Breast Neoplasms: Tumors or cancer of the human BREAST.Inflammatory Breast Neoplasms: Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.Triple Negative Breast Neoplasms: Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Breast Neoplasms, Male: Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Breast Diseases: Pathological processes of the BREAST.Breast Feeding: The nursing of an infant at the breast.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Mammography: Radiographic examination of the breast.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Cell Line, Tumor: A cell line derived from cultured tumor cells.Fibrocystic Breast Disease: A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Breast Self-Examination: The inspection of one's breasts, usually for signs of disease, especially neoplastic disease.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Skin Neoplasms: Tumors or cancer of the SKIN.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.DNA, Neoplasm: DNA present in neoplastic tissue.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Mastectomy: Surgical procedure to remove one or both breasts.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Lung Neoplasms: Tumors or cancer of the LUNG.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Ultrasonography, Mammary: Use of ultrasound for imaging the breast. The most frequent application is the diagnosis of neoplasms of the female breast.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Genes, BRCA1: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Liver Neoplasms: Tumors or cancer of the LIVER.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Postmenopause: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.Fibroadenoma: An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Mastectomy, Segmental: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.Milk, HumanCystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Mammaplasty: Surgical reconstruction of the breast including both augmentation and reduction.Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Breast Cyst: A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Nipples: The conic organs which usually give outlet to milk from the mammary glands.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Estrogen Receptor alpha: One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.MCF-7 Cells: An estrogen responsive cell line derived from a patient with metastatic human breast ADENOCARCINOMA (at the Michigan Cancer Foundation.)Mammary Glands, Human: Glandular tissue in the BREAST of human that is under the influence of hormones such as ESTROGENS; PROGESTINS; and PROLACTIN. In WOMEN, after PARTURITION, the mammary glands secrete milk (MILK, HUMAN) for the nourishment of the young.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Premenopause: The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Eye Neoplasms: Tumors or cancer of the EYE.Uterine Neoplasms: Tumors or cancer of the UTERUS.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Axilla: Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.Neoplasms, Hormone-Dependent: Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.Breast Implantation: Surgical insertion of an inert sac filled with silicone or other material to augment the female form cosmetically.Nose Neoplasms: Tumors or cancer of the NOSE.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.BRCA2 Protein: A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)Colonic Neoplasms: Tumors or cancer of the COLON.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.BRCA1 Protein: The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)RNA, Neoplasm: RNA present in neoplastic tissue.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Neoplasms, Muscle Tissue: Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Adenoma: A benign epithelial tumor with a glandular organization.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Genes, BRCA2: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)Sweat Gland NeoplasmsRNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Neoplasms, Adnexal and Skin Appendage: Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.Genes, erbB-2: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.Vascular Neoplasms: Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Neoplasms, Complex and Mixed: Neoplasms composed of more than one type of neoplastic tissue.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Aromatase Inhibitors: Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.Estrogen Antagonists: Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Palatal Neoplasms: Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Mandibular Neoplasms: Tumors or cancer of the MANDIBLE.Adenofibroma: A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)Thymus Neoplasms: Tumors or cancer of the THYMUS GLAND.Splenic Neoplasms: Tumors or cancer of the SPLEEN.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Heart Neoplasms: Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.Cystadenoma, Serous: A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Maxillary Neoplasms: Cancer or tumors of the MAXILLA or upper jaw.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Hemangiosarcoma: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)Anal Gland Neoplasms: Tumors or cancer of the anal gland.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Stomach Neoplasms: Tumors or cancer of the STOMACH.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Neoplasms, Adipose Tissue: Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.Germ-Line Mutation: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Mouth Neoplasms: Tumors or cancer of the MOUTH.Biopsy, Fine-Needle: Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Mediastinal Neoplasms: Tumors or cancer of the MEDIASTINUM.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Transplantation, Heterologous: Transplantation between animals of different species.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Selective Estrogen Receptor Modulators: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)Janus Kinase 2: A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (1/361)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer.  (+info)

Androgen receptor expression in male breast carcinoma: lack of clinicopathological association. (2/361)

Androgen receptor (AR) expression was retrospectively analysed in 47 primary male breast carcinomas (MBCs) using a monoclonal antibody on formalin-fixed, paraffin-embedded tissues. AR immunopositivity was detected in 16 out of 47 (34%) cases. No association was found with patient age, tumour stage, progesterone receptor (PGR) or p53 protein expression. Well-differentiated MBCs tended to be AR positive more often than poorly differentiated ones (P = 0.08). A negative association was found between ARs and cell proliferative activity: MIB-1 scores were higher (25.4%) in AR-negative than in AR-positive cases (21.11%; P = 0.04). A strong positive association (P = 0.0001) was found between ARs and oestrogen receptors (ERs). In univariate analysis, ARs (as well as ERs and PGRs) were not correlated with overall survival; tumour histological grade (P = 0.02), size (P = 0.01), p53 expression (P = 0.0008) and MIB-1 scores (P = 0.0003) had strong prognostic value. In multivariate survival analysis, only p53 expression (P = 0.002) and histological grade (P = 0.02) retained independent prognostic significance. In conclusion, the lack of association between AR and most clinicopathological features and survival, together with the absence of prognostic value for ER/PGR status, suggest that MBCs are biologically different from female breast carcinomas and make it questionable to use antihormonal therapy for patients with MBC.  (+info)

High frequency of germ-line BRCA2 mutations among Hungarian male breast cancer patients without family history. (3/361)

To determine the contribution of BRCA1 and BRCA2 mutations to the pathogenesis of male breast cancer in Hungary, the country with the highest male breast cancer mortality rates in continental Europe, a series of 18 male breast cancer patients and three patients with gynecomastia was analyzed for germ-line mutations in both BRCA1 and BRCA2. Although no germ-line BRCA1 mutation was observed, 6 of the 18 male breast cancer cases (33%) carried truncating mutations in the BRCA2 gene. Unexpectedly, none of them reported a family history for breast/ovarian cancer. Four of six truncating mutations were novel, and two mutations were recurrent. Four patients (22%) had a family history of breast/ovarian cancer in at least one first- or second-degree relative; however, no BRCA2 mutation was identified among them. No mutation was identified in either of the genes in the gynecomastias. These results provide evidence for a strong genetic component of male breast cancer in Hungary.  (+info)

Breast cancer risk in ataxia telangiectasia (AT) heterozygotes: haplotype study in French AT families. (4/361)

Epidemiological studies in ataxia telangiectasia (AT) families have suggested that AT heterozygotes could have an increased cancer risk, especially breast cancer (BC) in women. It has also been suggested that an increased sensibility of AT heterozygotes to the effect of ionizing radiation could be responsible for the increased BC risk. BC relative risk (RR) estimation in AT heterozygotes within families ascertained through AT children is presented here. Family data collected included demographic characteristics, occurrence of cancers, past radiation exposures and blood samples. DNA samples were studied using seven ATM linked microsatellites markers allowing AT haplotypes reconstitution. The relative risk of BC was assessed using French estimated incidence rates. A significant increase risk of BC is found among obligate ATM heterozygotes with a point estimate of 3.32 (P = 0.002). BC relative risk calculated according to age is significantly increased among the obligate ATM heterozygotes female relatives with an age < or = 44 years (RR = 4.55, P = 0.005). The BC relative risk is statistically borderline among the obligate ATM heterozygote female relatives with an age > or = 45 years (RR = 2.48, P = 0.08). The estimated BC relative risk among ATM heterozygotes is consistent with previously published data. However, the increased risk is only a little higher than classical reproductive risk factors and similar to the risk associated with a first-degree relative affected by BC.  (+info)

Autotransplants in men with breast cancer. ABMTR Breast Cancer Working Committee. Autologous Blood and Marrow Transplant Registry. (5/361)

The purpose of this study was to determine the outcome of high-dose therapy with autologous hematopoietic stem cell support (autotransplants) in men with breast cancer. We studied 13 men receiving autotransplants for breast cancer and reported to the Autologous Blood and Marrow Transplant Registry (ABMTR) by 10 centers. Six men had stage 2 breast cancer, four had stage 3, and three had metastatic breast cancer. Of twelve tumors tested, all were estrogen receptor positive. Median age at transplant was 50 years. The most common conditioning regimen was cyclophosphamide, thiotepa and carboplatin (n = 5); the remaining eight men received other alkylator-based regimens. Three men received bone marrow, eight received blood stem cells, and two received both for hematopoietic support. All patients had hematopoietic recovery. There were no unexpected regimen-related toxicities. Of 10 men receiving autotransplants as adjuvant therapy, three relapsed 3, 5 and 50 months post-transplant and died 16, 19 and 67 months post-transplant. Seven of 10 are disease-free with median follow-up of 23 months (range 6-50 months). Of three men treated for metastatic breast cancer, one had progressive disease and two recurrent disease at 6, 7 and 16 months post-transplant. In conclusion, results of autotransplants for male breast cancer appear similar to those reported for women receiving autotransplants for breast cancer.  (+info)

A polymorphism in the CYP17 gene is associated with male breast cancer. (6/361)

The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.  (+info)

A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant. (7/361)

High-dose chemotherapy (HDCT) is currently under evaluation for high-risk primary breast cancer (HRPBC), defined by extensive axillary nodal involvement or inflammatory breast carcinoma. Phase II studies of HDCT for HRPBC show that 30-40% of patients eventually relapse. We retrospectively reviewed 176 patients enrolled in clinical trials of HDCT for HRPBC at the University of Colorado and analyzed 23 potential predictive variables for relapse. All of the patients received the same regimen, with cyclophosphamide, cisplatin, and BCNU. Nine patients who experienced a toxic death were excluded from this analysis. The resulting predictive model was subsequently tested in an independent patient set treated at Duke University with the same HDCT regimen. Nodal ratio (number of involved nodes:number of sampled nodes), tumor size, grade, stage, estrogen receptor, progesterone receptor, and clinical inflammatory breast carcinoma correlated with risk of relapse. Nodal ratio, tumor size, and the combined estrogen receptor/progesterone receptor status were independent predictors. A scoring system using those three variables determines the risk of relapse, with a sensitivity and specificity of 60 and 90%, respectively, and a positive and negative predictive value of 65 and 88%, respectively. The differences in relapse-free survival and overall survival between high- and low-score patients were highly significant (P<0.000001). This model was subsequently validated in the Duke patient set. This model can identify two subgroups of HRPBC patients with low (12%) and high (65%) risk for recurrence after HDCT. Future research that tests new therapies will focus on those patients with a high score.  (+info)

Risk estimation as a decision-making tool for genetic analysis of the breast cancer susceptibility genes. EC Demonstration Project on Familial Breast Cancer. (8/361)

For genetic counselling of a woman on familial breast cancer, an accurate evaluation of the probability that she carries a germ-line mutation is needed to assist in making decisions about genetic-testing. We used data from eight collaborating centres comprising 618 families (346 breast cancer only, 239 breast or ovarian cancer) recruited as research families or counselled for familial breast cancer, representing a broad range of family structures. Screening was performed in affected women from 618 families for germ-line mutations in BRCA1 and in 176 families for BRCA2 mutations, using different methods including SSCP, CSGE, DGGE, FAMA and PTT analysis followed by direct sequencing. Germ-line BRCA1 mutations were detected in 132 families and BRCA2 mutations in 16 families. The probability of being a carrier of a dominant breast cancer gene was calculated for the screened individual under the established genetic model for breast cancer susceptibility, first, with parameters for age-specific penetrances for breast cancer only [7] and, second, with age-specific penetrances for ovarian cancer in addition [20]. Our results indicate that the estimated probability of carrying a dominant breast cancer gene gives a direct measure of the likelihood of detecting mutations in BRCA1 and BRCA2. For breast/ovarian cancer families, the genetic model according to Narod et al. [20] is preferable for calculating the proband's genetic risk, and gives detection rates that indicate a 50% sensitivity of the gene test. Due to the incomplete BRCA2 screening of the families, we cannot yet draw any conclusions with respect to the breast cancer only families.  (+info)

TY - JOUR. T1 - Lymphatic mapping for male breast cancer. AU - Albo, Daniel. AU - Ames, F. C.. AU - Hunt, K. K.. AU - Ross, M. I.. AU - Singletary, S. E.. AU - Kuerer, H. M.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - OBJECTIVE: Sentinel lymph node biopsy (SLNB) is emerging as an alternative to axillary lymph node dissection (ALND) for many female breast cancer patients. In contrast, ALND remains the standard of care tor male breast patients with similar tumors. We evaluated the results of SLNB in male breast cancer patients with clinically negative axillas. METHODS: The patient population consisted of six consecutive male breast cancer patients, ages 44 to 76 years old, treated at our institution. All patients had negative axillas by clinical exam and ultrasound. Preoperative lymphoscintigraphy was used in all cases. In each patient, 5 cc of isosulfan blue 1% was injected intraoperatively adjacent to the breast tumor or biopsy cavity prior to SLNB. Additionally, Tc-99m sulfur colloid was injected at ...
Breast cancer in men is a rare disease with approximately 0.5- 1% of all breast cancer cases. Each year, about 400 to 450 cases are diagnosed in Germany. Men tend to present with more advanced disease than women, probably due to the lack of awareness of male breast cancer from both, the patient and the physicians.. Therefore, at presentation they usually have lump or nipple inversion, and more than 40% of the patients have a stage III or IV disease. The great majority of patients have an invasive ductal (90%), hormone receptor positive (90%), HER2 negative (90%) tumor.. The only available information on adjuvant therapies derives from few retrospective cases and retrospective studies with a little number of cases. Therefore, treatment strategies are not based on data from prospective, randomised clinical studies, and optimal treatment is unknown. As a result, current clinical management is generally extrapolated from principles established for the treatment of female breast carcinoma. As the ...
In men with node-negative tumors, adjuvant therapy should be considered on the same basis as for women with breast cancer because there is no evidence that response to therapy is different between men and women. [11]. In men with node-positive tumors, both chemotherapy plus tamoxifen and other hormonal therapy have been used and are believed to increase survival to the same extent as in women with breast cancer.. Approximately 85% of all male breast cancers are estrogen receptor-positive, and 70% of them are progesterone receptor-positive. [2] [12] Response to hormone therapy correlates with the presence of these receptors. Hormonal therapy has been recommended in all patients with receptor-positive cancers. [1] [2] Tamoxifen use, however, is associated with a high rate of treatment-limiting symptoms, such as hot flashes and impotence, in male breast cancer patients. [13] Responses are generally similar to those seen in women with breast cancer. [2] (Refer to Postoperative Systemic Therapy and ...
Male Breast Cancer, Read about Male Breast Cancer symptoms, causes, diagnosis, and treatment. Also read Male Breast Cancer articles about how to live with Male Breast Cancer, and more.
The aim of this thesis was to investigate the prognostic role of the proliferation markers cyclin B1 and Phosphorylated Histone 3 (PPH3) in breast cancer (BC).. In paper I we used an experimental study design, we compared women dying early from their BC with women free from relapse more than eight years after initial diagnosis. All women had stage I, node-negative and hormone receptor positive disease. None had received adjuvant chemotherapy. We found that low-risk node negative patients with high expression of cyclin B1 had a significantly worse outcome than patients with low expression of cyclin B1.. In paper II a population-based case control study was performed to further investigate the prognostic value of cyclin B1. One hundred and ninety women who died from BC were defined as cases and 190 women alive at the time for the corresponding cases death were defined as controls. Inclusion criteria were tumor size 50 mm, no lymph node metastases, and no adjuvant chemotherapy. Two investigators ...
Sprouted San Diego-CA. Interpellated through Midwest universities. Working the borderline South. Dialogic Cinephilia is the belief that in order to better understand/appreciate the world of cinema, one must learn about the world. This website is an ongoing document of the cultural derive (wanderings) of a Humanities professor and a series of ongoing archives for retracing my steps when needed. Trigger Warning: You may be introduced to concepts and ideas that may conflict with your worldview. Please remain calm, you are not required to adopt these ideas and/or integrate them into your lifestyle. All we are asking is that you consider how other people/cultures think/believe/live. Think, share and live fully - stay awake, stay wild, inspire others! Feel free to say hi, provide comments, concerns, or suggestions, in the comments section on the posts ...
Breast cancer represents less than 1% of all cancers in men1; the male to female ratio is 1:100.2 Since 1973 there has been a gradual increase in the incidence of male breast cancer, the reasons for which are unclear. Nonetheless the overall incidence remains low, at about 1 case per 100,000 population per year.3 Unlike women, where breast cancer displays a bimodal distribution, the disease in men increases exponentially with age. The median age at presentation for male breast cancer is 65 to 71, unlike with women, in whom breast cancer is seen about 5 to 10 years earlier.4 The epidemiology of breast cancer in men is similar to that in women, such that North America and Europe see the highest incidences, while Japan has the lowest.5 Interestingly, in sub-Saharan countries in Africa where infectious liver damage is common, such as in Zambia6 and Uganda,7 7% to 14% of breast cancer cases occur in men. In the United States, tumor registries indicate that male breast cancer is most common in African ...
Radiation exposure is a known risk factor for many cancers, including breast cancer. Repeated or lengthy exposure to diagnostic radiographs or radiation therapy increases the risk of male breast cancer (24). A recent paper (25) which examined male incidence and mortality of breast cancer in atomic bomb survivors found a much higher radiation-associated relative risk for male than for female breast cancer.. There is increasing evidence that male breast cancer is associated with exposure to environmental pollutants, including carcinogens and endocrine disrupting chemicals (EDCs), especially oestrogen mimicking chemicals (26), which induce similar actions to those of oestrogen and have been linked to increased breast cancer risk and other health problems, including prostate cancer. For further details about EDCs and breast cancer risk read our Background Briefing on endocrine disrupting chemicals.. Certain occupations may also carry a higher risk of breast cancer. For example, motor vehicle ...
Do You Have Male Breast Neoplasms? Join friendly people sharing true stories in the I Have Male Breast Neoplasms group. Find forums, advice and chat with groups who share this life experience. Male Breast Neoplasms anonymous support group with inform...
TY - JOUR. T1 - The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer. AU - Di Benedetto, Anna. AU - Mottolese, Marcella. AU - Sperati, Francesca. AU - Ercolani, Cristiana. AU - Di Lauro, Luigi. AU - Pizzuti, Laura. AU - Vici, Patrizia. AU - Terrenato, Irene. AU - Sperduti, Isabella. AU - Shaaban, Abeer M. AU - Sundara-Rajan, Sreekumar. AU - Barba, Maddalena. AU - Speirs, Valerie. AU - De Maria, Ruggero. AU - Maugeri-Saccà, Marcello. N1 - This study was supported by the "Associazione Italiana per la Ricerca sul Cancro" (AIRC IG Grant N:13431 to RDM), and by Breast Cancer Now (formerly Breast Cancer Campaign; grant 2007MayPR02 to VS and AMS), which provided funding for the accrual and construction of the MBC TMAs described.. PY - 2016/7/12. Y1 - 2016/7/12. N2 - Male breast cancer (MBC) is a rare disease and its biology is poorly understood. Deregulated Hippo pathway promotes oncogenic functions in female breast cancer. We herein investigated the expression of the Hippo ...
According to Cancer Research UK, a cell needs to have a number of mistakes in its genetic code before it becomes cancerous. Between 45 and 90 out of every 100 women carrying BRCA genes will get breast cancer at some point in their lives. Lifetime risk can be quite difficult to understand. 1 in 8 women in the UK will develop breast cancer during their lifetime. In men, breast cancer is very rare. The same treatments are used for breast cancer in men as for women. As with women, the single biggest risk factor for male breast cancer is getting older. Most cases are diagnosed in men between the ages of 60 and 70. There are significant differences between male and female breast cancer: almost half of male breast cancer patients are stage III or IV. Iron is essential for an array of key biological processes including erythrocyte production, DNA synthesis and cellular respiration. Women are not able to store iron as efficiently as men. Iron deficiency anemia can cause headaches, moodiness, tiredness, ...
Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. Breast cancer may occur in men. Men at any age may develop breast cancer, but it is usually detected (found) in men between 60 and 70 years of age. Male breast cancer makes up less than 1% of all cases of breast cancer...
TY - JOUR. T1 - Is Breast Conserving Therapy a Safe Modality for Early-Stage Male Breast Cancer?. AU - Zaenger, David. AU - Rabatic, Bryan M.. AU - Dasher, Byron. AU - Mourad, Waleed F.. PY - 2016/4/1. Y1 - 2016/4/1. N2 - Introduction Male breast cancer (MBC) is a rare disease and lacks data-based treatment guidelines. Most men are currently treated with modified radical mastectomy (MRM) or simple mastectomy (SM). We compared the oncologic treatment outcomes of early-stage MBC to determine whether breast conservation therapy (BCT) is appropriate. Materials and Methods We searched the Surveillance, Epidemiology, and End Results database for MBC cases. That cohort was narrowed to cases of stage I-II, T1-T2N0 MBC with surgical and radiation therapy (RT) data available. The patients had undergone MRM, SM, or breast conservation surgery (BCS) with or without postoperative RT. We calculated the actuarial 5-year cause-specific survival (CSS). Results We identified 6263 MBC cases and included 1777 men ...
Description on Male Breast cancer along with its causes and various risk factors given. Mammography along with careful examination might be useful as a screening examination for men with a strong family history and BRCA mutations. Breast cancer in men with its various diagnosis methods and tests also included.
Objective-To investigate whether risk of male breast cancer is associated with workplace exposures. Methods-A case-control study of 178 cases of male breast cancer and 1041 controls was carried out with data from the United States national mortality follow-back survey, which collected questionnaire information from proxy respondents of a 1%...
Propecia May Cause Male Breast Cancer. If you took Finasteride and were diagnosed with male breast cancer, this drug may be to blame.
Male breast cancer (male breast neoplasm) is a rare cancer in males that originates from the breast. Many males with breast cancer have inherited a BRCA mutation, but there are other causes, including alcohol abuse and exposure to certain hormones and ionizing radiation. As it presents a similar pathology as female breast cancer, assessment and treatment relies on experiences and guidelines that have been developed in female patients. The optimal treatment is currently not known. As in females, infiltrating ductal carcinoma is the most common type. While intraductal cancer, inflammatory carcinoma, and Pagets disease of the nipple have been described, lobular carcinoma in situ has not been seen in males. Breast cancer in males spreads via lymphatics and blood stream like female breast cancer. Accordingly, the TNM staging system for breast cancer is the same for males and females. Size of the lesion and lymph node involvement determine prognosis; thus small lesions without lymph node involvement ...
Looking for Male Breasts? Find out information about Male Breasts. see mammary gland mammary gland, organ of the female mammal that produces and secretes milk for the nourishment of the young. A mammal may have from 1 to 11... Explanation of Male Breasts
Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biological and molecular differences likely to impact on tumour behaviour and therefore patient outcome. The aim of this study was to investigate methylation of a panel of commonly methylated breast cancer genes in familial MBCs. 60 tumours from 3 BRCA1 and 25 BRCA2 male mutation carriers and 32 males from BRCAX families were assessed for promoter methylation by methylation-sensitive high resolution melting in a panel of 10 genes (RASSF1A, TWIST1, APC, WIF1, MAL, RARβ, CDH1, RUNX3, FOXC1 and GSTP1). An average methylation index (AMI) was calculated for each case comprising the average of the methylation of the 10 genes tested as an indicator of overall tumour promoter region methylation. Promoter hypermethylation and AMI were correlated with BRCA carrier mutation status and clinicopathological
Male breast cancer is an uncommon variant of breast cancer with an increasing incidence. Knowledge of breast cancer in men has traditionally been …
The objective of this study is to investigate the potential association between finasteride (MK-0906) exposure and the development of breast cancer in men residing in Denmark, Sweden, Finland, and Norway from data in national registries. The primary hypothesis of this study is that the previously reported increased incidence of male breast cancer among finasteride users is explained by confounding factors ...
Male breast cancer accounts for 1% of all breast cancers worldwide. It can be diagnosed through self-exams, blood tests, biopsies, an ultrasound exam, and MRI.
Male breast cancer treatment options mirror the ones that women who have breast cancer have available to them. Click to read more about TGHs approach.
The role of occupational exposure to heat and electromagnetic fields was investigated in a case-control study of male breast cancer. Seventy-one cases reported to the New York State Tumor Registry between 1979 and 1988 were compared with 256 healthy male controls. Controls were frequency matched to cases by race, year of diagnosis, and age in 5-...
Misdiagnosis of Male Breast Cancer including hidden diseases, diagnosis mistakes, alternative diagnoses, differential diagnoses, and misdiagnosis.
Male Breast Surgery & Complications, The Cost of Male Breast Implants, Surgery Information. Your implant could become displaced or shift a bit. infection.
Lymph node involvement and the pattern of cancer spread are similar to those found in female breast cancer. The staging system for male breast cancer is identical to the staging system for female breast cancer.. Prognostic factors that have been evaluated include the size of lesion and the presence or absence of lymph node involvement, both of which influence treatment outcomes.. Overall survival for men with breast cancer is similar to that of women with breast cancer. The impression that male breast cancer has a worse prognosis may be due to the fact that it tends to be diagnosed at a later stage.. ...
Lymph node involvement and the pattern of cancer spread are similar to those found in female breast cancer. The staging system for male breast cancer is identical to the staging system for female breast cancer.. Prognostic factors that have been evaluated include the size of lesion and the presence or absence of lymph node involvement, both of which influence treatment outcomes.. Overall survival for men with breast cancer is similar to that of women with breast cancer. The impression that male breast cancer has a worse prognosis may be due to the fact that it tends to be diagnosed at a later stage.. ...
Breast Cancer 2020 is taking place on April 20-21, 2020, Berlin, Germany. Breast Cancer Conference is conducting on the theme of Determining the possible ways to cure and prevent breast cancer. Breast Cancer Conference is a unique conference which is going to make the differences in Breast Cancer Diagnosis
It happens to one in every 1,000 men.. Those arent high odds, but the diagnosis can still be devastating. One of every 1,000 men will develop breast cancer in his lifetime, and the chances of making a full recovery rest in large part in how quickly the cancer is discovered and how soon appropriate treatment is begun.. Male or female, everyone begins his or her life with a small amount of breast tissue, consisting of milk-producing glands, ducts that carry milk to the nipples, and fat. But during puberty, women develop additional breast tissue, while men do not. Still, that breast tissue is present for life.. Not surprisingly, most men dont dwell on the thought that they could develop breast cancer. But it can happen. And experts say that because men dont anticipate getting breast cancer, they may be less aware of the signs and symptoms that women are educated to be familiar with all their lives.. Just recently, a local man was referred to us for mammogram screening by his physician. As many ...
Former Sen Edward W Brooke speaks publicly for first time about being diagnosed with breast cancer, hoping to bring attention to disease that many men assume they cannot get; breast cancer in men is rare, but higher percentage of men than women die of disease because it is typically detected at much later stage; cancer researchers estimate that roughly 400 of 1,500 men diagnosed with breast cancer this year will eventually die of it, while 40,000 of approximately 211,000 women with new cases of breast cancer will die; Brooke, like most men with the disease, says he shrugged off early warning signs and waited several months before consulting physician; says after mammogram, sonogram and tissue biopsy he received staggering diagnosis, and underwent double mastectomy shortly thereafter; encourages men to perform self-examination; photo (M)
About 10 percent of men diagnosed with breast cancer have a breast cancer-related genetic mutation, most commonly in the BRCA1 or BRCA
To test the hypothesis that in utero exposure to high levels of oestrogen increases the risk of male breast cancer, we followed 115 235 male twins for more than 3.5 million person-years at risk. We observed 11 cases of male breast cancer versus 16.16 expected based on national rates (standardized rate ratio 0.68, 95% confidence interval 0.34-1.22) and conclude that any adverse influence of in utero oestrogen exposure is likely to be small.
When men do think about breast cancer, its usually their wives, daughters or mothers that come to mind. Breast cancer is simply seen as a womans disease - and some men dont even realize that this form of cancer can happen to them. But although it …. ...
Breast cancer is thought of as a womens disease, with less than 1 percent of breast cancers affecting men, according to breastcancer.org. Because of that, there is a lack of awareness about the disease in males, which leads to late diagnoses and lower cha
Breast cancer is thought of as a womens disease, with less than 1 percent of breast cancers affecting men, according to breastcancer.org. Because of that, there is a lack of awareness about the disease in males, which leads to late diagnoses and lower cha
Breast cancer is thought of as a womens disease, with less than 1 percent of breast cancers affecting men, according to breastcancer.org. Because of that, there is a lack of awareness about the disease in males, which leads to late diagnoses and lower cha
October is Breast Cancer Awareness Month. Numerous stories on the subject mostly focus on women. Men also get breast cancer, but their lack of awareness
Side effects for men with breast cancer taking Tamoxifen include headaches, nausea, hot flashes, skin rash, fatigue, sexual dysfunction, and weight and mood changes.
Men can develop breast cancer with symptoms similar to those that women experience. Contact Tampa General Hospital to learn more.
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Male breast cancer accounts for less than 1% of all breast cancers according to a study in 2003 by Weir et al. However, the time from onset of symptoms to diagnosis in men is longer than in women (approximately 22 months), and as a result, men often present with later-stage disease, most likely due to a lack of awareness that men can develop breast cancer. Genetically, while male BRCA1 mutation carriers have approximately a 1.2% risk of developing breast cancer, male BRCA2 mutation carriers have a 6.3% lifetime absolute risk of breast cancer. This is a 100-fold higher risk than exists in the general male population. In their article, Lucy R. Kahn, BSc (Hons) MB ChB MRCSEd, and J. Michael Dixon, BSc (Hons) MB ChB MD FRCS FRCSEd, discuss the case of a 43-year old man who presented in 2002 with a painless breast lump and a strong family history of breast cancer. The patient underwent surgery and endocrine therapy, followed by a regimen of 4 cycles of epirubicin and 8 cycles of cyclophosphamide plus ...
Cancer is not usually inherited, but some types - mainly breast, ovarian, colorectal and prostate cancer - can be strongly influenced by genes and can run in families.. We all carry certain genes that are normally protective against cancer. These genes correct any DNA damage that naturally happens when cells divide.. Inheriting faulty versions or variants of these genes significantly raises your risk of developing cancer, because the altered genes cannot repair the damaged cells, which can build up and form a tumour.. BRCA1 and BRCA2 are two examples of genes that raise your cancer risk if they become altered. Having a variant BRCA gene greatly increases a womans chance of developing breast cancer and ovarian cancer. This was the reason Angelina Jolie had preventative breast cancer surgery, followed by ovarian cancer surgery. They also increase a mans chance of developing male breast cancer and prostate cancer. BRCA genes are not the only cancer risk genes. Researchers recently identified ...
Introduction Previous studies showed that TNM stages that were clinically determined before surgery were not often concordant with pathological TNM stages. However, no previous studies have examined variations of discordance of the clinical TNM stage with the pathological TNM stage among hospitals. We aimed to examine the discordance of the clinical and pathological stages among Japanese designated cancer hospitals using compiled data from the hospital-based cancer registry submitted from 286 designated cancer care hospitals in Japan.. Methods The registry data had UICC TNM stages before and after surgery for stomach, colorectal, lung and breast cancer patients treated in these hospitals. We excluded patients who received adjuvant chemotherapy or radiotherapy, patients who received care from facilities with less than 10 patients, male breast cancer and patients whose stages were unknown from the analysis. We also calculated discordance of stages that could have theoretically resulted in changes ...
Its estimated 480 men will die of male breast cancer this year. Fewer, however, are fighting the disease alongside their wives.
Before taking finasteride, tell your doctor if you have ever had an allergic reaction to this medication, or to a similar medicine called dutasteride (Avodart). Finasteride should never be taken by a woman or a child. Finasteride can be absorbed through the skin, and women or children should not be permitted to handle finasteride tablets. Although finasteride is not for women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Finasteride tablets should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a broken or crushed tablet, wash the area with soap and water right away. Call your doctor at once if you notice any breast lumps, pain, nipple discharge, or other breast changes. These may be signs of male breast cancer ...
One would think the steroid issue would have evaporated (or deflated) back in the 1980s when the rumored side-effects included shrunken testicles and the development of male breasts. But tell that to Coach Klapp, who today would resemble the superhero The Thing in the recent movie Fantastic Four.
TY - JOUR. T1 - Male breast carcinoma and gynecomastia. T2 - Comparison of mammography with sonography. AU - Jackson, Valerie. AU - Gilmor, R. L.. PY - 1983. Y1 - 1983. N2 - Both ultrasonography and x-ray mammography were performed on a male patient who had breast carcinoma. While the x-ray mammographic features were highly suggestive of malignancy, the sonographic findings were subtle. Because of the technical difficulties associated with x-ray mammography of the male breast, ultrasound has been advocated for the evaluation of gynecomastia and breast masses in men. A review of both the ultrasound scans and x-ray mammograms obtained over a three year period of 41 men who had breast enlargement shows the two modalities to be complementary. There was overlap in the appearance of benign and malignant disease on images of each modality alone, and the use of both modalities in the examination of each patient is believed to improve diagnostic accuracy.. AB - Both ultrasonography and x-ray mammography ...
What is the difference between gynecomastia male breast cancer - What is the difference between gynecomastia male breast cancer? Benign vs malignant. Gynecomastia is a benign condition usually caused by drug abuse or prescription medications. On the other hand, male breast cancer is malignant and can spread through metastasis. Fortunately it is rare for males to develop breast cancer.
BACKGROUND: Male breast cancer (MBC) is rare. The objective of the study is to report clinicopathological characteristics, treatment patterns, and outcomes of MBC. METHODS: This study, which includes two parts (retrospective and prospective), focused on all hospitalized male patients with breast cancer during 17 years (1992 2008) with histological confirmation. RESULTS: The series included 22 patients. The mean age was 52.8 years (range: 28 80 years). MBC represented 5.7% of all breast cancers. Most patients had an advanced disease with skin ulceration and inflammation T3 (31.9%) and T4 (59.1%). The majority of patients came from rural areas (63.6%). The duration of signs ranged from 1 to 7 years. Histology found infiltrating ductal carcinoma in 14 cases (63.6%), sarcoma in 3 cases (13.6%), papillary carcinoma in 2 cases (9%), and lobular carcinoma, medullar carcinoma, and mucinous carcinoma in 4.6% each of the others cases. The treatment had consisted to a radical mastectomy (Halsted or Patey) in 19
February 2010. Prescribers are advised that case reports of breast cancer have been reported in male patients following the use of finasteride.. Finasteride is a specific inhibitor of type II 5α-reductase, an intracellular enzyme that metabolises testosterone into the more potent androgen dihydrotestosterone (DHT).1. Finasteride is approved in New Zealand for the treatment of benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair loss). The recommended dose for treatment of BPH is 5mg daily; the recommended dose for male pattern hair loss is 1mg daily.1,2. The United Kingdom Medicines and Healthcare products Regulatory Agency (MHRA) has recently published a report on the possible association between the use of finasteride and breast cancer in males. The MHRA has concluded that an association can not be excluded.3. Up to November 2009, fifty cases of male breast cancer have been reported worldwide with 5 mg finasteride and three cases with the 1 mg dose. However, ...
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NEC of the breast is a rare disease. Only 6 case series have been reported in the literature, the largest comprising 74 cases [6-11]. With the 142 SEER cases reported here, this is the largest series reported to date and the first population study of mammary NEC.. The incidence of NEC of the breast has not been reported. Although NEC was estimated in 2003 to represent 2-5% of breast carcinomas [13], we found from our analysis of SEER data released in April 2012 that the incidence of mammary NEC is much lower. The age-adjusted incidence is 0.41 per 1 million-years in the female population of the U.S., and NEC comprises ,0.1% of all mammary carcinomas. Despite the low incidence of male breast carcinomas overall, the SEER data showed that NEC was proportionally more common in men than IMC-NOS (2.1% of all NEC; 0.8% of all IMC-NOS).. Because mammary NEC has not been well studied, its clinicopathologic features and outcome are poorly characterized. Among the 6 reported series studies, 2 studies with ...
Gynecomastia is a condition characterized by abnormally enlarged male breasts. There are multiple origins of the disorder. Some of them are congenital and some are acquired. One of the most common causes of gynecomastia is related to the endocrine system, and caused by excess female hormones.
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Gynecomastia is a condition of excessively large breasts in a male. Most commonly it is associated with over weight teen boys. In addition male breasts can occur in teens who smoke massive amounts of Marijuana. THC (tetra-hydra-cannibinol) the active ingrediant in maryjane/reefer/spliff/loud ( depending on your generation) blocks the Testosterone receptors resulting in feminization. Most young adult Gynecomastic happens for unknown reasons. Gynecomastia in middle aged and elderly men is associated with erectile dysfunction, potbellys and a shrinking scrotum. In these cases the aging process lowers lean body mass and Testosterone levels. Common condition and medications can also be associated with the development of breast tissue in men. Prostate cancer treatment is just one well established cause.. ...
Breast tissue is present in men though it is small in amount and does not function the way it does in women. Men can suffer from breast cancer too but it is quite rare and uncommon when compared to cases in women.
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I am a 25 year old overweight male. I have recently been diagnosed with unilateral gynecomastia ( I thought I had male breast cancer). I have read that bilateral gynecomastia could be a sign of tes...
18. Oklahoma state Sen. Judy Eason McIntyre is a survivor and a tireless advocate for breast cancer research. She was diagnosed in August of 2006 and received a double mastectomy to reduce the chances of the disease coming back. (Flickr ...
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. ...
If several members of your family have had breast or prostate cancer and particularly if there are any incidences of male breast cancer, talk to your doctor.
It may be more prominent in the upper outer quadrant and, more importantly, it blends into the surrounding fat.. If you think about the mammogram on the left as the breast of a woman instead of a man, than you might say that there is an ill-defined mass and you might conclude that this is a malignancy ...
Case Reports in Radiology is a peer-reviewed, Open Access journal that publishes case reports and case series in all areas of radiology.
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Gynecomastia is a condition of male breast enlargement due to disproportion of estrogen-to-androgen ratio. True gynecomastia is usually differentiated from excessive adipose tissue deposition with the firm consistency and its tenderness upon palpation. This condition can occur as a normal physiological process or pathologic conditions such as excessive oestrogen or androgen deficiency. Occasionally, some long term medications such as Spironolactone, Phytoestrogens, Digitalis or Ketoconazole can cause gynecomastia and it is reversible after stopping the medications.. Physiological gynecomastia happens in newborn due to transplacental transfer of oestrogen from mother to the baby, during the earlier stage of puberty where the oestrogen-to-androgen ratio is high, and in individuals who have a higher amount of fatty tissue with elevated aromatase activity. However, gynecomastia can sometimes be an indicator for a doctor to suspect for underlying diseases. Gynecomastia can be a characteristic feature ...
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A lot of Adult males dont recognize that In combination with testosterone, they also have estrogen (the female sexual intercourse hormone) in their own bodies. These hormones are answerable for managing the development of male and female sex characteristics along with the equilibrium of each Engage in a significant position in muscle mass mass and hair progress in Males. Estrogen is liable for the event of feminine characteristics, such as breast advancement. When estrogen is away from stability click here while in the male entire body, among the Negative effects might be irregular breast progress or gynecomastia. We see several Long Island and gynecomastia NYC sufferers within our offices that arent aware that this is the reason for their situation. Gynecomastia can take place at any phase of everyday living. For much more than 50 % of all male infants (Mayo Clinic, 2011), male breast enlargement can happen because of excessive of the mothers estrogen remaining within the toddlers process ...
Gynecomastia is enlargement of the glandular tissue of the male breast. It may occur during infancy and puberty in normally-developing boys. True gynecomastia results from growth of the glandular, or breast tissue.
Gynecomastia, the growth of breast tissue in cis men and intersex people with Y chromosomes, is caused by hormone imbalance. If you are experiencing gynecomastia, bioidentical hormone replacement may be able to restore your hormones to their natural levels and is available in Tempe, AZ.
Asymmetrical Gynecomastia is a condition where one breast looking different from the other breast. Asymmetrical Gynecomastia surgery is best option to remove excessive glandular tissues and fat deposits from male breast to improve chest shape.
Gynecomastia means enlargement of male breasts. This condition is quite common among boys and men that can be the reason for depression. Gynecomastia
Gynecomastia is a social and Actual physical problem that is because of enlarged male breast. A affected individual stated to me after: It really is a gorgeous day and I cant delight in it The rationale is the fact that I am unable to acquire off my shirt while in the pool,Beach front or other public destinations.This is a really harsh assertion and is attribute to those who are afflicted by the greater sever sort of the condition that is referred to as Gynecomastia. Psychologically it can be devastating,particularly in adolescence and might influence there social everyday living ...
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Children taking the antipsychotic drug, Risperdal, may be at risk for symptoms associated with gynecomastia, a condition referring to male breast growth.
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ICD-10 C50.911 is malignant neoplasm of unspecified site of right female breast (C50911). This code is grouped under diagnosis codes for neoplasms.
Save time learning, be better prepared and learn everything about this topic: Structures of the female breast seen on a sagittal section and anterolateral view.
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1 in 5 adult males in the UK is affected by gynecomastia/man boobs. Not everyone knows how to get rid of gynecomastia. We provide the best treatment options.
In addition, actual hormone therapy performed by a doctor is expensive and who even knows what this type of therapy can cause in our body
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Can a substantial chest be reduced with exercise? Im not a particularly fat person, my BMI is about 23 and my body fat % is approximately 20%. I was...
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Background: Metastasis is important in survival and the quality of life of female breast cancer patients. This study was run in order to investigate metastasis and its related factors in female breast cancer patients in Kerman province from 2005 to 2015. The aim of this study was to investigate the factors associated with secondary metastasis in female breast cancer patients in the largest province of Iran (Kerman). Materials and Methods: In this case-control study, medical records of women diagnosed with breast cancer between the years of 2005 to 2015 were studied. Among them, 200 breast cancer patients with secondary metastasis were randomly selected as cases and 400 patients without metastasis were selected as the control group. Backward logistic regression, chi-square test, t-test and Mann-Whitney-U test were performed for comparing the two groups in SPSS 22. Results: Disease stage at diagnosis was significantly associated with secondary metastasis (p|0.001). Female patients with stage III breast
The male children of mothers who were, during pregnancy of those children, exposed to high levels of toxic dioxins due to the ... In 2009, an update including 5 more years (up to 1996) found an increase in "lymphatic and hematopoietic tissue neoplasms" and ... increased breast cancer.[11]. ... "Out for the count: Why levels of sperm in men are falling". The ...
... skull base neoplasms MeSH C04.588.149.828 --- spinal neoplasms MeSH C04.588.180.260 --- breast neoplasms, male MeSH C04.588. ... vaginal neoplasms MeSH C04.588.945.418.968 --- vulvar neoplasms MeSH C04.588.945.440 --- genital neoplasms, male MeSH C04.588. ... anal gland neoplasms MeSH C04.588.274.476.411.445 --- duodenal neoplasms MeSH C04.588.274.476.411.501 --- ileal neoplasms MeSH ... femoral neoplasms MeSH C04.588.149.721 --- skull neoplasms MeSH C04.588.149.721.450 --- jaw neoplasms MeSH C04.588.149.721. ...
... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ... "Validation of salivary testosterone as a screening test for male hypogonadism". Aging Male. 9: 165-9. doi:10.1080/ ... A 2000 study compared the salivary levels of a breast cancer marker (HER2/neu) in healthy women, women with benign breast ... compared saliva from breast cancer patients to that from healthy individuals and observed, notably, that breast cancer patients ...
... breast cyst MeSH C17.800.090.500 --- breast neoplasms MeSH C17.800.090.500.260 --- breast neoplasms, male MeSH C17.800.090.500. ... sebaceous gland neoplasms MeSH C17.800.882.743 --- sweat gland neoplasms MeSH C17.800.893.592 --- leg ulcer MeSH C17.800. ... 390 --- carcinoma, ductal, breast MeSH C17.800.090.500.762 --- phyllodes tumor MeSH C17.800.090.750 --- fibrocystic breast ... sebaceous gland neoplasms MeSH C17.800.804.066 --- acrodermatitis MeSH C17.800.804.150 --- dyskeratosis congenita MeSH C17.800. ...
... (male breast neoplasm) is a rare cancer in males that originates from the breast. Many males with breast ... Chronic alcoholism has been linked to male breast cancer. The highest risk for male breast cancer is carried by males with ... Male BRCA mutation carriers are thought to be at higher risk for breast cancer as well, with roughly 10% of male breast cancer ... "Breast Cancer in Men". Cancer Research UK. 2007. Retrieved 2010-05-14. "Breast Cancer in Men" (PDF). American Cancer Society. ...
Malignant neoplasm of breast (C51) Malignant neoplasm of vulva (C52) Malignant neoplasm of vagina (C53) Malignant neoplasm of ... Benign neoplasm of ovary (D28) Benign neoplasm of other and unspecified female genital organs (D29) Benign neoplasm of male ... Malignant neoplasm of testis (C63) Malignant neoplasm of other and unspecified male genital organs (C64) Malignant neoplasm of ... Neoplasms. (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and ...
... neoplasms, and respiratory disease. The two most common cancers are prostate cancer and breast cancer. The measles immunisation ... As of 2013, life expectancy for females was 85 and for males 80. Infant mortality in 2002 was 5 per 1,000 live births, ... May 2010). "Worldwide mortality in men and women aged 15-59 years from 1970 to 2010: a systematic analysis". Lancet. 375 (9727 ... place Cyprus as the country with the lowest mortality for females and 14th lowest mortality for males. The Euro health consumer ...
The incidence of mammary desmoid tumours is less than 0.2% of primary breast neoplasms. In Gardner's syndrome the incidence ... Each of their children, male and female alike, are at 50% risk of inheriting the gene for Gardner syndrome. Gardner syndrome is ... The extra-abdominal form is rare and desmoids of the breast may arise in the mammary gland or may occur as an extension of a ... Rammohan A, Wood JJ (2012). "Desmoid tumour of the breast as a manifestation of Gardner's syndrome". Int J Surg Case Rep. 3 (5 ...
A urogenital neoplasm is a tumor of the urogenital system. Types include: Cancer of the breast and female genital organs: ( ... Cancer of the male genital organs (Carcinoma of the penis, Prostate cancer, Testicular cancer) Cancer of the urinary organs ( ... Breast cancer, Vulvar cancer, Vaginal cancer, Cervical cancer, Uterine cancer, Endometrial cancer, Ovarian cancer) ...
This compares with 73% for affected males. The difference may be due to much smaller breast tissue in males as well as ... link) Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". ... Erratum for "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms"". Science. 259 ( ... 1990). "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms". Science. 250 (4985): ...
Other malignant neoplasm of skin (174) Malignant neoplasm of female breast (175) Malignant neoplasm of male breast (176) ... Benign neoplasm of male genital organs (223) Benign neoplasm of kidney and other urinary organs (224) Benign neoplasm of eye ( ... Malignant neoplasm of prostate (186) Malignant neoplasm of testis (187) Malignant neoplasm of penis and other male genital ... Benign neoplasm of breast (218) Uterine leiomyoma (219) Other benign neoplasm of uterus (220) Benign neoplasm of ovary (221) ...
... even in the absence of a breast-cancer gene.[69] Similarly, men of African ancestry have significantly higher levels of ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis. Also, when ...
... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ... The smaller gamete is the sperm cell and is produced by males of the species. The larger gamete is the ovum and is produced by ... Immunocontraception targeting the male gamete has involved many different antigens associated with sperm function. The zona ... In this way antibodies generated by the male are deposited into the female along with spermatozoa. Because of this and the ...
... is a salivary gland neoplasm that shares a genetic mutation with certain types of breast cancer. MASCSG was first described by ... Mammary analogue secretory carcinoma occurs somewhat more commonly in men (male to female ratio of ... This mutant fusion gene also occurs in congenital fibrosarcoma, congenital mesoblastic nephroma, secretory breast cancer (also ... a subtype of invasive ductal carcinoma of the breast. The translocation found in MASCSG occurs between the ETV6 gene located on ...
Receptor Positive Breast Tumor Subtypes". Journal of Breast Cancer. 20 (2): 198-202. doi:10.4048/jbc.2017.20.2.198. PMID ... MORT RNA expression and DNA methylation state were evaluated in the 10 most common male cancers and the 10 most common female ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, and ... Indeed, recent work has shown that MORT is epigenetically silenced in both DCIS, a premalignant lesion of invasive breast ...
These skin lesions develop on the trunk, extremities, and face, and are almost twice as common in men than in women, especially ... It is likely directly induced by an underlying neoplasm secreting a growth factor. One candidate may be alpha-transforming ... FCP is associated with underlying cancer of the breast, bladder, ovary, uterus, prostate, and lung. Other associated underlying ... Florid cutaneous papillomatosis is almost twice as common in men than in women, and is usually diagnosed in individuals aged 53 ...
Szabo S, Haislip A, Garry R (2005). "Of mice, cats, and men: is human breast cancer a zoonosis?". Microsc Res Tech. 68 (3-4): ... A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are ... They occur in male and female rats. The tumors can be large and occur anywhere on the trunk. There is a good prognosis with ... There is a much lower risk (about 1 percent) in male dogs and a risk in cats about half that of dogs. The exact causes for the ...
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Carney Complex, type 1; CNC1 (OMIM 160980) omim.org OMIM-Online Mendelian Inheritance in Man. Carney Complex, type 2; CNC2 ( ... Soga, J.; Osaka, M.; Yakuwa, Y. (2001). "Gut-endocrinomas (carcinoids and related endocrine variants) of the breast: An ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ...
It is also used to treat breast development and small penis in males.[1] It is typically given as a gel for application to the ... "Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Sartorelli AC, Johns DJ (eds.). Antineoplastic ... Notes: Men produce about 3 to 11 mg testosterone per day (mean 7 mg/day in young men). Footnotes: a = Never marketed. b = No ... breast atrophy, and muscle hypertrophy, as well as menstrual disturbances and reversible infertility.[35][36] In men, the ...
... even in the absence of a breast-cancer gene. Similarly, men of African ancestry have significantly higher levels of ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis. Also, when ... for breast cancer, see Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, et al. (February 2009). "Breast ...
Feb 2006). "Male breast cancer". Lancet. 367 (9510): 595-604. doi:10.1016/S0140-6736(06)68226-3. PMID 16488803. Gavaler, JS. ( ... and malignant neoplasms. The psychiatric disorders which are associated with alcoholism include major depression, dysthymia, ... Weiss, JR.; Moysich, KB.; Swede, H. (Jan 2005). "Epidemiology of male breast cancer". Cancer Epidemiol Bio-markers Prev. 14 (1 ... men), breast (pre- and postmenopause). Acetaldehyde, a metabolic product of alcohol, is suspected to promote cancer. Typically ...
Myxomas may also occur outside the heart, usually in the skin and breast. Endocrine tumors may manifest as disorders such as ... Online Mendelian Inheritance in Man (OMIM) Carney Complex, type 1; CNC1 -160980 Stratakis, C. A.; Kirschner, L. S.; Carney, J. ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ... Online Mendelian Inheritance in Man (OMIM) Carney Complex, type 2; CNC2 -605244 Tsay CJ, Stratakis CA, Faucz FR, London E, ...
For example, a male may develop breasts and other feminine characteristics, while a female may develop a deepened voice and ... Central precocious puberty can be caused by intracranial neoplasm, infection (most commonly central nervous system tuberculosis ... Studies indicate that breast development in girls and the appearance of pubic hair in girls and boys are starting earlier than ... Males and females are hyperfeminized by the syndrome. Many causes of early puberty are somewhat unclear, though girls who have ...
Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. ... Some benign tumors are not true neoplasms, but rather, represent hamartomas, namely the osteochondroma. The most common ... penis/testes in males and vagina/vulva in females). This operation is done in two stages. First stage is doing the colostomy ... most commonly carcinomas of the breast, lung, and prostate. Reliable and valid statistics on the incidence, prevalence, and ...
The lymphoma is more common in the young and in males. A 2008 study found an increased risk of ALCL of the breast in women with ... Because approximately 70% of ALCL neoplasms are also ALK positive, there is hope that similar highly selective and potent ALK ... A rare subtype of ALCL has been identified in a few women who have silicone breast implants (protheses) as a result of breast ... a cytologic specimen of the effusion around the breast implant or complete examination of the breast capsule surrounding the ...
Isabel Woodman, "Breast feeding reduces risk of breast cancer, says study," British Medical Journal, v.); Jul 27, 2002 ... For example, the FGR 13 has estimated that the ratio of thyroid cancer incidence for women as compared to men is 2.14, while ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... However, women develop cancer from radiation at a rate from 37.5% to 52% higher than that of men. In recent years, studies ...
Male Breast Neoplasms anonymous support group with inform... ... people sharing true stories in the I Have Male Breast Neoplasms ... Do You Have Male Breast Neoplasms? Join friendly ... I Have Male Breast Neoplasms does not have any stories yet. Be ... Male Breast Neoplasms anonymous support group with information on diagnosis, treatment, symptoms, along with personal stories ... and experiences with Male Breast Neoplasms. Youre not alone. Report Group. ...
C50.422 Malignant neoplasm of upper-outer quadrant of left male breast C50.429 Malignant neoplasm of upper-outer quadrant of ... C50.322 Malignant neoplasm of lower-inner quadrant of left male breast C50.329 Malignant neoplasm of lower-inner quadrant of ... C50.42 Malignant neoplasm of upper-outer quadrant of breast, male C50.421 Malignant neoplasm of upper-outer quadrant of right ... C50.52 Malignant neoplasm of lower-outer quadrant of breast, male C50.521 Malignant neoplasm of lower-outer quadrant of right ...
C50.322 Malignant neoplasm of lower-inner quadrant of left male breast C50.329 Malignant neoplasm of lower-inner quadrant of ... Malignant neoplasm of lower-inner quadrant of unspecified male breast. 2016 2017 2018 2019 2020 Billable/Specific Code Male Dx ... C50.222 Malignant neoplasm of upper-inner quadrant of left male breast C50.229 Malignant neoplasm of upper-inner quadrant of ... C50.32 Malignant neoplasm of lower-inner quadrant of breast, male C50.321 Malignant neoplasm of lower-inner quadrant of right ...
C50.12 Malignant neoplasm of central portion of breast, male C50.121 Malignant neoplasm of central portion of right male breast ... C50.021 Malignant neoplasm of nipple and areola, right male breast C50.022 Malignant neoplasm of nipple and areola, left male ... Malignant neoplasm of nipple and areola, right male breast. 2016 2017 2018 Billable/Specific Code Male Dx *C50.021 is a ... C50.019 Malignant neoplasm of nipple and areola, unspecified female breast C50.02 Malignant neoplasm of nipple and areola, male ...
Male Breast , Male Breast Cancer , Male Breast Carcinoma , Male Breast Neoplasm , Male Breast Neoplasms , Male Breast Tumor , ... Male Breast Tumors , Neoplasm, Male Breast , Neoplasms, Breast, Male , Neoplasms, Male Breast , Tumor, Male Breast , Tumors, ... Breast Neoplasms, Male Synonyms Breast Cancer, Male , Breast Carcinoma, Male , Breast Neoplasm, Male , Breast Tumor, Male , ... Diseases ← NeoplasmsNeoplasms by Site ← Breast NeoplasmsBreast Neoplasms, Male 2.. Diseases ← Skin and Connective Tissue ...
Malignant neoplasm of lower-inner quadrant of left male breast. 2016 2017 2018 2019 Billable/Specific Code Male Dx *C50.322 is ... C50.321 Malignant neoplasm of lower-inner quadrant of right male breast C50.322 Malignant neoplasm of lower-inner quadrant of ... C50.221 Malignant neoplasm of upper-inner quadrant of right male breast C50.222 Malignant neoplasm of upper-inner quadrant of ... C50.42 Malignant neoplasm of upper-outer quadrant of breast, male C50.421 Malignant neoplasm of upper-outer quadrant of right ...
C50.622 Malignant neoplasm of axillary tail of left male breast C50.629 Malignant neoplasm of axillary tail of unspecified male ... C50.82 Malignant neoplasm of overlapping sites of breast, male C50.821 Malignant neoplasm of overlapping sites of right male ... C50.829 Malignant neoplasm of overlapping sites of unspecified male breast C50.9 Malignant neoplasm of breast of unspecified ... Malignant neoplasm of axillary tail of unspecified male breast. 2016 2017 2018 2019 Billable/Specific Code Male Dx *C50.629 is ...
Here, we report the case of a 57-year-old man who was referred to our institution with synchronous squamous cell carcinoma of ... To the best of our knowledge, this is the first reported case in literature of this combination of primary neoplasms. ... the skin on the forehead, infiltrating ductal carcinoma of the breast, and transitional cell carcinoma of the urinary bladder. ... The incidence of multiple primary malignant neoplasms increases with age, reflecting an increase in overall cancer risk in ...
C50.921 Malignant neoplasm of unspecified site of right male breast C50.922 Malignant neoplasm of unspecified site of left male ... C50.829 Malignant neoplasm of overlapping sites of unspecified male breast C50.9 Malignant neoplasm of breast of unspecified ... Malignant neoplasm of unspecified site of unspecified male breast. 2016 2017 2018 Billable/Specific Code Male Dx *C50.929 is a ... Secondary malignant neoplasm of lymph node from neoplasm of male breast. ICD-10-CM C50.929 is grouped within Diagnostic Related ...
... male (C5042). This code is grouped under diagnosis codes for neoplasms. ... ICD-10 C50.42 is malignant neoplasm of upper-outer quadrant of breast, ... Malignant neoplasm of axillary tail of right male breast. 62. C50.622. Malignant neoplasm of axillary tail of left male breast ... Malignant neoplasm of central portion of breast, male. 17. C50.121. Malignant neoplasm of central portion of right male breast ...
... male (C5032). This code is grouped under diagnosis codes for neoplasms. ... ICD-10 C50.32 is malignant neoplasm of lower-inner quadrant of breast, ... Malignant neoplasm of axillary tail of right male breast. 62. C50.622. Malignant neoplasm of axillary tail of left male breast ... Malignant neoplasm of central portion of breast, male. 17. C50.121. Malignant neoplasm of central portion of right male breast ...
Breast cancer in male patient has a worse prognosis than female patients, due to lower amount of tissue in breast exposed to an ... 53 -year-old male diagnosed with right breast cancer, infiltrating ductal adenocarcinoma type, clinical stage IIB, breast ... Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In ... Breast cancer in males, case presentation and literature review. [Article in Spanish; Abstract available in Spanish from the ...
The ICD-10 Code C50.029 is the code used for Malignant neoplasm of nipple and areola, unsp male breast .An alternative ... description for this code is Malignant neoplasm of nipple and areola, unspecifi. ...
The ICD-10 Code C50.121 is the code used for Malignant neoplasm of central portion of right male breast .An alternative ... description for this code is Malignant neoplasm of central portion of right mal. ...
The ICD-10 Code C50.129 is the code used for Malignant neoplasm of central portion of unsp male breast .An alternative ... description for this code is Malignant neoplasm of central portion of unspecifi. ...
C50.92 Malignant neoplasm of breast of unspecified site, male NON-BILLABLE * * BILLABLE C50.921 Malignant neoplasm of ... BILLABLE C50.922 Malignant neoplasm of unspecified site of left male breast * BILLABLE C50.929 Malignant neoplasm of ... Malignant neoplasm of breast of unspecified site, male NON-BILLABLE Non-Billable Code Non-Billable means the code is not ... ICD-10-CM Alphabetical Index References for C50.92 - Malignant neoplasm of breast of unspecified site, male The ICD-10-CM ...
Breast Neoplasms, Male. D018567. EFO:0006861. male breast carcinoma. 2. ClinicalTrials. Carcinoma, Non-Small-Cell Lung. D002289 ... Breast Neoplasms. D001943. EFO:0000305. breast carcinoma. 2. ClinicalTrials. ClinicalTrials. Colonic Neoplasms. D003110. EFO: ... Uterine Neoplasms. D014594. EFO:0003859. uterine neoplasm. 1. ClinicalTrials. Acute Lung Injury. D055371. EFO:0004610. acute ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ClinicalTrials. ATC. ClinicalTrials. Histiocytoma. D051642. EFO:0005561. ...
Breast Neoplasm. *Breast Neoplasm, Male. *Triple Negative Breast Cancer. *Drug: Cyclophosphamide. *Drug: Indomethacin ... Study of Hypofractionated Partial Breast Irradiation in Women With Early Stage Breast Cancer. *Malignant Neoplasm of Breast ... Comparison of the Breast Tumor Microenvironment. *Triple Negative Breast Cancer. *Hormone Receptor Positive Malignant Neoplasm ... Window of Opportunity Trial of Dasatinib in Operable Triple Negative Breast Cancers With nEGFR. *Breast Neoplasms ...
The ICD-10 Code C50.422 is the code used for Malig neoplasm of upper-outer quadrant of left male breast .An alternative ... description for this code is Malignant neoplasm of upper-outer quadrant of left. ...
Malignant neoplasm of unspecified site of left male breast BILLABLE Billable Code Billable codes are sufficient justification ... C50.922 is a billable ICD code used to specify a diagnosis of malignant neoplasm of unspecified site of left male breast. A ... Malignant neoplasm of other and unspecified sites of male breast (approximate match) ... The ICD code C50 is used to code Urogenital neoplasm A urogenital neoplasm is a tumor of the urogenital system. ...
Male Breast Cancer Although breast cancer is much more common in women, men can get it too. It happens most often to men ... Neoplasms (C00-D48) * Malignant neoplasms of breast (C50) * Malignant neoplasm of breast (C50) ... unsp male breast Long Description: Malignant neoplasm of nipple and areola, unspecified male breast This is the 2019 version of ... C50.029 - Malignant neoplasm of nipple and areola, unsp male breast. ICD-10 Diagnosis Code C50.029. Malignant neoplasm of ...
Breast Neoplasms. Breast Neoplasms, Male. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. ... MedlinePlus related topics: Breast Cancer Male Breast Cancer Genetic and Rare Diseases Information Center resources: Breast ... Male Breast Cancer: Understanding the Biology for Improved Patient Care. The safety and scientific validity of this study is ... All men, with histologically proven invasive breast cancer, newly presenting at the center irrespective of the stage of disease ...
Breast Neoplasms. Breast Neoplasms, Male. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Finasteride. 5-alpha ... Men with Breast Cancer Breast cancer cases among men aged 35 years and above in the registries of Denmark (1995-2013), Finland ... Men without Breast Cancer Country- and age-matched controls: men without breast cancer aged 35 years and above in the ... Finasteride (MK-0906) and Male Breast Cancer - A Register-Based Nested Case-Control Study (MK-0906-162/2003.021).. The safety ...
Breast Neoplasms Breast Diseases Neoplasms Neoplasms by Site Fulvestrant Antineoplastic Agents Antineoplastic Agents, Hormonal ... Breast Neoplasms. Neoplasms. Breast Diseases. Neoplasms by Site. Skin Diseases. Fulvestrant. Estradiol. Antineoplastic Agents, ... Study of Efficacy and Safety of LEE011 in Men and Postmenopausal Women With Advanced Breast Cancer. (MONALEESA-3). The safety ... placebo controlled trial in men and post-menopausal women with advanced breast cancer. ...
Breast Neoplasms, Male. Breast Neoplasms. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Tamoxifen. Exemestane. ... Keywords provided by German Breast Group: Male breast cancer. neoadjuvant, adjuvant or metastatic situation. anti-hormonal ... Breast cancer in men is a rare disease with approximately 0.5- 1% of all breast cancer cases. Each year, about 400 to 450 cases ... Men tend to present with more advanced disease than women, probably due to the lack of awareness of male breast cancer from ...
  • The best-studied examples in this context are carcinomas of the prostate and the breast. (nih.gov)
  • Dutasteride in combination with the alpha adrenergic antagonist, tamsulosin, is indicated for the treatment of symptomatic BPH in men with an enlarged prostate. (nih.gov)
  • Dutasteride and tamsulosin hydrochloride capsules are indicated for the treatment of symptomatic BPH in men with an enlarged prostate. (nih.gov)
  • Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys are the carcinomas that most commonly metastasize to bone. (wikipedia.org)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • In a number of situations direct medical or surgical intervention can improve the sperm concentration, examples are use of FSH in men with pituitary hypogonadism, antibiotics in case of infections, or operative corrections of a hydrocele, varicocele, or vas deferens obstruction. (wikipedia.org)
  • paciente masculino de 53 años de edad, con diagnóstico de cáncer de mama derecha, tipo adenocarcinoma canalicular infiltrante, estadio clínico IIB, con antecedentes de cáncer de mama en 2 familiares directos, mutaciones del gen BRCA1 y positivo tanto a receptores hormonales como para el gen Her2/Neu. (nih.gov)
  • The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. (nih.gov)
  • Lesions are less contained in males as they do not have to travel far to infiltrate skin, nipple, or muscle tissue. (wikipedia.org)
  • Breasts are made of lobules (milk producing glands) and ducts (tubes that carry the milk to the nipple). (wikipedia.org)
  • Breast and trunk lymphedema can also occur but, go unrecognised as there is swelling in the area after surgery and its symptoms ( peau d' orange and/or an inverted nipple ) can be confused with post surgery fat necrosis. (wikipedia.org)
  • The study was a Phase 1 clinical study in hypogonadal men, defined according to FDA and Endocrine Society Guidelines, designed to evaluate the pharmacokinetic (PK) characteristics of DITEST, and to assess the safety and tolerability of DITEST in the target population. (clinicaltrials.gov)
  • A systematic population analysis of deaths in the adult population (ages 15-59) and released in 2010 in The Lancet, place Cyprus as the country with the lowest mortality for females and 14th lowest mortality for males. (wikipedia.org)
  • Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens (male hormones) in females. (wikipedia.org)
  • In the few cases described in the literature to date, the male-to-female ratio is approximately unity, and right lung lesions occurred twice as commonly as left lung lesions. (wikipedia.org)
  • Lung hamartomas are more common in men than in women, and may present additional difficulties in smokers. (wikipedia.org)
  • Fourteen cases of breast lymphoma, identified from hospital records between 1990 and 2004, were reclassified according to the World Health Organisation criteria. (biomedsearch.com)
  • In order to investigate the pineal function and its relation with the hypophysis in human neoplasms, melatonin and GH serum levels were determined in 63 patients, 42 affected by solid tumours and 21 by lymphoma or leukaemia. (nih.gov)
  • The extra-abdominal form is rare and desmoids of the breast may arise in the mammary gland or may occur as an extension of a lesion arising from the muscles of the chest wall. (wikipedia.org)
  • Myxomas may also occur outside the heart, usually in the skin and breast. (wikipedia.org)
  • Both groups occur mainly (but not exclusively) in people over 40, and are slightly more common in men, but some rare sub-types mainly occur in women or children. (wikipedia.org)
  • In these cases, untreated survival usually amounts to only a few months, and survival with current radiation and chemotherapy treatments may extend that time from around a year to a year and a half, possibly two or more, depending on the patient's condition, immune function, treatments used, and the specific type of malignant brain neoplasm. (wikipedia.org)
  • A MEDLINE search from January 1990 to May 1998 was performed using the terms genetic breast screening, BRCA1, and BRCA2. (nih.gov)
  • The prospective 'screening with tomosynthesis or standard mammography' (STORM) trial recruited women participating in biennial breast screening in Italy (2011-2012), and compared sequential screen-rea. (bioportfolio.com)
  • An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women. (bioportfolio.com)
  • An Open-label, Two-part, Multi-center Dose-finding Study in Healthy Male Volunteers and Women Who Have Previously Received Herceptin to Compare Exposure of Single Dose Trastuzumab After Intravenous (IV) and Subcutaneous (SC) Administration. (knowcancer.com)
  • These skin lesions develop on the trunk, extremities, and face, and are almost twice as common in men than in women, especially individuals aged 53-72 years. (wikipedia.org)
  • Florid cutaneous papillomatosis is almost twice as common in men than in women, and is usually diagnosed in individuals aged 53-72 years (mean patient age, 58.5 years). (wikipedia.org)
  • It is less common in women than men. (wikipedia.org)
  • Common side effects of non-contraceptive (i.e., high) dosages of CPA in men include gynecomastia (breast development) and feminization in general and in both men and women include low sex hormone levels, reversible infertility, sexual dysfunction, mental symptoms like depression, fatigue, and irritability, vitamin B12 deficiency, and elevated liver enzymes. (wikipedia.org)
  • Folate is necessary for fertility in both men and women. (wikipedia.org)
  • Women who have sex with men who have many other sexual partners or women who have many sexual partners have a greater risk. (wikipedia.org)