Inflammatory Breast Neoplasms
Triple Negative Breast Neoplasms
Breast
Breast Neoplasms, Male
Carcinoma, Ductal, Breast
Neoplasms
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Receptors, Estrogen
Neoplasms, Cystic, Mucinous, and Serous
Fibrocystic Breast Disease
A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Immunohistochemistry
Neoplasms, Multiple Primary
Receptor, erbB-2
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Neoplasm Staging
Breast Implants
Receptors, Progesterone
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
Gene Expression Regulation, Neoplastic
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Breast Self-Examination
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Neoplasm Metastasis
Prognosis
Tamoxifen
Carcinoma, Intraductal, Noninfiltrating
Ovarian Neoplasms
Carcinoma
Adenocarcinoma, Mucinous
Carcinoma, Lobular
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Risk Factors
Neoplasm Recurrence, Local
Lymphatic Metastasis
Ultrasonography, Mammary
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Genes, BRCA1
Antineoplastic Agents, Hormonal
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Tumor Cells, Cultured
Myeloproliferative Disorders
Mammary Neoplasms, Experimental
Neoplasms, Radiation-Induced
Antigens, Neoplasm
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Postmenopause
Fibroadenoma
Chemotherapy, Adjuvant
Mastectomy, Segmental
Cystadenoma
Neoplasms, Connective and Soft Tissue
Neoplasms, Plasma Cell
Breast Cyst
Carcinoma in Situ
Neoplasms, Experimental
Treatment Outcome
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Biopsy, Needle
Estrogen Receptor alpha
Carcinoma, Papillary
Gastrointestinal Neoplasms
Follow-Up Studies
MCF-7 Cells
Mammary Glands, Human
Cystadenoma, Mucinous
Incidence
Premenopause
Carcinoma, Pancreatic Ductal
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Neoplasms, Vascular Tissue
Neoplasm Transplantation
Menopause
Neoplasms, Hormone-Dependent
Breast Implantation
Neoplasms, Glandular and Epithelial
BRCA2 Protein
A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Adenocarcinoma, Papillary
Gene Expression Profiling
Soft Tissue Neoplasms
BRCA1 Protein
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disease-Free Survival
Testicular Neoplasms
Carcinoma, Ductal
Genetic Predisposition to Disease
Neoplasms, Muscle Tissue
Sensitivity and Specificity
Drug Resistance, Neoplasm
Mice, Nude
Antineoplastic Combined Chemotherapy Protocols
Genes, BRCA2
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Neoplasm Grading
Hematologic Neoplasms
Mutation
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Bone Marrow Neoplasms
Risk
Immunoenzyme Techniques
Neoplasms, Adnexal and Skin Appendage
Genes, erbB-2
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
Vascular Neoplasms
Colorectal Neoplasms
Biopsy
Disease Progression
Mass Screening
Aromatase Inhibitors
Estrogen Antagonists
Prospective Studies
Risk Assessment
Palatal Neoplasms
Ki-67 Antigen
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Adenofibroma
Cell Transformation, Neoplastic
Heart Neoplasms
Tissue Array Analysis
Estradiol
Meningeal Neoplasms
Cystadenoma, Serous
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Survivors
Lymph Nodes
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Dog Diseases
Cell Division
Tomography, X-Ray Computed
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Neoplasms, Germ Cell and Embryonal
Hemangiosarcoma
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Odds Ratio
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Neoplasms, Adipose Tissue
Germ-Line Mutation
In Situ Hybridization, Fluorescence
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Multivariate Analysis
Blotting, Western
Mastectomy, Modified Radical
Hyperplasia
Biopsy, Fine-Needle
Oligonucleotide Array Sequence Analysis
Gene Amplification
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Mucin-1
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Neoadjuvant Therapy
Proportional Hazards Models
Tumor Suppressor Protein p53
Precancerous Conditions
Selective Estrogen Receptor Modulators
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Diphtheria toxin effects on human cells in tissue culture. (1/42895)
HeLa cells exposed to a single sublethal concentration of diphtheria toxin were found to have diminished sensitivity when subsequently reexposed to the toxin. Three cells strains exhibiting toxin resistance were developed. In the cells that had previously been exposed to toxin at 0.015 mug/ml, 50% inhibition of protein synthesis required a toxin concentration of 0.3 mug/ml, which is more than 10 times that required in normal HeLa cells. There appears to be a threshold level of diphtheria toxin action. Concentrations of toxin greater than that required for 50% inhibition of protein synthesis (0.01 mug/ml) are associated with cytotoxicity, whereas those below this concentration may not be lethal. Several established human cell lines of both normal and neoplastic origin were tested for their sensitivity to the effects of the toxin. No special sensitivity was observed with the cells of tumor origin. Fifty % inhibition of protein synthesis of HeLa cells was achieved with diphtheria toxin (0.01 mug/ml) as compared to the normal human cell lines tested (0.03 and 0.5 mug/ml) and a cell line derived from a human pancreatic adenocarcinoma (0.2 mug/ml). A human breast carcinoma cell line showed a maximum of 45% inhibition of protein synthesis. This required a diphtheria toxin concentration of 5 mug/ml. These results suggest that different human cell lines show wide variation in their sensitivity to the toxin. (+info)The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. (2/42895)
We have established or characterized six lines of human breast cancer maintained in long-term tissue culture for at least 1 year and have examined these lines for estrogen responsiveness. One of these cell lines, MCF-7, shows marked stimulation of macromolecular synthesis and cell division with physiological concentrations of estradiol. Antiestrogens are strongly inhibitory, and at concentrations greater than 3 X 10(-7) M they kill cells. Antiestrogen effects are prevented by simultaneous treatment with estradiol or reversed by addition of estradiol to cells incubated in antiestrogen. Responsive cell lines contain high-affinity specific estradiol receptors. Antiestrogens compete with estradiol for these receptors but have a lower apparent affinity for the receptor than estrogens. Stimulation of cells by estrogens is biphasic, with inhibition and cell death at concentrations of 17beta-estradiol or diethylstilbestrol exceeding 10(-7) M. Killing by high concentrations of estrogen is probably a nonspecific effect in that we observe this response with 17alpha-estradiol at equivalent concentrations and in the otherwise unresponsive cells that contain no estrogen receptor sites. (+info)The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. (3/42895)
Glucocorticoids, at physiological concentration, inhibit cell division and thymidine incorporation in three lines of human breast cancer maintained in long-term tissue culture. At steroid concentrations sufficient to inhibit thymidine incorporation 50%, little or no effect is seen on protein synthesis 48 hr after hormone addition. All three of these lines are shown to have glucocorticoid receptors demonstrable by competitive protein binding assays. Receptors are extensively characterized in one line by sucrose density gradient analysis and binding specificity studies. Good correlation between receptor-binding specificity and biological activity is found except for progesterone, which binds to glucocorticoid receptor but is noninhibitory. Cross-competition and quantification studies demonstrate a separate receptor for progesterone. This receptor has limited binding specificities restricted largely to progestational agents, whereas the glucocorticoid receptor bound both glucocorticoids and progesterone. Two other human breast cancer lines neither contain glucocorticoid receptor nor are inhibited by glucocorticoids. It is concluded that in some cases glucocorticoids can directly limit growth in human breast cancer in vitro without requiring alterations in other trophic hormones. (+info)The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (4/42895)
We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent. (+info)Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530. (5/42895)
Elevated levels of Src kinase activity have been reported in a number of human cancers, including colon and breast cancer. We have analysed four human breast tumor cell lines that exhibit high levels of Src kinase activity, and have determined that these cell lines also exhibit a high level of a phosphotyrosine phosphatase activity that recognizes the Src carboxy-terminal P-Tyr530 negative regulatory site. Total Src kinase activity in these cell lines is elevated as much as 30-fold over activity in normal control cells and specific activity is elevated as much as 5.6-fold. When the breast tumor cells were grown in the presence of the tyrosine phosphatase inhibitor vanadate, Src kinase activity was reduced in all four breast tumor cell lines, suggesting that Src was being activated by a phosphatase which could recognize the Tyr530 negative regulatory site. In fractionated cell extracts from the breast tumor cells, we found elevated levels of a membrane associated tyrosine phosphatase activity that preferentially dephosphorylated a Src family carboxy-terminal phosphopeptide containing the regulatory tyrosine 530 site. Src was hypophosphorylated in vivo at tyrosine 530 in at least two of the tumor cell lines, further suggesting that Src was being activated by a phosphatase in these cells. In preliminary immunoprecipitation and antibody depletion experiments, we were unable to correlate the major portion of this phosphatase activity with several known phosphatases. (+info)Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells. (6/42895)
Increased breast cancer growth has been associated with increased expression of epidermal growth factor receptor (EGFR) and ErbB2 receptor tyrosine kinases (RTKs). Upon activation, RTKs may transmit their oncogenic signals by binding to the growth factor receptor bound protein-2 (Grb2), which in turn binds to SOS and activates the Ras/Raf/MEK/mitogen-activated protein (MAP) kinase pathway. Grb2 is important for the transformation of fibroblasts by EGFR and ErbB2; however, whether Grb2 is also important for the proliferation of breast cancer cells expressing these RTKs is unclear. We have used liposomes to deliver nuclease-resistant antisense oligodeoxynucleotides (oligos) specific for the GRB2 mRNA to breast cancer cells. Grb2 protein downregulation could inhibit breast cancer cell growth; the degree of growth inhibition was dependent upon the activation and/or endogenous levels of the RTKs. Grb2 inhibition led to MAP kinase inactivation in EGFR, but not in ErbB2, breast cancer cells, suggesting that different pathways might be used by EGFR and ErbB2 to regulate breast cancer growth. (+info)Increased expression of fibroblast growth factor 8 in human breast cancer. (7/42895)
Fibroblast growth factor 8 (FGF8) is an important developmental protein which is oncogenic and able to cooperate with wnt-1 to produce mouse mammary carcinoma. The level of expression of FGF8 mRNA was measured in 68 breast cancers and 24 non-malignant breast tissues. Elevated levels of FGF8 mRNA were found in malignant compared to non-malignant breast tissues with significantly more malignant tissues expressing FGF8 (P=0.019) at significantly higher levels (P=0.031). In situ hybridization of breast cancer tissues and analysis of purified populations of normal epithelial cells and breast cancer cell lines showed that malignant epithelial cells expressed FGF8 mRNA at high levels compared to non-malignant epithelial and myoepithelial cells and fibroblasts. Although two of the receptors which FGF8 binds to (FGFR2-IIIc, FGFR3-IIIc) are not expressed in breast cancer cells, an autocrine activation loop is possible since expression of fibroblast growth factor receptor (FGFR) 4 and FGFR1 are retained in malignant epithelial cells. This is the first member of the FGF family to have increased expression in breast cancer and a potential autocrine role in its progression. (+info)Estrogen-dependent and independent activation of the P1 promoter of the p53 gene in transiently transfected breast cancer cells. (8/42895)
Loss of p53 function by mutational inactivation is the most common marker of the cancerous phenotype. Previous studies from our laboratory have demonstrated 17 beta estradiol (E2) induction of p53 protein expression in breast cancer cells. Although direct effects of E2 on the expression of p53 gene are not known, the steroid is a potent regulator of c-Myc transcription. In the present studies, we have examined the ability of E2 and antiestrogens to regulate the P1 promoter of the p53 gene which contains a c-Myc responsive element. Estrogen receptor (ER)-positive T47D and MCF-7 cells were transiently transfected with the P1CAT reporter plasmid and levels of CAT activity in response to serum, E2 and antiestrogens were monitored. Factors in serum were noted to be the dominant inducers of chloramphenicol acetyltransferase (CAT) expression in MCF-7 cells. The levels of CAT were drastically reduced when cells were maintained in serum free medium (SFM). However, a subtle ER-mediated induction of CAT expression was detectable when MCF-7 cells, cultured in SFM, were treated with E2. In serum-stimulated T47D cells, the CAT expression was minimal. The full ER antagonist, ICI 182 780 (ICI) had no effect. Treatment with E2 or 4-hydroxy tamoxifen (OHT) resulted in P1CAT induction; OHT was more effective than E2. Consistent with c-Myc regulation of the P1 promoter, E2 stimulated endogenous c-Myc in both cell lines. Two forms of c-Myc were expressed independent of E2 stimuli. The expression of a third more rapidly migrating form was E2-dependent and ER-mediated since it was blocked by the full ER antagonist, ICI, but not by the ER agonist/antagonist OHT. These data demonstrate both ER-mediated and ER-independent regulation of c-Myc and the P1 promoter of the p53 gene, and show differential effects of the two classes of antiestrogens in their ability to induce the P1 promoter of the p53 gene in breast cancer cells. (+info)
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Factors Affecting the Decision of Breast Cancer Patients to Undergo Contralateral Prophylactic Mastectomy
Estradiol, Tamoxifen, and Flaxseed Alter IL-1 beta and IL-1Ra Levels in Normal Human Breast Tissue in Vivo
Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. - MRC Weatherall...
Unusual roles of caspase-8 in triple-negative breast cancer cell line MDA-MB-231<...
Pregnancy is safe for women with estrogen receptor positive breast cancer
Comprehensive molecular biomarker identification in breast cancer brain metastases | Journal of Translational Medicine | Full...
Survival of HER2-positive primary breast cancer patients treated by neoadjuvant chemotherapy plus trastuzumab: A multicenter...
TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients |...
Contralateral Prophylactic Mastectomy: Characteristics Influencing Utilization
PDF] Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. |...
Triple negative breasts cancer (TNBC) gets the poorest prognosis of most - PARG inhibitors in cancer therapy
Regulation of epidermal growth factor receptor levels by 1,25-dihydroxyvitamin D3 in human breast cancer cells | Garvan...
Evaluation of three commercial progesterone receptor assays in a single tamoxifen-treated breast cancer cohort | Modern...
Risk of type 2 diabetes mellitus in female breast cancer patients treated with morphine: A retrospective population-based time...
Mammographic features at predicting the presence of an extensive intraductal component in early stage breast carcinoma:...
Timing of radiotherapy and chemotherapy following breast-conserving surgery for patients with node-positive breast cancer
I do not even say it - A mixed methods study on breast cancer awareness of omani women<...
Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death. - Nuffield Department...
Molecular Cytogenetic Identification of Subgroups of Grade III Invasive Ductal Breast Carcinomas with Different Clinical...
Single-agent PARP inhibitors for the treatment of patients with BRCA-mutated HER2-negative metastatic breast cancer: a...
Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer | NYU Langone Health
Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer | NYU Langone Health
Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer | [email protected]
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year...
NOPR: The modulatory effect of septilin on cytotoxicity of cisplatin in a human breast adenocarcinoma cell line
Biomarker May Help Improve Treatment of Triple-Negative Breast Cancer
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Human epidermal growth factor receptor 2 expression in early breast cancer patients : a Swiss cost-effectiveness analysis of...
No Benefit with Addition of Onartuzumab to Taxol® with or without Avastin® in Triple-Negative Breast Cancer
Cytotoxic effects of ultra-diluted remedies on breast cancer cells
Risk factor
Margolese RG, Fisher B, Hortobagyi GN, Bloomer WD (2000). "Neoplasms of the Breast". In Bast RC, Kufe DW, Pollock RE, et al. ( ... Mainly taken from risk factors for breast cancer, risk factors can be described in terms of, for example: Relative risk, such ... Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN (July 2004). "Breast carcinoma in men: a population-based study". ... of breast cancer cases are diagnosed in women." Increase in incidence in the exposed group, such as "each daily alcoholic ...
Richard Margolese
"Neoplasms of the Breast". {{cite journal}}: Cite journal requires ,journal= (help) Breast Cancer Collaborative Management. CRC ... He was a principal investigator and member of the Executive Committee of the National Surgical Adjuvant Breast Project, which, ... "Guideline 3: Mastectomy or lumpectomy? The choice of operation for clinical stages I and II breast cancer [Supplement, CMAJ - ... "Top Takeaways from ASCO: Breast Cancer". www.healio.com. Retrieved 2015-06-23. Margolese, Richard G.; Fisher, Bernard; ...
Papillary carcinomas of the breast
The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 ... Brogi E, Krystel-Whittemore M (January 2021). "Papillary neoplasms of the breast including upgrade rates and management of ... Tay TK, Tan PH (June 2021). "Papillary neoplasms of the breast-reviewing the spectrum". Modern Pathology. 34 (6): 1044-1061. ... Ross DS, D'Alfonso TM (March 2022). "Papillary Neoplasms of the Breast: Diagnostic Features and Molecular Insights". Surgical ...
Li-Fraumeni syndrome
Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". Ann. ... Erratum for "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms"". Science. 259 ( ... 1990). "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms". Science. 250 (4985): ... except breast cancer if the proband has breast cancer) before age 56 years or with multiple tumors at any age Multiple tumors ( ...
Phyllodes tumor
They account for less than 1% of all breast neoplasms. This is predominantly a tumor of adult women, with very few examples ... Breast Cancer Study Group of the Institut Curie (2011). "Management of Phyllodes Breast Tumors". The Breast Journal. 17 (2): ... Tan PH, Thike AA, Tan WJ, Thu MM, Busmanis I, Li H, Chay WY, Tan MH (2012). "Predicting clinical behaviour of breast phyllodes ... Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the local recurrence rate ...
Joseph F. Fraumeni Jr.
Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 1969:71:747-752. Li FP, Fraumeni ... Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990:250: 1233-1238. ( ...
Gardner's syndrome
The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardner's syndrome, the incidence ... The extra-abdominal form is rare and desmoids of the breast may arise in the mammary gland or may occur as an extension of a ... Rammohan A, Wood JJ (2012). "Desmoid tumour of the breast as a manifestation of Gardner's syndrome". Int J Surg Case Rep. 3 (5 ... Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck ...
Leiomyoma
Fibromyoma of the breast is an extremely rare benign breast neoplasm. Most reports in literature mention a history of ... Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, ... ISBN 0-7216-2921-0. Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, ... Accessed 2017-07-08 Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, ...
Effects of long-term benzodiazepine use
The cancers included cancer of the brain, lung, bowel, breast, and bladder, and other neoplasms. It has been hypothesised[by ...
Frederick Pei Li
... breast carcinoma, and other neoplasms in young patients. Cancer developed in an autosomal dominant pattern in 151 blood ... "Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms". Science. 250 (4985): 1233-8. ... These neoplasms also accounted for 73% of the multiple primary cancers occurring in 15 family members. Six of these patients ... These young patients had a total of 50 bone and soft tissue sarcomas of diverse histological subtypes and 28 breast cancers. ...
Rhabdomyosarcoma
"Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms". Science. 250 (4985): 1233-1238 ... Connective and soft tissue neoplasms, Small-blue-round-cell tumors, Sarcoma). ...
Breast augmentation
... neoplasm) in the fat-augmented breasts. Moreover, given the sensitive, biologic nature of breast tissue, periodic MRI and 3-D ... breast reduction, breast reconstruction, and liposuction of the breast. Nonetheless, detecting breast cancer is primary, and ... Therapy Breast augmentation via autologous fat grafts allows the oncological breast surgeon to consider conservative breast ... Post-cancer breast reconstruction After mastectomy, surgical breast reconstruction with autogenous skin flaps and with breast ...
Mouse models of breast cancer metastasis
It also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective ... 2003). Models of Breast Cancer: quo vadis, animal modeling? Breast Cancer Research 6(31), 31-38.doi: 10.1186/bcr723 Pulaski BA ... Fantozzi, A; Christofori, G (2006). "Mouse models of breast cancer metastasis". Breast Cancer Research. 8 (4): 212. doi:10.1186 ... Mice may not be an ideal model for breast cancer. This is mainly due to the lack of precision in many of the models. When ...
PubMed
", "breast cancer" to "breast neoplasms". Where appropriate, these MeSH terms are automatically "expanded", that is, include ...
Seveso disaster
In 2009, an update including 5 more years (up to 1996) found an increase in "lymphatic and hematopoietic tissue neoplasms" and ... increased breast cancer. A 2008 study evaluated whether maternal exposure is associated with modified neonatal thyroid function ...
Tetratricopeptide repeat protein 39B
TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... breast carcinoma, etc. There are five different transcript variants for the TTC39B gene. Isoform 1 is the longest transcript ...
Neurofibromin 1
... astrocytic neoplasms, phaeochromocytomas and breast cancer. No effective therapy NF1 yet exists. Instead, people with ... which develops myeloproliferative neoplasms similar to those found in NF1 juvenile myelomonocytic leukemia/JMML) were used to ... an oral selective MEK inhibitor used previously in several advanced adult neoplasms. The children enrolled in the study ...
Atypical ductal hyperplasia
Benign neoplasms, Breast neoplasia). ... The rate at which breast cancer (ductal carcinoma in situ or ... Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast ... Feb 1992). "A prospective study of benign breast disease and the risk of breast cancer". JAMA. 267 (7): 941-4. doi:10.1001/jama ... Ductal carcinoma in situ Breast cancer Collagenous spherulosis "Understanding Breast Changes - National Cancer Institute". ...
List of MeSH codes (C04)
... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ... palatal neoplasms MeSH C04.588.149.721.600 - nose neoplasms MeSH C04.588.149.721.656 - orbital neoplasms MeSH C04.588.149.721. ...
Immunocontraception
... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ... Agnantis NJ, Patra F, Khaldi L, Filis S (1992). "Immunohistochemical expression of subunit beta HCG in breast cancer". Eur. J. ...
Saliva testing
... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ... A 2000 study compared the salivary levels of a breast cancer marker (HER2/neu) in healthy women, women with benign breast ... compared saliva from breast cancer patients to that from healthy individuals and observed, notably, that breast cancer patients ... level of this marker was significantly higher in women with breast cancer than in healthy women and women with benign breast ...
List of MeSH codes (C17)
... breast cyst MeSH C17.800.090.500 - breast neoplasms MeSH C17.800.090.500.260 - breast neoplasms, male MeSH C17.800.090.500.390 ... sebaceous gland neoplasms MeSH C17.800.882.743 - sweat gland neoplasms MeSH C17.800.893.592 - leg ulcer MeSH C17.800.893.592. ... carcinoma, ductal, breast MeSH C17.800.090.500.762 - phyllodes tumor MeSH C17.800.090.750 - fibrocystic breast disease MeSH ... sweat gland neoplasms The list continues at List of MeSH codes (C18). (Wikipedia articles in need of updating from February ...
Paget's disease of the breast
Breast cancer, Epidermal nevi, neoplasms, and cysts). ... Breast changes. There may or may not be a lump in the breast, ... A breast-conserving surgery consists in the removal of the nipple, areola and the part of the breast that is affected by cancer ... Paget's disease of the breast is a type of cancer of the breast. Treatment usually involves a lumpectomy or mastectomy to ... Paget's disease of the breast can affect the nipple and areola. Symptoms typically only affect one breast. Symptoms may include ...
Health in Malaysia
... for malignant neoplasm of breast and 2.2% for transport accident. The under 5 mortality rate was 8.3 per 1000 live birth in the ... and malignant neoplasm of trachea, bronchus & lung (2.2%). In 2016, the Ischemic heart disease was the principal cause of death ... malignant neoplasm of trachea, bronchus & lung. For women, the principal cause of death was pneumonia. Deaths due to pneumonia ...
TMEM229B
B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, ...
Breast disease
A breast tumor is an abnormal mass of tissue in the breast as a result of neoplasia. A breast neoplasm may be benign, as in ... Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the ... Breast diseases make up a number of conditions. The most common symptoms are a breast mass, breast pain, and nipple discharge. ... Breast cancer is cancer of the breast tissues, most commonly arising from the milk ducts. Worldwide, breast cancer is the ...
Breast implant
"The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375-2390. doi: ... Breast Breast augmentation (Augmentation mammoplasty) Breast enlargement supplements Breast reconstruction Breast reduction ... The breast implant has no clinical bearing upon lumpectomy breast-conservation surgery for women who developed breast cancer ... The breast cancer studies Cancer in the Augmented Breast: Diagnosis and Prognosis (1993) and Breast Cancer after Augmentation ...
Invasive cribriform carcinoma of the breast
"Overview of the 2022 WHO Classification of Thyroid Neoplasms". Endocrine Pathology. 33 (1): 27-63. doi:10.1007/s12022-022-09707 ... Invasive cribriform carcinoma of the breast (ICCB), also termed invasive cribriform carcinoma, is a rare type of breast cancer ... Erber R, Hartmann A (August 2020). "Histology of Luminal Breast Cancer". Breast Care (Basel, Switzerland). 15 (4): 327-336. doi ... and outcomes of special types in breast cancer in a single institution population". The Breast Journal. 26 (11): 2163-2169. doi ...
Breast reduction
... liposuction mammoplasty also is contraindicated for any woman whose mammograms indicate the presence of unevaluated neoplasms; ... Medial Pedicle and Mastopexy Breast Reduction at eMedicine Breast Mastopexy at eMedicine Medial Pedicle and Mastopexy Breast ... from each breast, and the degree of breast ptosis present: Pseudoptosis (sagging of the inferior pole of the breast; the nipple ... when breast milk constitutes most of the breast volume. Surgically, the breast is an apocrine gland overlaying the chest - ...
Neoplasm
Breast cysts (as occur commonly during pregnancy and at other times) are another example, as are other encapsulated glandular ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
Cervical cancer
Myung SK, Ju W, Kim SC, Kim H (October 2011). "Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a ... It is the second-most common cause of female-specific cancer after breast cancer, accounting for around 8% of both total cancer ...
Fibroepithelial neoplasm
Examples include: Brenner tumor of the ovary Fibroadenoma of the breast Phyllodes tumor of the breast Tavassoli, F.A., Devilee ... A fibroepithelial neoplasm (or tumor) is a biphasic tumor. They consist of epithelial tissue, and stromal or mesenchymal tissue ... World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs. ...
Appendix cancer
Breast cancer, colon cancer, and tumors of the female genital tract may metastasize to the appendix. Carcinoid tumors are the ... Mucinous cystadenoma is an obsolete term for appendiceal mucinous neoplasm. Small carcinoids (. ...
SF3B1
October 2012). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61-70. Bibcode:2012Natur.490... ... which is a myelodysplastic syndrome/myeloproliferative neoplasm). There is also an emerging body of evidence to suggest ... myelodysplastic syndromes and breast cancer. SF3B1 mutations are found in 60%-80% of patients with refractory anemia with ring ... "Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms". Blood ...
Pseudomyxoma peritonei
For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... breast, fallopian tubes, and the pancreas. This disease is often discovered during surgery for other conditions, e.g., hernia ... Young RH (May 2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Seminars in ... ISBN 978-0-323-35909-2. Sugarbaker PH (January 2006). "New standard of care for appendiceal epithelial neoplasms and ...
Bromoketoprogesterone
It induced regression in 20% of women with advanced breast cancer at a dosage of 300 mg/day orally. Flugestone Fluorometholone ... "Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Alan C. Sartorelli; David G. Johns (eds.). ... Similarly to various other progestogens, BKP has been studied in the treatment of breast cancer in women.: 185 Evaluated in ... 9α-Bromo-11-oxoprogesterone (bromoketoprogesterone) given in a dose of 300 mg orally daily in patients with advanced breast ...
Muir-Torre syndrome
Along with neoplasms of the sebaceous gland, this patient developed cerebral neoplasms, characteristic of Turcot syndrome. ... and Breast (4%). A variety of other internal malignancies have been reported. A couple studies have been conducted on patients ... Colorectal cancer is the most common visceral neoplasm in Muir-Torre syndrome patients. It is named for EG Muir and Douglas ... Age of onset of first sebaceous neoplasm: 2 = 2 points. Personal history of Lynch related cancers: No = 0 points, Yes = 1 point ...
P16
However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients". Life Sciences. 80 (20): 1873-81. doi:10.1016/j.lfs. ... infection and neoplasms of cervical origin. The majority of SCCs of uterine cervix express p16. ...
Carney complex
Myxomas may also occur outside the heart, usually in the skin and breast. Endocrine tumors may manifest as disorders such as ... Melanocytic nevi and neoplasms, Syndromes affecting the skin, Syndromes affecting the heart, Syndromes with tumors). ... "Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ...
Prostate cancer
"Hormone Therapy for Breast Cancer , Breast Cancer Treatment". www.cancer.org. Retrieved 2022-04-28. Hammerstrom AE, Cauley DH, ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... In Europe in 2012, it was the third-most diagnosed cancer after breast and colorectal cancers at 417,000 cases. In the United ... Mutations in BRCA1 and BRCA2 (important risk factors for ovarian cancer and breast cancer in women) have also been implicated. ...
Craniopharyngioma
In premenopausal women, elevated prolactin can lead to reduction or loss of menstrual periods and/or breast milk production ( ... usually suprasellar neoplasm, which may be cystic, that develops from nests of epithelium derived from Rathke's pouch. Rathke's ...
Primary effusion lymphoma
... or breast implants (e.g. breast swelling/pain/malformation). While most cases of classical PEL involve one cavitary site, some ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ... which forms around breast implants. Less frequently, individuals present with extracavitary primary effusion lymphomas, i.e., ...
Downwinders
"Breast feeding reduces risk of breast cancer, says study," British Medical Journal, v.); Jul 27, 2002 Shaw, Palma; Duncan, ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... A related concern is that radionuclides that may be passed through the breast milk, causing some women who are downwinders to ... The increased radiosensitivity of certain organs in women, such as the breast, ovaries, and thyroid is likely the cause of this ...
Dendritic cell
Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone ... and similar abnormalities in breasts, eyes, kidneys, lungs, gastrointestinal tract, bone, sinuses, ears, and/or testes. The ... Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... Blastic plasmacytoid dendritic cell neoplasm has a high rate of recurrence following initial treatments with various ...
Virtual karyotype
Renal epithelial neoplasms have characteristic cytogenetic aberrations that can aid in classification. See also Atlas of ... and sequence alterations in breast and colorectal cancers". Proc Natl Acad Sci U S A. 105 (42): 16224-9. Bibcode:2008PNAS.. ... "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms." Nature 13 Aug 2009; 460, 904-909. Gondek LP, Tiu R, ... Malignant rhabdoid tumors are rare, highly aggressive neoplasms found most commonly in infants and young children. Due to their ...
Low-grade myofibroblastic sarcoma
Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck ... and chest wall/breast. While typically presenting as slow growing, painless masses, some individuals have presented with ... "Practical approach to diagnosis of bland-looking spindle cell lesions of the breast". Pathologica. 111 (4): 344-360. doi: ...
Cancer
Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis. Also, when ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... for breast cancer, see Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, et al. (February 2009). "Breast ... Recommends mammography for breast cancer screening every two years from ages 50-74, but does not recommend either breast self- ...
Ubiquitin
Kales SC, Ryan PE, Nau MM, Lipkowitz S (June 2010). "Cbl and human myeloid neoplasms: the Cbl oncogene comes of age". Cancer ... is an E3 ubiquitin ligase that overexpression has been shown to be the major cause of estrogen-independent breast cancer. Efp's ... "The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation". The Journal of ... "DNA copy number losses in human neoplasms". The American Journal of Pathology. 155 (3): 683-94. doi:10.1016/S0002-9440(10)65166 ...
Atypical hyperplasia
... is a high-risk premalignant lesion of the breast. It is believed that atypical ductal hyperplasia (ADH) is ... Benign neoplasms). ...
H19 (gene)
Normal breast tissue does not express H19 RNA, except during puberty and pregnancy in the mammary glands. However, in breast ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... "Breast Cell Line MCF-7". Cancer Biology - Breast Cancer Cell Line Database. University of Texas M. D. Anderson Cancer Center. ... In experiments conducted by Doyle et al., it was found that MCF-7, a breast adenomacarcinoma cell line, did not express the H19 ...
Downregulation and upregulation
FEN1 is upregulated in the majority of cancers of the breast, prostate, stomach, neuroblastomas, pancreas, and lung.[citation ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms).[verification needed] Investigation ...
Health in Australia
2nd Neoplasms (accounting for 172.8 deaths per 100,000 population) and 3rd Chronic Respiratory Disease (59.25 deaths per ... a higher incidence than conditions such as breast cancer, prostate cancer, diabetes and AIDS combined within that age range. ... 2nd Neoplasms (accounting for 201.65 deaths per 100,000 population), 3rd Neurological Disorders (accounting for 76.18 deaths ... neoplasms - 3,751 DALYs per 100,000 population mental disorders - 3,216 DALYs per 100,000 musculoskeletal disorders - 2,956 ...
Radiation therapy
For example, for breast cancer after breast-conserving surgery, radiotherapy has been found to halve the rate at which the ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... "Intraoperative radiation therapy for breast cancer patients: current perspectives". Breast Cancer: Targets and Therapy. 9: 257- ... 2005). "Breast cancer". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV (eds.). The GEC ESTRO handbook of brachytherapy. ...
List of skin conditions
Autoimmune estrogen dermatitis Autoimmune progesterone dermatitis Autosensitization dermatitis Breast eczema (nipple eczema) ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...
Gibbon ape leukemia virus
Gibbon-ape leukemia virus (GaLV) is an oncogenic, type C retrovirus that has been isolated from primate neoplasms, including ... FeLV is horizontally and vertically transmitted through biomaterials; saliva, blood, breast milk, urine and feces. Furthermore ... The virus was identified as the etiological agent of hematopoietic neoplasms, leukemias, and immune deficiencies within gibbons ...
Plasmacytoid dendritic cell
Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... and similar abnormalities in breasts, eyes, kidneys, lungs, gastrointestinal tract, bone, sinuses, ears, and/or testes. The ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of myeloid cancer in which malignant pDCs infiltrate the ... pDCs that undergo malignant transformation cause a rare hematologic disorder, blastic plasmacytoid dendritic cell neoplasm. In ...
Browsing EMRO Fact Sheets by Subject "Breast Neoplasms"
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V ... Policy statement and recommended actions for early detection of breast cancer in the Eastern Mediterranean Region ... Policy statement and recommended actions for early detection of breast, cervical, colorectal, oral and prostate cancers in the ...
Browsing by Subject "Breast Neoplasms"
Breast cancer is the most common malignant neoplasm affecting women in Bahrain. We studied the demographic characteristics and ... Breast self-examination practice and its impact on breast cancer diagnosis in Alexandria, Egypt ... Breast cancer prognosis in Salah Azaiez Institute of Cancer, Tunis] Ben Gobrane, H.; Fakhfakh, R.; Rahal, K.; Ben Ayed, F.; ... Breast cancer is the commonest type of malignancy in Iraq. The study was carried out on 721 out of a total of 5044 patients [ ...
breast benign neoplasm Disease Ontology Browser - DOID:0060082
Digitally Distributed Yoga for Women Treated for Breast Cancer | Clinical Research Trial Listing ( Breast Neoplasm Female ) (...
Digitally Distributed Yoga for Women Treated for Breast Cancer ... Yes for Clinical diagnosed with breast cancer Adult women Must ... Not sure for Clinical diagnosed with breast cancer Adult women Must have undergone breast cancer surgery inclusion criteria 1 ... No for Clinical diagnosed with breast cancer Adult women Must have undergone breast cancer surgery inclusion criteria 1 ... Clinical diagnosed with breast cancer Adult women Must have undergone breast cancer surgery. ...
2023 ICD-10-CM Diagnosis Code D48.6: Neoplasm of uncertain behavior of breast
ICD 10 code for Neoplasm of uncertain behavior of breast. Get free rules, notes, crosswalks, synonyms, history for ICD-10 code ... neoplasm of uncertain behavior of cartilage of nose (D38.5). *neoplasm of uncertain behavior of connective tissue of breast ( ... Neoplasm of uncertain behavior of breast. 2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code *D48.6 should ... For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, ...
Inflammatory breast neoplasms: a systematic review
FERREIRA, Naidhia Alves Soares et al. Inflammatory breast neoplasms: a systematic review. Rev. bras. crescimento desenvolv. hum ... "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). FINDINGS: Of the ... OVERVIEW: Inflammatory Breast Cancer (IBC) is a rare and very aggressive type of cancer that tends to develop at a younger age ... compared with other subtypes of breast cancer. Because a distinct lump may not be noticeable, correct diagnosis takes longer ...
Benign and malignant breast neoplasms | Patient Innovation
Results of search for 'su:{Breast neoplasms.}' › WHO HQ Library catalog
Oral contraceptives & breast cancer / Committee on the Relationship between Oral Contraceptives and Breast Cancer, Institute of ... Smoking and breast cancer / Jonas Manjer. by Manjer, Jonas.. Material type: Text; Format: print Publication details: Malmö : ... Breast cancer screening / [editor] Ismail Jatoi. by Jatoi, Ismail.. Material type: Text; Format: print Publication details: ... Prevention of breast cancer / Ian S. Fentiman. by Fentiman, Ian S.. Series: Medical intelligence unitMaterial type: Text; ...
Clinical Trial for Breast Neoplasms. | Pfizer
View information on a Breast Neoplasms clinical trial: Pfizer study NCT05478590. See if you may be eligible. ... Breast Neoplasms. Who may participate. Each clinical study has its own guidelines for who may participate, called eligibility ... Breast Neoplasms. The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions ... A Study to Describe Treatment Patterns of Advanced Breast Cancer in Poland in the Real-world Data Setting. NCT# stands for ...
Malignant neoplasm, male breast
Impact of the IGFBP3 A-202C polymorphism on susceptibility and clinicopathologic features of breast cancer
Our results suggest that the functional IGFBP3 A-202C polymorphism may influence the susceptibility and progression of breast ... Breast Neoplasms / genetics* * Breast Neoplasms / pathology* * Case-Control Studies * Female * Gene Frequency / genetics ... Impact of the IGFBP3 A-202C polymorphism on susceptibility and clinicopathologic features of breast cancer Biomed Pharmacother ... Methods: We genotyped the IGFBP3 A-202C polymorphism in a case-control study involving 465 breast cancer patients and 799 age- ...
Male Breast Cancer: MedlinePlus
Although breast cancer is much more common in women, men can get it too. Learn more. ... Did you know that men can get breast cancer? ... ClinicalTrials.gov: Breast Neoplasms, Male (National Institutes ... Breast lumps usually arent cancer. However, most men with breast cancer have lumps. Other breast symptoms can include:. * ... Breast Biopsy (National Library of Medicine) Also in Spanish * Can Breast Cancer in Men Be Found Early? (American Cancer ...
Metastases in the Breast from Nonmammary Malignant Neoplasms | Basicmedical Key
Hoda The preoperative clinical workup of an apparently healthy patient with a breast mass can be cursory and is unlikely to ... Metastases in the Breast from Nonmammary Malignant Neoplasms Syed A. ... Hematopoietic and lymphoid neoplasms involving the breast are sometimes listed under the rubric of breast "metastases," but ... If hematopoietic and lymphoid neoplasms are excluded, the most common NMMNs that secondarily involve the breast include ...
Biblio | Page 5 | Linus Pauling Institute | Oregon State University
Breast Neoplasms. Atwell LL, Zhang Z, Mori M, Farris P, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J. 2015. ... Prostatic Neoplasms. Preble I, Zhang Z, Kopp R, Garzotto M, Bobe G, Shannon J, Takata Y. 2019. Dairy Product Consumption and ... Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy.. Cancer Prev Res (Phila). 8(12 ... Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy.. Cancer Prev Res (Phila). 8(12 ...
CIENCIASMEDICASNEWS: National Guideline Clearinghouse | Guidelines by Topic: Breast Neoplasms [1/4]
Breast Neoplasms, Male (7). Carcinoma, Ductal, Breast (2). Hereditary Breast and Ovarian Cancer Syndrome (1) ... Breast Neoplasms. Guidelines by Topic. Disease/Condition , Diseases (2488) , Neoplasms (653) , Neoplasms by Site (502) , ... Familial breast cancer: classification and care of people at risk of familial breast cancer and management of breast cancer and ... consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast ...
RXQ RX J
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial |...
... health guidelines resulted in reduced adiposity levels in previously sedentary postmenopausal women at higher risk of breast ... exercise intervention on adiposity outcomes that may be involved in the association between physical activity and breast cancer ... Table 1 Characteristics of participants at baseline in the Alberta Physical Activity and Breast Cancer Prevention Trial, n=320 ... Ballard-Barbash R, Swanson CA . Body weight: estimation of risk for breast and endometrial cancers. Am J Clin Nutr 1996; 63: ...
Developing a risk prediction model for breast cancer: a Statistical Utility to Determine Affinity of Neoplasm (SUDAN-CA Breast)...
SUDAN predictors of breast cancer were: age, menarche, family history, vegetables and fruits weekly servings, and type of ... we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women. Using cross-sectional ... efficient and well-calibrated tool to predict and classify womens lifetime risks of developing breast cancer. Input from our ... Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed ...
Stereotactic body radiotherapy for oligometastatic lung tumors
dbGaP Study
The Australian Breast Cancer Family Study (ABCFS), the British Breast Cancer Study (BBCS), the Breast and Prostate Cancer ... Primary Phenotype: Breast Neoplasms Links to Related Resources * BioProject * PubMed * MeSH * PMC ... the Singapore and Sweden Breast Cancer Study (SASBAC), the Triple Negative Breast Cancer Study (TNBC), and the UK2 GWAS. These ... German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC), the Helsinki breast cancer family Study (HEBCS), the ...
C50.829 - Malignant neoplasm of overlapping sites of unspecified male breast - ICD List 2023
Synonyms: malignant neoplasm of overlapping sites of breast, malign ... Billable ICD-10 code to specify malignant neoplasm of overlapping sites of unsp male breast. ... Malignant neoplasm of central portion of breast. NON-BILLABLE CODE. C50.11. Malignant neoplasm of central portion of breast, ... Malignant neoplasm of overlapping sites of breast. *Neoplasm of breast primary tumor staging category T4: Direct extension to ...
ICD-10 code C50.421 | Malignant neoplasm of upper-outer quadrant of right male breast
ICD-10 code C50.421 for Malignant neoplasm of upper-outer quadrant of right male breast online definition ... ICD-10 code C50.421 for Malignant neoplasm of upper-outer quadrant of right male breast ... Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except ...
Browsing 2. Regional Office for Africa by Subject
Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast...
Breast Neoplasms. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Fulvestrant. Antineoplastic Agents, Hormonal. ... advanced breast cancer. alpelisib. fulvestrant. PI3K. Phase III. ER+. PgR+. men. postmenopausal. aromatase inhibitor. neoplasms ... newly diagnosed advanced breast cancer, then relapsed with documented evidence of progression while on or after only one line ... Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast ...
Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based...
Breast Neoplasms. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Talazoparib. Poly(ADP-ribose) Polymerase ... Metastatic breast cancer with deleterious somatic BRCA 1 or 2 mutations detectable by cell-free circulating tumor DNA, by CLIA ... Triple negative breast cancer (defined as ER , 1%, PR , 1%, HER2 negative, as per ASCO CAP guidelines), with disease ... At least two weeks from last systemic therapy for breast cancer, with recovery of all treatment related toxicity to grade 1 or ...
"The Effect of Timing of Radiotherapy after Breast-conserving Surgery in Patients with Positive or Close Resection Margins,...
N0 breast cancer were treated with breast-conserving surgery and breast irradiation, between January 1, 1985, and December 31, ... For patients with positive resection margins, the time intervals from breast surgery to breast irradiation used for analysis ... Patients with positive resection margins have higher local recurrence rates that become apparent when breast irradiation is ... The aim of this study was to determine the effect of timing of radiotherapy after conservative breast surgery on local ...
Histopathological patterns of breast neoplasms: A study in tertiary care hospital | International Journal of Clinical and...
The main aim of this study is to find out the various histopathological patterns and distribution of neoplastic breast lesions ... Histopathological patterns of breast neoplasms: A study in tertiary care hospital. Int J Clin Diagn Pathol 2020;3(2):24-29. DOI ... Histopathological patterns of breast neoplasms: A study in tertiary care hospital. Dr. Hima Bindu Gurram, Dr. Yarlagadda ... The main aim of this study is to find out the various histopathological patterns and distribution of neoplastic breast lesions ...
Li-Fraumeni Syndrome Clinical Presentation: History, Physical, Causes
Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?. Ann Intern Med. 1969 Oct. 71(4):747-52. [QxMD ... Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990 Nov 30. 250(4985 ... Breast self-examination training and regular monthly breast self-examination, starting at age 18 years. [31] ... Excess risk of breast cancer in the mothers of children with soft tissue sarcomas. Br J Cancer. 1984 Mar. 49(3):325-31. [QxMD ...
CarcinomaTumorMalignant Neoplasm of BreastDuctalMetastasisBiomarkersRecurrenceEpidemiologyLungBenignRadiotherapyMastectomyPathologyLymphoid neoplasmsCancersMortalityLobularDiseasesCancer SurvivorsTumorsPancreasClinicalInvasive breast cancerGeneticMeSH TermsAdjuvantLymphomaApoptosisIncidencePreventionClassificationMetastatic breast cancerProgressionSurvivalNeoplasticSymptomsRadiationMutationPrognosis
Carcinoma10
- Carcinoma of the breast is the most prevalent cancer among Egyptian women and constitutes 29% of National Cancer Institute cases. (who.int)
- Breast carcinoma : risk and detection / Cushman D. Haagensen, Carol Bodian, Darrow E. Haagensen. (who.int)
- Metastasis from the contralateral breast is a diagnostic consideration when there is bilateral involvement (or history thereof), the histologic appearances of the tumors in the breasts are similar, and there is no evidence of in situ carcinoma in the contralateral breast. (basicmedicalkey.com)
- Radiologic techniques such as MRI (magnetic resonance imaging) and FDG-PET/CT (fluorodeoxyglucose-positron emission tomography-computed tomography) have also detected metastases in the breast from carcinoma of the thyroid ( 7 ), ovary ( 8 ), and soft tissue liposarcoma ( 9 ). (basicmedicalkey.com)
- Melanoma arising in the breast is usually a form of metaplastic carcinoma, and it may therefore express cytokeratin. (basicmedicalkey.com)
- The protocol includes frequent laboratory and radiographic screening for adrenocortical carcinoma, brain tumors, soft-tissue and bone sarcoma, leukemia/lymphoma, breast cancer, and colon cancer. (medscape.com)
- Els H, Breast carcinoma. (radiopaedia.org)
- Positive family history of breast carcinoma. (radiopaedia.org)
- 516 biopsy confirmed, newly diagnosed patients with primary carcinoma of the breast constituted the cases, while the controls were 516 women matched for age (+ 5 years to that of the case) without breast cancer living in close vicinity. (who.int)
- In breast invasive carcinoma (BRCA) and liver hepatocellular carcinoma (LIHC), high YIF1B expression correlated with a poor disease-free interval (DFI), indicating a role in malignancy progression. (silverchair.com)
Tumor10
- A type of tumor found in breast or prostate tissue. (icd10data.com)
- Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. (icdlist.com)
- In this research study, the investigators are examining how effective talazoparib is in patients with metastatic breast cancer with a BRCA mutation in their tumor. (clinicaltrials.gov)
- At that time, a needle biopsy of the breast tumor or a sentinel (underarm) lymph node biopsy will also be performed. (knowcancer.com)
- The aims of the project are 1) to identify and understand novel mechanisms regulating breast cancer cell death and 2) to identify molecular patterns of importance for the tumor biology and disease outcome. (lu.se)
- Patients with advanced, histologically confirmed pancreatic, breast, non-small-cell lung cancer (NSCLC), gastric, esophageal, head and neck, or ovarian tumors that recurred after or has been refractory to prior therapy (fresh tumor biopsy or an archived sample testing for Nectin-4 expression). (bcan.org)
- The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been determined in breast cancers. (e-crt.org)
- High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. (e-crt.org)
- The purpose of this study is to determine if a combination of two drugs ipatasertib and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. (survivornet.com)
- Definitive breast surgery must have been performed and includes lumpectomy or mastectomy with pathologically clear margins (i.e. no ink on tumor). (survivornet.com)
Malignant Neoplasm of Breast1
- The example below shows malignant neoplasm of breast detailed with laterality and specific anatomy. (who.int)
Ductal1
- In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). (icdlist.com)
Metastasis3
- The preoperative clinical workup of an apparently healthy patient with a breast mass can be cursory and is unlikely to exclude a metastasis from a clinically inapparent (that is, "occult") nonmammary malignant neoplasm (NMMN). (basicmedicalkey.com)
- Thus, when faced with a mammary neoplasm that has unusual clinical, radiologic, or histologic features, it is important to consider metastasis in the differential diagnosis. (basicmedicalkey.com)
- In approximately one-third of the cases, the metastasis in the breast is the first presentation of the NMMN. (basicmedicalkey.com)
Biomarkers2
Recurrence4
- ACR Appropriateness Criteria® stage I breast cancer: initial workup and surveillance for local recurrence and distant metastases in asymptomatic women. (blogspot.com)
- Purpose: The aim of this study was to determine the effect of timing of radiotherapy after conservative breast surgery on local recurrence in women with positive resection margins and young age, treated without systemic therapy. (bepress.com)
- Patients with positive resection margins have higher local recurrence rates that become apparent when breast irradiation is delayed. (bepress.com)
- Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy will be beneficial. (elsevier.com)
Epidemiology4
- Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
- Breast cancer : epidemiology, endocrinology, biochemistry and pathobiology / Helmuth Vorherr. (who.int)
- Breast and gynecologic cancer epidemiology / authors, Jennifer L. Kelsey, Nancy G. Hildreth. (who.int)
- DE SILVA, AASO, Some aspects in the epidemiology of breast cancer in women Sri Lanka, Post Graduate Institute of Medicine, Colombo PGIM , 1992: p. (who.int)
Lung7
- If hematopoietic and lymphoid neoplasms are excluded, the most common NMMNs that secondarily involve the breast include carcinomas of the lung, ovary, stomach, kidney, and cutaneous melanoma. (basicmedicalkey.com)
- Among the metastatic carcinomas in the breast that are most likely to be mistaken for a breast primary are those arising in the lung, ovary, mullerian system, and bowel. (basicmedicalkey.com)
- The primary involved organs were the lung (n = 15), colorectum (n = 9), head and neck (n = 5), kidney (n = 3), breast (n = 1), and bone (n = 1). (nih.gov)
- Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). (nih.gov)
- Patients with breast cancer, colorectal cancer, or lung cancer were recruited to complete the EQ-5D-3L and EQ-5D-5L questionnaires. (bsl.nl)
- A total of 1802 cancer patients (breast cancer: 601, colorectal cancer: 601, lung cancer: 600) were included, with the mean age of 55.6 years. (bsl.nl)
- With these static MLC fields creating the intensity modulation, the dose uniformity to the breast can be significantly improved and the hot region in lung reduced. (iaea.org)
Benign5
- A thoracic benign neoplasm that is characterized by lack of malignancy. (jax.org)
- Categories D37 - D44 , and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. (icd10data.com)
- A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. (icd10data.com)
- Most breast masses in adolescents are benign and self-limited. (pediatriconcall.com)
- K) Women who had a positive history of benign breast disease were at an increased risk of breast cancer relative to women who did not have such a history. (who.int)
Radiotherapy1
- The Effect of Timing of Radiotherapy after Breast-conserving Surgery in Patients with Positive or Close Resection Margins, Young Age, and Node-negative Disease, with Long Term Follow-up" International Journal of Radiation Oncology, Biology, Physics Vol. 66 Iss. (bepress.com)
Mastectomy4
- The stratified randomization will be according to surgery, Breast-Conserving Surgery (BCS) versus mastectomy (ME), chemotherapy versus no chemotherapy. (centerwatch.com)
- Primary management of breast cancer : alternatives to mastectomy / edited by Jeffrey S. Tobias and Michael J. Peckham. (who.int)
- Treatment for male breast cancer is usually a mastectomy, which is surgery to remove the breast. (icdlist.com)
- After completing 4 cycles (12 weeks) of capecitabine, patients will then undergo surgery to remove any remaining breast cancer (lumpectomy or mastectomy). (knowcancer.com)
Pathology1
- It is essential to have a deep knowledge in pediatric breast pathology to provide the most adequate treatment to each patient. (pediatriconcall.com)
Lymphoid neoplasms1
- Hematopoietic and lymphoid neoplasms involving the breast are sometimes listed under the rubric of breast "metastases," but they are best regarded as either primary breast neoplasms or as a manifestation of a systemic condition, depending upon the extent of organ involvement. (basicmedicalkey.com)
Cancers10
- Reproductive factors and risk of cancers of the breast and genital organs : a prospective study of Norwegian women / by Gunnar Kvale. (who.int)
- PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER gene (ESR1LBDm). (cam.ac.uk)
- We utilize public data as and molecular data generated within the SCANB project, a continuous collection of consecutive material of breast cancers operated in Southern Sweden. (lu.se)
- Skin cancer, male genital system cancers, and in situ neoplasms (e.g., skin and breast) are the most common WTC-related certified cancer conditions. (cdc.gov)
- Today, we recognize that ER-positive breast cancers and ER-negative breast cancers constitute different diseases [1]. (2medicalcare.com)
- Here,we evaluated TILs and MxA expression in human epidermal growth factor receptor 2 (HER2)-positive breast cancers. (e-crt.org)
- High levels of TILs were also associated with improved disease-free survival, particularly in HR-/HER2+ breast cancers. (e-crt.org)
- The prognostic significance of TILs has been determined in breast cancers, particularly human epidermal growth factor receptor 2 (HER2)-positive breast cancers and triple-negative breast cancers [ 1 ]. (e-crt.org)
- Based on this background, a group of investigators around the world convened to discuss the parameters and methodological issues associated with evaluating TILs in breast cancers [ 4 ] and released recommendations for their evaluation. (e-crt.org)
- The U.S. Food and Drug Administration (FDA) has not approved atezolizumab (Tecentriq) for residual triple negative breast cancer but it has been approved for advanced triple negative breast cancer and other cancers. (survivornet.com)
Mortality3
- Determine all-cause mortality compared to the general male population and analyze survival/mortality compared with Danish female breast cancer patients (FBCP) in the same period. (aau.dk)
- which was evidenced in a national survey, Breast cancer is one of the most which analyzed the growth of the mortality incidents in the world and the most frequent rate from the disease in Brazil, in which an among women. (bvsalud.org)
- It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. (unc.edu)
Lobular1
- 3.0 × 10(-3) were selected for replication using pooled case-control data from 11 studies of the Breast Cancer Association Consortium, including 7689 cases (676 lobular) and 9266 controls. (qub.ac.uk)
Diseases1
- Risk factors for male breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or Klinefelter syndrome. (icdlist.com)
Cancer Survivors9
- For instance, a population-based nested case-control study involving breast cancer survivors showed that obesity, alcohol intake and smoking increased the risk of a second breast cancer appreciably. (cmaj.ca)
- 2015. Depression and vasomotor symptoms in young breast cancer survivors: the mediating role of sleep disturbance. . (ucla.edu)
- 2015. Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. . (ucla.edu)
- 2015. Motivations associated with physical activity in young breast cancer survivors. . (ucla.edu)
- 2015. Psychological Adjustment in Breast Cancer Survivors. . (ucla.edu)
- 2014. Childhood adversity and inflammation in breast cancer survivors. . (ucla.edu)
- 2014. Low heart rate variability and cancer-related fatigue in breast cancer survivors. . (ucla.edu)
- 2014. Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial. . (ucla.edu)
- 2014. Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial. . (ucla.edu)
Tumors5
- For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
- As a result, metastatic tumors cannot be distinguished radiologically from circumscribed primary breast carcinomas, particularly those of the papillary, medullary, or mucinous types. (basicmedicalkey.com)
- Some types of breast tumors such as small cell, adenoid cystic, and mucoepidermoid carcinomas can occur in other organs, and appropriate clinical workup is prudent in these cases. (basicmedicalkey.com)
- Guerreiro F P, Martins M, Rasteiro D, Pires P R, Ladeira C. Tumors of the Adolescent Breast - Regarding a Clinical Case. (pediatriconcall.com)
- Tumors or cancer of the human BREAST . (bvsalud.org)
Pancreas1
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
Clinical15
- Clinical Trial for Breast Neoplasms. (pfizerclinicaltrials.com)
- The main goals are to assess the current treatment patterns of hormone receptor-positive (HR+) Human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer and their changes in clinical practice and relate them to patients' demographics, disease characteristics, type of other therapies used in patients as well as disease progression and visceral crisis occurrence. (pfizerclinicaltrials.com)
- A physical exam, including a clinical breast exam (CBE). (medlineplus.gov)
- Metastases from NMMN are rare and account for less than 1% of all mammary malignant neoplasms in clinical series, and up to 5% of autopsies of patients who die as a result of NMMN ( 1 ). (basicmedicalkey.com)
- Use of pharmacologic interventions for breast cancer risk reduction: American Society of Clinical Oncology clinical practice guideline. (blogspot.com)
- Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. (blogspot.com)
- Evidence-based clinical practice guideline: breast reconstruction with expanders and implants. (blogspot.com)
- Breast cancer risk prediction models are widely used in clinical settings. (biomedcentral.com)
- Clinical evaluation can be particularly challenging due to normal breast tissue development and natural changes. (pediatriconcall.com)
- See CLINICAL STUDIES and WARNINGS, Cardiovascular Disorders and Malignant Neoplasms, Breast Cancer. (nih.gov)
- These findings enhance the value of the IHC4-score as an adjunct to clinical prognostication tools for aiding chemotherapy decision-making in luminal breast cancer patients, irrespective of subtype. (elsevier.com)
- Anatomopathological evaluation of the surgical specimens of mammoplasties may be important for the detection of breast tissue changes without previous clinical manifestations, but in our series there were no cases of malignancies, and this conduct should be discussed. (rbcp.org.br)
- The M group shows the worst outcomes and the IM genetic analysis of breast cancer is not easily available in clinical group shows the best outcomes [8]. (2medicalcare.com)
- as a treatment for B-cell neoplasms have shown some promising results in clinical trials, their clinical use is limited, partially due to the risk of cytokine-release syndrome (CRS) occurring in response to the treatment. (ajmc.com)
- It has been applied to the clinical service by utilizing DHPLC for the genetic diagnosis of BRCA1 and BRCA2 of breast cancer patients in the department of Genetic Medicine of our hospital. (knowcancer.com)
Invasive breast cancer3
- Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. (blogspot.com)
- The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (nih.gov)
- Pathologically confirmed residual invasive breast cancer, in the breast and/or lymph node(s), following neoadjuvant chemotherapy. (survivornet.com)
Genetic8
- Breast cancer happens when there are changes in the genetic material (DNA). (medlineplus.gov)
- Breast cancer that is caused by inherited genetic changes is called hereditary breast cancer. (medlineplus.gov)
- There are also certain genetic changes that can raise your risk of breast cancer, including changes in the BRCA1 and BRCA2 genes. (medlineplus.gov)
- Logistic regression was used to assess the genetic association between the occurrence and progression of breast cancer. (nih.gov)
- NSGC practice guideline: risk assessment and genetic counseling for hereditary breast and ovarian cancer. (blogspot.com)
- Given the genetic variations in risk factors that exist between different races, we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women. (biomedcentral.com)
- Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) was one of five projects funded in 2010 as part of the NCI's Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative ( http://epi.grants.cancer.gov/gameon/ ). (nih.gov)
- Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study. (cdc.gov)
MeSH Terms1
- This is a systematic review of studies in the PubMed database to April 2013, which fit the eligibility criterion of "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). (bvsalud.org)
Adjuvant4
- To determine whether treatment with alpelisib plus fulvestrant prolongs progression-free survival compared to fulvestrant and placebo in men and postmenopausal women with hormone receptor positive (HR+), HER2- negative advanced breast cancer, who received prior treatment with an Aromatase Inhibitor either as (neo)adjuvant or for advanced disease. (clinicaltrials.gov)
- 2014. Cognitive function after the initiation of adjuvant endocrine therapy in early-stage breast cancer: an observational cohort study. . (ucla.edu)
- 2013. The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer. . (ucla.edu)
- In the adjuvant setting, a high level of TILs is associated with better response to trastuzumab, and an abundant number of TILs is an independent prognostic factor in HER2-positive breast cancer [ 3 ]. (e-crt.org)
Lymphoma2
- In the pediatric population, lymphoma and rhabdomyosarcoma are the most common sources of NMMN in the breast. (basicmedicalkey.com)
- Increased susceptibility to infection and the possible development of lymphoma and other neoplasms may result from the increase in the degree of immunosuppression in transplant patients. (rxlist.com)
Apoptosis2
Incidence1
- This article presents the incidence of female breast cancer in the Gulf Cooperation Council [GCC] countries and reviews the data in relation to established reproductive factors. (who.int)
Prevention4
- Prevention of breast cancer / Ian S. Fentiman. (who.int)
- Oral contraceptives & breast cancer / Committee on the Relationship between Oral Contraceptives and Breast Cancer, Institute of Medicine, Division of Health Promotion and Disease Prevention. (who.int)
- The Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial was designed to increase the understanding of the biological mechanisms that mediate the inverse association between physical activity and breast cancer risk. (nature.com)
- from the analysis emerged the theme, development of women's autonomy for the prevention of breast cancer. (bvsalud.org)
Classification2
- Familial breast cancer: classification and care of people at risk of familial breast cancer and management of breast cancer and related risks in people with a family history of breast cancer. (blogspot.com)
- For example, additional 'Histopathology' information could be added to most of the Neoplasm categories but it cannot be added to the categories elsewhere in the classification. (who.int)
Metastatic breast cancer4
- Eighty-eight women presenting with locally advanced or metastatic breast cancer were treated with tamoxifen alone. (who.int)
- This research is to evaluate the effectiveness of Talazoparib as a potential treatment for metastatic breast cancer with a BRCA 1 or BRCA 2 mutation. (clinicaltrials.gov)
- The U.S. Food and Drug Administration (FDA) has not approved talazoparib for the participants' specific disease but it has been approved for metastatic breast cancer with a germline (inherited) BRCA mutation. (clinicaltrials.gov)
- 2015. Living with Metastatic Breast Cancer. . (ucla.edu)
Progression2
- The present study determined the impact of an important promoter polymorphism (A-202C, rs2854744) on susceptibility and progression of breast cancer in a Chinese population. (nih.gov)
- Our results suggest that the functional IGFBP3 A-202C polymorphism may influence the susceptibility and progression of breast cancer in the Chinese population. (nih.gov)
Survival2
- We estimated survival rate at 9 years of all [470] women with breast cancer diagnosed at Salah Aza‹ez Institute of Cancer in Tunis to identify the main prognosis factors. (who.int)
- Hazard ratios and 95% confidence intervals for associations with 10-year breast cancer-specific survival were estimated in Cox proportional-hazard models. (elsevier.com)
Neoplastic1
- The main aim of this study is to find out the various histopathological patterns and distribution of neoplastic breast lesions in various age groups in our institute. (patholjournal.com)
Symptoms6
- What are the signs and symptoms of breast cancer? (medlineplus.gov)
- In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. (icdlist.com)
- 2015. Depressive episodes, symptoms, and trajectories in women recently diagnosed with breast cancer. . (ucla.edu)
- 2015. Symptoms and Symptom Attribution Among Women on Endocrine Therapy for Breast Cancer. . (ucla.edu)
- 2014. Cancer-related intrusive thoughts predict behavioral symptoms following breast cancer treatment. . (ucla.edu)
- The treatment includes correction of breast asymmetries by using silicone breast implants in patients without cardiopulmonary symptoms, only with esthetic complaints. (rbcp.org.br)
Radiation1
- This is a multicenter, observational, retrospective, cross-sectional study conducted in breast clinics of Bashaier University Hospital (BUH) and Khartoum Center for Radiation and Isotopes (RICK), Khartoum, Sudan. (biomedcentral.com)
Mutation2
- US Preventive Services Task Force guidelines recommend BRCA1/2 mutation testing for women at a high risk of CA breast [ 7 ]. (biomedcentral.com)
- Women with BRCA1 gene mutation have 80% to get breast cancer before the age of 70 and 63% of them would get ovarian cancer before the age of 70. (knowcancer.com)
Prognosis2
- Aberrant FN expression was associated with poor prognosis in patients with luminal type A breast cancer. (elsevier.com)
- The prognosis of HER2-positive breast cancer has dramatically improved because of introduction of trastuzumab, a humanized monoclonal antibody targeting the extracellular domain of HER2. (e-crt.org)