral.com)
- A review of the impact of exercise on treatment related fatigue among patients receiving adjuvant radiotherapy for breast cancer. (ulster.ac.uk)
- Fingerprint Dive into the research topics of 'A review of the impact of exercise on treatment related fatigue among patients receiving adjuvant radiotherapy for breast cancer. (ulster.ac.uk)
- Surgeons should strongly consider alternative methods of breast reconstruction, such as autologous-based reconstruction, as an alternative for patients who will require radiotherapy as part of their treatment protocol. (ps-rc.org)
- However, supine WBI does have limitations such as lateral dislocation of breast, accentuation of the infra-mammary folds, and inclusion of lung and heart portion in treatment plan. (biomedcentral.com)
- Patients submitted to adjuvant teletherapy showed very high toxicity, which contraindicates that treatment for those patients. (scielo.br)
- Surgery is the primary treatment for stage 1 endometrial cancer, and radiotherapy can be used as adjuvant treatment. (scielo.br)
- Medical literature has not defined the best adjuvant treatment for stage 1A endometrial cancer, histological grades 1 and 2 1 . (scielo.br)
- However, this relationship has been underdeveloped among low-income women in the community who may face barriers in accessing adjuvant treatment and post-treatment surveillance. (nih.gov)
- Lack of adjuvant RT may be a proxy for inadequate access to care and poor cancer surveillance after treatment. (nih.gov)
- There is conflicting information over prognosis for the various subtypes but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required. (wikipedia.org)
- Standard treatment is surgery with adjuvant chemotherapy and radiotherapy. (wikipedia.org)
- The purpose of this study is to determine whether concomitant radiotherapy and trastuzumab (patients treated for early breast cancer) is really safe for the heart even years after treatment and if the investigators should use these two treatments concomitantly without additional harm. (clinicaltrials.gov)
- The investigators know from the studies, that were already published, that for HER2 positive early breast cancer patients in adjuvant treatment concomitant radiotherapy and trastuzumab is safe during the treatment. (clinicaltrials.gov)
- we will compare LVEF (LVEF 1) measured before treatment with adjuvant Trastuzumab and concomitant Radiotherapy of breast/thoracic wall with LVEF (LVEF 2) measured at follow up (after adjuvant treatment) outpatient examination. (clinicaltrials.gov)
- Adjuvant therapy for breast cancer is any treatment given after primary treatment to increase the chance of long-term survival. (drugs.com)
- On the other hand, there is not a specific adjuvant or neoadjuvant treatment for these patients. (clinicaltrials.gov)
- Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. (bioportfolio.com)
- Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment. (bioportfolio.com)
- Physicians specializing in the treatment of cancer by RADIOTHERAPY. (bioportfolio.com)
- Our study evaluated skin and subcutaneous toxicity analyzing its correlation with patient- and treatment-related factors in a large mono-institutional series of women with early stage breast cancer tr. (bioportfolio.com)
- To evaluate acute toxicity and cosmetic outcomes of hypofractionated simultaneous integrated boost (SIB) as adjuvant treatment after breast-conserving surgery and adjuvant chemotherapy and to review t. (bioportfolio.com)
- Due to the inefficiency of adjuvant therapy , surgery remains the only effective treatment. (thefreedictionary.com)
- At the 2017 San Antonio Breast Cancer Symposium (SABCS), the International Breast Cancer Study Group (IBCSG) and its collaborators presented the 8-year updates of the key modern trials of ovarian function suppression after local treatment for young women with resected breast cancer. (ascopost.com)
- As first-line treatment for metastatic breast cancer, the oral taxane tesetaxel produced a 45% confirmed response rate and was well tolerated, producing little alopecia or neuropathy, according to Andrew D. Seidman, MD , and colleagues from several cancer centers. (ascopost.com)
- An examination of treatment patterns and outcomes associated with receipt of adjuvant/neoadjuvant therapy among elderly HR + HER2-breast cancer patients was undertaken. (scirp.org)
- Surgery is usually the first treatment for mucinous breast cancer. (breastcancercare.org.uk)
- You are being asked to take part in this study because you have received treatment to your breast, lung or prostate (the first location of your cancer). (cityofhope.org)
- You have received treatment to either your breast, lung, or prostate (the first location of your cancer). (cityofhope.org)
- The goal of the trial was to evaluate treatment with a beta-blocker and/or angiotensin-receptor blocker (ARB) among patients with breast cancer undergoing anthracycline chemotherapy. (acc.org)
- It's a study out of Alberta, specifically the University of Alberta and the Cross Cancer Institute and is entitled simply Outcome analysis of breast cancer patients who declined evidence-based treatment . (scienceblogs.com)
- Any patient who has completely refused the recommended standard primary treatment plan following biopsy confirmation of breast cancer is considered as refusal of standard treatment. (scienceblogs.com)
- Primary treatment could be surgery, neoadjuvant radiotherapy or chemotherapy. (scienceblogs.com)
- Among the 105 women, only 5 women (5%) had the cancer come back in the breast area during the first 5 years after treatment. (breastcancer.org)
- If you've been diagnosed with locally advanced breast cancer and are developing a treatment plan with your doctor, you might want to discuss this study as you plan. (breastcancer.org)
- radiotherapy used in addition to surgical resection or chemotherapy in the treatment of cancer. (thefreedictionary.com)
- Surgery with or without adjuvant radiotherapy is the treatment of choice in SMM. (thefreedictionary.com)
- Here, we evaluate the association of HER2-enriched with pathological response (pCR) and gene expression changes in pre- and post-treatment paired samples in HER2-positive breast cancer patients treated outside of a clinical trial. (frontiersin.org)
- Expression of 105 breast cancer-related genes, including the PAM50 genes, was determined in available pre-and post-treatment formalin-fixed paraffin-embedded tumor samples using the nCounter platform. (frontiersin.org)
- Significant advances have occurred in the treatment of HER2-positive breast cancer that have dramatically improved survival and changed its natural history ( 1 - 6 ). (frontiersin.org)
- The primary hypothesis in this formal prospective-retrospective analysis was to assess interaction between subtype (Luminal A vs. other) and treatment (chemotherapy vs. not) for the primary endpoint (10-year invasive disease-free survival) of a breast cancer trial randomizing women to adjuvant chemotherapy, analyzed in multivariate Cox proportional hazards models using the Wald interaction test. (aacrjournals.org)
- The Danish Breast Cancer Cooperative Group 77B clinical trial randomized 1,072 premenopausal women to no systematic treatment (control), levamisole, cyclophosphamide, or cyclophosphamide-methotrexate-fluorouracil arms. (aacrjournals.org)
- Conservative treatment in early-stage breast cancer is considered a standard approach. (magiran.com)
- Combined modality treatment using chemotherapy, surgery and radiotherapy is regarded as preferred treatment. (thefreelibrary.com)
- 10) In stage 3, radiotherapy usually includes treatment of at least the chest wall and supraclavicular fields. (thefreelibrary.com)
- Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. (springer.com)
- The adjuvant treatment of breast cancer has become standard of care. (springer.com)
- In all adjuvant settings, significant numbers of patients receive treatment who would have otherwise been cured by surgery alone. (amazonaws.com)
- The use of radiotherapy in these circumstances had been controversial, with treatment decisions based on retrospective, non-randomised studies, the Australian and New Zealand Melanoma Trials Group and the Trans-Tasman Radiation Oncology Group researchers noted in Lancet Oncology. (amazonaws.com)
- The taxanes, paclitaxel, docetaxel and nab-paclitaxel, are among the most active cytotoxic agents for treatment of breast cancer. (amazonaws.com)
- Choice of optimal adjuvant treatment has been based on present debates, doubts and commit offence against processing or existing evidences. (elitmed.hu)
- Present paper try to give a summary of adjuvant treatment courses for early breast cancer in consideration of last results of research since then. (elitmed.hu)
- Peripheral neuropathy (PN) is one of the most frequent toxicities associated with taxane use for the treatment of early-stage breast cancer. (deepdyve.com)
- The findings of the review clearly demonstrated a lack of information about PN persistence in early-stage breast cancer patients beyond the initial treatment period. (deepdyve.com)
- For more information, see Breast Cancer , HER2 Breast Cancer , Breast Cancer Treatment Protocols and the image below. (medscape.com)
- Adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry. (duke.edu)
- Adjuvant radiotherapy is considered one of treatment options for Abdel-fattah treatment of locally advanced breast cancer. (who.int)
- 29.1% mandatory part in the treatment of breast cancer respectively, confirmed by national cancer as it provides approximately 70-75% decrease registry program of Egypt. (who.int)
- Patients are taking more proactive roles in treatment decisions and seeking more opinions, not only from doctors but also from friends, family, and other breast cancer survivors. (dovepress.com)
- This is a Phase IV, single-arm, multicenter, open-label clinical trial designed to assess the safety of trastuzumab emtansine in Indian patients with HER2-positive unresectable locally advanced breast cancer (LABC) or metastatic breast cancer (mBC) who have received prior treatment with trastuzumab and a taxane. (centerwatch.com)
- Radiotherapy has become a standard treatment option for a wide range of malignancies. (aacrjournals.org)
Benefit from adjuvant1
- A randomised clinical trial of radiotherapy, chemotherapy (28 day cycles of cyclophosphamide, methotrexate and 5-fluorouracil) or both on women with primary operable breast cancer (n = 322) was followed-up for a median of 27 years. (biomedcentral.com)
- Methods The National Surgical Adjuvant Breast and Bowel Project Protocol B-30 was a randomized trial comparing sequential doxorubicin (A) and cyclophosphamide (C) followed by docetaxel (T) (AC→T), concurrent ACT, or AT in women with node-positive, early-stage breast cancer. (deepdyve.com)
- This was managed with four cycles of neoadjuvant chemotherapy (with adriamycin and cyclophosphamide) followed by breast-conserving surgery and axillary dissection. (mja.com.au)
- As a variation, neoadjuvant chemotherapy is very frequently used for triple-negative breast cancers. (wikipedia.org)
- We evaluated clinical-pathological data from a consecutive series of 150 patients with stage II-IIIC HER2-positive breast cancer treated from August 2004 to December 2012 with trastuzumab-based neoadjuvant chemotherapy. (frontiersin.org)
- Berlin, Germany: The largest study in the world of treatments for post menopausal, hormone positive breast cancer has shown that patients who continue to take exemestane or tamoxifen do significantly better than patients who start to take one or other drug (or tamoxifen followed exemestane) but then stop. (scienceblog.com)
- Professor Cornelis van de Velde, principal investigator at the central data office for TEAM (tamoxifen exemestane adjuvant multinational) trial told Europe's largest cancer congress, ECCO 15 - ESMO 34 , in Berlin today (Tuesday 22 September) that differences in compliance between the nine countries involved in the trial shed light on the role that it played in patient outcome. (scienceblog.com)
- Yet despite this handicap, recurrences of breast cancer in The Netherlands and Belgium were 12% for patients using tamoxifen and 9% of patients using exemestane compared to 8% and 7% internationally. (scienceblog.com)
- We analyzed data for 1,065 estrogen receptor (ER)-positive breast cancer patients who underwent surgery between 2003 and 2006 and received at least 2 years of ET, including tamoxifen and aromatase inhibitors. (biomedcentral.com)
- For the training set, 779 ER-positive breast cancers treated with tamoxifen alone for 5 years were selected from the databases (GSE6532, GSE12093, GSE17705, and GSE26971). (springermedizin.de)
- Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd LE, Pritchard KI et al (2005) Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. (springermedizin.de)
- The use of adjuvant hormone therapy such as tamoxifen has shown to improve local control to a relatively minor amount on its own and does enhance local control of adjuvant radiotherapy. (centerwatch.com)
- Objectives:To prospectively evaluate the lung dose-volume histogram (DVH) data in adjuvant breast RT;deduce the % irradiated volume (PIV) from 2-D parameters and analyze clinical impact with PFT & HRCT. (ersjournals.com)
- PURPOSE: This clinical trial is studying young women's attitudes and feelings about the risk of infertility related to adjuvant therapy for stage I or stage II breast cancer. (clinicaltrials.gov)
- SAFE trial: an ongoing randomized clinical study to assess the role of cardiotoxicity prevention in breast cancer patients treated with anthracyclines with or without trastuzumab. (semanticscholar.org)
- Results of a nationwide survey on Japanese clinical practice in breast-conserving radiotherapy for breast cancer. (bioportfolio.com)
- Older patients with favorable clinical characteristics (earlier stage, smaller tumor, lower grade) are less likely to be treated and have a higher risk of death compared to adjuvant/neoadjuvant treated patients. (scirp.org)
- Recent updates in the American Joint Committee on Cancer Criteria (AJCC) for breast cancer staging manual (8th edition) have incorporated biomarkers and prognostic panel data to guide clinical decision-making. (scirp.org)
- Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. (acc.org)
- Limited data exists demonstrating the clinical benefit of proton radiotherapy (PRT) in breast cancer. (frontiersin.org)
- Locally advanced breast cancer refers to clinical stage 3 disease. (thefreelibrary.com)
- The clinical diagnosis of stage 3 breast cancer is often obvious, but delay in diagnosis may occur in certain cases, for example in inflammatory breast cancer which can mimic cellulitis, and in pregnancy. (thefreelibrary.com)
- These interesting observations will require prospective validation, but the possibility of refining the prognosis of individual patients and influencing clinical decisions regarding the use of adjuvant chemotherapy is an exciting prospect and should be evaluated in well-designed, prospective clinical trials such as the CALGB trial previously mentioned. (amazonaws.com)
- Increasing experimental and clinical evidences demonstrated the synergic effect between the rapidly implemented immunotherapy and advanced forms of focal radiotherapy, not only on the elimination of the irradiated lesion, but also on the enhancement the immune-mediated systemic anti-tumoral activity. (elitmed.hu)
- The researchers concluded that approximately 46% of women with breast cancer who are at high clinical risk might not require chemotherapy. (medscape.com)
- Provides a comprehensive overview of stage 0, I, II and IIIA disease, including the latest thinking on the risk of developing breast cancer and the value (or not) of screening, alongside the importance of clinical staging and triple assessment. (ovid.com)
Cycles of adjuvant chemotherapy1
- The patient received 6 cycles of adjuvant chemotherapy and adjuvant radiotherapy. (hindawi.com)
- There is no consensus regarding adjuvant radiotherapy of periclavicular lymph nodes in patients with limited (1-3) axillary lymph node metastases after breast conserving surgery and axillary dissection. (egms.de)
- Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes. (wikipedia.org)
- Distant metastases are the cause of about 90% of deaths due to breast cancer. (wikipedia.org)
- The symptoms produced by metastatic breast cancer vary by the location of the metastases. (wikipedia.org)
- Roughly 70% of all patients living with advanced breast cancer have bone metastases. (wikipedia.org)
- One-hundred thirty-two patients underwent surgical resection for 141 intracranial metastases: 36 (27 %) patients received adjuvant WBRT and 96 (73 %) received SRS alone to the resection cavity. (springer.com)
- There are at least 16 randomized controlled trials comparing single-fraction vs multifraction radiotherapy in patients with painful bone metastases, so there is level-one evidence to support giving a single fraction in this setting," she explained. (medscape.com)
- Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation surgery? (bmj.com)
- In all, 467 patients including 406 invasive breast cancer and 61 ductal carcinoma in situ ( DCIS ) were enrolled in a single institutional phase II trial. (bvsalud.org)
- Dr. Pollack presents here a large multi-institutional retrospective analysis determining risk factors for outcome with adjuvant and salvage radiotherapy. (oncolink.org)
- Four hundred women having operable breast cancer, treated by adjuvant chemotherapy (CT) and RT in concomitant way between January 2001 and December 2003, were included in this retrospective cohort study. (biomedcentral.com)
- Efficacy analysis of radiotherapy combined with surgery for locally advanced rectal mucinous adenocarcinoma: a retrospective study based on data of Surveillance, Epidemiology, and End results population. (bioportfolio.com)
- Methods: A retrospective observational study in a hospital cohort of 4,413 women diagnosed with breast cancer between 2007-2009, and followed by 60 months. (pulsus.com)
- it was a retrospective chart review of breast cancer patients who refused recommended treatments from 1980 to 2006. (scienceblogs.com)
- It has been proven that adjuvant radiotherapy markedly improves LRC in high risk cases i. (thefreedictionary.com)
- Adjuvant radiotherapy improves lymph node-field control in patients at high risk of relapse after therapeutic lymphadenectomy for metastatic melanoma, an Australian-New Zealand study has confirmed. (amazonaws.com)
- Some types of triple-negative breast cancer are known to be more aggressive with poor prognosis, while other types have very similar or better prognosis than hormone receptor positive breast cancers. (wikipedia.org)
- Mucinous breast cancer generally has a better prognosis (outlook) than most other types of invasive breast cancer. (breastcancercare.org.uk)
- Luminal A breast cancers have better prognosis than other molecular subtypes. (aacrjournals.org)
- Prediction of prognosis by 42GC for recurrent breast cancer patients. (springermedizin.de)
- However, the occurrence of delay in the delivery of adjuvant therapy and its impact on prognosis is not well understood. (springer.com)
Operable breast cancer1
- Our intent-to-treat analysis revealed that single-fraction stereotactic body radiotherapy (SBRT) with either 12 Gy or 16 Gy was not inferior to SMF radiotherapy with regard to pain control and time to local progression," the investigators report. (medscape.com)
- The purpose of this study is to test the safety of giving a few, focused, high doses of radiation (commonly referred to as stereotactic body radiotherapy [SBRT]) to all known sites of cancer within your body. (cityofhope.org)
- For very large tumours or in the rare case of inflammatory breast cancer, a course of medication may be necessary before the first operation, to reduce the size of the tumour before the surgery can go ahead. (pyramide.ch)
- Certain tumours may be suitable for breast-conserving surgery after chemotherapy. (thefreelibrary.com)
- Neoadjuvant chemo-radiotherapy is utilized for locally advanced rectal cancer to optimize local control. (bioportfolio.com)
- To explore the efficacy of radiotherapy combined with surgery for locally advanced rectal mucinous adenocarcinoma. (bioportfolio.com)
- Locally advanced rectal cancer: qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging in restaging after neoadjuvant chemo-radiotherapy. (bioportfolio.com)
- Locally advanced breast cancer is cancer that has spread beyond the breast to the chest wall or the skin on top of the breast. (breastcancer.org)
- The researchers looked at the results of three small studies evaluating giving both chemotherapy and radiation before surgery in 105 women diagnosed with locally advanced breast cancer. (breastcancer.org)
- Patients with ER-positive, HER2-negative locally advanced breast cancer (LABC) are unlikely to achieve a pCR from currently available chemotherapy. (medscape.com)
- The patient had been diagnosed with locally advanced breast cancer 3 years earlier. (mja.com.au)
Intensity Modulated Radiotherapy2
Therapy for breast cancer2
- That makes this study one of the uncommon studies that really look at what happens when women refuse all standard therapy for breast cancer. (scienceblogs.com)
- Adjuvant therapy for breast cancer is designed to treat micrometastatic disease, or breast cancer cells that have escaped the breast and regional lymph nodes but have not yet established an identifiable metastasis. (medscape.com)
- The 21-gene RS for elderly (≥65 years) women with stage T1-2N0M0 estrogen receptor-positive breast cancer who underwent BCS from 2004 to 2015 was obtained from the Surveillance, Epidemiology, and End Results program. (cdc.gov)
- Patients were diagnosed with stage I-III disease between 1/1/2007-12/31/2011, ≥66 years, enrolled in Medicare Parts A, B and D, and underwent breast cancer surgery after diagnosis. (scirp.org)
- Using our institution's prospectively maintained web-based database, we identified a total of 1,542 ER-positive breast cancer patients who underwent curative surgery at Seoul National University Hospital between October 2003 and December 2006. (biomedcentral.com)
- whose primary tumour is larger than 5 cm and/or dividing subjects into 2 arms, one group patients who have four or more involved axillary underwent conventional radiotherapy and other lymph nodes (ALNs). (who.int)
Response to radiotherapy1
- abstract = "PurposeTo evaluate the use of exercise in managing fatigue in breast cancer patients undergoing adjuvant radiotherapy. (ulster.ac.uk)
- It may involve placing radioactive sources into the surgery site after removing a breast lump lumpectomy . (medlineplus.gov)
- Permanent breast seed implant (PBSI), in which radioactive seeds are individually inserted through a needle into the breast cavity several weeks after lumpectomy. (medlineplus.gov)
- Lumpectomy patients must then undergo radiotherapy. (knowcancer.com)
- Permanent breast seed implant (PBSI), which is placed through the skin several weeks after lumpectomy. (limamemorial.org)
Sentinel lymph node2
- Sentinel lymph node biopsy is widely used for people with breast cancer whose tests before surgery show no evidence of the lymph nodes containing cancer cells. (breastcancercare.org.uk)
- Find out more information about breast surgery, including lymph node removal and sentinel lymph node biopsy. (breastcancercare.org.uk)
- It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer or, rarely, before the primary breast cancer has been diagnosed. (wikipedia.org)
- Metastatic breast cancer cells frequently differ from the preceding primary breast cancer in properties such as receptor status. (wikipedia.org)
- Adjuvants are drugs whose primary indication is not analgesia, but when used in specific pain situations may be effective as analgesics or co-analgesics. (caresearch.com.au)
- This is known as neo-adjuvant or primary therapy. (breastcancercare.org.uk)
- Adjuvant radiotherapy is well established as the primary modality to enhance local control in breast cancer. (centerwatch.com)
- The primary objective of the proposed research is to provide the first data on the role of CNS glutamate and symptoms of fatigue in breast cancer patients using MRS and a medication that has been shown to lower CNS glutamate in animal models and human subjects. (centerwatch.com)
- There is no cure for metastatic breast cancer. (wikipedia.org)
- Metastatic breast cancer can be treated, sometimes for many years, but it cannot be cured. (wikipedia.org)
- Metastatic disease to the liver causes jaundice, elevated liver enzymes, abdominal pain, loss of appetite, nausea, and vomiting Metastatic breast cancer to the lung or pleura causes chronic cough, dyspnea, abnormal chest X-ray, and chest pain. (wikipedia.org)
- Other nonspecific systemic symptoms of metastatic breast cancer include fatigue, malaise, weight loss, and poor appetite. (wikipedia.org)
- Patients with non-metastatic breast cancer treated with adjuvant radiotherapy from 2004 to 2014 were identified. (frontiersin.org)
- A biopsy of the lung lesion confirmed the presence of adenocarcinoma consistent with metastatic breast cancer. (mja.com.au)
- In this analysis outcome of breast cancer patients with limited axillary lymph node involvement was independent of PLNI. (egms.de)
- The aim the present study was therefore to establish long term outcome in women receiving adjuvant radiotherapy and chemotherapy as part of a randomised trial. (biomedcentral.com)
- Immediate or delayed reconstruction can be considered, although the cosmetic outcome may be affected by radiotherapy. (thefreelibrary.com)
Cancer is the commonest2
- Breast-conserving surgery necessarily includes local radiotherapy of the residual mammary gland and possibly the lymph drainage system, depending on how far the tumour has spread. (pyramide.ch)
- Breast cancer can metastasize anywhere in body but primarily metastasizes to the bone, lungs, regional lymph nodes, liver and brain, with the most common site being the bone. (wikipedia.org)
- However, radiotherapy is not combined with lymph node clearance. (healthhype.com)
- Your specialist team will also want to check whether breast cancer cells have spread from the breast to the lymph nodes (glands) under the arm (the axilla). (breastcancercare.org.uk)
- Because it's less common for mucinous breast cancer to have spread to the lymph nodes under the arm, and it's more likely to grow more slowly than other types of breast cancer, chemotherapy is not often used. (breastcancercare.org.uk)
- removal of some or all of the lymph nodes from the armpit to see if the breast cancer has spread beyond the breast. (bcna.org.au)
- Early breast cancer patients,treated adjuvantly with radiotherapy of the operated breast or thoracic wall and treated concomitantly with trastuzumab. (clinicaltrials.gov)
- Three recent studies suggest that cardiac mortality has not been greater for patients treated for left-sided breast cancer since the 1980s, when techniques allowing for greater cardiac avoidance became more commonplace[1- (eurekalert.org)
- There were 13,670 (74%) patients treated with adjuvant/neoadjuvant therapy and 4800 (26%) untreated. (scirp.org)